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https://www.readbyqxmd.com/read/29677024/how-does-a-changing-climate-impact-the-health-of-workers-part-1-increased-ambient-temperature
#1
Ronda B McCarthy, Judith G McKenzie, William B Perkison, Tee Guidotti, Ismail Nabeel, Mellisa A Pensa
No abstract text is available yet for this article.
April 19, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29677022/a-series-of-joem-forum-articles-discussing-the-potential-impact-of-climate-change-on-the-workplace-and-worker-health
#2
Judith McKenzie
No abstract text is available yet for this article.
April 19, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29676442/shifting-practices-shifting-selves-negotiations-of-local-and-global-cultures-among-adolescents-in-northern-thailand
#3
Jessica McKenzie
Around the world, adolescents increasingly grow up as members of local and global cultures. Little is known, however, about how precisely adolescents in rapidly globalizing societies blend local and global cultures. Interviews with 40 (16- to 19-year old) Thai adolescents, evenly divided between rural and urban communities, were analyzed alongside participant observation data for the interplay between local and global linguistic and dietary practices. Results revealed that urban adolescents inhabited differentiated selves, alternating between local and global practices based on interactional partner...
April 20, 2018: Child Development
https://www.readbyqxmd.com/read/29674595/developmental-and-oncogenic-programs-in-h3k27m-gliomas-dissected-by-single-cell-rna-seq
#4
Mariella G Filbin, Itay Tirosh, Volker Hovestadt, McKenzie L Shaw, Leah E Escalante, Nathan D Mathewson, Cyril Neftel, Nelli Frank, Kristine Pelton, Christine M Hebert, Christine Haberler, Keren Yizhak, Johannes Gojo, Kristof Egervari, Christopher Mount, Peter van Galen, Dennis M Bonal, Quang-De Nguyen, Alexander Beck, Claire Sinai, Thomas Czech, Christian Dorfer, Liliana Goumnerova, Cinzia Lavarino, Angel M Carcaboso, Jaume Mora, Ravindra Mylvaganam, Christina C Luo, Andreas Peyrl, Mara Popović, Amedeo Azizi, Tracy T Batchelor, Matthew P Frosch, Maria Martinez-Lage, Mark W Kieran, Pratiti Bandopadhayay, Rameen Beroukhim, Gerhard Fritsch, Gad Getz, Orit Rozenblatt-Rosen, Kai W Wucherpfennig, David N Louis, Michelle Monje, Irene Slavc, Keith L Ligon, Todd R Golub, Aviv Regev, Bradley E Bernstein, Mario L Suvà
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29670613/innate-immunity-in-the-persistent-inflammation-immunosuppression-and-catabolism-syndrome-and-its-implications-for-therapy
#5
REVIEW
Hiroyuki Horiguchi, Tyler J Loftus, Russell B Hawkins, Steven L Raymond, Julie A Stortz, McKenzie K Hollen, Brett P Weiss, Elizabeth S Miller, Azra Bihorac, Shawn D Larson, Alicia M Mohr, Scott C Brakenridge, Hironori Tsujimoto, Hideki Ueno, Frederick A Moore, Lyle L Moldawer, Philip A Efron
Clinical and technological advances promoting early hemorrhage control and physiologic resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly decreased in-hospital mortality for many critically ill patient populations. However, a substantial proportion of severe trauma and sepsis survivors will develop protracted organ dysfunction termed chronic critical illness (CCI), defined as ≥14 days requiring intensive care unit (ICU) resources with ongoing organ dysfunction...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670294/the-surgical-intelligent-knife-distinguishes-normal-borderline-and-malignant-gynaecological-tissues-using-rapid-evaporative-ionisation-mass-spectrometry-reims
#6
David L Phelps, Júlia Balog, Louise F Gildea, Zsolt Bodai, Adele Savage, Mona A El-Bahrawy, Abigail Vm Speller, Francesca Rosini, Hiromi Kudo, James S McKenzie, Robert Brown, Zoltán Takáts, Sadaf Ghaem-Maghami
BACKGROUND: Survival from ovarian cancer (OC) is improved with surgery, but surgery can be complex and tumour identification, especially for borderline ovarian tumours (BOT), is challenging. The Rapid Evaporative Ionisation Mass Spectrometric (REIMS) technique reports tissue histology in real-time by analysing aerosolised tissue during electrosurgical dissection. METHODS: Aerosol produced during diathermy of tissues was sampled with the REIMS interface. Histological diagnosis and mass spectra featuring complex lipid species populated a reference database on which principal component, linear discriminant and leave-one-patient-out cross-validation analyses were performed...
