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https://www.readbyqxmd.com/read/27852143/reliability-and-validity-of-the-cogstate-computerized-battery-in-patients-with-seizure-disorders-and-healthy-young-adults-comparison-with-standard-neuropsychological-tests
#1
Sara Fratti, Stephen C Bowden, Mark J Cook
OBJECTIVE: The aim was to examine the reliability and validity of two measures of learning and memory within the CogState Computerized Battery: the One Card Learning (OCL) and the Continuous Paired Associative Learning (CPAL). Comparison of various reliable change measures was also included to examine rate of correct cognitive change classification, in particular, when using the Within-Subject Standard Deviation (WSD). METHOD: The OCL and the CPAL tests were administered twice and compared to standard and experimental versions of conventional neuropsychological tests in patients with seizure disorders (Baseline n = 80, Follow-up = 54) and university students (Baseline n = 89, Follow-up n = 87)...
November 17, 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27785907/associations-between-cognitive-impairment-and-patient-reported-measures-of-physical-mental-functioning-in-older-people-living-with-hiv
#2
J Underwood, D De Francesco, F A Post, J H Vera, I Williams, M Boffito, P W Mallon, J Anderson, M Sachikonye, C Sabin, A Winston
OBJECTIVES: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. METHODS: We tested cognitive function using a computerized battery (CogState(™) ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 years participating in the Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study...
October 26, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27777038/acute-effects-on-cognitive-performance-following-bouts-of-standing-and-light-intensity-physical-activity-in-a-simulated-workplace-environment
#3
Sarah L Mullane, Matthew P Buman, Zachary S Zeigler, Noe C Crespo, Glenn A Gaesser
OBJECTIVES: To compare acute cognitive effects following bouts of standing (STAND), cycling (CYCLE) and walking (WALK) to a sit-only (SIT) condition. DESIGN: Randomized cross-over full-factorial study. METHODS: Nine overweight (BMI=29±3kg/m(2)) adults (30±15years; 7 females, 2 males) completed four conditions (SIT, STAND, WALK and CYCLE) across a 6h period with a 7days washout period between conditions. SIT consisted of uninterrupted sitting...
October 8, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27726029/feasibility-of-baseline-neurocognitive-assessment-using-cogstate-during-the-first-month-of-therapy-for-childhood-leukemia
#4
Stephen A Sands, Brian T Harel, Mirko Savone, Kara Kelly, Veena Vijayanathan, Jennifer Greene Welch, Lynda Vrooman, Lewis B Silverman, Peter D Cole
PURPOSE: Neurocognitive impairment is frequently observed among acute lymphoblastic leukemia (ALL) survivors within the domains of intelligence, attention, processing speed, working memory, learning, and memory. However, few have investigated treatment-induced changes in neurocognitive function during the first months of treatment. Additionally, dysfunction during treatment may be preceded by changes in biomarkers measured within cerebrospinal fluid (CSF). Identification of acute declines in neurocognitive function, as well as predictive genotypes or biomarkers, could guide therapeutic trials of protective interventions...
October 10, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27692987/neurocognitive-function-in-children-with-primary-hypertension
#5
Marc B Lande, Donald L Batisky, Juan C Kupferman, Joshua Samuels, Stephen R Hooper, Bonita Falkner, Shari R Waldstein, Peter G Szilagyi, Hongyue Wang, Jennifer Staskiewicz, Heather R Adams
OBJECTIVE: To compare neurocognitive test performance of children with primary hypertension with that of normotensive controls. STUDY DESIGN: Seventy-five children (10-18 years of age) with newly diagnosed, untreated hypertension and 75 frequency-matched normotensive controls had baseline neurocognitive testing as part of a prospective multicenter study of cognition in primary hypertension. Subjects completed tests of general intelligence, attention, memory, executive function, and processing speed...
