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https://www.readbyqxmd.com/read/28340322/immunogenicity-and-safety-of-primary-and-booster-vaccination-with-2-investigational-formulations-of-diphtheria-tetanus-and-haemophilus-influenzae-type-b-antigens-in-a-hexavalent-dtpa-hbv-ipv-hib-combination-vaccine-in-comparison-with-the-licensed-infanrix-hexa
#1
Timo Vesikari, Luis Rivera, Tiina Korhonen, Anitta Ahonen, Brigitte Cheuvart, Marjan Hezareh, Winnie Janssens, Narcisa Mesaros
Safety and immunogenicity of 2 investigational formulations of diphtheria, tetanus and Haemophilus influenzae type b antigens of the combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliomyelitis-Hib vaccine (DTPa-HBV-IPV/Hib) were evaluated in a Primary (NCT01248884) and a Booster vaccination (NCT01453998) study. In the Primary study, 721 healthy infants (randomized 1:1:1) received 3 doses of DTPa-HBV-IPV/Hib formulation A (DATAPa-HBV-IPV/Hib), or B (DBTBPa-HBV-IPV/Hib) or the licensed DTPa-HBV-IPV/Hib vaccine (Infanrix hexa, GSK; control group) at 2, 3, 4 months of age...
March 24, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28337078/comparison-of-the-efficacy-and-safety-of-2-acetaminophen-dosing-regimens-in-febrile-infants-and-children-a-report-on-3-legacy-studies
#2
Anthony R Temple, Brenda Zimmerman, Cathy Gelotte, Edwin K Kuffner
OBJECTIVE: Compare efficacy and safety of 10 to 15 mg/kg with 20 to 30 mg/kg acetaminophen in febrile children 6 months to ≤ 11 years from 3 double-blind, randomized, single or multiple dose studies. METHODS: Doses were compared on sum of the temperature differences (SUMDIFF), maximum temperature difference (MAXDIFF), temperature differences at each time point, and dose by time interactions. Alanine aminotransferase (ALT) was evaluated in the 72-hour duration study...
January 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28328604/retropharyngeal-abscess-presenting-with-sleep-apnea-syndrome
#3
Hasan Emre Koçak, Mehmet Nurettin Kiral, Harun Acipayam, Mustafa Suphi Elbistanli, Fatma Tülin Kayhan
Retropharyngeal abscess (RPA) is the second most common deep neck space infection after peritonsiller abscess in pediatric population. Major signs and symptoms on physical examination include fever, hypersalivation, odynophagia, reduced oral intake, sore throat, swelling on the neck, torticollis, limitation in neck mobility, and voice changes. In this paper, the authors present a case of RPA with unusual and interesting presenting symptoms in a 10-month-old infant that exhibit new-onset and worsening snoring and sleep apnea...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28321310/neonatal-cholestasis-mimicking-biliary-atresia-could-it-be-urinary-tract-infection
#4
Noella Maria Delia Pereira, Ira Shah
Cholestasis can occur in newborns due to infections. However, the manifestations of the underlying infections usually dominate the presentation. We present a 2-month-old infant who presented with jaundice and no fever or signs of systemic illness. Liver biopsy was suggestive of cholangitis. He was subsequently detected to have urinary tract infection with Klebsiella pneumoniae. The child was treated with appropriate antibiotics for 2 weeks following which the cholestasis resolved. Thus, neonatal cholestasis due to infections can also occur in the post-neonatal period without clinical manifestations of an underlying infection...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28318359/zika-virus-and-eye
#5
Rupesh Agrawal, Hnin Hnin Oo, Praveen Kumar Balne, Lisa Ng, Louis Tong, Yee Sin Leo
Zika virus (ZIKV), a mosquito-borne flavivirus, is the latest global health concern. Transmission is mainly via Aedes mosquitoes and the infection can be diagnosed on molecular or serologic testings. It typically causes a mild self-remitting illness of low-grade fever, maculopapular rash, and myalgia, but when severe, it is associated with neurological deficits and congenital structural defects. Ocular manifestations are usually mild like nonpurulent conjunctivitis in adults, though it may be linked to uveitis, maculopathy, and hypertensive iridocyclitis...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28306338/the-epidemiology-of-childhood-salmonella-infections-in-alberta-canada
#6
Kate E Faulder, Kimberley Simmonds, Joan L Robinson
OBJECTIVES: The objectives were to describe the incidence, demographics, laboratory findings, and suspected sources of childhood Salmonella infections in Alberta, Canada, with a focus on preventable cases. METHODS: Data from Notifiable Disease Reports for children with nontyphoidal salmonellosis (NTS) or typhoid/paratyphoid fever from 2007 through 2015 were analyzed. RESULTS: NTS was detected from 2285 children. Bacteremia was documented in 55 cases (2...
