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choroidal neovascularization

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https://www.readbyqxmd.com/read/28098736/foveal-exudate-and-choroidal-neovascularization-in-atypical-cases-of-multiple-evanescent-white-dot-syndrome
#1
Kevin C Chen, Marcela Marsiglia, Rosa Dolz-Marco, Sarwar Zahid, Sarah Mrejen, Jose S Pulido, Salomon Y Cohen, Benjamin Freilich, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe atypical cases of multiple evanescent white dot syndrome (MEWDS) associated with foveal exudation, increased choroidal thickness, and secondary Type 2 (subretinal) neovascularization. METHODS: Four cases of atypical MEWDS were studied at a retina referral center. Patients underwent evaluation with multimodal retinal imaging, including fluorescein angiography, indocyanine green angiography, spectral-domain and enhanced depth imaging optical coherence tomography (OCT)...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098734/multimodal-fundus-imaging-of-outer-retinal-tubulations-in-choroidal-osteoma-patients
#2
Yi Xuan, Yongjin Zhang, Min Wang, Jinli Guo, Lei Li, Wei Liu, Xiaofeng Ye
PURPOSE: To evaluate the morphological findings of outer retinal tubulations (ORTs) shown on multimodal imaging modalities in patients with choroidal osteoma. METHODS: Nineteen eyes of 17 patients with choroidal osteoma underwent full clinical and imaging assessments. Color fundus photography, spectral-domain optical coherence tomography (OCT), and en face OCT were used to identify and detect the characteristics of ORT structures, including the shape, configuration, location, and distribution in the fundus...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098725/how-vitreomacular-interface-modifies-the-efficacy-of-anti-vegf-therapy-for-myopic-choroidal-neovascularization
#3
Pierluigi Iacono, Maurizio Battaglia Parodi, Lorenzo Iuliano, Francesco Bandello
PURPOSE: To evaluate the efficacy of intravitreal ranibizumab in the treatment of myopic choroidal neovascularization (mCNV) complicated by vitreoretinal interface alterations. METHODS: Thirty-two patients affected by mCNV and concurrent vitreoretinal interface disorders, including macular epiretinal membrane (18 patients), lamellar macular hole (4 patients), full-thickness macular hole (1 patient), broad/focal vitreomacular traction (3 patients), broad/focal vitreomacular adhesion (4 patients), and myopic foveoschisis (2 patients), were enrolled in a prospective study...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28092911/behaviour-of-cd11b-positive-cells-in-an-animal-model-of-laser-induced-choroidal-neovascularisation
#4
Lu Li, Peter Heiduschka, Anne F Alex, Daniel Niekämper, Nicole Eter
BACKGROUND/AIM: Immune cells, e.g. microglial cells of the retina, appear to be involved in pathological processes in neovascular age-related macular degeneration. Therefore, the purpose of this study was to immunohistochemically check the expression of various factors and cytokines by CD11b-positive (CD11b+) immune cells in an animal model of choroidal neovascularisation (CNV). METHODS: We used the animal model of laser-induced CNV in mice. Eyes were isolated at 1, 4, 7, and 14 days after laser treatment...
January 17, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28092343/natural-course-of-patients-discontinuing-treatment-for-age-related-macular-degeneration-and-factors-associated-with-visual-prognosis
#5
Jae Hui Kim, Young Suk Chang, Jong Woo Kim
PURPOSE: To evaluate the 24-month natural course of visual changes in patients discontinuing treatment despite persistent or recurrent fluid and factors predictive of visual prognosis. METHODS: This retrospective, observational study included 35 patients (35 eyes) who initially received anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration (AMD), but discontinued treatment despite persistent or recurrent fluid. The best-corrected visual acuity (BCVA) at treatment discontinuation was determined and compared with the 24-month BCVA, which was then compared between polypoidal choroidal vasculopathy and other neovascular age-related macular degeneration subtypes...
