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https://www.readbyqxmd.com/read/29224318/-distribution-and-drug-resistance-of-pathogens-of-blood-stream-infection-in-patients-with-hematological-malignancies-after-chemotherapy
#1
S Z Chen, K N Lin, M Xiao, X F Luo, Q Li, J H Ren, R Y Huang, M M Chen, Z Z Ally, T Chen, J D Yang, Jianda Hu
Objective: To investigate the distribution and resistance of pathogens isolated from blood cultures in patients with hematological malignancies after chemotherapy in Union Hospital of Fujian Medical University so as to understand the real situation of blood stream infection (BSI) and provide the basis for rational use of antibiotics in clinic. Methods: The data of 657 strains isolated from blood culture specimens of patients with hematological malignancies from January 2013 to December 2016 were collected analyzed...
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29219803/accuracy-and-reproducibility-of-the-etest-to-detect-drug-resistant-neisseria-gonorrhoeae-to-contemporary-treatment
#2
John R Papp, Marie-Claire Rowlinson, Norman P O'Connor, Jason Wholehan, Jafar H Razeq, Anita Glennen, Dapne Ware, Peter C Iwen, Lillian V Lee, Celia Hagan
PURPOSE: Neisseria gonorrhoeae is a sexually transmitted bacterial pathogen that continues to evolve to become resistant to known antibiotics. In preparing for potential emergence, the Centers for Disease Control and Prevention recommends that clinical laboratories maintain or develop protocols to assess antibiotic susceptibly for this organism. This study examines the intra-laboratory variability of using the Etest method to provide consistent MIC values for N. gonorrhoeae and also compared the results of the Etest to known agar dilution MIC values...
December 8, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29187146/determination-of-antimicrobial-susceptibility-patterns-in-staphylococcus-aureus-strains-recovered-from-patients-at-two-main-health-facilities-in-kabul-afghanistan
#3
Haji Mohammad Naimi, Hamidullah Rasekh, Ahmad Zia Noori, Mohammad Aman Bahaduri
BACKGROUND: Staphylococcus aureus (S. aureus) is a major pathogen implicated in skin and soft tissue infections, abscess in deep organs, toxin mediated diseases, respiratory tract infections, urinary tract infections, post-surgical wound infections, meningitis and many other diseases. Irresponsible and over use of antibiotics has led to an increased presence of multidrug resistant organisms and especially methicillin resistant Staphylococcus aureus (MRSA) as a major public health concern in Afghanistan...
November 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29182725/genomic-epidemiology-and-antimicrobial-resistance-of-neisseria-gonorrhoeae-in-new-zealand
#4
Robyn S Lee, Torsten Seemann, Helen Heffernan, Jason C Kwong, Anders Gonçalves da Silva, Glen P Carter, Rosemary Woodhouse, Kristin H Dyet, Dieter M Bulach, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson
Background: Antimicrobial-resistant Neisseria gonorrhoeae is a major threat to public health. No studies to date have examined the genomic epidemiology of gonorrhoea in the Western Pacific Region, where the incidence of gonorrhoea is particularly high. Methods: A population-level study of N. gonorrhoeae in New Zealand (October 2014 to May 2015). Comprehensive susceptibility testing and WGS data were obtained for 398 isolates. Relatedness was inferred using phylogenetic trees, and pairwise core SNPs...
