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https://www.readbyqxmd.com/read/29210749/pulmonary-rehabilitation-for-patients-with-acute-chronic-obstructive-pulmonary-disease-exacerbations-is-the-evidence-strengthening
#1
Lissa Spencer
PURPOSE OF REVIEW: This manuscript aims to review the most recent evidence about the benefits of early pulmonary rehabilitation commenced during an acute exacerbation in people with COPD (AECOPD). RECENT FINDINGS: A number of RCTs and an observational study, published between 2015 and 2017, have used different exercise interventions compared with usual medical care in people with moderate-to-severe COPD during an AECOPD. The results show short-term improvement in walking distance, muscle strength, quality of life and anxiety and depression...
November 27, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29210599/obesity-in-copd-revealed-and-unrevealed-issues
#2
S Zewari, P Vos, F van den Elshout, R Dekhuijzen, Y Heijdra
The interactions between obesity and chronic obstructive pulmonary disease (COPD) are being increasingly explored. In part, this is due to the globally increasing prevalence rates of obesity. The prevalence of obesity in COPD patients is variable, and it seems that obesity is more common in COPD patients compared with subjects who do not have COPD. However, further studies are encouraged in this area due to observed inconsistencies in the current data. In this review, we focus on the knowledge of the effects of obesity on dyspnea, pulmonary function, exercise capacity and exacerbation risk...
December 2017: COPD
https://www.readbyqxmd.com/read/29209514/fish-oil-supplementation-in-chronic-obstructive-pulmonary-disease-feasibility-of-conducting-a-randomised-controlled-trial
#3
Ashley S Fulton, Alison M Coates, Marie T Williams, Peter R C Howe, Manohar L Garg, Lisa G Wood, Peter Frith, Alison M Hill
Background: Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) may act as an effective adjunct therapy for chronic obstructive pulmonary disease (COPD), a condition characterised by persistent airflow limitation and inflammation. However, the nature of this illness presents challenges for evaluating potential benefits. The aim of this study was to determine the feasibility of undertaking a randomised controlled trial of LCn-3PUFA supplementation in adults with COPD. Methods: A 16-week parallel, double-blind, randomised, placebo-controlled dietary supplementation trial was conducted...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29208757/critical-velocity-determined-by-a-non-exhaustive-method-in-subjects-with-copd
#4
Marceli Rocha Leite, Juliana Souza Uzeloto, Bruna Spolador de Alencar Silva, Ana Paula Coelho Figueira Freire, Fabiano Francisco de Lima, Eduardo Zapaterra Campos, Diego Giulliano Destro Christofaro, Carlos Augusto Kalva-Filho, Dionei Ramos, Ercy Mara Cipulo Ramos
BACKGROUND: Exercise training is an effective and low-cost tool for COPD rehabilitation. Thus, validating a non-exhaustive method to determine a patient's anaerobic threshold would be a very interesting tool in practical settings. We aimed to test the reproducibility of critical velocity values determined in a non-exhaustive manner (CVNE) and tolerance for exercise performed at this physiological marker in subjects with COPD. METHODS: Twelve subjects with COPD were evaluated in this cross-sectional study...