April 19, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29663560/activation-of-hedgehog-signaling-by-systemic-agonist-improves-fracture-healing-in-aged-mice
#7
Jennifer A McKenzie, Clayton Maschhoff, Xiaochen Liu, Nicole Migotsky, Matthew J Silva, Michael J Gardner
Fracture healing is a complex process of many coordinated biological pathways. This system can go awry resulting in nonunion, which leads to significant patient morbidity. The Hedgehog (Hh) signaling pathway is upregulated in fracture healing. We hypothesized that the Hh signaling pathway can be pharmacologically modulated to positively affect fracture healing. Diaphyseal femur fractures were created in elderly mice (18 months, C57BL/6 females), which have a blunted and delayed healing response compared to younger mice, and were stabilized with intramedullary pins...
April 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29661190/a-manually-annotated-actinidia-chinensis-var-chinensis-kiwifruit-genome-highlights-the-challenges-associated-with-draft-genomes-and-gene-prediction-in-plants
#8
Sarah M Pilkington, Ross Crowhurst, Elena Hilario, Simona Nardozza, Lena Fraser, Yongyan Peng, Kularajathevan Gunaseelan, Robert Simpson, Jibran Tahir, Simon C Deroles, Kerry Templeton, Zhiwei Luo, Marcus Davy, Canhong Cheng, Mark McNeilage, Davide Scaglione, Yifei Liu, Qiong Zhang, Paul Datson, Nihal De Silva, Susan E Gardiner, Heather Bassett, David Chagné, John McCallum, Helge Dzierzon, Cecilia Deng, Yen-Yi Wang, Lorna Barron, Kelvina Manako, Judith Bowen, Toshi M Foster, Zoe A Erridge, Heather Tiffin, Chethi N Waite, Kevin M Davies, Ella P Grierson, William A Laing, Rebecca Kirk, Xiuyin Chen, Marion Wood, Mirco Montefiori, David A Brummell, Kathy E Schwinn, Andrew Catanach, Christina Fullerton, Dawei Li, Sathiyamoorthy Meiyalaghan, Niels Nieuwenhuizen, Nicola Read, Roneel Prakash, Don Hunter, Huaibi Zhang, Marian McKenzie, Mareike Knäbel, Alastair Harris, Andrew C Allan, Andrew Gleave, Angela Chen, Bart J Janssen, Blue Plunkett, Charles Ampomah-Dwamena, Charlotte Voogd, Davin Leif, Declan Lafferty, Edwige J F Souleyre, Erika Varkonyi-Gasic, Francesco Gambi, Jenny Hanley, Jia-Long Yao, Joey Cheung, Karine M David, Ben Warren, Ken Marsh, Kimberley C Snowden, Kui Lin-Wang, Lara Brian, Marcela Martinez-Sanchez, Mindy Wang, Nadeesha Ileperuma, Nikolai Macnee, Robert Campin, Peter McAtee, Revel S M Drummond, Richard V Espley, Hilary S Ireland, Rongmei Wu, Ross G Atkinson, Sakuntala Karunairetnam, Sean Bulley, Shayhan Chunkath, Zac Hanley, Roy Storey, Amali H Thrimawithana, Susan Thomson, Charles David, Raffaele Testolin, Hongwen Huang, Roger P Hellens, Robert J Schaffer
BACKGROUND: Most published genome sequences are drafts, and most are dominated by computational gene prediction. Draft genomes typically incorporate considerable sequence data that are not assigned to chromosomes, and predicted genes without quality confidence measures. The current Actinidia chinensis (kiwifruit) 'Hongyang' draft genome has 164 Mb of sequences unassigned to pseudo-chromosomes, and omissions have been identified in the gene models. RESULTS: A second genome of an A...
April 16, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29660771/integrated-approach-to-oral-health-in-aged-care-facilities-using-oral-health-practitioners-and-teledentistry-in-rural-queensland
#9
Anna Tynan, Lisa Deeth, Debra McKenzie, Carolyn Bourke, Shayne Stenhouse, Jacinta Pitt, Helen Linneman
PROBLEM: Residents of residential aged care facilities are at very high risk of developing complex oral diseases and dental problems. Key barriers exist in delivering oral health services to residential aged care facilities, particularly in regional and rural areas. DESIGN: A quality improvement study incorporating pre- and post chart audits and pre- and post consultation with key stakeholders, including staff and residents, expert opinion on cost estimates and field notes were used...
