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https://www.readbyqxmd.com/read/29909606/dietary-protein-and-nutritional-supplements-in-conventional-hemodialysis
#1
Alice Sabatino, Giovanni Piotti, Carmela Cosola, Ilaria Gandolfini, Jeroen P Kooman, Enrico Fiaccadori
Protein energy wasting (PEW) is a condition commonly occurring among patients with ESRD on hemodialysis. PEW is characterized by depletion of protein and energy stores and is caused by multiple factors related to chronic kidney disease, acute and chronic comorbidities and by renal replacement therapy itself. Anorexia is central in the pathogenesis of PEW; it is frequently observed in these patients whose protein and energy intakes are typically lower than guidelines recommendations. If untreated, PEW invariably leads to major complications, and may activate a vicious circle with further worsening of nutritional status...
June 17, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29909600/patients-knowledge-about-the-outcomes-of-thyroid-biopsy-a-patient-survey
#2
Naykky Singh Ospina, Ana Castaneda-Guarderas, Russell Ward, Juan P Brito, Spyridoula Maraka, Claudia Zeballos Palacios, Kathleen J Yost, Diana S Dean, Victor M Montori
PURPOSE: Fine-needle aspiration biopsy of the thyroid is an increasingly common outpatient procedure. Patients are counseled about the indications and risks of this procedure and informed consent is obtained. We aimed to assess the extent to which patients acquired necessary knowledge during this process. METHODS: Survey study conducted in a thyroid nodule clinic at a referral center. Adult patients who had just undergone a thyroid biopsy were asked to complete a survey, including eight questions regarding the indications and potential outcomes of thyroid biopsy...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29909591/update-on-the-use-of-c1-esterase-inhibitor-replacement-therapy-in-the-acute-and-prophylactic-treatment-of-hereditary-angioedema
#3
REVIEW
H Henry Li, Marc Riedl, Jay Kashkin
In the vast majority of patients with hereditary angioedema (HAE), angioedema attacks are due to the quantitative or functional deficiency of C1-esterase inhibitor (C1-INH), which leads to increased vascular permeability and unregulated release of bradykinin. Exogenous administration of C1-INH is a rational way to restore the concentration and functional activity of this protein, regulate the release of bradykinin, and attenuate or prevent subcutaneous and submucosal edema associated with HAE. Recent international guidelines for the management of HAE include C1-INH as an option for acute treatment of HAE...
June 16, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29909590/do-cta-measurements-of-annular-diameter-perimeter-and-area-result-in-different-tavi-prosthesis-sizes
#4
Barbora Horehledova, Casper Mihl, Babs M F Hendriks, Nienke G Eijsvoogel, Jindrich Vainer, Leo F Veenstra, Joachim E Wildberger, Marco Das
Incorrect prosthesis size has direct impact on patient outcome after transcatheter aortic valve implantation (TAVI) procedure. Currently, annular diameter, area or perimeter may be used for prosthesis size selection. The aim was to evaluate whether the use different annular dimensions would result in the selection of different prosthesis sizes, when assessed in the same TAVI-candidate during the same phase of a cardiac cycle. Fifty consecutive TAVI-candidates underwent retrospectively ECG-gated computed tomography angiography (CTA)...
June 16, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909586/fractal-dimension-brain-morphometry-a-novel-approach-to-quantify-white-matter-in-traumatic-brain-injury
#5
Venkateswaran Rajagopalan, Abhijit Das, Luduan Zhang, Frank Hillary, Glenn R Wylie, Guang H Yue
Traumatic brain injury (TBI) is the main cause of disability in people younger than 35 in the United States. The mechanisms of TBI are complex resulting in both focal and diffuse brain damage. Fractal dimension (FD) is a measure that can characterize morphometric complexity and variability of brain structure especially white matter (WM) structure and may provide novel insights into the injuries evident following TBI. FD-based brain morphometry may provide information on WM structural changes after TBI that is more sensitive to subtle structural changes post injury compared to conventional MRI measurements...
