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https://www.readbyqxmd.com/read/28822720/juvenile-idiopathic-arthritis-practice-patterns-among-oral-and-maxillofacial-surgeons
#1
Brian E Kinard, Shelly Abramowicz
PURPOSE: The purpose of this investigation is to assess the current clinical practices by oral and maxillofacial surgeons (OMSs) in the United States regarding diagnosis and treatment of temporomandibular joint (TMJ) involvement in children with juvenile idiopathic arthritis (JIA). MATERIALS AND METHODS: We implemented a cross-sectional survey of academic OMSs in the United States via an electronic survey. The survey included respondent demographic data, patient volumes, diagnostic methods, and management practices for children with JIA and TMJ involvement...
July 25, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28818450/development-and-delivery-of-a-physiotherapist-led-exercise-intervention-in-a-randomised-controlled-trial-for-subacromial-impingement-syndrome-the-support-trial
#2
Kay Stevenson, Sue Jackson, Julie Shufflebotham, Edward Roddy, Nadine E Foster
PURPOSE: This paper describes the development, content and delivery of a physiotherapist- led individualised, supervised and progressed exercise programme for use in a factorial randomised controlled trial testing treatments for subacromial impingement syndrome. METHODS: To develop the intervention, a survey of community physiotherapists and national guidelines provided the basis for a consensus workshop through which a protocol was developed for the SUPPORT trial physiotherapist-led exercise programme (SUPPORT: SUbacromial impingement syndrome and Pain: a randomised controlled trial Of exeRcise and injection)...
March 24, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28815179/interleukin-17-can-induce-osteoarthritis-in-rabbit-knee-joints-similar-to-hulth-s-method
#3
Zili Wang, Chenhuang Zheng, Yunbin Zhong, Jinshen He, Xu Cao, Hansong Xia, Hongliang Ba, Pei Li, Song Wu, Cheng Peng
Interleukin-17 (IL-17) is closely related to osteoarthritis (OA), but animal studies that employ IL-17 to induce OA are currently lacking. Therefore, this study evaluated the effect of IL-17 in the rabbit knee joint. The right knees served as the control group. The left knees were divided randomly into 4 groups: a Hulth group and 3 IL-17 groups (1-ng, 10-ng, and 50-ng groups). OA was induced in the Hulth group using Hulth's method. The IL-17 groups were injected with 1, 10, or 50 ng of IL-17 as indicated. Specimens were collected at 72 h, 1 week, 3 weeks, 6 weeks, and 12 weeks after surgery or the last injection...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28814056/design-of-a-lightweight-tethered-torque-controlled-knee-exoskeleton
#4
Kirby Ann Witte, Andreas M Fatschel, Steven H Collins
Lower-limb exoskeletons show promise for improving gait rehabilitation for those with chronic gait abnormalities due to injury, stroke or other illness. We designed and built a tethered knee exoskeleton with a strong lightweight frame and comfortable, four-point contact with the leg. The device is structurally compliant in select directions, instrumented to measure joint angle and applied torque, and is lightweight (0.76 kg). The exoskeleton is actuated by two off-board motors. Closed loop torque control is achieved using classical proportional feedback control with damping injection in conjunction with iterative learning...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28814000/preliminary-study-of-a-robotic-foot-ankle-prosthesis-with-active-alignment
#5
Andrew K LaPre, Ryan D Wedge, Brian R Umberger, Frank C Sup
Robotic prosthetic foot-ankle prostheses typically aim to replace the lost joint with revolute joints aimed at replicating normal joint biomechanics. In this paper, a previously developed robotic ankle prosthesis with active alignment is evaluated. It uses a four-bar mechanism to inject positive power into the gait cycle while altering the kinematics of the ankle joint and pylon segment to reduce loading on the residual limb. In a single-subject biomechanics analysis, there was a 10% reduction in peak limb pressures and evidence of greater gait symmetry in ground reaction forces when active alignment was implemented compared to walking with the daily use prosthesis...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28810691/improvement-of-implantation-potential-in-mouse-blastocysts-derived-from-ivf-by-combined-treatment-with-prolactin-epidermal-growth-factor-and-4-hydroxyestradiol
