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https://www.readbyqxmd.com/read/28822403/inpatient-peripherally-inserted-central-venous-catheter-complications-should-peripherally-inserted-central-catheter-lines-be-placed-in-the-intensive-care-unit-setting
#1
Michael Martyak, Ishraq Kabir, Rebecca Britt
Peripherally inserted central venous catheters (PICCs) are now commonly used for central access in the intensive care unit (ICU) setting; however, there is a paucity of data evaluating the complication rates associated with these lines. We performed a retrospective review of all PICCs placed in the inpatient setting at our institution during a 1-year period from January 2013 to December 2013. These were divided into two groups: those placed at the bedside in the ICU and those placed by interventional radiology in non-ICU patients...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28821988/presentation-and-management-of-symptomatic-central-bone-cement-embolization
#2
Ahmed Samir Barakat, Tamer Owais, Mohamed Alhashash, Mootaz Shousha, Hesham El Saghir, Bernward Lauer, Heinrich Boehm
BACKGROUND CONTEXT: With more cement augmentation procedures done, the occurrence of serious complications is also expected to rise. Symptomatic central cement embolization is a rare but very serious complication. Moreover, the pathophysiology and treatment of intrathoracic cement embolism remain controversial. PURPOSE: In this case series, we are trying to identify various presentations and suggest our emergent management scheme for symptomatic central cement embolization...
August 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28820231/interventions-for-treating-persistent-pain-in-survivors-of-torture
#3
REVIEW
Emma Baird, Amanda C de C Williams, Leslie Hearn, Kirstine Amris
BACKGROUND: Persistent (chronic) pain is a frequent complaint in survivors of torture, particularly but not exclusively pain in the musculoskeletal system. Torture survivors may have no access to health care; where they do, they may not be recognised when they present, and the care available often falls short of their needs. There is a tendency in state and non-governmental organisations' services to focus on mental health, with poor understanding of persistent pain, while survivors may have many other legal, welfare, and social problems that take precedence over health care...
August 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28819317/intradialytic-central-venous-oxygen-saturation-is-associated-with-clinical-outcomes-in-hemodialysis-patients
#4
Lili Chan, Hanjie Zhang, Anna Meyring-Wösten, Israel Campos, Doris Fuertinger, Stephan Thijssen, Peter Kotanko
Central venous oxygen saturation (ScvO2) in the superior vena cava is predominantly determined by cardiac output, arterial oxygen content, and oxygen consumption by the upper body. While abnormal ScvO2 levels are associated with morbidity and mortality in non-uremic populations, ScvO2 has received little attention in hemodialysis patients. From 1/2012 to 8/2015, 232 chronic hemodialysis patients with central venous catheters as vascular access had their ScvO2 monitored during a 6-month baseline period and followed for up to 36 months...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817131/connective-tissue-graft-wall-technique-and-enamel-matrix-derivative-for-the-treatment-of-infrabony-defects-case-reports
#5
Giovanni Zucchelli, Lham Mounssif, Matteo Marzadori, Claudio Mazzotti, Pietro Felice, Martina Stefanini
The present case report describes a modification of the connective tissue graft wall technique with enamel matrix derivative applied to treat deep vertical bony defects. The technique presented uses a palatal incision to gain access to the bony defect. Deep infrabony defects affecting two maxillary central incisors associated with interdental and buccal gingival recession were treated. At 1 year after surgery, 9 and 6 mm of interdental clinical attachment level gain were seen in cases 1 and 2, respectively...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28816407/direct-and-stereospecific-3-2-synthesis-of-pyrrolidines-from-simple-unactivated-alkenes
#6
Jorge Otero-Fraga, Samuel Suárez-Pantiga, Marc Montesinos-Magraner, Dennis Rhein, Abraham Mendoza
Pyrrolidines are central heterocyclic compounds with endless applications in organic synthesis, metal- and organocatalysis. In particular, their potential as ligands for first-row transition-metal catalysts has inspired a new method to access complex poly-heterocyclic pyrrolidines in one-step from available materials. This fundamental step forward is grounded on the discovery of an essential organoaluminum promoter that engages unactivated and electron-rich olefins in intermolecular [3+2] cycloadditions for the first time...
August 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28815975/urea-based-recirculation-validation-of-the-symmetrical-palindrome-catheter
#7
Martin Jonczyk, Christian Althoff, Torsten Slowinski, Ina Lieker, Marcel Naik, Jonas Auer, Raúl García Marcos, Ejona Duka, Bernd Hamm, Maximilian de Bucourt
BACKGROUND: High blood flow and low recirculation rates are central for adequate haemodialysis. A new symmetrical tip has been invented promising efficient haemodialysis even if the ports are reversed. OBJECTIVE: To evaluate access recirculation of the 'palindrome' catheter and to report initial experiences in a clinical setting. MATERIAL AND METHODS: After implantation of the new catheter in 20 patients (male: 14; female: 6; mean age 72 ± 12...
