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https://www.readbyqxmd.com/read/29777467/methemoglobinemia-a-girl-with-chocolate-brown-colored-blood
#1
Manas Kumar Mahapatra, Prabhas Prasun Giri
No abstract text is available yet for this article.
May 18, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29775225/cytokines-and-chemokines-differentially-regulate-innate-immune-cell-trafficking-during-post-kala-azar-dermal-leishmaniasis
#2
Ashish K Singh, Vidya N R Das, Ajay Amit, Manas R Dikhit, Vijaya Mahantesh, Shubhankar K Singh, Shyam Naryan, Krishna Pandey, Pradeep Das, Neena Verma, Sanjiva Bimal
Post kala-azar dermal leishmaniasis (PKDL) is often considered to be the anthroponotic reservoir of visceral leishmaniasis (VL) in India. A better understanding of the host immune-response in dermal lesions of PKDL patients is therefore of utmost significance to minimize such patients and to restrict VL transmission. Although the innate immune response is known to play an important role in parasite clearance from dermal lesions, the actual contribution of innate cells to the pathogenicity of PKDL is poorly understood...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29774158/efficacy-of-vedolizumab-for-induction-of-clinical-response-and-remission-in-patients-with-moderate-to-severe-inflammatory-bowel-disease-who-failed-at-least-two-tnf-antagonists
#3
Martine De Vos, Barbara Dhooghe, Severine Vermeire, Edouard Louis, Fazia Mana, Ann Elewaut, Peter Bossuyt, Filip Baert, Catherine Reenaers, Marc Van Gossum, Elisabeth Macken, Marc Ferrante, Pieter Hindryckx, Olivier Dewit, Tom Holvoet, Denis Franchimont
Background: Vedolizumab is a recently available monoclonal antibody targeting α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). Objective: The objective of this article is to evaluate the efficacy of vedolizumab induction therapy in anti-TNF-refractory/intolerant UC and CD patients in real life. Methods: A cohort of 149 moderately to severely active UC and CD patients who failed or showed intolerance to at least two TNF antagonists participated in a medical need program and received vedolizumab in 37 Belgian centers (April-September 2015)...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29765542/smar1-inhibits-wnt-%C3%AE-catenin-signaling-and-prevents-colorectal-cancer-progression
#4
Nandaraj Taye, Aftab Alam, Suvankar Ghorai, Deya Ghosh Chatterji, Apoorva Parulekar, Devraj Mogare, Snahlata Singh, Pallabi Sengupta, Subhrangsu Chatterjee, Manoj Kumar Bhat, Manas Kumar Santra, Prabhakar Budha Salunkhe, Susan Kling Finston, Samit Chattopadhyay
Reduced expression of Scaffold/Matrix Attachment Region Binding Protein 1 (SMAR1) is associated with various cancers resulting in poor prognosis of the diseases. However, the precise underlying mechanism elucidating the loss of SMAR1 requires ongoing study. Here, we show that SMAR1 is highly downregulated during aberrant Wnt3a signaling due to proteasomal degradation and predicted poor prognosis of colorectal cancer. However, substitution mutation (Arginine and Lysine to Alanine) in the D-box elements of SMAR1 viz...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29756922/squeezing-enhances-quantum-synchronization
#5
Sameer Sonar, Michal Hajdušek, Manas Mukherjee, Rosario Fazio, Vlatko Vedral, Sai Vinjanampathy, Leong-Chuan Kwek
It is desirable to observe synchronization of quantum systems in the quantum regime, defined by the low number of excitations and a highly nonclassical steady state of the self-sustained oscillator. Several existing proposals of observing synchronization in the quantum regime suffer from the fact that the noise statistics overwhelm synchronization in this regime. Here, we resolve this issue by driving a self-sustained oscillator with a squeezing Hamiltonian instead of a harmonic drive and analyze this system in the classical and quantum regime...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29754381/non-tuberculous-mycobacterial-infections-in-thoracic-transplant-candidates-and-recipients
#6
REVIEW
Mana Rao, Fernanda P Silveira
PURPOSE OF REVIEW: To review and discuss the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of non-tuberculous mycobacteria (NTM) in thoracic transplantation. RECENT FINDINGS: Non-tuberculous mycobacteria are ubiquitous but are an uncommon cause of disease after solid organ transplantation. The incidence of infection is higher in thoracic transplant recipients than in abdominal transplant recipients, with most cases seen after lung transplantation...
