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Alternate day fasting

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https://www.readbyqxmd.com/read/27915207/fixed-distance-walk-tests-at-comfortable-and-fast-speed-potential-tools-for-the-functional-assessment-of-coronary-patients
#1
Marie-Doriane Morard, Delphine Besson, Davy Laroche, Alexandre Naaïm, Vincent Gremeaux, Jean-Marie Casillas
OBJECTIVES: There is ambiguity concerning the walk tests available for functional assessment of coronary patients, particularly for the walking speed. This study explores the psychometric properties of two walking tests, based on fixed-distance tests, at comfortable and fast velocity, in stabilized patients at the end of a cardiac rehabilitation program. METHODS: At a three-day interval 58 coronary patients (mean age of 64.85±6.03 years, 50 men) performed three walk tests, the first two at a comfortable speed in a random order (6-minute walk test - 6MWT - and 400-metre comfortable walk test - 400mCWT) and the third at a brisk speed (200-metre fast walk test - 200mFWT)...
November 30, 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27907006/prediction-of-impending-type-1-diabetes-through-automated-dual-label-measurement-of-proinsulin-c-peptide-ratio
#2
Annelien Van Dalem, Simke Demeester, Eric V Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K Gorus
BACKGROUND: The hyperglycemic clamp test, the gold standard of beta cell function, predicts impending type 1 diabetes in islet autoantibody-positive individuals, but the latter may benefit from less invasive function tests such as the proinsulin:C-peptide ratio (PI:C). The present study aims to optimize precision of PI:C measurements by automating a dual-label trefoil-type time-resolved fluorescence immunoassay (TT-TRFIA), and to compare its diagnostic performance for predicting type 1 diabetes with that of clamp-derived C-peptide release...
2016: PloS One
https://www.readbyqxmd.com/read/27903733/development-of-activity-in-the-mouse-visual-cortex
#3
Jing Shen, Matthew T Colonnese
: A comprehensive developmental timeline of activity in the mouse cortex in vivo is lacking. Understanding the activity changes that accompany synapse and circuit formation is important to understand the mechanisms by which activity molds circuits and would help to identify critical checkpoints for normal development. To identify key principles of cortical activity maturation, we systematically tracked spontaneous and sensory-evoked activity with extracellular recordings of primary visual cortex (V1) in nonanesthetized mice...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27899768/effects-of-dietary-restriction-on-adipose-mass-and-biomarkers-of-healthy-aging-in-human
#4
Daniele Lettieri-Barbato, Esmeralda Giovannetti, Katia Aquilano
In developing countries the rise of obesity and obesity-related metabolic disorders, such as cardiovascular diseases and type 2 diabetes, reflects the changes in lifestyle habits and wrong dietary choices. Dietary restriction (DR) regimens have been shown to extend health span and lifespan in many animal models including primates. Identifying biomarkers predictive of clinical benefits of treatment is one of the primary goals of precision medicine. To monitor the clinical outcomes of DR interventions in humans, several biomarkers are commonly adopted...
November 29, 2016: Aging
https://www.readbyqxmd.com/read/27899238/goat-umbilical-cord-cells-are-permissive-to-small-ruminant-lentivirus-infection-in-vitro
#5
Gabrielle R Martins, Rebeca C Marinho, Rosivaldo Q Bezerra Junior, Antoniel de O Alves, Lilia M C Câmara, Luiz C Albuquerque-Pinto, Maria F da S Teixeira
Small ruminant lentiviruses isolated from peripheral blood leukocytes and target organs can be propagated in vitro in fibroblasts derived from goat synovial membrane cells. These cells are obtained from tissues collected from embryos or fetuses and are necessary for the establishment of the fibroblast primary culture. A new alternative type of host cells, derived from goat umbilical cord, was isolated and characterized phenotypically with its main purpose being to obtain cell monolayers that could be used for the diagnosis and isolation of small ruminant lentiviruses in cell culture...
