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https://www.readbyqxmd.com/read/29045902/epidermal-growth-factor-receptor-expression-licenses-type-2-helper-t-cells-to-function-in-a-t-cell-receptor-independent-fashion
#1
Carlos M Minutti, Sebastian Drube, Natalie Blair, Christian Schwartz, Jame C McCrae, Andrew N McKenzie, Thomas Kamradt, Michal Mokry, Paul J Coffer, Maria Sibilia, Alice J Sijts, Padraic G Fallon, Rick M Maizels, Dietmar M Zaiss
Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045580/early-pitfalls-in-establishing-the-british-journal-of-anaesthesia
#2
A G McKenzie
No abstract text is available yet for this article.
October 13, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29044240/erratum-gut-microbial-metabolites-limit-the-frequency-of-autoimmune-t-cells-and-protect-against-type-1-diabetes
#3
Eliana Mariño, James L Richards, Keiran H McLeod, Dragana Stanley, Yu Anne Yap, Jacinta Knight, Craig McKenzie, Jan Kranich, Ana Carolina Oliveira, Fernando J Rossello, Balasubramanian Krishnamurthy, Christian M Nefzger, Laurence Macia, Alison Thorburn, Alan G Baxter, Grant Morahan, Lee H Wong, Jose M Polo, Robert J Moore, Trevor J Lockett, Julie M Clarke, David L Topping, Leonard C Harrison, Charles R Mackay
This corrects the article DOI: 10.1038/ni.3713.
October 18, 2017: Nature Immunology
https://www.readbyqxmd.com/read/29039183/electrochemically-generated-cis-carboxylato-coordinated-iron-iv-oxo-acid-base-congeners-as-promiscuous-oxidants-of-water-pollutants
#4
David P de Sousa, Christopher J Miller, Yingyue Chang, T David Waite, Christine J McKenzie
The nonheme iron(IV) oxo complex [Fe(IV)(O)(tpenaH)](2+) and its conjugate base [Fe(IV)(O)(tpena)](+) [tpena(-) = N,N,N'-tris(2-pyridylmethyl)ethylenediamine-N'-acetate] have been prepared electrochemically in water by bulk electrolysis of solutions prepared from [Fe(III)2(μ-O)(tpenaH)2](ClO4)4 at potentials over 1.3 V (vs NHE) using inexpensive and commercially available carbon-based electrodes. Once generated, these iron(IV) oxo complexes persist at room temperature for minutes to half an hour over a wide range of pH values...
October 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29035306/platelet-endothelial-cell-adhesion-molecule-1-and-oligodendrogenesis-significance-in-alcohol-use-disorders
#5
REVIEW
Chitra D Mandyam, Emmanuel G Villalpando, Noah L Steiner, Leon W Quach, McKenzie J Fannon, Sucharita S Somkuwar
Alcoholism is a chronic relapsing disorder with few therapeutic strategies that address the core pathophysiology. Brain tissue loss and oxidative damage are key components of alcoholism, such that reversal of these phenomena may help break the addictive cycle in alcohol use disorder (AUD). The current review focuses on platelet endothelial cell adhesion molecule 1 (PECAM-1), a key modulator of the cerebral endothelial integrity and neuroinflammation, and a targetable transmembrane protein whose interaction within AUD has not been well explored...
October 16, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29028828/ised-constructing-a-high-resolution-elevation-road-dataset-from-massive-low-quality-in-situ-observations-derived-from-geosocial-fitness-tracking-data
#6
Grant McKenzie, Krzysztof Janowicz
Gaining access to inexpensive, high-resolution, up-to-date, three-dimensional road network data is a top priority beyond research, as such data would fuel applications in industry, governments, and the broader public alike. Road network data are openly available via user-generated content such as OpenStreetMap (OSM) but lack the resolution required for many tasks, e.g., emergency management. More importantly, however, few publicly available data offer information on elevation and slope. For most parts of the world, up-to-date digital elevation products with a resolution of less than 10 meters are a distant dream and, if available, those datasets have to be matched to the road network through an error-prone process...
2017: PloS One
https://www.readbyqxmd.com/read/29024669/pyramidal-cell-interneuron-circuit-architecture-and-dynamics-in-hippocampal-networks
#7
Daniel Fine English, Sam McKenzie, Talfan Evans, Kanghwan Kim, Euisik Yoon, György Buzsáki
Excitatory control of inhibitory neurons is poorly understood due to the difficulty of studying synaptic connectivity in vivo. We inferred such connectivity through analysis of spike timing and validated this inference using juxtacellular and optogenetic control of presynaptic spikes in behaving mice. We observed that neighboring CA1 neurons had stronger connections and that superficial pyramidal cells projected more to deep interneurons. Connection probability and strength were skewed, with a minority of highly connected hubs...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29024455/the-science-of-salt-a-regularly-updated-systematic-review-of-the-implementation-of-salt-reduction-interventions-september-2016-february-2017
#8
Claire Johnson, Joseph A Santos, Briar McKenzie, Sudhir Raj Thout, Kathy Trieu, Rachael McLean, Kristina S Petersen, Norm R C Campbell, Jacqui Webster
This periodic review aims to identify, summarize, and appraise studies relating to the implementation of salt reduction strategies that were published between September 2016 and February 2017. A total of 41 studies were included as relevant to the design, assessment, and implementation of salt reduction strategies, and a detailed appraisal was conducted on the seven studies that evaluated the impact of salt reduction strategies. Of these, three were national studies or included large populations and four were conducted in communities with small participant sample sizes...
