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https://www.readbyqxmd.com/read/29773663/factors-associated-with-condom-use-and-hiv-testing-among-young-men-who-have-sex-with-men-a-cross-sectional-survey-in-a-random-online-sample-in-sweden
#1
Klara Johansson, Kristina Ingemarsdotter Persson, Charlotte Deogan, Ziad El-Khatib
OBJECTIVES: The objectives are to analyse social determinants of sexual health behaviour (condom use and HIV testing) among young, internet-active, cis men who have sex with men (MSM) in a high-income country. The aspects of sexual health behaviour analysed here are condomless anal intercourse with one or more new or casual partner(s), condomless anal intercourse during the most recent sex with a man and HIV testing. METHODS: A randomised sample of men active on Sweden's main online community for Lesbian, Gay, Bisexual and Trans people responded to an online survey (response rate 19%)...
May 17, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29767952/laser-cleavable-probes-based-cell-surface-engineering-for-in-situ-sialoglycoconjugates-profiling-by-ldi-mass-spectrometry
#2
Jie Sun, Huihui Liu, Lingpeng Zhan, Caiqiao Xiong, Xi Huang, Jinjuan Xue, Zongxiu Nie
Cell-surface sialoglycoconjugates (sialoglycoproteins & sialoglycolipids) play important roles in cell-cell interactions and related tumor metastasis process. Although there have been some analytical methods to evaluate the sialoglycoconjugates, an effective method providing both qualitative and quantitative information is still deficient. Here we establish an extraction-free, sensitive and high-throughput platform to realize in-situ detection of the cell-surface sialoglycoconjugates on various cell lines, e...
May 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29766779/technetium-99m-based-radiopharmaceuticals-in-sentinel-lymph-node-biopsy-gynecologic-oncology-perspective
#3
Kamil Zalewski, Malgorzata Benke, Bartlomiej Mirocha, Jakub Radziszewski, Magdalena Chechlinska, Magdalena Kowalewska
Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become part of surgical treatment. However, not all patients with LN involvement benefit from extensive lymphadenectomy in terms of prolonged survival. Moreover, overtreatment of patients with localized disease carries unnecessary risk of complications...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29765480/effect-of-spike-timing-dependent-plasticity-on-stochastic-burst-synchronization-in-a-scale-free-neuronal-network
#4
Sang-Yoon Kim, Woochang Lim
We consider an excitatory population of subthreshold Izhikevich neurons which cannot fire spontaneously without noise. As the coupling strength passes a threshold, individual neurons exhibit noise-induced burstings. This neuronal population has adaptive dynamic synaptic strengths governed by the spike-timing-dependent plasticity (STDP). However, STDP was not considered in previous works on stochastic burst synchronization (SBS) between noise-induced burstings of sub-threshold neurons. Here, we study the effect of additive STDP on SBS by varying the noise intensity D in the Barabási-Albert scale-free network (SFN)...
June 2018: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29765348/numerical-affordance-influences-action-execution-a-kinematic-study-of-finger-movement
#5
Rosa Rugani, Sonia Betti, Luisa Sartori
Humans represent symbolic numbers as oriented from left to right: the mental number line (MNL). Up to now, scientific studies have mainly investigated the MNL by means of response times. However, the existing knowledge on the MNL can be advantaged by studies on motor patterns while responding to a number. Cognitive representations, in fact, cannot be fully understood without considering their impact on actions. Here we investigated whether a motor response can be influenced by number processing. Participants seated in front of a little soccer goal...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29765297/group-analysis-in-fieldtrip-of-time-frequency-responses-a-pipeline-for-reproducibility-at-every-step-of-processing-going-from-individual-sensor-space-representations-to-an-across-group-source-space-representation
#6
Lau M Andersen
An important aim of an analysis pipeline for magnetoencephalographic (MEG) data is that it allows for the researcher spending maximal effort on making the statistical comparisons that will answer his or her questions. The example question being answered here is whether the so-called beta rebound differs between novel and repeated stimulations. Two analyses are presented: going from individual sensor space representations to, respectively, an across-group sensor space representation and an across-group source space representation...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29763974/engineering-a-human-skin-equivalent-to-study-dermis-remodeling-and-epidermis-senescence-in-vitro-after-uva-exposure
#7
Costantino Casale, Giorgia Imparato, Francesco Urciuolo, Francesca Rescigno, Sara Scamardella, Maria Escolino, Paolo A Netti
UVA exposure strongly affects the ageing of human skin by modifying both epidermis and dermis and their cross talk as well. The possibility to get a deep understanding in vitro of such crucial mechanism would have a huge impact in the development of anti-ageing compounds. Here we present a full thickness model of human skin equivalent formed by a millimeter-sized dermis completely composed of fibroblasts embedded in their own extra-cellular matrix (ECM). We show that such endogenous nature of the dermis compartment allows the replication of the complexity of the mutual interactions occurring between cellular and extracellular components of the skin under UVA exposure: (i) oxidative stress formation in the whole tissue (dermis and epidermis); (ii) senescence of germinative layer of epidermal tissue in terms of p63, ki67 and activated caspase-3 regulation; (iii) modification of the collagenous network architecture in the dermis compartment...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29756830/inertial-movements-of-the-iris-as-the-origin-of-postsaccadic-oscillations
#8
S Bouzat, M L Freije, A L Frapiccini, G Gasaneo
Recent studies on the human eye indicate that the pupil moves inside the eyeball due to deformations of the iris. Here we show that this phenomenon can be originated by inertial forces undergone by the iris during the rotation of the eyeball. Moreover, these forces affect the iris in such a way that the pupil behaves effectively as a massive particle. To show this, we develop a model based on the Newton equation on the noninertial reference frame of the eyeball. The model allows us to reproduce and interpret several important findings of recent eye-tracking experiments on saccadic movements...
