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https://www.readbyqxmd.com/read/29150943/muscle-regeneration-potential-and-satellite-cell-activation-profile-during-recovery-following-hindlimb-immobilization-in-mice
#1
Maria Guitart, Josep Lloreta, Laura Mañas-Garcia, Esther Barreiro
Reduced muscle activity leads to muscle atrophy and function loss in patients and animal models. Satellite cells (SCs) are postnatal muscle stem cells that play a pivotal role in skeletal muscle regeneration following injury. The regenerative potential, satellite cell numbers, and markers during recovery following immobilization of the hindlimb for seven days were explored. In mice exposed to seven days of hindlimb immobilization, in those exposed to recovery (seven days, splint removal), and in contralateral control muscles, muscle precursor cells were isolated from all hindlimb muscles (fluorescence-activated cell sorting, FACS), and SCs and muscle regeneration were identified using immunofluorescence (gastrocnemius and soleus) and electron microscopy (EM, gastrocnemius)...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29149820/mechanisms-of-cardioprotection-of-halogenated-agents-during-extracorporeal-circulation-in-cardiac-surgery
#2
M Ramirez Aliaga, J J Escalona Belmonte, Alicia Ramirez-Fernandez, M Rubio Navarro, J Cruz Manas
The implementation of cardioprotective strategies involving pre-, intra-, and postoperative interventions is key during cardiac surgery requiring extracorporeal circulation (ECC). The primary goal of this study was to review the physiopathology of and protection strategies against myocardial damage secondary to ECC during cardiac surgery. The administration of halogenated anesthetics for cardiac anesthesia is commonplace due to their well-known cardioprotective effects and their capacity to ensure hypnosis...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29149814/calcium-channel-sensitizers-in-cardiac-surgery-who-when-how-and-why
#3
Jose Luis Guerrero Orriach, A Ramirez Fernandez, J J Escalona Belmonte, M Rubio Navarro, M Rubio Navarro, J Cruz Manas
we try to answer four questions in this review, what type of patients need this drug; what is the best time to start with it, the best way that we could give it and finally the reasons for use it.
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29145201/dietary-fructo-oligosaccharides-attenuate-early-activation-of-cd4-t-cells-which-produce-both-th1-and-th2-cytokines-in-the-intestinal-lymphoid-tissues-of-a-murine-food-allergy-model
#4
Masato Tsuda, Haruka Arakawa, Narumi Ishii, Chihiro Ubukata, Mana Michimori, Masanari Noda, Kyoko Takahashi, Shuichi Kaminogawa, Akira Hosono
BACKGROUND: Fructo-oligosaccharides (FOS) are prebiotic agents with immunomodulatory effects involving improvement of the intestinal microbiota and metabolome. In this study, we investigated the cellular mechanisms through which FOS modulate intestinal antigen-specific CD4+ T cell responses in food allergy, using OVA23-3 mice. METHODS: OVA23-3 mice were fed an experimental diet containing either ovalbumin (OVA) or OVA and FOS for 1 week. Body weight and mucosal mast cell protease 1 in the serum were measured as the indicator of intestinal inflammation...
November 17, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29140228/co-factor-independent-phosphoglycerate-mutase-of-leishmania-donovani-modulates-macrophage-signalling-and-promotes-t-cell-repertoires-bearing-epitopes-for-both-mhc-i-and-mhc-ii
#5
Manish K Singh, Fauzia Jamal, Amit K Dubey, Pushkar Shivam, Sarita Kumari, Pushpanjali, Ghufran Ahmed, Manas R Dikhit, S Narayan, V N R DAS, Krishna Pandey, K K Sinha, P DAS, Shubhankar K Singh
Immunoactivation depends upon the antigen potential to modulate T-cell repertoires. The present study has enumerated the effect of 61 kDa recombinant Leishmania donovani co-factor-independent phosphoglycerate mutase (rLd-iPGAM) on mononuclear cells of healthy and treated visceral leishmaniasis subjects as well as on THP-1 cell line. rLd-iPGAM stimulation induced higher expression of interleukin-1β (IL-1β) in the phagocytic cell, its receptor and CD69 on T-cell subsets. These cellular activations resulted in upregulation of host-protective cytokines IL-2, IL-12, IL-17, tumour necrosis factor-α and interferon-γ, and downregulation of IL-4, IL-10 and tumour growth factor-β...
