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choroidal neovascularization

Peter L Nesper, Brian T Soetikno, Alison D Treister, Amani A Fawzi
Purpose: To explore whether quantitative three-dimensional (3D) analysis of choroidal neovascularization (CNV) using projection-resolved optical coherence tomography angiography (PR-OCTA) is associated with treatment response in neovascular age-related macular degeneration (nAMD). Methods: Retrospective, cross-sectional study of 51 eyes of 49 patients undergoing individualized anti-VEGF therapy for nAMD. Patients were classified as "good" or "poor" responders, requiring injections at less or more frequently than 6-week intervals, respectively...
April 1, 2018: Investigative Ophthalmology & Visual Science
Jia-Xing Sun, Tian-Fang Chang, Man-Hong Li, Li-Juan Sun, Xian-Chun Yan, Zi-Yan Yang, Yuan Liu, Wen-Qin Xu, Yang Lv, Jing-Bo Su, Liang Liang, Hua Han, Guo-Rui Dou, Yu-Sheng Wang
Ocular neovascularization is a comprehensive process involved in retinal vascular development and several blinding diseases such as age-related macular degeneration and retinopathy of prematurity, with vascular endothelial growth factor (VEGF) regarded as the master regulator. However, the qualified effect of anti-VEGF therapy reveals that the underlying mechanisms are still not clearly identified. To initialize angiogenesis, endothelial cells undergo a phenotype switching to generate highly migratory and invasive cells...
April 19, 2018: Angiogenesis
Guang-Hui He, Wei Zhang, Ying-Xue Ma, Jing Yang, Li Chen, Jian Song, Song Chen
AIM: To observe the effect of exosomes derived from human umbilical cord blood mesenchymal stem cells (hUCMSCs) on the expression of vascular endothelial growth factor-A (VEGF-A) in blue light injured human retinal pigment epithelial (RPE) cells and laser-induced choroidal neovascularization (CNV) in rats. METHODS: Exosomes were isolated from hUCMSCs and characterized by transmission electron microscope and Western blot. MSCs-derived exosomes were cultured with RPE cells exposed to blue light...
2018: International Journal of Ophthalmology
Chao Jiang, Ping Xie, Ruxu Sun, Xiantao Sun, Guohua Liu, Sijia Ding, Meidong Zhu, Biao Yan, Qinghuai Liu, Xue Chen, Chen Zhao
Dedifferentiation of retinal pigment epithelium (RPE) cells and choroidal neovascularization (CNV) contributes to the pathogenesis of age-related macular degeneration (AMD). MicroRNAs (miRNAs) have crucial roles in AMD onset and progression. We thus aim to investigate the effects of miRNAs on RPE dedifferentiation and endothelium cell (EC) behavior, and analyze its downstream pathways. We have previously identified miR-302d-3p as the most downregulated miRNA signature along with RPE differentiation. Herein, in vitro study supported that miR-302d-3p induces RPE dedifferentiation typified by reduction of RPE characteristic markers, interrupts its phagocytosis, and promotes its migration, proliferation, and cell-cycle progression...
April 18, 2018: Cell Death & Disease
Xiaochun Yang, Jianbiao Xu, Jianhui Yang, Yikun Zhou, Yan Mei, Tonghua Yang, Yangmo Zhang
RATIONALE: Characteristic signs of leukemic retinopathy include bilateral intra-retinal hemorrhage, white-centred hemorrhage, macular hemorrhage and cotton-wool spots. Capillary closure, retinal microaneurysms and neovascularization following massive fundus hemorrhage could be involved in few of the above instances. However, single choroidal neovascularization (CNV) in macular has not been observed in acute myelocytic leukemia (AML). PATIENT CONCERNS: A 22-year-old woman presented with a 7-day history of vision decline in the right eye (OD)...
April 2018: Medicine (Baltimore)
Robert B Garoon, J William Harbour
The authors report a case of a congenital hypertrophy of the retinal pigment epithelium (CHRPE) associated with choroidal neovascularization (CNV) causing symptomatic vision loss. Two intravitreal injections of bevacizumab (Avastin; Genentech, South San Francisco, CA) 4 weeks apart resolved the fluid and improved the visual acuity. This case demonstrates that CHRPE can rarely be complicated by CNV, which may respond to intravitreal bevacizumab therapy. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:276-277...
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Paolo Lanzetta, Alan F Cruess, Salomon Y Cohen, Jason S Slakter, Todd Katz, Olaf Sowade, Oliver Zeitz, Christiane Ahlers, Paul Mitchell
PURPOSE: Identify predictors for response to anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular (wet) age-related macular degeneration (nAMD). METHODS: Retrospective, post hoc analysis of VIEW 1/2. Patients were randomized 1:1:1:1 to 0.5 mg intravitreal aflibercept (IVT-AFL) injection every 4 weeks (0.5q4); 2 mg IVT-AFL every 4 weeks (2q4); 2 mg IVT-AFL every 8 weeks (2q8) after an initial three injections at weeks 0, 4 and 8 or 0...
