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Hepatic arterial infusion chemotherapy

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https://www.readbyqxmd.com/read/29682747/contribution-of-equilibrative-nucleoside-transporters-1-and-2-to-gemcitabine-uptake-in-pancreatic-cancer-cells
#1
Masato Hioki, Takuya Shimada, Tian Yuan, Takeo Nakanishi, Hidehiro Tajima, Maiko Yamazaki, Rina Yokono, Makiko Takabayashi, Kazuki Sawamoto, Gaku Akashita, Ken-Ichi Miyamoto, Tetsuo Ohta, Ikumi Tamai, Tsutomu Shimada, Yoshimichi Sai
Hepatic arterial infusion (HAI) chemotherapy is expected to be a more effective and safer method to treat the hepatic metastasis of pancreatic cancer than intravenous (i.v.) administration because of higher tumor exposure and lower systemic exposure. To clarify the uptake mechanism of nucleoside anticancer drugs, including gemcitabine (GEM), in pancreatic cancer, we investigated the uptakes of radiolabeled uridine (a general substrate of nucleoside transporters) and GEM in pancreatic cancer cell lines MIA-PaCa2 and As-PC1...
April 22, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29650828/-a-case-of-locally-advanced-intrahepatic-cholangiocarcinoma-successfully-treated-by-conversion-surgery-after-hepatic-arterial-infusion-chemotherapy-and-radiation-therapy
#2
Ko Sugiyama, Toshiya Kamiyama, Takumi Ohmura, Akihisa Nagatsu, Shingo Shimada, Takahiro Einama, Kenji Wakayama, Tatsuya Orimo, Hideki Yokoo, Hirofumi Kamachi, Akinobu Taketomi
The patient was a 63-year-old man. Computed tomography(CT)showed a 99mm in diameter low-density mass in hepatic segments 4 and 8 as the main locus. This tumor was diagnosed as intrahepatic cholangiocarcinoma and was suspected to invade to left and right Gleason's sheath, and radical cure was judged impossible. After hepatic arterial chemotherapy and radiotherapy were performed, tumor shrinkage was confirmed, and tumor markers also became negative. So he was referred to our hospital for surgical indication. CT revealed that the tumor did not invade to the left Gleason's sheath...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29645345/comparison-of-clinical-outcome-of-hepatic-arterial-infusion-chemotherapy-and-sorafenib-for-advanced-hepatocellular-carcinoma-according-to-macrovascular-invasion-and-transcatheter-arterial-chemoembolization-refractory-status
#3
Kenichiro Kodama, Tomokazu Kawaoka, Hiroshi Aikata, Shinsuke Uchikawa, Yuki Inagaki, Masahiro Hatooka, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Keiichi Masaki, Yoji Honda, Nami Mori, Shintaro Takaki, Keiji Tsuji, Hirotaka Kohno, Hiroshi Kohno, Takashi Moriya, Michihiro Nonaka, Hideyuki Hyogo, Yasuyuki Aisaka, Kazuaki Chayama
AIM: Sorafenib is the standard treatment for patients with advanced hepatocellular carcinoma (HCC) with distant metastasis, unresectable HCC, and HCC refractory to transcatheter arterial chemoembolization (TACE) or with macroscopic vascular invasion (MVI). Also, hepatic arterial infusion chemotherapy (HAIC) has been used for advanced HCC in Southeast and East Asian countries. However, clearer information is needed for choosing appropriately between these therapies. METHODS: The subjects were 391 HAIC and 431 sorafenibs administered at our hospital and related hospitals...
April 12, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29553105/arterial-infusion-of-cisplatin-plus-s-1-against-unresectable-intrahepatic-cholangiocarcinoma
#4
Tokio Higaki, Osamu Aramaki, Masamichi Moriguchi, Hisashi Nakayama, Yutaka Midorikawa, Tadatoshi Takayama
Conventional regimens for unresectable intrahepatic cholangiocarcinoma are considered of limited effectiveness. To evaluate the efficacy and toxicity of combination chemotherapy with hepatic arterial infusion of IA-call (a fine-powder formulation of cisplatin) plus oral S-1 in patients with unresectable intrahepatic cholangiocarcinoma. The clinicopathological data and long-term outcome of 12 patients who were received with IA-call plus S-1 were compared with those of 16 patients who were received other treatments, such as radiation therapy, trans-arterial chemoembolization, and systemic chemotherapy...