December 5, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29206641/comparison-of-exercise-training-responses-in-copd-patients-with-and-without-alpha-1-antitrypsin-deficiency
#5
Inga Jarosch, Wolfgang Hitzl, Andreas Rembert Koczulla, Marion Wencker, Tobias Welte, Rainer Gloeckl, Sabina Janciauskiene, Klaus Kenn
BACKGROUND: The benefits of pulmonary rehabilitation (PR) on fatigue-resistant skeletal muscle fibre type I have been found to be smaller in COPD patients with alpha-1 antitrypsin deficiency (AATD) than in those without AATD. Alpha-1 antitrypsin (AAT) augmentation therapy was suggested as a potential factor of influence. Whether this finding mirrors different improvements in 6-min walk distance (6MWD) between both groups remains unknown. METHODS: 140 patients with AATD-related COPD (phenotype PiZZ, FEV1: 31 ± 8%pred...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29206627/promoting-physical-activity-in-copd-insights-from-a-randomized-trial-of-a-web-based-intervention-and-pedometer-use
#6
Emily S Wan, Ana Kantorowski, Diana Homsy, Merilee Teylan, Reema Kadri, Caroline R Richardson, David R Gagnon, Eric Garshick, Marilyn L Moy
RATIONALE: Low physical activity is highly prevalent among COPD patients and is associated with increased healthcare utilization and mortality and reduced HRQL. The addition of a website to pedometer use is effective at increasing physical activity; however, the timeline of change and impact of environmental factors on efficacy is unknown. METHODS: U.S. Veterans with COPD were randomized (1:1) to receive either (1) a pedometer and website which provided goal-setting, feedback, disease-specific education, and an online community forum or (2) pedometer alone for 3 months...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29204434/a-qualitative-study-of-patients-experiences-of-participating-in-space-for-copd-a-self-management-programme-of-activity-coping-and-education
#7
Lindsay D Apps, Samantha L Harrison, Katy E Mitchell, Johanna E A Williams, Nicky Hudson, Sally J Singh
The aim of this study was to understand experiences of participation in a supported self-management programme for chronic obstructive pulmonary disease (COPD). There is a wealth of clinical trials examining the outcomes of self-management interventions for individuals with COPD, but current understanding regarding patients' perspectives of such complex interventions is limited. Further insight may help to tailor self-management interventions and maximise patient engagement. Semi-structured interviews were conducted with individuals participating in a self-management programme, SPACE for COPD...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29203713/therapeutic-potential-of-heat-shock-protein-induction-for-muscular-dystrophy-and-other-muscle-wasting-conditions
#8
REVIEW
Savant S Thakur, Kristy Swiderski, James G Ryall, Gordon S Lynch
Duchenne muscular dystrophy is the most common and severe of the muscular dystrophies, a group of inherited myopathies caused by different genetic mutations leading to aberrant expression or complete absence of cytoskeletal proteins. Dystrophic muscles are prone to injury, and regenerate poorly after damage. Remorseless cycles of muscle fibre breakdown and incomplete repair lead to progressive and severe muscle wasting, weakness and premature death. Many other conditions are similarly characterized by muscle wasting, including sarcopenia, cancer cachexia, sepsis, denervation, burns, and chronic obstructive pulmonary disease...
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29194864/comparison-of-outpatient-and-home-based-exercise-training-programmes-for-copd-a-systematic-review-and-meta-analysis
#9
REVIEW
Francesca Wuytack, Declan Devane, Elizabeth Stovold, Melissa McDonnell, Michelle Casey, Timothy J McDonnell, Paddy Gillespie, Adam Raymakers, Yves Lacasse, Bernard McCarthy
Chronic obstructive pulmonary disease is a common, preventable and treatable disease. Exercise training programmes (ETPs) improve symptoms, health-related quality of life (HRQoL) and exercise capacity, but the optimal setting is unknown. In this review, we compared the effects of ETPs in different settings on HRQoL and exercise capacity. We searched (5 July 2016) the Cochrane Airways Group Specialised Register, ClinicalTrials.gov and World Health Organization trials portal. We selected studies, extracted data and assessed risk of bias with two independent reviewers...
November 30, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29191775/agreement-of-different-reference-equations-to-classify-patients-with-copd-as-having-reduced-or-preserved-6mwd
#10
F V C Machado, G W Bisca, A A Morita, A Rodrigues, V S Probst, K C Furlanetto, F Pitta, N A Hernandes
BACKGROUND: Interpretation of the six-minute walk distance (6MWD) is enhanced by using recommended reference equations. Whenever possible, the choice of equation should be region-specific. A potential problem is that different equations for the 6MWD may have been developed for the same population, and it may be complicated to choose the most suitable. OBJECTIVE: To verify the agreement of different reference equations in classifying patients with Chronic Obstructive Pulmonary Disease (COPD) as having reduced or preserved 6MWD...