April 16, 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29652918/a-genome-wide-association-study-of-red-blood-cell-fatty-acids-and-ratios-incorporating-dietary-covariates-framingham-heart-study-offspring-cohort
#10
Anya Kalsbeek, Jenna Veenstra, Jason Westra, Craig Disselkoen, Kristin Koch, Katelyn A McKenzie, Jacob O'Bott, Jason Vander Woude, Karen Fischer, Greg C Shearer, William S Harris, Nathan L Tintle
Recent analyses have suggested a strong heritable component to circulating fatty acid (FA) levels; however, only a limited number of genes have been identified which associate with FA levels. In order to expand upon a previous genome wide association study done on participants in the Framingham Heart Study Offspring Cohort and FA levels, we used data from 2,400 of these individuals for whom red blood cell FA profiles, dietary information and genotypes are available, and then conducted a genome-wide evaluation of potential genetic variants associated with 22 FAs and 15 FA ratios, after adjusting for relevant dietary covariates...
2018: PloS One
https://www.readbyqxmd.com/read/29651596/predictors-of-attendance-to-an-oncologist-referred-exercise-program-for-women-with-breast-cancer
#11
Kelcey A Bland, Sarah E Neil-Sztramko, Amy A Kirkham, Alis Bonsignore, Cheri L Van Patten, Donald C McKenzie, Karen A Gelmon, Kristin L Campbell
PURPOSE: While exercise is associated with numerous benefits in women with breast cancer, adherence to exercise training concurrent to cancer treatment is challenging. We aimed to identify predictors of attendance to an oncologist-referred exercise program offered during and after adjuvant breast cancer treatment. METHODS: Women with early-stage breast cancer receiving chemotherapy (n = 68) enrolled in the Nutrition and Exercise During Adjuvant Treatment (NExT) study...
April 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29645346/identification-of-a-siglec-f-granulocyte-macrophage-progenitor
#12
Jessica E Bolden, Erin C Lucas, Geyu Zhou, Jeremy A O'Sullivan, Carolyn A de Graaf, Mark D McKenzie, Ladina Di Rago, Tracey M Baldwin, Jake Shortt, Warren S Alexander, Bruce S Bochner, Matthew E Ritchie, Douglas J Hilton, Kirsten A Fairfax
In recent years multi-parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pluripotent hematopoietic stem cells, through populations with increasingly limited developmental potential (common myeloid progenitors and granulocyte-macrophage progenitors), to terminally differentiated mature cells. Myeloid progenitors are heterogeneous, and the surface markers that define transition states from progenitors to mature cells are poorly characterized. Siglec-F is a surface glycoprotein frequently used in combination with IL-5 receptor alpha (IL5Rα) for the identification of murine eosinophils...
April 12, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29645343/activation-of-hedgehog-signaling-by-systemic-agonist-improves-fracture-healing-in-aged-mice
#13
Jennifer A McKenzie, Clayton Maschhoff, Xiaochen Liu, Nicole Migotsky, Matthew J Silva, Michael J Gardner
Fracture healing is a complex process of many coordinated biological pathways. This system can go awry resulting in nonunion, which leads to significant patient morbidity. The Hedgehog (Hh) signaling pathway is upregulated in fracture healing. We hypothesized that the Hh signaling pathway can be pharmacologically modulated to positively affect fracture healing. Diaphyseal femur fractures were created in elderly mice (18 months, C57BL/6 females), which have a blunted and delayed healing response compared to younger mice, and were stabilized with intramedullary pins...
April 12, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29643102/research-priority-setting-in-childhood-chronic-disease-a-systematic-review
#14
Harrison Lindsay Odgers, Allison Tong, Pamela Lopez-Vargas, Andrew Davidson, Adam Jaffe, Anne McKenzie, Ross Pinkerton, Melissa Wake, Peter Richmond, Sally Crowe, Patrina Ha Yuen Caldwell, Sophie Hill, Jennifer Couper, Suzy Haddad, Behrouz Kassai, Jonathan C Craig
OBJECTIVE: To evaluate research priority setting approaches in childhood chronic diseases and to describe the priorities of stakeholders including patients, caregivers/families and health professionals. DESIGN: We conducted a systematic review of MEDLINE, Embase, PsycINFO and CINAHL from inception to 16 October 2016. Studies that elicited stakeholder priorities for paediatric chronic disease research were eligible for inclusion. Data on the prioritisation process were extracted using an appraisal checklist...
