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https://www.readbyqxmd.com/read/28527066/community-pharmacies-as-epidemiological-sentinels-of-headache-first-experience-in-italy
#1
Paola Brusa, Marco Parente, Gianni Allais, Sara Rolando, Giuseppe Costa, Roberto Gnavi, Teresa Spadea, Mario Giaccone, Andrea Mandelli, Massimo Mana, Francesca Baratta, Chiara Benedetto, Gennaro Bussone
Migraine is a disabling neurovascular syndrome which affects 12-15% of the global population and it represents the third cause in years lived with disability in both males and females aged 15-49 years. Among migraineurs, the symptomatic drug abuse may be a risk factor in the development of medication overuse headache (MOH). Detecting cases of MOH is not straightforward; community pharmacists may, therefore, be in a strategic position to identify individuals who self-medicate, particularly with respect to prevent the development of MOH...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28514844/measurement-of-the-30-si-mole-fraction-in-the-new-avogadro-silicon-material-by-neutron-activation-and-high-resolution-gamma-spectrometry
#2
Marco Di Luzio, Attila Stopic, Giancarlo D'Agostino, John W Bennett, Giovanni Mana, Massimo Oddone, Axel Pramann
The use of new silicon single crystals highly enriched in (28)Si recently produced for the upcoming redetermination of the Avogadro constant requires knowledge of their molar masses. The isotopic composition data are collected independently in different laboratories but all using the virtual element technique with multi-collector inductively coupled plasma mass spectrometers. In this framework, the comparison of the results with an independent measurement of the amount of at least one of the depleted isotopes is useful to limit hidden systematic errors...
May 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28511481/relationship-of-on-admission-hypocalcaemia-and-illness-severity-as-measured-by-apache-ii-and-sofa-score-in-intensive-care-patients
#3
Samarjit Dey, Habib Md Reazaul Karim, Mohd Yunus, Angkita Barman, Prithwis Bhattacharyya, Manas Pratim Borthakur
INTRODUCTION: Hypocalcaemia is very much prevalent in critically ill patients yet very less is known about its association with severity of illness. Acute Physiology and Chronic Health Evaluation (APACHE) and Sequential Organ Failure Assessment (SOFA) are two commonly used and validated scoring tool used to assess the severity of illness in critically ill patients. AIM: To analyze the relation of on admission hypocalcaemia with severity of illness as measured by APACHE-II and SOFA scores...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28507850/distally-based-sural-artery-peroneus-flap-dbspf-for-foot-and-ankle-reconstruction
#4
Ahmed Ali Ebrahiem, Raj Kumar Manas, Gustavo Vinagre
BACKGROUND: Reconstruction of soft-tissue defects in lower third of leg, ankle, and foot has been a challenge and reconstructive surgeons have been trying to innovate different flaps. To solve this issue, we propose a distally based sural artery peroneus flap (DBSPF) in which we include superficial portion of the peroneus brevis muscle and its blood supply with the peroneal artery distally. The aim of this study was to evaluate the functional outcome and its usefulness over conventional distal sural artery flap or other local options available...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28506887/molecular-investigation-of-virulence-factors-of-brucella-melitensis-and-brucella-abortus-strains-isolated-from-clinical-and-non-clinical-samples
#5
Reza Mirnejad, Faramarz Masjedian Jazi, Shayan Mostafaei, Mansour Sedighi
Brucella is zoonotic pathogen that induces abortion and sterility in domestic mammals and chronic infections in humans called Malta fever. It is a facultative intracellular potential pathogen with high infectivity. The virulence of Brucella is dependent upon its potential virulence factors such as enzymes and cell envelope associated virulence genes. The aim of this study was to investigate the Brucella virulence factors among strains isolated from humans and animals in different parts of Iran. Seventy eight strains of Brucella species isolated from suspected human and animal cases from several provinces of Iran during 2015-2016 and identified by phenotypic and molecular methods...
