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https://www.readbyqxmd.com/read/27904747/comparing-the-disk-diffusion-and-agar-dilution-tests-for-neisseria-gonorrhoeae-antimicrobial-susceptibility-testing
#1
Hsi Liu, Thomas H Taylor, Kevin Pettus, Steve Johnson, John R Papp, David Trees
BACKGROUND: We assessed the validity of testing for antimicrobial susceptibility of clinical and mutant Neisseria gonorrhoeae (GC) isolates by disk diffusion in comparison to agar dilution, and Etest® (bioMerieux, France), respectively, for three third generation extended spectrum cephalosporins (ESC): ceftriaxone (CRO), cefixime (CFX), and cefpodoxime (CPD). METHODS: One hundred and five clinical isolates and ten laboratory-mutants were tested following Clinical Laboratory Standard Institute (CLSI) and manufacturer's standards for each of the three methods...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27898572/sexually-transmitted-infections-and-associated-risk-factors-among-street-based-and-residence-based-female-sex-workers-in-dhaka-bangladesh
#2
Rasheda Khanam, Masud Reza, Dilruba Ahmed, Mustafizur Rahman, M Shah Alam, Salima Sultana, Anadil Alam, Sharful I Khan, Kenneth H Mayer, Tasnim Azim
BACKGROUND: Female sex workers (FSWs) in Bangladesh remain at elevated risk of sexually transmitted infections (STIs) although the human immunodeficiency virus (HIV) prevalence among them is low. Recent information on the burden and etiological diagnosis of STIs among them has been lacking. This study examines prevalence and risk behaviors of selected STIs among FSWs in Dhaka in 2014. METHODS: Between August and October 2014, a cross-sectional study was conducted among street-based and residence-based FSWs receiving HIV prevention services at 24 drop in centers in Dhaka...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27890419/in-vitro-activity-of-tigecycline-alone-and-antimicrobial-combinations-against-clinical-neisseria-gonorrhoeae-isolates
#3
Hyukmin Lee, Hyunsoo Kim, Young Hee Seo, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee, Younsop Chong
In this study, we determined the in vitro activity of various combinations of antimicrobial agents against 54 Neisseria gonorrhoeae isolates. The combined activity of ceftriaxone (CRO) and azithromycin (AZM), CRO and doxycycline (DOX), CRO and spectinomycin (SPT), cefixime (CFX) and AZM, CFX and DOX, and CFX and SPT was determined using a checkerboard method. The fractional inhibitory concentration index (FICI) values for all combinations were either additive or indifferent, and no synergistic or antagonistic effects were found...
October 25, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27887651/studies-on-the-therapeutic-effect-of-propolis-along-with-standard-antibacterial-drug-in-salmonella-enterica-serovar-typhimurium-infected-balb-c-mice
#4
Preeti Kalia, Neelima R Kumar, Kusum Harjai
BACKGROUND: Antibiotic resistance is an emerging public health problem. Centers for Disease Control and Prevention (CDC) has described antibiotic resistance as one of the world's most pressing health problems in 21(st) century. WHO rated antibiotic resistance as "one of the three greatest threats to human health". One important strategy employed to overcome this resistance is the use of combination of drugs. Many plants, natural extracts have been shown to exhibit synergistic response with standard drugs against microorganisms...
November 25, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27822958/double-tailed-acyl-glycoside-niosomal-nanocarrier-for-enhanced-oral-bioavailability-of-cefixime
#5
Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdul Sadiq, Imdad Ali, Farid Ahmed, Waqas Nawaz
Novel, safe, efficient, and cost effective surfactants from renewable resources has attracted attention for enhancing solubility and bioavailability of hydrophobic dugs. We report the synthesis, characterization, and biocompatibility of a novel non-ionic acyl glycoside double-tailed surfactant for niosomal drug delivery system. Structure of the surfactant was confirmed by (1)H NMR and mass spectroscopy. Applications of surfactant in niosomal drug delivery were explored using Cefixime as model. The shape, size, and polydispersity index (PDI) of drug loaded vesicles were investigated with atomic force microscope (AFM) and dynamic light scattering (DLS)...