January 13, 2017: Retina
https://www.readbyqxmd.com/read/28088509/choroidal-neovascularization-in-malattia-leventinese-diagnosed-using-optical-coherence-tomography-angiography
#6
Rita Serra, Florence Coscas, Nabil Messaoudi, Mayer Srour, Eric Souied
PURPOSE: To compare Optical Coherence Tomography Angiography (OCT-A) with traditional multimodal imaging in patients with Malattia Leventinese DESIGN: Retrospective case series. METHODS: Eight eyes of four consecutive patients with Malattia Leventinese were retrospectively studied. All patients underwent a complete ophthalmological examination including color fundus photography, fluorescein and indocyanine green angiographies, Spectral Domain Optical Coherence Tomography and Optical Coherence Tomography Angiography...
January 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28079023/incidence-and-growth-of-geographic-atrophy-during-5-years-of-comparison-of-age-related-macular-degeneration-treatments-trials
#7
Juan E Grunwald, Maxwell Pistilli, Ebenezer Daniel, Gui-Shuang Ying, Wei Pan, Glenn J Jaffe, Cynthia A Toth, Stephanie A Hagstrom, Maureen G Maguire, Daniel F Martin
PURPOSE: To estimate the incidence, size, and growth rate of geographic atrophy (GA) during 5 years of follow-up among participants in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort within a clinical trial. PARTICIPANTS: Participants included in CATT. METHODS: A total of 1185 CATT participants were randomly assigned to ranibizumab or bevacizumab treatment and to 3 treatment regimens...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/28062929/epidemiology-treatment-pattern-and-health-care-utilization-of-myopic-choroidal-neovascularization-a-population-based-study
#8
Ming-Chin Yang, Yen-Po Chen, Elise Chia-Hui Tan, Claudia Leteneux, Erin Chang, Carol Hy Chu, Chi-Chun Lai
PURPOSE: To investigate the prevalence and incidence of myopic choroidal neovascularization (CNV) in Taiwan, including the health care utilization and treatment-associated costs. METHODS: A retrospective cohort study using existing data from the Taiwanese National Health Insurance claims database to identify patients who had a diagnosis of myopic CNV recorded from 1 January 2009 to 31 December 2011. The prevalence of myopic CNV was monitored during this period, and the frequency and cost of both treatment visits and monitoring visits were analyzed for 2 years following diagnosis...
January 6, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28060392/intravitreal-aflibercept-for-neovascular-polypoidal-choroidal-vasculopathy-in-a-predominantly-non-asian-population-rival-results
#9
Amina Farooq, Heather Frazier, William B Marcus, Chelsea Fechter, Harinderjit Singh, Dennis M Marcus
BACKGROUND AND OBJECTIVE: To evaluate safety and efficacy of intravitreal aflibercept (Eylea; Regeneron, Tarrytown, NY) injection (IAI) for the treatment of neovascular polypoidal choroidal vasculopathy (PCV) in a predominantly non-Asian population. PATIENTS AND METHODS: This was an open-label, prospective, unmasked, nonrandomized clinical trial. Twenty eyes with neovascular PCV received monthly 2.0 mg IAI for 3 months followed by mandatory IAI every 2 months for 12 months...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060148/short-term-safety-of-2-mg-intravitreal-ziv-aflibercept
#10
Jay Chhablani, Chintan Jethalal Dedhia, Hari K Peguda, Michael Stewart
PURPOSE: To evaluate the safety of single intravitreal 2 mg ziv-aflibercept (0.08 mL) injections for the treatment of choroidal neovascular membranes (CNVM). METHODS: Eyes with choroidal neovascular membranes because of several conditions each received single intravitreal injections of 2 mg ziv-aflibercept (0.08 mL). Comprehensive ophthalmic examinations and detailed systemic evaluations were performed at baseline and Days 1, 7, and 30 after injections. Standard electroretinography was performed at baseline and Day 30...