November 27, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29184398/the-role-of-pain-in-pulmonary-rehabilitation-a-qualitative-study
#11
Samantha L Harrison, Annemarie L Lee, Helene L Elliott-Button, Rebecca Shea, Roger S Goldstein, Dina Brooks, Cormac G Ryan, Denis J Martin
Introduction: One third of individuals with chronic obstructive pulmonary disease (COPD) report pain. To help inform a COPD-specific pain intervention, we explored the views of health care providers (HCPs) and individuals with COPD on pain during pulmonary rehabilitation (PR). Methods: This is a qualitative study using inductive thematic analysis. Eighteen HCPs familiar with PR and 19 patients enrolled in PR participated in semi-structured interviews. Demographic data were recorded, and the patients completed the Brief Pain Inventory (Short Form)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29180861/healthy-lifestyle-behaviors-among-individuals-with-chronic-obstructive-pulmonary-disease-in-urban-and-rural-communities-in-china-a-large-community-based-epidemiological-study
#12
Ruohua Yan, Yang Wang, Jian Bo, Wei Li
Background: Lifestyle modification is one of the most cost-effective strategies in self-management and secondary prevention of chronic obstructive pulmonary disease (COPD). However, the prevalence of healthy lifestyle behaviors in COPD patients in China remains unclear. The objective of this study was to examine the rates of healthy lifestyle behaviors including smoking cessation, regular exercise, and healthy diet in community population with COPD in China. Methods: We recruited 46,285 individuals aged 35-70 years from 115 urban and rural communities in 12 provinces of China from 2005 to 2009...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29169250/clinical-effects-of-cognitive-impairment-in-patients-with-chronic-obstructive-pulmonary-disease
#13
Esra Ertan Yazar, Senay Aydin, Gulsah Gunluoglu, Sadettin Kamat, Adil Can Gungen, Pinar Yildiz
The aim of this study was to evaluate the clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease (COPD). A total of 91 patients with stable moderate to very severe COPD were included in this study. Cognitive functions of the patients were evaluated using the mini-mental state examination (MMSE) tool and clock-drawing test. The Brody's Instrumental Activities of Daily Living (IADL) Questionnaire; COPD assessment test (CAT); body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE); and Charlson comorbidity index were assessed...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29162719/limiting-factors-in-walking-performance-of-subjects-with-copd
#14
Marcela Alves Sanseverino, Matteo Pecchiari, Renata Luisa Bona, Danilo Cortozi Berton, Francisco Busolli de Queiroz, Mathieu Gruet, Leonardo A Peyré-Tartaruga
INTRODUCTION: Exercise intolerance is the most predominant symptom in patients with COPD. Nevertheless, it is unclear whether walking economy and gait variability are altered in these patients. Thus, our main objective was to compare the cost of transport and gait variability as a function of speed, including the self-selected walking speed, in subjects with COPD relative to healthy subjects. METHODS: 22 subjects, 11 with COPD (FEV1 = 45 ± 17% of predicted) and 11 age- and sex-matched healthy subjects undertook an evaluation that involved walking on a treadmill at 6 speeds (at 3...
November 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29160737/community-singing-groups-for-people-with-chronic-obstructive-pulmonary-disease-participant-perspectives
#15
Ann Skingley, Stephen Clift, Sadie Hurley, Sonia Price, Lizzi Stephens
AIM: Chronic obstructive pulmonary disease (COPD) is a major public health issue which is irreversible and progressive, but previous research suggests that singing may have beneficial effects. The aim of this study was to establish the views of participants with COPD taking part in a singing for better breathing programme. METHODS: This was a descriptive qualitative study nested within a single-cohort feasibility study which included measures of lung function and wellbeing...
November 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/29158671/correlation-and-compatibility-between-surface-respiratory-electromyography-and-transesophageal-diaphragmatic-electromyography-measurements-during-treadmill-exercise-in-stable-patients-with-copd
#16
Weiliang Wu, Lili Guan, Xiaoying Li, Lin Lin, Bingpeng Guo, Yuqiong Yang, Zhenyu Liang, Fengyan Wang, Luqian Zhou, Rongchang Chen
Purpose: To evaluate the compatibility and correlation between noninvasive surface respiratory electromyography and invasive transesophageal diaphragmatic electromyography measurements as facilitating indicators of neural respiratory drive (NRD) evaluation during treadmill exercise. Patients and methods: Transesophageal diaphragmatic electromyogram activity (EMGdi,es) and surface inspiratory electromyogram (EMG) activity, including surface diaphragmatic EMG activity (EMGdi,sur), surface parasternal intercostal muscle EMG activity (EMGpara), and surface sternocleidomastoid EMG activity (EMGsc), were detected simultaneously during increasing exercise capacity in 20 stable patients with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29158206/pulmonary-rehabilitation-with-balance-training-for-fall-reduction-in-chronic-obstructive-pulmonary-disease-protocol-for-a-randomized-controlled-trial
#17
Marla K Beauchamp, Dina Brooks, Cindy Ellerton, Annemarie Lee, Jennifer Alison, Pat G Camp, Gail Dechman, Kimberley Haines, Samantha L Harrison, Anne E Holland, Alda Marques, Rahim Moineddin, Elizabeth H Skinner, Lissa Spencer, Michael K Stickland, Feng Xie, Roger S Goldstein
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. A growing body of evidence shows that individuals with COPD have important deficits in balance control that may be associated with an increased risk of falls. Pulmonary rehabilitation (PR) is a key therapeutic intervention for individuals with COPD; however, current international guidelines do not include balance training and fall prevention strategies. OBJECTIVE: The primary aim of this trial is to determine the effects of PR with balance training compared to PR with no balance training on the 12-month rate of falls in individuals with COPD...