November 19, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27889163/differential-detection-of-pathogenic-yersinia-spp-by-fluorescence-in-situ-hybridization
#6
Alexander Rohde, Jens Andre Hammerl, Bernd Appel, Ralf Dieckmann, Sascha Al Dahouk
Yersinia enterocolitica, Y. pseudotuberculosis and Y. pestis are pathogens of major medical importance, which are responsible for a considerable number of infections every year. The detection of these species still relies on cultural methods, which are slow, labour intensive and often hampered by the presence of high amounts of accompanying flora. In this study, fluorescence in situ hybridization (FISH) was used to develop a fast, sensitive and reliable alternative to detect viable bacteria in food. For this purpose, highly specific probes targeting the 16S and 23S ribosomal RNA were employed to differentially detect each of the three species...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27888990/a-randomized-controlled-multicentric-study-of-inhaled-budesonide-and-intravenous-methylprednisolone-in-the-treatment-on-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#7
Zhen Ding, Xiu Li, Youjin Lu, Guangsheng Rong, Ruiqing Yang, Ruixia Zhang, Guiqin Wang, Xiqiang Wei, Yongqing Ye, Zhaoxia Qian, Hongyan Liu, Daifeng Zhu, Ruiqing Zhou, Kun Zhu, Rongping Ni, Kui Xia, Nan Luo, Cong Pei
BACKGROUND: Almost all international guidelines recommend corticosteroids for management of exacerbations of chronic obstructive pulmonary disease (COPD), because it leads to improved outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Nevertheless, due to its side effects, there are still concerns regarding the use of systemic corticosteroid (SC). Inhaled corticosteroids (IC) can be used as an alternative to SC, while reducing the risk of occurrence of side effects...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27881895/state-dependent-behavior-and-alternative-behavioral-strategies-in-brown-trout-salmo-trutta-l-fry
#8
Joacim Näslund, Jörgen I Johnsson
ABSTRACT: Animals generally adjust their behavior in response to bodily state (e.g., size and energy reserves) to optimize energy intake in relation to mortality risk, weighing predation probability against the risk of starvation. Here, we investigated whether brown trout Salmo trutta adjust their behavior in relation to energetic status and body size during a major early-life selection bottleneck, when fast growth is important. Over two consecutive time periods (P1 and P2; 12 and 23 days, respectively), food availability was manipulated, using four different combinations of high (H) and low (L) rations (i...
2016: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/27881670/the-effect-of-alternate-day-caloric-restriction-on-the-metabolic-consequences-of-eight-days-bed-rest-in-healthy-lean-men-a-randomized-trial
#9
Nina Majlund Harder-Lauridsen, Signe Tellerup Nielsen, Sebastian Porsdam Mann, Mark Preben Lyngbæk, Fabiana Braga Benatti, Annika Reynberg Langkilde, Ian Law, Anne-Sophie Wedell-Neergaard, Carsten Thomsen, Kirsten Moller, Kristian Karstoft, Bente Klarlund Pedersen, Rikke Krogh-Madsen
BACKGROUND: Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment, by overlapping mechanisms. OBJECTIVE: To test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after eight consecutive days in bed...
November 23, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27845908/endoscopic-versus-laparoscopic-resection-of-gastric-gastrointestinal-stromal-tumors-a-multicenter-study
#10
Wei-Jie Dai, Gao Liu, Min Wang, Wen-Jie Liu, Wei Song, Xiao-Zhong Yang, Qi-Long Wang, Xiao-Yu Zhang, Zhi-Ning Fan
Despite endoscopic resection has been performed to treat gastric gastrointestinal stromal tumor (GISTs). However, the safety and long-term outcomes remains controversial. This study aims to compare the safety and surgical outcomes of endoscopic versus laparoscopic resection of gastric GISTs. A total of 335 patients that were pathologically confirmed with gastric GISTs (tumor size ≤ 3.5 cm) were surgically treated with endoscopic resection (endoscopic group) or laparoscopic resection (laparoscopic group) in three institutions from March 1, 2011 to October 1 2014...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27843856/induced-sputum-versus-bronchial-washings-in-the-diagnosis-of-sputum-negative-pulmonary-tuberculosis
#11
Gopathi Nageswar Rao, Mandava Venu, Namballa Usha Rani, Makala Sravani
INTRODUCTION: Tuberculosis (TB) is one of the most important public health problems worldwide. Detecting patients with active pulmonary TB (PT) is an important component of TB control programs. However, at times in patients even with a compatible clinical picture, sputum smears do not reveal acid-fast bacilli (AFB) and smear-negative PT remains a common problem. This study compares the results of induced sputum (IS) and bronchial washings (BWs) in detecting sputum negative PT. MATERIALS AND METHODS: A prospective study conducted from June 2014 to June 2015, comprising 120 patients fulfilling study criteria...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27832095/increased-muscular-5%C3%AE-dihydrotestosterone-in-response-to-resistance-training-relates-to-skeletal-muscle-mass-and-glucose-metabolism-in-type-2-diabetic-rats
#12
Naoki Horii, Koji Sato, Noboru Mesaki, Motoyuki Iemitsu
Regular resistance exercise induces skeletal muscle hypertrophy and improvement of glycemic control in type 2 diabetes patients. Administration of dehydroepiandrosterone (DHEA), a sex steroid hormone precursor, increases 5α-dihydrotestosterone (DHT) synthesis and is associated with improvements in fasting blood glucose level and skeletal muscle hypertrophy. Therefore, the aim of this study was to investigate whether increase in muscle DHT levels, induced by chronic resistance exercise, can contribute to skeletal muscle hypertrophy and concomitant improvement of muscular glucose metabolism in type 2 diabetic rats...