May 12, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29754160/response-to-neoadjuvant-chemotherapy-for-breast-cancer-judged-by-percist-multicenter-study-in-japan
#7
Kazuhiro Kitajima, Koya Nakatani, Kazushige Yamaguchi, Masatoyo Nakajo, Atsushi Tani, Mana Ishibashi, Keiko Hosoya, Takahiro Morita, Takayuki Kinoshita, Hayato Kaida, Yasuo Miyoshi
PURPOSE: The purpose of this study was to evaluate therapeutic response to neoadjuvant chemotherapy (NAC) and predict breast cancer recurrence using Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST). MATERIALS AND METHODS: Fifty-nine breast cancer patients underwent fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) before and after NAC prior to planned surgical resection. Pathological complete response (pCR) of the primary tumor was evaluated using PERCIST, while effects of clinicopathological factors on progression-free survival (PFS) were examined using log-rank and Cox methods...
May 12, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29753087/effects-of-salazosulfapyridine-on-the-profile-of-cell-surface-proteins-revealed-by-biotinylation-of-cell-surface-proteins-and-2-dimentional-electrophoresis
#8
Kazuki Omoteyama, Toshiyuki Sato, Mitsumi Arito, Masaaki Sato, Naoya Suematsu, Manae S Kurokawa, Tomohiro Kato
OBJECTIVE: We investigated effects of salazosulfapyridine (SASP) on the protein profile of cell surface (CS)-proteins of SW982, a human synovial sarcoma cell line, using biotinylation of CS-proteins and 2-dimensional fluorescence difference gel electrophoresis (2D-DIGE). METHODS: SW982 cells were treated with SASP and its metabolites, sulfapyridine (SP) and 5-aminosalicylic acid (5ASA). Then the cells were treated with a membrane-impermeable biotinylating reagent...
May 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29752045/stressors-of-school-age-children-with-allergic-diseases-a-qualitative-study
#9
Misa Iio, Mana Hamaguchi, Mayumi Nagata, Koichi Yoshida
PURPOSE: Most studies of stress in children with chronic diseases have been geared toward parents and caregivers have not considered allergic diseases together. This study aimed to identify the stressors associated with allergic diseases in Japanese school-age children. DESIGN AND METHODS: Stressors associated with allergic diseases of 11 school-age children (seven boys and four girls; age range: 9-12 years) were investigated using semi-structured interviews. RESULTS: In the qualitative thematic analysis of stressors about allergic diseases, two themes: allergic disease-specific stressors and common stressors in chronic diseases, and 12 categories were identified...
May 8, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29751404/can-a-growth-model-be-used-to-describe-forest-carbon-and-water-balance-after-fuel-reduction-burning-in-temperate-forests
#10
Mana Gharun, Malcolm Possell, R Willem Vervoort, Mark A Adams, Tina L Bell
Empirical evidence from Australia shows that fuel reduction burning significantly reduces the incidence and extent of unplanned fires. However, the integration of environmental values into fire management operations is not yet well-defined and requires further research and development. WAVES, a plant growth model that incorporates Soil-Vegetation-Atmosphere Transfer, was used to simulate the hydrological and ecological effects of three fuel management scenarios on a forest ecosystem. WAVES was applied using inputs from a set of forest plots for one year after three potential scenarios: (1) all litter removed, (2) all litter and 50% of the understorey removed, (3) all litter and understorey removed...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29749993/central-acinic-cell-carcinoma-of-the-mandible-simulating-as-benign-odontogenic-lesion-a-case-report
#11
Manas Bajpai, Nilesh Pardhe, Betina Chandolia, Manika Arora
Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approximately 2% of the salivary gland tumors with almost 90% arising in the parotid gland. The rest involve the submandibular and the minor salivary gland. ACC of the jaw is extremely rare and, to our knowledge, only 8 cases have been reported in the English literature...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749663/inter-individual-responses-to-different-exercise-stimuli-among-insulin-resistant-women
#12
C Álvarez, R Ramírez-Vélez, R Ramírez-Campillo, I Shigenori, C Celis-Morales, A García-Hermoso, L Rodriguez-Mañas, A Lucia, M Izquierdo
We aimed to investigate which among 20-cardiometabolic and performance outcomes do and do not respond to high-intensity interval training (HIT), resistance training (RT), or concurrent training (CT) in insulin-resistant adult women. A secondary aim was to report the training-induced changes and the prevalence of non-responders. Forty-five insulin-resistant adult women were randomly assigned to one of the following four groups: HIT (39.2±9.5 years [y]; body mass index [BMI], 29.3±3.3; n=14), RT (33.9±9.3 y; BMI, 29...
