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https://www.readbyqxmd.com/read/27878872/immobilizing-molecular-metal-dithiolene-diamine-complexes-on-2d-metal-organic-frameworks-for-electrocatalytic-h2-production
#1
Renhao Dong, Zhikun Zheng, Diana Tranca, Jian Zhang, Naisa Chandrasekhar, Shaohua Liu, Xiaodong Zhuang, Gotthard Seifert, Xinliang Feng
Carbon electrocatalysts consisting of metal complexes (such as MNx and MSx) are promising candidates for use as alternatives to high-cost Pt catalysts for the hydrogen evolution reaction (HER). However, the exact HER active sites remain elusive. Here, we selectively incorporate the molecular metal dithiolene-diamine (MS2N2, M=Co and Ni), metal bis(dithiolene) (MS4), and metal bis(diamine) (MN4) complexes into carbon-rich 2D metal-organic frameworks (2D MOFs) as model carbon electrocatalysts. The 2D MOF single layers, powders, and composites with graphene are thus prepared and devote definite active sites for H2 generation...
November 22, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27853423/ethanol-and-caffeine-effects-on-social-interaction-and-recognition-in-mice-involvement-of-adenosine-a2a-and-a1-receptors
#2
Laura López-Cruz, Noemí San-Miguel, Pilar Bayarri, Younis Baqi, Christa E Müller, John D Salamone, Mercé Correa
Ethanol and caffeine are frequently consumed in combination and have opposite effects on the adenosine system: ethanol metabolism leads to an increase in adenosine levels, while caffeine is a non-selective adenosine A1/A2A receptor antagonist. These receptors are highly expressed in striatum and olfactory tubercle, brain areas involved in exploration and social interaction in rodents. Ethanol modulates social interaction processes, but the role of adenosine in social behavior is still poorly understood. The present work was undertaken to study the impact of ethanol, caffeine and their combination on social behavior, and to explore the involvement of A1 and A2A receptors on those actions...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27694229/identification-of-phosphinothricin-acetyltransferases-using-in-vivo-in-vitro-and-bioinformatics-analyses
#3
Chelsey M VanDrisse, Kristy L Hentchel, Jorge C Escalante-Semerena
Acetylation of small molecules is widespread in nature, and in some cases, cells use this process to detoxify harmful chemicals. Streptomyces species utilize a Gcn5 N-acetyltransferase (GNAT), known as Bar, to acetylate and detoxify a self-produced toxin, phosphinothricin (PPT), a glutamate analogue. Bar homologues, such as MddA from Salmonella enterica acetylate methionine analogues such as methionine sulfoximine (MSX) and methionine sulfone (MSO), but not PPT, even though Bar homologues are annotated as PPT acetyltransferases...
September 30, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27692439/cvd-grown-monolayer-graphene-induces-osteogenic-but-not-odontoblastic-differentiation-of-dental-pulp-stem-cells
#4
Han Xie, Melissa Chua, Intekhab Islam, Ricardo Bentini, Tong Cao, José Carlos Viana-Gomes, Antônio Hélio Castro Neto, Vinicius Rosa
OBJECTIVE: The objective was to investigate the potential of graphene (Gp) to induce odontogenic and osteogenic differentiation in dental pulp stem cells (DPSC). METHODS: Gp was produced by chemical vapor deposition. DPSC were seeded on Gp or glass (Gl). Cells were maintained in culture medium for 28 days. Every two days, culture medium from Gp was used to treat cells on Gl and vice versa. Mineralization and differentiation of DPSC on all substrates were evaluated after 14 and 28 days by alizarin red S staining, qPCR, immunofluorescence and FACS...
September 27, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27689785/methionine-sulfoximine-supplementation-enhances-productivity-in-gs-chok1sv-cell-lines-through-glutathione-biosynthesis
#5
Marc Feary, Andrew J Racher, Robert J Young, C Mark Smales
In Lonza Biologics' GS Gene Expression System™, recombinant protein-producing GS-CHOK1SV cell lines are generated by transfection with an expression vector encoding both GS and the protein product genes followed by selection in MSX and glutamine-free medium. MSX is required to inhibit endogenous CHOK1SV GS, and in effect create a glutamine auxotrophy in the host that can be complemented by the expression vector encoded GS in selected cell lines. However, MSX is not a specific inhibitor of GS as it also inhibits the activity of GCL (a key enzyme in the glutathione biosynthesis pathway) to a similar extent...
