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https://www.readbyqxmd.com/read/28222572/effects-of-exercise-on-learning-and-memory-oxidative-stress-and-nnos-expression-in-marginal-division-of-striatum-of-the-ovariectomized-rats
#1
Jianmei Cui, Yanlan Guo, Wenyan Yang, Xingrui Zhao, Fang Yu, Wei Tang, Bianhua Pang, Xiaoyun Su
BACKGROUND: Since previous studies have shown that ovariectomy impairs memory and cognition, we investigated whether 8-week treadmill exercise would affect ovariectomy-induced memory deficits and explore the possible mechanisms of physical exercise influencing spatial learning and memory of the ovariectomized rats by detecting the rat's brain free radical metabolism and counting nNOS expression in marginal division of the striatum(MrD). METHODS: 40 female rats were assigned to one of the following groups: SHAM, SHAM+E, OVX and OVX+E group...
February 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28217495/prevalence-of-hypogonadism-in-male-type-2-diabetes-mellitus-patients-with-and-without-coronary-artery-disease
#2
S V Madhu, M Aslam, A J Aiman, A Siddiqui, S Dwivedi
AIM: The present study is carried out to investigate hypogonadism using serum testosterone levels in male Type 2 diabetes mellitus (T2DM) subjects with and without coronary artery disease (CAD). SUBJECTS AND METHODS: A total of 150 age and body mass index-matched male subjects in the age group of 30-70 years were recruited in three groups; Group A - subjects with normal glucose tolerance, Group B - T2DM subjects without CAD, and Group C - T2DM subjects with CAD (n = 50 each group)...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28185659/change-in-maximal-exercise-capacity-is-associated-with-survival-in-men-and-women
#3
Clinton A Brawner, Mouaz H Al-Mallah, Jonathan K Ehrman, Waqas T Qureshi, Michael J Blaha, Steven J Keteyian
OBJECTIVE: To describe the relationship between change in maximal exercise capacity (MEC) over time and risk of all-cause mortality separately in men and women. PATIENTS AND METHODS: Consecutive patients (n=10,854; mean ± SD age, 54±11 years; 43% women; 30% nonwhite) who completed 2 physician-referred exercise tests between January 2, 1991, and May 28, 2009, were identified from the Henry Ford Exercise Testing (FIT) Project. The MEC was quantified in metabolic equivalents of task (METs) calculated from peak workload on a treadmill and adjusted to the equivalent for a 50-year-old man...
February 6, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28177746/preliminary-safety-analysis-of-high-intensity-interval-training-hiit-in-persons-with-chronic-stroke
#4
Daniel L Carl, Pierce Boyne, Bradley Rockwell, Myron Gerson, Jane Khoury, Brett Kissela, Kari Dunning
The purpose of this study was to assess safety via electrocardiographic (ECG), blood pressure (BP), heart rate (HR), and orthopedic responses to 3 different high-intensity interval training (HIIT) protocols in persons with stroke. Eighteen participants (10 male; 61.9 + 8.3 years of age; 5.8 + 4.2 years poststroke) completed a symptom-limited graded exercise test (GXT) with ECG monitoring to screen for eligibility and determine HR peak. The 3 HIIT protocols involved repeated 30 s bursts of treadmill walking at maximum speed alternated with rest periods of 30 s (P30), 1 min (P60), or 2 min (P120)...
November 21, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177724/dose-dependent-decrease-in-mortality-with-no-cognitive-or-muscle-function-improvements-due-to-dietary-egcg-supplementation-in-aged-mice
#5
Brandt D Pence, Tushar K Bhattacharya, Pul Park, Jennifer L Rytych, Jacob M Allen, Yi Sun, Robert H McCusker, Keith W Kelley, Rodney W Johnson, Justin S Rhodes, Jeffrey A Woods
We have previously shown that a diet containing epigallocatechin gallate (EGCG) and beta-alanine is not effective in improving either cognitive or muscle function in aged (18 month) mice (Gibbons et al. Behav Brain Res 2014, Pence et al. Appl Physiol Nutr Metab 2016). However, this diet reduced oxidative stress in the brain, and previous studies using longer-term interventions and other doses have documented beneficial effects in cognitive and muscle function, especially with EGCG. Here we hypothesized that a different dose of EGCG or longer feeding period would be more efficacious in improving cognition...
