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choroidal neovascularization

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https://www.readbyqxmd.com/read/29454660/development-and-course-of-scars-in-the-comparison-of-age-related-macular-degeneration-treatments-trials
#1
Ebenezer Daniel, Wei Pan, Gui-Shuang Ying, Benjamin J Kim, Juan E Grunwald, Frederick L Ferris, Glenn J Jaffe, Cynthia A Toth, Daniel F Martin, Stuart L Fine, Maureen G Maguire
PURPOSE: To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Multicenter, prospective cohort study. PARTICIPANTS: A total of 1061 subjects in CATT. METHODS: Color photographic and fluorescein angiographic images from baseline and 1, 2, and 5 years were evaluated. Incidence of scar formation was estimated with Kaplan-Meier curves...
February 14, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29450540/endocan-blockade-suppresses-experimental-ocular-neovascularization-in-mice
#2
Ting Su, Yisheng Zhong, Anna M Demetriades, Jikui Shen, Ailing Sui, Yiyun Yao, Yushuo Gao, Yanji Zhu, Xi Shen, Bing Xie
Purpose: Ocular neovascularization (NV) is a pathologic process characterized by the proliferation and infiltration of various types of cells such as RPE, glial, and endothelial cells, which interact with proangiogenic factors and inflammatory cytokines. Endocan is known to be enriched in retinal endothelial tip cells under hypoxia, but the effect of endocan on ocular NV progression is largely unknown. In this study, we investigated the role of endocan in the ocular NV pathologic process and the possible mechanisms involved...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29446046/anti-neovascularization-effects-of-dmbt-in-age-related-macular-degeneration-by-inhibition-of-vegf-secretion-through-ros-dependent-signaling-pathway
#3
Shang Chen, Yue Zhou, Lichun Zhou, Yanhui Guan, Yu Zhang, Xiuzhen Han
Choroidal neovascularization (CNV) is the hallmark of late-staged wet age-related macular degeneration (AMD). Vascular endothelial growth factor (VEGF) is a key component in the development and progression of wet AMD. DMBT, 6,6'-bis(2,3-dimethoxybenzoyl)-α,α-D-trehalose, had been proved that it could suppress tumor angiogenesis and metastasis by inhibiting production of VEGF. But the effects of DMBT on CNV were not known. This study was to investigate effects and mechanisms of DMBT on CNV in vitro and in vivo...
February 14, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29443807/multimodal-imaging-of-angioid-streaks-associated-with-turner-syndrome
#4
Bing Q Chiu, Edmund Tsui, Syed Amal Hussnain, Irene A Barbazetto, R Theodore Smith
PURPOSE: To report multimodal imaging in a novel case of angioid streaks in a patient with Turner syndrome with 10-year follow-up. METHODS: Case report of a patient with Turner syndrome and angioid streaks followed at Bellevue Hospital Eye Clinic from 2007 to 2017. Fundus photography, fluorescein angiography, and optical coherence tomography angiography were obtained. RESULTS: Angioid streaks with choroidal neovascularization were noted in this patient with Turner syndrome without other systemic conditions previously correlated with angioid streaks...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29443356/use-of-optical-coherence-tomography-angiography-in-masqueraders-of-wet-age-related-macular-degeneration-and-choroidal-neovascularization
#5
Sidney Schechet, Seenu M Hariprasad, Asadolah Movahedan, Dimitra Skondra
No abstract text is available yet for this article.
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29443029/in-vivo-multimodal-imaging-and-analysis-of-mouse-laser-induced-choroidal-neovascularization-model
#6
Symantas Ragauskas, Eva Kielczewski, Joseph Vance, Simon Kaja, Giedrius Kalesnykas
Laser-induced choroidal neovascularization (CNV) is a well-established model to mimic the wet form of age-related macular degeneration (AMD). In this protocol, we aim to guide the reader not simply through the technical considerations of generating laser-induced lesions to trigger neovascular processes, but rather focus on the powerful information that can be obtained from multimodal longitudinal in vivo imaging throughout the follow-up period. The laser-induced mouse CNV model was generated by a diode laser administration...
