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https://www.readbyqxmd.com/read/29227682/self-attractive-hartree-decomposition-partitioning-electron-density-into-smooth-localized-fragments
#1
Tianyu Zhu, Piotr de Silva, Troy Van Voorhis
Chemical bonding plays a central role in the description and understanding of chemistry. Many methods have been proposed to extract information about bonding from quantum chemical calculations, majority of them resorting to molecular orbitals as basic descriptors. Here, we present a method called Self-Attractive Hartree (SAH) decomposition, to unravel pairs of electrons directly from electron density, which unlike molecular orbitals, is a well defined observable that can be accessed experimentally. The key idea is to partition the density into a sum of one-electron fragments which simultaneously maximize self-repulsion and maintain regular shapes...
December 11, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29227444/the-association-between-local-economic-conditions-and-opioid-prescriptions-among-disabled-medicare-beneficiaries
#2
Chao Zhou, Ning Neil Yu, Jan L Losby
BACKGROUND: This paper concerns public health crises today-the problem of opioid prescription access and related abuse. Inspired by Case and Deaton's seminal work on increasing mortality among white Americans with lower education, this paper explores the relationship between opioid prescribing and local economic factors. OBJECTIVE: We examined the association between county-level socioeconomic factors (median household income, unemployment rate, Gini index) and opioid prescribing...
January 2018: Medical Care
https://www.readbyqxmd.com/read/29225446/use-of-internet-for-general-and-dental-health-along-acculturation-features-in-a-sample-of-mexican-americans
#3
Odette Aguirre, Rodrigo Mariño, Carlo Medina-Solís, Gerardo Maupomé
The objectives of this study were to explore self-reported Internet and electronic platforms used to search for and store medical and dental information among people of Mexican origin. A sample of adults self-identified as European American (250) and as Mexican American (255), residing in Central Indiana, answered a one-time survey that included technology use questions and measured acculturation via the Psychological-Behavioral Acculturation Scale. Overall use of information technologies was estimated through an Information and Communication Technology score...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29225185/reactive-oxygen-species-metabolism-and-plant-fungal-interactions
#4
REVIEW
Lauren M Segal, Richard A Wilson
Fungal interactions with plants can involve specific morphogenetic developments to access host cells, the suppression of plant defenses, and the establishment of a feeding lifestyle that nourishes the colonizer often-but not always-at the expense of the host. Reactive oxygen species (ROS) metabolism is central to the infection process, and the stage-specific production and/ or neutralization of ROS is critical to the success of the colonization process. ROS metabolism during infection is dynamic-sometimes seemingly contradictory-and involves endogenous and exogenous sources...
December 7, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29224434/percutaneous-intervention-to-correct-central-venous-port-catheter-malposition
#5
Yen-Hsiang Wang, Chieh-Shou Su, Keng-Hao Chang, Chi-Jen Went, Wen-Lieng Lee, Chih-Hung Lai
The use of central venous port access is increasing due to the requirements of multimodal intravenous therapy.1 However, catheter malposition in smaller veins can lead to vein thrombosis, phlebitis and pain. Herein, we report our experience with the use of percutaneous interventions to correct migrated port catheter malposition. Minimally invasive percutaneous interventional correction of malposition could be an alternative to extraction and re-implantation of malpositioned port catheters.
December 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29223505/pakistan-genetic-mutation-database-pgmd-a-centralized-pakistani-mutome-data-source
#6
Iqbal Qasim, Bilal Ahmad, Muzammil Ahmad Khan, Niamatullah Khan, Noor Muhammad, Sulman Basit, Saadullah Khan
The development and advancement of next generation sequencing have not only sped up the process of identifying rare variants, but have also enabled scientists to explore all variants in a single individual. The Pakistani population has a high ratio of first degree consanguinity, which is why it is a rich source for various kinds of genetic disorders. Due to the heterogeneous composition of Pakistani population, the likelihood of genetic heterogeneity for each disorder is high. Therefore, the compilation and organization of such vast genetic data is necessary to facilitate access for analysis and interpretation to researchers and medical geneticists...
December 6, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29223499/a-comparison-of-standard-versus-low-dose-heparin-on-access-related-complications-after-coronary-angiography-through-radial-access-a-meta-analysis-of-randomized-controlled-trials
#7
Khagendra Dahal, Sharan Sharma, Adil Yousuf, Juyong Lee, Michael Azrin, Enrique Jimenez, Kalgi Modi, Neeraj Tandon
BACKGROUND: Transradial access (TRA) is preferred for coronary angiography (CA) or percutaneous coronary intervention due to reduced access-related complications, and mortality especially for patients with ST elevation myocardial infarction. Radial artery occlusion (RAO) is a known complication of TRA, and precludes its use as a future access site, conduit for coronary artery bypass grafting or for hemodialysis fistula placement. Although a standard dose (SD) heparin of 5000 Units is used during TRA, the risks of RAO and hematoma compared to lower dose (LD) remain unclear...