November 8, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27803470/synthesis-and-in-vitro-antibacterial-evaluation-of-novel-4-substituted-1-menthyl-1-2-3-triazoles
#6
Pooneh Khaligh, Peyman Salehi, Morteza Bararjanian, Atousa Aliahmadi, Hamid Reza Khavasi, Samad Nejad-Ebrahimi
Menthyl 1,4-disubstituted 1,2,3-triazole derivatives of hydroxybenzaldehydes, phenols and bile acids were synthesized via click chemistry. The novel synthesized compounds were evaluated for their in vitro antibacterial activity against Enterococcus faecium, and Staphylococcus aureus as Gram-positive bacteria. Some derivatives illustrated strong inhibitory effect against E. faecium with the minimum inhibitory concentration (MIC) values ranged from 1-3 µM, where cefixime as a positive control revealed MIC value of 35 µM...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27758727/differences-in-neisseria-gonorrhoeae-population-structure-and-antimicrobial-resistance-pattern-between-men-who-have-sex-with-men-and-heterosexuals
#7
J Serra-Pladevall, M J Barberá, A E Callarisa, R Bartolomé-Comas, A Andreu
This study compared the antimicrobial susceptibility and genotypes of strains of Neisseria gonorrhoeae isolated from men who have sex with men (MSM) and from heterosexuals. One hundred and eleven strains were characterized from 107 patients, comprising 57 strains from 54 heterosexuals and 54 strains from 53 MSM. Antimicrobial resistance rates were higher in strains from heterosexual patients, with resistance to cefixime (P = 0·0159) and ciprofloxacin (P = 0·002) being significantly higher. Typing by N. gonorrhoeae multi-antigen sequence typing (NG-MAST) showed that the most prevalent sequence types (ST) and genogroups (G) respectively were ST2400, ST2992, and ST5793, and G1407, G2992, and G2400...
October 19, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27733802/occurrence-and-characteristics-of-extended-spectrum-%C3%AE-lactamases-producing-escherichia-coli-in-foods-of-animal-origin-and-human-clinical-samples-in-chhattisgarh-india
#8
Bhoomika, Sanjay Shakya, Anil Patyal, Nitin Eknath Gade
AIM: To assess the prevalence of antimicrobial resistance producing extended-spectrum β-lactamases (ESBL) (blaTEM, blaSHV, and blaCTX-M) genes in Escherichia coli isolated from chicken meat, chevon meat, raw milk, and human urine and stool samples collected from tribal districts of Chhattisgarh, viz., Jagdalpur, Dantewada, Kondagaon, and Kanker. MATERIALS AND METHODS: A total of 330 samples, comprising 98 chicken meat, 82 chevon meat, 90 raw milk, and 60 human urine and stool samples, were processed for isolation of E...
September 2016: Veterinary World
https://www.readbyqxmd.com/read/27668907/recurrent-complicated-urinary-tract-infection-due-to-rare-pathogen-sphingomonas-paucimobilis-contamination-or-real-deal
#9
Tulin Demir, Mumtaz Dadali
Sphingomonas paucimobilis is an aerobic, oxidase-positive, yellow-pigmented, non-fermentative, Gram-negative opportunistic pathogen that rarely causes infections in humans. It is commonly found in nosocomial environments and, despite its low clinical virulence, it can be responsible for several different infections especially among patients with underlying disease. Here we describe a clinical case of a 46-year-old male paraplegic patient with a history of neurogenic bladder due to insulin-dependent diabetes mellitus and renal failure who was admitted to the urology clinic of a university hospital in Kirsehir, Turkey, with the complaints of urinary tract infection (UTI) including fever, chills, dysuria, abdominal and back pain...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27646968/emerging-azithromycin-resistance-among-the-neisseria-gonorrhoeae-strains-isolated-in-hungary
#10
Alexandra Brunner, Eva Nemes-Nikodem, Csaba Jeney, Dora Szabo, Marta Marschalko, Sarolta Karpati, Eszter Ostorhazi
BACKGROUND: In the 1990s, azithromycin became the drug of choice for many infectious diseases but emerging resistance to the drug has only been reported in the last decade. In the last 5 years, the National Neisseria gonorrhoeae Reference Laboratory of Hungary (NNGRLH) has also observed an increased number of N. gonorrhoeae strains resistant to azithromycin. The aim of this study was to determine the most frequent sequence types (ST) of N. gonorrhoeae related to elevated levels of azithromycin MIC (minimal inhibitory concentration)...
