keyword
MENU ▼
Read by QxMD icon Read
search

Central access

keyword
https://www.readbyqxmd.com/read/29036653/mircarta-a-central-repository-for-collecting-mirna-candidates
#1
Christina Backes, Tobias Fehlmann, Fabian Kern, Tim Kehl, Hans-Peter Lenhof, Eckart Meese, Andreas Keller
The continuous increase of available biological data as consequence of modern high-throughput technologies poses new challenges for analysis techniques and database applications. Especially for miRNAs, one class of small non-coding RNAs, many algorithms have been developed to predict new candidates from next-generation sequencing data. While the amount of publications describing novel miRNA candidates keeps steadily increasing, the current gold standard database for miRNAs - miRBase - has not been updated since June 2014...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036542/database-resources-of-the-big-data-center-in-2018
#2
(no author information available yet)
The BIG Data Center at Beijing Institute of Genomics (BIG) of the Chinese Academy of Sciences provides freely open access to a suite of database resources in support of worldwide research activities in both academia and industry. With the vast amounts of omics data generated at ever-greater scales and rates, the BIG Data Center is continually expanding, updating and enriching its core database resources through big-data integration and value-added curation, including BioCode (a repository archiving bioinformatics tool codes), BioProject (a biological project library), BioSample (a biological sample library), Genome Sequence Archive (GSA, a data repository for archiving raw sequence reads), Genome Warehouse (GWH, a centralized resource housing genome-scale data), Genome Variation Map (GVM, a public repository of genome variations), Gene Expression Nebulas (GEN, a database of gene expression profiles based on RNA-Seq data), Methylation Bank (MethBank, an integrated databank of DNA methylomes), and Science Wikis (a series of biological knowledge wikis for community annotations)...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036464/the-mimic-code-repository-enabling-reproducibility-in-critical-care-research
#3
Alistair E W Johnson, David J Stone, Leo A Celi, Tom J Pollard
Objective: Lack of reproducibility in medical studies is a barrier to the generation of a robust knowledge base to support clinical decision-making. In this paper we outline the Medical Information Mart for Intensive Care (MIMIC) Code Repository, a centralized code base for generating reproducible studies on an openly available critical care dataset. Materials and Methods: Code is provided to load the data into a relational structure, create extractions of the data, and reproduce entire analysis plans including research studies...
September 27, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29035118/clinical-gene-therapy-for-neurodegenerative-diseases-past-present-and-future
#4
Françoise Piguet, Sandro Alves, Nathalie Cartier
Clinical gene therapy has made important advances over the last decade. Among neurological diseases, severe genetic neurodegenerative conditions have been the focus of initial clinical applications. Gene therapy has also addressed complex neurodegenerative diseases, particularly Parkinson's disease, with encouraging results in human patients, demonstrating that specific targeting of central nervous system (CNS) cells is a relevant strategy for severe pathologies and that efficient access to the CNS with viral vectors is an achievable goal...
November 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29034545/a-pilot-intervention-to-reduce-postpartum-weight-retention-and-central-adiposity-in-first-time-mothers-results-from-the-mums-online-online-lifestyle-nutrition-exercise-study
#5
P van der Pligt, K Ball, K D Hesketh, M Teychenne, D Crawford, P J Morgan, C E Collins, K J Campbell
BACKGROUND: Postpartum weight retention (PPWR) increases the risk for obesity and complications during subsequent pregnancies. Few interventions have been successful in limiting PPWR in mothers. The present study assessed the effectiveness of the mums OnLiNE (Online, Lifestyle, Nutrition & Exercise) intervention with respect to reducing PPWR and improving diet, physical activity and sedentary behaviour. METHODS: A subsample of first-time mothers enrolled in the Extended Melbourne Infant Feeding Activity and Nutrition Trial (InFANT Extend) completed the nonrandomised mums OnLiNE intervention...
October 16, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29034281/systematic-review-of-the-safety-and-efficacy-of-contrast-injection-via-venous-catheters-for-contrast-enhanced-computed-tomography
#6
REVIEW
S B Buijs, M W Barentsz, M L J Smits, J W C Gratama, P E Spronk
OBJECTIVE: To examine the safety and efficacy of contrast injection through a central venous catheter (CVC) for contrast-enhanced computed tomography (CECT). METHODS: A systematic literature search was performed using PubMed. Studies were deemed eligible if they reported on the use of CVCs for contrast administration. Selected articles were assessed for their relevance and risk of bias. Articles with low relevance and high risk of bias or both were excluded. Data from included articles was extracted...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29034170/changes-over-time-in-population-level-transport-satisfaction-and-mode-of-travel-a-13-year-repeat-cross-sectional-study-uk
#7
Jonathan R Olsen, Laura Macdonald, Anne Ellaway
AIM: The aim of the study was to examine changes over time in satisfaction with usual transport mode, explore individual and area level characteristics as mediators in the likelihood of transport satisfaction, and whether any changes in transport satisfaction varied by these factors over time. METHODS: Adults from West Central Scotland, United Kingdom, who participated at both waves of the repeat cross-sectional 'Transport, Health and Well-being Study' conducted in 1997 (n=2735) and 2010 (n=2024) were assessed...
