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Dipyrone in fever children

Maria J B Cruz, Lays F N Dourado, Emerson C Bodevan, Renata A Andrade, Delba F Santos
OBJECTIVE: Determine the prevalence of medication use in children and adolescents in 20 municipalities of Vale do Jequitinhonha, Minas Gerais-Brazil, showing the main groups and variables that may have influenced use. METHODS: Descriptive population-based survey sample of 555 interviews, selected by simple random cluster sampling of 137 census tracts. Inclusion criteria were age ≤ 14 years, mandatory interview with the legal guardians, and regardless of having received medications...
November 2014: Jornal de Pediatria
Gracian Li Pereira, Noemia U L Tavares, Sotero S Mengue, Tatiane da S Dal Pizzol
OBJECTIVE: The evidence on the effectiveness of alternating antipyretics in fever management is scarce and indicates clinically negligible differences. The present study aimed to describe therapeutic procedures and the use of alternating antipyretics in children, and to evaluate associated factors. METHODS: This was a cross-sectional study with 692 children aged 0 to 6 years, living in Southern Brazil. Household interviews of the children's caregivers were conducted through cluster sampling using a structured questionnaire...
January 2013: Jornal de Pediatria
Gracian Li Pereira, Noemia U L Tavares, Sotero S Mengue, Tatiane S Dal Pizzol
OBJECTIVES: To describe therapeutic conducts and the alternate use of antipyretics in children, and to evaluate factors associated with this use. METHODS: Cross-sectional study with 692 children from 0 to 6 years, living in southern Brazil. Through cluster sampling, we carried out household interviews with caregivers, using a structured questionnaire. A descriptive analysis was performed and the association between sociodemographic factors and the alternate use of antipyretics was evaluated. We analyzed 630 cases (91...
December 28, 2012: Jornal de Pediatria
Zeina Bárzaga Arencibia, Imti Choonara
Paracetamol (acetaminophen) and ibuprofen are the most frequently purchased over-the-counter (OTC) medicines for children. Parents purchase these medicines for the treatment of fever and pain. In some countries other NSAIDs such as aspirin (acetylsalicylic acid) and dipyrone are available. We aimed to perform a narrative review of the efficacy and toxicity of OTC analgesic medicines for children in order to give guidance to health professionals and parents regarding the treatment of pain in a child. Neither aspirin nor dipyrone are recommended for OTC use because of the association with Reye's syndrome for the former and the risk of agranulocytosis for the latter...
December 1, 2012: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Gracian Li Pereira, Josiane Magda Camarotto Dagostini, Tatiane da Silva Dal Pizzol
OBJECTIVE: To summarize the existing evidence on the efficacy of therapy with alternating antipyretics compared to monotherapy in the management of fever in children. SOURCES: MEDLINE, EMBASE, Cochrane Library, LILACS, SciELO, IBECS, Web of Science, Clinical Trials, Google Scholar and references of the articles found. The review included randomized clinical trials published until December 2011, in which one of the arms was the alternating antipyretics therapy to treat fever in children younger than 12 years, treated on an outpatient basis...
July 2012: Jornal de Pediatria
Ana Maria Magni, Daniel Kashiwamura Scheffer, Paula Bruniera
OBJECTIVE: To evaluate temperature changes in febrile children that received a single oral dose of ibuprofen (10 mg/kg), the dose recommended for high fever, or dipyrone (15 mg/kg), the dose recommended by the manufacturer, at 2, 3, 4, 5, 6, 7 and 8 hours after administration. METHODS: This open-label randomized (1:1) controlled clinical tried enrolled 80 febrile boys and girls aged 6 months to 8 years with baseline axillary temperatures of 38.0 to 40.3 °C. The children were divided into two groups: high fever (> 39...
January 2011: Jornal de Pediatria
João Guilherme Bezerra Alves, Natália Dornelas Câmara Marques de Almeida, Camila Dornelas Câmara Marques de Almeida
CONTEXT AND OBJECTIVE: The role of tepid sponging to promote fever control in children is controversial. We did not find any studies reporting on the effectiveness of tepid sponging in addition to dipyrone. The aim of this study was to compare the effects of tepid sponging plus dipyrone with dipyrone alone for reducing fever. DESIGN AND SETTING: A randomized clinical trial was undertaken at Instituto Materno-Infantil Professor Fernando Figueira, Recife, Pernambuco...
March 6, 2008: São Paulo Medical Journal, Revista Paulista de Medicina
Hayri L Yilmaz, Nazan Alparslan, Dincer Yildizdas, Ibrahim Bayram, Emre Alhan
OBJECTIVE: To compare the effectiveness and rate of temperature reduction of three antipyretic medications in febrile children. DESIGN: A single-dose, randomised, prospective, modified double-blind, parallel clinical trial. SETTING: The paediatric emergency department of a university hospital that has 13 000 annual visits. STUDY PARTICIPANTS: 252 otherwise healthy children aged 6 months to 14 years with acute, intercurrent, febrile illness...
