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https://www.readbyqxmd.com/read/29664511/bullous-henoch-sch%C3%A3-nlein-purpura-case-report
#1
Trinidad Hasbún, Ximena Chaparro, Viera Kaplan, Felipe Cavagnaro, Alex Castro
Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objec tive: To report an unusual cutaneous manifestation of HSP in children. CASE REPORT: A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthral gias...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29603827/differences-between-acute-onset-chronic-inflammatory-demyelinating-polyneuropathy-a-cidp-and-acute-inflammatory-demyelinating-polyneuropathy-aidp-in-adult-patients
#2
Lucas Alessandro, José M Pastor Rueda, Miguel Wilken, Luis A Querol Gutiérrez, Mariano Marrodán, Julián N Acosta, Alberto Rivero, Fabio Barroso, Mauricio F Farez
Acute Inflammatory Demyelinating Polyneuropathy (AIDP) and Acute-onset Chronic Inflammatory Demyelinating Polyneuropathy (A-CIDP) are conditions presenting overlapping clinical features during early stages (first 4 weeks), although the latter may progress after 8 weeks. The aim of this study was to identify predictive factors contributing to their differential diagnosis. Clinical records of adult patients with AIDP or A-CIDP diagnosed at our institution between January-2006 and July-2017 were retrospectively reviewed...
March 30, 2018: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29595560/spironolactone-as-a-therapeutic-alternative-for-the-bullous-variant-of-central-serous-chorioretinopathy
#3
Eva C Ramos-Yau, Ediberto Muñoz-Domínguez, Silvia P Contreras-Mérida, Luis M Valencia-Londoño
PURPOSE: To report a case of the bullous variant of central serous chorioretinopathy successfully treated with spironolactone, a mineralocorticoid receptor antagonist. METHODS: Case report of a patient including fluorescein angiography, optical coherence tomography, and color fundus photography. RESULTS: Initially managed as a multifocal choroiditis, the use of oral and peribulbar corticoids worsened the serous retinal detachment. Taking in consideration this response, she was then diagnosed with a bullous variant of central serous chorioretinopathy and treated with 50 mg of spironolactone per day...
March 27, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29594223/late-cutaneous-effects-of-a-local-potent-steroid-during-adjuvant-radiotherapy-for-breast-cancer
#4
Eva Ulff, Marianne Maroti, Jörgen Serup, Mats Nilsson, Ursula Falkmer
Purpose: The aim of this study was to evaluate whether treatment with a local potent corticosteroid during adjuvant external radiotherapy (ERT) of breast cancer is associated with late skin toxicity. Material and methods: Sixty patients (32 treated with potent corticoid cream versus 28 controls treated with moisturizer) who had been included in a randomized study on prophylactic local corticosteroid treatment under adjuvant ERT in 2009 and 2010 were subjected to a follow-up study in 2016...
December 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29579858/visceral-leishmaniasis-in-renal-transplant-recipients-report-of-2-cases
#5
F Clavijo Sánchez, T Vázquez Sánchez, M Cabello Díaz, V E Sola Moyano, C Jironada Gallego, D Hernández Marrero
Visceral leishmaniasis is a disease caused by the protozoan Leishmania and is transmitted by Lutzomyia longipalpis (sand fly). It is an endemic parasitic infection in numerous areas around the Mediterranean basin. Though immunocompetent patients may not develop the disease, in transplant recipients the use of corticoids and intensified immunosuppressants to prevent graft rejection may accelerate the disease, causing severe damage to the liver, spleen, and hematopoietic system. We report 2 cases of visceral leishmaniasis with an atypical presentation in transplant recipients...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29564593/advances-in-heart-failure-therapy-in-pediatric-patients-with-dilated-cardiomyopathy
#6
REVIEW
Stefan Rupp, Christian Jux
While in adults major advances in heart failure therapy in patients with dilated cardiomyopathy were documented in the last two decades, research on the mechanism and therapies of heart failure in children with left ventricular dilated cardiomyopathy has lagged behind. Despite the lack of sufficient randomized prospective studies, ACE inhibitors are first line and ß-receptor antagonists are second-line strategies in children. Following the adult guidelines, without having data concerning the pediatric population, mineral corticoids are also accepted in the treatment of pediatric heart failure, while diuretics should only be used to achieve a euvolemic status...