September 27, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27690742/the-impact-of-administration-order-in-studies-of-computerized-neurocognitive-assessment-tools-ncats
#6
Wesley R Cole, Jacques P Arrieux, Elizabeth M Dennison, Brian J Ivins
Computerized neurocognitive assessment tools (NCATs) have become a common way to assess postconcussion symptoms. As there is increasing research directly comparing multiple NCATs to each other, it is important to consider the impact that order of test administration may have on the integrity of the results. This study investigates the impact of administration order in a study of four different NCATs; Automated Neuropsychological Assessment Metrics (ANAM4), CNS Vital Signs (CNS-VS), CogState, and Immediate Post-Concussion Assessment and Cognitive Test (ImPACT)...
October 3, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27613569/the-relationship-between-baseline-eeg-spectra-power-and-memory-performance-in-older-african-americans-endorsing-cognitive-concerns-in-a-community-setting
#7
Voyko Kavcic, Bojan Zalar, Bruno Giordani
The finding that some older individuals report declines in aspects of cognitive functioning is becoming a frequently used criteria to identify elderly at risk for mild cognitive impairment (MCI) and dementia. Once concerns are identified in a community setting, however, effective means are necessary to pinpoint those individuals who should go on to more complex and costly diagnostic evaluations (e.g., functional imaging). We tested 44 African American volunteers endorsing cognitive concerns (37 females, 7 males) age≥65years with CogState battery subtests and recorded resting-state EEG, with eyes closed...
November 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27589532/associations-between-performance-on%C3%A2-an%C3%A2-abbreviated-cogstate-battery-other%C3%A2-measures-of-cognitive-function-and%C3%A2-biomarkers-in-people-at-risk-for%C3%A2-alzheimer-s-disease
#8
Annie M Racine, Lindsay R Clark, Sara E Berman, Rebecca L Koscik, Kimberly D Mueller, Derek Norton, Christopher R Nicholas, Kaj Blennow, Henrik Zetterberg, Bruno Jedynak, Murat Bilgel, Cynthia M Carlsson, Bradley T Christian, Sanjay Asthana, Sterling C Johnson
It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer's disease(AD). In 469 late middle-aged participants from the Wisconsin Registry for Alzheimer's Prevention(mean age 63.8±7 years at testing; 67% female; 39% APOE4+), we examined relationships between a CogState abbreviated battery(CAB) of seven tests and demographic characteristics, traditional paper-based neuropsychological tests as well as a composite cognitive impairment index, cognitive impairment status(determined by consensus review), and biomarkers for amyloid and tau(CSF phosphorylated-tau/Aβ42 and global PET-PiB burden) and neural injury(CSF neurofilament light protein)...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27586003/performance-on-the-cogstate-brief-battery-is-related-to-amyloid-levels-and-hippocampal-volume-in-very-mild-dementia
#9
Yen Ying Lim, Victor L Villemagne, Simon M Laws, Robert H Pietrzak, David Ames, Christopher Fowler, Stephanie Rainey-Smith, Peter J Snyder, Pierrick Bourgeat, Ralph N Martins, Olivier Salvado, Christopher C Rowe, Colin L Masters, Paul Maruff
In a group of older adults with very mild dementia, we aimed to characterize the nature and magnitude of cognitive decline as measured by the Cogstate Brief Battery, in relation to Aβ levels and hippocampal volume. Participants were characterized according to their status on the Clinical Dementia Rating (CDR) scale. A total of 308 individuals who were CDR 0 and had low cerebral Aβ levels (Aβ-), 32 individuals who were Aβ- and CDR 0.5, and 43 individuals who were Aβ+ and CDR 0.5 were included in this study...
November 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27577965/embolic-protection-in-patients-undergoing-transaortic-transcatheter-aortic-valve-replacement-initial-experience-with-the-triguard-hdh-embolic-deflection-device
#10
Francisco Campelo-Parada, Ander Regueiro, Eric Dumont, Robert DeLarochellière, Jean-Michel Paradis, Siamak Mohammadi, Daniel Doyle, Josep Rodés-Cabau
BACKGROUND: Stroke remains one of the most worrisome complications following transcatheter aortic valve replacement (TAVR). This pilot study evaluates the safety, feasibility, and exploratory efficacy of the TriGuard HDH embolic deflection device (Keystone Heart Ltd., Caesarea, Israel) in patients undergoing transaortic TAVR. METHODS: A total of 10 patients (median age: 81 years, STS score: 9.6 ± 5.6%) undergoing transaortic TAVR were included. All 30-day events were recorded and defined according to Valve Academic Research Consortium-2 criteria...