April 27, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29745841/fixation-probability-of-a-beneficial-mutation-conferring-decreased-generation-time-in-changing-environments
#9
Fangshu Cui, Bo Yuan
BACKGROUND: One central building block of population genetics is the fixation probability. It is a probabilistic understanding of the eventual fate of new mutations. Moreover, the fixation probability of new beneficial mutations plays an important effect on the adaptation of populations to environmental challenges. Great progress has been made in the study of the beneficial mutations that increases offspring number. However, the fixation probability of beneficial mutations with a shorter generation time under various genetic and ecological conditions has not been explored...
April 24, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29741048/-responses-of-the-natural-abundance-of-carbon-and-nitrogen-isotopes-of-quercus-mongolica-leaf-and-soil-to-elevated-co-2
#10
Jian Fei Sun, Wei Wei Dai, Tong Xin He, Bo Peng, Ping Jiang, Shi Jie Han, E Bai
The rising atmospheric CO2 concentration significantly changed soil nitrogen (N) cycling which is important for us to predict the carbon (C) sequestration potential of terrestrial ecosystems. The natural abundance of N isotope as an integrative indicator of ecosystem N cycling processes can effectively indicate the effect of elevated CO2 on soil N cycling processes. Here, we used an open top chamber experiment to examine the effects of elevated CO2 for ten years on the natural abundance of Quercus mongolica, soil and microbial biomass C and N isotopes in northeastern China...
July 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29737631/a-fluid-structure-interaction-fsi-based-numerical-investigation-of-peristalsis-in-an-obstructed-human-ureter
#11
Ahmed Tasnub Takaddus, Prashanta Gautam, Abhilash J Chandy
Urine moves from the kidney to the bladder through the ureter. A series of compression waves facilitates this transport. Due to the highly concentrated mineral deposits in urine, stones are formed in the kidney and travel down through the urinary tract. While passing, a larger stone can get stuck and cause severe damage to ureter wall. Also, stones in the ureter obstructing the urine flow can cause pain and backflow of urine which in turn might require surgical intervention. The current study develops a 2D axisymmetric numerical model in order to gain an understanding of the ureter obstruction and its effects on the flow, which are critical in assessing the different treatment options...
May 8, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29735625/how-did-we-get-here-heroin-and-fentanyl-trafficking-trends-a-law-enforcement-perspective
#12
Leslie Cooley Dismukes
Illicit heroin and fentanyl are infecting North Carolina's communities, and causing an increasing number of overdose deaths. These trends in drug trafficking and opioid misuse represent a dramatic shift, necessitating a new and coordinated law enforcement response. The North Carolina Attorney General's Office is committed to working toward increased enforcement, prevention, and treatment to address this epidemic.
May 2018: North Carolina Medical Journal
https://www.readbyqxmd.com/read/29734328/knowledge-attitudes-and-practices-kap-regarding-leptospirosis-among-residents-of-riverside-settlements-of-santa-fe-argentina
#13
Tamara Ricardo, Laura C Bergero, Esteban P Bulgarella, M Andrea Previtali
BACKGROUND: Leptospirosis is a global and re-emerging zoonotic disease caused by Leptospira spirochetes that are shed into the environment by infected animals. Humans can get infected via contact with animal hosts or contaminated environment. In Argentina, the highest annual incidences were reported in the province of Santa Fe, where epidemic outbreaks occurred during flooding events. This study examined the knowledge, attitudes and practices (KAP) regarding leptospirosis among residents of riverside slum settlements from Santa Fe after a major flood...
