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https://www.readbyqxmd.com/read/28522227/promoting-motor-skills-in-low-income-ethnic-children-the-physical-activity-in-linguistically-diverse-communities-paldc-nonrandomized-trial
#1
Anthony D Okely, Louise L Hardy, Marijka Batterham, Phillip Pearson, Kim McKeen, Lauren Puglisi
OBJECTIVES: This study reports the long-term effects of a professional learning program for classroom teachers on fundamental motor skill (FMS) proficiency of primary school students from ethnically diverse backgrounds. DESIGN: A cluster non-randomized trial using a nested cross-sectional design. METHODS: The study was conducted in 8 primary schools located in disadvantaged and culturally diverse areas in Sydney, Australia. The intervention used an action learning framework, with each school developing and implementing an action plan for enhancing the teaching of FMS in their school...
May 8, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28516360/gilteritinib-a-flt3-axl-inhibitor-shows-antileukemic-activity-in-mouse-models-of-flt3-mutated-acute-myeloid-leukemia
#2
Masamichi Mori, Naoki Kaneko, Yoko Ueno, Masaki Yamada, Ruriko Tanaka, Rika Saito, Itsuro Shimada, Kenichi Mori, Sadao Kuromitsu
Advances in the understanding of the molecular basis for acute myeloid leukemia (AML) have generated new potential targets for treatment. Fms-like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes in AML and mutations in this gene are associated with poor overall survival. AXL plays a role in the activation of FLT3 and has been implicated in the pathogenesis of AML. The studies reported here evaluated the ability of a novel FLT3/AXL inhibitor, gilteritinib, to block mutated FLT3 in cellular and animal models of AML...
May 17, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28515971/prediction-of-functional-movement-screen%C3%A2-performance-from-lower-extremity-range-of-motion-and-core-tests
#3
Nicole J Chimera, Shelby Knoeller, Ron Cooper, Nicholas Kothe, Craig Smith, Meghan Warren
BACKGROUND: There are varied reports in the literature regarding the association of the Functional Movement Screen™ (FMS™) with injury. The FMS™ has been correlated with hamstring range of motion and plank hold times; however, limited research is available on the predictability of lower extremity range of motion (ROM) and core function on FMS™ performance. PURPOSE/HYPOTHESES: The purpose of this study was to examine whether active lower extremity ROM measurements and core functional tests predict FMS™ performance...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28506451/motor-skill-development-in-low-income-at-risk-preschoolers-a-community-based-longitudinal-intervention-study
#4
Laura L Bellows, Patricia L Davies, Jimikaye B Courtney, William J Gavin, Susan L Johnson, Richard E Boles
OBJECTIVES: This study aimed to: (1) determine the status of fundamental movement skill (FMS) performance in low-income, at-risk preschoolers; and (2) evaluate the impact of the Food Friends Get Movin' with Mighty Moves (MM) program on improving children's FMS at two-year follow-up. DESIGN: Longitudinal, quasi-experimental study with matched controls. METHODS: The Colorado LEAP study was conducted in four Head Start/preschools (two intervention, two control) serving children aged 3-5 years...
April 26, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28504910/fermented-moringa-oleifera-decreases-hepatic-adiposity-and-ameliorates-glucose-intolerance-in-high-fat-diet-induced-obese-mice
#5
Hyunchae Joung, Bobae Kim, Hyunjoon Park, Kyuyeon Lee, Hee-Hoon Kim, Ho-Cheol Sim, Hyun-Jin Do, Chang-Kee Hyun, Myoung-Sool Do
Metabolic diseases, such as glucose intolerance and nonalcoholic fatty-liver disease (NAFLD), are primary risk factors for life-threatening conditions such as diabetes, heart attack, stroke, and hepatic cancer. Extracts from the tropical tree Moringa oleifera show antidiabetic, antioxidant, anti-inflammatory, and anticancer effects. Fermentation can further improve the safety and nutritional value of certain foods. We investigated the efficacy of fermented M. oleifera extract (FM) against high-fat diet (HFD)-induced glucose intolerance and hepatic lipid accumulation and investigated the underlying mechanisms by analyzing expression of proteins and genes involved in glucose and lipid regulation...