October 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27540084/presence-of-cerebral-microbleeds-is-associated-with-worse-executive-function-in-pediatric-brain-tumor-survivors
#11
Erika Roddy, Katherine Sear, Erin Felton, Benita Tamrazi, Karen Gauvain, Joseph Torkildson, Benedict Del Buono, David Samuel, Daphne A Haas-Kogan, Josephine Chen, Robert E Goldsby, Anuradha Banerjee, Janine M Lupo, Annette M Molinaro, Heather J Fullerton, Sabine Mueller
BACKGROUND: A specific form of small-vessel vasculopathy-cerebral microbleeds (CMBs)-has been linked to various types of dementia in adults. We assessed the incidence of CMBs and their association with neurocognitive function in pediatric brain tumor survivors. METHODS: In a multi-institutional cohort of 149 pediatric brain tumor patients who received cranial radiation therapy (CRT) between 1987 and 2014 at age <21 years and 16 patients who did not receive CRT, we determined the presence of CMBs on brain MRIs...
November 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27516906/does-the-beck-cognitive-insight-scale-predict-response-to-cognitive-remediation-in-schizophrenia
#12
Audrey Benoit, Philippe-Olivier Harvey, Louis Bherer, Martin Lepage
Cognitive remediation therapy (CRT) has emerged as a viable treatment option for people diagnosed with schizophrenia presenting disabling cognitive deficits. However, it is important to determine which variables can influence response to CRT in order to provide cost-effective treatment. This study's aim was to explore cognitive insight as a potential predictor of cognitive improvement after CRT. Twenty patients with schizophrenia completed a 24-session CRT program involving 18 hours of computer exercises and 6 hours of group discussion to encourage generalization of cognitive training to everyday activities...
2016: Schizophrenia Research and Treatment
https://www.readbyqxmd.com/read/27484173/the-beneficial-effects-of-cognitive-training-with-simple-calculation-and-reading-aloud-in-an-elderly-postsurgical-population-study-protocol-for-a-randomized-controlled-trial
#13
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
BACKGROUND: This project proposes a pilot study to investigate the positive healing effects of cognitive training with simple arithmetic and reading aloud on elderly postsurgical patients. Elderly patients undergoing surgery have an increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery has aged...
2016: Trials
https://www.readbyqxmd.com/read/27467711/cognitive-physical-and-physiological-responses-of-school-boy-cricketers-to-a-30-over-batting-simulation
#14
David Goble, Candice Jo-Anne Christie
The purpose of this study was to assess how cognitive and physical performance are affected during a prolonged, fatigue-inducing cricket-batting simulation. Fifteen amateur batters from three Eastern Cape schools in South Africa were recruited (mean ± SD: age 17 ± 0.92 years; stature 1.75 ± 0.07 m; body mass 78.3 ± 13.2 kg). Participants completed a 6-stage, 30-over batting simulation (BATEX(©)). During the protocol, there were five periods of cognitive assessment (CogState brief test battery, Melbourne, Australia)...
July 28, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27325690/a-screening-strategy-for-hiv-associated-neurocognitive-disorders-that-accurately-identifies-patients-requiring-neurological-review
#15
Mark Bloch, Jody Kamminga, Avindra Jayewardene, Michael Bailey, Angela Carberry, Trina Vincent, Dick Quan, Paul Maruff, Bruce Brew, Lucette A Cysique
BACKGROUND: Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are not routinely assessed due to the lack of an adequate screening strategy. We aimed to develop a clinically relevant screening procedure for symptomatic HAND, validated against a gold standard neuropsychological (NP) test battery. METHODS: Representative HIV-infected (HIV+) and demographically matched HIV-uninfected (HIV-) participants in an observational study completed a standard evaluation for mood, drug and/or alcohol use, and activities of daily living and a newly designed 20-minute computerized CogState battery that assessed 5 cognitive domains...
