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Mana Tsukada, Hong Sheng, Toshiaki Kamachi, Yoshimi Niwano
Wine lees, a major waste product of winemaking, is a rich source of polyphenolic compounds. LED-light irradiation at 400-nm elicited microbicidal activity of aqueous extract from wine lees (WLE) against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, in addition to reactive oxygen species (ROS) formation, including hydroxyl radical (·OH) and hydrogen peroxide (H2O2). Although treatment for 20 min of photoirradiation alone exerted bactericidal activity with a 2- to 3-log reduction, photoirradiated WLE for 20 min achieved a 5-log or greater reduction in viable S...
July 2016: Journal of Food Science and Technology
Stephen P Lownie, David M Pelz, Manas Sharma, Sachin K Pandey, Melfort R Boulton, Donald H Lee
No abstract text is available yet for this article.
November 2016: Neurosurgery
Abhijit Mal, Masthanvali Sayyad, Imtiyaz Ahmad Wani, Manas K Ghorai
A highly enantioselective synthetic route to hexahydropyrrolo[2,3-b]indoles via Lewis acid-catalyzed SN2-type ring opening of activated aziridines with indoles having substitutions at 3- and other positions followed by cyclization in a domino fashion has been developed. Hexahydropyrrolo[2,3-b]indoles have been detosylated in the same pot to afford the corresponding products with free NH group in excellent yields (up to 95%) and enantioselectivity (up to >99%).
October 19, 2016: Journal of Organic Chemistry
Ana Belén Mañas-Martínez, Alicia Aragoneses-Calvo, Ana Matei, Sylvie Ojeda-Rodríguez, Pilar García-Durruti
No abstract text is available yet for this article.
October 14, 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Kayo Sugimoto, Soo Ki Kim, Soo Ryang Kim, Mana Kobayashi, Airi Kato, Eri Morimoto, Susumu Imoto, Chi Wan Kim, Yasuhito Tanaka, Masatoshi Kudo, Yoshihiko Yano, Yoshitake Hayashi
OBJECTIVES: The efficacy of sofosbuvir plus ribavirin (RBV) treatment for hepatitis C virus (HCV) genotype 2 focusing on virological response was compared with that of pegylated interferon (peg-IFN) plus RBV treatment. Safety of the former focusing on the decline in hemoglobin levels was compared with that of the latter and assessed in terms of age and inosine triphosphatase (ITPA). METHODS: Patients (n = 17) receiving sofosbuvir plus RBV and those (n = 24) receiving peg-IFN plus RBV diagnosed with chronic HCV genotype 2 were enrolled in this study, and the efficacy and safety of both treatments were assessed...
2016: Digestive Diseases
Kelsey Chinnadurai, Lindy Fenlason, Brian Bridges, Mana Espahbodi, Sivakumar Chinnadurai, Jane Blood-Siegfried
BACKGROUND: Ventilator-associated pneumonia (VAP) is a common nosocomial infection in pediatric intensive care units (ICUs). Ventilator-associated pneumonia protocols decrease the incidence of VAP; however, many components of these protocols are not feasible in all settings. This study was done in a large pediatric hospital in Nicaragua. OBJECTIVE: The aim of this study is to implement a sustainable evidence-based VAP protocol, in a different culture, for the purpose of decreasing VAP rates...
November 2016: Dimensions of Critical Care Nursing: DCCN
Xiaoqing Liu, Marie Haddou, Isabelle Grillo, Zohra Mana, Jean-Paul Chapel, Christophe Schatz
Polyelectrolyte complexes (PECs) between poly(acrylic acid) (PAA) and poly(diallyldimethylammonium chloride) (PDADMAC), a model system forming coacervate particles via electrostatic interaction at pH 10, were prepared by a stopped-flow (SF) fast mixing technique at different mixing charge ratios (z) and ionic strengths. Both PEC final morphologies prepared by either SF or manual one-shot mixing are similar at bench time. In situ light scattering combined with the SF technique pointed-out, however, the presence of three distinct early stage kinetic behaviors in the formation of PECs...