May 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28502698/effectiveness-of-a-fine-motor-skills-rehabilitation-program-on-upper-limb-disability-manual-dexterity-pinch-strength-range-of-fingers-motion-performance-in-activities-of-daily-living-functional-independency-and-general-self-efficacy-in-hand-osteoarthritis-a
#6
Jose Manuel Pérez-Mármol, Ma Carmen García-Ríos, María Azucena Ortega-Valdivieso, Enrique Elías Cano-Deltell, María Isabel Peralta-Ramírez, Kelly Ickmans, María Encarnación Aguilar-Ferrándiz
STUDY DESIGN: A randomized clinical trial. INTRODUCTION: Rehabilitation treatments for improving fine motor skills (FMS) in hand osteoarthritis (HOA) have not been well explored yet. PURPOSE OF THE STUDY: To assess the effectiveness of a rehabilitation program on upper limb disability, independence of activities of daily living (ADLs), fine motor abilities, functional independency, and general self-efficacy in older adults with HOA. METHODS: About 45 adults (74-86 years) with HOA were assigned to an experimental group for completing an FMS intervention or a control group receiving conventional occupational therapy...
May 11, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28500309/resveratrol-inhibits-release-of-soluble-fms-like-tyrosine-kinase-sflt-1-and-soluble-endoglin-and-improves-vascular-dysfunction-implications-as-a-preeclampsia-treatment
#7
Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Minh Deo, Sally Beard, Tuong V Nguyen, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino
Preeclampsia is a disease of pregnancy associated with placental oxidative stress, inflammation and elevated release of anti-angiogenic factors sFlt-1 and soluble endoglin. These placental factors cause generalized maternal endothelial dysfunction. There are no treatments to halt disease progression; delivery is the only cure. Resveratrol modulates pathways involved in inflammation and oxidative stress and may offer a potential therapeutic for preeclampsia. Resveratrol reduced sFlt-1, sFlt-1 e15a and soluble endoglin secretion from primary trophoblasts and HUVECs and reduced mRNA expression of pro-inflammatory molecules NFκB, IL-6 and IL-1β in trophoblasts...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28498310/selective-expression-of-flt3-within-the-mouse-hematopoietic-stem-cell-compartment
#8
Ciaran James Mooney, Alan Cunningham, Panagiotis Tsapogas, Kai-Michael Toellner, Geoffrey Brown
The fms-like tyrosine kinase 3 (Flt3) is a cell surface receptor that is expressed by various hematopoietic progenitor cells (HPC) and Flt3-activating mutations are commonly present in acute myeloid and lymphoid leukemias. These findings underscore the importance of Flt3 to steady-state and malignant hematopoiesis. In this study, the expression of Flt3 protein and Flt3 mRNA by single cells within the hematopoietic stem cell (HSC) and HPC bone marrow compartments of C57/BL6 mice was investigated using flow cytometry and the quantitative reverse transcription polymerase chain reaction...
May 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28498175/experiences-of-healthcare-professionals-of-having-their-significant-other-admitted-to-an-acute-care-facility-a-qualitative-systematic-review
#9
Hussamaldeen Sabyani, Richard Wiechula, Judy Magarey, Frank Donnelly
BACKGROUND: Most healthcare professionals at some time will experience having a significant other admitted to an acute care hospital. The knowledge and understanding that these individuals possess because of their professional practice can potentially alter this experience. Expectations of staff and other family members (FMs) can potentially increase the burden on these health professionals. All FMs of patients should have their needs and expectations considered; however, this review specifically addresses what may be unique for healthcare professionals...
May 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28494174/human-endometrial-stromal-cell-plasticity-reversible-sflt1-expression-negatively-coincides-with-decidualization
#10
Hanh N Cottrell, JuanJuan Wu, Bassam H Rimawi, Juan Manuel Duran, Jessica B Spencer, Neil Sidell, Augustine Rajakumar
Preeclampsia (PE) is a major complication of pregnancy in which the placenta is known to have shallow implantation into the uterine decidua. Studies have implicated soluble fms-like tyrosine kinase-1 (sFlt1), a soluble vascular endothelial growth factor (VEGF) receptor protein, in the pathogenesis of PE. sFlt1 has the ability to bind to and neutralize the angiogenic functions of VEGF and placental growth factor (PlGF). The presence of sFlt1 and its action in the endometrium is yet to be determined. We hypothesize that endometrial stromal cells (ESC) at the maternal-fetal interface may play a role in sFlt-1 regulation during pregnancy...
