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https://www.readbyqxmd.com/read/28212181/effect-of-a-high-rate-versus-a-low-rate-oxytocin-infusion-for-maintaining-uterine-contractility-during-elective-cesarean-delivery-a-prospective-randomized-clinical-trial
#1
Adrienne Duffield, Christine McKenzie, Brendan Carvalho, Bharathi Ramachandran, Victoria Yin, Yasser Y El-Sayed, Edward T Riley, Alexander J Butwick
BACKGROUND: Oxytocin is routinely used as prophylaxis against uterine atony. During elective cesarean delivery (CD), an oxytocin bolus is used to initiate adequate uterine tone, followed by an oxytocin infusion to maintain uterine contractility. However, it is unclear whether oxytocin maintenance infusion rate influences total estimated blood loss (EBL). METHODS: We performed a prospective, randomized, double-blind trial in 51 women undergoing elective CD. Women were randomly assigned to receive an oxytocin maintenance infusion of 2...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28202275/restoring-rocky-intertidal-communities-lessons-from-a-benthic-macroalgal-ecosystem-engineer
#2
REVIEW
Alecia Bellgrove, Prudence F McKenzie, Hayley Cameron, Jacqueline B Pocklington
As coastal population growth increases globally, effective waste management practices are required to protect biodiversity. Water authorities are under increasing pressure to reduce the impact of sewage effluent discharged into the coastal environment and restore disturbed ecosystems. We review the role of benthic macroalgae as ecosystem engineers and focus particularly on the temperate Australasian fucoid Hormosira banksii as a case study for rocky intertidal restoration efforts. Research focussing on the roles of ecosystem engineers is lagging behind restoration research of ecosystem engineers...
February 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28199334/childhood-hematologic-cancer-and-residential-proximity-to-oil-and-gas-development
#3
Lisa M McKenzie, William B Allshouse, Tim E Byers, Edward J Bedrick, Berrin Serdar, John L Adgate
BACKGROUND: Oil and gas development emits known hematological carcinogens, such as benzene, and increasingly occurs in residential areas. We explored whether residential proximity to oil and gas development was associated with risk for hematologic cancers using a registry-based case-control study design. METHODS: Participants were 0-24 years old, living in rural Colorado, and diagnosed with cancer between 2001-2013. For each child in our study, we calculated inverse distance weighted (IDW) oil and gas well counts within a 16...
2017: PloS One
https://www.readbyqxmd.com/read/28196956/amino-acid-catabolism-in-staphylococcus-aureus-and-the-function-of-carbon-catabolite-repression
#4
Cortney R Halsey, Shulei Lei, Jacqueline K Wax, Mckenzie K Lehman, Austin S Nuxoll, Laurey Steinke, Marat Sadykov, Robert Powers, Paul D Fey
Staphylococcus aureus must rapidly adapt to a variety of carbon and nitrogen sources during invasion of a host. Within a staphylococcal abscess, preferred carbon sources such as glucose are limiting, suggesting that S. aureus survives through the catabolism of secondary carbon sources. S. aureus encodes pathways to catabolize multiple amino acids, including those that generate pyruvate, 2-oxoglutarate, and oxaloacetate. To assess amino acid catabolism, S. aureus JE2 and mutants were grown in complete defined medium containing 18 amino acids but lacking glucose (CDM)...
February 14, 2017: MBio
https://www.readbyqxmd.com/read/28196405/psychosocial-interventions-for-supporting-women-to-stop-smoking-in-pregnancy
#5
REVIEW
Catherine Chamberlain, Alison O'Mara-Eves, Jessie Porter, Tim Coleman, Susan M Perlen, James Thomas, Joanne E McKenzie
BACKGROUND: Tobacco smoking remains one of the few preventable factors associated with complications in pregnancy, and has serious long-term implications for women and babies. Smoking in pregnancy is decreasing in high-income countries, but is strongly associated with poverty and is increasing in low- to middle-income countries. OBJECTIVES: To assess the effects of smoking cessation interventions during pregnancy on smoking behaviour and perinatal health outcomes...
February 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28194599/common-factors-in-community-mental-health-intervention-a-scoping-review
#6
Sean A Kidd, Larry Davidson, Kwame McKenzie
While there is considerable research and commentary devoted to common factors in psychotherapy, their implications for community mental health interventions are much less clear. In response, a scoping review was conducted to answer the question, 'What is the evidence base for common factors in community mental health intervention?' A comprehensive search of MEDLINE, PsycINFO, and Google Scholar was completed. A total of 60 publications were identified in this review with a focus primarily upon therapeutic alliance...
February 13, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28192649/core-polystyrene-shell-poly-glycerol-mono-methacrylate-particles
#7
Andrew McKenzie, Richard Hoskins, Thomas Swift, Colin A Grant, Stephen Rimmer
A set of water swollen core-shell particles was synthesized by polymerization of a 1,3-dioxolane-functional monomer in water using emulsion polymerization. After removal of the 1,3-dioxolane group the particles' shells were shown to swell in aqueous media. On hydrolysis the particles increased in size from around 70 nm to 100-130 nm. A bicinchoninic acid assay and zeta potential measurements were used to investigate adsorption of lysozyme, albumin or fibrinogen. Each of the core shell particles adsorbed significantly less protein than the non-coated core, polystyrene particles...