November 5, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29222770/ocular-nerve-growth-factor-ngf-and-ngf-eye-drop-application-as-paradigms-to-investigate-ngf-neuroprotective-and-reparative-actions
#8
Paola Tirassa, Pamela Rosso, Angela Iannitelli
The eye is a central nervous system structure that is uniquely accessible to local treatment. Through the ocular surface, it is possible to access the retina, optic nerve, and brain. Animal models of retina degeneration or optic nerve crush could thus serve as tools to investigate whether and how factors, which are anterogradely or retrogradely transported through the optic nerve, might contribute to activate neuroprotection and eventually regeneration. Among these factors, nerve growth factor (NGF) plays a crucial role during development of the visual system, as well as during the entire life span, and in pathological conditions...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222306/therapy-of-primary-cns-lymphoma-role-of-intensity-radiation-and-novel-agents
#9
REVIEW
Andrés José María Ferreri
Primary central nervous system (CNS) lymphomas represent a subgroup of malignancies with specific characteristics, an aggressive course, and unsatisfactory outcome in contrast with other lymphomas comparable for tumor burden and histological type. Despite the high sensitivity to conventional chemotherapy and radiotherapy, remissions are frequently short lasting. Treatment efficacy is limited by several factors, including the biology and microenvironment of this malignancy and the "protective" effect of the blood-brain barrier, which limits the access of most drugs to the CNS...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222070/regulation-of-trna-biogenesis-in-plants-and-its-link-to-plant-growth-and-response-to-pathogens
#10
REVIEW
Adriana Santos Soprano, Juliana Helena Costa Smetana, Celso Eduardo Benedetti
tRNA biology has fascinated scientists over the years. Besides their fundamental role in protein translation, new evidence indicates that tRNA-derived molecules also regulate gene expression and protein synthesis in all domains of life. In this review, we will highlight some of the recent findings linking tRNA transcription and modification with plant cell growth and response to pathogens. In fact, mutations in proteins directly involved in tRNA synthesis and modification most often lead to pleiotropic effects on plant growth and immunity...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29220476/egenpub-a-text-mining-system-for-extending-computationally-mapped-bibliography-for-uniprot-knowledgebase-by-capturing-centrality
#11
Ruoyao Ding, Emmanuel Boutet, Damien Lieberherr, Michel Schneider, Michael Tognolli, Cathy H Wu, K Vijay-Shanker, Cecilia N Arighi
UniProt Knowledgebase (UniProtKB) is a publicly available database with access to a vast amount of protein sequence and functional information. To widen the scope of the publications associated with a protein entry, UniProt has introduced the computationally mapped additional bibliography section, which includes literature collected from external sources. In this article, we describe a text mining system, eGenPub, which selects articles that are 'about' specific proteins and allows automatic identification of additional bibliography for given UniProt protein entries...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29218887/a-heuristic-method-for-simulating-open-data-of-arbitrary-complexity-that-can-be-used-to-compare-and-evaluate-machine-learning-methods
#12
Jason H Moore, Maksim Shestov, Peter Schmitt, Randal S Olson
A central challenge of developing and evaluating artificial intelligence and machine learning methods for regression and classification is access to data that illuminates the strengths and weaknesses of different methods. Open data plays an important role in this process by making it easy for computational researchers to easily access real data for this purpose. Genomics has in some examples taken a leading role in the open data effort starting with DNA microarrays. While real data from experimental and observational studies is necessary for developing computational methods it is not sufficient...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218002/xenopus-laevis-as-a-model-organism-for-the-study-of-spinal-cord-formation-development-function-and-regeneration
#13
REVIEW
Laura N Borodinsky
The spinal cord is the first central nervous system structure to develop during vertebrate embryogenesis, underscoring its importance to the organism. Because of its early formation, accessibility to the developing spinal cord in amniotes is challenging, often invasive and the experimental approaches amenable to model systems like mammals are limited. In contrast, amphibians, in general and the African-clawed frog Xenopus laevis, in particular, offer model systems in which the formation of the spinal cord, the differentiation of spinal neurons and glia and the establishment of spinal neuron and neuromuscular synapses can be easily investigated with minimal perturbations to the whole organism...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29216858/use-of-a-hydrophilic-coating-wire-reduces-significantly-the-rate-of-central-vein-punctures-and-the-incidence-of-pneumothorax-in-totally-implantable-access-port-tiap-surgery
#14
Georgios Polychronidis, Roland Hennes, Cosima Engerer, Phillip Knebel, Daniel Schultze, Thomas Bruckner, Beat P Müller-Stich, Lars Fischer
No abstract text is available yet for this article.
