keyword
https://read.qxmd.com/read/38508350/the-piezo1-mir-155-5p-gdf6-smad2-3-signaling-axis-is-involved-in-inducing-the-occurrence-and-progression-of-osteoarthritis-under-excessive-mechanical-stress
#21
JOURNAL ARTICLE
Chaoren Qin, Yan Feng, Zhaowei Yin, Changjiang Wang, Rui Yin, Yang Li, Kai Chen, Tianqi Tao, Kaibin Zhang, Yiqiu Jiang, Jianchao Gui
OBJECTIVE: To elucidate the molecular mechanism of overloading-induced osteoarthritis (OA) and to find a novel therapeutic target. METHODS: We utilized human cartilage specimens, mouse chondrocytes, a destabilization of the medial meniscus (DMM) mouse model, and a mouse hindlimb weight-bearing model to validate the role of overloading on chondrocyte senescence and OA development. Then, we observed the effect of PIEZO1-miR-155-5p-GDF6-SMAD2/3 signaling axis on the preservation of joint metabolic homeostasis under overloading in vivo, in vitro and ex vivo by qPCR, Western blot, enzyme-linked immunosorbent assay (ELISA), immunohistochemistry, immunofluorescence, SA-β-gal staining, CCK8 assay, et al...
March 18, 2024: Cellular Signalling
https://read.qxmd.com/read/38508288/return-to-sport-after-ulnar-collateral-ligament-tears-treated-with-platelet-rich-plasma-injections-is-influenced-by-length-of-rehabilitation-and-leukocyte-content-of-injections-a-systematic-review
#22
REVIEW
Stephen P Fucaloro, Alex S Kang, Jack T Bragg, Laura Krivicich, Matthew J Salzler
PURPOSE: To analyze current literature assessing return to sport (RTS) outcomes following platelet rich plasma (PRP) injections for the non-operative treatment of ulnar collateral ligament (UCL) injuries. METHODS: A systematic review of PubMed, Embase, and Web of Science databases was conducted in June 2023 to identify studies assessing RTS following PRP injections for UCL injuries. Tear severity, leukocyte content of PRP, rehabilitation protocol, and RTS outcomes were collected...
March 18, 2024: Arthroscopy
https://read.qxmd.com/read/38506684/do-patients-accurately-recall-pain-levels-following-sacroiliac-joint-steroid-injection-a-cohort-study-of-recall-bias-in-patient-reported-outcomes
#23
JOURNAL ARTICLE
Davin C Gong, Aditya Muralidharan, Bilal B Butt, Ronald Wasserman, Joshua D Piche, Rakesh D Patel, Ilyas Aleem
BACKGROUND: Sacroiliac joint (SIJ) injections are crucial in the diagnostic toolkit for evaluating SIJ pathology. Recall bias is an important component in patient-reported outcomes that has not been well studied in SIJ injection. OBJECTIVE: The purpose of this study was to characterize the accuracy, direction, and magnitude of pain level recall bias following SIJ steroid injection and study the factors that affect patient recollection. STUDY DESIGN: Prospective cohort study...
March 2024: Pain Physician
https://read.qxmd.com/read/38505561/can-ethanol-ablation-achieve-durable-control-of-neck-nodal-recurrences-in-adults-with-stage-i-papillary-thyroid-cancer
#24
JOURNAL ARTICLE
Ian D Hay, Robert A Lee, Carl C Reading, J William Charboneau
OBJECTIVE: Results of ethanol ablation (EA) for controlling neck nodal metastases (NNM) in adult patients with papillary thyroid carcinoma (APTC) beyond 6 months have rarely been reported. We now describe outcome results in controlling 71 NNM in 40 node-positive stage I APTC patients followed for 66 to 269 months. METHODS: All 40 patients were managed with bilateral thyroidectomy and radioiodine therapy and followed with neck ultrasound (US) for >48 months after EA...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38502336/minimally-invasive-treatment-for-idiopathic-chondrolysis-of-the-hip-analysis-of-forty-one-cases
#25
JOURNAL ARTICLE
Sandeep Patwardhan, Sanika Rapole, Udit Vinayak, Ashok Shyam, Parag Kantilal Sancheti, Vineet Bangad
PURPOSE: Idiopathic chondrolysis of the hip is characterized by the loss of the articular cartilage of the hip joint with spectrum ranging from full recovery to fibrous ankylosis. Study assessed outcomes following intra-articular steroid injections, joint manipulation and traction immobilization. METHODS: Retrospective (2012-2021) review of 41 cases treated for idiopathic chondrolysis of hip, assessed pre-operatively and post-operatively (minimum 2-year follow-up) using Children's Hospital Oakland Hip Evaluation Score (CHOHES), visual analogue scale (VAS) and range of motion measurements...