March 22, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29481854/a-possible-principal-function-of-corticosteroid-signaling-that-is-conserved-in-vertebrate-evolution-lessons-from-receptor-knockout-small-fish
#7
REVIEW
Tatsuya Sakamoto, Susumu Hyodo, Wataru Takagi
Corticosteroid receptors are critical for homeostasis maintenance, but understanding of the principal roles of the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) throughout vertebrates is limited. Lines of constitutive GR-knockout zebrafish and MR-knockout medaka have recently been generated as the first adult-viable corticosteroid receptor-knockout animals, in contrast to the lethality of these receptor knockouts in mice. Here, we describe behavioral and physiological modifications following disruption of corticosteroid receptor function in these animal models...
February 23, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29469793/lesiones-subcut%C3%A3-neas-dolorosas-en-paciente-con-melanoma-metast%C3%A3-sico-un-caso-de-paniculitis-linfoc%C3%A3-tica-asociado-a-vemurafenib
#8
Felipe Benavente-Villegas, Francisco Ferrando-Roca, Raquel Dolz-Gaitón, María Royo-Peiró
Vemurafenib ha probado ser una herramienta útil en el tratamiento de melanoma metastásico con mutación BRAF-V600E. Los efectos adversos incluyen artralgias, fatiga y toxicidad cutánea, siendo infrecuente la paniculitis. Presentamos el caso de una paciente de 43 años con melanoma metastásico que desarrolla lesiones subcutáneas dolorosas en miembros inferiores y superiores, asociadas a clínica sistémica después de 2 semanas de inicio de tratamiento con Vemurafenib + Cobimetinib. La histología demostró paniculitis linfocitaria septal y lobulillar...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29433019/exposure-to-bisphenols-and-parabens-during-pregnancy-and-relations-to-steroid-changes
#9
Lucie Kolatorova, Jana Vitku, Richard Hampl, Karolina Adamcova, Tereza Skodova, Marketa Simkova, Antonin Parizek, Luboslav Starka, Michaela Duskova
BACKGROUND: The harmful effects of endocrine disrupting compounds (EDCs) on human health are generally well-known, and exposure during fetal development may have lasting effects. Fetal exposure to bisphenol A (BPA) has been recently relatively well-studied; however, less is known about alternatives such as bisphenol S (BPS), bisphenol F (BPF) and bisphenol AF (BPAF), which have started to appear in consumer products. Parabens are another widespread group of EDCs, with confirmed transplacental passage...
February 9, 2018: Environmental Research
https://www.readbyqxmd.com/read/29417209/rapidly-progressive-interstitial-lung-disease-due-to-anti-mda5-antibodies-without-skin-involvement-a-case-report-and-literature-review
#10
REVIEW
Juan González-Moreno, Manuel Raya-Cruz, Ines Losada-Lopez, Ana Paula Cacheda, Cristina Oliver, Bartomeu Colom
Anti-MDA5 antibodies have been strongly associated with rapidly progressive interstitial lung disease (RP-ILD) in dermatomyositis (DM) patients, especially in the clinically amyopathic subset (CADM). We present a case of anti-MDA5 antibody-associated RP-ILD in a patient with arthritis but with no other clinical signs suggestive of DM or CADM successfully treated with a combination of cyclophosphamide, cyclosporine and corticoids. A review of the literature was also done. Despite its rarity, anti-MDA5 antibody-associated ILD should be suspected in cases of RP-ILD even without other signs of DM or CADM as prompt and aggressive treatment could improve prognosis...
