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https://www.readbyqxmd.com/read/28431948/serum-peptides-as-putative-modulators-of-inflammation-in-psoriasis
#1
Tetsuhiko Matsuura, Masaaki Sato, Kouhei Nagai, Toshiyuki Sato, Mitsumi Arito, Kazuki Omoteyama, Naoya Suematsu, Kazuki Okamoto, Tomohiro Kato, Yoshinao Soma, Manae S Kurokawa
BACKGROUND: Psoriasis is a refractory inflammatory disease, however, its pathophysiology is still not fully understood. OBJECTIVE: We tried to identify novel serum peptides associated with the pathophysiology of psoriasis. METHODS: Serum peptides from 24 patients with psoriasis vulgaris (PV), 10 patients with psoriatic arthritis (PsA), 14 patients with atopic dermatitis (AD), and 23 healthy control (HC) subjects were analyzed by mass spectrometry...
March 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28431852/how-well-does-transfer-of-bacterial-pathogens-by-culture-swabs-correlate-with-transfer-by-hands
#2
Anubhav Kanwar, Thriveen S C Mana, Jennifer L Cadnum, Heba Alhmidi, Sreelatha Koganti, Curtis J Donskey
In laboratory testing and in isolation rooms, pickup and transfer of health care-associated pathogens by premoistened rayon swabs correlated well with pickup and transfer by bare hands or moistened gloves. These results suggest that swab cultures provide a useful surrogate indicator of the risk for pathogen pickup and transfer by hands.
April 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28431298/bioluminescence-emissions-of-female-fireflies-of-the-species-luciola-praeusta
#3
Mana Mohan Rabha, Upamanyu Sharma, Angana Goswami, Anurup Gohain Barua
Numerous investigations have been carried out on bioluminescence emissions from male fireflies. However, very few observations have been made on the emitted light from female specimens. Even in those, apart from observing responses from females to courtship flashes from conspecific males, detailed studies have not been performed. Here we present a first report on the light of female fireflies of the Indian species Luciola praeusta Kiesenwetter 1874 (Coleoptera:Lampyridae:Luciolinae). In the steady-state emission spectrum over the temperature range of 20-40°C, the peak wavelength is the same as, while the full width at half maximum is larger than, that of a male specimen of this species...
April 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28426782/peste-des-petits-ruminants-ppr-a-neglected-tropical-disease-in-maghreb-region-of-north-africa-and-its-threat-to-europe
#4
Ratiba Baazizi, Mana Mahapatra, Brian Donald Clarke, Khatima Ait-Oudhia, Djamel Khelef, Satya Parida
BACKGROUND: Peste des petits ruminants (PPR) is a contagious disease listed by the World Organisation for Animal health (OIE) as being a specific hazard. It affects sheep, goats, and wild ungulates, and is prevalent throughout the developing world particularly Asia, the Middle East, and Africa. PPR has been targeted for eradication by 2030 by the Food and Agriculture Organization of the United Nations (FAO) and the OIE, after the successful eradication of the related disease, rinderpest in cattle...
2017: PloS One
https://www.readbyqxmd.com/read/28424476/neurons-export-extracellular-vesicles-enriched-in-cysteine-string-protein-and-misfolded-protein-cargo
#5
Jingti Deng, Carolina Koutras, Julien Donnelier, Mana Alshehri, Maryam Fotouhi, Martine Girard, Steve Casha, Peter S McPherson, Stephen M Robbins, Janice E A Braun
The fidelity of synaptic transmission depends on the integrity of the protein machinery at the synapse. Unfolded synaptic proteins undergo refolding or degradation in order to maintain synaptic proteostasis and preserve synaptic function, and buildup of unfolded/toxic proteins leads to neuronal dysfunction. Many molecular chaperones contribute to proteostasis, but one in particular, cysteine string protein (CSPα), is critical for proteostasis at the synapse. In this study we report that exported vesicles from neurons contain CSPα...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416399/fabrication-of-semisynthetic-collagenic-materials-for-mere-synergistic-adsorption-a-model-approach-of-determining-dye-allocation-by-systematic-characterization-and-optimization
#6
Mrinmoy Karmakar, Manas Mahapatra, Arnab Dutta, Pijush Kanti Chattopadhyay, Nayan Ranjan Singha
Bovine collagen was functionalized by extensive process modifications for fabricating tanned bovine collagen fibers (TBCFs), as a new semisynthetic macro-, meso- and micro- porous adsorbent, of unprecedented physicochemical properties and excellent industrial waste removal efficiency. Mere or interactive effects were rationally understood, via analyzing monomer-dimer equilibrium, H-/J-aggregate formation, H-bonding, metachromasia, dye-dye complex formation etc., through extensive UV-vis analyses, during removal of acidic, like Acid Brown 369 (AB369), Acid Red 131 (AR131) and Acid Blue 113 (AB113) and basic, like Methylene Blue (MB) dyes...