October 17, 2016: Soft Matter
Hitomi Hoshino, Makoto Ohta, Makoto Ito, Kenji Uchimura, Yasuhiro Sakai, Takeshi Uehara, Shulin Low, Mana Fukushima, Motohiro Kobayashi
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver neoplasm, followed by hepatocellular carcinoma. ICC can be further subclassified as (i) perihilar and (ii) peripheral types, the latter histologically resembling small-sized intrahepatic bile ducts, such as interlobular bile ducts, cholangioles/ductules and the canals of Hering. Cholangiolocellular carcinoma (CoCC), now classified by the World Health Organization as a subtype of combined hepatocellular-cholangiocarcinoma, is currently regarded as a subtype of peripheral-type ICC...
October 17, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
Manas Panigrahi, Manoranjitha Kumari, Sudhindra Vooturi
BACKGROUND: Keeping the operating field clean and visible is an important technique in neurosurgery. Continuous irrigation-suction (IS) of the surgical field is currently often done using devices available that are expensive and demand technical proficiency. We report a simple method of continuous ISusing widely available central venous catheter and controlled suction cannula. METHODS: We used a controlled suction cannula attached to a central suction system. Single lumen central venous catheter is passed through the key hole of a controlled suction cannula, which is connected to a continuous irrigation system...
October 12, 2016: World Neurosurgery
Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Jun Aida, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita
AIM: Social capital has been considered an important factor to affect mental-health outcomes such as psychological distress in post-disaster settings. Although disaster-related house-condition and displacement could affect both social capital and psychological distress, limited studies have investigated interactions. This study aimed to examine the association between social capital and psychological distress taking into consideration the interaction of disaster-related house-condition after the Great East Japan Earthquake of 2011...
October 15, 2016: Psychiatry and Clinical Neurosciences
Kazuki Okamoto, Shizu Hirata-Tsuchiya, Chiaki Kitamura, Kazuki Omoteyama, Toshiyuki Sato, Mitsumi Arito, Manae S Kurokawa, Naoya Suematsu, Tomohiro Kato
Nuclear factor-κB (NF-κB) is the most potent pro-inflammatory transactivator, and an inhibitor of NF-κB is a good anti-inflammatory drug. Glucocorticoids (GCs) are the strongest and the most frequently used anti-inflammatory drugs. GCs-bound glucocorticoid receptor (GR) inhibits the transcriptional activity of NF-κB, and thereby suppresses a broad range of inflammatory processes. Concurrently, in whole body out side of inflammation area, GR exerts a lot of hormone action, which results in severe side effects...
October 14, 2016: Endocrinology
Kumar Abhishek, Abul Hasan Sardar, Sushmita Das, Ashish Kumar, Ayan Kumar Ghosh, Ruby Singh, Savita Saini, Abhishek Mandal, Sudha Verma, Ajay Kumar, Bidyut Purkait, Manas Ranjan Dikhit, Pradeep Das
Leishmania donovani transformation to amastigote from promastigote during mammalian host infection; displays the immense adaptability of the parasite to survive under stress. Induction of translation initiation factor 2-alpha (eIF2α) phosphorylation by stress specific eIF2α kinases is the basic stress perceiving signal in eukaryotes to counter stress. Here, we demonstrate that elevated temperature and acidic pH; induces phosphorylation of Leishmania donovani eIF2α (LdeIF2α). The in-vitro inhibition experiments suggest interference of LdeIF2α phosphorylation under elevated temperature and acidic pH debilitates parasite differentiation and reduces parasite viability (P< 0...
October 10, 2016: Molecular and Cellular Biology
Rudra Prasad Roy, Kaushik Ghosh, Manas Ghosh, Amitava Acharyya, Ambarish Bhattacharya, Mrinal Pal, Sisir Chakraborty, Nilanjan Sengupta
BACKGROUND: Long-term therapy with metformin was shown to decrease the Vitamin B12 level and manifested as peripheral neuropathy. AIM: The aim of this study is to define the prevalence of Vitamin B12 deficiency in early Type 2 diabetic patients (duration ≤5 years or drug treatment ≤3 years) and the relationship among metformin exposure and levels of cobalamin (Cbl), folic acid, and homocysteine (Hcy) with severity of peripheral neuropathy. METHODOLOGY: This is a cross-sectional study involving randomly selected ninety patients (male 56, female 34) between age groups of 35 and 70 years, comparing those who had received >6 months of metformin (Group A) (n = 35) with those without metformin (Group B) (n = 35) and patients taking metformin with other oral hypoglycemic agent (Group C) (n = 20)...