January 5, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28166650/the-effects-of-exercise-load-during-development-on-oxidative-stress-levels-and-antioxidant-potential-in-adulthood
#6
S Lee, J Hashimoto, T Suzuki, A Satoh
The objective of this study was to elucidate the impact of physical activity during the growth period as well as on oxidative stress and antioxidative potential in adulthood. The experimental animals used were four-week old male Wistar rats, which were randomly divided into three groups. The exercise loads were as follows: control (CON), treadmill exercise (TE), and jumping exercise (JE). The exercise was performed at the same time of day, at a frequency of five days per week, for eight weeks. Derivatives of reactive oxygen metabolites (d-ROSs) and biological antioxidant potential (BAP) were measured during periods of rest prior to commencement of the experiment and after the experiment...
February 6, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28166116/cerebral-blood-flow-responses-to-aquatic-treadmill-exercise
#7
Rhodri Parfitt, Marianne Y Hensman, Samuel J E Lucas
INTRODUCTION: Aquatic treadmills are used as a rehabilitation method for conditions such as spinal cord injury, osteoarthritis and stroke, and can facilitate an earlier return to exercise training for athletes. However, their effect on cerebral blood flow (CBF) responses has not been examined. We tested the hypothesis that aquatic treadmill exercise would augment CBF and lower heart rate compared to land-based treadmill exercise. METHODS: Eleven participants completed incremental exercise (crossover design) starting from walking pace [4 km/h, immersed to iliac crest (aquatic), 6 km/h (land)] and increasing 1 km/h every 2 min up to 10 km/h for aquatic (maximum belt speed) or 12 km/h for land...
February 4, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28163315/effects-of-topical-capsaicin-combined-with-moderate-exercise-on-insulin-resistance-body-weight-and-oxidative-stress-in-hypoestrogenic-obese-rats
#8
J M L Medina-Contreras, J Colado-Velázquez, N L Gómez-Viquez, P Mailloux-Salinas, I Perez-Torres, A Aranda-Fraustro, K Carvajal, G Bravo
BACKGROUND: Hypoestrogenic women are one of the most vulnerable groups for the development of obesity and its complications. Capsaicin and exercise have demonstrated to reduce body weight and to improve insulin sensitivity in different animal models, but it is unknown whether their combination could be useful in hypoestrogenic obese females. METHODS: We investigated whether topical capsaicin, exercise or their combination had better therapeutic effects in an obesity-hypoestrogenism model...
February 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28151505/-a-late-diagnosis-of-left-atrial-myxoma-how-to-gain-time
#9
Ferdinando Maria Massari, Tatiana Tonella, Giuseppe Pomè, Alessandra Di Mauro, Claudio Clemente, Federico Lombardi
A 56-year-old man presented to the Outpatient Cardiology Unit for dyspnea that had been lasting 6 months and an occasional episode of cold perspiration on climbing a flight of stairs. In the suspicion of coronary artery disease, he was prescribed a complete blood panel, an echocardiogram and a treadmill stress test. The echocardiogram, performed as late as 78 days after the first evaluation and only by chance scheduled 2 days before the stress test, enabled a diagnosis of left atrial myxoma for which the patient successfully underwent cardiac surgery...
December 2016: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28145667/acute-coronary-syndrome-diagnostic-evaluation
#10
Craig Barstow, Matthew Rice, Jonathan D McDivitt
Myocardial infarction (MI), a subset of acute coronary syndrome, is damage to the cardiac muscle as evidenced by elevated cardiac troponin levels in the setting of acute ischemia. Coronary artery disease is the leading cause of mortality in the United States. Chest pain is a common presentation in patients with MI; however, there are multiple noncardiac causes of chest pain, and the diagnosis cannot always be made based on initial presentation. The assessment of a possible MI includes evaluation of risk factors and presenting signs and symptoms, rapid electrocardiography, and serum cardiac troponin measurements...