November 15, 2017: Parasitology
https://www.readbyqxmd.com/read/29138085/in-silico-design-cloning-expression-and-immunologic-evaluation-of-ed-fusion-protein-of-nt-h-influenzae
#6
Ava Behrouzi, Saeid Bouzari, Mana Oloomi, Abolfaz Fateh, Farzam Vaziri, Parviz Afrough, Amir Amanzadeh, Seyed Davar Siadat
Infections due to nontypeable Haemophilus influenzae (NTHi) are important causes of child mortality throughout the world. Given the lack of effective vaccines for these strains and the spread and prevalence of these infections in the world, it is necessary to design novel vaccine candidates against these strains. D and E proteins are conserved membrane-specific lipoproteins among encapsulated and non-encapsulated H. influenza strains, which, according to the exposure surface and conservation degree between both strains, can be considered as vaccine candidates suitable for studies...
November 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29135268/chemoselective-one-pot-synthesis-of-functionalized-amino-azaheterocycles-enabled-by-coware
#7
Thomas A Clohessy, Alastair Roberts, Eric S Manas, Vipulkumar K Patel, Niall A Anderson, Allan J B Watson
Functionalized bicyclic amino-azaheterocycles are rapidly accessed in a one-pot cross-coupling/reduction sequence enabled by the use of COware. Incompatible reagents are physically separated in a single reaction vessel to effect two chemoselective transformations-Suzuki-Miyaura cross-coupling and heteroarene reduction. The developed method allows access to novel heterocyclic templates, including semisaturated Hedgehog and dual PI3K/mTOR inhibitors, which show enhanced physicochemical properties compared to their unsaturated counterparts...
November 14, 2017: Organic Letters
https://www.readbyqxmd.com/read/29132495/solitary-neurofibroma-of-gingiva-an-immunohistochemical-interpretation-using-s-100
#8
Manas Bajpai, Manika Arora, Betina Chandolia
No abstract text is available yet for this article.
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29131835/no-evidence-of-critical-slowing-down-in-two-endangered-hawaiian-honeycreepers
#9
Jessica C Rozek, Richard J Camp, J Michael Reed
There is debate about the current population trends and predicted short-term fates of the endangered forest birds, Hawai`i Creeper (Loxops mana) and Hawai`i `Ākepa (L. coccineus). Using long-term population size estimates, some studies report forest bird populations as stable or increasing, while other studies report signs of population decline or impending extinction associated with introduced Japanese White-eye (Zosterops japonicus) increase. Reliable predictors of impending population collapse, well before the collapse begins, have been reported in simulations and microcosm experiments...
2017: PloS One
https://www.readbyqxmd.com/read/29126339/the-force-velocity-relationship-in-older-people-reliability-and-validity-of-a-systematic-procedure
#10
Julian Alcazar, Carlos Rodriguez-Lopez, Ignacio Ara, Ana Alfaro-Acha, Asier Mañas-Bote, Amelia Guadalupe-Grau, Francisco Jose García-García, Luis M Alegre
This study compared the reliability and validity of different protocols evaluating the force-velocity (F-V) relationship and muscle power in older adults. Thirty-one older men and women (75.8±4.7 years) underwent two F-V tests by collecting the mean and peak force and velocity data exerted against increasing loads until one repetition maximum (1RM) was achieved in the leg press exercise. Two attempts per load were performed, with a third attempt when F-V points deviated from the linear F-V regression equation...
November 10, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29123264/neutrophils-driving-progression-and-poor-prognosis-in-hepatocellular-carcinoma
#11
Jane Margetts, Laura F Ogle, Stephen L Chan, Anthony W H Chan, K C Allen Chan, David Jamieson, Catherine E Willoughby, Derek A Mann, Caroline L Wilson, Derek M Manas, Winnie Yeo, Helen L Reeves
BACKGROUND: Irrespective of the underlying aetiology, 90% of hepatocellular carcinomas arise and progress on a background of chronic inflammation. We have explored the independent prognostic value of circulating inflammatory cells. METHODS: Peripheral blood count data sets from 583 consecutive patients presenting to a single UK centre (2000-2010) were analysed for associations with tumour stage, liver function, performance status (PST) and survival. Validation was in an independent Hong Kong cohort (585 patients; 2007-2013)...