May 11, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29749539/somatic-copy-number-alterations-have-prognostic-impact-in-patients-with-ovarian-clear-cell-carcinoma
#13
Asuka Morikawa, Tomoatsu Hayashi, Mana Kobayashi, Yuki Kato, Katsuhiko Shirahige, Takehiko Itoh, Mitsuyoshi Urashima, Aikou Okamoto, Tetsu Akiyama
Ovarian clear cell carcinoma (OCCC) is a chemotherapy‑resistant epithelial ovarian cancer with poor prognosis. To identify genomic alterations involved in the development of OCCC, we analyzed somatic copy number alterations in OCCC using comparative genomic hybridization (CGH). Here we showed that the chromosomal regions 8p11.21, 8p11.22, 12p13.31 and 20q13.2 were amplified in OCCC. We also demonstrated that small segments in the chromosomal regions 3q26.1, 4q13.2 and 22q11.23 were deleted. Kaplan‑Meier survival analyses revealed that patients with amplification within 8p11...
May 8, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29745988/differential-requirements-for-irf4-in-the-clonal-expansion-and-homeostatic-proliferation-of-naive-and-memory-murine-cd8-t-cells
#14
Mana Miyakoda, Kiri Honma, Daisuke Kimura, Masoud Akbari, Kazumi Kimura, Toshifumi Matsuyama, Katsuyuki Yui
Interferon regulatory factor 4 (IRF4) has critical roles in immune cell differentiation and function and is indispensable for clonal expansion and effector function in T cells. Here, we demonstrate that the AKT pathway is impaired in murine CD8+ T cells lacking IRF4. The expression of phosphatase and tensin homolog (PTEN), a negative regulator of the AKT pathway, was elevated in Irf4-/- CD8+ T cells. Inhibition of PTEN partially rescued downstream events, suggesting that PTEN constitutes a checkpoint in the IRF4-mediated regulation of cell signaling...
May 10, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29745149/-effects-of-grazing-and-mowing-on-macrofauna-communities-in-a-typical-steppe-of-inner-mongolia-china
#15
Xia Liu, Dong Zhao, Jian Wei Cheng, Hai Yan Chen, Xin Min Liu, Taogetao Baoyin, Frank Yonghong Li
The dynamic features of the ecosystem components under different human activities are fundamental for understanding the ecosystem change mechanisms and developing sustainable mana-gement system. For the vast temperate steppe ecosystems in northern China, there existed many studies on the effects of animal grazing and mowing on plant and soil microbial communities, but not the soil fauna communities. We investigated the soil macrofauna communities of a typical Inner Mongolia steppe grassland under 6 utilization treatments (1 full season grazing, 3 different seasonal grazing, 1 autumn mowing and 1 control of no grazing or mowing)...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29740456/newly-identified-wild-rice-accessions-conferring-high-salt-tolerance-might-use-a-tissue-tolerance-mechanism-in-leaf
#16
Manas R Prusty, Sung-Ryul Kim, Ricky Vinarao, Frederickson Entila, James Egdane, Maria G Q Diaz, Kshirod K Jena
Cultivated rice ( Oryza sativa L.) is very sensitive to salt stress. So far a few rice landraces have been identified as a source of salt tolerance and utilized in rice improvement. These tolerant lines primarily use Na+ exclusion mechanism in root which removes Na+ from the xylem stream by membrane Na+ and K+ transporters, and resulted in low Na+ accumulation in shoot. Identification of a new donor source conferring high salt tolerance is imperative. Wild relatives of rice having wide genetic diversity are regarded as a potential source for crop improvement...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29739190/charge-transfer-character-drives-m%C3%A3-bius-antiaromaticity-in-the-excited-triplet-state-of-twisted-28-hexaphyrin