January 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29436399/type-2-choroidal-neovascularisation-in-polypoidal-choroidal-vasculopathy-a-retrospective-case-series
#7
Shuting Liang, Xuan Shi, Philip J Rosenfeld, Xiaoxin Li
BACKGROUND AND OBJECTIVE: To demonstrate the coexistence of polypoidal choroidal vasculopathy (PCV) with type 2 neovascularisation (NV), we used multimodal imaging, including spectral-domain optical coherence tomography angiography (SD-OCTA), to identify both types of lesions in the same eye. STUDY DESIGN: This retrospective case series reviewed patients with PCV diagnosed with indocyanine green angiography (ICGA), fluorescein angiography (FA), SD-OCT and SD-OCTA...
February 7, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29428319/characterization-and-functional-correlation-of-multiple-imaging-modalities-with-focal-choroidal-excavation
#8
Yun-Chen Chen, Yu-Bai Chou, Cheng-Kuan Lin, Chia-Chen Tsai, Tsui-Kang Hsu, Yu-Fan Chang, Hsiao-Ming Chao, Tao-Hsin Tung, Shih-Jen Chen, Jorn-Hon Liu
BACKGROUND: To investigate the clinical manifestations and imaging features of near-infrared autofluorescence (NIA), infrared reflectance (IR), fundus autofluorescence (FAF), indocyanine green angiography (ICGA) and fluorescein angiography (FAG) in the detection of patients with focal choroidal excavation (FCE) identified by cross-sectional spectral-domain optical coherence tomography (SD-OCT). METHODS: This retrospective cross-sectional study included 12 eyes of 10 Taiwanese patients with FCE diagnosed by SD-OCT...
February 7, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29422766/inhibition-of-yap-ameliorates-choroidal-neovascularization-via-inhibiting-endothelial-cell-proliferation
#9
Zhenzhen Yan, Haihong Shi, Rongrong Zhu, Lele Li, Bai Qin, Lihua Kang, Hui Chen, Huaijin Guan
Purpose: Age-related macular degeneration (AMD) is the leading cause of central visual loss among patients over the age of 55 years worldwide. Neovascular-type AMD (nAMD) accounts for approximately 10% of patients with AMD and is characterized by choroidal neovascularization (CNV). The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29411259/intravitreal-aflibercept-for-the-treatment-of-choroidal-neovascularization-associated-with-rubella-retinopathy
#10
Hasan Kiziltoprak, Esat Yetkin, Kemal Tekin, Mustafa Koc, İrfan Akalin, Mehmet Yasin Teke
PURPOSE: To report a case of choroidal neovascularization (CNV) associated with rubella retinopathy (RR) treated with intravitreal aflibercept. CASE PRESENTATION: A 15-year-old girl presented a complaint of visual decrease in her left eye. She had a history of hearing decrease since she was 1 year old in addition to patent ductus arteriosus. On ocular examination, the best corrected visual acuity (BCVA) was 20/20 in the right eye and 20/400 in the left eye. Dilated fundus examinations revealed a classic salt-and-pepper appearance in both eyes and a whitish subretinal lesion with retinal hemorrhages in the left macula...
February 6, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29411171/efficacy-of-treat-and-extend-regimen-with-aflibercept-for-pachychoroid-neovasculopathy-and-type-1-neovascular-age-related-macular-degeneration
#11
Hidetaka Matsumoto, Takashi Hiroe, Masahiro Morimoto, Kensuke Mimura, Arisa Ito, Hideo Akiyama
PURPOSE: To evaluate the efficacy of intravitreal aflibercept therapy using a treat-and-extend regimen on treatment-naïve pachychoroid neovasculopathy (PNV) and Type 1 neovascular age-related macular degeneration (AMD). METHODS: We retrospectively studied 42 eyes with PNV and 60 eyes with Type 1 neovascular AMD. We assessed best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), and total number of injections over 2 years...