April 16, 2018: Acta Ophthalmologica
Sara Risseeuw, Jeannette Ossewaarde-van Norel, Caroline C W Klaver, Johanna M Colijn, Saskia M Imhof, Redmer van Leeuwen
PURPOSE: To assess the age-specific proportion of visual impairment in patients with pseudoxanthoma elasticum (PXE) and to compare this with foveal abnormality and similar data of late age-related macular degeneration patients. METHODS: Cross-sectional data of 195 patients with PXE were reviewed, including best-corrected visual acuity and imaging. The World Health Organisation criteria were used to categorize bilateral visual impairment. These results were compared with similar data of 131 patients with late age-related macular degeneration from the Rotterdam study...
April 12, 2018: Retina
T Y Alvin Liu, Alice Yang Zhang, Adam Wenick
A 37-year-old Caucasian woman presented with acute decrease in central vision in her right eye and was found to have subfoveal choroidal neovascularization (CNV) due to presumed ocular histoplasmosis syndrome (POHS). Her visual acuity improved from 20/70 to 20/20 at her 6-month follow-up, after 3 consecutive monthly intravitreal bevacizumab injections were initiated at her first visit. Although no CNV activity was seen on fluorescein angiography (FA) or spectral-domain optical coherence tomography (SD-OCT) at her 2-month, 4-month, and 6-month follow-up visits, persistent flow in the CNV lesion was detected on optical coherence tomography angiography (OCTA)...
2018: Case Reports in Ophthalmological Medicine
Carlos A Moreira-Neto, Eric M Moult, James G Fujimoto, Nadia K Waheed, Daniela Ferrara
The purpose of this review is to summarize the current knowledge on choriocapillaris loss in advanced age macular degeneration (AMD). Several histopathological studies in animal models and human eyes had showed that the choriocapillaris density decreases with age. However, the role of choriocapillaris loss is still unclear in AMD and its advanced forms, either choroidal neovascularization (CNV) or geographic atrophy (GA). Some authors have hypothesized that choriocapillaris loss might precede overt retinal pigment epithelium atrophy...
2018: Journal of Ophthalmology
Andrea Russo, Nicolò Scaroni, Elena Gambicorti, Raffaele Turano, Francesco Morescalchi, Ciro Costagliola, Francesco Semeraro
Purpose: The aim of this study was to evaluate whether indomethacin eye drops and intravitreal ranibizumab (IVR) injections would provide additional benefit over ranibizumab alone in the treatment of choroidal neovascularization (CNV). Participants and methods: This was a randomized, prospective pilot study of eyes with new-onset CNV. Fifty-eight patients were randomized 1:1 into a ranibizumab monotherapy (RM) group and a ranibizumab plus indomethacin (RI) group...
2018: Clinical Ophthalmology
Rosa Dolz-Marco, Jay P Glover, Orly Gal-Or, Katie M Litts, Jeffrey D Messinger, Yuhua Zhang, Mariano Cozzi, Marco Pellegrini, K Bailey Freund, Giovanni Staurenghi, Christine A Curcio
PURPOSE: To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases. DESIGN: Histologic survey of donor eyes with and without AMD. Clinical case series with multimodal imaging analysis. PARTICIPANTS: Donor eyes (n = 139; 26 with early AMD, 13 with GA, 40 with nAMD, 52 with a healthy macula, and 8 with other or unknown characteristics) and 41 eyes of 28 participants with GA (n = 16), nAMD (n = 8), Stargardt disease (n = 4), cone dystrophy (n = 2), pachychoroid spectrum (n = 6), choroidal hemangioma (n = 1), and healthy eyes (n = 4)...
April 3, 2018: Ophthalmology
Elisabeth Richert, Stefan Koinzer, Jan Tode, Kerstin Schlott, Ralf Brinkmann, Jost Hillenkamp, Alexa Klettner, Johann Roider
Purpose: To investigate the effect of selective retina therapy (SRT) on the release of AMD-relevant cell mediators, such as matrix metalloproteinases (MMPs), VEGF, and pigment epithelium derived factor (PEDF) using different laser spot sizes and densities. Methods: Porcine RPE-choroid explants were treated with a pulsed 532 nm Nd:YAG laser using (1) large spot sizes, (2) small spot sizes with a high-density (hd) treatment, and (3) small spot sizes with a low-density (ld) treatment...