March 17, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28301056/age-at-onset-and-persistence-of-eczema-are-related-to-subsequent-risk-of-asthma-and-hay-fever-from-birth-to-18-years-of-age
#7
Adrian J Lowe, Bianca Angelica, John Su, Caroline J Lodge, David J Hill, Bircan Erbas, Catherine M Bennett, Lyle C Gurrin, Christine Axelrad, Michael J Abramson, Katrina J Allen, Shyamali Dharmage
BACKGROUND: Few studies have simultaneously addressed the importance of age of onset and persistence of eczema for the subsequent development of asthma and hay fever, particularly into early adulthood. METHODS: A high risk birth cohort was recruited comprising 620 infants, who were then followed up frequently until two years of age, annually from age 3 to 7, then at 12 and 18 years, to document any episodes of eczema, current asthma and hay fever. The generalised estimation equation technique was used to examine asthma and hay fever outcomes at 6 (n=325), 12 (n=248) and 18 (n=240) years, when there was consistency of associations across the follow-ups...
March 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28299723/mold-and-human-health-a-reality-check
#8
REVIEW
Andrea T Borchers, Christopher Chang, M Eric Gershwin
There are possibly millions of mold species on earth. The vast majority of these mold spores live in harmony with humans, rarely causing disease. The rare species that does cause disease does so by triggering allergies or asthma, or may be involved in hypersensitivity diseases such as allergic bronchopulmonary aspergillosis or allergic fungal sinusitis. Other hypersensitivity diseases include those related to occupational or domiciliary exposures to certain mold species, as in the case of Pigeon Breeder's disease, Farmer's lung, or humidifier fever...
March 16, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28288233/-dress-syndrome-in-paediatrics-clinical-case
#9
Marcos Silva-Feistner, Elena Ortiz, María Jesús Rojas-Lechuga, Daniel Muñoz
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially life-threatening, drug-induced hypersensitivity reaction that includes skin eruption, haematological abnormalities, lymphadenopathy, and internal organ involvement. OBJECTIVE: Presenting a rare condition in children, to facilitate a rapid diagnostic suspicion and recognition by doctors. CASE REPORT: An 9 months old infant admitted due to a severe viral pneumonia, managed with non-invasive ventilation and ceftriaxone...
February 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28277411/testing-for-urinary-tract-infection-in-the-influenza-respiratory-syncytial-virus-positive-febrile-infant-aged-2-to-12-months
#10
Anna Kathleen Schlechter Salinas, David S Hains, Tamekia Jones, Camden Harrell, Mark Meredith
OBJECTIVE: Infants 12 months or younger with influenza and respiratory syncytial virus (RSV) commonly present to the emergency department (ED) with fever. Previous publications have recommended that these patients have a urinalysis and urine culture performed. We aimed to assess the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the ED. We also examined whether the 2011 American Academy of Pediatrics (AAP) UTI clinical practice guidelines could be used to identify patients at lower risk of UTI...