February 6, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29409899/a-12-year-study-of-slotted-palladium-103-plaque-radiation-therapy-for-choroidal-melanoma-near-touching-or-surrounding-the-optic-nerve
#12
Abhilasha Maheshwari, Paul T Finger
PURPOSE: To present our 12-year experience with low energy photon, slotted eye plaque radiation therapy. DESIGN: Retrospective interventional case series METHODS: SETTING: The New York Eye Cancer Center. STUDY POPULATION: Fifty-two consecutive patients with uveal melanomas near, touching or surrounding the optic disc. INTERVENTION: Slotted eye plaque radiation therapy. MAIN OUTCOME MEASURES: change in visual acuity, local tumor control, radiation side effects, eye salvage and systemic metastases...
January 31, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29400470/the-discovery-of-n-1-methyl-5-trifluoromethyl-1h-pyrazol-3-yl-5-6-methylamino-methyl-pyrimidin-4-yl-oxy-1h-indole-1-carboxamide-acrizanib-a-vegfr-2-inhibitor-specifically-designed-for-topical-ocular-delivery-as-a-therapy-for-neovascular-age-related-macular
#13
Christopher M Adams, Karen Anderson, Gerald Artman, Jean-Claude Bizec, Rosemarie Cepeda, Jason Elliott, Elizabeth Fassbender, Malay Ghosh, Shawn Hanks, Leo A Hardegger, Vinayak P Hosagrahara, Bruce Jaffee, Keith Jendza, Nan Ji, Leland Johnson, Wendy Lee, Donglei Liu, Fang Liu, Debby Long, Fupeng Ma, Nello Mainolfi, Erik L Meredith, Karl Miranda, Yao Peng, Stephen Poor, James Powers, Yubin Qiu, Chang Rao, Siyuan Shen, Jeremy M Sivak, Catherine Solovay, Peter Tarsa, Amber Woolfenden, Chun Zhang, Yiqin Zhang
A noninvasive topical ocular therapy for the treatment of neovascular or "wet" age-related macular degeneration would provide a patient administered alternative to the current standard of care, which requires physician administered intravitreal injections. This manuscript describes a novel strategy for the use of in vivo models of choroidal neovascularization (CNV) as the primary means of developing SAR related to efficacy from topical administration. Ultimately, this effort led to the discovery of acrizanib (LHA510), a small-molecule VEGFR-2 inhibitor with potency and efficacy in rodent CNV models, limited systemic exposure after topical ocular administration, multiple formulation options, and an acceptable rabbit ocular PK profile...
February 5, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29397245/choroidal-osteoma-with-choroidal-excavation-and-associated-neovascular-membrane-an-oct-angiography-study
#14
R Clemente-Tomás, M Cerdà-Ibáñez, A Gargallo-Benedicto, C Marín-Lambíes, L Manfreda-Domínguez, A M Duch-Samper
CLINICAL CASE: A case is presented of a unilateral choroidal osteoma with choroidal excavation and associated neovascular membrane that was studied using OCT-angiography. The OCT and OCT-angiography revealed an area of choroidal excavation and an active neovascular membrane. Three doses of aflibercept were administered to the patient, which stabilised the neovascularisation. DISCUSSION: OCT-angiography was used to analyse the morphology of the superficial vascular network of the osteoma, as well as to monitor the evolution of the neovascular membrane...