May 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28506550/cardioprotective-efficacy-of-sevoflurane-vs-propofol-during-induction-and-or-maintenance-in-patients-undergoing-coronary-artery-revascularization-surgery-without-pump-a-randomized-trial
#6
J L Guerrero Orriach, M Galán Ortega, A Ramirez Fernandez, M Ramirez Aliaga, M I Moreno Cortes, D Ariza Villanueva, A Florez Vela, J Alcaide Torres, C Santiago Fernandez, E Matute Gonzalez, E Alsina Marcos, J J Escalona Belmonte, M Rubio Navarro, L Garrido Sanchez, J Cruz Mañas
PURPOSE: Pre and post-operative administration of sevoflurane in myocardial revascularization surgery provides enhanced cardioprotective effects exerted by pharmacologic pre- and post-conditioning, as compared to propofol. The identification of the enzymes involved in conditioning mechanisms is crucial to the understanding of the effects of sevoflurane in cardiac surgery patients. The impact of sevoflurane on another crucial target organ-the kidney-was also assessed. METHODS: Ninety patients undergoing off-pump myocardial revascularization surgery were allocated to receive either intra- and postoperative sevoflurane (SS), intraoperative sevoflurane and postoperative propofol (SP), or intra- and postoperative propofol (PP))...
May 3, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28505448/spectroscopic-and-calorimetric-studies-of-molecular-recognitions-in-a-dendrimer-surfactant-complex
#7
Somnath Koley, Manas Ranjan Panda, Kiran Bharadwaj, Subhadip Ghosh
Molecular recognitions, causing supramolecular complex formation between a hyperbranched polymer molecule (PAMAM dendrimer generation 3) with oppositely charged surfactant sodium dodecyl sulfate (SDS) in aqueous solution, were studied by using various spectroscopic techniques and calorimetric titration of heat change measurements. Spectroscopic measurements were performed using dynamic Stokes shift (DSS), rotational anisotropy decay and translational diffusion of a fluorescent probe molecule coumarin 153 (C153) non-covalently attached to the dendrimer-surfactant complex...
May 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28500896/a-microrna-ubiquitin-ligase-feedback-loop-regulates-slug-mediated-invasion-in-breast-cancer
#8
Rajesh Kumar Manne, Yashika Agrawal, Anil Bargale, Asha Patel, Debasish Paul, Neha Anilkumar Gupta, Srikanth Rapole, Vasudevan Seshadri, Deepa Subramanyam, Praveenkumar Shetty, Manas Kumar Santra
The transformation of a normal cell to cancer requires the derail of multiple pathways. Normal signaling in a cell is regulated at multiple stages by the presence of feedback loops, calibration of levels of proteins by their regulated turnover, and posttranscriptional regulation, to name a few. The tumor suppressor protein FBXO31 is a component of the SCF E3 ubiquitin ligase and is required to arrest cells at G1 following genotoxic stresses. Due to its growth-suppression activity, it is underexpressed in many cancers...
May 9, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28500287/determination-of-nasal-and-oropharyngeal-microbiomes-in-a-multicenter-population-based-study-findings-from-pretest-1-of-the-german-national-cohort
#9
Manas K Akmatov, Nadine Koch, Marius Vital, Wolfgang Ahrens, Dieter Flesch-Janys, Julia Fricke, Anja Gatzemeier, Halina Greiser, Kathrin Günther, Thomas Illig, Rudolf Kaaks, Bastian Krone, Andrea Kühn, Jakob Linseisen, Christine Meisinger, Karin Michels, Susanne Moebus, Alexandra Nieters, Nadia Obi, Anja Schultze, Julia Six-Merker, Dietmar H Pieper, Frank Pessler
We examined acceptability, preference and feasibility of collecting nasal and oropharyngeal swabs, followed by microbiome analysis, in a population-based study with 524 participants. Anterior nasal and oropharyngeal swabs were collected by certified personnel. In addition, participants self-collected nasal swabs at home four weeks later. Four swab types were compared regarding (1) participants' satisfaction and acceptance and (2) detection of microbial community structures based on deep sequencing of the 16 S rRNA gene V1-V2 variable regions...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495502/multipronged-quantitative-proteomics-reveals-serum-proteome-alterations-in-breast-cancer-intrinsic-subtypes
#10
Akshada Gajbhiye, Raju Dabhi, Khushman Taunk, Mashanipalya G Jagadeeshaprasad, Sourav RoyChoudhury, Anupama Mane, Santhakumari Bayatigeri, Koel Chaudhury, Manas K Santra, Srikanth Rapole
Being molecularly heterogeneous, breast cancer tends to be a complicated oncological disease with high incidence rates throughout the world. The primary aim of this study was to identify the set of serum proteins with discriminatory capabilities towards the four major subtypes of breast cancer. We employed multipronged quantitative proteomic approaches like 2D-DIGE, iTRAQ and SWATH-MS and identified 307 differentially regulated proteins. Luminal A subtype consisted of 24, Luminal B subtype 38, HER2 Enriched subtype 17 and Triple negative breast cancer subtype 10 differentially regulated subtype specific proteins...