September 30, 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/27641728/alkaline-phosphatase-and-oct-3-4-as-useful-markers-for-predicting-susceptibility-of-human-deciduous-teeth-derived-dental-pulp-cells-to-reprogramming-factor-induced-ips-cells
#6
Emi Inada, Issei Saitoh, Naoko Kubota, Miki Soda, Kazunari Matsueda, Tomoya Murakami, Tadashi Sawami, Akiko Kagoshima, Youichi Yamasaki, Masahiro Sato
AIM: The aim of the present study was to prove that primary cells enriched with stem cells are more easily reprogrammed to generate induced pluripotent stem (iPS) cells than those with scarce numbers of stem cells. METHODS: We surveyed the alkaline phosphatase (ALP) activity in five primarily-isolated human deciduous teeth-derived dental pulp cells (HDDPC) with cytochemical staining to examine the possible presence of stem cells. Next, the expression of stemness-specific factors, such as OCT(Octumer-binding transcription factor)3/4, NANOG, SOX2(SRY (sex determining region Y)-box 2), CD90, muscle segment homeodomain homeobox (MSX) 1, and MSX2, was assessed with a reverse transcription polymerase chain reaction method...
September 18, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27497935/effort-related-motivational-effects-of-the-pro-inflammatory-cytokine-interleukin-6-pharmacological-and-neurochemical-characterization
#7
Samantha E Yohn, Yumna Arif, Allison Haley, Guiseppe Tripodi, Younis Baqi, Christa E Müller, Noemi San Miguel, Mercè Correa, John D Salamone
RATIONALE: Motivational dysfunctions such as anergia, fatigue, and reduced effort expenditure are common in patients with depression and other disorders. Pro-inflammatory cytokines are implicated in depression, and cytokine administration induces motivational deficits in humans. OBJECTIVES: These studies focused on the effects of the cytokine interleukin-6 (IL-6) on effort-related decision-making. METHODS: Rats were assessed using the concurrent fixed ratio 5-lever pressing/chow feeding choice procedure, which measures the tendency of rats to work for a preferred food (high carbohydrate pellets) in the presence of a concurrently available but less preferred substitute (lab chow)...
October 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27466333/sustained-hypoxia-elicits-competing-spinal-mechanisms-of-phrenic-motor-facilitation
#8
Michael J Devinney, Nicole L Nichols, Gordon S Mitchell
UNLABELLED: Acute intermittent hypoxia (AIH) induces phrenic long-term facilitation (pLTF), a form of spinal motor plasticity. Competing mechanisms give rise to phrenic motor facilitation (pMF; a general term including pLTF) depending on the severity of hypoxia within episodes. In contrast, moderate acute sustained hypoxia (mASH) does not elicit pMF. By varying the severity of ASH and targeting competing mechanisms of pMF, we sought to illustrate why moderate AIH (mAIH) elicits pMF but mASH does not...
July 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27418278/effects-of-a-standardized-phenolic-enriched-maple-syrup-extract-on-%C3%AE-amyloid-aggregation-neuroinflammation-in-microglial-and-neuronal-cells-and-%C3%AE-amyloid-induced-neurotoxicity-in-caenorhabditis-elegans
#9
Hang Ma, Nicholas A DaSilva, Weixi Liu, Pragati P Nahar, Zhengxi Wei, Yongqiang Liu, Priscilla T Pham, Rebecca Crews, Dhiraj A Vattem, Angela L Slitt, Zahir A Shaikh, Navindra P Seeram
Published data supports the neuroprotective effects of several phenolic-containing natural products, including certain fruit, berries, spices, nuts, green tea, and olive oil. However, limited data are available for phenolic-containing plant-derived natural sweeteners including maple syrup. Herein, we investigated the neuroprotective effects of a chemically standardized phenolic-enriched maple syrup extract (MSX) using a combination of biophysical, in vitro, and in vivo studies. Based on biophysical data (Thioflavin T assay, transmission electron microscopy, circular dichroism, dynamic light scattering, and zeta potential), MSX reduced amyloid β1-42 peptide (Aβ1-42) fibrillation in a concentration-dependent manner (50-500 μg/mL) with similar effects as the neuroprotective polyphenol, resveratrol, at its highest test concentration (63...
