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https://www.readbyqxmd.com/read/28444123/a-comparison-of-four-computerized-neurocognitive-assessment-tools%C3%A2-to-a-traditional-neuropsychological-test-battery-in-service-members-with-and-without-mild-traumatic-brain-injury
#1
Wesley R Cole, Jacques P Arrieux, Brian J Ivins, Karen A Schwab, Felicia M Qashu
Objective: Computerized neurocognitive assessment tools (NCATS) are often used as a screening tool to identify cognitive deficits after mild traumatic brain injury (mTBI). However, differing methodology across studies renders it difficult to identify a consensus regarding the validity of NCATs. Thus, studies where multiple NCATs are administered in the same sample using the same methodology are warranted. Method: We investigated the validity of four NCATs: the ANAM4, CNS-VS, CogState, and ImPACT...
April 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28413625/hiv-associated-neurocognitive-disorders-recent-advances-in-pathogenesis-biomarkers-and-treatment
#2
REVIEW
Antonia Carroll, Bruce Brew
HIV-associated neurocognitive disorders (HAND) remain prevalent despite plasma viral suppression by antiretroviral agents. In fact, the prevalence of milder subtypes of cognitive impairment is increasing. Neuropsychologic testing remains the "gold standard" of diagnosis; however, this is time consuming and costly in a resource-poor environment. Recently developed screening tools, such as CogState and the revised HIV dementia scale, have very good sensitivity and specificity in the more severe stages of HAND...
2017: F1000Research
https://www.readbyqxmd.com/read/28365750/correlation-between-the-cogstate-computerized-measure-and-wais-iv-among-birth-cohort-mothers
#3
Eeva-Leena Kataja, Linnea Karlsson, Mimmi Tolvanen, Christine Parsons, Adrian Schembri, Hanna Kiiski-Mäki, Hasse Karlsson
Objective: Large studies, with limited resources call for cost-effective cognitive assessment methods. Computerized tests offer viable alternatives but more data are needed on their functioning. Our aim was to evaluate the overlap between a computerized neuropsychological test battery and a traditional test of general intelligence (IQ). Method: Cognitive functioning was assessed in birth cohort mothers (n = 80) with two widely used methods: Cogstate, computerized test battery, and WAIS-IV, a traditional IQ test...
March 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28330458/the-effects-of-an-extensive-exercise-programme-on-the-progression-of-mild-cognitive-impairment-mci-study-protocol-for-a-randomised-controlled-trial
#4
Kate E Devenney, Brian Lawlor, Marcel G M Olde Rikkert, Stefan Schneider
BACKGROUND: Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by increasing cognitive reserve. There is also evidence of structural changes caused by exercise in preventing or delaying the genesis of neurodegeneration. Although initial studies indicate enhanced cognitive performance in patients with mild cognitive impairment (MCI) following an exercise intervention, little is known about the effect of an extensive, controlled and regular exercise regimen on the neuropathology of patients with MCI...
March 22, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28322606/cognitive-impairment-in-pediatric-onset-multiple-sclerosis-is-detected-by-the-brief-international-cognitive-assessment-for-multiple-sclerosis-and-computerized-cognitive-testing
#5
Leigh E Charvet, Michael Shaw, Ariana Frontario, Dawn Langdon, Lauren B Krupp
BACKGROUND: Cognitive impairment is a common and troubling feature of pediatric-onset multiple sclerosis (POMS). Brief cognitive assessment in the outpatient setting can identify and longitudinally monitor cognitive involvement so that early intervention is possible. OBJECTIVES: The goal of this study was to measure the sensitivity of two cognitive assessment approaches that are brief, repeatable, and suitable for clinical practice and for multicenter investigation...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28247479/does-efavirenz-replacement-improve-neurological-function-in-treated-hiv-infection
#6
B Payne, T J Chadwick, A Blamire, K N Anderson, J Parikh, J Qian, A M Hynes, J Wilkinson, D A Price
OBJECTIVES: The contribution of specific antiretroviral drugs to cognitive function in HIV-infected people remains poorly understood. Efavirenz (EFV) may plausibly cause cognitive impairment. The objective of this study was therefore to determine whether chronic EFV therapy is a modifier of neurocognitive and neurometabolic function in the setting of suppressive highly active antiretroviral therapy. METHODS: We performed an open-label phase IV controlled trial. Adult subjects who were stable on suppressive EFV therapy for at least 6 months were switched to ritonavir-boosted lopinavir (LPV/r) with no change in the nucleoside reverse transcriptase inhibitor (NRTI) backbone...