May 8, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28494936/functional-analysis-of-dendritic-cells-generated-from-t-ipscs-from-cd4-t-cell-clones-of-sj%C3%A3-gren-s-syndrome
#11
Mana Iizuka-Koga, Hiromitsu Asashima, Miki Ando, Chen-Yi Lai, Shinji Mochizuki, Mahito Nakanishi, Toshinobu Nishimura, Hiroto Tsuboi, Tomoya Hirota, Hiroyuki Takahashi, Isao Matsumoto, Makoto Otsu, Takayuki Sumida
Although it is important to clarify the pathogenic functions of T cells in human samples, their examination is often limited due to difficulty in obtaining sufficient numbers of dendritic cells (DCs), used as antigen-presenting cells, especially in autoimmune diseases. We describe the generation of DCs from induced pluripotent stem cells derived from T cells (T-iPSCs). We reprogrammed CD4+ T cell clones from a patient with Sjögren's syndrome (SS) into iPSCs, which were differentiated into DCs (T-iPS-DCs)...
May 9, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28493710/nuclear-localizing-peptide-conjugated-redox-sensitive-polymersomes-for-delivering-curcumin-and-doxorubicin-to-pancreatic-cancer-micro-tumors
#12
Tayebeh Anajafi, Junru Yu, Abbas Sedigh, Manas K Haldar, Wallace W Muhonen, Seth Oberlander, Heather Wasness, Jamie Froberg, Md Shahjahan Molla, Kalpana S Katti, Yongki Choi, John B Shabb, D K Srivastava, Sanku Mallik
Improving the therapeutic index of anticancer agents is an enormous challenge. Targeting decreases the side effects of the therapeutic agents by delivering the drugs to the intended destination. Nanocarriers containing the nuclear localizing peptide sequences (NLS) translocate to the cell nuclei. However, the nuclear localization peptides are non-selective and cannot distinguish the malignant cells from the healthy counterparts. In this study, we designed a "masked" NLS peptide which is activated only in the presence of overexpressed matrix metalloproteinase-7 (MMP-7) enzyme in the pancreatic cancer microenvironment...
May 11, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28492584/-community-pharmacy-towards-a-new-model
#13
Teresa Spadea, Paola Brusa, Roberto Gnavi, Massimo Mana, Mario Giaccone, Giuseppe Costa
In recent years, even in Italy, a new model of "Community pharmacy" is being developed, which identifies the pharmacist as the most accessible health care professional for citizens, and recognizes his role in preventing chronic diseases. A project started in Piedmont (Italy) in 2012 has aimed at applying and evaluating this model of pharmacy in the prevention of diabetes, through the early detection of individuals with undiagnosed diabetes or at high risk of developing the disease, or with counselling to diabetic patients not adhering to the optimal therapeutic pathway...
April 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28492157/angiomyxolipoma-of-tongue
#14
Manas Bajpai, Betina Chandolia, Manika Arora
Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipose tissue associated with a variable amount of myxoid stroma with numerous thick- and thin-walled blood vessels. An exhaustive literature review could reveal only 12 cases of angiomyxolipoma affecting subcutaneous tissue, subungual area and spermatic cord. In oral cavity, only 2 cases of angiomyxolipoma have been reported to date, one case in the buccal mucosa and one case in the floor of the mouth. Hence, this is only the third case of angiomyxolipoma affecting oral cavity and the first case of angiomyxolipoma of the tongue...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28489404/synthetic-routes-toward-acidic-pentasaccharide-related-to-the-o-antigen-of-e-coli-120-using-one-pot-sequential-glycosylation-reactions
#15
Mana Mohan Mukherjee, Rina Ghosh
Concise syntheses of the acidic pentasaccharide, related to the O-antigenic polysaccharide of Escherichia coli 120, as its p-methoxyphenyl glycoside, have been achieved using a one-pot sequential glycosylation technique. The glycosylations have been accomplished either by the activation of the thioglycosides using NIS in the presence of FeCl3 or by a preactivation by Ph2SO, TTBP, Tf2O, and the activation of the trichloroacetimidates using FeCl3 alone or TMSOTf. Most of the intermediate steps are high yielding, and the stereo outcomes of the glycosylation steps were excellent...
