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https://www.readbyqxmd.com/read/29674407/quality-assurance-for-antimicrobial-susceptibility-testing-of-neisseria-gonorrhoeae-in-latin-american-and-caribbean-countries-2013-2015
#1
Pam Sawatzky, Irene Martin, Patricia Galarza, Marıa Elena Trigoso Carvallo, Pamela Araya Rodriguez, Olga Marina Sanabria Cruz, Alina Llop Hernandez, Mario Fabian Martinez, Graciela Borthagaray, Daisy Payares, José E Moreno, Marina Chiappe, Aura Helena Corredor, Sidharath Dev Thakur, Jo-Anne R Dillon
OBJECTIVES: A Neisseria gonorrhoeae antimicrobial susceptibility quality control comparison programme was re-established in Latin America and the Caribbean to ensure antimicrobial susceptibility data produced from the region are comparable nationally and internationally. METHODS: Three panels, consisting of N. gonorrhoeae isolates comprising reference strains and other characterised isolates were sent to 11 participating laboratories between 2013 and 2015. Antimicrobial susceptibilities for these isolates were determined using agar dilution, Etest or disc diffusion methods...
April 19, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29625943/drug-utilization-and-prescribing-pattern-of-antibiotics-in-a-tertiary-care-setups-trends-and-practices
#2
Huma Ali, Farya Zafar, Shazia Alam, Anwar Ejaz Beg, Rabia Bushra, Ammara Manzoor, Ghazala R Naqvi, Riffat Yasmeen, Yousra Shafiq, Anum Tariq, Saba Zubair, Saima Saleem
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29624558/a-phase-1-pharmacokinetic-and-safety-study-of-extended-duration-high-dose-cefixime-for-cephalosporin-resistant-neisseria-gonorrhoeae-in-the-pharynx
#3
Lindley A Barbee, Seema U Nayak, Jeffrey L Blumer, Mary Ann O'Riordan, Wesley Gray, Jonathan M Zenilman, Matthew R Golden, J McLeod Griffiss
BACKGROUND: There are no fully oral recommended treatment regimens for gonorrhea. Inadequately treated pharyngeal gonococcal infections are a likely reservoir for transmission and development of antimicrobial resistance. We sought to determine an oral cefixime dosing regimen that would theoretically treat pharyngeal infections by gonococci with MICs 0.5μg/mL. METHODS: We conducted an open label, non-randomized, Phase I pharmacokinetic and safety study of cefixime in 25 healthy male and female volunteers divided into four dosing cohorts (Cohort A, 400 mg; Cohort B, 800 mg; Cohort C, 1200 mg; and Cohort D, 800 mg q8h x 3 doses [total dose 2400mg]) with a target serum concentration of ≥2...
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29568806/antibiotic-resistance-patterns-of-urinary-tract-pathogens-in-turkish-children
#4
Suzan Gunduz, Hatice Uludağ Altun
Background: Knowledge of local antimicrobial resistance patterns is essential for evidence- based empirical antibiotic prescribing. We aimed to investigate the distribution and changes in causative agents of urinary tract infections in children and the resistance rates, and to recommend the most appropriate antibiotics. Methods: In this retrospective study, we evaluated causative agents and antimicrobial resistance in urine isolates from the positive community from September 2014 to April 2016 in a single hospital in Ankara, Turkey...
2018: Global health research and policy
https://www.readbyqxmd.com/read/29509792/in-vitro-efficacy-of-21-dual-antimicrobial-combinations-comprising-novel-and-currently-recommended-combinations-for-treatment-of-drug-resistant-gonorrhoea-in-future-era
#5
Vikram Singh, Manju Bala, Aradhana Bhargava, Monika Kakran, Ravi Bhatnagar
BACKGROUND: Recent WHO guidelines recommend dual therapy with ceftriaxone or cefixime plus azithromycin for gonorrhea. Azithromycin in combination with gentamicin or spectinomycin has been recommended in treatment failure cases. Due to emergence of multi-drug resistant (MDR) and extensively-drug resistant (XDR) Neisseria gonorrhoeae strains, it is important to look for efficacy of these combinations and also of others that might be used in future. Therefore, we aimed to evaluate in vitro synergy of 21 dual combinations including current and alternative WHO recommended treatment regimens and other dual combinations...
