keyword
https://read.qxmd.com/read/38490377/porcine-transient-receptor-potential-channel-1-trpc1-regulates-muscle-growth-via-the-wnt-%C3%AE-catenin-and-wnt-ca-2-pathways
#1
JOURNAL ARTICLE
Xin Hao, Yu Fu, Shixin Li, Jingru Nie, Bo Zhang, Hao Zhang
Transient receptor potential canonical (TRPC) channels allow the intracellular entry of Ca2+ and play important roles in several physio-pathological processes. In this study, we constructed transgenic mice expressing porcine TRPC1 (Tg-pTRPC1) to verify the effects of TRPC1 on skeletal muscle growth and elucidate the underlying mechanism. Porcine TRPC1 increased the muscle mass, fiber cross-sectional area, and exercise endurance of mice and accelerated muscle repair and regeneration. TRPC1 overexpression enhanced β-catenin expression and promoted myogenesis, which was partly reversed by inhibitors of β-catenin...
March 13, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38489602/the-oseil1-oswox11-transcription-factor-module-controls-rice-crown-root-development-in-response-to-soil-compaction
#2
JOURNAL ARTICLE
Yuxiang Li, Juan Wang, Yadi Gao, Bipin K Pandey, Lucas León Peralta Ogorek, Yu Zhao, Ruidang Quan, Zihan Zhao, Lei Jiang, Rongfeng Huang, Hua Qin
Optimizing the root architecture of crops is an effective strategy for improving crop yields. Soil compaction is a serious global problem that limits crop productivity by restricting root growth, but the underlying molecular mechanisms are largely unclear. Here, we show that ethylene stimulates rice (Oryza sativa) crown root development in response to soil compaction. First, we demonstrate that compacted soil promotes ethylene production and the accumulation of ETHYLENE INSENSITIVE 3-LIKE 1 (OsEIL1) in rice roots, stimulating crown root primordia initiation and development, thereby increasing crown root number in lower stem nodes...
March 15, 2024: Plant Cell
https://read.qxmd.com/read/38488445/real-time-field-programmable-gate-array-based-closed-loop-deep-brain-stimulation-platform-targeting-cerebellar-circuitry-rescues-motor-deficits-in-a-mouse-model-of-cerebellar-ataxia
#3
JOURNAL ARTICLE
Gajendra Kumar, Zhanhong Zhou, Zhihua Wang, Kin Ming Kwan, Chung Tin, Chi Him Eddie Ma
AIMS: The open-loop nature of conventional deep brain stimulation (DBS) produces continuous and excessive stimulation to patients which contributes largely to increased prevalence of adverse side effects. Cerebellar ataxia is characterized by abnormal Purkinje cells (PCs) dendritic arborization, loss of PCs and motor coordination, and muscle weakness with no effective treatment. We aim to develop a real-time field-programmable gate array (FPGA) prototype targeting the deep cerebellar nuclei (DCN) to close the loop for ataxia using conditional double knockout mice with deletion of PC-specific LIM homeobox (Lhx)1 and Lhx5, resulting in abnormal dendritic arborization and motor deficits...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38485033/zeb2-alleviates-hirschsprung-s-associated-enterocolitis-by-promoting-the-proliferation-and-differentiation-of-enteric-neural-precursor-cells-via-the-notch-1-jagged-2-pathway
#4
JOURNAL ARTICLE
Yong Feng, Chonggao Zhou, Fan Zhao, Tidong Ma, Yong Xiao, Kun Peng, Renpeng Xia
BACKGROUND: Hirschsprung's-associated enterocolitis (HAEC) is a prevalent complication of Hirschsprung's disease (HSCR). Zinc finger E-box binding homeobox 2 (ZEB2) and Notch-1/Jagged-2 are dysregulated in HSCR, but their role in HAEC progression remains poorly understood. We aimed to explore the role and underlying mechanism of enteric neural precursor cells (ENPCs) and the ZEB2/Notch-1/Jagged-2 pathway in HAEC development. METHODS: Colon tissues were collected from HSCR and HAEC patients...
March 12, 2024: Gene
https://read.qxmd.com/read/38481182/the-mechanism-of-pfk-1-in-the-occurrence-and-development-of-bladder-cancer-by-regulating-zeb1-lactylation
#5
JOURNAL ARTICLE
Rong Wang, Fei Xu, Zhengjia Yang, Jian Cao, Liqi Hu, Yangyang She
BACKGROUND: Bladder cancer (BC) is one of the most common malignancies of the genitourinary system. Phosphofructokinase 1 (PFK-1) is one of member of PFK, which plays an important role in reprogramming cancer metabolism, such as lactylation modification. Zinc finger E-box-binding homeobox 1 (ZEB1) has been demonstrated to be a oncogene in many cancers. Therefore, this study was performed to explore the effects of PFK-1 on the lactylation of ZEB1 in BC development. METHODS: Cell viability was measured using the CCK-8 kit...