2018: Bioscience Trends
https://www.readbyqxmd.com/read/29509591/phase-i-ii-study-of-hepatic-arterial-infusion-of-nab-paclitaxel-in-patients-with-metastatic-melanoma-to-the-liver
#5
Jesus Vera-Aguilera, Agop Y Bedikian, Roland L Bassett, Wen-Jen Hwu, Kevin B Kim, Yong Qin, Suzanne Cain, Edwina W Washington, Michael A Davies, Sunil M Patel, Jade Homsi, Nicholas E Papadopoulos, Patrick Hwu, Sapna P Patel
OBJECTIVES: Hepatic arterial infusion (HAI) of cytotoxic chemotherapy is a strategy to deliver high dose of anticancer therapy to liver metastases that derive their blood supply from the hepatic artery. Metastatic melanoma (MM) has a high incidence of liver metastases, with uveal subtype in particular exhibiting a predilection for liver dissemination. Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) has demonstrated efficacy in MM and first-pass hepatic metabolism. Therefore, we hypothesized that HAI of nab-paclitaxel would deliver an effective dose of drug to the end organ of interest, with minimal systemic exposure...
March 5, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29503565/postoperative-hepatic-arterial-infusion-chemotherapy-improved-survival-of-pancreatic-cancer-after-radical-pancreatectomy-a-retrospective-study
#6
Yongchun Wang, Yongqiang Xu, Yinyuan Zheng, Ying Bao, Ping Wang
Objective: To determine the effect of postoperative hepatic arterial infusion chemotherapy (HAIC) on long-term survival of patients with pancreatic cancer (PC) after radical pancreatectomy. Methods: A total of 87 patients with PC underwent radical pancreatectomy in the First People's Hospital affiliated to Huzhou Normal College between June 2008 and May 2013. Among these patients, after surgery, 43 received two sessions of HAIC followed by four sessions of systemic chemotherapy (HAIC group), while 44 received six sessions of systemic chemotherapy alone (control group)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29487726/complete-response-in-a-patient-with-liver-metastases-from-breast-cancer-employing-hepatic-arterial-infusion-5-fluorouracil-based-chemotherapy-plus-systemic-nab-paclitaxel
#7
Girolamo Ranieri, Ilaria Marech, Mariangela Porcelli, Francesco Giotta, Gennaro Palmiotti, Giuseppe Laricchia, Vito Fazio, Cosmo Damiano Gadaleta
About half of patients with metastatic breast cancer (mBC) have unresectable liver metastases (LMs) or liver-predominant disease (LPD). Unfortunately systemic chemotherapy has limited tumor response due to LMs are supplied by hepatic artery. Hepatic intra-arterial (HAI) have antitumor activity in pretreated patients with LMs. Here we report the case of a 55-year-old woman affected by BCLPD and heavily pretreated. LMs responded to treatment based on HAI with 5-fluorouracil and nab-paclitaxel systemic chemotherapy, and they completely disappeared on a CT-scan...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29483426/-a-case-of-a-long-term-survivor-who-underwent-surgical-intervention-for-hepatocellular-carcinoma-combined-with-tumor-thrombus-in-the-main-trunkof-the-portal-vein
#8
Shigeru Fujisaki, Motoi Takashina, Ryouichi Tomita, Kenichi Sakurai, Tadatoshi Takayama
We reported a patient survived more than 7years after undergoing hepatectomy accompanied by tumor thrombectomy in the main trunk of the portal vein after preoperative hepatic arterial chemotherapy for hepatocellular carcinoma combined with tumor thrombus in the main portal vein. A 58-year-old man underwent hepatic arterial infusion therapy with 5-fluorouracil( 5-FU)plus cisplatin(CDDP)for 6 weeks for a solitary 7cm nodule of hepatocellular carcinoma on the liver(S6) with tumor thrombus in the main portal vein...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29428943/comparison-of-outcome-of-hepatic-arterial-infusion-chemotherapy-combined-with-radiotherapy-and-sorafenib-for-advanced-hepatocellular-carcinoma-patients-with-major-portal-vein-tumor-thrombosis