March 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28242871/attenuation-of-ketamine-induced-impairment-in-verbal-learning-and-memory-in-healthy-volunteers-by-the-ampa-receptor-potentiator-pf-04958242
#7
M Ranganathan, N DeMartinis, B Huguenel, F Gaudreault, M M Bednar, C L Shaffer, S Gupta, J Cahill, M A Sherif, J Mancuso, L Zumpano, D C D'Souza
There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity suggests that facilitation of NMDAR function might ameliorate CIAS. One strategy to correct NMDAR hypofunction is to stimulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) as AMPAR and NMDAR functioning are coupled and interdependent. In rats and nonhuman primates (NHP), AMPAR potentiators reduce spatial working memory deficits caused by the nonselective NMDAR antagonist ketamine...
February 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28225155/remotely-supervised-transcranial-direct-current-stimulation-increases-the-benefit-of-at-home-cognitive-training-in-multiple-sclerosis
#8
Leigh Charvet, Michael Shaw, Bryan Dobbs, Ariana Frontario, Kathleen Sherman, Marom Bikson, Abhishek Datta, Lauren Krupp, Esmail Zeinapour, Margaret Kasschau
OBJECTIVE: To explore the efficacy of remotely-supervised transcranial direct current stimulation (RS-tDCS) paired with cognitive training (CT) exercise in participants with multiple sclerosis (MS). METHODS: In a feasibility study of RS-tDCS in MS, participants completed ten sessions of tDCS paired with CT (1.5 mA × 20 min, dorsolateral prefrontal cortex montage). RS-tDCS participants were compared to a control group of adults with MS who underwent ten 20-min CT sessions through the same remotely supervised procedures...
February 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28081034/the-effects-of-the-removal-of-electronic-devices-for-48-hours-on-sleep-in-elite-judo-athletes
#9
Ian C Dunican, David T Martin, Shona L Halson, Reid Reale, Brian Dawson, John Caldwell, Maddison J Jones, Peter R Eastwood
OBJECTIVE: This study examined the effects of the removal of electronic devices (i.e., smartphones, etc.) for 48 hours on sleep quality and next-day athletic and cognitive performance in elite Judo athletes. PARTICIPANTS: Over 6 days and nights, 23 eliteAustralian Judo athletes were monitored while attending a camp at the Australian Institute of Sport (AIS). In 14 athletes all electronic devices were removed on days 3 & 4 (i.e. for 48 hours: the 'device-restricted group') while 9 were permitted to use their devices throughout the camp (the 'control group')...
January 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28080264/convergent-and-criterion-validity-of-the-cogstate-computerized-brief-battery-cognitive-assessment-in-women-with-and-without-breast-cancer
#10
Sunita K Patel, Adrienne M Meier, Nathaniel Fernandez, Tracy T Y Lo, Colleen Moore, Nicole Delgado
OBJECTIVE: Computerized tests have increasingly garnered interest for assessing cognitive functioning due to their potential logistical and financial advantages over traditional 'pencil and-paper' neuropsychological tests. However, psychometric information is necessary to guide decisions about their clinical and research utility with varied populations. We explored the convergent construct validity and criterion validity of the CogState computerized tests in breast cancer survivors, a group known to present with mostly mild, subtle cognitive dysfunction...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28072503/posttraumatic-stress-disorder-symptoms-and-cognitive-function-in-a-large-cohort-of-middle-aged-women
#11
Jennifer A Sumner, Kaitlin Hagan, Fran Grodstein, Andrea L Roberts, Brian Harel, Karestan C Koenen
BACKGROUND: Posttraumatic stress disorder (PTSD) has been linked to cognitive decline, but research in women is generally lacking. We examined whether trauma and elevated PTSD symptoms were associated with worse cognitive function in middle-aged civilian women. A secondary objective was to investigate the possible role of depression in the relation of PTSD symptoms to cognitive function. METHODS: The sample comprised 14,029 middle-aged women in the Nurses' Health Study II...