March 19, 2024: International Orthopaedics
https://read.qxmd.com/read/38502232/dysregulated-fibrinolysis-and-plasmin-activation-promote-the-pathogenesis-of-osteoarthritis
#26
JOURNAL ARTICLE
Qian Wang, Guoqiang Shao, Xiaoyi Zhao, Heidi H Wong, Kate Chin, Mackenzie Zhao, Audrey Bai, Michelle S Bloom, Zelda Z Love, Constance R Chu, Zhen Cheng, William H Robinson
Joint injury is associated with risk for development of osteoarthritis (OA). Increasing evidence suggests that activation of fibrinolysis is involved in OA pathogenesis. However, the role of the fibrinolytic pathway is not well understood. Here we showed that the fibrinolytic pathway, which includes plasminogen/plasmin, tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA) and the uPA receptor (uPAR), were dysregulated in human OA joints. Pharmacological inhibition of plasmin attenuated OA progression in a destabilization of the medial meniscus (DMM) mouse model, while genetic deficiency of plasmin activator inhibitor (PAI-1), or injection of plasmin, exacerbated OA...
March 19, 2024: JCI Insight
https://read.qxmd.com/read/38500930/efficacy-of-injectable-platelet-rich-fibrin-i-prf-in-managing-temporomandibular-joint-pain-a-prospective-clinical-study
#27
JOURNAL ARTICLE
Nithin Kumar, Mariea Francis, Sai Sindhu Vk, Varun Ramachandra, P Vijay Anilkumar, Mohammad Fahad Khan
BACKGROUND: Temporomandibular joint (TMJ) pain is a common condition that can significantly impact an individual's quality of life. Current treatment options often fall short of providing long-lasting relief. So, this prospective clinical study aimed to investigate the efficacy of injectable platelet-rich fibrin (I-PRF) in mitigating TMJ pain. METHODS: A total of 68 participants, aged 18-60 years, clinically diagnosed with TMJ pain, were recruited from dental clinics and specialist referrals...
February 2024: Curēus
https://read.qxmd.com/read/38500321/guasha-improves-knee-osteoarthritis-by-inhibiting-chondrocyte-apoptosis-and-regulating-expression-of-autophagy-related-genes-and-proteins-in-rats
#28
JOURNAL ARTICLE
Xue-Hua Yan, Hao Zhu, Shuai Chen, Gai-Yue Zhang, Hao-Bin Zhang, Jin-Sheng Yang, Ying-Ying Wang
OBJECTIVES: To observe the effect of Guasha on inflammation factors, apoptosis and autophagy in the cartilage tissue of knee joint in rats with knee osteoarthritis (KOA), so as to explore its mechanisms underlying improvement of KOA. METHODS: A total of 51 male SD rats were randomized into three groups:blank control, KOA model and Guasha ( n = 17 in each group) . The rats in the blank control group received intra-articular injection of 0.9% NaCl solution in the right knee joint...
March 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/38499191/prophylactic-treatment-of-children-with-hemophilia-in-sweden
#29
JOURNAL ARTICLE
Rolf Ljung
Hemophilia A/B are caused by deficiency or lack of coagulation factors VIII (FVIII) or factor IX (FIX), respectively, in plasma. A person with hemophilia develops bleeding in the joints and muscles at an early age, which, if left untreated, leads to early arthropathy. Preventive treatment can be achieved by regular (prophylactic) administration of FVIII/FIX. In 1958, this was implemented on a small scale in Sweden with FVIII in patients with severe hemophilia A, and in those with hemophilia B in 1972 when FIX became available...
March 18, 2024: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/38498142/long-term-efficacy-following-intra-articular-injection-of-carboxymethyl-chitosan-a-new-product-class-for-knee-osteoarthritis-results-from-an-observational-study-in-germany
#30
JOURNAL ARTICLE
Nils A Lynen, Christoph Eichhorn, Nicolas Portelange, Mickaël Chausson, Wim Weyenberg
INTRODUCTION: Evaluate the real-world efficacy of a single intra-articular injection of carboxymethyl-chitosan (CM-chitosan), a new product class for knee osteoarthritis (OA). METHODS: This post-marketing study included adult patients with knee OA, who received a single injection of 60 mg CM-chitosan (currently marketed as KioMedinevs one) according to the instructions for use. Follow-up was performed at weeks 1, 12, 24, and 36. Efficacy was evaluated using a Visual Analog Scale (VAS) score for pain, the Knee injury and Osteoarthritis Outcome Score (KOOS), Patient's Global Assessment (PGA), and overall patient satisfaction...