September 2017: Journal of Transport & Health
https://www.readbyqxmd.com/read/29034015/a-new-technique-for-femoral-venous-access-in-infants-using-arterial-injection-venous-return-guidance
#8
Hironori Ebishima, Masataka Kitano, Kenichi Kurosaki, Isao Shiraishi
Objectives: Although venography guidance is helpful for central venous catheter placement, it is sometimes difficult to place a peripheral intravenous cannula for enhancement. We designed a new technique for establishing femoral venous access using venography guidance in the return phase of peripheral arteriography. This new technique was named arterial injection venous return guidance. Here we assessed the efficacy and safety of arterial injection venous return guidance. Methods: We reviewed data of 29 infants less than 6 months old undergoing catheter intervention at our institute in 2014...
March 24, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032632/linking-agriculture-and-nutrition-education-to-improve-infant-and-young-child-feeding-lessons-for-future-programmes
#9
Ellen Muehlhoff, Ramani Wijesinha-Bettoni, Elizabeth Westaway, Theresa Jeremias, Stacia Nordin, Julia Garz
Agriculture and food systems play a central role in nutrition by supplying nutritious, healthy and affordable foods. When integrated with nutrition education for behaviour change, agricultural interventions that supply diverse affordable foods from all food groups have great scope for improving young child and family diets. In 2014, process reviews were conducted in Cambodia and Malawi of food security projects that provided agricultural support and community-based nutrition education on improved infant and young child feeding (IYCF)...
October 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29031003/step-by-step-calculation-and-spreadsheet-tools-for-predicting-stressor-levels-that-extirpate-genera-and-species
#10
Susan M Cormier, Lei Zheng, Erik W Leppo, Andrew Hamilton
In 2011, the U.S. Environmental Protection Agency (USEPA) released a field-based method for estimating the extirpation of freshwater aquatic benthic invertebrates by ionic mixtures dominated by HCO3(-) , SO4(2-) , and Ca(2+) measured as specific conductivity (SC). The estimate of extirpation was SC at the 95(th) centile (XC95 ) of a weighted cumulative frequency distribution (CFD) of a genus or species over a range of SC. A CFD of XC95 values was used to predict the SC at which 5% of genera were likely to be extirpated...
October 14, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29029626/higher-educational-attainment-associated-with-reduced-likelihood-of-abnormal-cervical-lesions-among-zambian-women-a-cross-sectional-study
#11
Twaambo Euphemia Hamoonga, Rosemary Ndonyo Likwa, Patrick Musonda, Charles Michelo
BACKGROUND: The high burden of cervical cancer in Zambia prompted the Ministry of Health and partners to develop the cervical cancer prevention program in Zambia (CCPPZ) in 2006. Despite this intervention more women continue to die from the disease and there is little understanding of factors that may be linked with abnormal cervical lesions in the general population. We therefore examined if educational attainment is associated with abnormal cervical lesions among Zambian women aged 15 to 49 years...
October 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29028882/enzymatic-methods-for-genome-wide-profiling-of-protein-binding-sites
#12
Robert A Policastro, Gabriel E Zentner
Genome-wide mapping of protein-DNA interactions is a staple approach in many areas of modern molecular biology. Genome-wide profiles of protein-binding sites are most commonly generated by chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq). Although ChIP-seq has played a central role in studying genome-wide protein binding, recent work has highlighted systematic biases in the technique that warrant technical and interpretive caution and underscore the need for orthogonal techniques to both confirm the results of ChIP-seq studies and uncover new insights not accessible to ChIP...
October 6, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29028747/nervous-system-delivery-of-antilysophosphatidic-acid-antibody-by-nasal-application-attenuates-mechanical-allodynia-after-traumatic-brain-injury-in-rats
#13
Andreas Eisenried, Anders C N Meidahl, Michael Klukinov, Alexander Z Tzabazis, Roger A Sabbadini, J David Clark, David C Yeomans
Lysophosphatidic acid (LPA) is a bioactive lipid that impacts neurological outcomes after neurotrauma by inhibiting neuroregeneration, promoting inflammation, and contributing to behavioral deficits. Blocking LPA signaling with a novel anti-LPA monoclonal antibody (mAb) is neuroprotective after traumatic brain injury (TBI) if given to injured animals whose blood-brain barrier (BBB) has been compromised. It is hypothesized that the anti-LPA mAb could improve chronic pain initiated by TBI. However, poor brain penetration after systemic application of the antibody makes access to the central nervous system (CNS) problematic in situations where the BBB is intact...
