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https://www.readbyqxmd.com/read/29444257/comparison-of-strategies-and-incidence-thresholds-for-vi-conjugate-vaccines-against-typhoid-fever-a-cost-effectiveness-modeling-study
#1
Nathan C Lo, Ribhav Gupta, Jeffrey D Stanaway, Denise O Garrett, Isaac I Bogoch, Stephen P Luby, Jason R Andrews
Background: Typhoid fever remains a major public health problem globally. While new Vi conjugate vaccines hold promise for averting disease, the optimal programmatic delivery remains unclear. We aimed to identify the strategies and associated epidemiologic conditions under which Vi conjugate vaccines would be cost-effective. Methods: We developed a dynamic, age-structured transmission and cost-effectiveness model that simulated multiple vaccination strategies with a typhoid Vi conjugate vaccine from a societal perspective...
February 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29424432/human-metapneumovirus-in-hospitalized-children-less-than-five-years-of-age-in-pakistan
#2
Mohammad Tahir Yousafzai, Romesa Ibrahim, Rozina Thobani, Fatima Aziz, Asad Ali
BACKGROUND: Acute respiratory infection (ARI) is the second leading cause of death in children less than five years of age worldwide. Human Metapneumovirus (hMPV) is associated with around 5-7% of the total pneumonia admissions in children. The aim of this study was to determine the magnitude of hMPV associated hospitalizations among children, in Karachi, Pakistan. METHODOLOGY: A three years prospective study was conducted at the Aga Khan University Hospital (AKUH), from August 2009 to June 2012...
February 9, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29387980/hyperpyrexia-and-high-fever-as-a-predictor-for-serious-bacterial-infection-sbi-in-children-a-systematic-review
#3
REVIEW
Noa Rosenfeld-Yehoshua, Shiri Barkan, Ibrahim Abu-Kishk, Meirav Booch, Ruth Suhami, Eran Kozer
It is not clear if children with high fever are at increased risk for serious bacterial infection (SBI). Our aim was to systematically review if children suffering from high fever are at high risk for SBI. Our data sources were Embase, Medline, and Pubmed; from their inception until the last week of March 2017. The study selection were of cohort and case control studies comparing the incidence of SBI in children with hyperpyrexia with children with fever of 41 °C or less, and children with a temperature higher than 40 °C, with children with fever of 40 °C or less...
January 31, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29380724/relationships-among-common-illness-symptoms-and-the-protective-effect-of-breastfeeding-in-early-childhood-in-mal-ed-an-eight-country-cohort-study
#4
Stephanie A Richard, Benjamin J J McCormick, Jessica C Seidman, Zeba Rasmussen, Margaret N Kosek, Elizabeth T Rogawski, William Petri, Anurahda Bose, Estomih Mduma, Bruna L L Maciel, Ram Krishna Chandyo, Zulfiqar Bhutta, Ali Turab, Pascal Bessong, Mustafa Mahfuz, Laura E Caulfield, On Behalf Of The Mal-Ed Network Investigators
Children in low-income countries experience multiple illness symptoms in early childhood. Breastfeeding is protective against diarrhea and respiratory infections, and these illnesses are thought to be risk factors of one another, but these relationships have not been explored simultaneously. In the eight-site MAL-ED study, 1,731 infants were enrolled near birth and followed for 2 years. We collected symptoms and diet information through twice-weekly household visits. Poisson regression was used to determine if recent illness history was associated with incidence of diarrhea or acute lower respiratory infections (ALRI), accounting for exclusive breastfeeding...
January 29, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29357899/pediatric-multi-drug-resistant-tuberculosis-and-hiv-co-infection-in-a-resource-limited-setting-a-case-report
#5
Christelle Géneviève Jouego, Valirie Ndip Agbor, Juergen Noeske, Ndo Akono Manuel, Leo Njock Ayuk
BACKGROUND: Tuberculosis remains a major cause of morbidity and mortality worldwide, especially in developing countries. The diagnosis and treatment of multi-drug resistant tuberculosis (MDR-TB) in children remain a major limitation in this setting, largely due to difficulties in isolating Mycobacterium tuberculosis from pediatric specimens, management with toxic second line drugs, and practically the inexistence of contact tracing. In 2016, the World Health Organization (WHO) recommended a standardized 9-month regimen for adults and children in zones which are highly endemic for the human immunodeficiency virus (HIV)...