September 2016: Indian Journal of Endocrinology and Metabolism
P Ferro, R Ventura, C Pérez-Mañá, M Farré, J Segura
Since the appearance of recombinant human growth hormone (rhGH) in the 80's, its expansion and acquisition through the black market has increased, so the detection of its abuse continues to be a challenge at present. New biomarkers that are more reliable and sensitive, allowing a larger detection window, are still needed. In this line, Fibronectin 1 (FN1) has been proposed as potential genetic and protein biomarker of rhGH abuse in peripheral blood lymphocytes, serum and plasma. However, logistic problems associated with current blood collection in sports drug testing points towards potential new alternative matrices that could be good candidates to be evaluated...
October 7, 2016: Drug Testing and Analysis
Shih-Pin Huang, I-Shiung Chen, Nian-Hong Jang-Liaw, Kwang-Tsao Shao, Mana M N Yung
The Mugilogobius group consists of brackish water gobionellines widely distributed in the Indo-West Pacific region. Complete mitochondrial genome and morphological evidence was collected to estimate their phylogenetic relationship and taxonomic status. A total of 11 genera were sampled, including Brachygobius, Calamiana, Hemigobius, Mugilogobius, Pandaka, Pseudogobiopsis, Pseudogobius, Redigobius, Rhinogobius, Stigmatogobius, and Wuhanlinigobius, five of which were sequenced for the first time. A morphological phylogenetic tree was also reconstructed based on 35 characters...
October 2016: Zoological Science
Suman Kumar Tripathy, Umasankar De, Niranjan Dehury, Paltan Laha, Manas Kumar Panda, Hyung Sik Kim, Srikanta Patra
Six mononuclear Ir complexes (1-6) using polypyridyl-pyrazine based ligands (L1 and L2) and {[cp*IrCl(μ-Cl)]2 and [(ppy)2Ir(μ-Cl)]2} precursors have been synthesised and characterised. Complexes 1-5 have shown potent anticancer activity against various human cancer cell lines (MCF-7, LNCap, Ishikawa, DU145, PC3 and SKOV3) while complex 6 is found to be inactive. Flow cytometry studies have established that cellular accumulation of the complexes lies in the order 2 > 1 > 5 > 4 > 3 > 6 which is in accordance with their observed cytotoxicity...
September 27, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Manas Kumar Mondal, Archana Tiwari, Chandan Mukherjee
Ligand H4L(O(AP/AP)) underwent ligand-centered C-O bond cleavage during a complexation reaction with Co(ii)-salt. The thus formed octahedral {Co(II)[(BQ-N-Cat)]2}(0) complex showed valence tautomerization in the solid state. While the process was triggered by the presence of lattice solvent, the nature of the solvent molecule has less effect on the process.
September 29, 2016: Chemical Communications: Chem Comm
Patrick Commins, Israel Tilahun Desta, Durga Prasad Karothu, Manas K Panda, Panče Naumov
When exposed to external stimuli such as heat or light, certain single crystals can acquire momentum and undergo motion. On a molecular scale, the motility of such dynamic single crystals is triggered by a phase transition or chemical reaction without gaseous products, and macroscopically manifests as either slow (reversible or irreversible) deformation, or as rapid, almost instantaneous propulsion of the crystals that is oftentimes accompanied by disintegration. While the elastic energy of the slow reconfiguration processes such as bending, twisting and coiling can be utilized for actuation of other objects, the fast disintegrative processes could be exploited to initiate pressure-sensitive applications...
September 29, 2016: Chemical Communications: Chem Comm
Yuki Nakano, Masaaki Nasu, Mana Kano, Hiroshi Kameoka, Tetsuya Okuyama, Mikio Nishizawa, Yukinobu Ikeya
Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i...
October 5, 2016: Journal of Natural Medicines
Chandan Kumar Shahi, Aditya Bhattacharyya, Yerramsetti Nanaji, Manas K Ghorai
A simple and efficient synthetic route to 2,3,4,5-tetrahydrobenzoxazepines and -diazepines bearing easily functionalizable appendages has been developed by ring opening of activated aziridines with 2-hydroxyphenylacrylates and 2-aminophenylacrylate, respectively, and subsequent intramolecular C-N bond formation through palladium-catalyzed aza-Michael reaction. The straightforward synthetic approach delivers the desired molecular scaffolds in high yields (up to 82%) with excellent stereoselectivity (ee up to 94%)...
October 5, 2016: Journal of Organic Chemistry
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