March 18, 2024: Rheumatology and Therapy
https://read.qxmd.com/read/38493143/low-intensity-pulsed-ultrasound-delays-the-progression-of-osteoarthritis-by-regulating-the-yap-ripk1-nf-%C3%AE%C2%BAb-axis-and-influencing-autophagy
#31
JOURNAL ARTICLE
Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo, Tao Xu
BACKGROUND: Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even disability. The risk factors for OA include genetics, gender, trauma, obesity, and age. Unfortunately, due to limited understanding of its pathological mechanism, there are currently no effective drugs or treatments to suspend the progression of osteoarthritis. In recent years, some studies found that low-intensity pulsed ultrasound (LIPUS) may have a positive effect on osteoarthritis...
March 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38488127/zeolitic-imidazolate-framework-90-loaded-with-methylprednisolone-sodium-succinate-effectively-reduces-hypertrophic-scar-in-vivo
#32
JOURNAL ARTICLE
Xiaoxiang Xu, Jun Liu, Zixuan Xiao, Shuang Li, Ya Zhang, Peng Song, Kun Lin, Lei Zhang, Haoquan Zheng, Yuye Zhou, Xiong Chen
Hypertrophic scar (HS) is characterized by an abnormal fibroblast-myofibroblast transformation; non-apoptosis of fibroblasts; and redundant expression of TGF-β1, VEGF, α-SMA, and collagen I/III. An HS affects patients' physical and psychological quality of life, leading to joint dysfunction and skin cancer. However, there is currently no satisfactory drug to treat this disorder. In this study, we constructed methylprednisolone sodium succinate (MPSS) encapsulated ZIF-90 (MPSS@ZIF-90) for the effective treatment of an HS...
March 15, 2024: Nanoscale
https://read.qxmd.com/read/38486871/case-report-portable-handheld-ultrasound-facilitates-intra-articular-injections-in-articular-foot-pathologies
#33
Samir Ghandour, Atta Taseh, Walter Sussman, Daniel Guss, Soheil Ashkani-Esfahani, Ashim Gupta, Gregory Waryasz
BACKGROUND: Intra-articular injections are commonly used to manage joint pathologies, including osteoarthritis. While conventional ultrasound (US) guidance has generally improved intra-articular injection accuracy, forefoot and midfoot joint interventions are still often performed without imaging guidance. This pilot study aims to evaluate the efficacy of office-based, portable ultrasound (P-US) guided intra-articular injections for forefoot and midfoot joint pain caused by various degenerative pathologies...
2024: Front Pain Res (Lausanne)
https://read.qxmd.com/read/38486285/long-term-follow-up-of-109-children-with-juvenile-idiopathic-oligoarthritis-after-first-intra-articular-corticosteroid-injection
#34
JOURNAL ARTICLE
Mojca Zajc Avramovič, Nataša Toplak, Gašper Markelj, Nina Emeršič, Tadej Avčin
BACKGROUND: To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as oligoarthritis, who received IAC as the first treatment for their disease. METHODS: We conducted retrospective study at the University Children's Hospital Ljubljana, Slovenia, from January 2015 to May 2023 in children with JIA, clinically presenting as oligoarthritis receiving intra-articular corticosteroid injection (IAC) as the initial treatment...
March 14, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38484831/ph-responsive-size-adjustable-liposomes-induce-apoptosis-of-fibroblasts-and-macrophages-for-rheumatoid-arthritis-treatment
#35
JOURNAL ARTICLE
Xiu Zheng, Hong Yang, Zongquan Zhang, Xiaoya Liang, Yan Liu, Chenglong Wang, Xi Yang, Jun Tang, Jingying Mao, Yu Nie, Xiangyu Zhou, Chunhong Li
In rheumatoid arthritis (RA), macrophages infiltrate joints, while fibroblast-like synovial cells proliferate abnormally, forming a barrier against drug delivery, which hinders effective drug delivery to joint focus. Here we firstly designed a pH-responsive size-adjustable nanoparticle, composed by methotrexate (MTX)-human serum albumin (HSA) complex coating with pH-responsive liposome (Lipo/MTX-HSA) for delivering drugs specifically to inflamed joints in acidic environments. We showed in vitro that the nanoparticles can induce mitochondrial dysfunction, promote apoptosis of fibroblast-like synoviocytes and macrophages, further reduce the secretion of inflammatory factors (TNF-α, IL-1β, MMP-9), and regulate the inflammatory microenvironment...