January 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29351594/sero-efficacy-of-vi-polysaccharide-tetanus-toxoid-typhoid-conjugate-vaccine-typbar-tcv
#6
Merryn Voysey, Andrew J Pollard
Background: Salmonella Typhi is the major cause of enteric fever in lower income countries. New conjugate vaccines show promise as public health interventions, however there are no efficacy data available from endemic areas. Methods: Data were obtained from a previously published phase 3 randomised controlled trial comparing Vi-polysaccharide tetanus-toxoid conjugate vaccine (Typbar-TCV; Bharat Biotech Intl Ltd, India): (Vi-TT) with Vi-polysaccharide (Typbar; Bharat Biotech Intl Ltd, India): (Vi-PS) in participants aged 2- 45 years...
January 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29338803/socio-demographic-inequalities-in-the-clinical-characteristics-of-dengue-haemorrhagic-fever-in-the-city-of-rio-de-janeiro-brazil-2007-2008
#7
Sheila Moura Pone, Yara Hahr Marques Hökerberg, Patricia Brasil, Cecília Carmen de Araújo Nicolai, Rogério Ferrari, Raquel de Vasconcellos Carvalhaes de Oliveira
In 2007-2008, the city of Rio de Janeiro underwent an epidemiological change, with increases in the incidence in children and in severe forms of dengue. To describe the clinical profile and spatial distribution of dengue we performed an ecological study based on dengue surveillance data using the Brazilian classification (2005): dengue fever, dengue haemorrhagic fever (DHF) and dengue with complications. χ 2 test was used to describe the clinical and socio-demographic variables (P < 0.05). Spatial distribution of incidence and case-fatality was explored with thematic maps, Moran and Geary indices (P < 0...
February 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29298247/the-effect-of-early-knowledge-of-respiratory-syncytial-virus-positivity-on-medical-decision-making-and-throughput-time-within-the-pediatric-emergency-department
#8
Jessica Schnell, Lisa Schroeder, Kelly Sinclair, Lina Patel, Denise Dowd
OBJECTIVE: The aim of this study was to evaluate whether early knowledge of respiratory syncytial virus (RSV) positivity by rapid triage-based testing protocol improved emergency department (ED) throughput time and decreased ED ancillary testing and antibiotic administration. METHODS: A retrospective cohort study was performed of ED patients aged 2 to 12 months, presenting November 1 to March 31 for the years 2008-2013. Included patients presented with fever and upper respiratory tract symptoms...
January 2, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29242012/outcomes-of-immunocompetent-children-presenting-with-fever-and-neutropenia
#9
Osnat Wittmann, Ayelet Rimon, Dennis Scolnik, Miguel Glatstein
BACKGROUND: Neutropenia may alarm clinicians and prompt extensive evaluation in children with fever, even in immunocompetent patients. OBJECTIVE: Our aim was to determine outcomes in previously healthy febrile children presenting to the emergency department with severe neutropenia. METHODS: We reviewed data from infants and children aged 3-36 months with fever and severe neutropenia, defined as a peripheral neutrophil count <500 × 103/μL, at our institution between January 1, 2012 and December 31, 2015...
December 11, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29241647/safety-of-currently-licensed-hepatitis-b-surface-antigen-vaccines-in-the-united-states-vaccine-adverse-event-reporting-system-vaers-2005-2015
#10
Penina Haber, Pedro L Moro, Carmen Ng, Paige W Lewis, Beth Hibbs, Sarah F Schillie, Noele P Nelson, Rongxia Li, Brock Stewart, Maria V Cano
INTRODUCTION: Currently four recombinant hepatitis B (HepB) vaccines are in use in the United States. HepB vaccines are recommended for infants, children and adults. We assessed adverse events (AEs) following HepB vaccines reported to the Vaccine Adverse Event Reporting System (VAERS), a national spontaneous reporting system. METHODS: We searched VAERS for reports of AEs following single antigen HepB vaccine and HepB-containing vaccines (either given alone or with other vaccines), from January 2005 - December 2015...
