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https://www.readbyqxmd.com/read/28222251/prognostic-methylation-markers-for-overall-survival-in-cytogenetically-normal-patients-with-acute-myeloid-leukemia-treated-on-swog-trials
#1
Xiaoyu Qu, Megan Othus, Jerry Davison, Yu Wu, Liying Yan, Soheil Meshinchi, Fabiana Ostronoff, Elihu H Estey, Jerry P Radich, Harry P Erba, Frederick R Appelbaum, Min Fang
BACKGROUND: Aberrant DNA methylation is known to occur in patients with acute myeloid leukemia (AML), whereas methylation signatures and prognostic markers have been proposed. The objective of the current study was to evaluate all CpG sites of the genome and identify prognostic methylation markers for overall survival in patients with AML with normal karyotype (AML-NK). METHODS: AML-NK samples from 7 SWOG trials were analyzed using a novel genome-wide approach called "CHARMcox" (comprehensive high-throughput array-based relative methylation analysis combined with the Cox proportional hazards model) controlling for known clinical covariates...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28219241/alkyl-cyclens-as-effective-sulfur-and-phosphorus-free-friction-modifiers-for-boundary-lubrication
#2
Michael Desanker, Xingliang He, Jie Lu, Pinzhi Liu, David B Pickens, Massimiliano Delferro, Tobin J Marks, Yip-Wah Chung, Q Jane Wang
Modern automotive engines operate at higher power densities than ever before, driving a need for new lubricant additives capable of reducing friction and wear further than ever before while not poisoning the catalytic converter. Reported in this paper is a new class of molecular friction modifier (FM), represented by 1,4,7,10-tetradodecyl-1,4,7,10-tetraazacyclododecane (1a), designed to employ thermally stable, sulfur- and phosphorus-free alkyl substituted nitrogen heterocycles with multiple nitrogen centers per molecule...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28217420/acute-effects-of-different-self-massage-volumes-on-the-fms%C3%A2-overhead-deep-squat-performance
#3
Estêvão Rios Monteiro, Jakob Škarabot, Andrew D Vigotsky, Amanda Fernandes Brown, Thiago Matassoli Gomes, Jefferson da Silva Novaes
BACKGROUND: The Functional Movement Screen (FMS™) is a battery of tests designed to assess movement competency; the overhead deep squat test, specifically, has been shown to be an accurate predictor of overall FMS™ scores. Self-massage (SM) is a ubiquitous warm-up utilized to increase joint range of motion and, therefore, may be effective for improving performance of the overhead deep squat test. PURPOSE: To examine how different doses (30, 60, 90, and 120 seconds) of SM of different areas of the body (plantar fascia, latissimus dorsi, and lateral thigh) affects the score obtained on an overhead deep squat test...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28216083/maternal-vitamin-d-sufficiency-and-reduced-placental-gene-expression-in-angiogenic-biomarkers-related-to-comorbidities-of-pregnancy
#4
Elizabeth V Schulz, Lori Cruze, Wei Wei, John Gehris, Carol L Wagner
INTRODUCTION: Maternal circulating 25-hydroxyvitamin D [25(OH)D] has been shown to optimize production of 1,25-dihydroxyvitamin D [1,25(OH)2D] during pregnancy at approximately 100nmoles/L, which has pronounced effects on fetal health outcomes. Additionally, associations are noted between low maternal 25(OH)D concentrations and vascular pregnancy complications, such as preeclampsia. To further elucidate the effects of vitamin D activity in pregnancy, we investigated the role of maternal 25(OH)D, the nutritional indicator of vitamin D status, in relation to placental maintenance and, specifically, expression of placental gene targets related to angiogenesis and vitamin D metabolism...
February 12, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28213755/pedagogical-approaches-to-and-effects-of-fundamental-movement-skill-interventions-on-health-outcomes-a-systematic-review
#5
REVIEW
Claire Tompsett, Ross Sanders, Caitlin Taylor, Stephen Cobley
BACKGROUND: Fundamental movement skills (FMS) are assumed to be the basic prerequisite motor movements underpinning coordination of more integrated and advanced movement capabilities. FMS development and interventions have been associated with several beneficial health outcomes in individual studies. OBJECTIVE: The primary aim of this review was to identify FMS intervention characteristics that could be optimised to attain beneficial outcomes in children and adolescents, while the secondary aim was to update the evidence as to the efficacy of FMS interventions on physiological, psychological and behavioural health outcomes...