March 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28274237/comparison-of-two-european-paediatric-emergency-departments-does-primary-care-organisation-influence-emergency-attendance
#11
F Poropat, P Heinz, E Barbi, A Ventura
BACKROUND: To compare paediatric Emergency Department (ED) attendances and admission outcomes in two European hospitals with different paediatric primary care set-up. METHODS: This is a retrospective prevalence study comparing all paediatric ED attendances during calendar years 2013 in two EDs with similar catchment area: one in Italy (Trieste) where paediatric primary care is provided by office paediatricians, the other, in the UK (Cambridge), where paediatric primary care is provided by general practitioners...
March 8, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28272068/rare-disease-heralded-by-pulmonary-manifestations-avoiding-pitfalls-of-an-asthma-label
#12
S Bajaj, M Muranjan, S Karande, D Prabhat
Pulmonary manifestations are seldom recognized as symptoms of storage disorders. The report describes the diagnostic journey in a 30-month-old male infant, born of a third-degree consanguineous marriage referred to our institute as severe persistent asthma. History revealed that the child had progressively worsening breathlessness and persistent dry cough not associated with fever but accompanied by weight loss. On physical examination, there was growth failure, respiratory distress, clubbing, hepatosplenomegaly, and occasional rhonchi...
March 3, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28264648/a-phase-i-dose-escalation-study-of-selumetinib-in-combination-with-docetaxel-or-dacarbazine-in-patients-with-advanced-solid-tumors
#13
Patricia M LoRusso, Jeffrey R Infante, Kevin B Kim, Howard A Burris, Gregory Curt, Ugochi Emeribe, Delyth Clemett, Helen K Tomkinson, Roger B Cohen
BACKGROUND: The RAS/RAF/MEK/ERK pathway is constitutively activated in many cancers. Selumetinib (AZD6244, ARRY-142886) is an oral, potent and highly selective, allosteric MEK1/2 inhibitor with a short half-life that has shown clinical activity as monotherapy in phase I and II studies of advanced cancer. Preclinical data suggest that selumetinib may enhance the activity of chemotherapeutic agents. We assessed the safety, tolerability, and pharmacokinetics (PK) of selumetinib (AZD6244, ARRY-142886) in combination with docetaxel or dacarbazine in patients with advanced solid tumors...
March 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28263087/protein-losing-enteropathy-in-an-infant-with-rotavirus-infection
#14
Adriana Parisi, Alessandro Cafarotti, Roberta Salvatore, Piernicola Pelliccia, Luciana Breda, Francesco Chiarelli
Protein-losing enteropathy (PLE) is a rare gastro-intestinal complication characterised by intestinal loss of proteins with consequent hypoproteinaemia and generalised oedema. Rotavirus infection associated with PLE in children has rarely been reported. A 6-month-old girl presented with diarrhoea, fever and generalised oedema. Total serum proteins were 34 g/L (61-79) and plasma albumin 16.8 g/L (40-50), serum sodium was 126 mmol/L and there was mild metabolic alkalosis (pH 7.46). Stool for alpha-1 antitrypsin was >1...
March 6, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28262382/fever-and-malaise-in-an-infant
#15
David S Young, Emily S Miller, Kriti Bhatia
No abstract text is available yet for this article.
March 2, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28262330/a-randomized-study-of-fever-prophylaxis-and-the-immunogenicity-of-routine-pediatric-vaccinations
#16
Jacek Wysocki, Kimberly J Center, Jerzy Brzostek, Ewa Majda-Stanislawska, Henryk Szymanski, Leszek Szenborn, Hanna Czajka, Barbara Hasiec, Jerzy Dziduch, Teresa Jackowska, Anita Witor, Elżbieta Kopińska, Ryszard Konior, Peter C Giardina, Vani Sundaraiyer, Scott Patterson, William C Gruber, Daniel A Scott, Alejandra Gurtman
OBJECTIVE: Prophylactic antipyretic use during pediatric vaccination is common. This study assessed whether paracetamol or ibuprofen prophylaxis interfere with immune responses to the 13-valent pneumococcal conjugate vaccine (PCV13) given concomitantly with the combined DTaP/HBV/IPV/Hib vaccine. METHODS: Subjects received prophylactic paracetamol or ibuprofen at 0, 6-8, and 12-16 h after vaccination, or 6-8 and 12-16 h after vaccination at 2, 3, 4, and 12months of age...