March 1, 2018: Investigative Ophthalmology & Visual Science
Chi Ming Laurence Lau, Yu Yu, Ghodsiehsadat Jahamir, Ying Chau
Antiangiogenic therapeutics, such as corticosteroids, VEGF targeting antibodies and aptamers have been demonstrated effective in controlling retinal and choroidal neovascularization related vision loss. However, to manage the chronic conditions, it requires long term and frequent intravitreal injections of these drugs, resulting in poor patient compliance and suboptimal treatment. In addition, emerging drugs such as tyrosine kinase inhibitors and siRNAs received much expectations, but the late stage clinical trials encountered various obstacles...
April 3, 2018: Advanced Drug Delivery Reviews
Marco Lupidi, Alessio Cerquaglia, Jay Chhablani, Tito Fiore, Sumit Randhir Singh, Felice Cardillo Piccolino, Roberta Corbucci, Florence Coscas, Gabriel Coscas, Carlo Cagini
Optical coherence tomography angiography is one of the biggest advances in ophthalmic imaging. It enables a depth-resolved assessment of the retinal and choroidal blood flow, far exceeding the levels of detail commonly obtained with dye angiographies. One of the first applications of optical coherence tomography angiography was in detecting the presence of choroidal neovascularization in age-related macular degeneration and establishing its position in relation to the retinal pigmented epithelium and Bruch's membrane, and thereby classifying the CNV as type 1, type 2, type 3, or mixed lesions...
April 1, 2018: European Journal of Ophthalmology
Xueting Luo, Shiqi Yang, Jian Liang, Yuanqi Zhai, Mengxi Shen, Junran Sun, Yiji Feng, Xinmin Lu, Hong Zhu, Fenghua Wang, Xiaodong Sun
Subretinal fibrosis results in local destruction of retinal structures and permanent vision loss, representing the end stage of neovascular age-related macular degeneration (AMD). Histological examination of fibrotic specimens from AMD patients has uncovered a wide range of cellular and acellular components. However, their origins and roles in fibrosis remain largely unexplored. Using laser-induced photocoagulation model with Collagen 1α1-GFP reporter mice, we demonstrate by cell-lineage tracing that a subset of pericytes associating with choroidal microvasculature are activated upon injury and infiltrate into subretinal space as significant components of fibrotic lesions...
April 4, 2018: Disease Models & Mechanisms
Rosa Dolz-Marco, Chandrakumar Balaratnasingam, Sarra Gattoussi, Seungjun Ahn, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To analyze the changes in visual acuity and subfoveal choroidal thickness in patients with non-neovascular age-related macular degeneration (AMD) and drusenoid pigment epithelium detachments (PED). DESIGN: Consecutive observational case series. METHODS: Observational retrospective review of eyes diagnosed with drusenoid PED in a single clinical setting. Demographic and clinical data included age, gender, laterality, best corrected visual acuity (BCVA) and subfoveal choroidal thickness measured at baseline, before and after the collapse of the PED, and at the last available follow-up...
April 2, 2018: American Journal of Ophthalmology
Bing Liu, Xiongze Zhang, Lan Mi, Ling Chen, Feng Wen
Purpose: To investigate the relationship between simple hemorrhage (SH) associated with lacquer crack (LC) and myopic choroidal neovascularization (CNV) in high myopia. Methods: A cross-sectional evaluation including best-corrected visual acuity (BCVA), axial length, refractive error, color fundus photography, and spectral domain optical coherence tomography (SD-OCT) was performed in patients diagnosed with high myopia and SH. Fundus fluorescein angiography and indocyanine green angiography were performed if the eye was suspected with CNV...
2018: Journal of Ophthalmology
Lei Feng, Jiang-Hua Hu, Jie Chen, Xin Xie
OBJECTIVE: To evaluate the effect of anti-vascular endothelial growth factor (VEGF) on juxtafoveal choroidal neovascularization (CNV) secondary to multifocal choroiditis (MFC) and wet age-related macular degeneration (AMD). METHODS: In this retrospective, comparative study, 20 unique eyes with CNV were divided into two groups: 10 patients affected by MFC and 10 patients diagnosed with wet AMD. They all received local intravitreal (IVT) injections of ranibizumab, with 6 months of follow-up...
2018: Journal of Zhejiang University. Science. B
Fangkun Zhao, Bei Shi, Ruixin Liu, Wenkai Zhou, Dong Shi, Jinsong Zhang
BACKGROUND: The distribution pattern and knowledge structure of choroidal neovascularization (CNV) was surveyed based on literatures in PubMed. METHODS: Published scientific papers about CNV were retrieved from Jan 1st, 2012 to May 31st, 2017. Extracted MeSH terms were analyzed quantitatively by using Bibliographic Item Co-Occurrence Matrix Builder (BICOMB) and high-frequency MeSH terms were identified. Hierarchical cluster analysis was conducted by SPSS 19.0 according to the MeSH term-source article matrix...
April 3, 2018: BMC Ophthalmology
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