February 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28186951/incentives-and-disincentives-for-treating-of-depression-and-anxiety-in-ontario-family-health-teams-protocol-for-a-grounded-theory-study
#8
Rachelle Ashcroft, Matthew Menear, Jose Silveira, Simone Dahrouge, Kwame McKenzie
INTRODUCTION: There is strong consensus that prevention and management of common mental disorders (CMDs) should occur in primary care and evidence suggests that treatment of CMDs in these settings can be effective. New interprofessional team-based models of primary care have emerged that are intended to address problems of quality and access to mental health services, yet many people continue to struggle to access care for CMDs in these settings. Insufficient attention directed towards the incentives and disincentives that influence care for CMDs in primary care, and especially in interprofessional team-based settings, may have resulted in missed opportunities to improve care quality and control healthcare costs...
November 14, 2016: BMJ Open
https://www.readbyqxmd.com/read/28184172/practically-prepared-pre-intern-student-views-following-an-education-package
#9
Susan McKenzie, Craig Mellis
BACKGROUND: Graduating medical students enter their internship with varied levels of practical experience in procedural skills. To address this problem, many medical schools have introduced intensive skill training courses immediately prior to graduation. This study examines the impact of a pre-intern (PrInt) education package, consisting of a short intensive course, followed by a one-month clinical attachment. METHODS: In September 2014, all PrInt students (n = 53) at the Central Clinical School (Sydney, NSW, Australia) attended three days of intensive training...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28168760/models-projecting-the-fate-of-fish-populations-under-climate-change-need-to-be-based-on-valid-physiological-mechanisms
#10
Sjannie Lefevre, David J McKenzie, Göran E Nilsson
Some recent modelling papers projecting fish sizes and catches in a warmer future are based on erroneous assumptions regarding 1) the scaling of gills with body mass and 2) the energetic cost of 'maintenance'. Assumption 1) posits that insurmountable geometric constraints prevent respiratory surface areas from growing as fast as body volume. It is argued that these constraints explain allometric scaling of energy metabolism, whereby larger fish have relatively lower mass specific metabolic rates. Assumption 2) concludes that when fish reach a certain size, basal oxygen demands will not be met, because of assumption 1)...
February 6, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28167514/pediatric-exposures-to-veterinary-pharmaceuticals
#11
Suzanne Tomasi, Kristin J Roberts, Jason Stull, Henry A Spiller, Lara B McKenzie
OBJECTIVE: To describe the epidemiology of veterinary pharmaceutical-related exposures to children based on calls to a regional poison control center. METHODS: A retrospective analysis of pediatric (≤19 years of age) exposures to pharmaceutical products intended for animal use, managed by a regional poison control center from 1999 through 2013, was conducted. Case narratives were reviewed and coded for exposure-related circumstances and intended species. Descriptive statistics were generated...
February 6, 2017: Pediatrics
https://www.readbyqxmd.com/read/28167503/ubiquitylation-activates-a-peptidase-that-promotes-cleavage-and-destabilization-of-its-activating-e3-ligases-and-diverse-growth-regulatory-proteins-to-limit-cell-proliferation-in-arabidopsis
#12
Hui Dong, Jack Dumenil, Fu-Hao Lu, Li Na, Hannes Vanhaeren, Christin Naumann, Maria Klecker, Rachel Prior, Caroline Smith, Neil McKenzie, Gerhard Saalbach, Liangliang Chen, Tian Xia, Nathalie Gonzalez, Mathilde Seguela, Dirk Inze, Nico Dissmeyer, Yunhai Li, Michael W Bevan
The characteristic shapes and sizes of organs are established by cell proliferation patterns and final cell sizes, but the underlying molecular mechanisms coordinating these are poorly understood. Here we characterize a ubiquitin-activated peptidase called DA1 that limits the duration of cell proliferation during organ growth in Arabidopsis thaliana The peptidase is activated by two RING E3 ligases, Big Brother (BB) and DA2, which are subsequently cleaved by the activated peptidase and destabilized. In the case of BB, cleavage leads to destabilization by the RING E3 ligase PROTEOLYSIS 1 (PRT1) of the N-end rule pathway...
February 6, 2017: Genes & Development
https://www.readbyqxmd.com/read/28164827/occupational-health-and-sleep-issues-in-underserved-populations
#13
REVIEW
Medhat Kalliny, Judith Green McKenzie
Sleep disorders and occupational hazards, injuries, and illnesses impact an individual's overall health. In the United States, substantial racial, ethnic, and socioeconomic disparities exist in sleep and occupational health. Primary care physicians working in underserved communities should be aware of this disparity and target these higher-risk populations for focused evaluation and intervention.