November 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29156265/occurrence-and-fate-of-most-prescribed-antibiotics-in-different-water-environments-of-tehran-iran
#5
Roya Mirzaei, Masud Yunesian, Simin Nasseri, Mitra Gholami, Esfandiyar Jalilzadeh, Shahram Shoeibi, Alireza Mesdaghinia
The presence of most prescribed antibiotic compounds from four therapeutic classes (β-lactam, cephalosporins, macrolides, fluoroquinolones) were studied at two full-scale WWTPs, two rivers, thirteen groundwater resources, and five water treatment plants in Tehran. Analytical methodology was based on high performance liquid chromatography/tandem mass spectrometry after solid-phase extraction. Samples were collected at 33 sample locations on three sampling periods over four months from June to August 2016. None of the target antibiotics were detected in groundwater resources and water treatment plants, while seven out of nine target antibiotics were analyzed in two studied river waters as well as the influent and effluent of wastewater treatment plants at concentrations ranging from <LOQ to 926...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29104078/eucalyptus-robusta-leaves-methanolic-extract-suppresses-inflammatory-mediators-by-specifically-targeting-tlr4-tlr9-mpo-cox2-inos-and-inflammatory-cytokines-in-experimentally-induced-endometritis-in-rats
#6
Aastha Tiwari, Preeti Singh, Pooja Jaitley, Sushant Sharma, Atul Prakash, Rajesh Mandil, Soumen Choudhury, Neeraj Kumar Gangwar, Satish K Garg
ETHNOPHARMACOLOGICAL RELEVANCE: Bacterial endometritis is one of the major causes of reproductive disorders including infertility in farm animals. Antibiotics are generally used for treatment of such disorders but now a days residues of antibiotics are of great public health concern, therefore, phytoremediation is being considered as an alternative to use of antibiotics. AIM OF THE STUDY: Present study was undertaken to investigate the efficacy of Eucalyptus robusta leaves methanolic extract against endometritis along with the possible mechanism of action especially targeting inflammatory biomarkers...
November 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29062203/characterization-and-zoonotic-impact-of-shiga-toxin-producing-escherichia-coli-in-some-wild-bird-species
#7
Hanaa Mohamed Fadel, Rabab Afifi, Dheyazan Mohammed Al-Qabili
AIM: Wild birds are considered silent vectors of some zoonotic water and food borne pathogens of public health significance. Owing to the importance of Shiga toxin producing Escherichia coli (STEC) as the most pathogenic among the emerging diarrheagenic E. coli groups that can infect man; the present study was designed to detect the occurrence of STEC among wild birds in Egypt. MATERIALS AND METHODS: A total of 177 intestinal content swab samples originating from five wild bird species were investigated for the presence of E...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29044002/irrational-antibiotic-prescribing-practice-among-children-in-critical-care-of-tertiary-hospitals
#8
Mirza Tasawer Baig, Ali Akbar Sial, Ambreen Huma, Maryam Ahmed, Uzma Shahid, Nayel Syed
This study assessed the prescribing pattern of irrational use of antibiotic among children under age of 12 years in public and private sector hospitals in Pakistan. The prospective clinical evaluation of drug utilization pattern of antimicrobials from Patient Bedside File (PBF) of in-patients and Culture Sensitivity Test (CST) reports were evaluated to determine the antibiotic resistance. Two indicators recorded to assess antibiotic prescribing were; dose of prescribed antibiotic (low-dose, rational and high -dose) and Indication (valid or invalid)...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29029217/high-levels-of-susceptibility-to-new-and-older-antibiotics-in-neisseria-gonorrhoeae-isolates-from-saskatchewan-2003-15-time-to-consider-point-of-care-or-molecular-testing-for-precision-treatment
#9
Sidharath D Thakur, Paul N Levett, Gregory B Horsman, Jo-Anne R Dillon
Objectives: The antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Saskatchewan was determined retrospectively (2003-15) to ascertain temporal trends to both current and older antimicrobials used for treatment. Method: The agar dilution method was used to test the antimicrobial susceptibilities of 685 isolates to seven antibiotics. Results: Over the period, only three (0.4%) gonococcal isolates had reduced susceptibility to cefixime and/or ceftriaxone...