February 18, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28209359/safety-and-efficacy-of-fimasartan-in-mexican-patients-with-grade-1-2-essential-hypertension
#6
Ernesto G Cardona-Muñoz, Agustín López-Alvarado, Ignacio Conde-Carmona, Gerardo Sánchez-Mejorada, Sara Pascoe-González, Ramiro G Banda-Elizondo, Armando García-Castillo, Guillermo González-Gálvez, Raúl G Velasco-Sánchez, Maricela Vidrio-Velázquez, José L Leiva-Pons, Efraín Villeda-Espinosa, Arturo Guerra-López, Ramón M Esturau-Santalo
OBJECTIVE: To evaluate efficacy and safety of 60mg and 120mg Fimasartan (FMS) alone or combined with 12.5mg hydrochlorothiazide (HCTZ) in Mexican population. METHODS: Six month, treat-to-target, open study in subjects with grade 1-2 hypertension. Subjects were initially treated with 60mg FMS once daily; on week 8, those with Diastolic Blood Pressure (DBP) <90mmHg continued on the same FMS dose during the rest of the study while those with DBP ≥90mmHg were randomized to either 120mg FMS or 60mg FMS+12...
February 10, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28199380/the-effects-of-pravastatin-on-the-normal-human-placenta-lessons-from-ex-vivo-models
#7
Adelina Balan, Irit Szaingurten-Solodkin, Shani S Swissa, Valeria Feinshtein, Mahmoud Huleihel, Gershon Holcberg, Doron Dukler, Ofer Beharier
INTRODUCTION: Research in animal models and preliminary clinical studies in humans support the use of pravastatin for the prevention of preeclampsia. However, its use during pregnancy is still controversial due to limited data about its effect on the human placenta and fetus. METHODS: In the present study, human placental cotyledons were perfused in the absence or presence of pravastatin in the maternal reservoir (PraM). In addition, placental explants were treated with pravastatin for 5, 24 and 72 h under normoxia and hypoxia...
2017: PloS One
https://www.readbyqxmd.com/read/28195971/preseason-functional-movement-screen%C3%A2-predicts-risk-of-time-loss-injury-in-experienced-male-rugby-union-athletes
#8
Sean R Duke, Steve E Martin, Catherine A Gaul
The purpose of this study was to determine the relationship between Functional Movement Screen™ (FMS) score and the risk of time-loss injury in experienced male rugby union athletes. A secondary purpose was to determine the relationship between FMS-determined asymmetries and the risk of time-loss injury in these athletes.FMS scores were collected from male rugby union athletes (n=73) during preseason and half-way through one eight-month season. Time-loss injury data were collected throughout the full season...
February 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28194038/itd-mutation-in-flt3-tyrosine-kinase-promotes-warburg-effect-and-renders-therapeutic-sensitivity-to-glycolytic-inhibition
#9
H-Q Ju, G Zhan, A Huang, Y Sun, S Wen, J Yang, W-H Lu, R-H Xu, J Li, Y Li, G Garcia-Manero, P Huang, Y Hu
Internal tandem duplication (ITD) mutation in Fms-like tyrosine kinase 3 gene (FLT3/ITD) represents an unfavorable genetic change in acute myeloid leukemia (AML) and is associated with poor prognosis. Metabolic alterations have been involved in tumor progression and attracted interest as a target for therapeutic intervention. However, few studies analyzed the adaptations of cellular metabolism in the context of FLT3/ITD mutation. Here, we report that FLT3/ITD causes a significant increase in aerobic glycolysis through AKT-mediated upregulation of mitochondrial hexokinase (HK2), and renders the leukemia cells highly dependent on glycolysis and sensitive to pharmacological inhibition of glycolytic activity...
February 14, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28185526/low-expression-of-ash2l-protein-correlates-with-a-favorable-outcome-in-acute-myeloid-leukemia
#10
Jill S Butler, Yi Hua Qiu, Nianxiang Zhang, Suk-Young Yoo, Kevin R Coombes, Sharon Y R Dent, Steven M Kornblau
ASH2L encodes a trithorax group protein that is a core component of all characterized mammalian histone H3K4 methyltransferase complexes, including mixed lineage leukemia (MLL) complexes. ASH2L protein levels in primary leukemia patient samples have not yet been defined. We analyzed ASH2L protein expression in 511 primary AML patient samples using reverse phase protein array (RPPA) technology. We discovered that ASH2L expression is significantly increased in a subset of patients carrying fms-related tyrosine kinase 3 (FLT3) mutations...