#6
Miki Takeuchi, Misato Seki, Etsuko Furukawa, Akihito Takahashi, Kyosuke Saito, Mitsuru Kobayashi, Kenji Ezoe, Emiko Fukui, Midori Yoshizawa, Hiromichi Matsumoto
STUDY QUESTION: Can supplementation of medium with prolactin (PRL), epidermal growth factor (EGF) and 4-hydroxyestradiol (4-OH-E2) prior to embryo transfer improve implantation potential in mouse blastocysts derived from IVF? SUMMARY ANSWER: Combined treatment with PRL, EGF and 4-OH-E2 improves mouse blastocyst implantation rates, while alone, each factor is ineffective. WHAT IS KNOWN ALREADY: Blastocyst dormancy during delayed implantation caused by ovariectomy is maintained by continued progesterone treatment in mice, and estrogen injection rapidly activates blastocysts to implantation-induced status in vivo...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28808696/psychological-stress-alters-extracellular-matrix-metabolism-in-mandibular-condylar-cartilage
#7
Qiang Li, Fei Huang, Jia Liu, Yin Hua Zhao, Min Zhang, Yong Jin Chen
OBJECTIVE: To explore the effect of long-term stress on the temporomandibular joint (TMJ) condyle and its possible underlying mechanism. METHODS: A 12-week, chronic unpredictable mild stress (CUMS) model was used to induce long-term psychological stress in rats. Rats were randomly divided into control group (CONT), chronic unpredictable mild stress group (CUMS) and chronic unpredictable mild stress with fluoxetine treatment group (CUMS + DT) (n = 30 per group). A 5 mg/kg dose of fluoxetine was intraperitoneally injected daily 0...
2017: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/28807034/exosomes-from-embryonic-mesenchymal-stem-cells-alleviate-osteoarthritis-through-balancing-synthesis-and-degradation-of-cartilage-extracellular-matrix
#8
Yafei Wang, Dongsheng Yu, Zhiming Liu, Fang Zhou, Jun Dai, Bingbing Wu, Jing Zhou, Boon Chin Heng, Xiao Hui Zou, Hongwei Ouyang, Hua Liu
BACKGROUND: Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have been implicated in many diseases and are known to participate in many physiological processes. Here, we investigate the therapeutic potential of exosomes from human embryonic stem cell-induced mesenchymal stem cells (ESC-MSCs) in alleviating osteoarthritis (OA). METHODS: Exosomes were harvested from conditioned culture media of ESC-MSCs by a sequential centrifugation process...
August 14, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28806826/-treatment-of-dupuytren-s-disease-with-collagenase-injections-in-germany-efficacy-and-adverse-effects-in-110-treated-joints
#9
Adrian Pototschnig, Elias Volkmer, Riccardo E Giunta
Background Since 2011, a new minimally-invasive treatment for Dupuytren's disease has been available in the form of injectable collagenase (Xiapex®, Pfizer). Purpose Our aim is to report about the results and adverse effects of injectable collagenase for the treatment of Dupuytren's disease in Germany. Patients and Methods We treated 78 patients (61 male, 17 female) with 87 injections in 87 digits (little finger n = 40, ring finger n = 37, middle finger n = 8 and index n = 2). We documented the range of motion before treatment, after 6 weeks and after 6 months...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28803211/melatonin-protects-chondrocytes-from-impairment-induced-by-glucocorticoids-via-nad-dependent-sirt1
#10
Wei Yang, Xiaomin Kang, Na Qin, Feng Li, Xinxin Jin, Zhengmin Ma, Zhuang Qian, Shufang Wu
Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in osteoarthritis patients, which is occasionally accompanied with the serious side effects of glucocorticoids in collagen-producing tissue. Melatonin is the major hormone released from the pineal gland and its beneficial effects on cartilage has been suggested. In the present study, we investigated the protective role of melatonin on matrix degeneration in chondrocytes induced by dexamethasone (Dex). The chondrocytes isolated from mice knee joint were treated with Dex, melatonin, EX527 and siRNA targeted for SIRT6, respectively...