December 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29198212/rubella-vaccination-in-india-identifying-broad-consequences-of-vaccine-introduction-and-key-knowledge-gaps
#11
A K Winter, S Pramanik, J Lessler, M Ferrari, B T Grenfell, C J E Metcalf
Rubella virus infection typically presents as a mild illness in children; however, infection during pregnancy may cause the birth of an infant with congenital rubella syndrome (CRS). As of February 2017, India began introducing rubella-containing vaccine (RCV) into the public-sector childhood vaccination programme. Low-level RCV coverage among children over several years can result in an increase in CRS incidence by increasing the average age of infection without sufficiently reducing rubella incidence. We evaluated the impact of RCV introduction on CRS incidence across India's heterogeneous demographic and epidemiological contexts...
December 4, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29198174/intracranial-complications-of-midline-nasal-dermoid-cysts
#12
Dries Opsomer, Toon Allaeys, Ann-Sofie Alderweireldt, Edward Baert, Nathalie Roche
BACKGROUND: Nasal dermoid cysts are common tumors in children. Due to anomalies in embryologic development of the nasal complex, sometimes an intracranial extension exists. When these cysts become infected they can lead to meningitis, brain abscess and death. METHODS: We report the case of a 1.5-year-old girl admitted to the paediatric intensive care unit after infection of a nasal dermoid cyst. RESULTS: The infant had a spiking fever and epileptic seizures...
December 4, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29181745/salicylate-intoxication-in-an-infant-a-case-report
#13
Rita Espírito Santo, Sara Vaz, Filipa Jalles, Leonor Boto, Francisco Abecasis
In children, the most common cause of an elevated anion gap (AG) with ketonemia, ketonuria, hyperglycemia, and glycosuria is diabetic ketoacidosis. However, when the clinical history is not clear, other causes must be considered. A 9-month-old girl was transferred to our pediatric intensive care unit (PICU) because of severe metabolic acidosis. On admission, she presented with Kussmaul breathing, tachycardia, irritability, and fever. Blood gasses revealed metabolic acidosis with superimposed respiratory alkalosis and elevated AG...
November 27, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29163934/determinants-of-integrated-management-of-childhood-illness-imci-non-severe-pneumonia-classification-and-care-in-malawi-health-facilities-analysis-of-a-national-facility-census
#14
Emily White Johansson, Humphreys Nsona, Liliana Carvajal-Aguirre, Agbessi Amouzou, Helena Hildenwall
Background: Research shows inadequate Integrated Management of Childhood Illness (IMCI)-pneumonia care in various low-income settings but evidence is largely from small-scale studies with limited evidence of patient-, provider- and facility-levels determinants of IMCI non-severe pneumonia classification and its management. Methods: The Malawi Service Provision Assessment 2013-2014 included 3149 outpatients aged 2-59 months with completed observations, interviews and re-examinations...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29162064/effect-of-exclusive-breastfeeding-on-selected-adverse-health-and-nutritional-outcomes-a-nationally-representative-study
#15
Md Nuruzzaman Khan, M Mofizul Islam
BACKGROUND: Despite growing evidence in support of exclusive breastfeeding (EBF) among infants in the first 6 months of birth, the debate over the optimal duration of EBF continues. This study examines the effect of termination of EBF during the first 2, 4 and 6 months of birth on a set of adverse health and nutritional outcomes of infants. METHODS: Three waves of Bangladesh Demographic and Health Survey data were analysed using multivariate regression. The adverse health outcomes were: an episode of diarrhea, fever or acute respiratory infection (ARI) during the 2 weeks prior to the survey...
