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Clostridium butyricum

Boo-Yong Sim, Hak-Joo Choi, Min-Goo Kim, Dong-Gu Jeong, Don-Gil Lee, Jong-Min Yoon, Dae-Jung Kang, Soobong Park, Joong-Gu Ji, In-Hwan Joo, Dong-Hee Kim
Osteoarthritis is a disease that affects the articular cartilage and osseous tissue, and can be worsened by aging, overweight status, and post-traumatic arthritis. The present study aimed to evaluate the effect of ID-CBT5101 (tyndallized Clostridium butyricum ) on bone metabolism and the inflammatory response in a monosodium iodoacetate-induced rat model of osteoarthritis. ID-CBT5101 was administered orally at doses of 108 CFU/day or 1010 CFU/day for 2 weeks before direct injection of monosodium iodoacetate (3 mg/50 µL of 0...
May 11, 2018: Journal of Microbiology and Biotechnology
Francisco A Uzal, Mauricio A Navarro, J Jihong Li, John C Freedman, Archana Shrestha, Bruce A McClane
Several enteric clostridial diseases can affect humans and animals. Of these, the enteric infections caused by Clostridium perfringens and Clostridium difficile are amongst the most prevalent and they are reviewed here. C. perfringens type A strains encoding alpha toxin (CPA) are frequently associated with enteric disease of many animal mammalian species, but their role in these diseased mammals remains to be clarified. C. perfringens type B encoding CPA, beta (CPB) and epsilon (ETX) toxins causes necro-hemorrhagic enteritis, mostly in sheep, and these strains have been recently suggested to be involved in multiple sclerosis in humans, although evidence of this involvement is lacking...
June 5, 2018: Anaerobe
Chhaiden Heak, Peerapol Sukon, Pairat Sornplang
Objective: This meta-analysis was conducted to evaluate the overall effect of direct-fed microbial (DFM) or probiotic supplementation on the log concentrations of culturable gut microbiota in broiler chickens. Methods: Relevant studies were collected from PubMed, SCOPUS, Poultry Science Journal, and Google Scholar. The studies included controlled trials using DFM supplementation in broiler chickens and reporting log concentrations of the culturable gut microbiota...
May 31, 2018: Asian-Australasian Journal of Animal Sciences
Yafei Duan, Jiasong Zhang, Jianhua Huang, Shigui Jiang
The present study investigated the effects of the dietary probiotic Clostridium butyricum (CB) on the growth, intestine digestive enzyme activity, antioxidant capacity and resistance to nitrite stress, and body composition of Penaeus monodon. For 56 days, shrimps were fed diets containing different levels of C. butyricum (1 × 109  CFU g-1 ), 0% (control), 0.5% (CB1), 1.0% (CB2), and 2.0% (CB3), as treatment groups, followed by an acute nitrite stress test for 48 h. The results indicated that dietary supplementation of C...
June 1, 2018: Probiotics and Antimicrobial Proteins
Hai-Hua Li, Yu-Peng Li, Qi Zhu, Jia-Yun Qiao, Wen-Jie Wang
AIMS: The objective of this study was twofold: (i) to examine the effect of Clostridium butyricum on intestinal barrier function and (ii) to elucidate the mechanisms involved in enhanced intestinal barrier function. METHODS AND RESULTS: Forty-eight weaned piglets were assigned randomly to either a basal diet or a C. butyricum-supplemented diet. On day 15, all pigs were orally challenged with enterotoxigenic Escherichia coli (ETEC) K88 or saline. C. butyricum decreased serum diamine oxidase activity and D-lactic acid concentration, as well as increased intestinal tight junction proteins (ZO-1, claudin-3 and occludin) expression in ETEC K88-infected pigs...
May 31, 2018: Journal of Applied Microbiology
Xiaoxue Xia, Jiang Chen, Jiayun Xia, Bin Wang, Hua Liu, Ling Yang, Ying Wang, Zongxin Ling
Objective This study was performed to investigate the role of probiotics ( Clostridium butyricum combined with Bifidobacterium infantis) in the treatment of minimal hepatic encephalopathy (MHE) in patients with hepatitis B virus (HBV)-induced liver cirrhosis. Methods Sixty-seven consecutive patients with HBV-induced cirrhosis without overt hepatic encephalopathy were screened using the number connection test and digit symbol test. The patients were randomized to receive probiotics (n = 30) or no probiotics (n = 37) for 3 months...