March 13, 2024: BMC Urology
https://read.qxmd.com/read/38479653/exploring-the-patterns-of-evolution-core-thoughts-and-focus-on-the-saltational-model
#6
REVIEW
Gabriele Usai, Marco Fambrini, Claudio Pugliesi, Samuel Simoni
The Modern Synthesis, a pillar in biological thought, united Darwin's species origin concepts with Mendel's laws of character heredity, providing a comprehensive understanding of evolution within species. Highlighting phenotypic variation and natural selection, it elucidated the environment's role as a selective force, shaping populations over time. This framework integrated additional mechanisms, including genetic drift, random mutations, and gene flow, predicting their cumulative effects on microevolution and the emergence of new species...
March 11, 2024: Bio Systems
https://read.qxmd.com/read/38479183/specific-transcription-factors-ascl1-and-lhx6-attenuate-diabetic-neuropathic-pain-by-modulating-spinal-neuroinflammation-and-microglial-activation-in-mice
#7
JOURNAL ARTICLE
Sung-Min Hwang, Md Mahbubur Rahman, Eun Jin Go, Yong Ho Kim, Chul-Kyu Park
Gamma-aminobutyric acid (GABA) neuronal system-related transcription factors (TFs) play a critical role in GABA production, and GABA modulates diabetic neuropathic pain (DNP). The present study investigated the therapeutic effects of intrathecal delivery of two TFs achaete-scute homolog 1 (Ascl1) and LIM homeobox protein 6 (Lhx6) in a mouse model of DNP and elucidated their underlying mechanisms. GABA-related specific TFs, including Ascl1, Lhx6, distal-less homeobox 1, distal-less homeobox 5, the Nkx2.1 homeobox gene, and the Nkx2...
March 12, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38477942/hoxa1-silencing-inhibits-cisplatin-resistance-of-oral-squamous-cell-carcinoma-cells-via-i%C3%AE%C2%BAb-nf-%C3%AE%C2%BAb-signaling-pathway
#8
JOURNAL ARTICLE
Ruifeng Zhu, Yiting Mao, Xianzhi Xu, Yingying Li, Jiwei Zheng
The resistance of oral squamous cell carcinoma (OSCC) cells to cisplatin remains a tough nut to crack in OSCC therapy. Homeobox A1 (HOXA1) overexpression has been detected in head and neck squamous carcinoma (HNSC). Accordingly, this study aims to explore the potential role and mechanism of HOXA1 on cisplatin resistance in OSCC. The expression of HOXA1 in HNSC and its role in overall survival (OS) rate of OSCC patients were analyzed by bioinformatic analysis. Following transfection as needed, OSCC cells were induced by different concentrations of cisplatin, and the cell viability and apoptosis were evaluated by cell counting kit-8 and flow cytometry assays...
March 12, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38476800/diagnostic-challenges-of-sinonasal-pleomorphic-adenoma
#9
Stefan Konsulov, Denis Milkov, Daniel Markov, Elena G Poryazova
Pleomorphic adenomas (PAs) are benign tumors of the salivary glands. Rarely, they arise in the sinonasal cavity, presenting as well-defined, homogeneous soft tissue masses, causing expansive bony changes. The significance of PAs is the possibility of giving rise to malignant carcinoma - "carcinoma ex-pleomorphic adenoma" (CXPA).Here, we present the case of a 64-year-old female complaining of progressive unilateral congestion and external nose deformation, mostly along the left contour of the radix, with epiphora of the ipsilateral eye...
February 2024: Curēus
https://read.qxmd.com/read/38475567/genome-wide-identification-and-co-expression-networks-of-wox-gene-family-in-nelumbo-nucifera
#10
JOURNAL ARTICLE
Juan-Juan Li, Xiao-Yan Qiu, Yu-Jun Dai, Tonny M Nyonga, Chang-Chun Li
WUSCHEL-related homeobox ( WOX ) genes are a class of plant-specific transcription factors, regulating the development of multiple tissues. However, the genomic characterizations and expression patterns of WOX genes have not been analyzed in lotus. In this study, 15 NnWOX genes were identified based on the well-annotated reference genome of lotus. According to the phylogenetic analysis, the NnWOX genes were clustered into three clades, i.e., ancient clade, intermediate clade, and WUS clade. Except for the conserved homeobox motif, we further found specific motifs of NnWOX genes in different clades and divergence gene structures, suggesting their distinct functions...
