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https://www.readbyqxmd.com/read/28028682/interstitial-lung-disease-increases-mortality-in-systemic-sclerosis-patients-with-pulmonary-arterial-hypertension-without-affecting-hemodynamics-and-exercise-capacity
#1
M Michelfelder, M Becker, A Riedlinger, E Siegert, D Drömann, X Yu, F Petersen, G Riemekasten
Published data suggest that coexisting interstitial lung disease (ILD) has an impact on mortality in patients with systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH), but there is scarce knowledge if this is reflected by hemodynamics, exercise capacity, autoantibody profile, or pulmonary function. In this partially retrospective study, 27 SSc-PAH patients were compared to 24 SSc-PAH patients with coexisting ILD respecting to survival, pulmonary function, hemodynamics, exercise capacity, and laboratory parameters...
December 27, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/28026153/clinical-and-hemodynamic-characteristics-of-pulmonary-hypertension-associated-with-interstitial-lung-disease-in-china
#2
Lan Wang, Qin-Hua Zhao, Bigyan Pudasaini, Rong Jiang, Su-Gang Gong, Jing He, Ping Yuan, Jin-Ming Liu
BACKGROUND: Pulmonary hypertension (PH) is an important complication of interstitial lung disease (ILD). The aim of the present study was to investigate characteristics and prognosis of ILD associated PH in a predominantly Chinese patient cohort. METHODS: Consecutive patients with ILD associated PH, confirmed by right heart catheterization at shanghai pulmonary hospital were included in the study. Characteristics at baseline and during follow-up, as well as survival, were analyzed...
December 27, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27996217/supervised-exercise-training-improves-exercise-cardiovascular-function-in-idiopathic-pulmonary-fibrosis
#3
Baruch Vainshelboim, Mordechai R Kramer, Benjamin D Fox, Shimon Izhakian, Alexander Sagie, Jose Oliveira
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal interstitial lung disease associated with cardiovascular impairments which compromise exercise tolerance and worsen prognosis. AIM: To examine the effect of participating in supervised exercise training (ET) program on cardiovascular function in patients with IPF. DESIGN: A randomized controlled study. SETTINGS: Outpatient hospital. POPULATION: Thirty-two IPF patients (68±8 yr)...
December 19, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27833411/the-impact-of-iterative-reconstruction-in-low-dose-computed-tomography-on-the-evaluation-of-diffuse-interstitial-lung-disease
#4
Hyun-Ju Lim, Myung Jin Chung, Kyung Eun Shin, Hye Sun Hwang, Kyung Soo Lee
OBJECTIVE: To evaluate the impact of iterative reconstruction (IR) on the assessment of diffuse interstitial lung disease (DILD) using CT. MATERIALS AND METHODS: An American College of Radiology (ACR) phantom (module 4 to assess spatial resolution) was scanned with 10-100 effective mAs at 120 kVp. The images were reconstructed using filtered back projection (FBP), adaptive statistical iterative reconstruction (ASIR), with blending ratios of 0%, 30%, 70% and 100%, and model-based iterative reconstruction (MBIR), and their spatial resolution was objectively assessed by the line pair structure method...
November 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27830441/successful-use-of-veno-venous-extracorporeal-membrane-oxygenation-as-a-bridge-to-lung-t-transplantation-in-a-patient-with-pulmonary-fibrosis
#5
Nao Umei, Shingo Ichiba, Masayuki Chida
As the Japanese organ donor allocation system does not permit the allocation of lungs at a priority level to patients on extracorporeal membrane oxygenation (ECMO), many of these patients die before suitable donor lungs become available. We report our first experience with ECMO as a bridge to lung transplantation (LTx) from a brain-dead donor. A 40-year-old man with interstitial lung disease who was listed for LTx 3 years previously, experienced progressive deterioration of respiratory function. He was mechanically ventilated at another hospital and was transported to our hospital due to severe hypoxemia...