January 1, 2018: Journal of International Medical Research
Miaomiao Yang, Junhua Yun, Huanhuan Zhang, Tinashe A Magocha, Hossain Zabed, Yanbo Xue, Ernest Fokum, Wenjing Sun, Xianghui Qi
1,3-Propanediol (1,3-PD) is one of the most important chemicals widely used as monomers for synthesis of some commercially valuable products, including cosmetics, foods, lubricants and medicines. Although 1,3-PD can be synthesized both chemically and biosynthetically, the latter offers more merits over chemical approach as it is economically viable, environmentally friendly and easy to carry out. The biosynthesis of 1,3-PD can be done by transforming glycerol or other similar substrates using some bacteria, such as Clostridium butyricum and Klebsiella pneumoniae ...
March 2018: Food Technology and Biotechnology
Yanhan Liu, Yiyu Li, Xiancheng Feng, Zhong Wang, Zhaofei Xia
The aim of this study was to investigate the effects of Clostridium butyricum (C. butyricum) on the performance, serum lipid metabolism, muscle morphology, meat quality, and fatty acid profiles of Peking ducks. A total of 1,500 Peking ducks were randomly divided into five groups with five replicates and were fed a non-antibiotic basal diet (Control) or a basal diet supplemented with either 200, 400, or 600 mg/kg of C. butyricum (2.0 × 109 CFU/g) or 150 mg of aureomycin/kg for 42 d. Compared with the control group, supplementation with C...
May 14, 2018: Poultry Science
Jong-Hun Park, Young-Bo Sim, Gopalakrishnan Kumar, Parthiban Anburajan, Jeong-Hoon Park, Hee-Deung Park, Sang-Hyoun Kim
This study investigated the kinetic parameters of high-rate continuous performance and biofilm layer formation in a H2 -producing dynamic membrane bioreactor, composed of a continuously stirred tank reactor along with an external module containing polyester mesh with a pore size of 100 µm. A maximum H2 production rate of 48.9 L/L-day and hydrogen yield of 2.8 mol/mol glucoseadded were attained at a hydraulic retention time of 3 h. The maximum specific growth rate and Monod constant were estimated as 14...
August 2018: Bioresource Technology
Jie Zhang, Xiyue Chen, Ping Liu, Jinbiao Zhao, Jian Sun, Wenyi Guan, Lee J Johnston, Crystal L Levesque, Peixin Fan, Ting He, Guolong Zhang, Xi Ma
Clostridium butyricum is known as a butyrate producer and a regulator of gut health, but whether it exerts a beneficial effect as a dietary supplement via modulating the intestinal microbiota remains elusive. This study investigated the impact of C. butyricum on the fecal microbiota composition and their metabolites 14 and 28 days after weaning with 10 g/kg dietary supplementation of C. butyricum. Dynamic changes of microbial compositions showed dramatically increasing Selenomonadales and decreasing Clostridiales on days 14 and 28...
May 23, 2018: Journal of Agricultural and Food Chemistry
Yukio Sato, Dai Kujirai, Katsura Emoto, Toshiaki Yagami, Taketo Yamada, Manabu Izumi, Masaki Ano, Kenichi Kase, Kenji Kobayashi
Case: Necrotizing enterocolitis (NEC) caused by Clostridium butyricum is common in neonates; however, a case of NEC in adults has not been previously reported. An 84-year-old Japanese man developed C. butyricum -related NEC during hospitalization for treatment of stab wounds to the left side of the neck and lower abdomen, without organ damage, and concomitant pneumonia. Outcome: The patient developed acute onset of emesis accompanied by shock during his admission; partial resection of the small intestine was carried out due to necrosis...
April 2018: Acute Medicine & Surgery
Motomichi Takahashi, Elinor McCartney, Anne Knox, Maria Francesch, Kentaro Oka, Kaoruko Wada, Marie Ideno, Koji Uno, Krzysztof Kozłowski, Jan Jankowski, Marta I Gracia, Joaquin Morales, Spyridon K Kritas, Enric Esteve-Garcia, Shigeru Kamiya
The objective of this study was to assess the effects of a probiotic strain Clostridium butyricumMIYAIRI 588 (CBM588) on broiler and weaned piglet health and zootechnical performance. Five field studies were carried out in broilers and five in weaned piglets under European feed additive guidelines. Each study followed a randomized blocked design with two treatments: Control (basal diet) and CBM588 supplemented groups. The zootechnical performance parameters selected were body weight, daily gain, feed intake and feed efficiency (feed:gain)...
March 30, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
Tiago Pinto, Luísa Gouveia, Joana Ortigueira, Ganesh D Saratale, Patrícia Moura
In this work, hydrogen (H2 ) was produced through the fermentation of Spirogyra sp. biomass by Clostridium butyricum DSM 10702. Macronutrient stress was applied to increase the carbohydrate content in Spirogyra, and a 36% (w/w) accumulation of carbohydrates was reached by nitrogen depletion. The use of wet microalga as fermentable substrate was compared with physically and chemically treated biomass for increased carbohydrate solubilisation. The combination of drying, bead beating and mild acid hydrolysis produced a saccharification yield of 90...