#9
Kenichiro Kodama, Tomokazu Kawaoka, Hiroshi Aikata, Shinsuke Uchikawa, Yuno Nishida, Yuki Inagaki, Masahiro Hatooka, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Keiichi Masaki, Yoji Honda, Nami Mori, Shintaro Takaki, Keiji Tsuji, Hirotaka Kohno, Hiroshi Kohno, Takashi Moriya, Michihiro Nonaka, Hideyuki Hyogo, Yasuyuki Aisaka, Tomoki Kimura, Yasushi Nagata, Kazuaki Chayama
OBJECTIVE: To compare the outcome of hepatic arterial infusion chemotherapy combined with radiotherapy (HAIC + RT) versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma (HCC) and major portal vein tumor thrombosis (PVTT). METHODS: This retrospective study included 108 HCC patients with PVTT of the main trunk or first branch and Child-Pugh ≤7. Sixty-eight received HAIC + RT and 40 received sorafenib. Patients were then assigned to the HAIC + RT group (n = 36) and the sorafenib group (n = 36) through case-control matching...
February 9, 2018: Oncology
https://www.readbyqxmd.com/read/29394731/-a-case-of-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-treated-successfully-with-multidisciplinary-therapy-including-preoperative-stereotactic-body-radiotherapy-sbrt
#10
Sadaaki Nishimura, Akira Tomokuni, Shogo Kobayashi, Kei Asukai, Hirofumi Akita, Hidenori Takahashi, Yoshitomo Yanagimoto, Yusuke Takahashi, Norikatsu Miyoshi, Keijiro Sugimura, Kazuyoshi Yamamoto, Takeshi Ohmori, Masayuki Ohue, Masahiko Yano, Masato Sakon
A 61-year-old man untreated with hepatitis C virus presented to our hospital.He was diagnosed advanced hepatocellular carcinoma(HCC)with portal vein tumor thrombosis(PVTT).The hazy tumor was located in the left lobe, and the tumor thrombus extended into the left portal vein.The patient received stereotactic body radiotherapy(SBRT, 48 Gy/4 Fr)for PVTT. The extended left lobectomy with thrombectomy was performed 12 days after SBRT.Resected specimen was diagnosed histopathologically as a poorly differentiated HCC, vp1, and no viable tumor cells in the tumor thrombosis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394623/-two-cases-of-achieving-a-pathological-complete-response-via-hepatic-arterial-infusion-chemotherapy-for-liver-limited-and-unresectable-liver-metastases-from-colorectal-cancer-with-ras-mutations
#11
Michiko Hamanaka, Masafumi Noda, Ayako Imada, Jihyung Song, Kei Kimura, Akihito Babaya, Masayoshi Kobayashi, Kiyoshi Tsukamoto, Tomoki Yamano, Masataka Ikeda, Naohiro Tomita
We had 2 cases of liver-limited and unresectable liver metastases from colorectal cancer with RAS mutations. These patients received hepatic arterial infusion chemotherapy(HAI), finally achieving pCR. Case 1 was a 76-year-old female with rectosigmoid cancer and multiple liver metastases. We underwent anterior resection for primary lesion. After surgery, the patient had received first-line and second-line systemic chemotherapy for the multiple liver metastases. The patient achieved SD and had Grade 3 neutropenia...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394597/-a-case-of-long-term-survival-with-multidisciplinary-therapy-for-a-patient-with-multiple-metastases-from-rectal-cancer
#12
Yu Mikane, Megumi Watanabe, Dofu Hayashi, Takayoshi Miyake, Saki Katayama, Ryohei Syoji, Yoshinori Kajiwara, Daisuke Konishi, Motoyasu Tabuchi, Katsuyuki Aoyama, Tomohiro Nogami, Hitoshi Nishikawa, Susumu Shinoura, Kaori Shigemitsu, Yasuyuki Nonaka
Combined modality therapy is sufficient to treat advanced rectal cancer with multiple metastases. Her, we report a case of long-term survival in a patient with multiple metastases from rectal cancer. A5 8-year-old man had previously undergone low anterior resection for advanced rectal cancer. Multiple liver and lung metastases were identified prior to operation; therefore, we initiated chemotherapy(FOLFOX). Partial resection of metastatic lesions and radiofrequency ablation(RFA)were also administered, but newly developed liver, lung, and adrenal gland metastases were identified...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394595/-two-cases-of-colon-cancer-with-severe-liver-dysfunction-due-to-multiple-liver-metastases-effectively-treated-with-hepatic-arterial-infusion-chemotherapy-plus-cetuximabfollowed-by-systemic-chemotherapy