March 2017: Primary Care
https://www.readbyqxmd.com/read/28161135/temporomandibular-total-joint-prosthesis-infections-a-ten-year-retrospective-analysis
#14
W S McKenzie, P J Louis
A retrospective review of 178 total temporomandibular joint replacements (TJR) performed on 106 patients at the University of Alabama at Birmingham during the years 2000-2010 was completed. Data regarding sex, past medical history, prosthesis manufacturer, microbiology, antibiotic therapy, and the need for additional procedures were obtained from the medical records of patients who developed a prosthetic joint infection following TJR. Of the 106 patients, 95 (89.6%) were female and 11 (10.4%) were male. The average age of the patients was 47 years (range 19-68 years)...
February 1, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28159523/a-novel-automated-somatosensory-evoked-potential-ssep-monitoring-device-for-detection-of-intraoperative-peripheral-nerve-injury-in-cardiac-surgery-a-clinical-feasibility-study
#15
Jason Chui, John M Murkin, Timothy Turkstra, Neil McKenzie, Linrui Guo, Mackenzie Quantz
OBJECTIVE: Peripheral nerve injury (PNI) is a common and potentially devastating complication in cardiac surgery. Somatosensory evoked potential (SSEP) monitoring is one of the modalities for PNI; however, its application is limited by complicated logistics. This study aimed to assess the feasibility of using a novel, automated SSEP device (EPAD; SafeOp Surgical, Hunt Valley, MD) for detection of intraoperative PNI during cardiac surgery. DESIGN: Prospective, observational study...
November 17, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28159450/laser-fabrication-of-electrical-feedthroughs-in-polymer-encapsulations-for-active-implantable-medical-devices
#16
Zara Gough, Cedric Chaminade, Philip Barclay-Monteith, Annukka Kallinen, Wenwen Lei, Rajesh Ganesan, John Grace, David R McKenzie
Hermetic electrical feedthroughs are essential for safe and functional active implantable biomedical devices and for a wide range of other applications such as batteries, supercapacitors, OLEDs and solar cells. Ceramics and metals have previously been the materials of choice for encapsulations, while polymers have advantages of ease of mass production and end user compatibility. We demonstrate a laser sealing technology that gives hermetic, mechanically strong feedthroughs with low electrical resistance in a polyetheretherketone (PEEK) encapsulation...
January 31, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28156666/patterns-of-radiation-therapy-technology-use-in-the-treatment-of-bone-metastases
#17
Robert Anton Olson, Shilo Lefresne, Michael R McKenzie
: 211 Background: In recent years, there has been a transition from two-dimensional radiation therapy (2DRT) planning towards more advanced techniques such as three-dimensional conformal radiation therapy (3D-CRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT). Our study aim was to analyze these trends in the treatment of bone metastases. METHODS: All patients aged 18 and older who had received palliative intent RT for bone metastases between 2009-2014 and referred to any 1 of 6 regional cancer centers in British Columbia, Canada were reviewed...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28153046/mitochondrial-dna-point-mutations-and-relative-copy-number-in-1363-disease-and-control-human-brains
#18
Wei Wei, Michael J Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akinibi, Mauro Santibanez-Koref, Kevin Talbot, Martin R Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj, Christopher M Morris, Olaf Ansorge, Stuart Pickering-Brown, James W Ironside, Patrick F Chinnery
Mitochondria play a key role in common neurodegenerative diseases and contain their own genome: mtDNA. Common inherited polymorphic variants of mtDNA have been associated with several neurodegenerative diseases, and somatic deletions of mtDNA have been found in affected brain regions. However, there are conflicting reports describing the role of rare inherited variants and somatic point mutations in neurodegenerative disorders, and recent evidence also implicates mtDNA levels. To address these issues we studied 1363 post mortem human brains with a histopathological diagnosis of Parkinson's disease (PD), Alzheimer's disease (AD), Frontotemporal dementia - Amyotrophic Lateral Sclerosis (FTD-ALS), Creutzfeldt Jacob disease (CJD), and healthy controls...
February 2, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28146450/patient-simulation-for-assessment-of-layperson-management-of-opioid-overdose-with-intranasal-naloxone-in-a-recently-released-prisoner-cohort
#19
Leo Kobayashi, Traci C Green, Sarah E Bowman, Madeline C Ray, Michelle S McKenzie, Josiah D Rich
INTRODUCTION: Investigators applied simulation to an experimental program that educated, trained, and assessed at-risk, volunteering prisoners on opioid overdose (OD) prevention, recognition, and layperson management with intranasal (IN) naloxone. METHODS: Consenting inmates were assessed for OD-related experience and knowledge then exposed on-site to standardized didactics and educational DVD (without simulation). Subjects were provided with IN naloxone kits at time of release and scheduled for postrelease assessment...
February 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28145794/the-effect-of-adverse-childhood-experience-on-clinical-diagnosis-of-a-substance-use-disorder-results-of-a-nationally-representative-study
#20
McKenzie Lynn LeTendre, Mark B Reed
BACKGROUND: Substance abuse is one of the most common health outcomes associated with adverse childhood experience, and poses a significant public health threat. OBJECTIVES: The purpose of this study is to demonstrate a relationship between adverse childhood experience and a substance use disorder using nationally representative data as well as to test whether religion moderates this relationship. METHODS: We conducted a secondary analysis using data from the National Longitudinal Study of Adolescent to Adult Health (n = 11,279)...
February 1, 2017: Substance Use & Misuse
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