April 11, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29628419/increased-tumor-glycolysis-characterizes-immune-resistance-to-adoptive-t-cell-therapy
#15
Tina Cascone, Jodi A McKenzie, Rina M Mbofung, Simone Punt, Zhe Wang, Chunyu Xu, Leila J Williams, Zhiqiang Wang, Christopher A Bristow, Alessandro Carugo, Michael D Peoples, Lerong Li, Tatiana Karpinets, Lu Huang, Shruti Malu, Caitlin Creasy, Sara E Leahey, Jiong Chen, Yuan Chen, Helen Pelicano, Chantale Bernatchez, Y N Vashisht Gopal, Timothy P Heffernan, Jianhua Hu, Jing Wang, Rodabe N Amaria, Levi A Garraway, Peng Huang, Peiying Yang, Ignacio I Wistuba, Scott E Woodman, Jason Roszik, R Eric Davis, Michael A Davies, John V Heymach, Patrick Hwu, Weiyi Peng
Adoptive T cell therapy (ACT) produces durable responses in some cancer patients; however, most tumors are refractory to ACT and the molecular mechanisms underlying resistance are unclear. Using two independent approaches, we identified tumor glycolysis as a pathway associated with immune resistance in melanoma. Glycolysis-related genes were upregulated in melanoma and lung cancer patient samples poorly infiltrated by T cells. Overexpression of glycolysis-related molecules impaired T cell killing of tumor cells, whereas inhibition of glycolysis enhanced T cell-mediated antitumor immunity in vitro and in vivo...
March 17, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29620072/neurobehavioral-characterization-of-adult-onset-alexander-disease-a-family-study
#16
Maya L Lichtenstein, Emily Dwosh, Anupama Roy Chowdhury, Matthew J Farrer, Marna B McKenzie, Ilaria Guella, Daniel M Evans, Haakon B Nygaard, Jason R Shewchuk, Sherri Hayden, Jason J S Barton, Howard H Feldman
No abstract text is available yet for this article.
October 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29617572/toward-%C3%AE-secretase-1-inhibitors-with-improved-isoform-selectivity
#17
Patrik Johansson, Karin Kaspersson, Ian K Gurrell, Elisabeth Back, Susanna Eketjäll, Clay W Scott, Gvido Cebers, Philip Thorne, Michael J McKenzie, Haydn Beaton, Paul Davey, Karin Kolmodin, Jorg Holenz, Mark E Duggan, Samantha Budd Haeberlein, Roland Werner Burli
BACE1 is responsible for the first step in APP proteolysis, leading to toxic Aβ production and has been indicated to play a key role in the pathogenesis of Alzheimer's disease. The related isoform BACE2 is thought to be involved in processing of the pigment cell-specific melanocyte protein. To avoid potential effects on pigmentation, we investigated the feasibility for developing isoform-selective BACE1 inhibitors. Co-crystal structures of 47 compounds were analyzed and clustered according to their selectivity profiles...
April 4, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29609547/health-professional-perceptions-regarding-screening-tools-for-developmental-surveillance-for-children-in-a-multicultural-part-of-sydney-australia
#18
Pankaj Garg, My Trinh Ha, John Eastwood, Susan Harvey, Sue Woolfenden, Elisabeth Murphy, Cheryl Dissanayake, Katrina Williams, Bin Jalaludin, Anne McKenzie, Stewart Einfeld, Natalie Silove, Kate Short, Valsamma Eapen
BACKGROUND: Encouraging early child development and the early identification of developmental difficulties is a priority. The Ministry of Health in the Australian State of New South Wales (NSW), has recommended a program of developmental surveillance using validated screening questionnaires, namely, the Parents' Evaluation of Development Status (PEDS) and Ages and Stages Questionnaire (ASQs), however, the use of these tools has remained sub-optimal. A longitudinal prospective birth cohort "Watch Me grow" study was carried out in the South Western Sydney (SW) region of NSW to ascertain the uptake as well as the strategies and the resources required to maximise engagement in the surveillance program...
April 2, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29607520/why-do-couples-seek-relationship-help-online-description-and-comparison-to-in-person-interventions
#19
McKenzie K Roddy, Karen Rothman, Larisa N Cicila, Brian D Doss
Couples are increasingly utilizing newly developed online adaptations of couple therapy; however, different presenting problems could drive couples to seek either online or in-person services. This study compared the presenting problems of 151 couples seeking an online couple intervention for relationship distress (OurRelationship) with responses from 147 couples seeking in-person couple therapy. Presenting problems were generally consistent across gender and whether or not the respondent was the initial help-seeker...
April 2, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29603334/ultrasonography-of-plantar-fibromatosis-updated-case-series-review-of-the-literature-and-a-novel-descriptive-appearance-termed-the-comb-sign
#20
Blake E Cohen, Naveen S Murthy, Gavin A McKenzie
The purpose of this series is to review the appearance of plantar fibromatosis with high-resolution ultrasonography (US) and highlight a new imaging sign termed the "comb sign." A retrospective study was performed for patients with a clinical diagnosis of plantar fibromatosis. Charts of 43 patients (age range, 26-77 years; mean age, 54 years) were reviewed to gather patient demographics and symptoms. Several US characteristics were evaluated with emphasis on any new imaging features. A total of 57 plantar fibromas in 43 patients were examined...
March 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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