June 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29909584/comparison-of-clinical-results-between-novel-percutaneous-pedicle-screw-and-traditional-open-pedicle-screw-fixation-for-thoracolumbar-fractures-without-neurological-deficit
#6
Ming Yang, Qinpeng Zhao, Dingjun Hao, Zhen Chang, Shichang Liu, Xinhua Yin
OBJECTIVES: To compare the efficacy and safety of novel percutaneous minimally invasive pedicle screw fixation and traditional open surgery for thoracolumbar fractures without neurological deficit. METHODS: Sixty adult patients with single thoracolumbar fracture between June 2014 and June 2016 were recruited in this study, randomly divided into open fixation group (group A) or minimally invasive percutaneous fixation group (group B). Clinical and surgical evaluation including surgery time, blood losses, radiation times, hospital stay, and complication were performed...
June 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29909583/clinical-and-radiographical-ten-years-long-term-outcome-of-microfracture-vs-autologous-chondrocyte-implantation-a-matched-pair-analysis
#7
Robert Ossendorff, Kilian Franke, Benjamin Erdle, Markus Uhl, Norbert P Südkamp, Gian M Salzmann
PURPOSE: To compare the clinical and radiographical long-term outcome of microfracture (MFX) and first-generation periosteum-covered autologous chondrocyte implantation (ACI-P). METHODS: All subjects (n = 86) who had been treated with knee joint ACI-P or microfracture (n = 76) with a post-operative follow-up of at least ten years were selected. Clinical pre- and post-operative outcomes were analyzed by numeric analog scale (NAS) for pain, Lysholm, Tegner, IKDC, and KOOS score...
June 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29909581/switch-maintenance-therapy-with-docetaxel-and-bevacizumab-after-induction-therapy-with-cisplatin-pemetrexed-and-bevacizumab-in-advanced-non-squamous-non-small-cell-lung-cancer-a-phase-ii-study
#8
Koji Nishimoto, Masato Karayama, Naoki Inui, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Nao Inami, Shun Matsuura, Yusuke Kaida, Takashi Matsui, Kazuhiro Asada, Hiroyuki Matsuda, Masato Fujii, Mikio Toyoshima, Shiro Imokawa, Takafumi Suda
Switch maintenance therapy, using alternative agents that were not administered during induction chemotherapy, is a treatment option for advanced non-squamous non-small cell lung cancer (NSCLC). Bevacizumab is known to increase the efficacy of other chemotherapeutic agents; however, switch maintenance therapy with docetaxel and bevacizumab has not been adequately studied. The goal of this study was to evaluate the efficacy and safety of switch maintenance therapy with docetaxel and bevacizumab following induction therapy with cisplatin, pemetrexed, and bevacizumab...
June 16, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29909574/the-possible-antidiabetic-effects-of-vitamin-d-receptors-agonist-in-rat-model-of-type-2-diabetes
#9
Wafaa M Abdel-Rehim, Rasha A El-Tahan, Mennatullah A El-Tarawy, Rowaida R Shehata, Maher A Kamel
Vitamin D3 deficiency was found to be tightly linked to many health problems including metabolic syndrome, cancer, cardiovascular diseases, and type 2 diabetes mellitus. In our study, we tested the possible antidiabetic effects of one of vitamin D3 analogs, alfacalcidol, solely or in a combination with metformin on type 2 diabetic rats. Type 2 diabetic model rats were induced by feeding high-fat diet for 4 weeks followed by intraperitoneal injection of streptozotocin. In addition to the control group, the diabetic rats were divided into four groups: untreated, metformin-treated, alfacalcidol-treated, and combination-treated group (metformin + alfacalcidol) for 4 weeks...
June 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29909567/paravertebral-blocks-reduce-the-risk-of-postoperative-urinary-retention-in-inguinal-hernia-repair
#10
E Bojaxhi, J Lee, S Bowers, R D Frank, S H Pak, A Rosales, S Padron, R A Greengrass
PURPOSE: Inguinal hernia repair and general anesthesia (GA) are known risk factors for urinary retention. Paravertebral blocks (PVBs) have been utilized to facilitate enhanced recovery after surgery. We evaluate the benefit of incorporating PVBs into our anesthetic technique in a large cohort of ambulatory patients undergoing inguinal hernia repair. METHODS: Records of 619 adults scheduled for ambulatory inguinal hernia repair between 2010 and 2015 were reviewed and categorized based on anesthetic and surgical approach [GA and open (GAO), GA and laparoscopic (GAL), PVB and open (PVBO), and GA/PVB and open (GA/PVBO)]...