August 10, 2017: Steroids
https://www.readbyqxmd.com/read/28800776/revisiting-clinico-epidemiological-pattern-of-human-rickettsial-infections-in-the-central-region-of-sri-lanka-a-hospital-based-descriptive-study
#11
Kosala Gayan Weerakoon, Senanayake A M Kularatne, Jayanthe Rajapakse, Sanjaya Adikari, Kanchana Udayawarna
BACKGROUND: This study revisits the clinico-epidemiology and serological patterns of rickettsioses in the central region of Sri Lanka and highlights the need of advanced diagnostics for precise identification of species responsible for rickettsioses. METHODS: The patients treated for rickettsioses between November 2009 and October 2011 were recruited for the study from Teaching Hospital, Peradeniya. Clinical characteristics and serology results were used for diagnosis...
August 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28797833/percutaneous-rupture-of-zygapophyseal-joint-synovial-cysts-a-prospective-assessment-of-nonsurgical-management
#12
Gregory E Lutz, Michael R Nicoletti, George E Cyril, Julian R Harrison, Christopher Lutz, Jennifer L Solomon, Paul M Cooke, James F Wyss, Richard J Herzog, Peter J Moley
BACKGROUND: Although lumbar zygapophyseal joint synovial cysts are fairly well recognized, they are an uncommon cause of lumbosacral radicular pain. Non-operative treatments include percutaneous aspiration of the cysts under computed tomography or fluoroscopic guidance with a subsequent corticosteroid injection. However, there are mixed results in terms of long-term outcomes and cyst reoccurrence. This study prospectively evaluates percutaneous ruptures of zygapophyseal joint (Z-joint) synovial cysts for the treatment of lumbosacral radicular pain...
August 7, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28797764/inflammatory-pain-assessment-in-the-arthritis-of-the-temporomandibular-joint-in-rats-a-comparison-between-two-phlogistic-agents
#13
Joana Cláudia Bezerra de Araújo, Delane Viana Gondim, André Luiz Cunha Cavalcante, Mario Roberto Pontes Lisboa, Gerly Anne de Castro Brito, Mariana Lima Vale
Temporomandibular joint (TMJ) disorders are a group of conditions that result in TMJ pain, which frequently limits basic daily activities. Experimental models that allow the study of the mechanisms underlying these inflammatory and pain conditions are of great clinical relevance. The aim of this study was to evaluate nociception, inflammation and participation of the macrophage/microglia cells in the arthritis of the TMJ induced by two phlogistic agents. 84 rats were divided into 2 groups: Zy, which received zymosan intra-articularly, or Cg, which received carrageenan intra-articularly...
August 8, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28794657/repeated-administration-of-mazindol-reduces-spontaneous-pain-related-behaviors-without-modifying-bone-density-and-microarchitecture-in-a-mouse-model-of-complete-freund-s-adjuvant-induced-knee-arthritis
#14
L E Robledo-González, A Martínez-Martínez, V M Vargas-Muñoz, R I Acosta-González, R Plancarte-Sánchez, M Anaya-Reyes, C Fernández Del Valle-Laisequilla, J G Reyes-García, J M Jiménez-Andrade
BACKGROUND: The role of dopaminergic system in the development of rheumatoid arthritis-related pain, a major symptom in this disease, has not been explored. Therefore, the anti-nociceptive effect of mazindol, a dopamine uptake inhibitor, was evaluated in a model of complete Freund's adjuvant (CFA)-induced arthritis. Furthermore, as studies have shown that the dopaminergic system regulates bone metabolism, the effect of mazindol on bone mass and microarchitecture was determined. METHODS: Adult ICR male mice received intra-articular injections of either CFA or saline into the right knee joint every week...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28791820/evaluation-of-articular-disc-loading-in-the-temporomandibular-joints-after-prosthetic-and-pharmacological-treatment-in-model-studies
#15
Małgorzata E Pihut, Jerzy Margielewicz, Edward Kijak, Grażyna Wiśniewska
BACKGROUND: Temporomandibular joint dysfunction is often related to excessive load in the stomatognathic system. OBJECTIVES: The objective of the model tests, using numeric calculations, was to assess the articular disc loads in the temporomandibular joints after prosthetic and pharmacological treatment of functional disorders of the masticatory organ. MATERIAL AND METHODS: The study involved 10 patients, aged 21-48 years, of both sexes, randomly selected from a group of 120 patients treated with relaxation occlusal splints (60 patients, group I) and intramuscular injection of botulinum toxin type A (60 patients, group II), suffering from temporomandibular joint dysfunction with the dominant muscle component...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28790870/repository-corticotropin-injection-as-adjunctive-therapy-in-patients-with-rheumatoid-arthritis-who-have-failed-previous-therapies-with-at-least-three-different-modes-of-action