April 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28237252/effect-of-ebola-virus-disease-on-maternal-and-child-health-services-in-guinea-a-retrospective-observational-cohort-study
#17
Alexandre Delamou, Alison M El Ayadi, Sidikiba Sidibe, Therese Delvaux, Bienvenu S Camara, Sah D Sandouno, Abdoul H Beavogui, Georges W Rutherford, Junko Okumura, Wei-Hong Zhang, Vincent De Brouwere
BACKGROUND: The 2014 west African epidemic of Ebola virus disease posed a major threat to the health systems of the countries affected. We sought to quantify the consequences of Ebola virus disease on maternal and child health services in the highly-affected Forest region of Guinea. METHODS: We did a retrospective, observational cohort study of women and children attending public health facilities for antenatal care, institutional delivery, and immunisation services in six of seven health districts in the Forest region (Beyla, Guéckédou, Kissidougou, Lola, Macenta, and N'Zérékoré)...
April 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28225335/integrating-tuberculosis-screening-in-kenyan-prevention-of-mother-to-child-transmission-programs
#18
L M Cranmer, A Langat, K Ronen, C J McGrath, S LaCourse, J Pintye, B Odeny, B Singa, A Katana, L Nganga, J Kinuthia, G John-Stewart
BACKGROUND: Tuberculosis (TB) screening in Prevention of Mother-To-Child Transmission (PMTCT) programs is important to improve TB detection, prevention and treatment. METHODS: As part of a national PMTCT program evaluation, mother-infant pairs attending 6-week and 9-month immunization visits were enrolled at 141 maternal and child health clinics throughout Kenya. Clinics were selected using population-proportion-to-size sampling with oversampling in a high human immunodeficiency virus (HIV) prevalence region...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28202706/clinical-and-genetic-factors-predicting-dravet-syndrome-in-infants-with-scn1a-mutations
#19
Valentina Cetica, Sara Chiari, Davide Mei, Elena Parrini, Laura Grisotto, Carla Marini, Daniela Pucatti, Annarita Ferrari, Federico Sicca, Nicola Specchio, Marina Trivisano, Domenica Battaglia, Ilaria Contaldo, Nelia Zamponi, Cristina Petrelli, Tiziana Granata, Francesca Ragona, Giuliano Avanzini, Renzo Guerrini
OBJECTIVE: To explore the prognostic value of initial clinical and mutational findings in infants with SCN1A mutations. METHODS: Combining sex, age/fever at first seizure, family history of epilepsy, EEG, and mutation type, we analyzed the accuracy of significant associations in predicting Dravet syndrome vs milder outcomes in 182 mutation carriers ascertained after seizure onset. To assess the diagnostic accuracy of all parameters, we calculated sensitivity, specificity, receiver operating characteristic (ROC) curves, diagnostic odds ratios, and positive and negative predictive values and the accuracy of combined information...
March 14, 2017: Neurology
https://www.readbyqxmd.com/read/28198193/association-between-dehydration-and-fever-during-the-first-week-of-life
#20
Ariane Boutin, Ana Carceller, Marie Pier Desjardins, Marisol Sanchez, Jocelyn Gravel
BACKGROUND: Trying to differentiate serious bacterial infection (SBI) from a self-limiting illness in febrile infants seen in the pediatric emergency department (PED) is a significant challenge. The aim of the study was to determine the prevalence of dehydration and its relationship to SBI in febrile full-term newborns under 1 week of age seen in a PED. METHODS: A retrospective observational study was carried out on all children younger than 8 days of age with fever who presented to a single, tertiary care, PED from January 2009 to April 2014...
February 1, 2017: Clinical Pediatrics
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