July 14, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27312535/reduced-homeobox-protein-msx1-in-human-endometrial-tissue-is-linked-to-infertility
#10
Alan D Bolnick, Jay M Bolnick, Brian A Kilburn, Tamika Stewart, Jonathan Oakes, Javier Rodriguez-Kovacs, Hamid-Reza Kohan-Ghadr, Jing Dai, Michael P Diamond, Yasushi Hirota, Sascha Drewlo, Sudhansu K Dey, D Randall Armant
STUDY QUESTION: Is protein expression of the muscle segment homeobox gene family member MSX1 altered in the human secretory endometrium by cell type, developmental stage or fertility? SUMMARY ANSWER: MSX1 protein levels, normally elevated in the secretory phase endometrium, were significantly reduced in endometrial biopsies obtained from women of infertile couples. WHAT IS KNOWN ALREADY: Molecular changes in the endometrium are important for fertility in both animals and humans...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27283997/graphene-oxide-based-substrate-physical-and-surface-characterization-cytocompatibility-and-differentiation-potential-of-dental-pulp-stem-cells
#11
Vinicius Rosa, Han Xie, Nileshkumar Dubey, Thulasi T Madanagopal, Sneha S Rajan, Julien Luc Paul Morin, Intekhab Islam, Antônio Hélio Castro Neto
OBJECTIVE: The aim of this study was to evaluate the cytotoxicity and differentiation potential of a graphene oxide (GO)-based substrate using dental pulp stem cell (DPSC). METHODS: GO was obtained via chemical exfoliation of graphite using the modified Hummer's method and dispersed in water-methanol solution. 250μL of 1.5mg/mL solution were added to a cover slip and allowed to dry (25°C, 24h). GO-based substrate was characterized by Raman spectroscopy, AFM and contact angle...
August 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27193262/multiplexed-data-independent-acquisition-msx-dia-applied-by-high-resolution-mass-spectrometry-improves-quantification-quality-for-the-analysis-of-histone-peptides
#12
Simone Sidoli, Rina Fujiwara, Benjamin A Garcia
We present the MS-based application of the innovative, although scarcely exploited, multiplexed data-independent acquisition (MSX-DIA) for the analysis of histone PTMs. Histones are golden standard for complexity in MS based proteomics, due to their large number of combinatorial modifications, leading to isobaric peptides after proteolytic digestion. DIA has, thus, gained popularity for the purpose as it allows for MS/MS-based quantification without upfront assay development. In this work, we evaluated the performance of traditional DIA versus MSX-DIA in terms of MS/MS spectra quality, instrument scan rate and quantification precision using histones from HeLa cells...
August 2016: Proteomics
https://www.readbyqxmd.com/read/27151209/nervous-system-development-in-cephalopods-how-egg-yolk-richness-modifies-the-topology-of-the-mediolateral-patterning-system
#13
A Buresi, A Andouche, S Navet, Y Bassaglia, L Bonnaud-Ponticelli, S Baratte
Cephalopods possess the most complex centralized nervous system among molluscs and the molecular determinants of its development have only begun to be explored. To better understand how evolved their brain and body axes, we studied Sepia officinalis embryos and investigated the expression patterns of neural regionalization genes involved in the mediolateral patterning of the neuroectoderm in model species. SoxB1 expression reveals that the embryonic neuroectoderm is made of several distinct territories that constitute a large part of the animal pole disc...
July 1, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27088357/msx2-induces-trophoblast-invasion-in-human-placenta
#14
Hao Liang, Qian Zhang, Junjie Lu, Genling Yang, Na Tian, Xiaojie Wang, Yi Tan, Dongmei Tan
Normal implantation depends on appropriate trophoblast growth and invasion. Inadequate trophoblast invasion results in pregnancy-related disorders, such as early miscarriage and pre-eclampsia, which are dangerous to both the mother and fetus. Msh Homeobox 2 (MSX2), a member of the MSX family of homeobox proteins, plays a significant role in the proliferation and differentiation of various cells and tissues, including ectodermal organs, teeth, and chondrocytes. Recently, MSX2 was found to play important roles in the invasion of cancer cells into adjacent tissues via the epithelial-mesenchymal transition (EMT)...