November 9, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27818024/exertional-dyspnoea-in-chronic-respiratory-diseases-from-physiology-to-clinical-application
#6
Bruno-Pierre Dubé, François Vermeulen, Pierantonio Laveneziana
Dyspnoea is a complex, highly personalized and multidimensional sensory experience, and its underlying cause and mechanisms are still being investigated. Exertional dyspnoea is one of the most frequently encountered symptoms of patients with cardiopulmonary diseases, and is a common reason for seeking medical help. As the symptom usually progresses with the underlying disease, it can lead to an avoidance of physical activity, peripheral muscle deconditioning and decreased quality of life. Dyspnoea is closely associated with quality of life, exercise (in)tolerance and prognosis in various conditions, including chronic obstructive pulmonary disease, heart failure, interstitial lung disease and pulmonary hypertension, and is therefore an important therapeutic target...
November 3, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27766905/chronic-breathlessness-in-patients-with-idiopathic-pulmonary-fibrosis-a-major-challenge-for-caregivers
#7
Denis E O'Donnell, J Alberto Neder, Ingrid Harle, Onofre Moran-Mendoza
Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease, with a median survival time of two to five years. Most patients with IPF experience chronic breathlessness, which is closely linked to poor perceived quality of life and significant restriction of daily activities; therefore, effective management of this distressing symptom is a major goal of patient care. Areas covered: This report summarizes the physiology of IPF during rest and exercise, outlines current concepts of the mechanisms of breathlessness, and provides a physiological rationale for optimal management of individual patients...
December 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27686729/molecular-mechanisms-underlying-fibrosis-and-elastin-destruction-in-childhood-interstitial-lung-diseases
#8
Enas A Hamed, Mostafa M El-Saied, Khaled Saad, Hazem Abu-Zeid Yousef, Amany O Mohamed, Dina Sabry
OBJECTIVE: This study aimed to evaluate fibrosis and elastin destruction in childhood interstitial lung disease (chILD) patients. METHODS: Sixty patients and twenty healthy children were recruited. On admission, evaluation of chILD severity was made using Fan chILD score. Participants provided urine and blood samples. Plasma levels of transforming growth factor (TGF)-β1, connective tissue growth factor (CCN2), soluble factor related apoptosis (sFas) and long non-coding RNAs and urinary levels of desmosine/urinary creatinine (UDes/UCr) were measured...
September 21, 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/27552344/physical-activity-and-training-in-sarcoidosis-review-and-experience-based-recommendations
#9
Bert Strookappe, Lesley Ann Saketkoo, Marjon Elfferich, Anne Holland, Jolanda De Vries, Ton Knevel, Marjolein Drent
INTRODUCTION: Sarcoidosis is a multisystemic inflammatory disorder with a great variety of symptoms, including fatigue, dyspnea, pain, reduced exercise tolerance and muscle strength. Physical training has the potential to improve exercise capacity and muscle strength, and reduce fatigue. The aim of this review and survey was to present information about the role of physical training in sarcoidosis and offer practical guidelines. AREAS COVERED: A systematic literature review guided an international consensus effort among sarcoidosis experts to establish practice-basic recommendations for the implementation of exercise as treatment for patients with various manifestations of sarcoidosis...
October 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27550926/original-research-ace2-activator-associated-with-physical-exercise-potentiates-the-reduction-of-pulmonary-fibrosis
#10
Luana O Prata, Carolina R Rodrigues, Jéssica M Martins, Paula C Vasconcelos, Fabrício Marcus S Oliveira, Anderson J Ferreira, Maria da Glória Rodrigues-Machado, Marcelo V Caliari
The interstitial lung diseases are poorly understood and there are currently no studies evaluating the association of physical exercise with an ACE2 activator (DIZE) as a possible treatment for this group of diseases. We evaluate the effects of pharmacological treatment with an angiotensin-converting enzyme 2 activator drug, associated with exercise, on the pulmonary lesions induced by bleomycin. From the 96 male Balb/c mice used in the experiment, only 49 received 8 U/kg of bleomycin (BLM, intratracheally)...