October 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29024199/critical-care-pharmacy-workforce-uk-deployment-and-characteristics-in-2015
#9
Mark Borthwick, Greg Barton, Richard S Bourne, Catherine McKenzie
OBJECTIVE: Clinical pharmacists reduce medication errors and optimize the use of medication in critically ill patients, although actual staffing level and deployment of UK pharmacists is unknown. The primary aim was to investigate the UK deployment of the clinical pharmacy workforce in critical care and compare this with published standards. METHODS: An electronic data entry tool was created and distributed for UK critical care pharmacy services to record their critical care workforce deployment data...
October 11, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29024089/macronutrient-intake-of-dogs-self-selecting-diets-varying-in-composition-offered-ad-libitum
#10
M T Roberts, E N Bermingham, N J Cave, W Young, C M McKenzie, D G Thomas
The diet of the domestic dog has changed significantly from that of its wolf ancestor, with to date only two studies having examined macronutrient self-selection in dogs. Whilst the first focused solely on protein intake, determining an intake of 30% metabolisable energy (ME), the second investigated dietary protein, fat and carbohydrate (PFC), indicating an intake ratio of 30:63:7% by energy. This study's aim was to further elucidate macronutrient intake by providing greater macronutrient range, energy content, and to investigate over a longer duration than previous studies...
October 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29020619/remarkable-stability-of-myelinating-oligodendrocytes-in-mice
#11
Richa B Tripathi, Martyna Jackiewicz, Ian A McKenzie, Eleni Kougioumtzidou, Matthew Grist, William D Richardson
New myelin-forming oligodendrocytes (OLs) are generated in the mouse central nervous system during adulthood. These adult-born OLs might augment the existing population, contributing to neural plasticity, or else replace OLs that die in use (turnover). To distinguish between these alternatives, we induced genetic labeling of mature myelinating OLs in young adult mice and tracked their subsequent survival. OL survival rates were region dependent, being higher in corpus callosum (∼90% survival over 20 months) and motor cortex (∼70% survival) than in corticospinal tract or optic nerve (50%-60% survival)...
October 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/29019651/combining-machine-learning-and-nanofluidic-technology-to-diagnose-pancreatic-cancer-using-exosomes
#12
Jina Ko, Neha Bhagwat, Stephanie S Yee, Natalia Ortiz, Amine Sahmoud, Taylor Black, Nicole M Aiello, Lydie McKenzie, Mark O'Hara, Colleen Redlinger, Janae Romeo, Erica L Carpenter, Ben Z Stanger, David Issadore
Circulating exosomes contain a wealth of proteomic and genetic information, presenting an enormous opportunity in cancer diagnostics. While microfluidic approaches have been used to successfully isolate cells from complex samples, scaling these approaches for exosome isolation has been limited by the low throughput and susceptibility to clogging of nanofluidics. Moreover, the analysis of exosomal biomarkers is confounded by substantial heterogeneity between patients and within a tumor itself. To address these challenges, we developed a multi-channel nanofluidic system to analyze crude clinical samples...
October 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/29017589/randomized-trial-of-telephone-versus-in-person-delivery-of-a-brief-psychosocial-intervention-in-post-stroke-depression
#13
Catherine J Kirkness, Kevin C Cain, Kyra J Becker, David L Tirschwell, Ann M Buzaitis, Pamela L Weisman, Sylvia McKenzie, Linda Teri, Ruth Kohen, Richard C Veith, Pamela H Mitchell
BACKGROUND: A psychosocial behavioral intervention delivered in-person by advanced practice nurses has been shown effective in substantially reducing post-stroke depression (PSD). This follow-up trial compared the effectiveness of a shortened intervention delivered by either telephone or in-person to usual care. To our knowledge, this is the first of current behavioral therapy trials to expand the protocol in a new clinical sample. 100 people with Geriatric Depression Scores ≥ 11 were randomized within 4 months of stroke to usual care (N = 28), telephone intervention (N = 37), or in-person intervention (N = 35)...