May 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28169146/interventions-to-improve-fundamental-motor-skills-in-pre-school-aged-children-a-systematic-review-and-meta-analysis
#11
REVIEW
Abbey Van Capelle, Carolyn R Broderick, Nancy van Doorn, Rachel E Ward, Belinda J Parmenter
OBJECTIVES: Mastery in -fundamental motor skills (FMS) is associated with increased physical activity (PA) in school-aged children; however, there is limited research on pre-schoolers (3-5 years). We aimed to evaluate interventions for improving FMS as well as PA. DESIGN/METHODS: A search of electronic databases was conducted for controlled trials using PA interventions with FMS as outcomes in healthy pre-schoolers. Standardised mean difference (SMD), 95% confidence intervals and publication bias were calculated for each outcome using Revman 5...
January 23, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28167861/self-reported-childhood-maltreatment-and-traumatic-events-among-israeli-patients-suffering-from-fibromyalgia-and-rheumatoid-arthritis
#12
Raneen Hellou, Winfried Häuser, Inbal Brenner, Dan Buskila, Giris Jacob, Ori Elkayam, Valerie Aloush, Jacob N Ablin
Objective. The association between Fibromyalgia Syndrome (FMS) and childhood maltreatment and adversity has frequently been proposed but limited data exists regarding the transcultural nature of this association. Methods. 75 Israeli FMS patients and 23 Rheumatoid Arthritis (RA) patients were compared. Childhood maltreatment was assessed by the Childhood Trauma Questionnaire (CTQ) and potential depressive and anxiety disorders were assessed by the Patient Health Questionnaire-4. FMS severity was assessed by the Widespread Pain Index (WPI), the Symptom Severity Score (SSS), and the FIQ...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28167687/prediction-of-preeclampsia-using-the-soluble-fms-like-tyrosine-kinase-1-to-placental-growth-factor-ratio-a-prospective-cohort-study-of-unselected-nulliparous-women
#13
Ulla Sovio, Francesca Gaccioli, Emma Cook, Martin Hund, D Stephen Charnock-Jones, Gordon C S Smith
We sought to assess the ratio of sFlt-1 (soluble fms-like tyrosine kinase 1) to PlGF (placental growth factor) in maternal serum as a screening test for preeclampsia in unselected nulliparous women with a singleton pregnancy. We studied 4099 women recruited to the POP study (Pregnancy Outcome Prediction) (Cambridge, United Kingdom). The sFlt-1:PlGF ratio was measured using the Roche Cobas e411 platform at ≈20, ≈28, and ≈36 weeks of gestational age (wkGA). Screen positive was defined as an sFlt-1:PlGF ratio >38, but higher thresholds were also studied...
February 6, 2017: Hypertension
https://www.readbyqxmd.com/read/28166972/comparison-between-allantochorion-membrane-and-amniotic-sac-detection-by-per-rectal-palpation-for-pregnancy-diagnosis-on-pregnancy-loss-calving-rates-and-abnormalities-in-newborn-calves
#14
Juan E Romano, Pablo Pinedo, Kelsey Bryan, Roney S Ramos, Karol G Solano, Daniel Merchan, Juan Velez
The objectives of the present investigation were to evaluate the pregnancy diagnosis by detection of either the allantochorion membrane (FMS) or amniotic sac (ASP) by per rectum palpation (PRP) during late embryonic or early fetal period on pregnancy loss (PRL) at reexamination, calving rates, and abnormalities in newborn calves. A controlled randomized blind design with 800 lactating dairy pregnant cows diagnosed by transrectal ultrasonography (TRUS) between Days 35 and 57 of gestation from one dairy farm were included...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28164537/flt3-gene-mutation-profile-and-prognosis-in-adult-acute-myeloid-leukemia
#15
Aileen Azari-Yam, Javad Tavakkoly-Bazzaz, Yousef Semnani, Elham Davoudi-Dehaghani, Robabeh Ghodssi-Ghassemabadi, Soodeh Kianfar, Ameneh Saadat, Mahboobeh Masoudifard, Marjan Yaghmaie, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Sirous Zeinali