May 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28488608/epilepsy-surgery-in-children
#16
REVIEW
Sita Jayalakshmi, Sudhindra Vooturi, Swapan Gupta, Manas Panigrahi
Approximately 60% of all patients with epilepsy suffer from focal epilepsy syndromes. In approximately 15% of these patients, the seizures are not adequately controlled with anticonvulsive drugs, and such patients are potential candidates for surgical treatment and majority are children. Epilepsy surgery in children, who have been carefully chosen, can result in either seizure freedom or a marked (>90%) reduction in seizures in approximately two-third of children with intractable seizures. In the multimodality presurgical evaluation approach, sufficient concordance should be established among various independent investigations, thus identifying the location and extent of the epileptogenic zone with a high degree of confidence...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28482880/changes-in-physical-activity-and-risk-of-all-cause-mortality-in-patients-on-maintence-hemodialysis-a-retrospective-cohort-study
#17
Takahiro Shimoda, Ryota Matsuzawa, Kei Yoneki, Manae Harada, Takaaki Watanabe, Mika Matsumoto, Atsushi Yoshida, Yasuo Takeuchi, Atsuhiko Matsunaga
BACKGROUND: A previous cohort study indicated a significant association of lower baseline level of physical activity in hemodialysis patients with elevated risks of mortality. However, there have been no reports regarding the association between changes in physical activity over time and mortality in hemodialysis patients. This study was performed to examine the prognostic significance of physical activity changes in hemodialysis patients. METHODS: This retrospective cohort study was performed in 192 hemodialysis patients with a 7-year follow-up...
May 8, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28480382/the-effect-of-caffeine-supplementation-on-trained-individuals-subjected-to-maximal-treadmill-test
#18
Viviane Martins Mana Salicio, Carlos Alexandre Fett, Marcos Adriano Salicio, Camila Fernanda Costa Cunha Moraes Brandäo, Luiz Fabrizio Stoppiglia, Waléria Christiane Rezende Fett, And Clovis Botelho
BACKGROUND: Intense physical training increases oxidative stress and inflammation, resulting into muscle and cellular damage. The aim of this study was to analyze the effect of caffeine supplementation on trained young individuals subjected to two treadmill maximal tests. MATERIALS AND METHODS: It was a double-blind and crossover study comprising 24 active individuals within the age group 18-30 years. The comparisons were conducted: the effect of exercise (week 1 x 2) and caffeine intake (GC x GP) on thiobarbituric acid (TBARS), interleukin 6 (IL-6), interleukin 10 (IL-10) and superoxide dismutase (SOD) variables during pre-exercise time (30 min...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28475079/treatment-of-opioid-overdose-a-brief-review-of-naloxone-pharmacology-and-delivery
#19
Thomas M Hendley, Elliot V Hersh, Paul A Moore, Berry Stahl, Mana Saraghi
No abstract text is available yet for this article.
May 2017: General Dentistry
https://www.readbyqxmd.com/read/28468434/enhanced-fluorescence-microscopy-with-the-bull-s-eye-plasmonic-chip
#20
Keiko Tawa, Shota Izumi, Chisato Sasakawa, Chie Hosokawa, Mana Toma
A Bull's eye-plasmonic chip composed of concentric circles was applied to enhanced fluorescence microscopy. Among one dimensional (1-D), 2-D, and Bull's eye periodic structures, the Bull's eye-plasmonic chip provided the most enhanced fluorescence intensity under the epi-fluorescence microscope, because incident light through the objective lens with all azimuthal angles can be effectively applied to the surface plasmon resonance- field (excitation field) and the plasmon-enhanced emission was also effectively collected...
May 1, 2017: Optics Express
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