keyword
https://read.qxmd.com/read/38448751/prrx1-top2a-interaction-is-a-malignancy-promoting-factor-in-human-malignant-peripheral-nerve-sheath-tumours
#21
JOURNAL ARTICLE
Shota Takihira, Daisuke Yamada, Tatsunori Osone, Tomoka Takao, Masakiyo Sakaguchi, Michiyuki Hakozaki, Takuto Itano, Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Toshifumi Ozaki, Takeshi Takarada
BACKGROUND: Paired related-homeobox 1 (PRRX1) is a transcription factor in the regulation of developmental morphogenetic processes. There is growing evidence that PRRX1 is highly expressed in certain cancers and is critically involved in human survival prognosis. However, the molecular mechanism of PRRX1 in cancer malignancy remains to be elucidated. METHODS: PRRX1 expression in human Malignant peripheral nerve sheath tumours (MPNSTs) samples was detected immunohistochemically to evaluate survival prognosis...
March 6, 2024: British Journal of Cancer
https://read.qxmd.com/read/38447947/bilateral-foramina-parietalia-permagna-a-calvarial-defect-caused-by-haploinsufficiency-of-the-msh-homeobox-2-gene-a-case-report-and-current-literature-review
#22
JOURNAL ARTICLE
Niklas Kahl, Natalia Lüsebrink, Susanne Schubert-Bast, Thomas M Freiman, Matthias Kieslich
Foramina parietalia permagna (FPP) is a rare anatomical defect that affects the parietal bones of the human skull. FPP is characterized by symmetric perforations on either side of the skull, which are caused by insufficient ossification during embryogenesis. These openings are typically abnormally large and can range from a few millimeters to several centimeters in diameter. Enlarged foramina are often discovered incidentally during anatomical or radiological examinations and in most cases left untreated unless symptoms develop...
March 6, 2024: Neuropediatrics
https://read.qxmd.com/read/38446849/generation-of-human-excitatory-forebrain-neurons-by-cooperative-binding-of-proneural-ngn2-and-homeobox-factor-emx1
#23
JOURNAL ARTICLE
Cheen Euong Ang, Victor Hipolito Olmos, Kayla Vodehnal, Bo Zhou, Qian Yi Lee, Rahul Sinha, Aadit Narayanaswamy, Moritz Mall, Kirill Chesnov, Caia S Dominicus, Thomas Südhof, Marius Wernig
Generation of defined neuronal subtypes from human pluripotent stem cells remains a challenge. The proneural factor NGN2 has been shown to overcome experimental variability observed by morphogen-guided differentiation and directly converts pluripotent stem cells into neurons, but their cellular heterogeneity has not been investigated yet. Here, we found that NGN2 reproducibly produces three different kinds of excitatory neurons characterized by partial coactivation of other neurotransmitter programs. We explored two principle approaches to achieve more precise specification: prepatterning the chromatin landscape that NGN2 is exposed to and combining NGN2 with region-specific transcription factors...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38444400/association-between-the-hhex-polymorphism-and-delayed-memory-in-first-episode-schizophrenic-patients
#24
JOURNAL ARTICLE
Zhen Hua Zhu, Xu Yuan Yin, Yuan Cai, Ning Ning Jia, Pei Jie Wang, Qi Qi, Wen Long Hou, Li Juan Man, Li Hui
The hematopoietically-expressed homeobox gene ( HHEX ) played a critical role in regulating the immune system that the abnormality of which was involved in the psychopathology and cognitive deficits of psychiatric disorders. The aim of this study was to investigate the effect of HHEX rs1111875 polymorphism on the susceptibility and cognitive deficits of first-episode schizophrenic patients (FSP). We assessed cognitive function in 239 first-episode patients meeting DSM-IV for schizophrenia, and 368 healthy controls using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)...
June 2024: Schizophrenia Research. Cognition
https://read.qxmd.com/read/38443352/key-homeobox-transcription-factors-regulate-the-development-of-the-firefly-s-adult-light-organ-and-bioluminescence
#25
JOURNAL ARTICLE
Xinhua Fu, Xinlei Zhu
Adult fireflies exhibit unique flashing courtship signals, emitted by specialized light organs, which develop mostly independently from larval light organs during the pupal stage. The mechanisms of adult light organ development have not been thoroughly studied until now. Here we show that key homeobox transcription factors AlABD-B and AlUNC-4 regulate the development of adult light organs and bioluminescence in the firefly Aquatica leii. Interference with the expression of AlAbd-B and AlUnc-4 genes results in undeveloped or non-luminescent adult light organs...