September 27, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29018810/renaissance-of-conventional-first-line-antibiotics-in-salmonella-enterica-clinical-isolates-assessment-of-mics-for-therapeutic-antimicrobials-in-enteric-fever-cases-from-nepal
#10
Puspa Raj Khanal, Deepa Satyal, Anjeela Bhetwal, Anjila Maharjan, Shreena Shakya, Snehika Tandukar, Narayan Prasad Parajuli
Enteric fever caused by Salmonella enterica is a life-threatening systemic illness of gastrointestinal tract especially in tropical countries. Antimicrobial therapy is generally indicated but resistance towards commonly used antibiotics has limited their therapeutic usefulness. Therefore, we aimed to determine the antimicrobial susceptibility pattern by minimum inhibitory concentration method of common therapeutic regimens against Salmonella enterica from enteric fever clinical cases. Salmonella enterica clinical isolates recovered from the patients with suspected enteric fever whose blood samples were submitted to microbiology laboratory of Manmohan Memorial Community Hospital, Kathmandu, from March 2016 to August 2016, were studied...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28976065/probing-the-interaction-of-cephalosporin-with-bovine-serum-albumin-a-structural-and-comparative-perspective
#11
Li-Yang Cheng, Cheng-Zhang Yang, Hui-Zi Li, Min Li, Ai-Min Bai, Yu Ouyang, Yan-Jun Hu
Cephalosporins belong the largest class of antibiotics used in the treatment of a wide range of infectious diseases caused by susceptible organisms. In the present study, we chose two typical antibiotics cefalexin/cefixime based on their structure, and investigated the interaction of cephalexin/cefixime with bovine serum albumin (BSA) using UV-vis absorption spectra, fluorescence spectroscopy, circular dichroism (CD) spectroscopy and molecular modeling approaches. Spectroscopic experiments revealed the formation of a BSA - cefalexin/cefixime complex...
October 4, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28919603/current-trends-of-using-antimicrobials-at-obstetrics-and-gynaecology-department-in-a-tertiary-care-hospital
#12
M M Islam, S K Saha, S Saha, U A Wahid, R R Gomes, K S Ahmed, A N Naushad, S E Suchi, C Saha, D Mondal
This cross-sectional descriptive study was done to analyse the current trends of using antimicrobials in various surgical procedures at Obstetrics and Gynaecology department in Mymensingh Medical College Hospital, Mymensingh from July 2014 to June 2015. Among 300 postoperative obstetrics and gynaecological surgery cases, samples were selected as non-random purposive selection method where pattern of using antimicrobials were analysed by SPSS method 20.1 versions. The incidence of antimicrobial resistance is on continued rise with a threat to return to the pre-antibiotic era...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28893203/overall-low-extended-spectrum-cephalosporin-resistance-but-high-azithromycin-resistance-in-neisseria-gonorrhoeae-in-24-european-countries-2015
#13
Michelle J Cole, Gianfranco Spiteri, Susanne Jacobsson, Neil Woodford, Francesco Tripodo, Andrew J Amato-Gauci, Magnus Unemo
BACKGROUND: Surveillance of Neisseria gonorrhoeae antimicrobial susceptibility in Europe is performed through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP), which additionally provides data to inform the European gonorrhoea treatment guideline; currently recommending ceftriaxone 500 mg plus azithromycin 2 g as first-line therapy. We present antimicrobial susceptibility data from 24 European countries in 2015, linked to epidemiological data of patients, and compare the results to Euro-GASP data from previous years...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28876284/in-vitro-synergy-testing-of-gentamicin-an-old-drug-suggested-as-future-treatment-option-for-gonorrhoea-in-combination-with-six-other-antimicrobials-against-multidrug-resistant-neisseria-gonorrhoeae-strains
#14
Vikram Singh, Manju Bala, Aradhana Bhargava, Monika Kakran, Ravi Bhatnagar
BACKGROUND: Emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Neisseria gonorrhoeae is a serious concern and combination therapy has been recommended to delay the onset of treatment failures. Gentamicin, an old and inexpensive antibiotic, is recommended in combination with azithromycin for treatment failures cases with the first-line regimen as per the latest Centers for Disease Control and Prevention sexually transmitted disease treatment guidelines. However, not much literature is available on in vitro and in vivo efficacy of this combination...
August 30, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28844213/effects-of-rhubarb-rheum-ribes-l-syrup-on-dysenteric-diarrhea-in-children-a-randomized-double-blind-placebo-controlled-trial
#15
Ali Khiveh, Mohammad Hashem Hashempur, Mehrdad Shakiba, Mohammad Hassan Lotfi, Afsaneh Shakeri, SeidKazem Kazemeini, Zohre Mousavi, Marzie Jabbari, Mohammad Kamalinejad, Majid Emtiazy
BACKGROUND: Rheum ribes L. is a plant native to China, Iran, Turkey, India, and a few other countries. Antidiarrheal activity is considered to be one of its important properties according to various systems of traditional medicine. An increasing rate of bacterial resistance to antibiotics has led to treatment failure in some cases of shigellosis in children, and underlines a need for safe, efficient and valid options. OBJECTIVE: The purpose of this study is to evaluate the efficacy of R...
