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choroidal neovascularization

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https://www.readbyqxmd.com/read/28641290/long-term-follow-up-of-choroidal-neovascularization-due-to-angioid-streaks-with-pro-re-nata-intravitreal-anti-vegf-treatment
#1
Giovanni Giacomelli, Lucia Finocchio, Ilaria Biagini, Andrea Sodi, Vittoria Murro, Ugo Introini, Monica Varano, Francesco Bandello, Ugo Menchini
PURPOSE: To evaluate the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) drugs with a pro re nata (PRN) regimen for the treatment of choroidal neovascularization (CNV) secondary to angioid streaks (AS). METHODS: This is a retrospective, multicenter, noncomparative case series of consecutive AS eyes affected by treatment-naïve CNV. A complete ophthalmologic examination was performed every 30-45 days after the loading phase, including fluorescein angiography and/or optical coherence tomography...
June 23, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28622313/optical-coherence-tomography-analysis-of-evolution-of-bruch-s-membrane-features-in-angioid-streaks
#2
A Marchese, M Parravano, A Rabiolo, A Carnevali, E Corbelli, M V Cicinelli, M Battaglia Parodi, L Querques, F Bandello, G Querques
PurposeTo describe optical coherence tomography (OCT) features in the Bruch's membrane (BM) of eyes with angioid streaks (AS) and evaluate their evolution over the follow-up.Patients and methodsPatients with AS presenting between March 2016 and September 2016 at two tertiary referral centers were consecutively recruited in this study. Eligibility criteria included prior spectral domain (SD)-OCT images, taken at least 3 months before at the same referral center, with automated eye tracking and image alignment modules...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28613359/octa-imaging-of-choroidal-neovascular-membrane-secondary-to-toxoplasma-retinochoroiditis
#3
Fatih Mehmet Türkcü, Alparslan Şahin, Harun Yüksel, Muhammed Şahin, Ümit Karaalp
Two patients (a 37-year-old man and a 28-year-old woman) who had choroidal neovascular membrane (CNVM) secondary to inactive toxoplasma retinochoroiditis scarring were evaluated. Multimodal imaging including fluorescein angiography, optical coherence tomography (OCT), and OCT angiography (OCTA) was used. CNVM secondary to inactive toxoplasma retinochoroiditis scarring was detected. Representative images of CNVM were demonstrated in the outer retinal layer and choriocapillary layer on OCTA. OCTA, a relatively new technique, is useful in the diagnosis of the CNVMs secondary to retinochoroiditis...
June 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28606070/efficacy-and-safety-of-conbercept-as-a-primary-treatment-for-choroidal-neovascularization-secondary-to-punctate-inner-choroidopathy
#4
Yuting Peng, Xiongze Zhang, Lan Mi, Bing Liu, Chengguo Zuo, Miaoling Li, Feng Wen
BACKGROUND: To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. METHODS: This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with naive subfoveal or juxtafoveal choroidal neovascularization secondary to punctuate inner choroidopathy that were treated with intravitreal conbercept injections...
June 12, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28590964/overview-of-the-complications-of-high-myopia
#5
Yasushi Ikuno
High myopia is very common and one of the major causes of social blindness, especially in East Asian countries. It is characterized by axial length elongation, and induces various specific complications, including cataract formation, retinal detachment from peripheral retinal tears, myopic foveoschisis, macular hole with or without retinal detachment, peripapillary deformation, dome-shaped macula, choroidal/scleral thinning, myopic choroidal neovascularization, and glaucoma. This article will review these complications and discuss the current concepts relating to these complications and their treatments...
January 24, 2017: Retina
https://www.readbyqxmd.com/read/28590318/five-year-outcomes-of-intravitreal-injection-of-ranibizumab-for-the-treatment-of-myopic-choroidal-neovascularization
#6
Tsung-Tien Wu, Ya-Hsin Kung
PURPOSE: To evaluate the 5-year outcomes, efficacy, and safety of intravitreal ranibizumab injections for the treatment of myopic choroidal neovascularization. METHODS: The medical records of 18 consecutive eyes of 14 patients who received intravitreal injections of ranibizumab for myopic choroidal neovascularization with a follow-up of 5 years were retrospectively reviewed. Outcomes included best-corrected visual acuity, total number of treatments, and complications...
January 11, 2017: Retina
https://www.readbyqxmd.com/read/28590317/neovascularization-secondary-to-high-myopia-imaged-by-optical-coherence-tomography-angiography
#7
Elsa Bruyère, Alexandra Miere, Salomon Yves Cohen, David Martiano, Anne Sikorav, Andrada Popeanga, Oudy Semoun, Giuseppe Querques, Eric H Souied
PURPOSE: To describe the optical coherence tomography angiography (OCTA) characteristics of active myopic choroidal neovascularization (CNV) and to compare its sensitivity versus fluorescein angiography and spectral-domain optical coherence tomography. METHODS: Consecutive highly myopic patients complicated with active myopic CNV were prospectively included. The OCTA features were analyzed and correlated with the findings of conventional imaging (spectral-domain optical coherence tomography and fluorescein angiography)...