February 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28137660/effects-of-moderate-treadmill-exercise-and-fluoxetine-on-behavioural-and-cognitive-deficits-hypothalamic-pituitary-adrenal-axis-dysfunction-and-alternations-in-hippocampal-bdnf-and-mrna-expression-of-apoptosis-related-proteins-in-a-rat-model-of-post-traumatic
#11
Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pour
Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need for the development of new treatment. Physical activity is known to improve symptoms of certain neuropsychiatric disorders. The present study investigated the effects of moderate treadmill exercise, the antidepressant fluoxetine and the combined treatment on behavioural deficits, and hypothalamic-pituitary-adrenal (HPA) axis dysfunction...
January 28, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28117249/downhill-exercise-training-in-monocrotaline-injected-rats-effects-on-echocardiographic-and-haemodynamic-variables-and-survival
#12
Irina Enache, Fabrice Favret, Stéphane Doutreleau, Paola Goette Di Marco, Anne-Laure Charles, Bernard Geny, Anne Charloux
BACKGROUND: Eccentric exercise training has been shown to improve muscle force strength without excessive cardiovascular stress. Such an exercise modality deserves to be tested in pulmonary arterial hypertension. AIM: We aimed to assess the effects of an eccentric training modality on cardiac function and survival in an experimental monocrotaline-induced model of pulmonary arterial hypertension with right ventricular dysfunction. METHODS: Forty rats were randomly assigned to one of four groups: 40mg/kg monocrotaline-injected sedentary rats; 40mg/kg monocrotaline-injected eccentric-trained rats; sedentary control rats; or eccentric-trained control rats...
January 20, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28107887/associations-between-positive-emotional-well-being-and-stress-induced-myocardial-ischemia-well-being-scores-predict-exercise-induced-ischemia
#13
Jacob P Feigal, Stephen H Boyle, Zainab Samad, Eric J Velazquez, Jennifer L Wilson, Richard C Becker, Redford B Williams, Cynthia M Kuhn, Thomas L Ortel, Joseph G Rogers, Christopher M O'Connor, Wei Jiang
OBJECTIVE: Depressive symptoms have been associated with myocardial ischemia induced by mental (MSIMI) and exercise (ESIMI) stress in clinically stable ischemic heart disease (IHD) patients, but the association between positive emotions and inducible ischemia is less well characterized. The objective of this study was to examine the associations between ratings of well-being and stress-induced ischemia. METHODS: Subjects were adult patients with documented IHD underwent mental and exercise stress testing for the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) trial...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28079706/ibuprofen-before-exercise-does-not-prevent-cortical-bone-adaptations-to-training
#14
Vanessa D Sherk, R Dana Carpenter, Erin D Giles, Janine A Higgins, Robera M Oljira, Ginger C Johnson, Samuel Mills, Paul S MacLean
: Using a nonsteroidal anti-inflammatory drug (NSAID) before a single bout of mechanical loading can reduce bone formation response. It is unknown whether this translates to an attenuation of bone strength and structural adaptations to exercise training. PURPOSE: To determine whether NSAID use before exercise prevents increases in bone structure and strength in response to weight-bearing exercise. METHODS: Adult female Wistar rats (n=43) were randomized to Ibuprofen (IBU) or Vehicle (VEH) and Exercise (EX) or Sedentary (SED) groups in a 2x2 (drug, activity) ANCOVA design with body weight as the covariate, and data are reported as mean±SE...
January 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28011667/echocardiographic-assessment-of-pulmonary-artery-systolic-pressure-following-treadmill-stress-testing
#15
Arshad A Khan, Mohammad Al-Omary, Ian Renner, Ehtesham Ul Haque, Avedis Ekmejian, Mumtaz Hussain, Laurent Quiqueree, Nicholas J Collins, Stuart Turner
AIMS: The use of treadmill stress echocardiography (SE) for the diagnosis of nascent pulmonary hypertension (PH) has been hampered by a lack of well-defined, post-exercise pulmonary artery systolic pressure (PASP) values across representative age groups in a normal cohort. METHODS AND RESULTS: Five hundred and eleven subjects (mean age: 53 ±14, 68% female) with normal resting PASP were included in the study. All participants performed treadmill exercise using the Bruce protocol to a high level of perceived exertion...