March 4, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38474085/mowat-wilson-syndrome-case-report-and-review-of-zeb2-gene-variant-types-protein-defects-and-molecular-interactions
#11
Caroline St Peter, Waheeda A Hossain, Scott Lovell, Syed K Rafi, Merlin G Butler
Mowat-Wilson syndrome (MWS) is a rare genetic neurodevelopmental congenital disorder associated with various defects of the zinc finger E-box binding homeobox 2 ( ZEB2 ) gene. The ZEB2 gene is autosomal dominant and encodes six protein domains including the SMAD-binding protein, which functions as a transcriptional corepressor involved in the conversion of neuroepithelial cells in early brain development and as a mediator of trophoblast differentiation. This review summarizes reported ZEB2 gene variants, their types, and frequencies among the 10 exons of ZEB2 ...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474011/transcriptional-landscape-of-cut-class-homeobox-genes-in-blastic-plasmacytoid-dendritic-cell-neoplasm
#12
JOURNAL ARTICLE
Stefan Nagel, Ulfert Rand, Claudia Pommerenke, Corinna Meyer
Homeobox genes encode developmental transcription factors regulating tissue-specific differentiation processes and drive cancerogenesis when deregulated. Dendritic cells (DCs) are myeloid immune cells occurring as two types, either conventional or plasmacytoid DCs. Recently, we showed that the expression of NKL-subclass homeobox gene VENTX is restricted to conventional DCs, regulating developmental genes. Here, we identified and investigated homeobox genes specifically expressed in plasmacytoid DCs (pDCs) and derived blastic plasmacytoid dendritic cell neoplasm (BPDCN)...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38467313/recurrence-of-cchs-associated-phox2b-poly-alanine-expansion-variant-due-to-paternal-mosaicism
#13
JOURNAL ARTICLE
Huling Jiang, Zepeng Ping, Suping Li, Jianjun Zhu
BACKGROUND: Paired-like Homeobox 2B (PHOX2B) is considered the causative gene of Congenital Central Hypoventilation Syndrome (CCHS), a dominant genetic disorder characterized by impaired central respiratory control and subsequent hypoventilation during sleep. METHODS: Herein, we present a family with recurrent severe CCHS. The potential causative genetic variant was confirmed through Whole-Exome Sequencing (WES), Sanger sequencing, and droplet digital PCR (ddPCR)...
March 9, 2024: Gene
https://read.qxmd.com/read/38465368/structural-insights-into-the-recognition-of-the-a-t-rich-motif-in-target-gene-promoters-by-the-lmx1a-homeobox-domain
#14
JOURNAL ARTICLE
Liqing Lin, Jie Deng, Junhui Peng, Jing Cui, Lei Wang, Min Zhang, Jia Gao, Fudong Li, Yunyu Shi, Mengqi Lv
LIM homeodomain transcription factor 1-alpha (LMX1a) is a neuronal lineage-specific transcription activator that plays an essential role during the development of midbrain dopaminergic (mDA) neurons. LMX1a induces the expression of multiple key genes, which ultimately determine the morphology, physiology, and functional identity of mDA neurons. This function of LMX1a is dependent on its homeobox domain. Here, we determined the structures of the LMX1a homeobox domain in complex with the promoter sequences of the Wnt family member 1 (WNT1) or paired like homeodomain 3 (Pitx3) gene, respectively...
March 11, 2024: FEBS Journal
https://read.qxmd.com/read/38459853/the-rejuvenation-and-functional-restoration-of-aged-adipose-stem-cells-by-duxap10-knockdown-via-the-regulation-of-the-mir-214-3p-rassf5-axis
#15
JOURNAL ARTICLE
Sen Ren, Chengcheng Li, Hewei Xiong, Qian Wu, Xiaohui Wu, Zhongwei Xiong, Lixing Dong, Bing Shu, Wei Wei, Chao Ma, Xiang Li, Jincao Chen
Adipose stem cell (ASC)-based therapies provide an encouraging option for tissue repair and regeneration. However, the function of these cells declines with aging, which limits their clinical transformation. Recent studies have outlined the involvement of long non-coding RNAs in stem cell aging. Here, we reanalyzed our published RNA sequencing (RNA-seq) data profiling differences between ASCs from young and old donors and identified a lncRNA named double homeobox A pseudogene 10 (DUXAP10) as significantly accumulated in aged ASCs...