August 16, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28812965/meeting-the-communication-support-needs-of-children-and-young-people-with-intellectual-disabilities-in-the-bolivian-andes
#8
Susan Buell, Darren Chadwick
Services available for people with disabilities in Bolivia tend to be fragmented and costly. Children and adults with intellectual disabilities are more likely to have a related communication disability and are thus both literally and metaphorically excluded from having a voice. The following research aimed to explore the experiences of accessing services by people with communication disabilities in Bolivia through semi-structured interviews and one focus group carried out with family members, professionals, service providers, educators and policymakers...
September 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/28810986/cancer-incidence-among-patients-of-the-u-s-veterans-affairs-health-care-system-2010-update
#9
Leah L Zullig, Kellie J Sims, Rebecca McNeil, Christina D Williams, George L Jackson, Dawn Provenzale, Michael J Kelley
INTRODUCTION: Nearly 50,000 incident cancer cases are reported in Veterans Affairs (VA) Central Cancer Registry (VACCR) annually. This article provides an updated report of cancer incidence recorded in VACCR. MATERIALS AND METHODS: Data were obtained from VACCR for incident cancers diagnosed in the VA health care system, focusing on 2010 data. Cancer incidence among VA patients is described by anatomical site, sex, race, stage, and geographic location, and was compared to the general U...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810443/disgust-shame-and-the-psychosocial-impact-of-skin-picking-evidence-from-an-online-support-forum
#10
Suzy Anderson, Victoria Clarke
This article examines the accounts of individuals who problematically pick their skin and explores their subjective experiences. In total, 100 problem disclosure statements were taken from posts made to a publicly accessible online skin picking support forum. These posts were systematically analysed using thematic analysis. Themes of disgust, shame and psychosocial avoidance dominated the analysis and appeared central to the experience of skin picking. Skin picking was shown to be a heterogeneous experience with a complex emotional profile...
April 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810175/time-trends-for-prostate-cancer-mortality-in-brazil-and-its-geographic-regions-an-age-period-cohort-analysis
#11
Sonia Faria Mendes Braga, Mirian Carvalho de Souza, Mariangela Leal Cherchiglia
BACKGROUND: In the 1980s, an increase in mortality rates for prostate cancer was observed in North America and developed European countries. In the 1990s, however, mortality rates decreased for these countries, an outcome related to early detection of the disease. Conversely, an upward trend in mortality rates was observed in Brazil. This study describe the trends in mortality for prostate cancer in Brazil and geographic regions (North, Northeast, South, Southeast, and Central-West) between 1980 until 2014 and analyze the influence of age, period, and cohort effects on mortality rates...
August 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28808056/the-crystal-structure-of-full-length-sizzled-from-xenopus-laevis-yields-insights-into-wnt-antagonistic-function-of-secreted-frizzled-related-proteins
#12
Qixin Bu, Zhiqiang Li, Junying Zhang, Fei Xu, Jianmei Liu, Heli Liu
The Wnt signaling pathway is crucial to cell proliferation, differentiation and migration. The secreted frizzled-related proteins (sFRPs) represent the largest family of secreted Wnt inhibitors. However, their function in antagonizing Wnt signaling has remained somewhat controversial. Here we report the crystal structure of Sizzled from Xenopus laevis, the first full-length structure of an sFRP. Tethered by an inter-domain disulfide bond and a linker, the N-terminal CRD domain and the C-terminal NTR domain of Sizzled are arranged in a tandem fashion, with the NTR domain occluding the groove of CRD for Wnt accessibility...
August 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28807658/self-reported-participation-in-voluntary-nonprescription-syringe-sales-in-california-s-central-valley
#13
Robin A Pollini
OBJECTIVES: California Senate Bill 41 (SB41), effective January 2012, is a human immunodeficiency virus/hepatitis C virus prevention measure designed to expand syringe access among injection drug users (IDUs) by allowing pharmacies to sell syringes without a prescription. This study assesses self-reported implementation of SB41 and characterizes barriers amenable to intervention. DESIGN: Interviewer-administered survey. SETTING AND PARTICIPANTS: Fresno and Kern Counties, CA...
August 11, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28807507/optimizing-arthroscopy-for-osteochondral-lesions-of-the-talus-the-effect-of-ankle-positions-and-distraction-during-anterior-and-posterior-arthroscopy-in-a-cadaveric-model
#14
Phinit Phisitkul, Craig C Akoh, Chamnanni Rungprai, Alexej Barg, Annuziato Amendola, Kevin Dibbern, Donald Anderson
PURPOSE: To quantify arthroscopic accessibility of the talar dome with predefined ankle positions through anterior and posterior approaches. METHODS: Fourteen below-knee cadaver specimens underwent preoperative range of motion assessments. A 30° 2.7-mm arthroscopic camera was used to mark accessible areas at varying ankle positions. Accessible regions were quantified using a surface laser scanner and digital 3 × 3 grid. Statistical analyses were performed to detect differences in arthroscopic accessibility between different flexion angles and noninvasive distraction...