#13
Fukuichiro Orita, Toshiaki Ishikawa, Megumi Sasaki, Tomiyuki Miura, Michiyo Tokura, Marie Hanaoka, Shinichi Yamauchi, Akifumi Kikuchi, Megumi Ishiguro, Masamichi Yasuno, Hiroyuki Uetake
Case 1: An 80-year-old man was diagnosed with cecal cancer plus multiple liver metastases and peritoneal disseminations. He underwent surgical resection of the primary tumor to prevent bowel obstruction. Initially, hepatic arterial infusion(HAI) plus cetuximab(Cmab)was administered to reduce the size of the metastatic tumors and prevent liver failure. A partial response(PR)was observed in the liver metastases after 12 courses of treatment and S-1 plus oxaliplatin(SOX)plus bevacizumab was started. Case 2: A 44-year-old man was diagnosed with sigmoid colon cancer with multiple liver, lung and bone metastases, and with obstructive jaundice and cholangitis due to severe liver hilum lymph node metastases...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29362350/-a-case-of-hepatocellular-carcinoma-with-right-atrium-tumor-thrombus-and-multiple-intrahepatic-metastases-that-remarkably-responded-to-combination-therapy-including-surgery
#14
Toru Otsuru, Shogo Kobayashi, Hidetoshi Eguchi, Hiroshi Wada, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Koji Umeshita, Yuichiro Doki, Masaki Mori
The prognosis for hepatocellular carcinoma(HCC)with right atrium tumor thrombus(RATT)is dismal and necessary to be treated on as oncologic emergency. We report a case of HCC with RATT which was treated with multidisciplinary therapy including surgery. After repeated transarterial chemoembolization(TACE)and radiofrequency ablation(RFA), a 71-year-old man consulted to our hospital with multiple HCC, lung metastasis, and RATT. Left hemihepatectomy, thrombectomy of RATT, and 3 months of hepatic arterial infusion chemotherapy(HAIC)was performed, and intrahepatic HCCs were controlled...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29362348/-a-case-of-study-stable-disease-after-hepatic-arterial-infusion-chemotherapy-in-a-patient-with-systemic-chemotherapy-resistant-liver-metastases-of-colon-cancer
#15
Hiroyuki Ishiodori, Koichi Doi, Fumimasa Kitamura, Norio Uemura, Takeyoshi Kaida, Tetsufumi Ohchi
A 62-year-old man was underwent sigmoidectomy for sigmoid colon cancer(T3N1H0P0, Stage III a). He received a postoperative systemic chemotherapy with SOX. Five months after the operation, multiple liver metastases were detected by CT scan. Systemic chemotherapy(bevacizumab and SOX, bevacizumab and FOLFIRI)did not reduce the liver metastases. So 4 courses of hepatic arterial infusion(HAI)chemotherapy with CDDP 10mg/day and 5-FU 500mg/day for 2weeks were performed without severe adverse events. All the liver metastases decreased in size remarkably, and the hepatic resection was able to be performed...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29359012/hepatectomy-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus
#16
REVIEW
Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Kenji Wakayama
Despite surgical removal of tumors with portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) patients, early recurrence tends to occur, and overall survival (OS) periods remain extremely short. The role that hepatectomy may play in long-term survival for HCC with PVTT has not been established. The operative mortality of hepatectomy for HCC with PVTT has also not been reviewed. Hence, we reviewed recent literature to assess these parameters. The OS of patients who received hepatectomy in conjunction with multidisciplinary treatment tended to be superior to that of patients who did not...