January 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27537734/bosentan-for-digital-ulcers-prevention-does-not-worsen-cardiopulmonary-exercise-test-parameters-in-ssc-patients-with-interstitial-lung-disease
#11
Antonella Romaniello, Antonietta Gigante, Marcello Di Paolo, Gaia Tallerini, Biagio Barbano, Daria Amoroso, Paolo Palange, Edoardo Rosato
No abstract text is available yet for this article.
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27537719/exercise-related-ventilation-dynamics-and-clinical-correlates-in-patients-with-fibrotic-idiopathic-interstitial-pneumonias
#12
Marina De Martino, Raffaele Cobuccio, Dario Bruzzese, Gaetano Rea, Ilernando Meoli, Francesco Stefanelli, Angelo Canora, Annalisa Capaccio, Alessandro Sanduzzi, Alessandro Matarese, Marialuisa Bocchino
Assessment of exercise performance is a key component in the management of interstitial lung diseases, as its limitation may occur very early. Aim of the present study was to assess ventilation dynamics in combination with pulse-oximetry changes in 54 clinically stable patients affected by idiopathic pulmonary fibrosis or idiopathic fibrotic nonspecific interstitial pneumonia. Testing was successfully performed with the Spiropalm 6-MWT Hand-held spirometer by the majority of cases (94%). End test oxygen saturation (SpO2) values <88% were common in most of patients (76%), with a mean distance walked of 403 meters...
August 1, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27434081/cardiorespiratory-response-to-different-exercise-tests-in-interstitial-lung-disease
#13
Baptiste Chéhère, Valérie Bougault, Alice Gicquello, Benoit Wallaert
INTRODUCTION: The 6-minute stepper test (6MST) has been used as an alternative to the 6-minute walk test (6MWT) to assess exercise tolerance in patients with interstitial lung disease (ILD). Recent data suggest that the tests may involve different energy pathways and cardiorespiratory responses. We thus aimed to compare the cardiorespiratory responses of ILD patients during the 6MWT and the 6MST. METHODS: Thirty-one patients with ILD were randomised to perform both tests in the order 6MST→6MWT (n=16) or 6MWT→6MST (n=15)...
July 18, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27402855/duration-of-benefit-following-completion-of-pulmonary-rehabilitation-in-interstitial-lung-disease-an-observational-study
#14
C Sharp, M McCabe, M J Hussain, J W Dodd, H Lamb, H Adamali, A B Millar, D Smith
Background - It remains unclear for how long the benefits of pulmonary rehabilitation (PR) last in interstitial lung disease (ILD). An increasing number of ILD patients complete PR and it is vital they be offered the most beneficial approaches.Methods - This is a retrospective, observational study of a cohort with ILD who had completed PR. Incremental shuttle walk (ISWT) and chronic respiratory disease questionnaire (CRDQ) were compared before PR, at course completion, and 6/12 months follow-up. Focus group discussions with ILD participants who had completed PR and their carers established qualitative views on existing and potential future PR provision...
July 10, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27383922/ambulatory-and-short-burst-oxygen-for-interstitial-lung-disease
#15
REVIEW
Charles Sharp, Huzaifa Adamali, Ann B Millar
BACKGROUND: A large subgroup of people with interstitial lung disease (ILD) are normoxic at rest, but rapidly desaturate on exertion. This can limit exercise capacity and worsen dyspnoea. The use of ambulatory or short-burst oxygen when mobilising or during other activities, may improve exercise capacity and relieve dyspnoea. OBJECTIVES: To determine the effects of ambulatory and short-burst oxygen therapy, separately, on exercise capacity, dyspnoea and quality of life in people who have interstitial lung disease (ILD), particularly those with idiopathic pulmonary fibrosis (IPF)...