March 23, 2018: Journal of Bioscience and Bioengineering
Waraporn Apiwatanapiwat, Pilanee Vaithanomsat, Warunee Thanapase, Khanok Ratanakhanokchai, Akihiko Kosugi
Lignocellulosic biomass as co-substrate enhances the 1,3-propanediol (1,3-PD) production of anaerobic fermenters by increasing their conversion yield from glycerol. To improve 1,3-propanediol (1,3-PD) production by this efficient approach, Clostridium butyricum I5-42 was supplemented with lignocellulosic biomasses (starch free fiber (CPF) from cassava pulp and xylan) as co-substrates. The 1,3-PD production and growth of C. butyricum were considerably higher in glycerol plus CPF and xylan than in glycerol alone, whereas another major polysaccharide (cellulose co-substrate) failed to improve the 1,3-PD production...
March 10, 2018: Journal of Bioscience and Bioengineering
Xin Kong, Shuyao Yu, Wen Fang, Jianguo Liu, Huan Li
The impacts of ZVI on microbial community diversity in an anaerobic assay with high organic loading were investigated. The relative abundance of bacteria, archaea, and the functional methyl coenzyme-M reductase (mcrA) gene were investigated using high-throughput sequencing, and variations in their quantity were determined by qPCR. The results showed that ZVI significantly increased both the relative abundance and quantity of Methanobacteriales and Methanosarcinales during hydrogenotrophic and acetoclastic methanogenesis...
June 2018: Bioresource Technology
Lei-Min Yu, Ke-Jia Zhao, Shuang-Shuang Wang, Xi Wang, Bin Lu
AIM: To study the role of microbial metabolites in the modulation of biochemical and physiological processes in irritable bowel syndrome (IBS). METHODS: In the current study, using a metabolomic approach, we analyzed the key metabolites differentially excreted in the feces of control mice and mice with IBS, with or without Clostridium butyricum (C. butyricum) treatment. C57BL/6 mice were divided into control, IBS, and IBS + C. butyricum groups. In the IBS and IBS + C...
February 28, 2018: World Journal of Gastroenterology: WJG
Erin M Nawrocki, Marite Bradshaw, Eric A Johnson
Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids. Prior work in our laboratory demonstrated that Group I BoNT plasmids were mobilized to C. botulinum recipient strains containing the Tn916 transposon. Here, we show that Tn916 is nonessential for plasmid transfer. Relying on an auxotrophic donor phenotype and a plasmid-borne selectable marker, we observed the transfer of pCLJ, a 270 kb plasmid harboring two bont genes, from its host strain to various clostridia...
February 15, 2018: Scientific Reports
Yi-Yuan Sun, Ming Li, Yue-Yue Li, Li-Xiang Li, Wen-Zhe Zhai, Peng Wang, Xiao-Xiao Yang, Xiang Gu, Li-Jin Song, Zhen Li, Xiu-Li Zuo, Yan-Qing Li
Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients. Clostridium butyricum (CB) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of CB in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of CB in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given CB or placebo for 4 weeks...
February 14, 2018: Scientific Reports
Rui-Xue Miao, Xin-Xin Zhu, Chao-Min Wan, Zhi-Ling Wang, Yang Wen, Yi-Yuan Li
The objective of the present study was to examine whether Clostridium butyricum supplementation has a role in the regulation of the intestinal flora and the development of the immune system of neonatal mice. A total of 30 pregnant BALB/c mice, including their offspring, were randomly divided into three groups: In the maternal intervention group (Ba), maternal mice were treated with Clostridium butyricum from birth until weaning at postnatal day 21 (PD21) followed by administration of saline to the offspring at PD21-28; in the offspring intervention group (Ab), breast-feeding maternal mice were supplemented with saline and offspring were directly supplemented with Clostridium butyricum from PD21-28; in the both maternal and offspring intervention group (Bb), both maternal mice and offspring were supplemented with Clostridium butyricum at PD 0-21 and at PD21-28...
January 2018: Experimental and Therapeutic Medicine
Fernando L L Leite, Randall S Singer, Tonya Ward, Connie J Gebhart, Richard E Isaacson
Salmonella enterica serovar Typhimurium continues to be a major cause of foodborne illness worldwide and pork can serve as a source of infection. Co-infection of S. enterica with Lawsonia intracellularis, a common intestinal pathogen of swine, has been found as risk factor for increased S. enterica shedding. The objective of this study was to investigate if vaccination against L. intracellularis could lead to decreased S. Typhimurium shedding. To test this hypothesis, pigs were challenged with either S. Typhimurium or S...
February 12, 2018: Scientific Reports
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