January 11, 2017: Retina
https://www.readbyqxmd.com/read/28590316/recurrence-of-choroidal-neovascularization-lesion-activity-after-aflibercept-treatment-for-age-related-macular-degeneration
#8
Tomotaka Wakazono, Kenji Yamashiro, Akio Oishi, Sotaro Ooto, Hiroshi Tamura, Yumiko Akagi-Kurashige, Masayuki Hata, Ayako Takahashi, Akitaka Tsujikawa, Nagahisa Yoshimura
PURPOSE: To examine the recurrence rate of choroidal neovascularization (CNV) lesion activity in age-related macular degeneration (AMD) and associated factors after 1-year aflibercept treatment. METHODS: Age-related macular degeneration eyes with 1-year aflibercept fixed-regimen treatment and a follow-up period of at least 18 months from the initial aflibercept injection for treatment-naive exudative AMD were retrospectively evaluated. The recurrence rate was examined...
January 11, 2017: Retina
https://www.readbyqxmd.com/read/28584193/let-7-contributes-to-diabetic-retinopathy-but-represses-pathological-ocular-angiogenesis
#9
Qinbo Zhou, Robert J A Frost, Chastain Anderson, Fangkun Zhao, Jing Ma, Bo Yu, Shusheng Wang
The in vivo function of microRNAs (miRNAs or miRs) in diabetic retinopathy (DR) and age-related macular degeneration (AMD) remains unclear. Here we report that let-7 family members are expressed in retinal and choroidal endothelial cells (EC). In ECs, overexpression of let-7 by adenovirus represses EC proliferation, migration, and networking in vitro, while inhibition of the let-7 family with a locked nucleic acid (LNA)-anti-miR has the opposite effect. Mechanistically, silencing of the let-7 target gene HMGA2 mimics the phenotype of let-7 overexpression in ECs...
June 5, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28583400/focal-choroidal-excavaction-associated-with-idiopathic-choroidal-neovascularization
#10
J L Sánchez-Vicente, T Rueda-Rueda, A C Martínez-Borrego, A Moruno-Rodríguez, F E Molina-Socola, M Contreras-Díaz, A Medina-Tapia, A Muñoz-Morales, F López-Herrero
CASE REPORT: The case is presented of a 45 year-old man with a focal choroidal excavation associated with choroidal neovascularisation not included in the area of excavation. Clinical features were analysed using retinography, fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography. The patient was treated with 3 intravitreal injections of bevacizumab, with a good response. DISCUSSION: Focal choroidal excavation can be associated with choroidal neovascularization not included in the area of excavation...
June 2, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28582276/biomarkers-of-neovascular-activity-in-age-related-macular-degeneration-using-oct-angiography
#11
Mayss Al-Sheikh, Nicholas A Iafe, Nopasak Phasukkijwatana, SriniVas R Sadda, David Sarraf
PURPOSE: To study the qualitative and quantitative features of choroidal neovascular (NV) membranes in age-related macular degeneration using optical coherence tomography angiography in patients with active and quiescent NV lesions before and after treatment with anti-vascular endothelial growth factor. METHODS: Macular optical coherence tomography angiography images were obtained using RTVue XR Avanti with AngioVue. Morphologic features and quantitative measurements of the NV lesion were analyzed using en face projection images...
May 2, 2017: Retina
https://www.readbyqxmd.com/read/28579550/the-application-of-optical-coherence-tomography-angiography-in-retinal-diseases
#12
REVIEW
Kumar Sambhav, Sandeep Grover, K V Chalam
Optical coherence tomography angiography (OCTA) is a new, non-invasive imaging technique that generates real time volumetric data of chorioretinal vasculature and its flow pattern. With the advent of high-speed optical coherence tomography, established en-face chorioretinal segmentation, and efficient algorithms, OCTA generate images that resembles an angiogram. The principle of OCTA involves determining the change in backscattering between consecutive B-scans and then attributing the differences to the flow of erythrocytes through retinal blood vessels...
June 1, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28579549/the-use-of-microperimetry-in-assessing-visual-function-in-age-related-macular-degeneration
#13
REVIEW
Nicola K Cassels, John M Wild, Tom H Margrain, Victor Chong, Jennifer H Acton
Microperimetry is a novel technique for assessing visual function and appears particularly suitable for age-related macular degeneration (AMD). Compared to standard automated perimetry (SAP), microperimetry offers several unique features. It simultaneously images the fundus, incorporates an eye tracking system to correct the stimulus location for fixation loss, and identifies any preferred retinal loci. A systematic review of microperimetry in the assessment of visual function in AMD identified 680 articles...