December 7, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29215053/selective-carbon-dioxide-sorption-and-heterogeneous-catalysis-by-a-new-3d-zn-mof-with-nitrogen-rich-1d-channels
#15
Hyun-Chul Kim, Seong Huh, Sung-Jin Kim, Youngmee Kim
We prepared a new C 2h-symmetric bridging ligand, 3,3'-(pyrazine-2,5-diyl)dibenzoic acid (3,3'-PDBA), through a Suzuki coupling reaction. 3,3'-PDBA contains a central pyrazine ring instead of the phenyl ring of 3,3'-terphenyldicarboxylic acid (3,3'-TPDC). Despite the geometrical similarity of the two bridging ligands, the reaction between Zn(NO3)2·6H2O and 3,3'-PDBA in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) yielded a structurally different Zn-based metal-organic framework (Zn-MOF). The Zn-MOF, [Zn2(3,3'-PDBA)2(DABCO)1...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212418/clinical-characteristics-and-outcome-of-childhood-acute-promyelocitic-leukemia-apl-in-saudi-arabia-a-multicenter-saphos-leukemia-group-study
#16
Wasil Jastaniah, Abdulrahman Alsultan, Saad Al Daama, Walid Ballourah, Mohamed Bayoumy, Faisal Al-Anzi, Omar Al Shareef, Mohammed Burhan Abrar, Reem Al Sudairy, Ibrahim Al Ghemlas
BACKGROUND: Acute promyelocytic leukemia (APL) is a rare form of acute myelogenous leukemia (AML). Survival rates exceed 80% in developed countries. Successful treatments rely on all-trans retinoic acid with anthracycline-based chemotherapy. Availability of modern care and public knowledge play important roles in pediatric APL survival. METHOD: A cytogenetic diagnosis of APL was confirmed in 30 (14.5%) out of 207 children consecutively diagnosed with de novo AML between January 2005 and December 2012 at nine cancer care centers in Saudi Arabia...
December 7, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29211793/assessing-infection-control-practices-to-protect-health-care-workers-and-patients-in-malawi-from-nosocomial-transmission-of-mycobacterium-tuberculosis
#17
Robert J Flick, Adamson Munthali, Katherine Simon, Mina Hosseinipour, Maria H Kim, Lameck Mlauzi, Peter N Kazembe, Saeed Ahmed
Transmission of Mycobacterium tuberculosis (TB) in health settings threatens health care workers and people living with HIV in sub-Saharan Africa. Nosocomial transmission is reduced with implementation of infection control (IC) guidelines. The objective of this study is to describe implementation of TB IC measures in Malawi. We conducted a cross-sectional study utilizing anonymous health worker questionnaires, semi-structured interviews with facility managers, and direct observations at 17 facilities in central Malawi...
2017: PloS One
https://www.readbyqxmd.com/read/29211713/runx3-programs-cd8-t-cell-residency-in-non-lymphoid-tissues-and-tumours
#18
J Justin Milner, Clara Toma, Bingfei Yu, Kai Zhang, Kyla Omilusik, Anthony T Phan, Dapeng Wang, Adam J Getzler, Toan Nguyen, Shane Crotty, Wei Wang, Matthew E Pipkin, Ananda W Goldrath
Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune responses. However, the molecular signals that control TRM cell differentiation and homeostasis are not fully understood. Here we show that mouse TRM precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory cell populations at the levels of gene expression and chromatin accessibility. Using computational and pooled in vivo RNA interference screens, we identify the transcription factor Runx3 as a key regulator of TRM cell differentiation and homeostasis...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29211161/profile-of-demand-and-continuous-cash-benefits-bcp-granted-to-children-diagnosed-with-microcephaly-in-brazil
#19
Éverton Luís Pereira, Josierton Cruz Bezerra, Jonas Lotufo Brant, Wildo Navegantes de Araújo, Leonor Maria Pacheco Santos
The Brazilian Federal Constitution of 1988 introduced the Continuous Cash Benefits (BCP), allowing the inclusion of people with disabilities. This is a descriptive study with aggregate municipal data about the time and geographic distribution of the incidence of microcephaly related to the Zika virus in Brazil and data of the BCP grants to children diagnosed with microcephaly. Data on the demand and BCP grants to children with microcephaly since 2009 are shown. Cases of microcephaly and/or central nervous system disorders were obtained from the Ministry of Health and totaled 2,366 confirmed cases from January 1, 2015 to December 31, 2016...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29211156/street-level-bureaucracy-and-social-policy-in-brazil
#20
Nilson do Rosário Costa
This paper describes the Brazilian central government bureaucracy and people with disabilities' access to the Continuous Cash Benefit (BPC). This access depends on the Ministry of Social Security bureaucracy's evaluation of the condition of vulnerability. We performed a literature review, analysis of secondary data from time series and cross-sectional data to describe street-level federal bureaucracy. Legal documents and indicators describe the expert evaluation regimen of the Ministry of Social Security (MPS)...
November 2017: Ciência & Saúde Coletiva
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