September 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27266359/regular-cognitive-self-monitoring-in-community-dwelling-older-adults-using-an-internet-based-tool
#16
Elise G Valdes, Nasreen A Sadeq, Aryn L Harrison Bush, David Morgan, Ross Andel
INTRODUCTION: Monitoring for various health conditions (e.g., breast cancer, hypertension) has become common practice. However, there is still no established tool for regular monitoring of cognition. In this pilot longitudinal study, we examined the utility and feasibility of internet-based cognitive self-monitoring using data from the first 12 months of this ongoing study. METHOD: Cognitively healthy community-dwelling older adults (Montreal Cognitive Assessment ≥ 26) were enrolled on a rolling basis and were trained in self-administration of the internet-based version of the CogState Brief Battery...
November 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27245592/utility-of-a-brief-computerized-battery-to-assess-hiv-associated-neurocognitive-impairment-in-a-resource-limited-setting
#17
Nirupama Yechoor, Sheri L Towe, Kevin R Robertson, Daniel Westreich, Noeline Nakasujja, Christina S Meade
Despite the persistently high prevalence of neurocognitive impairment in HIV-positive patients, routine HIV care in many resource-limited settings does not include neuropsychological assessment. The objective of this study was to examine the utility of a brief computerized battery for identifying neurocognitive impairment in a busy HIV clinic in Uganda. Specifically, we compared performance on a gold standard neuropsychological exam to that on the CogState Brief Battery. In this cross-sectional study, 181 HIV-positive patients completed both assessment batteries in a randomized order...
December 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27125367/a-cross-sectional-study-to-evaluate-the-association-of-hyperbilirubinaemia-on-markers-of-cardiovascular-disease-neurocognitive-function-bone-mineral-density-and-renal-markers-in-hiv-1-infected-subjects-on-protease-inhibitors
#18
T J Barber, G Moyle, A Hill, G Jagjit Singh, A Scourfield, H M Yapa, L Waters, D Asboe, M Boffito, M Nelson
BACKGROUND: Ongoing inflammation in controlled HIV infection contributes to non-AIDS comorbidities. High bilirubin appears to exhibit an anti-inflammatory effect in vivo. We therefore examined whether increased bilirubin in persons with HIV was associated with differences in markers of inflammation and cardiovascular, bone, renal disease, and neurocognitive (NC) impairment. METHODS: This cross-sectional study examined inflammatory markers in individuals with stable HIV infection treated with two nucleoside reverse transcriptase inhibitors and a boosted protease inhibitor...
May 2016: HIV Clinical Trials
https://www.readbyqxmd.com/read/27085943/the-cognitive-impairments-and-psychological-wellbeing-of-methamphetamine-dependent-patients-compared-with-health-controls
#19
Na Zhong, Haifeng Jiang, Jiang Du, Yan Zhao, Haiming Sun, Ding Xu, Chuanwei Li, Wenxu Zhuang, Xu Li, Kenji Hashimoto, Min Zhao
BACKGROUND AND AIMS: Chronic methamphetamine (MA) use is associated with cognitive impairment and psychopathological symptoms. This longitudinal study aims to examine the cognitive function of MA addicts during periods of abstinence. METHODS: Fifty-four MA dependent individuals and 58 healthy controls (HC) completed the psychological wellbeing scales and the CogState Battery that evaluated seven cognitive domains. During approximately 6-month abstinence, the subjects completed the CogState battery twice at the interval of 3months...
August 1, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27045714/a-randomized-controlled-trial-to-evaluate-if-computerized-cognitive-rehabilitation-improves-neurocognition-in-ugandan-children-with-hiv
#20
Michael J Boivin, Noeline Nakasujja, Alla Sikorskii, Robert O Opoka, Bruno Giordani
OBJECTIVES: Clinically stable children with HIV can have neuromotor, attention, memory, visual-spatial, and executive function impairments. We evaluated neuropsychological and behavioral benefits of computerized cognitive rehabilitation training (CCRT) in Ugandan HIV children. DESIGN: One hundred fifty-nine rural Ugandan children with WHO Stage I or II HIV disease (6 to 12 years; 77 boys, 82 girls; M = 8.9, SD = 1.86 years) were randomized to one of three treatment arms over a 2-month period...
August 2016: AIDS Research and Human Retroviruses
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