June 16, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29909560/rhinencephalon-changes-in-tuberous-sclerosis-complex
#11
Renzo Manara, Davide Brotto, Samuela Bugin, Maria Federica Pelizza, Stefano Sartori, Margherita Nosadini, Sara Azzolini, Giorgio Iaconetta, Cecilia Parazzini, Alessandra Murgia, Angela Peron, Paola Canevini, Francesca Labriola, Aglaia Vignoli, Irene Toldo
PURPOSE: Despite complex olfactory bulb embryogenesis, its development abnormalities in tuberous sclerosis complex (TSC) have been poorly investigated. METHODS: Brain MRIs of 110 TSC patients (mean age 11.5 years; age range 0.5-38 years; 52 female; 26 TSC1, 68 TSC2, 8 without mutation identified in TSC1 or TSC2, 8 not tested) were retrospectively evaluated. Signal and morphological abnormalities consistent with olfactory bulb hypo/aplasia or with olfactory bulb hamartomas were recorded...
June 17, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29909558/blood-brain-barrier-permeability-assessed-by-perfusion-computed-tomography-predicts-hemorrhagic-transformation-in-acute-reperfusion-therapy
#12
Taewon Kim, Jaseong Koo, Seong-Hoon Kim, In-Uk Song, Sung-Woo Chung, Kwang-Soo Lee
Hemorrhagic transformation (HT) is one of the most feared complications of acute recanalization therapies. The aim of this study was to evaluate whether blood-brain barrier permeability (BBBP) imaging can predict HT in the setting of acute recanalization therapy and to determine the sensitivity and specificity of BBBP for the prediction of HT according to the type of reperfusion therapy. We assessed a total of 46 patients who received recanalization therapy (intravenous (IV) recombinant tissue plasminogen activator (tPA), mechanical thrombectomy with a stent retriever or both) for acute ischemic stroke within the internal carotid artery or middle cerebral artery...
June 16, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29909552/early-outcomes-of-270-degree-spinal-canal-decompression-by-using-tessys-isee-technique-in-patients-with-lumbar-spinal-stenosis-combined-with-disk-herniation
#13
Chengjie Xiong, Tao Li, Hui Kang, Hao Hu, Jing Han, Feng Xu
PURPOSE: Traditional open approach is an efficient way to treat lumbar spinal stenosis (SS) combined with disk herniation (DH); however, risk factors such as advanced age, osteoporosis etc. are associated with the complications after the surgery. This study aims to analyze the early clinical and radiological outcomes of treatment on SS&DH by using newly developed minimal invasive TESSYS-ISEE technique. METHODS: Patients with limp and unilateral lower limb radiculopathy underwent minimal invasive surgery by using TESSYS-ISEE technique...
June 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29909551/combined-use-of-leptin-and-mechanical-stress-has-osteogenic-effects-on-ossification-of-the-posterior-longitudinal-ligament
#14
Shuai Chen, Haifeng Zhu, Gangliang Wang, Ziang Xie, Jiying Wang, Jian Chen
PURPOSE: To evaluate the effects of leptin/leptin receptor (LepR) combined with mechanical stress on the development of ossification of the posterior longitudinal ligament (OPLL), which is a disease characterized by ectopic bone formation of the posterior longitudinal ligament (PLL) and can lead to radiculopathy and myelopathy. METHODS: Six human samples of the PLL were analyzed for the expression of leptin and LepR by RT-PCR and western blotting. PLL cells were stimulated with leptin and mechanical stress delivered via a Flexcell tension system, and osteogenic differentiation was evaluated by RT-PCR and western blotting analysis of osteogenic marker expression as well as by alkaline phosphatase (ALP) staining and alizarin red S staining...