May 11, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28493226/-etiology-and-pathophysiology-of-fibromyalgia-syndrome-updated-guidelines-2017-overview-of-systematic-review-articles-and-overview-of-studies-on-small-fiber-neuropathy-in-fms-subgroups
#11
N Üçeyler, M Burgmer, E Friedel, W Greiner, F Petzke, M Sarholz, M Schiltenwolf, A Winkelmann, C Sommer, W Häuser
BACKGROUND: The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was planned for April 2017. METHODS: The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest...
May 10, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28492503/synthetic-receptors-induce-anti-angiogenic-and-stress-signaling-on-human-first-trimester-cytotrophoblast-cells
#12
Ahmed F Pantho, Mason Price, Ahm Zuberi Ashraf, Umaima Wajid, Maryam Emami Khansari, Afsana Jahan, Syeda H Afroze, Md Mhahabubur Rhaman, Corey R Johnson, Thomas J Kuehl, Md Alamgir Hossain, Mohammad Nasir Uddin
The cytotrophoblast (CTB) cells of the human placenta have membrane receptors that bind certain cardiotonic steroids (CTS) found in blood plasma. One of these, marinobufagenin, is a key factor in the etiology of preeclampsia. Herein, we used synthetic receptors (SR) to study their effectiveness on the angiogenic profile of human first trimester CTB cells. The humanextravillous CTB cells (Sw.71) used in this study were derived from first trimester chorionic villus tissue. Culture media of CTB cells treated with ≥1 nM SR level revealed sFlt-1 (Soluble fms-like tyrosine kinase-1) was significantly increased while VEGF (vascular endothelial growth factor) was significantly decreased in the culture media (* p < 0...
May 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28490644/background-noise-exerts-diverse-effects-on-the-cortical-encoding-of-foreground-sounds
#13
Brian James Malone, Marc A Heiser, Ralph Eugene Beitel, Christoph E Schreiner
In natural listening conditions, many sounds must be detected and identified in the context of competing sound sources which function as background noise. Traditionally, noise is thought to degrade the cortical representation of sounds by suppressing responses and increasing response variability. However, recent studies of neural network models and brain slices have shown that background synaptic noise can improve the detection of signals. Because acoustic noise affects the synaptic background activity of cortical networks, it may improve the cortical responses to signals...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490352/a-diagnostic-biomarker-profile-for-fibromyalgia-syndrome-based-on-an-nmr-metabolomics-study-of-selected-patients-and-controls
#14
Bontle G Malatji, Helgard Meyer, Shayne Mason, Udo F H Engelke, Ron A Wevers, Mari van Reenen, Carolus J Reinecke
BACKGROUND: Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a continuing endeavour in FMS research. Our objective was to perform an explorative metabolomics study (1) to elucidate the global urinary metabolite profile of patients suffering from FMS, and (2) to explore the potential of this metabolite information to augment existing medical practice in diagnosing the disease...
May 11, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28487140/feasibility-and-efficacy-of-the-great-leaders-active-students-glass-program-on-children-s-physical-activity-and-object-control-skill-competency-a-non-randomised-trial
#15
Nicole Nathan, Rachel Sutherland, Mark R Beauchamp, Kristen Cohen, Ryan M Hulteen, Mark Babic, Luke Wolfenden, David R Lubans
OBJECTIVES: This study aimed to assess the feasibility and efficacy of the Great Leaders Active StudentS (GLASS) program, a school-based peer-led physical activity and object control skill intervention. DESIGN: The study employed a quasi-experimental design. METHODS: The study was conducted in two elementary schools, one intervention and one comparison, in Newcastle, New South Wales (NSW), Australia from April to June 2015 (N=224 students)...