October 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29016701/modifying-alcohol-consumption-to-reduce-obesity-a-randomized-controlled-feasibility-study-of-a-complex-community-based-intervention-for-men
#14
Linda Irvine, Iain K Crombie, Kathryn B Cunningham, Brian Williams, Falko F Sniehotta, John Norrie, Ambrose J Melson, Claire Jones, Peter Rice, Peter W Slane, Marcus Achison, Andrew McKenzie, Elena D Dimova, Sheila Allan
Objectives: Being obese and drinking more than 14 units of alcohol per week places men at very high risk of developing liver disease. This study assessed the feasibility of a trial to reduce alcohol consumption. It tested the recruitment strategy, engagement with the intervention, retention and study acceptability. Methods: Men aged 35-64 years who drank >21 units of alcohol per week and had a BMI > 30 were recruited by two methods: from GP patient registers and by community outreach...
September 18, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28994464/dosimetric-consequences-of-gold-nanoparticle-clustering-during-photon-irradiation
#15
Charles Kirkby, Brandon Koger, Natalka Suchowerska, David R McKenzie
PURPOSE: The radiation dose enhancement caused by introducing gold nanoparticles (GNP) into cells can increase the dose locally absorbed. A disconnect between experimentally determined survival and dose enhancements predicted by Monte Carlo simulations on macroscopic scales, suggests small-scale energy deposition patterns play an important role in GNP dose enhancement. Clustering of the GNPs could potentially alter small scale energy deposition patterns. Here we use Monte Carlo simulations to quantify energy deposition patterns in the presence of clustered GNPs and address the question of whether clustering of the nanoparticles affects the energy deposition patterns and ultimately cellular response...
October 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28991040/associations-of-muscle-mass-and-strength-with-all-cause-mortality-among-us-older-adults
#16
Ran Li, Jin Xia, Xi Zhang, Wambui Grace Gathirua-Mwangi, Jianjun Guo, Yufeng Li, Steve McKenzie, Yiqing Song
INTRODUCTION: Recent studies suggested that muscle mass and muscle strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality in the general population are sparse. METHODS: We aimed to prospectively examine individual and joint associations of low muscle mass and low muscle strength with all-cause mortality in a nationally representative sample. This study included 4,449 participants aged 50 years and older from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 with public-use 2011 linked mortality files...
October 4, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28991038/exercise-prescription-and-adherence-for-breast-cancer-one-size-does-not-fitt-all
#17
Amy A Kirkham, Alis Bonsignore, Kelcey A Bland, Donald C McKenzie, Karen A Gelmon, Cheri L Van Patten, Kristin L Campbell
PURPOSE: To prospectively assess adherence to oncologist-referred, exercise programming consistent with current recommendations for cancer survivors among women with early breast cancer across the trajectory of adjuvant treatment. METHODS: Sixty-eight women participated in supervised, hour-long, moderate-intensity, aerobic and resistance exercise 3x/week during adjuvant chemotherapy ± radiation, with a step-down in frequency for 20 additional weeks. Adherence to exercise frequency (i...
October 5, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28990860/in-a-genomic-era-placental-pathology-still-holds-the-key-in-the-nondysmorphic-stillbirth
#18
Jamie Campbell, Kristy Armstrong, Nithiya Palaniappan, Eddy Maher, Mary Glancy, Mary Porteous, Kathryn J Mckenzie, Margaret J Evans
Objective To explore the relative utility of genetic testing in contrast to placental pathology in explaining causation of death in the structurally normal stillborn population. Methods A retrospective review of a structurally normal stillborn infant cohort in South East Scotland between 2011 and 2015, defined by death at or after 24 weeks of gestation. We reviewed pathology reports and collected demographic data on cases. This information was collated with genetic test results (quantitative fluorescent polymerase chain reaction and microarray analysis) and placental pathology to create a database for analysis...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28989994/arteriovenous-malformation-in-a-youth-with-atypical-autism-symptoms
#19
Veena Sison, Tracy Stackhouse, Robert Breeze, Terry Hall, Pamela McKenzie, Nicole Tartaglia
Cerebral arteriovenous malformations (AVMs) present a challenge to diagnose in children with developmental disability, because of the overlap in behavioral symptoms and neurologic manifestations. They have been very rarely reported in conjunction with autism spectrum disorder. This case involves a 13 year old male with a history of autism spectrum disorder and significant behavioral issues diagnosed with a thalamic AVM following lateralizing neurologic symptoms. Despite radiosurgical treatment, hemorrhage followed consequently causing extensive neurologic injury and death...
2017: J Child Dev Disord
https://www.readbyqxmd.com/read/28987342/where-and-when-adolescents-are-physically-active-neighborhood-environment-and-psychosocial-correlates-and-their-interactions
#20
L G Perez, T L Conway, E M Arredondo, J P Elder, J Kerr, T L McKenzie, J F Sallis
Female adolescents are less active than male peers in certain contexts including the neighborhood. Adolescents' physical activity can be explained by interactions between environmental and psychosocial factors, but few studies have tested such interactions in relation to context-specific behaviors. This study tested interactions between neighborhood environmental and psychosocial factors in relation to adolescents' context-specific physical activity. Data were collected in 2009-11 from 910 adolescents and a parent/guardian residing in the Baltimore/Seattle regions...
October 5, 2017: Preventive Medicine
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