February 7, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29321018/management-and-attitudes-about-ipf-idiopathic-pulmonary-fibrosis-among-physicians-from-latin-america
#11
Iván Cherrez-Ojeda, Vincent Cottin, Juan Carlos Calderón, César Delgado, Erick Calero, Daniel Simanca-Racines, Silvia Quadrelli, Annia Cherrez
BACKGROUND: The aim of our study was to assess current practice patterns and attitudes towards diagnosis and management of idiopathic pulmonary fibrosis (IPF) patients in Latin America. METHODS: A Cross-sectional survey was developed and up to 455 physicians were enrolled. We used a rigorous method of validation using the translated version of the AIR Survey. RESULTS: Mean age was 47.5 years (SD 12.6) with 20.4 years (SD 12.3) of practice...
January 10, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29311198/fungal-peritonitis-caused-by-rhodotorula-mucilaginosa-in-a-capd-patient-treated-with-liposomal-amphotericin-b-a-case-report-and-literature-review
#12
Frédéric Franconieri, Julie Bonhomme, Aline Doriot, Cécile Bonnamy, Maxence Ficheux, Thierry Lobbedez, Clémence Béchade
Rhodotorula mucilaginosa is a ubiquitous yeast that may cause serious peritoneal dialysis (PD) infections. A 70-year-old man receiving continuous ambulatory peritoneal dialysis (CAPD) for 6 months presented with a PD infection caused by Rhodotorula mucilaginosa The patient was treated with intravenous liposomal amphotericin B. His peritoneal catheter was simultaneously removed and reinserted. To date, only 10 cases of Rhodotorula CAPD infections have been reported. Catheters, corticoids, cancer, and previous antibiotic therapy were the main risk factors for these infections...
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29290619/-a-giant-cell-arteritis-revealing-a-goodpasture-s-syndrome
#13
Pascaline M Alix, Amélie Belloi, Émilie Berthoux, Frédérique Dijoud, Emmanuel Villar, Caroline Pariset
Goodpasture's syndrome is a triad of anti-glomerular basement membrane (anti-GBM) circulating antibodies, glomerulonephritis and pulmonary hemorrhage. We reported a 65-year-old woman with headaches, asthenia and weight loss. Giant cell arteritis was confirmed by temporal artery biopsy. The patient had associated renal condition with moderate acute renal failure, proteinuria and haematuria. Renal biopsy showed extracapillary glomerulonephritis and linear staining of immunoglobulins G along glomerular basement membrane...
December 28, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29288858/risk-factors-associated-with-meningitis-after-neurosurgery-a-retrospective-cohort-study-in-a-chinese-hospital
#14
Shengsen Chen, An Cui, Kangkang Yu, Chong Huang, Mengqi Zhu, Mingquan Chen
BACKGROUND: Meningitis is a serious complication occurring after neurosurgical operations, which can result in severe morbidity and high mortality. This retrospective cohort study aimed to determine the risk factors of postoperative meningitis in a large clinical center of neurosurgery in China. METHODS: Patients who underwent a neurosurgical procedure between January 2014 and December 2015 were selected, and 1016 cases were included our final analysis. On the basis of propensity scores, 84 patients with postoperative meningitis were successfully matched to 84 patients without postoperative meningitis...
March 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29285344/a-model-for-the-optimization-of-anti-inflammatory-treatment-with-chemerin
#15
Simao Laranjeira, Daniel Regan-Komito, Asif J Iqbal, David R Greaves, Stephen J Payne, Piotr Orlowski
Routine treatment of mild to moderate pain with a combination of non-steroidal anti-inflammatory drugs such as paracetamol in combination with corticoid opioids can lead to severe complications including death from gastrointestinal injury or to drug dependence. There is a need for the development of new safer drugs. Chemerin is a mediator promoting resolution of inflammation and it is then a promising candidate for a new treatment. A pilot experimental work using the zymosan-induced peritonitis model has found that injecting extra chemerin resulted in an approximately 1% reduction in the total number of inflammatory cells recruited...