November 2017: Pain
https://www.readbyqxmd.com/read/29028239/nordic-paradox-southern-miracle-eastern-disaster-persistence-of-inequalities-in-mortality-in-europe
#14
Johan P Mackenbach
The persistence of socioeconomic inequalities in health, despite all that has been done to reduce social and economic inequalities in many European countries, is one of the great disappointments of public health. In this paper, I summarize the results of a series of studies into the explanation of variations and trends in inequalities in mortality in three European regions: the Nordic countries with their puzzlingly large inequalities in mortality, Southern European countries with their miraculously small inequalities in mortality and Central & Eastern European countries in which inequalities in mortality have disastrously exploded since the early 1990 s...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29027182/preoperative-management-of-arteriovenous-fistula-avf-for-hemodialysis
#15
Gaetano Alfano, Francesco Fontana, Mario Iannaccone, Patrizia Noussan, Gianni Cappelli
Native arteriovenous fistula (AVF) is the favorite access for hemodialysis (HD). The National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) recommends its creation in most patients with renal failure. Unfortunately, intensive efforts to promote native AVF in patients with marginal vessels have increased the rate of primary fistula failure. A non-functioning fistula prompts the use of central venous catheter (CVC) that, unlike AVF, has been associated with an increased risk of morbidity and mortality among patients receiving HD...
October 11, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29026396/willingness-by-people-living-with-hiv-aids-to-utilize-hiv-services-provided-by-village-health-team-workers-in-kalungu-district-central-uganda
#16
Mutaawe Lubogo, Ronald Anguzu, Humphrey Wanzira, Irene Namugwanya, Oliver Namuddu, Denis Ssali, Sylivia Nanyonga, Josephine Ssentongo, Janet Seeley
BACKGROUND: Less than one quarter of people in need have access to HIV services in Uganda. This study assessed willingness of people living with HIV/AIDS (PLWHAs) to utilize HIV services provided by Village Health Teams (VHTs) in Kalungu district, central Uganda. METHODS: A cross-sectional study conducted in two health facilities providing anti-retroviral therapy enrolled 312 PLWHAs. Pre-tested semi-structured questionnaires were administered to participants at household level...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29026198/ctbp2-mediated-%C3%AE-catenin-regulation-is-required-for-exit-from-pluripotency
#17
Tae Wan Kim, Sojung Kwak, Jihoon Shin, Byung-Hee Kang, Sang-Eun Lee, Min Young Suh, Jae-Hwan Kim, In-Young Hwang, Jong-Hyuk Lee, Jinmi Choi, Eun-Jung Cho, Hong-Duk Youn
The canonical Wnt pathway is critical for embryonic stem cell (ESC) pluripotency and aberrant control of β-catenin leads to failure of exit from pluripotency and lineage commitments. Hence, maintaining the appropriate level of β-catenin is important for the decision to commit to the appropriate lineage. However, how β-catenin links to core transcription factors in ESCs remains elusive. C-terminal-binding protein (CtBP) in Drosophila is essential for Wnt-mediated target gene expression. In addition, Ctbp acts as an antagonist of β-catenin/TCF activation in mammals...
October 13, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29025446/inefficient-procurement-processes-undermine-access-to-medicines-in-the-western-cape-province-of-south-africa
#18
Bvudzai P Magadzire, Kim Ward, Henry M J Leng, David Sanders
BACKGROUND: South Africa (SA) has experienced several stock-outs of life-saving medicines for the treatment of major chronic infectious and non-communicable diseases in the public sector. OBJECTIVE: To identify the causes of stock-outs and to illustrate how they undermine access to medicines (ATM) in the Western Cape Province, SA. METHODS: This qualitative study was conducted with a sample of over 70 key informants (frontline health workers, sub-structure and provincial health service managers)...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29025415/genetic-evidence-of-multiple-invasions-and-a-small-number-of-founders-of-asian-palmyra-palm-borassus-flabellifer-in-thailand
#19
Kwanjai Pipatchartlearnwong, Akarapong Swatdipong, Supachai Vuttipongchaikij, Somsak Apisitwanich
BACKGROUND: Borassus flabellifer or Asian Palmyra palm is an important crop for local economies in the South and Southeast Asia for its fruit and palm sugar production. Archeological and historical evidence indicated the presence of this species in Southeast Asia dating back at least 1500 years. B. flabellifer is believed to be originated in Africa, spread to South Asia and introduced into Southeast Asia through commercial routes and dissemination of cultures, however, the nature of its invasion and settlement in Thailand is unclear...
October 12, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29023798/intrathecal-antibody-distribution-in-the-rat-brain-surface-diffusion-perivascular-transport-and-osmotic-enhancement-of-delivery
#20
Michelle E Pizzo, Daniel J Wolak, Niyanta N Kumar, Eric Brunette, Christina L Brunnquell, Melanie-Jane Hannocks, N Joan Abbott, M Elizabeth Meyerand, Lydia Sorokin, Danica B Stanimirovic, Robert G Thorne
The precise mechanisms governing the central distribution of macromolecules from the cerebrospinal fluid (CSF) to the brain and spinal cord remain poorly understood, despite their importance for physiological processes such as antibody trafficking for central immune surveillance as well as several ongoing intrathecal clinical trials. Here, we clarify how immunoglobulin G (IgG) and smaller single-domain antibodies (sdAb) distribute throughout the whole brain in a size-dependent manner after intrathecal infusion in rats using ex vivo fluorescence and in vivo 3D magnetic resonance imaging...
October 12, 2017: Journal of Physiology
keyword
keyword
84549
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"