2016: PloS One
https://www.readbyqxmd.com/read/27066482/wnt-%C3%AE-catenin-regulates-the-activity-of-epiprofin-sp6-shh-fgf-and-bmp-to-coordinate-the-stages-of-odontogenesis
#15
Maitane Aurrekoetxea, Igor Irastorza, Patricia García-Gallastegui, Lucia Jiménez-Rojo, Takashi Nakamura, Yoshihiko Yamada, Gaskon Ibarretxe, Fernando J Unda
BACKGROUND: We used an in vitro tooth development model to investigate the effects of overactivation of the Wnt/β-catenin pathway during odontogenesis by bromoindirubin oxime reagent (BIO), a specific inhibitor of GSK-3 activity. RESULTS: Overactivating the Wnt/β-catenin pathway at tooth initiation upregulated and ectopically expressed the epithelial markers Sonic Hedgehog (Shh), Epiprofin (Epfn), and Fibroblast growth factor8 (Fgf8), which are involved in the delimitation of odontogenic fields in the oral ectoderm...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/26959817/comparative-transcriptome-analysis-of-fetal-skin-reveals-key-genes-related-to-hair-follicle-morphogenesis-in-cashmere-goats
#16
Ye Gao, Xiaolong Wang, Hailong Yan, Jie Zeng, Sen Ma, Yiyuan Niu, Guangxian Zhou, Yu Jiang, Yulin Chen
Cashmere goat skin contains two types of hair follicles (HF): primary hair follicles (PHF) and secondary hair follicles (SHF). Although multiple genetic determinants associated with HF formation have been identified, the molecules that determine the independent morphogenesis of HF in cashmere goats remain elusive. The growth and development of SHF directly influence the quantity and quality of cashmere production. Here, we report the transcriptome profiling analysis of nine skin samples from cashmere goats using 60- and 120-day-old embryos (E60 and E120, respectively), as well as newborns (NB), through RNA-sequencing (RNA-seq)...
2016: PloS One
https://www.readbyqxmd.com/read/26880838/infectious-diseases-of-marine-molluscs-and-host-responses-as-revealed-by-genomic-tools
#17
REVIEW
Ximing Guo, Susan E Ford
More and more infectious diseases affect marine molluscs. Some diseases have impacted commercial species including MSX and Dermo of the eastern oyster, QPX of hard clams, withering syndrome of abalone and ostreid herpesvirus 1 (OsHV-1) infections of many molluscs. Although the exact transmission mechanisms are not well understood, human activities and associated environmental changes often correlate with increased disease prevalence. For instance, hatcheries and large-scale aquaculture create high host densities, which, along with increasing ocean temperature, might have contributed to OsHV-1 epizootics in scallops and oysters...
March 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/26797522/gelatinases-promote-calcification-of-vascular-smooth-muscle-cells-by-up-regulating-bone-morphogenetic-protein-2
#18
Yong-Gang Zhao, Fan-Xing Meng, Bing-Wei Li, You-Ming Sheng, Ming-Ming Liu, Bing Wang, Hong-Wei Li, Rui-Juan Xiu
Matrix metalloproteinase-2 (MMP-2), also known as gelatinase A, is involved in vascular calcification. Another member of gelatinases is MMP-9 (gelatinase B). However, the role of gelatinases in the pathogenesis of vascular calcification is not well understood. The current study aims to clarify the relationship between gelatinases and vascular calcification and to elucidate the underlying mechanism. Beta-glycerophosphate (β-GP) was used to induce calcification of vascular smooth muscle cells (VSMCs) with or without 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]-thiirane (SB-3CT), a specific gelatinases inhibitor...
February 5, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26652425/comparison-of-bare-and-amino-modified-mesoporous-silica-poly-ethyleneimine-s-xerogel-as-indomethacin-carrier-superiority-of-amino-modification
#19
COMPARATIVE STUDY
Jing Li, Lu Xu, Hongyu Wang, Baixue Yang, Hongzhuo Liu, Weisan Pan, Sanming Li
The purpose of this study was to facilely develop amino modified mesoporous silica xerogel synthesized using biomimetic method (B-AMSX) and to investigate its potential ability to be a drug carrier for loading poorly water-soluble drug indomethacin (IMC). For comparison, mesoporous silica xerogel without amino modification (B-MSX) was also synthesized using the same method. The changes of characteristics before and after IMC loading were systemically studied using fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), small angle X-ray scattering (SAXS) and nitrogen adsorption/desorption analysis...
February 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/26635369/the-molecular-basis-of-tnra-control-by-glutamine-synthetase-in-bacillus-subtilis
#20
Ksenia Hauf, Airat Kayumov, Felix Gloge, Karl Forchhammer
TnrA is a master regulator of nitrogen assimilation in Bacillus subtilis. This study focuses on the mechanism of how glutamine synthetase (GS) inhibits TnrA function in response to key metabolites ATP, AMP, glutamine, and glutamate. We suggest a model of two mutually exclusive GS conformations governing the interaction with TnrA. In the ATP-bound state (A-state), GS is catalytically active but unable to interact with TnrA. This conformation was stabilized by phosphorylated L-methionine sulfoximine (MSX), fixing the enzyme in the transition state...
February 12, 2016: Journal of Biological Chemistry
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