June 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29909550/methods-for-measuring-risk-for-type-2-diabetes-in-youth-the-oral-glucose-tolerance-test-ogtt
#15
REVIEW
Melinda E Chen, Rebecca S Aguirre, Tamara S Hannon
PURPOSE OF REVIEW: The oral glucose tolerance test (OGTT) is used both in clinical practice and research to assess glucose tolerance. In addition, the OGTT is utilized for surrogate measures of insulin sensitivity and the insulin response to enteral glucose and has been widely applied in the evaluation of β-cell dysfunction in obesity, prediabetes, and type 2 diabetes. Here we review the use of the OGTT and the OGTT-derived indices for measurement of risk markers for type 2 diabetes in youth...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29909549/pharmacokinetics-of-ombitasvir-paritaprevir-ritonavir-and-dasabuvir-in-healthy-chinese-subjects-and-hcv-gt1b-infected-chinese-south-korean-and-taiwanese-patients
#16
Jiuhong Zha, Bifeng Ding, Haoyu Wang, Weihan Zhao, Chen Yu, Katia Alves, Niloufar Mobashery, Yan Luo, Rajeev M Menon
BACKGROUND/PURPOSE: The 3 direct-acting antiviral (3D) regimen of ombitasvir/paritaprevir/ritonavir plus dasabuvir has recently been approved in several Asian geographic regions for the treatment of hepatitis C virus (HCV) genotype (GT) 1 infection. The pharmacokinetics of the components of the 3D regimen with or without ribavirin were evaluated in healthy Chinese subjects and HCV GT1b-infected Chinese, South Korean, and Taiwanese patients, with or without cirrhosis, to determine how the drug exposures in Asian populations compare with historical data in Western populations...
June 16, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29909542/aquatic-community-structure-in-mediterranean-edge-of-field-waterbodies-as-explained-by-environmental-factors-and-the-presence-of-pesticide-mixtures
#17
Ana Santos Pereira, Maria Luísa Dâmaso-Rodrigues, Ana Amorim, Michiel A Daam, Maria José Cerejeira
Studies addressing the predicted effects of pesticides in combination with abiotic and biotic factors on aquatic biota in ditches associated with typical Mediterranean agroecosystems are scarce. The current study aimed to evaluate the predicted effects of pesticides along with environmental factors and biota interactions on macroinvertebrate, zooplankton and phytoplankton community compositions in ditches adjacent to Portuguese maize and tomato crop areas. Data was analysed with the variance partitioning procedure based on redundancy analysis (RDA)...
June 16, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29909538/resistant-hypertension-time-to-consider-the-best-fifth-anti-hypertensive-treatment
#18
REVIEW
Andrea Pio-Abreu, Luciano F Drager
PURPOSE OF REVIEW: Resistant hypertension (RH) is a growing clinical condition worldwide associated with target-organ damage and poor prognosis compared to non-resistant counterparts. The purpose of this review is to perform a critical evaluation of preferable drug choices for managing RH highlighting the evidence that significant proportion of patients remained uncontrolled despite using four anti-hypertensive drugs. RECENT FINDINGS: Until recently, the fourth drug therapy was main derived from personal opinion or small interventional studies...
June 16, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29909532/monthly-dynamics-of-atmospheric-wet-nitrogen-deposition-on-different-spatial-scales-in-china
#19
Qiongyu Zhang, Qiufeng Wang, Li Xu, Jianxing Zhu, Nianpeng He
China is one of three global hotspots for nitrogen (N) deposition, which has concerned scientists and the public. While previous studies on N deposition in China have focused on its composition, spatial pattern, and interannual dynamics, its monthly dynamics in different regions remain unclear, hindering our ability to evaluate its ecological effects. Therefore, we obtained monthly wet N deposition data from196 sites after continuous network observations and published data in China and analyzed the monthly dynamics of NH4 + -N, NO3 - -N, and dissolved inorganic N (DIN=NH4 + -N+NO3 - -N) deposition fluxes on site, regional, and national scales...
June 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29909530/impact-of-affected-lymph-nodes-on-long-term-outcome-after-surgical-therapy-of-alveolar-echinococcosis
#20
Andreas Hillenbrand, Annika Beck, Wolfgang Kratzer, Tilmann Graeter, Thomas F E Barth, Julian Schmidberger, Peter Möller, Doris Henne-Bruns, Beate Gruener
PURPOSE: Alveolar echinococcosis (AE) is a life-threatening helminthic disease. In humans, AE mostly affects the liver; the regional hepatic lymph nodes may be involved, indicating dissemination of AE from the liver. To achieve complete removal of the disease, enlarged hepatic lymph nodes may be resected during surgical treatment. We evaluated the frequency of affected lymph nodes by conventional microscopic and immunohistochemical analyses including detection of small particles of Echinococcus multilocularis (spem)...
June 16, 2018: Langenbeck's Archives of Surgery
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