2018: PloS One
https://www.readbyqxmd.com/read/29503075/antibiotic-prophylaxis-in-transarterial-chemoembolization-of-hepatocellular-carcinoma
#6
Mohamed Awad Mansour, Mohamed Omar Khalifa
BACKGROUND AND STUDY AIMS: Transarterial chemoembolization remains a common treatment option in unresectable hepatocellular carcinoma. However, protocols for pre- and post-procedure care and the role of antibiotic prophylaxis have not been evaluated. The aim of this work was to compare 3 different groups of prophylactic antibiotics in patients undergoing chemoembolization and to compare the efficacy of intravenous versus oral route. PATIENTS AND METHODS: 180 hepatocellular carcinoma patients undergoing transarterial chemoembolization were selected...
March 1, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29477549/antimicrobial-susceptibilities-and-molecular-typing-of-neisseria-gonorrhoeae-isolates-at-a-medical-centre-in-taiwan-2001-2013-with-an-emphasis-on-high-rate-of-azithromycin-resistance-among-the-isolates
#7
Yen-Hung Liu, Yu-Tsung Huang, Chun-Hsing Liao, Po-Ren Hsueh
A high prevalence of gonococcal resistance to various antimicrobials as well as Neisseria gonorrhoeae isolates exhibiting resistance to extended-spectrum cephalosporins have been reported in the past few decades. A total of 226 N. gonorrhoeae isolates obtained from the National Taiwan University Hospital from 2001 to 2013 were evaluated. The minimum inhibitory concentrations (MICs) of the isolates to antimicrobials were determined by the agar dilution method and interpreted using the 2017 clinical breakpoints or epidemiological cut-off values recommended by the Clinical and Laboratory Standards Institute and European Committee on Antimicrobial Susceptibility Testing (EUCAST)...
February 22, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29465747/antibiotics-for-treating-gonorrhoea-in-pregnancy
#8
REVIEW
Gabriella Comunián-Carrasco, Guiomar E Peña-Martí, Arturo J Martí-Carvajal
BACKGROUND: Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. This review updates and replaces an earlier Cochrane Review on antibiotics for treating this infectious condition...
February 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29459597/prevalence-of-metallo-%C3%AE-lactamase-producing-non-fermentative-pseudomonas-species-from-clinical-isolates-in-dhaka-bangladesh
#9
M N Islam, D Ahmed, M A Hossain, C R Ahsan, M Yasmin
Antimicrobial drug resistance, a global concern, has been increasing unpredictably in microorganism causing human infections specially among Gram negative non-fermenting Pseudomonas spp. Carbapenems, a beta lactam antibiotics, are the most potent and effective drug usually kept reserved for treating the multi-drug resistant Psedomonas spp and other infections caused by organisms producing Extended Spectrum Beta Lactamase (ESBL) and AmpC. Clinical utility of carbapenem will reduce when resistant bacteria evolve due to production of carbapenem hydrolyzing Metallo-β-lactamase (MBL) which confers high-level resistance to all beta-lactam antibiotics except aztreonam...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29432657/clinical-profile-antibiotic-susceptibility-pattern-of-bacterial-isolates-and-factors-associated-with-complications-in-culture-proven-typhoid-patients-admitted-to-an-urban-hospital-in-bangladesh
#10
Halima Khatun, Shoeb Bin Islam, Nurun Nahar Naila, Syed Aminul Islam, Baitun Nahar, Md Nur Haque Alam, Tahmeed Ahmed
OBJECTIVES: Typhoid fever is one of the major causes of morbidity and mortality in typhoid endemic countries like Bangladesh. However, data on the clinical and microbiological profile as well as factors associated with complications of typhoid in Bangladesh are scarce. We intended to characterize the clinical and microbiological profile of culture-proven typhoid fever and to identify factors associated with complications. METHODOLOGY: Retrospective analysis of clinical data from 431 patients with culture-confirmed typhoid fever admitted to Dhaka hospital of International Centre for Diarrhoeal Disease Research, Bangladesh, between January 2010 and December 2014...