September 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28838340/isolation-identification-and-characterization-of-morganella-morganii-from-naja-naja-atra-in-beijing-china
#16
H-F Wang, L-Y Du, J Luo, H-X He
Morganella morganii is an important opportunistic human pathogen and belongs to the family of Enterobacteriaceae. Although it is widely distribution, it only be considered a rare cause of human infections. We report the isolate of M. morganii from Naja naja atra following infections of heart, lung and liver. Seven strains were confirmed using 16S rDNA amplified and sequences. Antimicrobial susceptibility testing of M. morganii isolates demonstrated ubiquitous resistance to ampicillin, amoxicillin/clavulanic acid, cefazolin, cephalothin, sulfamethoxazole/trimethoprim, sulfamethoxazole et al...
August 15, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28822261/revelation-of-susceptibility-differences-due-to-hg-ii-accumulation-in-streptococcus-pyogenes-against-cx-agnps-and-cefixime-by-atomic-force-microscopy
#17
Wasia Rasheed, Muhammad Raza Shah, Samina Perveen, Shakil Ahmed, Sami Uzzaman
Solution based method for the formation of chemically modified silver nanoparticles (CX-AgNPs) using Cefixime as stabilizing and reducing agent was developed. The CX-AgNPs were characterized by AFM, UV-visible, FT-IR and MALDI-TOF MS. Bactericidal efficiency of CX-AgNPs and Cefixime against Streptococcus pyogenes was evaluated. Afterwards, susceptibility differences of Streptococcus pyogenes due to accumulation of Hg(II) against CX-AgNPs and Cefixime were estimated and validated through Atomic force microscopy...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28759854/analytical-method-development-and-validation-of-spectrofluorimetric-and-spectrophotometric-determination-of-some-antimicrobial-drugs-in-their-pharmaceuticals
#18
F Ibrahim, M E K Wahba, G Magdy
In this study, three novel, sensitive, simple and validated spectrophotometric and spectrofluorimetric methods have been proposed for estimation of some important antimicrobial drugs. The first two methods have been proposed for estimation of two important third-generation cephalosporin antibiotics namely, cefixime and cefdinir. Both methods were based on condensation of the primary amino group of the studied drugs with acetyl acetone and formaldehyde in acidic medium. The resulting products were measured by spectrophotometric (Method I) and spectrofluorimetric (Method II) tools...
January 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28755874/antibiofilm-potential-of-synthetic-2-amino-5-chlorobenzophenone-schiff-bases-and-its-confirmation-through-fluorescence-microscopy
#19
Arshia, Anum Khalid Khan, Khalid Mohammed Khan, Ayaz Ahmed, Muhammad Taha, Shahnaz Perveen
Antibacterial/antibiofilm potential of microwave-assisted synthetic thirty-three 2-amino-5-chloro benzophenone Schiff bases have been carried out against four bacterial strains i.e. Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus and Streptococcus mutans. Among them compounds 5, 6, 8, 9, 14, 16, 22, 24, 26, and 30-32 showed antibiofilm activities against isolates at less than 100 μg/ml concentrations. These compounds showed enhanced antibiofilm activity against S. aureus as compared to cefixime used as control...
July 26, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28741188/-sexually-transmitted-infections-in-germany-the-current-epidemiological-situation
#20
Viviane Bremer, Sandra Dudareva-Vizule, Susanne Buder, Matthias An der Heiden, Klaus Jansen
Sexually transmitted infections (STIs) can impair sexual health. Surveillance and study data were used to provide an overview over STIs in Germany. We estimated 3900 new HIV diagnoses in 2015. Of newly diagnosed infections, 57% were attributed to men who have sex with men (MSM). It was further estimated that there were 3200 new HIV infections and 84,700 people living with HIV in 2015. A total of 6834 syphilis infections were recorded in 2015, which corresponds to an increase of 149% since 2009. The incidence in men was 16-times higher than in women...
July 24, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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