August 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28806858/the-haemtrack-home-therapy-reporting-system-design-implementation-strengths-and-weaknesses-a-report-from-uk-haemophilia-centre-doctors-organisation
#15
C R M Hay, H Xiang, M Scott, P W Collins, R Liesner, G Dolan, R Hollingsworth
INTRODUCTION: Haemtrack is an electronic home treatment diary for patients with inherited bleeding disorders, introduced in 2008. It aimed to improve the timeliness and completeness of patient-reported treatment records, to facilitate analysis of treatment and outcome trends. The system is easy to use, responsive and accessible. METHODS: The software uses Microsoft technologies with a SQL Server database and an ASP.net website front-end, running on personal computers, android and I-phones...
August 14, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28806225/preventing-retained-central-venous-catheter-guidewires-a-randomized-controlled-simulation-study-using-a-human-factors-approach
#16
Maryanne Z A Mariyaselvam, Ken R Catchpole, David K Menon, Arun K Gupta, Peter J Young
BACKGROUND: Retained central venous catheter guidewires are never events. Currently, preventative techniques rely on clinicians remembering to remove the guidewire. However, solutions solely relying upon humans to prevent error inevitably fail. A novel locked procedure pack was designed to contain the equipment required for completing the procedure after the guidewire should have been removed: suture, suture holder, and antimicrobial dressings. The guidewire is used as a key to unlock the pack and to access the contents; thereby, the clinician must remove the guidewire from the patient to complete the procedure...
August 11, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28806219/selective-activation-of-basal-forebrain-cholinergic-neurons-attenuates-polymicrobial-sepsis-induced-inflammation-via-the-cholinergic-anti-inflammatory-pathway
#17
Qian Zhai, Dengming Lai, Ping Cui, Rui Zhou, Qixing Chen, Jinchao Hou, Yunting Su, Libiao Pan, Hui Ye, Jing-Wei Zhao, Xiangming Fang
OBJECTIVES: Basal forebrain cholinergic neurons are proposed as a major neuromodulatory system in inflammatory modulation. However, the function of basal forebrain cholinergic neurons in sepsis is unknown, and the neural pathways underlying cholinergic anti-inflammation remain unexplored. DESIGN: Animal research. SETTING: University research laboratory. SUBJECTS: Male wild-type C57BL/6 mice and ChAT-ChR2-EYFP (ChAT) transgenic mice...
August 10, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28806134/ilir-viral-a-web-resource-for-lir-motif-containing-proteins-in-viruses
#18
Anne-Claire Jacomin, Siva Samavedam, Hannah Charles, Ioannis P Nezis
Macroautophagy/autophagy has been shown to mediate the selective lysosomal degradation of pathogenic bacteria and viruses (xenophagy), and to contribute to the activation of innate and adaptative immune responses. Autophagy can serve as an antiviral defense mechanism but also as a pro-viral process during infection. Atg8-family proteins play a central role in the autophagy process due to their ability to interact with components of the autophagy machinery as well as selective autophagy receptors and adaptor proteins...
August 14, 2017: Autophagy
https://www.readbyqxmd.com/read/28805300/the-kidney-allocation-system-does-not-appropriately-stratify-risk-of-pediatric-donor-kidneys-implications-for-pediatric-recipients
#19
S M Nazarian, A W Peng, B Duggirala, M Gupta, T Bittermann, S Amaral, M H Levine
Kidney Allocation System (KAS) was enacted in 2014 to improve graft utility, while facilitating transplantation of highly-sensitized patients and preserving pediatric access to high-quality kidneys. Central to this system is the Kidney Donor Profile Index (KDPI), a metric intended to predict transplant outcomes based on donor characteristics but derived using only adult donors. We posited that KAS had inadvertently altered the profile and quantity of kidneys made available to pediatric recipients. This question arose from our observation that most pediatric donors carry a KDPI over 35 and have therefore been rendered relatively inaccessible to pediatric recipients under KAS...
August 14, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28803997/the-impact-of-distance-from-transplant-unit-on-outcomes-following-kidney-transplantation
#20
Anna Powell-Chandler, Usman Khalid, Szabolcs Horvath, Mohamed A Ilham, Argiris Asderakis, Michael R Stephens
BACKGROUND: Following transplantation, many patients travel long distances for follow-up care. Many studies have examined the influence of distance from transplant centre on access to transplantation, but few have examined post-transplant outcomes. MATERIALS AND METHODS: Distance from transplant centre was calculated for all kidney transplant recipients transplanted over a 5-year period. Outcomes measured were rates of acute rejection, graft and patient survival...
August 10, 2017: International Journal of Surgery
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