June 1, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28577175/multi-level-deep-supervised-networks-for-retinal-vessel-segmentation
#14
Juan Mo, Lei Zhang
PURPOSE: Changes in the appearance of retinal blood vessels are an important indicator for various ophthalmologic and cardiovascular diseases, including diabetes, hypertension, arteriosclerosis, and choroidal neovascularization. Vessel segmentation from retinal images is very challenging because of low blood vessel contrast, intricate vessel topology, and the presence of pathologies such as microaneurysms and hemorrhages. To overcome these challenges, we propose a neural network-based method for vessel segmentation...
June 2, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28574419/effect-of-intravitreal-ranibizumab-on-ganglion-cell-complex-and-peripapillary-retinal-nerve-fiber-layer-in-neovascular-age-related-macular-degeneration-using-spectral-domain-optical-coherence-tomography
#15
Ilaria Zucchiatti, Maria V Cicinelli, Maurizio Battaglia Parodi, Luisa Pierro, Marco Gagliardi, Agostino Accardo, Francesco Bandello
PURPOSE: To analyze the changes in ganglion cell complex and peripapillary retinal nerve fiber layer thickness, in central macular thickness and choroidal thickness on spectral domain optical coherence tomography in patients with neovascular age-related macular degeneration treated with intravitreal ranibizumab injections. METHODS: All consecutive patients with untreated neovascular age-related macular degeneration received loading phase of three monthly intravitreal ranibizumab, followed by retreatments on a pro re nata protocol for 12 months...
July 2017: Retina
https://www.readbyqxmd.com/read/28574138/detection-of-nonexudative-choroidal-neovascularization-secondary-to-angioid-streaks-using-optical-coherence-tomography-angiography
#16
Konstantinos D Andreanos, Tryfon Rotsos, Chryssanthi Koutsandrea, Georgios D Kymionis, Ilias Georgalas, Ioannis D Ladas
PURPOSE: To present a case of nonexudative choroidal neovascularization secondary to angioid streaks in a patient with pseudoxanthoma elasticum. The lesion was monitored over an 8-month period with the use of optical coherence tomography angiography. METHODS: Case report. RESULTS: The neovascular tissue area increased by 0.160 mm2 over a period of 8 months without any sign of exudation seen on optical coherence tomography or fluorescein angiography...
May 29, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28570624/macular-bruch-s-membrane-defect-and-dome-shaped-macula-in-high-myopia
#17
Yuxin Fang, Jost B Jonas, Tae Yokoi, Kejia Cao, Kosei Shinohara, Kyoko Ohno-Matsui
PURPOSE: To examine an association between macular Bruch's membrane defects (MBMD) and a dome-shaped appearance of the macula (DSM). DESIGN: Retrospective, observational case series study. METHODS: The study included highly myopic individuals who were consecutively examined between May 2014 and December 2015. The patients underwent swept-source optical coherence tomography (OCT) for visualization of DSM and MBMDs defined as Bruch´s membrane defects located at a distance of maximal 1500 μm from the foveola...
2017: PloS One
https://www.readbyqxmd.com/read/28570484/optical-coherence-tomography-angiography-features-of-choroidal-neovascularization-associated-with-choroidal-nevus
#18
Marco Pellegrini, Federico Corvi, Emil A T Say, Carol L Shields, Giovanni Staurenghi
PURPOSE: To describe the imaging features of choroidal neovascularization (CNV) associated with choroidal nevus using optical coherence tomography angiography (OCT-A) imaging. METHODS: Retrospective observational case series. Patients with CNV secondary to choroidal nevus underwent full imaging examination including fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain OCT, and OCT-A. The OCT-A features were analyzed and correlated with conventional angiography findings and spectral domain OCT...
May 29, 2017: Retina
https://www.readbyqxmd.com/read/28566982/successful-management-of-choroidal-neovascular-membrane-secondary-to-choroidal-osteoma-with-intravitreal-bevacizumab
#19
Brijesh Takkar, Shorya Vardhan Azad, Anil Babanrao Gangwe
No abstract text is available yet for this article.
April 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28560651/bilateral-choroidal-neovascularization-associated-with-gyrate-atrophy-managed-with-intravitreal-bevacizumab
#20
Merve Inanc, Kemal Tekin, Mehmet Yasin Teke
PURPOSE: To report a case with gyrate atrophy (GA) complicated by bilateral choroidal neovascularization (CNV) treated with intravitreal bevacizumab. CASE PRESENTATION: A 20-year-old man presented with a complaint of sudden visual decrease in his both eyes. Best-corrected visual acuity (BCVA) was 20/400 and 20/500, with a spherical refractive error of -2.00 and -1.75 D, in the right and left eyes, respectively. Dilated fundus examination revealed multiple bilateral, sharply defined chorioretinal atrophy areas in the midperipheral and peripheral zone with the suspicion of CNV in both eyes...
May 30, 2017: International Ophthalmology
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