May 7, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29728314/nothing-personal-what-psychologists-get-wrong-about-identity
#14
Christina Starmans, Paul Bloom
What makes someone the same person over time? There is a growing body of research exploring how people ordinarily think about personal identity. We argue here that many of the experiments in this domain fail to properly distinguish similarity from personal identity, and therefore certain conclusions regarding commonsense intuitions about identity are not supported.
May 1, 2018: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29717216/scandium-doping-brings-speed-improvement-in-sb-2-te-alloy-for-phase-change-random-access-memory-application
#15
Xin Chen, Yonghui Zheng, Min Zhu, Kun Ren, Yong Wang, Tao Li, Guangyu Liu, Tianqi Guo, Lei Wu, Xianqiang Liu, Yan Cheng, Zhitang Song
Phase change random access memory (PCRAM) has gained much attention as a candidate for nonvolatile memory application. To develop PCRAM materials with better properties, especially to draw closer to dynamic random access memory (DRAM), the key challenge is to research new high-speed phase change materials. Here, Scandium (Sc) has been found it is helpful to get high-speed and good stability after doping in Sb2 Te alloy. Sc0.1 Sb2 Te based PCRAM cell can achieve reversible switching by applying even 6 ns voltage pulse experimentally...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29716324/note-a-simple-magnetic-field-design-for-dichroic-atomic-vapor-laser-lock
#16
Teng Xiao, Tong Wang, Bo Yan
The dichroic atomic vapor laser lock (DAVLL) is a very useful scheme for frequency stabilization. A bias field on the order of 100 G is required to get the error signal for frequency locking. Here we report a simple design for the bias field with the permanent magnetic balls. It is really simple and easy to adjust the magnitude. Since the DAVLL lock is not sensitive to the bias field, such a design is very suitable.
April 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29710716/brain-inflammation-connects-cognitive-and-non-cognitive-symptoms-in-alzheimer-s-disease
#17
M Clara Selles, Mauricio M Oliveira, Sergio T Ferreira
Alzheimer's disease (AD) is the main form of dementia in the elderly and affects greater than 47 million people worldwide. Care for AD patients poses very significant personal and economic demands on individuals and society, and the situation is expected to get even more dramatic in the coming decades unless effective treatments are found to halt the progression of the disease. Although AD is most commonly regarded as a disease of the memory, the entire brain is eventually affected by neuronal dysfunction or neurodegeneration, which brings about a host of other behavioral disturbances...
April 25, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29710618/an-integrated-cell-absorption-process-and-quantitative-pcr-assay-for-the-detection-of-the-infectious-virus-in-water
#18
Xuan Guo, Shang Wang, Chong-Lin Zhao, Jun-Wen Li, Jin-Yi Zhong
Here we developed an integrated cell absorption process and quantitative (reverse transcription) polymerase chain reaction (ICAP-q(RT)PCR) assay to detect infectious viruses, which based on the detection of the viral nucleic acid (RNA or DNA) in the early stage of viral attachment and entry towards cells. The results showed that the poliovirus or adenovirus whose concentration was as low as 0.2 TCID50 /mL could be detected by ICAP-q(RT)PCR after 4 h incubation. The ICAP-q(RT)PCR exhibited much higher sensitivity than the plaque assay...
April 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29708860/why-hate-the-good-guy-antisocial-punishment-of-high-cooperators-is-greater-when-people-compete-to-be-chosen
#19
Aleta Pleasant, Pat Barclay
When choosing social partners, people prefer good cooperators (all else being equal). Given this preference, people wishing to be chosen can either increase their own cooperation to become more desirable or suppress others' cooperation to make them less desirable. Previous research shows that very cooperative people sometimes get punished ("antisocial punishment") or criticized ("do-gooder derogation") in many cultures. Here, we used a public-goods game with punishment to test whether antisocial punishment is used as a means of competing to be chosen by suppressing others' cooperation...
April 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29708542/a-simple-flow-cytometry-based-assay-to-determine-in-vitro-antibody-dependent-enhancement-of-dengue-virus-using-zika-virus-convalescent-serum
#20
William G Valiant, Joseph J Mattapallil
Antibody dependent enhancement of infection has been shown to play a major role in Dengue viral pathogenesis. Traditional assays that measure the capacity of antibodies or serum to enhance infection in impermissible cell lines have relied on using viral output in the media followed by plaque assays to quantify infection. More recently, these assays have examined Dengue virus (DENV) infection in the cell lines using fluorescently labeled antibodies. Both these approaches have limitations that restrict the widespread use of these techniques...
April 10, 2018: Journal of Visualized Experiments: JoVE
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