January 2, 2017: Retina
https://www.readbyqxmd.com/read/28058667/evaluation-of-high-risk-features-of-primary-enucleation-of-patients-with-retinoblastoma-in-a-tertiary-center-of-a-developing-country-in-the-era-of-intra-arterial-chemotherapy
#11
Funda Dikkaya, Ahmet Murat Sarıcı, Firuze Erbek, Tiraje Celkan, Mehmet Serhat Mangan, Övgü Aydın, Cuyan Demirkesen, Halit Pazarlı
PURPOSE: To evaluate the frequency of high-risk histopathologic factors in Turkish children enucleated for retinoblastoma and to analyze the association between growth pattern, rosetta formation, tumor thickness, presence of necrosis, calcification, neovascularization, rate of mitosis, and high-risk histopathologic factors. METHODS: Pathology reports of 59 eyes who had received enucleation for retinoblastoma were reviewed retrospectively. The histopathologic data included presence of choroidal invasion, optic nerve invasion, scleral extension, tumor thickness, presence of necrosis, calcification, neovascularization, rosetta formation and lymphocyte infiltration, rate of mitosis, and growth pattern...
January 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28058163/clinical-features-and-course-of-patients-with-peripheral-exudative-hemorrhagic-chorioretinopathy
#12
Zafer Cebeci, Yasemin Dere, Şerife Bayraktar, Samuray Tuncer, Nur Kır
OBJECTIVES: To evaluate the clinical characteristics of patients who were followed in our clinic with the diagnosis of peripheral exudative hemorrhagic chorioretinopathy (PEHC). MATERIALS AND METHODS: Medical records of 12 patients who were diagnosed with PEHC in İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology between July 2006 and June 2014 were reviewed retrospectively. RESULTS: This study included 21 eyes of 12 patients...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057649/choroid-morphometric-analysis-in-non-neovascular-age-related-macular-degeneration-by-means-of-optical-coherence-tomography-angiography
#13
Maria Vittoria Cicinelli, Alessandro Rabiolo, Alessandro Marchese, Luigi de Vitis, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
AIMS: To describe the vascular changes in patients affected by non-neovascular age-related macular degeneration (AMD), featuring reticular pseudodrusen (RPD), drusen, or both RPD and drusen by means of optical coherence tomography angiography (OCT-A). METHODS: Cross-sectional observational case series. Patients with non-neovascular AMD presenting at the Medical Retina Service of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28053502/neovascular-age-related-macular-degeneration-without-drusen-in-the-fellow-eye-clinical-spectrum-and-therapeutic-outcome
#14
Wing H Chung, Elon H C van Dijk, Danial Mohabati, Greet Dijkman, Suzanne Yzer, Eiko K de Jong, Sascha Fauser, Reinier O Schlingemann, Carel B Hoyng, Camiel J F Boon
PURPOSE: To investigate the clinical characteristics and therapeutic outcome of patients with neovascular age-related macular degeneration (nAMD) in 1 eye, without drusen in the fellow eye. PATIENTS AND METHODS: Medical records of 381 patients were analyzed to identify the cases. The main outcomes included Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) and change in central retinal thickness (CRT). These parameters were reviewed at baseline, first follow-up visit, and after 6, 12, and 24 months...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28050329/focal-choroidal-excavation
#15
Zafer Cebeci, Şerife Bayraktar, Merih Oray, Nur Kır
Focal choroidal excavation is a choroidal pit that can be detected by optical coherence tomography. Central serous chorioretinopathy, choroidal neovascularization and polypoidal choroidal vasculopathy are pathologies associated with focal choroidal excavation. In this article, we present the follow-up and treatment outcomes of three eyes of two patients with focal choroidal excavation.