2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27642826/adsorption-of-cefixime-from-aqueous-solutions-using-modified-hardened-paste-of-portland-cement-by-perlite-optimization-by-taguchi-method
#11
Mohammad Hossein Rasoulifard, Soghra Khanmohammadi, Azam Heidari
In the present study, we have used a simple and cost-effective removal technique by a commercially available Fe-Al-SiO2 containing complex material (hardened paste of Portland cement (HPPC)). The adsorbing performance of HPPC and modified HPPC with perlite for removal of cefixime from aqueous solutions was investigated comparatively by using batch adsorption studies. HPPC has been selected because of the main advantages such as high efficiency, simple separation of sludge, low-cost and abundant availability...
September 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27639378/time-kill-curve-analysis-and-pharmacodynamic-modelling-for-in-vitro-evaluation-of-antimicrobials-against-neisseria-gonorrhoeae
#12
Sunniva Foerster, Magnus Unemo, Lucy J Hathaway, Nicola Low, Christian L Althaus
BACKGROUND: Gonorrhoea is a sexually transmitted infection caused by the Gram-negative bacterium Neisseria gonorrhoeae. Resistance to first-line empirical monotherapy has emerged, so robust methods are needed to evaluate the activity of existing and novel antimicrobials against the bacterium. Pharmacodynamic models describing the relationship between the concentration of antimicrobials and the minimum growth rate of the bacteria provide more detailed information than the MIC only. RESULTS: In this study, a novel standardised in vitro time-kill curve assay was developed...
2016: BMC Microbiology
https://www.readbyqxmd.com/read/27638945/genomic-epidemiology-of-gonococcal-resistance-to-extended-spectrum-cephalosporins-macrolides-and-fluoroquinolones-in-the-united-states-2000-2013
#13
Yonatan H Grad, Simon R Harris, Robert D Kirkcaldy, Anna G Green, Debora S Marks, Stephen D Bentley, David Trees, Marc Lipsitch
BACKGROUND:  Treatment of Neisseria gonorrhoeae infection is empirical and based on population-wide susceptibilities. Increasing antimicrobial resistance underscores the potential importance of rapid diagnostic tests, including sequence-based tests, to guide therapy. However, the usefulness of sequence-based diagnostic tests depends on the prevalence and dynamics of the resistance mechanisms. METHODS:  We define the prevalence and dynamics of resistance markers to extended-spectrum cephalosporins, macrolides, and fluoroquinolones in 1102 resistant and susceptible clinical N...
November 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27632642/antimicrobial-resistance-of-neisseria-gonorrhoeae-isolates-in-south-west-germany-2004-to-2015-increasing-minimal-inhibitory-concentrations-of-tetracycline-but-no-resistance-to-third-generation-cephalosporins
#14
Thomas Regnath, Thomas Mertes, Ralf Ignatius
Increasing antimicrobial resistance of Neisseria gonorrhoeae, particularly to third-generation cephalosporins, has been reported in many countries. We examined the susceptibility (determined by Etest and evaluated using the breakpoints of the European Committee on Antimicrobial Susceptibility Testing) of 434 N. gonorrhoeae isolates collected from 107 female and 327 male patients in Stuttgart, south-west Germany, between 2004 and 2015. During the study period, high proportions of isolates were resistant to ciprofloxacin (70...
September 8, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27626188/gonorrhea-in-indonesia-high-prevalence-of-asymptomatic-urogenital-gonorrhea-but-no-circulating-extended-spectrum-cephalosporins-resistant-neisseria-gonorrhoeae-strains-in-jakarta-yogyakarta-and-denpasar-indonesia
#15
I Putu Yuda Hananta, Alje P van Dam, Sylvia Maria Bruisten, Maarten Franciscus Schim van der Loeff, Hardyanto Soebono, Henry John Christiaan de Vries
BACKGROUND: Little is known about the epidemiology of asymptomatic urogenital gonorrhea and antimicrobial susceptibility of Neisseria gonorrhoeae (NG) strains circulating in Indonesia. We studied these issues in 3 large Indonesian cities. METHODS: In 2014, participants were recruited from sexually transmitted infection clinics and through outreach in Jakarta, Yogyakarta, and Denpasar. Neisseria gonorrhoeae detection in genital specimens was performed with NG-qPCR at the Public Health Service in Amsterdam...