BACKGROUND: Internal tandem duplication (ITD) of FMS-related tyrosine kinase 3 (FLT3) gene, which occurs in exons 14 and 15, is one of the most prevalent somatic mutations in adult acute myeloid leukemia (AML) and has biological, prognostic, and therapeutic implications. The prognostic importance of codon 835 tyrosine kinase domain (TKD) mutation (exon 20), which occurs relatively frequently in adult AML, is often debated. We aimed to study the FLT3 gene mutation profile and prognosis in 139 adult Iranian patients with newly diagnosed AML...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164532/clinical-assessment-of-soluble-fms-like-tyrosine-kinase-1-placental-growth-factor-ratio-for-the-diagnostic-and-the-prognosis-of-preeclampsia-in-the-second-trimester
#16
Dalenda Chelli, Asma Hamdi, Sarah Saoudi, Amel A Jenayah, Armand Zagre, Haithem Jguerim, Channoufi Bedis, Ezzeddine Sfar
BACKGROUND: Preeclampsia is one of the most common and serious complications of pregnancy. Various reports have demonstrated that disturbances in angiogenic and antiangiogenic factors are implicated in its pathogenesis and have possible relevance in its diagnosis and prognosis. METHODS: In this case-control study, we enrolled 73 patients with 34 preeclamptic cases diagnosed according to clinical criteria and dosing of proteinuria. The cases were matched to controls at the same age and parity...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162450/-220-associations-between-heat-shock-protein-and-symptom-burden-in-fibromyalgia-syndrome-fms
#17
J Kawi, N Lukkahatai, A Espina, B Walitt, L Saligan
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161767/pain-extent-is-associated-with-pain-intensity-but-not-with-widespread-pressure-or-thermal-pain-sensitivity-in-women-with-fibromyalgia-syndrome
#18
Marco Barbero, César Fernández-de-Las-Peñas, María Palacios-Ceña, Corrado Cescon, Deborah Falla
Widespread pain is considered a sign of central sensitization in people with chronic pain. Our aim was to examine whether pain extent, assessed from the pain drawing, relates to measures from quantitative sensory testing in fibromyalgia syndrome (FMS). Thirty women with FMS and no other co-morbid conditions completed pain drawings (dorsal and ventral views) and clinical and related disability questionnaires. Pain extent and pain frequency maps were obtained from the pain drawings using a novel customized software...
February 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28159598/predictive-value-of-pretransplantation-molecular-minimal-residual-disease-assessment-by-wt1-gene-expression-in-flt3-positive-acute-myeloid-leukemia
#19
Anna Candoni, Federico De Marchi, Francesca Zanini, Maria Elena Zannier, Erica Simeone, Eleonora Toffoletti, Alexsia Chiarvesio, Michela Cerno, Carla Filì, Francesca Patriarca, Renato Fanin
The FMS-like tyrosine kinase 3 (FLT3) mutation in acute myeloid leukemia (AML) is a negative prognostic factor and, in these cases, allogeneic stem cell transplantation (allo-SCT) can represent an important therapeutic option, especially if performed in complete remission (CR). However, it is increasingly clear that not all cytological CRs (cCRs) are the same and that minimal residual disease (MRD) before allo-SCT could have an impact on AML outcome. Unfortunately, FLT3, due its instability of expression, is still not considered a good molecular MRD marker...
February 1, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28158152/effects-of-dry-needling-on-spinal-mobility-and-trigger-points-in-patients-with-fibromyalgia-syndrome
#20
Adelaida Maria Castro-Sanchez, Hector Garcia-Lopez, Guillermo A Mataran-Penarrocha, Manuel Fernandez-Sanchez, Cayetano Fernandez-Sola, Jose Granero-Molina, Maria Encarnacion Aguilar-Ferrandiz
BACKGROUND: The etiology of fibromyalgia syndrome (FMS) is inconclusive, but central mechanisms are well accepted for this pain condition. Myofascial pain syndrome (MPS) is one of the most common musculoskeletal pain diseases and is characterized by myofascial trigger points (MTrPs). It has been suggest that MTrPs have an important factor in the genesis of FMS. OBJECTIVE: The purpose of the current randomized clinical trial was to compare the effectiveness of dry needling versus cross tape on spinal mobility and MTrPs in spinal muscles in patients with FMS...
February 2017: Pain Physician
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