2003: Clinical Drug Investigation
João Guilherme Bezerra Alves, Fortunato José Cardoso Neto, Camila Dornelas Câmara Almeida, Natalia Dornelas Câmara Almeida
CONTEXT AND OBJECTIVE: Several studies in developed countries have documented that a significant percentage of children are given inappropriate doses of acetaminophen and ibuprofen. The objective of this paper was to investigate parents' accuracy in giving dipyrone and acetaminophen to their children, in a poor region. DESIGN AND SETTING: Cross-sectional study at the pediatric emergency department of Instituto Materno-Infantil Prof. Fernando Figueira, a teaching hospital in Pernambuco...
January 4, 2007: São Paulo Medical Journal, Revista Paulista de Medicina
Judith Prado, Raúl Daza, Oscar Chumbes, Iván Loayza, Luis Huicho
CONTEXT AND OBJECTIVE: Dipyrone is a widely used over-the-counter antipyretic in Latin America, and elsewhere among Latin immigrants. Despite limited evidence, physicians often prescribe oral ibuprofen or intramuscular dipyrone as the most effective antipyretics. Our aim was to compare the antipyretic efficacy and tolerability of a single dose of oral ibuprofen, oral dipyrone or intramuscular dipyrone in febrile children. DESIGN AND SETTING: Randomized, single-blind clinical trial, at San Bartolomé Mother-Child National Teaching Hospital, Lima, Peru...
May 4, 2006: São Paulo Medical Journal, Revista Paulista de Medicina
A Wong, A Sibbald, F Ferrero, M Plager, M E Santolaya, A M Escobar, S Campos, S Barragán, M De León González, G L Kesselring
This study compared the antipyretic effectiveness of acetaminophen, ibuprofen, and dipyrone in young children with fever. The results were based on a modified double-blind, randomized, multinational trial that evaluated 628 febrile children, aged 6 months to 6 years. All three drugs lowered temperature in the 555 patients completing the study. Temperature normalization rates in the ibuprofen and dipyrone groups (78% and 82%, respectively) were significantly higher than the acetaminophen group (68%, P = 0.004)...
June 2001: Clinical Pediatrics
B Lell, M Sovric, D Schmid, D Luckner, K Herbich, H Y Long, W Graninger, P G Kremsner
A comparison of different antipyretics in children with malaria showed a small effect of naproxen, but not of metamizol, on the reduction of fever peaks. Antipyretic treatment had no effect on fever clearance and therefore should be used cautiously in the treatment of malaria.
March 1, 2001: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
N Linder, L Sirota, A Snapir, I Eisen, N Davidovitch, G Kaplan, A Barzilai
BACKGROUND: Although the onset of fever in children often prompts parents to seek immediate treatment, the general level of parental knowledge on pediatric fever and administration of antipyretic medications is unknown. Parents without a basic understanding of treatment principles may give their children incorrect doses of medication. Overdosing may cause drug toxicity, while underdosing may lead to unnecessary, repeated clinic and/or emergency room visits. OBJECTIVES: To assess parental decision-making with regard to treating fever in children, and its effectiveness, and to suggest methods for improving the level of treatment...
November 1999: Israel Medical Association Journal: IMAJ
T Izhar
OBJECTIVE: Efficacy, tolerability and safety of Dipyrone (Novalgin) in the management of pain and fever in children. SETTING: Open, non-comparative study in Ganga Ram Hospital, Lahore. SUBJECTS: Children (of both sexes) aged 3 months to 12 years with oral temperature of 38.5 degrees C or more/complaining of pain due to various reasons. RESULTS: Sixty-two (66.7%) out of 93 who had fever showed good response, 24 (25.8%) showed satisfactory response and 7 (7...
September 1999: JPMA. the Journal of the Pakistan Medical Association
J U Béria, C G Victora, F C Barros, A B Teixeira, C Lombardi
The consumption of medicines among a population-based cohort of 4,746 children born in 1982 in Pelotas, Brazil, was studied when the children were aged 3-4.5 years. Fifty six percent of the mothers reported that their children had taken one or more medicines during a two-week period; 29.5% of the products were fixed combinations of three or more components, (which was taken as an indicator of poor quality). Almost 10% of the children had used a given medicine for one month or more. Aspirin, combinations of vitamins and mineral supplements and cough and cold combinations were the medicines most frequently used...
April 1993: Revista de Saúde Pública
D Adam, G Stankov
Although the need for routine antipyretic therapy in children has often been questioned, there are no data to contra-indicate this. Not all fevers need to be treated but many physicians do so to relieve parental concern. The most commonly used antipyretic drugs are acetylsalicylic acid (ASA), paracetamol (acetaminophen) and dipyrone (metamizol). Paracetamol and ASA have been extensively evaluated but there are few clinical trials on dipyrone. In the last decade a strong statistical association has been observed between salicylates and Reye syndrome...
June 1994: European Journal of Pediatrics
A Dittmer
Fever should be treated according to the individual situation. Securing a sufficient fluid intake is the most important primary measure. The decrease of body temperature by physical means is efficient only in combination with drug therapy and presumes the control of blood circulation. Aminophenazon is the most efficient drug to lower fever. Metamizol should be prefered in children at risk for convulsive disorders. The combination of aminophenazon with phenothiazines can be recommended , prothazine is the drug of first choice in suitable cases a caudal treatment of fever with antiphlogistic drugs as diclophenacsodium (Voltaren) is indicated...
March 1981: Kinderärztliche Praxis
O V Liadkov, A G Lysov, N D Mariinskaia, M I Kanter
No abstract text is available yet for this article.
1991: Pediatriia
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