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lecithin, serum acetylcholine

Ting Zhang, Hengyan Qu, Xuling Li, Baoquan Zhao, Jianping Zhou, Qian Li, Manji Sun
For a long time, people have been looking forward to being able to clinically deliver bio-drugs systemically by a noninvasive method. Here, we show that a synthetic peptide, TD (ACSSSPSKHCG) was efficient in transferring human growth hormone (GH) across various kinds of membranes and the blood-brain barrier (BBB) in vivo via rectal administration, resulting in elevation of GH level in serum, acetylcholine and O-choline acetyltransferase activities and GH /IGF-1 contents in brain tissues, manifesting great therapeutic effects on chronic age-related dementia in mice and ameliorating neuronal damage in the brain...
December 2010: Journal of Pharmaceutical Sciences
Tetsuya Nakamura, Yuichiro Saito, Yoshio Ohyama, Tsuyoshi Uchiyama, Hiroyuki Sumino, Masahiko Kurabayashi
A mutation of the CD36 gene that encodes a fatty acid transporter has been reported to play a role in insulin resistance in spontaneously hypertensive rat (SHR). Statins reduce circulating cholesterol and triglyceride concentrations. The objective of this study was to determine the role of CD36 and the significance of statin therapy in insulin-resistance syndromes. We determined the isometric relaxation induced by acetylcholine or lecithinized superoxide dismutase (SOD) in aortas obtained from Otsuka Long Evans Tokushima Fatty (OLETF) rats, a model of insulin resistance and dyslipidemia, and normal control (Long Evans Tokushima Otsuka; LETO) rats with or without cerivastatin treatment...
August 2004: Hypertension Research: Official Journal of the Japanese Society of Hypertension
S Jakob, R Mosenthin, G Huesgen, J Kinkeldei, K J Poweleit
Athletes especially experience a significant decrease in plasma choline concentrations during exercise which can be compensated in part by consumption of lecithin, a natural source of choline. In addition, the effect of lecithin on plasma choline concentrations in humans is obviously considerably greater and more prolonged than that of an equivalent amount of choline salts. Serum choline acts as a precursor for the synthesis of acetylcholine, which, in turn, acts as a neurotransmitter. The effect of dietary choline derived from either choline chloride or lecithin on the diurnal pattern of free choline concentrations in serum was studied using the pig as a potential model for humans...
December 1998: Zeitschrift F√ľr Ern√§hrungswissenschaft
S G Magil, S H Zeisel, R J Wurtman
Rats were fed lecithins, derived from eggs or soybeans, to determine whether the fatty acid composition of the phosphatidylcholine altered choline availability. Rats were fed either a single meal containing 5 g phosphatidylcholine or a lecithin-containing diet for 3 weeks, including approximately 5 g phosphatidylcholine per day. Each form of dietary lecithin elevated blood choline, brain choline and brain acetylcholine significantly (P < 0.05). There was no difference in response to egg- or soy-derived lecithin...
January 1981: Journal of Nutrition
P L Rabin, B R Gooch, P E Teschan, D E Schmidt, D P Island, D Rabin
Four normal subjects received lecithin supplements sufficient to elevate serum choline levels 3-fold. Despite persistent hypercholinemia over 48 hours of close observation, no increase was observed in serum ACTH, cortisol, and insulin concentrations, or in free urinary catecholamine excretion. Screening of a large group of other pituitary and gonadal hormones also failed to reveal any influence of lecithin supplements. EEG patterns and results of psychometric tests were also unaltered.
April 1983: Journal of Clinical Psychiatry
N D Zvezdina, N V Prokasova, V A Vaver, L D Bergelson, T M Turpaev
No abstract text is available yet for this article.
1978: Biochemical Pharmacology
R J Wurtman, M J Hirsch, J H Growdon
Consumption of choline by rats sequentially increases serum-choline, brain-choline, and brain-acetylcholine concentrations. In man consumption of choline increases in levels in the serum and cerebrospinal fluid; its administration is an effective way of treating tardive dyskinesia. We found that oral lecithin is considerably more effective in raising human serum-choline levels than an equivalent quantity of choline chloride. 30 minutes after ingestion of choline chloride (2-3 g free base), serum-choline levels rose by 86% and returned to normal values within 4 hours; 1 hour after lecithin ingestion, these levels rose by 265% and remained significantly raised for 12 hours...
July 9, 1977: Lancet
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