December 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29353981/retrospective-analysis-of-interventional-treatment-of-hepatic-metastasis-from-gastroenteropancreatic-neuroendocrine-tumors
#17
Peng Liu, Xu Zhu, Jie Li, Ming Lu, Jiahua Leng, Ying Li, Jiangyuan Yu
Objective: To analyze the angiography appearance of liver metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs), and evaluate the clinical efficacy and prognostic factors of interventional treatment for hepatic metastases. Methods: Fifty GEP-NETs patients with hepatic metastases were treated from January 2012 to December 2016, and received transarterial embolization (TAE) in the hepatic tumor or hepatic arterial infusion chemotherapy (HAIC). All patients received 179 times of the intervention therapy in total...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29346784/surgical-treatment-and-chemotherapy-of-adult-primary-liver-sarcoma-experiences-from-a-single-hospital-in-china
#18
Feng Zhou, Han-Zhang Huang, Meng-Tao Zhou, Shao-Liang Han
BACKGROUND: The aim of this study is to improve the preoperative diagnostic accuracy and treatment results by investigating the clinical features and prognosis of primary liver sarcoma (PLS). METHODS: Clinical data, surgical treatments, adjuvant chemotherapy, and prognosis of 17 PLS patients whose diseases were pathologically confirmed were retrospectively analyzed. RESULTS: The main clinical symptoms included epigastric pain in 9 patients, epigastric distention in 7, and loss of appetite in 4; these symptoms were detected during the postoperative follow-up for gastric carcinoma in 1...
January 18, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29327075/phase-ii-study-of-sorafenib-combined-with-concurrent-hepatic-arterial-infusion-of-oxaliplatin-5-fluorouracil-and-leucovorin-for-unresectable-hepatocellular-carcinoma-with-major-portal-vein-thrombosis
#19
Min-Ke He, Ru-Hai Zou, Qi-Jiong Li, Zhong-Guo Zhou, Jing-Xian Shen, Yong-Fa Zhang, Zi-Shan Yu, Li Xu, Ming Shi
BACKGROUND: Sorafenib is recommended for the first-line treatment of advanced hepatocellular carcinoma (HCC). However, the median progression-free survival (PFS) of patients with HCC and major portal vein tumor thrombosis treated with sorafenib monotherapy is no more than 3 months. A prospective single-arm phase II study was conducted to determine whether adding hepatic arterial infusion chemotherapy of oxaliplatin, 5-fluorouracil and leucovorin to sorafenib could improve on these results...
May 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29290599/hepatic-arterial-infusion-in-the-management-of-colorectal-cancer-liver-metastasis-current-and-future-perspectives
#20
REVIEW
Nicolas Chapelle, Tamara Matysiak-Budnik, Frédéric Douane, Sylvie Metairie, Philippe Rougier, Yann Touchefeu
The technique of hepatic arterial infusion (HAI) for the treatment of liver metastases from colorectal cancer has been developed over more than 30 years. Although the indications and protocols for this technique have evolved with time, HAI is not routinely performed in clinical practice. Studies have been heterogeneous, with different regimens of intra-arterial drugs, associated or not with systemic chemotherapy, and with unconvincing outcomes. Technical difficulties for catheter placement have limited the implementation of this method in routine practice...
March 2018: Digestive and Liver Disease
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