November 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29145358/progress-in-rubella-and-congenital-rubella-syndrome-control-and-elimination-worldwide-2000-2016
#16
Gavin B Grant, Susan E Reef, Minal Patel, Jennifer K Knapp, Alya Dabbagh
Although rubella virus infection usually causes a mild fever and rash illness in children and adults, infection during pregnancy, especially during the first trimester, can result in miscarriage, fetal death, stillbirth, or infants with a constellation of congenital malformations known as congenital rubella syndrome (CRS) (1). Rubella is a leading vaccine-preventable cause of birth defects. Preventing these adverse pregnancy outcomes is the focus of rubella vaccination programs. In 2011, the World Health Organization (WHO) updated guidance on the preferred strategy for introduction of rubella-containing vaccine (RCV) into national immunization schedules and recommended an initial vaccination campaign, usually targeting children aged 9 months-14 years (1)...
November 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29145294/recurrent-tracheoesophageal-fistula-in-an-adolescent-without-persistent-symptoms-a-case-report
#17
Jun-Hong Lin, Li Deng, Xing Li
RATIONALE: Congenital esophageal atresia (EA) and tracheoesophageal fistula (TEF) ininfants have been treated well with surgery. Approximately 10% of children displayed recurrent fistula. In the present case, we reported recurrent TEF in an adolescent as a complication of EA/TEF in infancy. PATIENT CONCERNS: An infant was diagnosed with gross type C congenital EA and TEF and subsequentlyunderwent repair in early infancy, with division of the TEF and primary esophageal anastomosis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145212/does-anaemia-have-major-public-health-importance-in-children-aged-6-59-months-in-the-duggina-fanigo-district-of-wolaita-zone-southern-ethiopia
#18
Yohannes Samuel Tiku, Tefera Chane Mekonnen, Shimelash Bitew Workie, Endale Amare
BACKGROUND: Globally, a large number of children aged 6-59 months are affected by anaemia. In Ethiopia, like other developing countries, more than 40% of children under 5 years are affected by anaemia. Anaemia during infancy and childhood period is associated with poor health and impaired cognitive development, leading to reduced academic achievement and earning potential in their adult life. The aim of this research was to assess whether anaemia remained a major public health problem among children aged 6-59 months or not in Duggina Fanigo District of Wolaita Zone, South Ethiopia in 2016...
November 16, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29118655/the-burden-of-dengue-source-reduction-measures-and-serotype-patterns-in-myanmar-2011-to-2015-r2
#19
Pwint Mon Oo, Khin Thet Wai, Anthony D Harries, Hemant Deepak Shewade, Tin Oo, Aung Thi, Zaw Lin
Background: Myanmar is currently classified as a high burden dengue country in the Asian Pacific region. The Myanmar vector-borne diseases control (VBDC) program has collected data on dengue and source reduction measures since 1970, and there is a pressing need to collate, analyze, and interpret this information. The aim of this study was to describe the burden of hospital-based dengue disease, dengue control measures, and serotype patterns in Myanmar between 2011 and 2015. Methods: This was a cross-sectional study using annual records from the Dengue Fever/Dengue Hemorrhagic Fever Prevention and Control Project in Myanmar...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29100794/serotype-distribution-and-clinical-correlation-of-streptococcus-agalactiae-causing-invasive-disease-in-infants-and-children-in-taiwan
#20
Chiao-Wei Lo, Hao-Chuan Liu, Chien-Chung Lee, Chia-Ling Lin, Chyi-Liang Chen, Mei-Jy Jeng, Cheng-Hsun Chiu
BACKGROUND: Streptococcus agalactiae, or group B Streptococcus (GBS), remains to be one of the leading pathogens causing invasive infections in infants. METHODS: The clinical GBS isolates from sterile sites of patients younger than 18 years old were collected from October 1998 to December 2014 in two hospitals in Taiwan. Medical records were retrospectively reviewed. Every isolate was serotyped with a multiplex PCR assay. Multilocus sequence typing (MLST) was performed in representative isolates of different serotypes...
October 24, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
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