November 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29114293/solitary-giant-extradural-plasmacytoma
#12
H Raghavendra, M Dilip Kumar, Manas Panigraghi, Shailaja M Reddy
Solitary plasmacytoma of the skull is very rare, and only a few cases have been reported in the literature. It remains controversial whether solitary plasmacytoma of the skull is essentially identical with solitary plasmacytoma of bone or not. Solitary plasmacytoma of bone including solitary plasmacytoma of the skull is characterized by a radiologically solitary bone lesion, neoplastic plasma cells in the biopsy specimen, fewer than 5% plasma cells in bone marrow, <2.0 g/dl monoclonal protein in the serum when present and negative urine test for Bence Jones protein (monoclonal light chain)...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29107648/corrigendum-to-european-contribution-to-the-study-of-ros-a-summary-of-the-findings-and-prospects-for-the-future-from-the-cost-action-bm1203-eu-ros-redox-biol-13-2017-94-162
#13
J Egea, I Fabregat, Y M Frapart, P Ghezzi, A Görlach, T Kietzmann, K Kubaichuk, U G Knaus, M G Lopez, G Olaso-Gonzalez, A Petry, R Schulz, J Vina, P Winyard, K Abbas, O S Ademowo, C B Afonso, I Andreadou, H Antelmann, F Antunes, M Aslan, M M Bachschmid, R M Barbosa, V Belousov, C Berndt, D Bernlohr, E Bertrán, A Bindoli, S P Bottari, P M Brito, G Carrara, A I Casas, A Chatzi, N Chondrogianni, M Conrad, M S Cooke, J G Costa, A Cuadrado, P My-Chan Dang, B De Smet, B Debelec-Butuner, I H K Dias, J D Dunn, A J Edson, M El Assar, J El-Benna, P Ferdinandy, A S Fernandes, K E Fladmark, U Förstermann, R Giniatullin, Z Giricz, A Görbe, H Griffiths, V Hampl, A Hanf, J Herget, P Hernansanz-Agustín, M Hillion, J Huang, S Ilikay, P Jansen-Dürr, V Jaquet, J A Joles, B Kalyanaraman, D Kaminskyy, M Karbaschi, M Kleanthous, L O Klotz, B Korac, K S Korkmaz, R Koziel, D Kračun, K H Krause, V Křen, T Krieg, J Laranjinha, A Lazou, H Li, A Martínez-Ruiz, R Matsui, G J McBean, S P Meredith, J Messens, V Miguel, Y Mikhed, I Milisav, L Milković, A Miranda-Vizuete, M Mojović, M Monsalve, P A Mouthuy, J Mulvey, T Münzel, V Muzykantov, I T N Nguyen, M Oelze, N G Oliveira, C M Palmeira, N Papaevgeniou, A Pavićević, B Pedre, F Peyrot, M Phylactides, G G Pircalabioru, A R Pitt, H E Poulsen, I Prieto, M P Rigobello, N Robledinos-Antón, L Rodríguez-Mañas, A P Rolo, F Rousset, T Ruskovska, N Saraiva, S Sasson, K Schröder, K Semen, T Seredenina, A Shakirzyanova, G L Smith, T Soldati, B C Sousa, C M Spickett, A Stancic, M J Stasia, H Steinbrenner, V Stepanić, S Steven, K Tokatlidis, E Tuncay, B Turan, F Ursini, J Vacek, O Vajnerova, K Valentová, F Van Breusegem, L Varisli, E A Veal, A S Yalçın, O Yelisyeyeva, N Žarković, M Zatloukalová, J Zielonka, R M Touyz, A Papapetropoulos, T Grune, S Lamas, H H H W Schmidt, F Di Lisa, A Daiber
No abstract text is available yet for this article.
October 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/29102329/genetic-and-antigenic-characterization-of-serotype-o-fmd-viruses-from-east-africa-for-the-selection-of-suitable-vaccine-strain
#14
Katie Lloyd-Jones, Mana Mahapatra, Sasmita Upadhyaya, David J Paton, Aravindh Babu, Geoff Hutchings, Satya Parida
Foot-and-mouth disease (FMD) is endemic in Eastern Africa with circulation of multiple serotypes of the virus in the region. Most of the outbreaks are caused by serotype O followed by serotype A. The lack of concerted FMD control programmes in Africa has provided little incentive for vaccine producers to select vaccines that are tailored to circulating regional isolates creating further negative feedback to deter the introduction of vaccine-based control schemes. In this study a total of 80 serotype O FMD viruses (FMDV) isolated from 1993 to 2012 from East and North Africa were characterized by virus neutralisation tests using bovine antisera to three existing (O/KEN/77/78, O/Manisa and O/PanAsia-2) and three putative (O/EA/2002, O/EA/2009 and O/EA/2010) vaccine strains and by capsid sequencing...