March 5, 2024: Nature Communications
https://read.qxmd.com/read/38441675/wox2-functions-redundantly-with-wox1-and-wox4-to-positively-regulate-seed-germination-in-arabidopsis
#26
JOURNAL ARTICLE
Yue Yang, Ziyun Ren, Lei Li, Yu Li, Yi Han, Yongxiu Liu, Hong Cao
WOX family gene WOX2 is highly expressed during seed development, which functions redundantly with WOX1 and WOX4 to positively regulate seed germination. WOX (WUSCHEL-related homeobox) is a family of transcription factors in plants. They play essential roles in the regulation of plant growth and development, but their function in seed germination is not well understood. In this report, we show that WOX1, WOX2, and WOX4 are close homologues in Arabidopsis. WOX2 has a redundant function with WOX1 and WOX4, respectively, in seed germination...
March 5, 2024: Planta
https://read.qxmd.com/read/38439814/loss-of-cdx2-and-high-cox2-ptgs2-expression-in-metastatic-colorectal-cancer
#27
JOURNAL ARTICLE
Álvaro M C Caldas, Warley A Nunes, Rodrigo Taboada, Marcelle G Cesca, Janaína N Germano, Rachel P Riechelmann
Lack of expression of the tumour suppressor gene caudal-type homeobox 2 ( CDX2 ) associates with poor outcomes in early stage colorectal cancer (CRC). Yet its prognostic value in the context of other prognostic biomarkers in metastatic CRC (mCRC) is unknown. Overexpressed cyclooxygenase-2 (COX2) has been reported in advanced CRC. However, CDX2 and COX2 relationship in mCRC remains undetermined. We aimed to assess their expression in mCRC tumours from a clinically characterised cohort and their influence on overall survival (OS) and progression-free survival (PFS) in first line...
2024: Ecancermedicalscience
https://read.qxmd.com/read/38431750/decoding-the-leaf-apical-meristem-of-guarea-glabra-vahl-meliaceae-insight-into-the-evolution-of-indeterminate-pinnate-leaves
#28
JOURNAL ARTICLE
Yasutake Moriyama, Hiroyuki Koga, Hirokazu Tsukaya
In seed plants, growth of shoots and roots is indeterminate, while leaves are typically determinate organs that cease to grow after a certain developmental stage. This is due to the characteristics of the leaf meristem, where cell proliferation activity is retained only for a limited period. However, several plants exhibit indeterminacy in their leaves, exemplified by the pinnate compound leaves of Guarea and Chisocheton genera in the Meliaceae family. In these plants, the leaf meristem at the tip of the leaf retains meristematic activity and produces leaflets over years, resulting in a single leaf that resembles a twig...
March 2, 2024: Scientific Reports
https://read.qxmd.com/read/38428218/a-preliminary-therapeutic-study-of-the-effects-of-molecular-hydrogen-on-intestinal-dysbiosis-and-small-intestinal-injury-in-high-fat-diet-loaded-senescence-accelerated-mice
#29
JOURNAL ARTICLE
Sayaka Takahashi, Keiichi Nakagawa, Wataru Nagata, Akiho Koizumi, Toshiaki Ishizuka
OBJECTIVES: Aging and excessive fat intake may additively induce dysbiosis of the gut microbiota and intestinal inflammatory damage. Here, we analyzed microbiota dysbiosis and intestinal injury in high-fat diet-loaded senescence-accelerated mice (SAMP8). Additionally, we examined whether treatment with molecular hydrogen could improve the intestinal environment. METHODS: SAMP8 and SAMR1 (control) mice were first fed a normal diet (ND) or high-fat diet (HFD) for 10 wk (n = 10 each group)...
February 5, 2024: Nutrition
https://read.qxmd.com/read/38422767/mir-128-3p-alleviates-airway-inflammation-in-asthma-by-targeting-six1-to-regulate-mitochondrial-fission-and-fusion
#30
JOURNAL ARTICLE
Xiaohan Liu, Hong Cui, Qiaoyun Bai, Hongmei Piao, Yilan Song, Guanghai Yan
Bronchial asthma is known for airway inflammation, hyperresponsiveness, and remodeling.MicroRNAs (MiRNAs) have been involved in the development of asthma, whereas, the mechanism of various MiRNAs in asthma remains to be elucidated. In this study, we aim to explore the mechanism of miR-128-3p in asthma-related airway inflammation by targeting sine oculis homeobox homolog 1 (SIX1) to regulate the mitochondrial function. In an ovalbumin (OVA) asthma mouse model, miR-128-3p levels were found to be significantly diminished...