April 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28476569/design-and-synthesis-of-a-fluorinated-quinazoline-based-type-ii-trk-inhibitor-as-a-scaffold-for-pet-radiotracer-development
#16
Vadim Bernard-Gauthier, Anne Mahringer, Matthew Vesnaver, Gert Fricker, Ralf Schirrmacher
NTRK1/2/3 fusions have recently been characterized as low incidence oncogenic alterations across various tumor histologies. Tyrosine kinase inhibitors (TKIs) of the tropomyosin receptor kinase family TrkA/B/C (encoded by NTRK1/2/3) are showing promises in the clinic for the treatment of cancer patients whose diseases harbor NTRK tumor drivers. We describe herein the development of [(18)F]QMICF ([(18)F]-(R)-9), a quinazoline-based type-II pan-Trk radiotracer with nanomolar potencies for TrkA/B/C (IC50=85-650nM) and relevant TrkA fusions including TrkA-TPM3 (IC50=162nM)...
April 21, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28474988/premedication-with-fentanyl-midazolam-improves-sevoflurane-anesthesia-for-surgical-intervention-in-laboratory-mice
#17
Miriam Lipiski, Margarete Arras, Paulin Jirkof, Nikola Cesarovic
Balanced anesthesia allows for a reduced dosage of each component, while inducing general anesthesia of sufficient depth with potentially fewer side effects. Here, we compare two anesthetic protocols combining sevoflurane anesthesia with pre-medication (ketamine [K] or fentanyl-midazolam [FM]) to a sevoflurane monoanesthesia (S) concerning their ability to provide reliable anesthesia suitable for moderate surgery in laboratory mice. Twenty-one female C57BL/6J mice assigned randomly to one of three protocols underwent a 50-min anesthesia and a sham embryo transfer...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28472389/carbon-monoxide-releasing-molecules-blunt-placental-ischemia-induced-hypertension
#18
Eric M George, Kathy Cockrell, Marietta Arany, David E Stec, John M Rimoldi, Rama S V Gadepalli, Joey P Granger
BACKGROUND: Preeclampsia is a pregnancy complication which manifests as new-onset hypertension, proteinuria, and a spectrum of other symptoms. While the underlying causes are still a subject of much debate, it is commonly believed that placental ischemia is a central cause. The ischemic placenta secretes factors which are believed to be responsible for the maternal syndrome; most notably the anti-angiogenic protein soluble fms-like tyrosine kinase 1 (sFlt-1). We have reported that induction of the carbon monoxide (CO) producing protein heme oxygenase-1 restored angiogenic imbalance and reduced blood pressure in a rat model of placental ischemia, and that CO blocks hypoxia-induced sFlt-1 production from placental tissue in vitro...
May 2, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28470536/flt3-itd-and-its-current-role-in-acute-myeloid-leukaemia
#19
REVIEW
Francisco Alejandro Lagunas-Rangel, Venice Chávez-Valencia
FMS-like tyrosine kinase 3 (FLT3) is a proto-oncogene involved in crucial steps of haematopoiesis such as proliferation, differentiation and survival. In recent years, FLT3 has been an important marker in different haematological malignancies, highlighting in acute myeloid leukaemia, where FLT3 mutations have been associated with the clinical prognosis, treatment and survival of patients. The most common form of FLT3 mutation is an internal tandem duplication (ITD) that promotes ligand-independent auto-phosphorylation and constitutive activation of the receptor...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28468595/sflt-1-inhibits-proliferation-migration-and-invasion-of-colorectal-cancer-sw480-cells-through-vascular-mimicry-formation-suppression
#20
Wang Jinjun, Wang Zhaowei, Li Qiang, Xue Zhijun, Zhang Juanzi, Li Lin, Jiang Guixi
To investigate the effects of soluble fms-like tyrosine kinase-1 on the vascular mimicry formation, proliferation, migration, and invasion of colorectal cancer SW480 cells. The recombinant plasmid pBLAST49-sFLT-1 or pBLAST49 control plasmid was transfected into SW480 cells to obtain hsFLT-1-SW480 or Ctrl-SW480 cells. The three-dimensional model culture, sulforhodamine B assay, scratch assay, and Transwell assay were performed to detect the vascular mimicry formation, proliferation, migration, and invasion of colorectal cancer SW480 cells, respectively...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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