November 1, 2017: Vaccine
https://www.readbyqxmd.com/read/29101404/autoreactive-t-cells-in-immunopathogenesis-of-tb-associated-uveitis
#15
Ravichandra Tagirasa, Shaifaly Parmar, Manas R Barik, Satish Devadas, Soumyava Basu
Purpose: Intraocular inflammation in tuberculosis-associated uveitis (TBU) is usually widespread, and responds unpredictably to treatment. Herein, we analyze the intraocular T-cell response in TBU for its surface phenotype, antigenic specificity, and functional characteristics to explain the above observations. Methods: We isolated T cells from vitreous humor samples of patients with TBU and non-TB uveitis (controls). These were directly stained for surface markers CD4, CD8, CD45RO, CD45RA, CCR7, as well as intracellular cytokines IFN-γ, TNF-α, and IL-17 and analyzed on flow cytometry...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29099366/cardiovascular-considerations-for-the-dental-practitioner-1-review-of-cardiac-anatomy-and-preoperative-evaluation
#16
Kenneth Kufta, Mana Saraghi, Helen Giannakopoulos
Cardiovascular disease is the most prevalent chronic medical condition in patients treated in a dental setting. Therefore, dental practitioners must have a sound understanding of cardiovascular anatomy and physiology. Dentists also should be equipped to perform an effective preoperative cardiovascular examination and determine when medical consultation is necessary in higher risk patients. This article provides an overview of cardiovascular anatomy and physiology and discusses evaluation of cardiac risk factors with the aim of enabling dentists to effectively assess patients for potential cardiovascular events, thereby avoiding cardiovascular emergencies in the dental setting...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29093343/alterations-in-cisplatin-pharmacokinetics-and-its-acute-sub-chronic-kidney-injury-over-multiple-cycles-of-cisplatin-treatment-in-rats
#17
Akira Okada, Keizo Fukushima, Mai Fujita, Mana Nakanishi, Mami Hamori, Asako Nishimura, Nobuhito Shibata, Nobuyuki Sugioka
Cisplatin (CDDP)-induced acute kidney injury (AKI) is a major clinical concern. CDDP treatment is generally conducted with multiple cycles; the magnitude of the CDDP-induced AKI may be altered by these cycles. Moreover, sub-chronic kidney injury (sCKI) induced by repeated CDDP treatment is often associated with renal interstitial fibrosis, potentially leading to chronic kidney disease. Therefore, it is suggested that the management of not only AKI but also sCKI induced by CDDP in multiple cycles plays an important role in the outcome of CDDP-based chemotherapy...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29091092/three-dimensional-morphometry-of-collagen-fibrils-in-membranous-bone
#18
Mana Hashimoto, Noriyuki Nagaoka, Kaori Tabata, Tomoyo Tanaka, Ryuta Osumi, Naoya Odagaki, Toru Hara, Hiroshi Kamioka
The collagen network acts as a scaffold for calcification and its three-dimensional structure influences bone strength. It is therefore important to observe the collagen network in detail and three-dimensionally. In this study, we observed the collagen network of chick embryonic calvariae in membranous bone three-dimensionally using orthogonally arranged FIB-SEM. A 25 × 25 μm area of chick embryonic calvaria was observed at a high resolution (25 nm per pixel). The inside of the bone (i.e. the primary calcified tissue), the bone cells (i...
November 13, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29083444/aeroaging-a-new-collaboration-between-life-sciences-experts-and-aerospace-engineers
#19
M Vellas, C Fualdes, J E Morley, C Dray, L Rodriguez-Manas, A Meyer, L Michel, Y Rolland, Y Gourinat
An open discussion between experts from life sciences and aeronautics has been held in order to investigate how both area of research overlap and could be relevant to each other, precisely on the topic of aging. Similarities in aging processes and prediction methodologies have been identified between human aging and aircraft aging. Two axis of collaboration have been raised: 1) The identification of the determinants in Aircraft aging (structural aging). 2) The development of P4 Systems medicine inspired new methodologies in the predictive maintenance...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29083438/global-performance-of-executive-function-is-predictor-of-risk-of-frailty-and-disability-in-older-adults
#20
C Rosado-Artalejo, J A Carnicero, J Losa-Reyna, C Castillo, B Cobos-Antoranz, A Alfaro-Acha, L Rodríguez-Mañas, F J García-García
INTRODUCTION: The executive function is a complex set of skills affected during the aging process and translate into subclinical cerebrovascular disease. Postural instability or motor slowness are some clinical manifestations, being consubstantial with the frailty phenotype, genuine expression of aging. Executive dysfunction is also considered a predictor of adverse health events in the elderly. AIM: To study whether the executive dysfunction can be used as an early marker for frailty and the viability of use as a predictor of mortality, hospitalization and/or disability in a Mediterranean population...
2017: Journal of Nutrition, Health & Aging
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