2016: PloS One
https://www.readbyqxmd.com/read/27798346/maternal-circadian-eating-time-and-frequency-are-associated-with-blood-glucose-concentrations-during-pregnancy
#13
See Ling Loy, Jerry Kok Yen Chan, Poh Hui Wee, Marjorelee T Colega, Yin Bun Cheung, Keith M Godfrey, Kenneth Kwek, Seang Mei Saw, Yap-Seng Chong, Padmapriya Natarajan, Falk Müller-Riemenschneider, Ngee Lek, Mary Foong-Fong Chong, Fabian Yap
BACKGROUND: Synchronizing eating schedules to daily circadian rhythms may improve metabolic health, but its association with gestational glycemia is unknown. OBJECTIVE: This study examined the association of maternal night-fasting intervals and eating episodes with blood glucose concentrations during pregnancy. METHODS: This was a cross-sectional study within a prospective cohort in Singapore. Maternal 24-h dietary recalls, fasting glucose, and 2-h glucose concentrations were ascertained at 26-28 wk gestation for 1061 women (aged 30...
October 19, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27789327/chronic-administration-of-ethanol-leaf-extract-of-moringa-oleifera-lam-moringaceae-may-compromise-glycaemic-efficacy-of-sitagliptin-with-no-significant-effect-in-retinopathy-in-a-diabetic-rat-model
#14
Comfort Olurishe, Helen Kwanashie, Abdulkadiri Zezi, Nuhu Danjuma, Bisalla Mohammed
ETHNOPHARMACOLOGICAL RELEVANCE: Moringa oleifera Lam. (Moringaceae) has gained awareness for its antidiabetic effect, and is used as alternative therapy or concurrently with orthodox medicines such as sitagliptin in diabetes mellitus. This is without ascertaining the possibility of drug-herb interactions, which could either lead to enhanced antidiabetic efficacy, increased toxicity, or compromised glycaemic control with negative consequence in diabetic retinopathy. AIM OF THE STUDY: To investigate the effect, of sitagliptin (50mg/kg), Moringa oleifera (300mg/kg) leaf extract, and a combination of both on glycaemic control parameters, lenticular opacity and changes in retinal microvasculature in alloxan (150mg/kg i...
October 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27768278/electrospun-photochromic-hybrid-membranes-for-flexible-rewritable-media
#15
Jing Wei, Xiuling Jiao, Ting Wang, Dairong Chen
Ink-free rewritable media has attracted great attention as a potential alternative to current paper prints, owing to its benefits to reducing paper production and consumption for environmental protection. It is desirable to develop rewritable media based on cheap, robust, and fast-response photochromic systems. Herein, we report the design and fabrication of flexible and photorewritable PVP/a-WO3 hybrid membranes through electrospinning, on which images with high resolution can be photoprinted and heat-erased for over 40 cycles...