#16
Theresa Gillis, Megan Crane, Carly Hinkle, Nathan Wei
OBJECTIVE: Many types of treatment are available for patients with rheumatoid arthritis (RA), however, some patients fail to achieve remission. This report aims to determine the safety and efficacy of using repository corticotropin injection (RCI) as an adjunctive therapy in patients with RA refractory to at least three therapeutics with different mechanisms of action. METHOD: In this open-label, interventional, single-group study, patients received 80 U RCI twice weekly via subcutaneous injection over 12 weeks...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28783888/attenuation-of-collagen-induced-arthritis-by-hyperbaric-oxygen-therapy-through-altering-immune-balance-in-favor-of-regulatory-t-cells
#17
Byung-In Moon, Hyung-Ran Kim, Eun-Jeong Choi, Jeong-Hae Kie, Ju-Young Seoh
Hyperbaric oxygen (HBO₂) therapy is currently used for the treatment of chronic wounds, radiation-induced soft tissue necrosis, several oxygen-deficiency conditions and decompression sickness. In addition to the current indications, much empirical and experimental data suggest that HBO₂ therapy may benefit autoimmune diseases by suppressing immunity, but the underlying mechanism is not well understood. Therefore, in the present study, we investigated whether HBO₂ prevents the development of collagen-induced arthritis (CIA) in association with alteration of the immune balance between pro-inflammatory Th17 and anti-inflammatory regulatory T cells (Tregs)...
July 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28782280/orthopaedic-wear-particle-induced-bone-loss-and-exogenous-macrophage-infiltration-is-mitigated-by-local-infusion-of-nf-%C3%AE%C2%BAb-decoy-oligodeoxynucleotide
#18
Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, Luis A Córdova, Florence Loi, Emmanuel Gibon, Laura Lu, Karthik Nathan, Eemeli Jämsen, Zhenyu Yao, Stuart B Goodman
Excessive production of wear particles from total joint replacements (TJRs) induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are critically regulated by the transcription factor NF-κB. We previously demonstrated that inhibition of NF-κB signaling by using the decoy oligodeoxynucleotide (ODN) mitigates polyethylene wear particle-induced bone loss using in vitro and in vivo models. However, the mechanisms of NF-κB decoy ODN action, and in particular its impact on systemic macrophage recruitment, remain unknown...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28781725/the-impact-of-synovial-nf-%C3%AE%C2%BAb-activation-on-apoptosis-pattern-change-during-adjuvant-induced-inflammation
#19
Sahar Golabi, Jalal Zaringhalam, Homa Manaheji
INTRODUCTION: Apoptosis dysregulation plays a substantial role in the pathophysiology of chronic inflammation and its related symptoms such as edema. Regulation of NF-κB activation is involved in apoptosis pattern change. The current study aimed at verifying the effects of local inflammation on edema and changes in apoptotic markers, and investigating the possible role of NF-κB in apoptosis pattern change during different stages of complete Freund's adjuvant (CFA)-induced knee arthritis in rats...
May 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28779847/efficacy-of-intralesional-sodium-thiosulfate-injections-for-disabling-tumoral-calcinosis-two-cases
#20
J Goossens, M Courbebaisse, E Caudron, C Bahans, V Vacquerie, J Melchior, P Vergne Salle, C Moesch, M Daudon, V Frocht, P Richette, Hang-Korng Ea, V Guigonis
INTRODUCTION: Tumoral calcinosis (TC) is a difficult-to-treat complication that can occur during several diseases such as dermatomyositis or genetic hyperphosphatemia. It is a painful and disabling condition that can lead to local complications including joint mobility reduction, cutaneous ulceration and superinfection. For the largest lesions, the treatment relies essentially on surgery. Intravenous sodium thiosulfate (STS) is efficient to treat calciphylaxis in patients undergoing hemodialysis...
June 17, 2017: Seminars in Arthritis and Rheumatism
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