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28039766/proangiogenic-characteristics-of-activated-macrophages-from-patients-with-age-related-macular-degeneration
#16
Shira Hagbi-Levi, Michelle Grunin, Tareq Jaouni, Liran Tiosano, Batya Rinsky, Sarah Elbaz-Hayoun, Amnon Peled, Itay Chowers
Macrophages were previously implicated in the pathogenesis of neovascular age-related macular degeneration (nvAMD). It is unclear if a specific macrophage phenotype is associated with nvAMD, and if macrophages from nvAMD patients are more pathogenic as compared with controls. To address these issues, we evaluated macrophages derived from peripheral blood monocytes of nvAMD patients and age-matched controls. Macrophages were assessed in terms of their expression profile and of their angiogenic potential in the choroid sprouting assay and the rat model of laser-induced choroidal neovascularization...
December 10, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/28033280/stereotactic-radiotherapy-in-neovascular-age-related-macular-degeneration-real-life-efficacy-and-morphological-evaluation-of-the-outer-retina-choroid-complex
#17
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Corinna Melchert, Dirk Rades, Salvatore Grisanti
Stereotactic radiotherapy (SRT) is a new approach to treat neovascular age-related macular degeneration (nAMD). The INTREPID trial suggested that SRT could reduce the frequency of regular intravitreal injections (IVIs) with antivascular endothelial growth factor drugs, which are necessary to control disease activity. However, the efficacy of SRT in nAMD and resulting morphological changes have not been validated under real-life circumstances, an issue, which we would like to address in this retrospective analysis...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28033235/factors-influencing-visual-acuity-in-patients-receiving-anti-vascular-endothelial-growth-factor-for-myopic-choroidal-neovascularization
#18
Pierluigi Iacono, Maurizio Battaglia Parodi, Federico Selvi, Maria Cristina Parravano, Adele Chiaravalloti, Monica Varano, Francesco Bandello
PURPOSE: To identify the prognostic variables relative to myopic choroidal neovascularization (CNV) treated with intravitreal ranibizumab/bevacizumab. METHODS: Forty-eight patients with myopic CNV were enrolled in a prospective, interventional, non-randomized 12-month study. Intravitreal ranibizumab/bevacizumab was administered in a pro-re-nata regimen and re-treatment was performed in the presence of angiographic leakage, intraretinal/subretinal fluid on optical coherence tomography, new hemorrhages, five-letter decrease and increased metamorphosia...
December 28, 2016: Retina
https://www.readbyqxmd.com/read/28031699/long-term-follow-up-of-patients-with-choroidal-neovascularization-due-to-angioid-streaks
#19
Maria Guadalupe Martinez-Serrano, Abelardo Rodriguez-Reyes, Jose Luis Guerrero-Naranjo, Guillermo Salcedo-Villanueva, Jans Fromow-Guerra, Gerardo García-Aguirre, Virgilio Morales-Canton, Raul Velez-Montoya
BACKGROUND: The following case series describes the long-term anatomical and functional outcome of a group of seven patients with choroidal neovascularization (CNV), secondary to angioid streaks (AS), who were treated with antiangiogenic drugs in a pro re nata (PRN) regimen. After the 4-year mark, visual acuity tends to return to pretreatment level. Treatment delays and lack of awareness and self-referral by the patients are believed to be the cause of the PRN regimen failure. PURPOSE: To assess the long-term outcomes (>4 years) of patients with CNV due to AS treated with a PRN regimen of antiangiogenic...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28009412/optical-coherence-tomography-angiography-of-polypoidal-neovascularization-associated-with-choroidal-nevus
#20
Maria Vittoria Cicinelli, Lorenzo Iuliano, Alessandro Rabiolo, Alessandro Marchese, Giuseppe Querques, Francesco Bandello
PURPOSE: To report a case of juxtapapillary polypoidal choroidal neovascularization (PCNV) associated with choroidal nevus investigated by means of optical coherence tomography angiography (OCT-A). METHODS: Case report. RESULTS: A 72-year-old woman presented with visual loss and metamorphopsia in her left eye for 5 days secondary to PCNV that developed on the border of a juxtapapillary choroidal nevus. Fluorescein angiography, indocyanine green angiography, and spectral-domain OCT confirmed the diagnosis...
November 28, 2016: European Journal of Ophthalmology
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