February 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29284447/adjunctive-corticosteroid-therapy-for-inpatients-with-mycoplasma-pneumoniae-pneumonia
#16
Masato Tashiro, Kiyohide Fushimi, Kei Kawano, Takahiro Takazono, Tomomi Saijo, Kazuko Yamamoto, Shintaro Kurihara, Yoshifumi Imamura, Taiga Miyazaki, Katsunori Yanagihara, Hiroshi Mukae, Koichi Izumikawa
BACKGROUND: There is conflicting evidence regarding the benefit of adjunctive corticosteroid therapy in patients with Mycoplasma pneumoniae pneumonia. We hypothesised that corticosteroid therapy could reduce mortality and length of stay (LOS) in such patients. METHODS: Adult patients with M. pneumoniae pneumonia from January 2010 to December 2013 were identified from the Japanese Diagnosis Procedure Combination inpatient database. The effects of low-dose and high-dose corticosteroid therapies on mortality, LOS, drug costs and hyperglycaemia requiring insulin treatment were evaluated using propensity score analyses...
December 29, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29241876/update-in-ethiopathogeny-diagnosis-and-treatment-of-the-igg4-related-disease
#17
REVIEW
Fernando Martínez-Valle, Olimpia Orozco-Gálvez, Andreu Fernández-Codina
IgG4 related disease (IgG4-RD) is probably an autoimmune pathology of unknown etiology. Diverse interactions participate in its pathogen between the adaptive and innate immune systems, activating lymphocytes B and T which trigger the inflammatory cascade, which culminates in fibrosis of the organs and their malfunction. It can affect a multitude of organs simultaneously. The diagnosis is based on the correlation of clinical findings with anatomopathological results (lymphoplasmocitary infiltrate, storiform fibrosis, obliterative phlebitis and IgG4+plasmatic cell count) and with the presence of elevated IgG4 in serum, depending on the criteria used...
December 11, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29217977/combined-treatment-of-vigabatrin-and-corticoids-for-infantile-spasms-a-superiority-complex-or-truly-superior-to-corticoids-monotherapy
#18
COMMENT
Ajay Gupta
No abstract text is available yet for this article.
November 2017: Epilepsy Currents
https://www.readbyqxmd.com/read/29204074/academic-stress-induced-changes-in-th1-and-th2-cytokine-response
#19
Areej M Assaf, Reem Al-Abbassi, Maysaa Al-Binni
Psychological stress stimulates physiological responses releasing catecholamines and corticoids, which act via corresponding receptors on immune cells, producing a shift in the cytokine balance. These responses are variable depending on the nature of stressors. The effect of the academic stress on the production of the Th1-cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-6 and IL-8) and Th2-cytokines (IL-1ra, IL-4, IL-5 and IL-10) on 35 medical/health sciences students after completing their questionnaires was investigated...
December 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29171446/do-infections-with-disseminated-mycobacterium-avium-complex-precede-sweet-s-syndrome-a-case-report-and-literature-review
#20
REVIEW
Kenji Hibiya, Kazuya Miyagi, Maki Tamayose, Daijiro Nabeya, Takeshi Kinjo, Syo Takeshima, Nanae Ikemiyagi, Keisuke Yamada, Akane Fujita, Hiroe Hashioka, Wakaki Kami, Morifumi Inamine, Daisuke Shibahara, Hideta Nakamura, Makoto Furugen, Shusaku Haranaga, Futoshi Higa, Masao Tateyama, Jiro Fujita
Sweet's syndrome is reportedly associated with preceding nontuberculous mycobacterial infections (NTMIs). Here, we report on a systemic Mycobacterium intracellulare infection in a patient on corticoid therapy for Sweet's syndrome. Literature searches show that 69.1% of patients with Sweet's syndrome and NTMIs developed this syndrome later than NTMIs and 89.3% of them developed during the clinical course of a rapidly growing mycobacterial infection. The residual cases were associated with slow-growing mycobacteria (14...
October 2017: International Journal of Mycobacteriology
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