#17
Fumitoshi Ema, Mana Tanabe, Shohei Saito, Tomoki Yoneda, Kenji Sugisaki, Takashi Tachikawa, Seiji Akimoto, Seigo Yamauchi, Kazunobu Sato, Atsuhiro Osuka, Takeji Takui, Yasuhiro Kobori
Möbius aromatic molecules have attracted great attention as new functional materials because of their π-orbital cyclic conjugations lying along the twisted Möbius topology. To elucidate the electronic character of the lowest excited triplet (T1 ) state of a Möbius aromatic [28]hexaphyrin, we employed a time-resolved electron paramagnetic resonance (TREPR) method with applied magnetophotoselection measurements at 77 K. Analyses of the EPR parameters have revealed that the T1 state possesses intramolecular charge-transfer (CT) character together with local excitation character residing at one side in the Möbius strip ring...
May 9, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29738899/factors-associated-with-poor-balance-ability-in-older-adults-of-nine-high-altitude-communities
#18
Diego Urrunaga-Pastor, Enrique Moncada-Mapelli, Fernando M Runzer-Colmenares, Zaira Bailon-Valdez, Rafael Samper-Ternent, Leocadio Rodriguez-Mañas, Jose F Parodi
INTRODUCTION: Poor balance ability in older adults result in multiple complications. Poor balance ability has not been studied among older adults living at high altitudes. In this study, we analysed factors associated with poor balance ability by using the Functional Reach (FR) among older adults living in nine high-altitude communities. MATERIAL AND METHODS: Analytical cross-sectional study, carried out in inhabitants aged 60 or over from nine high-altitude Andean communities of Peru during 2013-2016...
May 1, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29738257/stereospecific-synthesis-of-1-4-5-6-tetrahydropyrimidines-via-domino-ring-opening-cyclization-of-activated-aziridines-with-%C3%AE-acidic-isocyanides
#19
Aditya Bhattacharyya, Chandan Kumar Shahi, Sajan Pradhan, Manas K Ghorai
An expeditious synthetic route to access structurally diverse 1,4,5,6-tetrahydropyrimidines via domino ring-opening cyclization of activated aziridines with α-acidic isocyanides has been established. The transformation proceeds via Lewis acid mediated SN 2-type ring opening of activated aziridines with α-carbanion of the isocyanides followed by a concomitant 6- endo- dig cyclization in a domino fashion to furnish the 1,4,5,6-tetrahydropyrimidine derivatives in excellent yields (up to 84%) and also in diastereo- and enantiomerically pure form (dr >99:1, ee >99%)...
May 8, 2018: Organic Letters
https://www.readbyqxmd.com/read/29737046/petaloid-recombinant-peptide-enhances-in-vitro-cartilage-formation-by-synovial-mesenchymal-stem-cells
#20
Mana Naritomi, Mitsuru Mizuno, Hisako Katano, Nobutake Ozeki, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Shizuko Ichinose, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya
In vitro chondrogenesis of mesenchymal stem cells (MSCs) mimics in vivo chondrogenesis of MSCs. However, the size of the cartilage pellets that can be attained in vitro is limited by current methods; therefore, some modifications are required to obtain larger pellets. Petaloid pieces of recombinant peptide (petaloid RCP) have the advantage of creating spaces between cells in culture. The RCP used here is based on the alpha-1 sequence of human collagen type I and contains 12 Arg-Gly-Asp motifs. We examined the effect and mechanisms of adding petaloid RCP on the in vitro chondrogenesis of human synovial MSCs by culturing 125k cells with or without 0...
May 7, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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