February 28, 2024: International Immunopharmacology
https://read.qxmd.com/read/38421703/overexpression-of-homeobox-a1-relieves-ovalbumin-induced-asthma-in-mice-and-is-associated-with-blocking-of-the-nf-%C3%AE%C2%BAb-signaling-pathway
#31
JOURNAL ARTICLE
Jianye Yang, Wenbin Hu, Jiaming Zhao
Homeobox A1 (HOXA1) is a protein coding gene involved in regulating immunity signaling. This study aims to explore the function and mechanism of HOXA1 in asthma. An asthma mouse model was established via ovalbumin (OVA) induction. Airway hyperresponsiveness was evaluated by the value of pause enhancement (Penh). Inflammatory cells in bronchoalveolar lavage fluid (BALF) were detected by Trypan blue and Wright staining. The pathological morphology of lung tissues was assessed by H&E staining. The IgE and inflammatory biomarkers (IL-1β, IL-6, IL-17, and TNF-α) in BALF and lung tissues were measured by ELISA...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/38421174/regulatory-functions-of-homeobox-domain-transcription-factors-in-fungi
#32
REVIEW
A M Calvo, A Dabholkar, E M Wyman, J M Lohmar, J W Cary
Homeobox domain (HD) proteins present a crucial involvement in morphological differentiation and other functions in eukaryotes. Most HD genes encode transcription factors (TFs) that orchestrate a regulatory role in cellular and developmental decisions. In fungi, multiple studies have increased our understanding of these important HD regulators in recent years. These reports have revealed their role in fungal development, both sexual and asexual, as well as their importance in governing other biological processes in these organisms, including secondary metabolism, pathogenicity, and sensitivity to environmental stresses...
February 29, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38414750/transcriptional-precision-in-photoreceptor-development-and-diseases-lessons-from-25-years-of-crx-research
#33
REVIEW
Yiqiao Zheng, Shiming Chen
The vertebrate retina is made up of six specialized neuronal cell types and one glia that are generated from a common retinal progenitor. The development of these distinct cell types is programmed by transcription factors that regulate the expression of specific genes essential for cell fate specification and differentiation. Because of the complex nature of transcriptional regulation, understanding transcription factor functions in development and disease is challenging. Research on the Cone-rod homeobox transcription factor CRX provides an excellent model to address these challenges...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38410214/downregulation-of-homeobox-b8-in-attenuating-non-small-cell-lung-cancer-cell-migration-and-invasion-though-the-epithelial-mesenchymal-transition-pathway
#34
JOURNAL ARTICLE
Suxin Jiang, Tao Wang, Yong Han, Toyoaki Hida, Muhammad Zubair Afzal, Chuanhong Zhou, Jingna Zhu, Huaiyu Wang
BACKGROUND: Homeobox ( HOX ) family genes have been identified as regulators of cancer development. No research exists concerning the mechanisms underlying homeobox B8 ( HOXB8 ) activity in non-small cell lung cancer (NSCLC). In this study, we investigated expression and biological function in NSCLC to determine whether it is an important marker of patient prognosis. METHODS: HOXB8 expression in NSCLC tissues was investigated using immunohistochemistry (IHC) and Western blot assays...
January 31, 2024: Translational Cancer Research
https://read.qxmd.com/read/38404736/haploinsufficiency-of-nkx2-1-is-likely-to-contribute-to-developmental-delay-involving-14q13-microdeletions
#35
JOURNAL ARTICLE
Osamu Machida, Haruko Sakamoto, Keiko Shimojima Yamamoto, Yuiko Hasegawa, Satoi Nii, Hidenori Okada, Kazuki Nishikawa, Shin-Ichi Sumimoto, Eriko Nishi, Nobuhiko Okamoto, Toshiyuki Yamamoto
Nucleotide variations or deletions in the NK2 homeobox 1 gene ( NKX2-1 ), located at 14q13.3, lead to symptoms associated with the brain, lungs, and thyroid, and the combination of these phenotypes is clinically recognized as the brain-lung-thyroid syndrome. Many types of nucleotide variants of NKX2-1 have been identified, and phenotypic variability has been reported. Chromosomal deletions involving NKX2-1 have also been reported; however, phenotypic differences between patients with nucleotide variants of NKX2-1 and patients with chromosomal deletions involving NKX2-1 have not been well established...