July 6, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27296820/predictors-of-fatigue-in-sarcoidosis-the-value-of-exercise-testing
#16
Bert Strookappe, Jolanda De Vries, Marjon Elfferich, Petra Kuijpers, Ton Knevel, Marjolein Drent
BACKGROUND: Sarcoidosis patients often are troubled by dyspnea, exercise limitation, and fatigue. Many patients (up to 50-81%) suffer from sarcoidosis-associated fatigue. The etiology of fatigue in sarcoidosis is still unclear. OBJECTIVE: The aim of this study was to assess the relationship between fatigue and both exercise capacity and clinical characteristics in sarcoidosis patients. Additionally, we studied the predictive value of exercise test results and other relevant clinical characteristics for the independent variable of fatigue...
July 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27257148/idiopathic-pulmonary-fibrosis-an-australian-perspective
#17
J Prasad, A E Holland, I Glaspole, G Westall
Idiopathic pulmonary fibrosis is a progressive interstitial lung disease of unknown aetiology with a dismal median survival of 3 years. Patients typically develop progressive dyspnoea and increasing exercise limitation. With a rising incidence and prevalence, an unpredictable disease course and limited treatment options, it is rapidly becoming an important public health concern. To date, lung transplantation has been the sole viable hope for treatment for those who qualify. However, the landscape of idiopathic pulmonary fibrosis management is changing, with the recent emergence of novel pharmacotherapy shown to have a favourable influence on the natural history of this disease...
June 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27173103/effect-of-long-term-treatment-with-corticosteroids-on-skeletal-muscle-strength-functional-exercise-capacity-and-health-status-in-patients-with-interstitial-lung-disease
#18
Masatoshi Hanada, Noriho Sakamoto, Yuji Ishimatsu, Tomoyuki Kakugawa, Yasushi Obase, Ryo Kozu, Hideaki Senjyu, Koichi Izumikawa, Hiroshi Mukae, Shigeru Kohno
BACKGROUND AND OBJECTIVE: Corticosteroids are occasionally used in the treatment of ILD. Chronic corticosteroid administration induces skeletal muscle weakness. However, it is unclear whether chronic corticosteroid treatment could further reduce skeletal muscle strength in patients with ILD who are weaker than healthy controls. The aim of this study was to determine the effects of chronic corticosteroid administration on skeletal muscle strength, exercise capacity, activities of daily living (ADL) and health status in ILD patients...
August 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27165419/the-prognostic-role-of-ventilatory-inefficiency-and-exercise-capacity-in-idiopathic-pulmonary-fibrosis
#19
Baruch Vainshelboim, Jose Oliveira, Benjamin Daniel Fox, Mordechai Reuven Kramer
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal interstitial lung disease associated with poor prognosis and limited effective treatment options. Reliable predictors of outcome in daily clinical practice are needed to determine high-risk patients for urgent lung transplantation referral. This study aimed to identify practical prognostic predictors of mortality using cardiopulmonary exercise testing (CPET) in IPF subjects. METHODS: Thirty-four subjects with IPF (22 men and 12 women), median age 68 (range 50-81) y were prospectively studied...
August 2016: Respiratory Care
https://www.readbyqxmd.com/read/27057932/six-minute-walk-test-in-systemic-sclerosis-a-systematic-review-and-meta-analysis
#20
Els Vandecasteele, Michel De Pauw, Filip De Keyser, Saskia Decuman, Ellen Deschepper, Yves Piette, Guy Brusselle, Vanessa Smith
BACKGROUND: Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are the leading causes of death in systemic sclerosis (SSc). Although the six-minute walk test (6MWT) is generally used for evaluating PAH and ILD, utility in SSc is undetermined. This study evaluates the role of 6MWT in SSc by systematic review and meta-analysis. METHODS: A systematic literature search on PubMed, Web of Science and Cochrane Library Online was performed using the medical subject heading search terms for "systemic sclerosis", "CREST" and "six minute walk test", "six minute walk distance (6MWD)", "(cardiopulmonary) exercise test", "treadmill test" or "step test"...
June 1, 2016: International Journal of Cardiology
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