April 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28413541/clival-giant-cell-tumor-a-rare-case-report-and-review-of-literature-with-respect-to-current-line-of-management
#7
Mohana Rao Patibandla, Amit Kumar Thotakura, Marabathina Nageswara Rao, Gokul Chowdary Addagada, Manisha Chowdary Nukavarapu, Manas Kumar Panigrahi, Shantiveer Uppin, Sundaram Challa, Srinivas Dandamudi
Giant-cell tumor (GCT) involving the skull base is rare. Sphenoid bone is the most commonly involved bone followed by petrous temporal bone. Histopathology and radiological features of these lesions are similar to GCT involving bone elsewhere. Unlike other sites, skull base is not an ideal site for the radical surgery. Hence adjuvant treatment has pivotal role. Radiation therapy with intensity-modulated radiation therapy, stereotactic radiosurgery or chemotherapy with adriamycin are promising as described in some case reports...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413526/neuroendoscopy-is-it-safe
#8
Manas Panigrahi, Bharat Gupta, Rajesh Reddy
BACKGROUND: The effect of heat in endoscopic instruments used for laparoscopy and hysteroscopy has been well-studied. Reports of thermal injury from nasal endoscopes have also been reported. However, there are no experimental studies, which have objectively documented and provided recommendations for safe use of endoscopes in neurosurgery. OBJECTIVES: To study the heat generated at the tip of the endoscope and the subsequent thermal damage caused to a cotton drape placed in proximity, by varying the intensity of light delivered through different optical cables, ambient (operating room) temperatures and working distances...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413523/predictors-of-visual-outcome-with-transsphenoidal-excision-of-pituitary-adenomas-having-suprasellar-extension-a-prospective-series-of-100-cases-and-brief-review-of-the-literature
#9
Amit Kumar Thotakura, Mohana Rao Patibandla, Manas K Panigrahi, Gokul Chowdary Addagada
OBJECTIVE: The aim was to assess the factors influencing the visual outcome following trans-sphenoidal excision of pituitary adenomas. MATERIALS AND METHODS: One hundred consecutive patients of pituitary adenomas with suprasellar extension (SSE) were operated by trans-sphenoidal approach from July 2003 to December 2006. There were 52 male and 48 female patients with a mean age of 42.47 years. The visual impairment score, which was used to evaluate the visual outcome was produced by adding the scores for visual acuity and visual field defects of each patient (from the tables of the German Ophthalmological Society)...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28412074/reversible-synthesis-of-colanic-acid-and-o-antigen-polysaccharides-in-salmonella-typhimurium-enhances-induction-of-cross-immune-responses-and-provides-protection-against-heterologous-salmonella-challenge
#10
Pei Li, Qing Liu, Chun Huang, Xinxin Zhao, Kenneth L Roland, Qingke Kong
Colanic Acid (CA) and lipopolysaccharide (LPS) are two major mannose-containing extracellular polysaccharides of Salmonella. Their presence on the bacterial surface can mask conserved protective outer membrane proteins (OMPs) from the host immune system. The mannose moiety in these molecules is derived from GDP-mannose, which is synthesized in several steps. The first two steps require the action of phosphomannose isomerase, encoded by pmi (manA), followed by phosphomannomutase, encoded by manB. There are two copies of manB present in the Salmonella chromosome, one located in the cps gene cluster (cpsG) responsible for CA synthesis, and the other in the rfb gene cluster (rfbK) involved in LPS O-antigen synthesis...