December 23, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28002271/reproducibility-and-reliability-of-optical-coherence-tomography-angiography-for-foveal-avascular-zone-evaluation-and-measurement-in-different-settings
#16
Carlo La Spina, Adriano Carnevali, Alessandro Marchese, Giuseppe Querques, Francesco Bandello
PURPOSE: Optical coherence tomography angiography (OCTA) allows delineating the foveal avascular zone (FAZ) easily and noninvasively. The present study aims to test reproducibility and reliability of FAZ evaluation by means of OCTA in different settings. METHODS: Twenty-four eyes of 24 normal subjects were investigated using AngioVue OCTA Imaging System. A series of OCTA acquisitions were taken both in basal and in different experimental settings after vasoactive stimuli...
December 20, 2016: Retina
https://www.readbyqxmd.com/read/27981192/forced-treadmill-exercise-can-induce-stress-and-increase-neuronal-damage-in-a-mouse-model-of-global-cerebral-ischemia
#17
Martina Svensson, Philip Rosvall, Antonio Boza-Serrano, Emelie Andersson, Jan Lexell, Tomas Deierborg
Physical exercise is known to be a beneficial factor by increasing the cellular stress tolerance. In ischemic stroke, physical exercise is suggested to both limit the brain injury and facilitate behavioral recovery. In this study we investigated the effect of physical exercise on brain damage following global cerebral ischemia in mice. We aimed to study the effects of 4.5 weeks of forced treadmill running prior to ischemia on neuronal damage, neuroinflammation and its effect on general stress by measuring corticosterone in feces...
December 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27930685/exercise-training-prevents-cardiovascular-derangements-induced-by-fructose-overload-in-developing-rats
#18
Daniela Farah, Jonas Nunes, Michelle Sartori, Danielle da Silva Dias, Raquel Sirvente, Maikon B Silva, Patrícia Fiorino, Mariana Morris, Susana Llesuy, Vera Farah, Maria-Cláudia Irigoyen, Kátia De Angelis
The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning...
2016: PloS One
https://www.readbyqxmd.com/read/27918079/high-intensity-treadmill-running-impairs-cognitive-behavior-and-hippocampal-synaptic-plasticity-of-rats-via-activation-of-inflammatory-response
#19
Li-Na Sun, Xiao-Long Li, Fei Wang, Jun Zhang, Dan-Dan Wang, Li Yuan, Mei-Na Wu, Zhao-Jun Wang, Jin-Shun Qi
Although appropriate exercise is beneficial for enhancing brain functions, high-intensity exercise (HIE)-induced cognitive dysfunction is causing more and more concerns nowadays. In the present study, we observed the effects of high-intensity treadmill running on the spatial learning of the adult Sprague Dawley male rats in Y-maze (n = 16 per group), and investigated its possible electrophysiological and molecular mechanisms by examining in vivo hippocampal long-term potentiation (LTP), central inflammatory responses, and JNK/p38/ERK signal pathway...
December 5, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27915207/fixed-distance-walk-tests-at-comfortable-and-fast-speed-potential-tools-for-the-functional-assessment-of-coronary-patients
#20
Marie-Doriane Morard, Delphine Besson, Davy Laroche, Alexandre Naaïm, Vincent Gremeaux, Jean-Marie Casillas
OBJECTIVES: There is ambiguity concerning the walk tests available for functional assessment of coronary patients, particularly for the walking speed. This study explores the psychometric properties of two walking tests, based on fixed-distance tests, at comfortable and fast velocity, in stabilized patients at the end of a cardiac rehabilitation program. METHODS: At a three-day interval 58 coronary patients (mean age of 64.85±6.03 years, 50 men) performed three walk tests, the first two at a comfortable speed in a random order (6-minute walk test - 6MWT - and 400-metre comfortable walk test - 400mCWT) and the third at a brisk speed (200-metre fast walk test - 200mFWT)...
November 30, 2016: Annals of Physical and Rehabilitation Medicine
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