February 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29394396/prevalence-of-and-factors-associated-with-mdr-neisseria-gonorrhoeae-in-england-and-wales-between-2004-and-2015-analysis-of-annual-cross-sectional-surveillance-surveys
#11
Soazig Clifton, Hikaru Bolt, Hamish Mohammed, Katy Town, Martina Furegato, Michelle Cole, Oona Campbell, Helen Fifer, Gwenda Hughes
Objectives: To describe trends in prevalence, susceptibility profile and risk factors for MDR Neisseria gonorrhoeae (MDR-NG) in England and Wales. Methods: Isolates from 16 242 gonorrhoea episodes at sexual health clinics within the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) underwent antimicrobial susceptibility testing. MDR-NG was defined as resistance to ceftriaxone, cefixime or azithromycin, plus at least two of penicillin, ciprofloxacin and spectinomycin...
January 30, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29370234/febrile-urinary-tract-infection-due-to-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-children-a-french-prospective-multicenter-study
#12
Fouad Madhi, Camille Jung, Sandra Timsit, Corinne Levy, Sandra Biscardi, Mathie Lorrot, Emmanuel Grimprel, Laure Hees, Irina Craiu, Aurelien Galerne, François Dubos, Emmanuel Cixous, Véronique Hentgen, Stéphane Béchet, Stéphane Bonacorsi, Robert Cohen
OBJECTIVES: To assess the management of febrile urinary-tract infection (FUTIs) due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) in children, the Pediatric Infectious Diseases Group of the French Pediatric Society set up an active surveillance network in pediatric centers across France in 2014. MATERIALS AND METHODS: We prospectively analysed data from 2014 to 2016 for all children < 18 years old who received antibiotic treatment for FUTI due to ESBL-E in 24 pediatric centers...
2018: PloS One
https://www.readbyqxmd.com/read/29354364/phylogeny-novel-bacterial-lineage-and-enzymatic-potential-of-haloalkaliphilic-bacteria-from-the-saline-coastal-desert-of-little-rann-of-kutch-gujarat-india
#13
Hitarth B Bhatt, Sangeeta D Gohel, Satya P Singh
This report describes cultivation-dependent diversity, phylogeny and enzymatic potential of the haloalkaliphilic bacteria isolated from the unvegetated desert soil of yet unexplored, saline desert of Little Rann of Kutch (LRK), India. The LRK is a unique ecosystem displaying a combination of Dry Rann and Wet Rann. A total of 25 bacteria were isolated and characterized on the basis of colony morphology, biochemical profile, sugar utilization, secretion of the extracellular enzymes and antibiotic sensitivity...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29345462/fluorescent-zn-pdc-tb3-coordination-polymer-nanostructure-a-candidate-for-highly-selective-detections-of-cefixime-antibiotic-and-acetone-in-aqueous-system
#14
Hong Pan, Sufan Wang, Xiaoyao Dao, Yonghong Ni
Tb3+-doped zinc-based coordination polymer nanospindle bundles (Zn-PDC/Tb3+, or [Zn(2,5-PDC)(H2O)2]·H2O/Tb3+) were synthesized by a simple solution precipitation route at room temperature, employing Zn(NO3)2, Tb(NO3)3, and 2,5-Na2PDC as the initial reactants, and a mixture of water and ethanol with the volume ratio of 10:10 as the solvent. The as-obtained nanostructures presented strong fluorescent emission under the excitation of 298 nm light, which was attributed to the characteristic emission of the Tb3+ ion...
January 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29343220/antimicrobial-resistance-of-neisseria-gonorrhoeae-in-germany-low-levels-of-cephalosporin-resistance-but-high-azithromycin-resistance
#15
Susanne Buder, Sandra Dudareva, Klaus Jansen, Anna Loenenbach, Sergejs Nikisins, Andrea Sailer, Eva Guhl, Peter K Kohl, Viviane Bremer
BACKGROUND: The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea. Many of the previously effective therapeutic agents are no longer viable. Because N. gonorrhoeae infections are not reportable in Germany, only limited data on disease epidemiology and antimicrobial susceptibility patterns are available. The Gonococcal Resistance Network (GORENET) is a surveillance project to monitor trends in the antimicrobial susceptibility of N...