April 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28411327/racial-differences-in-mental-health-recovery-among-veterans-with-serious-mental-illness
#11
Mana K Ali, Samantha M Hack, Clayton H Brown, Deborah Medoff, Lijuan Fang, Elizabeth A Klingaman, Stephanie G Park, Lisa B Dixon, Julie A Kreyenbuhl
Black consumers with serious mental illness (SMI) face significant challenges in obtaining quality mental health care and are at risk for experiencing significant disparities in mental health care outcomes, including recovery from mental illness. Patient-provider interactions may partly contribute to this disparity. The purpose of the current study was to understand the effects of race, psychosis, and therapeutic alliance on mental health recovery orientation among Veterans with SMI. Participants were Veterans who had an SMI being treated at two Veteran Affairs outpatient mental health clinics by a psychiatrist or nurse practitioner...
April 14, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28405555/linear-and-whorled-nevoid-hypermelanosis-with-depigmentation
#12
Preema Sinha, Manas Chatterjee, Kamlesh K Singh, Aradhana Sood
Linear and whorled nevoid hypermelanosis (LWNH) is a rare disorder of pigmentation characterized by hyperpigmented macules in a linear or whorled streaky configuration. Lesions are distributed mainly on the trunk and extremities, sparing the palms, soles, and mucosae. Depigmentation occurring in the pre-existing whorls has not been reported till date. Herein, we report one such rare case of familial LWNH with depigmentation.
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28405243/transcriptomic-responses-of-the-liver-and-adipose-tissues-to-altered-carbohydrate-fat-ratio-in-diet-an-isoenergetic-study-in-young-rats
#13
Mitsuru Tanaka, Akihito Yasuoka, Manae Shimizu, Yoshikazu Saito, Kei Kumakura, Tomiko Asakura, Toshitada Nagai
BACKGROUND: To elucidate the effects of altered dietary carbohydrate and fat balance on liver and adipose tissue transcriptomes, 3-week-old rats were fed three kinds of diets: low-, moderate-, and high-fat diets (L, M, and H) containing a different ratio of carbohydrate-fat (C-F) (65:15, 60:20, and 35:45 in energy percent, respectively). METHODS: The rats consumed the diets for 9 weeks and were subjected to biochemical and DNA microarray analyses. RESULTS: The rats in the H-group exhibited lower serum triacylglycerol (TG) levels but higher liver TG and cholesterol content than rats in the L-group...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28403945/xanthine-oxidoreductase-activity-is-correlated-with-insulin-resistance-and-subclinical-inflammation-in-young-humans
#14
Kahori Watanabe Washio, Yoshiki Kusunoki, Takayo Murase, Takashi Nakamura, Keiko Osugi, Mana Ohigashi, Tadahiko Sukenaga, Fumihiro Ochi, Toshihiro Matsuo, Tomoyuki Katsuno, Yuji Moriwaki, Tetsuya Yamamoto, Mitsuyoshi Namba, Hidenori Koyama
BACKGROUND AND AIMS: The enzyme xanthine oxidoreductase (XOR) catalyzes the formation of uric acid (UA) from hypoxanthine and xanthine, which in turn are products of purine metabolism starting from ribose-5-phosphate. Besides the synthesis of UA, basic research has suggested that XOR is involved in the regulation of reactive oxygen species, adipogenesis, and peroxisome proliferator-activated receptor-γ (PPAR-γ). XOR activity has shown to be much lower in humans than in rodents, which makes its accurate measurement difficult...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28394705/establishment-of-a-cohort-for-deep-phenotyping-of-the-immune-response-to-influenza-vaccination-among-elderly-individuals-recruited-from-the-general-population
#15
Manas K Akmatov, Peggy Riese, Marcus May, Leonhard Jentsch, Malik W Ahmed, Damaris Werner, Anja Rösel, Megan Tyler, Kevin Pessler, Jana Prokein, Inga Bernemann, Norman Klopp, Blair Prochnow, Stephanie Trittel, Aravind Tallam, Thomas Illig, Christoph Schindler, Carlos A Guzmán, Frank Pessler
Elderly individuals have the highest burden of disease from influenza infection but also the lowest immune response to influenza vaccination. A better understanding of the host response to influenza vaccination in the elderly is therefore urgently needed. We conducted a biphasic prospective, population-based study from Dec. 2014 to May 2015 (pilot study) and Sept. 2015 to May 2016 (main study). Individuals 65-80 y of age were randomly selected from the residents' registration office in Hannover, Germany, for the pilot (n = 34) and main study (n = 200)...