March 9, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38458747/phox2b-a-diagnostic-cornerstone-in-neurocristopathies-and-neuroblastomas
#16
JOURNAL ARTICLE
Mei-Lan Windels, Fleur Cordier, Jo Van Dorpe, Liesbeth Ferdinande, David Creytens
Paired-like homeobox 2B ( PHOX2B ) is a gene essential in the development of the autonomic nervous system. PHOX2B mutations are associated with neurocristopathies-Hirschsprung disease (HSCR) and congenital central hypoventilation syndrome (CCHS)-and peripheral neuroblastic tumours. PHOXB2 plays an important role in the diagnostics of these conditions.Genotyping of a PHOX2B pathogenic variant is required to establish a diagnosis of CCHS. In HSCR patients, PHOX2B immunohistochemical staining has proven to be a valuable tool in identifying this disease...
March 8, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38454954/pulmonary-hypertension-in-an-adult-patient-with-congenital-central-hypoventilation-syndrome-a-case-report
#17
Yosuke Terui, Shoko Ohura, Tetsuji Nozaki, Takuya Yagi
BACKGROUND: Congenital central hypoventilation syndrome (CCHS) is a life-threatening disorder of autonomic respiratory control. Mutations in the paired-like homeobox 2B (PHOX2B) gene impair respiratory drive, causing hypercarbia and hypoxaemia. Most patients with CCHS are diagnosed in the neonatal period; however, a few are diagnosed in adulthood. CASE SUMMARY: We report a 32-year-old man with a history of unexplained cyanosis 14 days after birth. He presented to our hospital with breathlessness and abnormal electrocardiogram findings discovered in a health check-up...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38452706/generation-of-a-isl1-homozygous-knockout-stem-cell-line-wae009-a-1g-by-episomal-vector-based-crispr-cas9-system
#18
JOURNAL ARTICLE
Xiaojie Hou, Wei Fan, Jun Zeng, Zhen Gao, Juyi Wan, Bin Liao
The ISL LIM homeobox 1 (ISL1) gene belongs to the LIM/homeodomain transcription factor family and plays a pivotal role in conveying multipotent and proliferative properties of cardiac precursor cells. Mutations in ISL1 are linked to congenital heart disease. To further explore ISL1's role in the human heart, we have created a homozygous ISL1 knockout (ISL1-KO) human embryonic stem cell line using the CRISPR/Cas9 system. Notably, this ISL1-KO cell line retains normal morphology, pluripotency, and karyotype. This resource serves as a valuable tool for investigating ISL1's function in cardiomyocyte differentiation...
March 4, 2024: Stem Cell Research
https://read.qxmd.com/read/38451434/microrna-124-3p-modulates-alpha-synuclein-expression-levels-in-a-paraquat-induced-in-vivo-model-for-parkinson-s-disease
#19
JOURNAL ARTICLE
Marta Esteves, Ana Clara Cristóvão, Ana Vale, Marta Machado-Pereira, Raquel Ferreira, Liliana Bernardino
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease and the most common movement disorder. Although PD etiology is not fully understood, alpha (α)-synuclein is a key protein involved in PD pathology. MicroRNAs (miRNA), small gene regulatory RNAs that control gene expression, have been identified as biomarkers and potential therapeutic targets for brain diseases, including PD. In particular, miR-124 is downregulated in the plasma and brain samples of PD patients. Recently we showed that the brain delivery of miR-124 counteracts 6-hydroxydopamine-induced motor deficits...
March 7, 2024: Neurochemical Research
https://read.qxmd.com/read/38449391/the-deubiquitinase-brcc3-increases-the-stability-of-zeb1-and-promotes-the-proliferation-and-metastasis-of-triple-negative-breast-cancer-cells
#20
JOURNAL ARTICLE
Qidi Huang, Shurong Zheng, Huayan Gu, Zhi Yang, Yiqiao Lu, Xia Yu, Guilong Guo
Triple negative breast cancer (TNBC) has a high recurrence rate, metastasis rate and mortality rate. The aim of this study is to identify new targets for the treatment of TNBC. Clinical samples are used for screening deubiquitinating enzymes (DUBs). MDA-MB-231 cells and a TNBC mouse model are used for in vitro and in vivo experiments, respectively. Western blot analysis is used to detect the protein expressions of DUBs, zinc finger E-box binding homeobox 1 (ZEB1), and epithelial-mesenchymal transition (EMT)-related markers...
March 7, 2024: Acta Biochimica et Biophysica Sinica
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