November 20, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29146301/association-of-sputum-and-blood-eosinophil-concentrations-with-clinical-measures-of-copd-severity-an-analysis-of-the-spiromics-cohort
#18
Annette T Hastie, Fernando J Martinez, Jeffrey L Curtis, Claire M Doerschuk, Nadia N Hansel, Stephanie Christenson, Nirupama Putcha, Victor E Ortega, Xingnan Li, R Graham Barr, Elizabeth E Carretta, David J Couper, Christopher B Cooper, Eric A Hoffman, Richard E Kanner, Eric Kleerup, Wanda K O'Neal, Richard Paine, Stephen P Peters, Neil E Alexis, Prescott G Woodruff, MeiLan K Han, Deborah A Meyers, Eugene R Bleecker
BACKGROUND: Increased concentrations of eosinophils in blood and sputum in chronic obstructive pulmonary disease (COPD) have been associated with increased frequency of exacerbations, reduced lung function, and corticosteroid responsiveness. We aimed to assess whether high eosinophil concentrations in either sputum or blood are associated with a severe COPD phenotype, including greater exacerbation frequency, and whether blood eosinophils are predictive of sputum eosinophils. METHODS: We did a multicentre observational study analysing comprehensive baseline data from SPIROMICS in patients with COPD aged 40-80 years who had a smoking history of at least 20 pack-years, recruited from six clinical sites and additional subsites in the USA between Nov 12, 2010, and April 21, 2015...
November 13, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29144103/effects-of-home-based-superimposed-neuromuscular-electrical-stimulation-in-severe-chronic-obstructive-pulmonary-disease-patients-a-randomized-controlled-clinical-trial
#19
Marie C Valenza, Irene Torres-Sánchez, Laura López-López, Irene Cabrera-Martos, Araceli Ortiz-Rubio, Gerald Valenza-Demet
BACKGROUND: COPD patients experience a sustained deterioration of several capacities. Those with severe COPD undergo a considerable decline in their physical and functional capacities, but pulmonary rehabilitation (PR) is used to reduce the weakness of such patients. To date, neuromuscular electrical stimulation (NMES) has been used in acute COPD patients but NMES superimposed onto voluntary muscular contraction has not been tested in COPD patients. AIM: The aim of this study was to evaluate the effects of superimposed NMES on the cardiorespiratory performance and functionality of severe COPD patients undergoing a home-based rehabilitation program...
November 16, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29138547/efficacy-of-tiotropium-and-indacaterol-monotherapy-and-their-combination-on-dynamic-lung-hyperinflation-in-copd-a-random-open-label-crossover-study
#20
Keisaku Fujimoto, Haruna Yamazaki, Midori Ura, Yoshiaki Kitaguchi
Background and objective: The difference in efficacy of long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) for dynamic lung hyperinflation (DLH) in COPD is unclear. The purpose of this study was to elucidate the difference in efficacy of LAMA and LABA alone and the combination thereof for DLH. Subjects and methods: Thirty stable patients were enrolled and randomly divided into two groups following baseline measurements. One group was treated with 5 μg tiotropium (Respimat inhaler) for 4 weeks following a 4-week treatment with 150 μg indacaterol, while the other group was treated with indacaterol for 4 weeks following a 4-week treatment with tiotropium...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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