February 2024: Intractable & Rare Diseases Research
https://read.qxmd.com/read/38404687/pbx1-a-tale-of-two-seasons-key-roles-during-development-and-in-cancer
#36
REVIEW
Laura Crisafulli, Matteo Brindisi, Mirko Giuseppe Liturri, Cristina Sobacchi, Francesca Ficara
Pre-B cell leukemia factor 1 (PBX1) is a Three Aminoacid Loop Extension (TALE) homeodomain-containing transcription factor playing crucial roles in organ pattering during embryogenesis, through the formation of nuclear complexes with other TALE class and/or homeobox proteins to regulate target genes. Its contribution to the development of several organs has been elucidated mainly through the study of murine knockout models. A crucial role for human development has been recently highlighted through the discovery of different de novo pathogenic PBX1 variants in children affected by developmental defects...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38403966/an-unusual-ophthalmologic-finding-in-a-patient-with-congenital-central-hypoventilation-syndrome
#37
JOURNAL ARTICLE
Víctor Aguado-Casanova, Diana Pérez-García, Marta Orejudo-Rivas, Patricia Ramiro-Millán, Juan Ibañez-Alperte, Cristina Calvo-Simon, Leon Remón
INTRODUCTION: Congenital Central Hypoventilation Syndrome (CCHS) is a rare disease due to a severely impaired central control of breathing and dysfunction of the autonomic nervous system. Ophthalmologic abnormalities are common in patients with CCHS and include horizontal strabismus, pupil and iris abnormalities and ptosis. We report a unique case of CCHS in association with monocular elevation deficit (MED) in a boy diagnosed with CCHS at birth. CASE DESCRIPTION: We report a case of a boy with a confirmed diagnosis of CCHS (complete sequencing of the paired-like homeobox 2b (PHOX2B) gene) after presenting little respiratory effort and cyanosis at birth...
February 25, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38403573/defective-exercise-related-expiratory-muscle-recruitment-in-patients-with-phox2b-mutations-a-clue-to-neural-determinants-of-the-congenital-central-hypoventilation-syndrome
#38
JOURNAL ARTICLE
P Laveneziana, Q Fossé, M Bret, M Patout, B Dudoignon, C Llontop, C Morélot-Panzini, F Cayetanot, L Bodineau, C Straus, T Similowski
INTRODUCTION AND OBJECTIVES: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study...
February 24, 2024: Pulmonology
https://read.qxmd.com/read/38400608/type-1-early-infantile-epileptic-encephalopathy-a-case-report-and-literature-review
#39
REVIEW
Erfan Zaker, Negar Nouri, Mojtaba Movahedinia, Ali Dadbinpour, Mohammad Yahya Vahidi Mehrjardi
BACKGROUND: Variants in the Aristaless-related homeobox (ARX) gene lead to a variety of phenotypes, with intellectual disability being a steady feature. Other features can include severe epilepsy, spasticity, movement disorders, hydranencephaly, and ambiguous genitalia in males. X-linked Ohtahara syndrome or Type 1 early infantile epileptic encephalopathy (EIEE1) is a severe early-onset epileptic encephalopathy with arrested psychomotor development caused by hemizygous mutations in the ARX gene, which encodes a transcription factor in fundamental brain developmental processes...
February 2024: Molecular Genetics & Genomic Medicine
https://read.qxmd.com/read/38396864/transcriptome-analysis-and-metabolic-profiling-reveal-the-key-regulatory-pathways-in-drought-stress-responses-and-recovery-in-tomatoes
#40
JOURNAL ARTICLE
Jinshuai Shu, Lili Zhang, Guiming Liu, Xiaoxuan Wang, Fuzhong Liu, Ying Zhang, Yuhui Chen
Drought stress is a major abiotic factor affecting tomato production and fruit quality. However, the genes and metabolites associated with tomato responses to water deficiency and rehydration are poorly characterized. To identify the functional genes and key metabolic pathways underlying tomato responses to drought stress and recovery, drought-susceptible and drought-tolerant inbred lines underwent transcriptomic and metabolomic analyses. A total of 332 drought-responsive and 491 rehydration-responsive core genes were robustly differentially expressed in both genotypes...
February 11, 2024: International Journal of Molecular Sciences
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