October 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27757829/effect-of-probiotic-soy-milk-on-serum-levels-of-adiponectin-inflammatory-mediators-lipid-profile-and-fasting-blood-glucose-among-patients-with-type-ii-diabetes-mellitus
#16
Sadegh Feizollahzadeh, Reza Ghiasvand, Abbas Rezaei, Hossein Khanahmad, Akram Sadeghi, Mitra Hariri
Probiotic therapies are going to be an effective alternative therapeutic strategy in the treatment and management of diabetes. The mechanism behind the essential effects of probiotic therapies in diabetic patients was not fully understood. The objective of this study was to evaluate the effects of probiotic soy milk containing Lactobacillus planetarum A7 on inflammation, lipid profile, fasting blood glucose, and serum adiponectin among patients with type 2 diabetes mellitus. Forty patients with type 2 diabetes, at the age of 35-68 years old, were assigned to two groups in this randomized, double-blind, controlled clinical trial...
October 18, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27747530/pharmacokinetics-and-bioequivalence-study-of-hydroxychloroquine-sulfate-tablets-in-chinese-healthy-volunteers-by-lc-ms-ms
#17
Hong-Wei Fan, Zhi-Xiang Ma, Jing Chen, Xing-Ye Yang, Jun-Lin Cheng, Ying-Bin Li
INTRODUCTION: Hydroxychloroquine (HCQ), 4-aminoquinoline, is an antimalarial drug and has become a basic therapy for rheumatic disease treatment. It can stabilize the condition of SLE patients and reduce the chances of patient relapse through its immunosuppressive function and antiinflammatory effects. This drug was absorbed completely and rapidly by oral administration, but has a prolonged half-life for elimination. The objective of this study was to evaluate the pharmacokinetic parameters and relative bioequivalence of a new generic (test) formulation with the branded (reference) formulation of HCQ in healthy Chinese male volunteers...
December 2015: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27746068/targeting-postprandial-blood-sugar-over-fasting-blood-sugar-a-clinic-based-comparative-study
#18
H M M Herath, T P Weerarathna, C L Fonseka, A S Vidanagamage
INTRODUCTION: Recent studies indicate that modulation of post prandial blood sugar (PPBS) plays an important role in the long term glycemic control. Measurement of PPBS is more convenient for patients attending outpatient clinics than fasting blood sugar (FBS) as the former needs only two hours of fasting from the last meal. OBJECTIVE: To assess the value of PPBS monitoring in optimization of long term glycemic control among diabetic patients attending an outpatient clinic...
October 5, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27738058/cryoablation-of-atrioventricular-nodal-re-entrant-tachycardia-7-year-follow-up-in-515-patients-confirmed-safety-but-very-late-recurrences-occur
#19
Per Insulander, Hamid Bastani, Frieder Braunschweig, Nikola Drca, Göran Kennebäck, Jonas Schwieler, Jari Tapanainen, Mats Jensen-Urstad
AIMS: Cryoablation is an alternative method to radiofrequency ablation for treatment of atrioventricular nodal re-entrant tachycardia (AVNRT). This study investigates the long-term safety and efficacy of cryoablation in AVNRT. METHODS AND RESULTS: We studied 515 consecutive patients (317 women, mean age 50 years, range 13-89 years) undergoing a first cryoablation for AVNRT between 2003 and 2008. Ablations were performed with a 6-mm Freezor Xtra catheter. Six patients were acute failures; 494 out of 509 (97%) primarily successfully ablated patients were followed up for a mean of 7...
October 13, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27737438/assessment-of-scaffolding-properties-for-chondrogenic-differentiation-of-adipose-derived-mesenchymal-stem-cells-in-nasal-reconstruction
#20
Serban San-Marina, Ayushman Sharma, Stephen G Voss, Jeffrey R Janus, Grant S Hamilton
Importance: Nasal reconstruction in patients who are missing a significant amount of structural nasal support remains a difficult challenge. One challenge is the deficiency of cartilage left within the nose as a consequence of rhinectomy or a midline destructive disease. Historically, the standard donor source for large quantities of native cartilage has been costal cartilage. Objective: To enable the development of protocols for new mesenchymal stem cell technologies as alternative procedures with reduced donor site morbidity, risk of infection and extrusion...
October 13, 2016: JAMA Facial Plastic Surgery
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