March 12, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38483312/reproducible-synthesis-of-biocompatible-albumin-nanoparticles-designed-for-intra-articular-administration-of-celecoxib-to-treat-osteoarthritis
#36
JOURNAL ARTICLE
Rumi Khandelia, Tom Hodgkinson, Daniel Crean, Dermot F Brougham, Dimitri Scholz, Hossam Ibrahim, Susan J Quinn, Brian J Rodriguez, Oran D Kennedy, John M O'Byrne, David J Brayden
Osteoarthritis (OA) is the most common form of arthritis, with intra-articular (IA) delivery of therapeutics being the current best option to treat pain and inflammation. However, IA delivery is challenging due to the rapid clearance of therapeutics from the joint and the need for repeated injections. Thus, there is a need for long-acting delivery systems that increase the drug retention time in joints with the capacity to penetrate OA cartilage. As pharmaceutical utility also demands that this is achieved using biocompatible materials that provide colloidal stability, our aim was to develop a nanoparticle (NP) delivery system loaded with the COX-2 inhibitor celecoxib that can meet these criteria...
March 14, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38482044/sustained-morphine-exposure-alters-spinal-nmda-receptor-and-astrocyte-expression-and-exacerbates-chronic-pain-behavior-in-female-rats
#37
JOURNAL ARTICLE
Sara V Gonçalves, Stephen G Woodhams, Li Li, Gareth J Hathway, Victoria Chapman
INTRODUCTION: Sustained opioid use has long-term negative impacts on future pain experience, particularly in women. This study aimed to investigate the underlying spinal neurobiology of this clinical observation in an experimental model of joint pain. OBJECTIVES: In this study, we tested the hypothesis that sustained opioid treatment exacerbates chronic pain responses and alters spinal cord dorsal horn astrogliosis and the expression of GluN2B-containing N-methyl-d-aspartate receptors in female rats...
April 2024: Pain Reports
https://read.qxmd.com/read/38479156/iron-overload-promotes-hemochromatosis-associated-osteoarthritis-via-the-mtorc1-p70s6k-4e-bp1-pathway
#38
JOURNAL ARTICLE
Zhiyuan Fang, Chengwei Wang, Jiang Zhu, Yangyang Gou
BACKGROUNDS: Joint iron overload in hemochromatosis induces M1 polarization in synovial macrophages, releasing pro-inflammatory factors and leading to osteoarthritis development. However, the mechanism by which iron overload regulates M1 polarization remains unclear. This study aims to elucidate the mechanism by which synovial iron overload promotes macrophage M1 polarization. METHODS: In vitro, RAW264.7 macrophages were treated with iron and divided into five groups based on the concentration of the iron chelator, desferrioxamine (DFO): Ctrl, Fe, DFO1, DFO2, and DFO3...
March 12, 2024: International Immunopharmacology
https://read.qxmd.com/read/38476786/effect-of-short-agonist-stop-sas-protocol-in-a-patient-having-an-allergic-reaction-from-conventional-ovarian-stimulating-hormone
#39
Al Hera Ansari, Akash More, Shilpa Dutta, Namrata Choudhary, Jarul Shrivastava, Rokaiya Shaikh
The case study examined a 32-year-old female and her 35-year-old partner who had experienced infertility attributed to the wife's irregular ovulation. Despite the male partner demonstrating normal reproductive parameters, he had a medical history involving hypertension. The woman also had a history of hypertension and chikungunya, which was accompanied by fever and joint pain in 2019. Due to the woman's allergic reaction to traditional ovulation stimulatory medications, the approach to assisted reproductive technologies (ART) had shifted towards employing the short agonist stop (SAS) regimen...
February 2024: Curēus
https://read.qxmd.com/read/38475923/clinical-safety-and-feasibility-of-a-novel-implantable-neuroimmune-modulation-device-for-the-treatment-of-rheumatoid-arthritis-initial-results-from-the-randomized-double-blind-sham-controlled-reset-ra-study
#40
JOURNAL ARTICLE
Daniel Peterson, Mark Van Poppel, Warren Boling, Perry Santos, Jason Schwalb, Howard Eisenberg, Ashesh Mehta, Heather Spader, James Botros, Frank D Vrionis, Andrew Ko, P David Adelson, Bradley Lega, Peter Konrad, Guillermo Calle, Fernando L Vale, Richard Bucholz, R Mark Richardson
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes persistent synovitis, bone damage, and progressive joint destruction. Neuroimmune modulation through electrical stimulation of the vagus nerve activates the inflammatory reflex and has been shown to inhibit the production and release of inflammatory cytokines and decrease clinical signs and symptoms in RA. The RESET-RA study was designed to determine the safety and efficacy of an active implantable device for treating RA...
March 13, 2024: Bioelectronic Medicine
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