January 31, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29391474/erythropoietin-signaling-increases-choroidal-macrophages-and-cytokine-expression-and-exacerbates-choroidal-neovascularization
#15
Colin A Bretz, Vladimir Divoky, Josef Prchal, Eric Kunz, Aaron B Simmons, Haibo Wang, Mary Elizabeth Hartnett
Erythropoietin (EPO) is recognized for neuroprotective and angiogenic effects and has been associated with aging and neovascular age-related macular degeneration (AMD). We hypothesized that systemic EPO facilitates the development of choroidal neovascularization (CNV). Wild type mice expressed murine EPOR (mWtEPOR) in RPE/choroids at baseline and had significantly increased serum EPO after laser treatment. To test the role of EPO signaling, we used human EPOR knock-in mice with the mWtEPOR gene replaced by either the human EPOR gene (hWtEPOR) or a mutated human EPOR gene (hMtEPOR) in a laser-induced choroidal neovascularization (LCNV) model...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29390361/comparison-of-the-efficacy-of-intravitreal-ranibizumab-for-choroidal-neovascularization-due-to-pathological-myopia-with-and-without-a-dome-shaped-macula
#16
Bincui Cai, Jin Yang, Shuang Li, Linni Wang, Lu Chen, Xiaorong Li, Zhiqing Li
Ranibizumab injection in the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM) with and without a dome-shaped macula (DSM).Prospective observational study.A total of 24 patients (24 eyes) with angiographic evidence of CNV secondary to PM were divided into 2 groups: eyes with a DSM and eyes without DSM. All patients received a baseline intravitreal ranibizumab injection. Additional injections were considered at each follow-up visit. Best-corrected visual acuity (BCVA) and optical coherence tomography were tested monthly through 12 months of follow-up...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29389406/imaging-of-neovascular-membrane-over-a-choroidal-osteoma-by-oct-angiography
#17
Ana Beatriz D Grisolia, Maira de França Martins, Hakan Demirci
No abstract text is available yet for this article.
February 2018: Ophthalmology
https://www.readbyqxmd.com/read/29380768/clinical-features-and-treatment-outcomes-of-vasoproliferative-tumors-in-indian-participants
#18
Jaydeep Avinash Walinjkar, Unnati Shivshankar Sharma, Pukhraj Rishi, Ekta Rishi, Lingam Gopal, Tarun Sharma
PURPOSE: The aim of the study was to describe the clinical features and treatment outcomes of vasoproliferative tumors (VPT) in Indian participants. METHODS: This study design was a retrospective case series in a tertiary eye care center. Case records of patients diagnosed with VPT from 2011 to 2015 were reviewed, and their demographic details, clinical presentation, and treatment outcomes were documented. Baseline and follow-up visual acuity and tumor dimensions were statistically compared by applying paired t-test...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29376143/bevacizumab-injection-in-patients-with-neovascular-age-related-macular-degeneration-increases-angiogenic-biomarkers
#19
Thiago Cabral, Luiz H Lima, Luiz Guilherme M Mello, Júlia Polido, Éverton P Correa, Akiyoshi Oshima, Jimmy Duong, Pedro Serracarbassa, Caio V Regatieri, Vinit B Mahajan, Rubens Belfort
Purpose: To evaluate the expression of 19 angiogenic biomarkers in the aqueous humor before and after intravitreal bevacizumab injection (IVB) in eyes with neovascular age-related macular degeneration (AMD). Design: Prospective, noncomparative, interventional case series. Participants: Twenty-three eyes of 23 treatment-naïve patients with choroidal neovascularization (CNV) secondary to neovascular AMD. Methods: Eyes were diagnosed with CNV secondary to neovascular AMD and were treated with 3 monthly IVBs...
January 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29374796/subfoveal-choroidal-thickness-predicts-macular-atrophy-in-age-related-macular-degeneration-results-from-the-trex-amd-trial
#20
Wenying Fan, Nizar Saleh Abdelfattah, Akihito Uji, Jianqin Lei, Michael Ip, SriniVas R Sadda, Charles C Wykoff
BACKGROUND: Our purpose was to evaluate the relationship between subfoveal choroidal thickness (SCT) and development of macular atrophy (MA) in eyes with age-related macular degeneration (AMD). METHODS: This was a prospective, multicenter study. Sixty participants (120 eyes) in the TREX-AMD trial (NCT01648292) with treatment-naïve neovascular AMD (NVAMD) in at least one eye were included. SCT was measured by certified reading center graders at baseline using spectral domain optical coherence tomography (SDOCT)...
January 27, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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