October 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27621914/campylobacter-jejuni-bacteremia-in-a-patient-with-acute-lymphocytic-leukemia
#16
Mojtaba Anvarinejad, Maneli Amin Shahidi, Gholam Reza Pouladfar, Mohammad Ali Dehyadegari, Jalal Mardaneh
INTRODUCTION: Campylobacter jejuni is a slender, motile, non-spore-forming, helical-shaped, gram-negative bacterium. It is one of the most common causes of human gastroenteritis in the world. The aim of this study was to present a patient with acute lymphocytic leukemia (ALL), who was infected with Campylobacter jejuni. CASE PRESENTATION: We describe the medical records of a pediatric ALL patient with bacteremia caused by C. jejuni, who was diagnosed at Amir hospital, Shiraz, Iran...
June 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27608951/biochemical-synthesis-of-silver-nanoprticles-using-filamentous-fungi-penicillium-decumbens-mtcc-2494-and-its-efficacy-against-a-549-lung-cancer-cell-line
#17
Shahnaz Majeed, Mohd Syafiq Bin Abdullah, Gouri Kumar Dash, Mohammed Tahir Ansari, Anima Nanda
Biosynthesis of silver and other metallic nanoparticles is one of the emerging research area in the field of science and technology due to their potentiality, especially in the field of nano-biotechnology and biomedical sciences in order to develop nanomedicine. In our present study, Penicillium decumbens (MTCC-2494) was brought from Institute of Microbial Technology (IMTECH) Chandigarh and employed for extracellular biological synthesis of silver nanoparticles. Ag-NPs formation was appeared with a dark brown color inside the conical flask...
August 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27580580/gonococcal-antimicrobial-susceptibility-and-prevalence-of-blatem-1-blatem-135-genes-in-thailand
#18
Chanwit Tribuddharat, Pintip Pongpech, Angkana Charoenwatanachokchai, Somchai Lokpichart, Somporn Srifuengfung, Suthatta Sonprasert
We studied antimicrobial susceptibility and the current rates of blaTEM-1 and blaTEM-135. Neisseria gonorrhoeae 370 isolates were tested by using disk diffusion method and found 100% susceptible to cefixime, ceftriaxone, cefotaxime, ceftazidime, cefepime, spectinomycin and azithromycin. They were resistant to penicillin (85.7%), ciprofloxacin (88.0%), ofloxacin (97.4%), and tetracycline (89.1%). Penicillinase-producing N. gonorrhoeae (PPNG) was 83.8% which 70.0% was further identified as PPNG plus tetracycline resistant N...
August 31, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27530999/draft-genome-sequence-of-blatem-1-mediated-cephalosporin-resistant-salmonella-enterica-serovar-typhi-from-bloodstream-infection
#19
Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Baby Abirami Shankar, Elakkiya Munusamy, Shalini Anandan, Balaji Veeraraghavan
Enteric fever is a major cause of concern in developing countries across the globe. The primary choice of antibiotics remains fluoroquinolones, followed by cephalosporins. Resistance to third-generation cephalosporins is rarely reported in Salmonella enterica serovar Typhi. This study reports the whole genome sequence of an S. Typhi isolate resistant to cefixime [minimum inhibitory concentration (MIC)=512μg/mL] by microbroth dilution. Interestingly, the isolate was negative for the cephalosporin resistance gene blaCTX-M by PCR, which is a known mechanism for higher cephalosporin resistance...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27498443/comparison-of-cefixime-and-amoxicillin-plus-metronidazole-in-the-treatment-of-chronic-periodontitis
#20
RANDOMIZED CONTROLLED TRIAL
Smiljka Dukić, Stevo Matijević, Dragana Daković, Tatjana Cutović
BACKGROUND/AIM: Despite significant advances in current medicine and improvement of overall health education, chronic periodontitis is still a widespread disease. Losing teeth is the most serious complication of this particular illness. The aim of this study was to examine patients with chronic periodontitis in order to evaluate the efficacy of non-surgical therapy and combination of amoxicillin and metronidazole compared with cefixime, which has not been so far used for the treatment of this disease...
June 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
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