January 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29339130/fixed-drug-eruption-related-to-cefixime-in-an-adolescent-case
#16
İlknur Kulhas Celik, Betul Buyuktiryaki, Emine Dibek Misirlioglu, Ezgi Hasbek, Can Naci Kocabas
No abstract text is available yet for this article.
January 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29311079/neisseria-cinerea-with-high-ceftriaxone-mic-is-a-source-of-ceftriaxone-and-cefixime-resistance-mediating-pena-sequences-in-neisseria-gonorrhoeae
#17
Gene Igawa, Yuka Yamagishi, Ken-Ichi Lee, Misato Dorin, Ken Shimuta, Hiroyuki Suematsu, Shu-Ichi Nakayama, Hiroshige Mikamo, Magnus Unemo, Makoto Ohnishi
Mosaic penA alleles have caused most of the cephalosporin resistance in Neisseria gonorrhoeae , but their evolution is mostly unknown. The penA gene from Neisseria cinerea strain AM1601 (ceftriaxone MIC, 1.0 μg/ml) caused ceftriaxone resistance (MIC, 1 μg/ml) in a ceftriaxone-susceptible gonococcal strain. The 3'-terminal half of AM1601 penA was almost identical to that of the ceftriaxone-resistant gonococcal GU140106 and FC428 strains. N. cinerea can serve as a reservoir of ceftriaxone resistance-mediating penA sequences that can be transferred to gonococci...
March 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29302147/current-trends-of-drug-resistance-patterns-of-acinetobacter-baumannii-infection-in-blood-transfusion-dependent-thalassemia-patients
#18
Suhail Ahmed Almani, Ali Naseer, Sanjay Kumar Maheshwari, Pir Maroof, Raza Naseer, Haji Khan Khoharo
Objective: The present study aimed to evaluate the current trends of drug resistance patterns of Acinetobacter baumannii infection in blood transfusion-dependent thalassemia patients. Study Design: This study was a cross sectional study, conducted at the Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, Sindh, Pakistan from October 2014 to January 2016. Subjects and Methods: Of 921 blood samples, A. baumannii strains were isolated from 100 blood samples...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29298246/improving-antibiotic-prescribing-for-children-with-urinary-tract-infection-in-emergency-and-urgent-care-settings
#19
Nicole M Poole, Matthew P Kronman, Lori Rutman, Scott J Weissman, Russell T Migita, Derya Caglar, Danielle M Zerr
OBJECTIVES: Children with urinary tract infection (UTI) are often diagnosed in emergency and urgent care settings and increasingly are unnecessarily treated with broad-spectrum antibiotics. This study evaluated the effect of a quality improvement intervention on empiric antibiotic prescribing for the treatment of uncomplicated UTI in children. METHODS: A local clinical pathway for uncomplicated UTI, introduced in June 2010, recommended empiric treatment with cephalexin, a narrow-spectrum (first-generation) cephalosporin antibiotic...
January 2, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29285017/comparative-proteomics-analysis-of-neisseria-gonorrhoeae-strains-in-response-to-extended-spectrum-cephalosporins
#20
Sunanta Nabu, Ratana Lawung, Patcharee Isarankura-Na-Ayudhya, Sittiruk Roytrakul, Supamas Dolprasit, Sineenart Sengyee, Chartchalerm Isarankura-Na-Ayudhya, Virapong Prachayasittikul
Neisseria gonorrhoeae strains displaying reduced susceptibility and resistance to extended-spectrum cephalosporins (ESCs) are major public health concerns. Although resistance mechanisms of ESCs have extensively been studied, the proteome-wide investigation on the biological response to the antibiotic stress is still limited. Herein, a proteomics approach based on two-dimensional gel electrophoresis and MALDI-TOF/TOF-MS analysis was applied to investigate the global protein expression under ESC stresses of ESC-susceptible and ESC-reduced susceptible N...
2017: EXCLI Journal
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