April 10, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28390828/effect-of-gellan-gum-on-the-thermogelation-property-and-drug-release-profile-of-poloxamer-407-based-ophthalmic-formulation
#16
Mitali Dewan, Gunjan Sarkar, Manas Bhowmik, Beauty Das, Atis Kumar Chattoapadhyay, Dipak Rana, Dipankar Chattopadhyay
The effect of gellan gum on the gelation behavior and in-vitro release of a specific drug named pilocarpine hydrochloride from different ophthalmic formulations based on poloxamer 407 is examined. The mixture of 0.3wt% gellan gum and 18wt% poloxamer (PM) solutions show a considerable increase in gel strength in physiological condition. Gel dissolution rate from PM based formulation is significantly decreased due to the addition of gellan gum. FTIR spectra analysis witnesses an interaction in between OH groups of two polymers which accounts for lowering in gelation temperature of PM-gellan gum based formulations...
April 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28384321/correction-evaluation-of-19-460-wheat-accessions-conserved-in-the-indian-national-genebank-to-identify-new-sources-of-resistance-to-rust-and-spot-blotch-diseases
#17
Sundeep Kumar, Sunil Archak, R K Tyagi, Jagdish Kumar, Vikas Vk, Sherry R Jacob, Kalyani Srinivasan, J Radhamani, R Parimalan, M Sivaswamy, P Jayaprakash, Sandhya Tyagi, Mamata Yadav, Jyotisna Rani, Deepali, Sandeep Sharma, Indoo Bhagat, Madhu Meeta, N S Bains, A K Chowdhury, B C Saha, P M Bhattacharya, Jyoti Kumari, M C Singh, O P Gangwar, P Prasad, S C Bharadwaj, Robin Gogoi, J B Sharma, Sandeep Kumar Gm, M S Saharan, Amit Kumar Singh, Z Khan, Manas Bag, Anirban Roy, T V Prasad, R K Sharma, M Dutta, Indu Sharma, K C Bansal
[This corrects the article DOI: 10.1371/journal.pone.0167702.].
2017: PloS One
https://www.readbyqxmd.com/read/28383464/intra-and-interobserver-variability-of-cochlear-length-measurements-in-clinical-ct
#18
John E Iyaniwura, Mai Elfarnawany, Sadegh Riyahi-Alam, Manas Sharma, Zahra Kassam, Yves Bureau, Lorne S Parnes, Hanif M Ladak, Sumit K Agrawal
HYPOTHESIS: The cochlear A-value measurement exhibits significant inter- and intraobserver variability, and its accuracy is dependent on the visualization method in clinical computed tomography (CT) images of the cochlea. BACKGROUND: An accurate estimate of the cochlear duct length (CDL) can be used to determine electrode choice, and frequency map the cochlea based on the Greenwood equation. Studies have described estimating the CDL using a single A-value measurement, however the observer variability has not been assessed...
April 5, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28379236/domino-ring-opening-cyclization-droc-of-activated-aziridines-and-epoxides-with-nitrones-via-dual-catalysis-on-water
#19
Imtiyaz Ahmad Wani, Masthanvali Sayyad, Manas K Ghorai
An efficient and green "on water" regio- and stereoselective synthetic route to chiral 1,2,4-oxadiazinanes and 1,4,2-dioxazinanes with excellent yields (up to 99%) and de/ee (>99%) has been developed for the first time via the domino ring-opening cyclization (DROC) of N-activated aziridines and epoxides with nitrones using LiClO4/Bu4NBF4 a dual catalyst system. The developed green strategy features a broader substrate scope and mild reaction conditions, and successfully overcomes the competitive oxidative ring opening of aziridines...
April 5, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28373107/immuno-informatics-based-approaches-to-identify-cd8-t-cell-epitopes-within-the-leishmania-donovani-3-ectonucleotidase-in-cured-visceral-leishmaniasis-subjects
#20
Vijaya Mahantesh, Ajay Amit, Manas R Dikhit, Ashish K Singh, T Venkateshwaran, V N R Das, Pradeep Das, Sanjiva Bimal
Leishmaniases are vector-borne diseases for which no vaccine exists. These diseases are caused by the Leishmania species complex. Activation of the CD8(+) T cell is crucial for protection against intracellular pathogens, and peptide antigens are attractive strategies for the precise activation of CD8(+) T in vaccine development against intracellular infections. The traditional approach to mine the epitopes is an arduous task. However, with the advent of immunoinformatics, in silico epitope prediction tools are available to expedite epitope identification...
April 1, 2017: Microbes and Infection
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