April 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28068147/do-wellness-tourists-get-well-an-observational-study-of-multiple-dimensions-of-health-and-well-being-after-a-week-long-retreat
#12
Marc M Cohen, Fiona Elliott, Liza Oates, Adrian Schembri, Nitin Mantri
BACKGROUND: Wellness retreats use many complementary and alternative therapies within a holistic residential setting, yet few studies have evaluated the effect of retreat experiences on multiple dimensions of health and well-being, and no published studies have reported health outcomes in wellness tourists. OBJECTIVES: To assess the effect of a week-long wellness-retreat experience in wellness tourists. DESIGN: A longitudinal observational study with outcomes assessed upon arrival and departure and 6 weeks after the retreat...
February 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28057452/stimulating-cognition-in-schizophrenia-a-controlled-pilot-study-of-the-effects-of-prefrontal-transcranial-direct-current-stimulation-upon-memory-and-learning
#13
Natasza D Orlov, Derek K Tracy, Daniel Joyce, Shinal Patel, Joanna Rodzinka-Pasko, Hayley Dolan, John Hodsoll, Tracy Collier, John Rothwell, Sukhwinder S Shergill
BACKGROUND: Schizophrenia is characterized by prominent cognitive deficits, impacting on memory and learning; these are strongly associated with the prefrontal cortex. OBJECTIVE/HYPOTHESIS: To combine two interventions, transcranial direct current stimulation (tDCS) over the prefrontal cortex and cognitive training, to examine change in cognitive performance in patients with schizophrenia. METHODS: A double blind, sham-controlled pilot study of 49 patients with schizophrenia, randomized into real or sham tDCS stimulation groups...
December 28, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/28052738/determining-optimal-impairment-rating-methodology-for-a-new-hiv-associated-neurocognitive-disorder-screening-procedure
#14
Jody Kamminga, Mark Bloch, Trina Vincent, Angela Carberry, Bruce J Brew, Lucette A Cysique
INTRODUCTION: The current study sought to determine the optimal impairment rating definition for a new HIV-associated neurocognitive disorder (HAND) screening procedure as compared to standard neuropsychological testing. METHOD: A total of 55 HIV-infected (HIV+; 19% AIDS; 87% on combination antiretroviral therapy, cART; 80% plasma undetectable) and 22 demographically comparable HIV-uninfected (HIV-) control adults (all male) enrolled in an urban Australian primary care cohort study completed the CogState computerized cognitive screen, a standard independence in activities of daily living (ADL) questionnaire, and a standard neuropsychological test battery...
January 4, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27987229/neuronal-damage-biomarkers-in-the-identification-of-patients-at-risk-of-long-term-postoperative-cognitive-dysfunction-after-cardiac-surgery
#15
W F Kok, J Koerts, O Tucha, T W L Scheeren, A R Absalom
Biomarkers of neurological injury can potentially predict postoperative cognitive dysfunction. We aimed to identify whether classical neuronal damage-specific biomarkers, including brain fatty acid-binding protein, neuron-specific enolase and S100 calcium-binding protein β, as well as plasma-free haemoglobin concentration as a measure of haemolysis, could be used to predict the risk of long-term cognitive decline after coronary artery bypass grafting with or without cardiopulmonary bypass. We assessed cognitive function using the CogState brief computerised cognitive test battery at 3 months and at 15 months after surgery...
December 17, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27852143/reliability-and-validity-of-the-cogstate-computerized-battery-in-patients-with-seizure-disorders-and-healthy-young-adults-comparison-with-standard-neuropsychological-tests
#16
Sara Fratti, Stephen C Bowden, Mark J Cook
OBJECTIVE: The aim was to examine the reliability and validity of two measures of learning and memory within the CogState Computerized Battery: the One Card Learning (OCL) and the Continuous Paired Associative Learning (CPAL). Comparison of various reliable change measures was also included to examine rate of correct cognitive change classification, in particular, when using the Within-Subject Standard Deviation (WSD). METHOD: The OCL and the CPAL tests were administered twice and compared to standard and experimental versions of conventional neuropsychological tests in patients with seizure disorders (Baseline n = 80, Follow-up = 54) and university students (Baseline n = 89, Follow-up n = 87)...
November 17, 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27785907/associations-between-cognitive-impairment-and-patient-reported-measures-of-physical-mental-functioning-in-older-people-living-with-hiv
#17
J Underwood, D De Francesco, F A Post, J H Vera, I Williams, M Boffito, P W Mallon, J Anderson, M Sachikonye, C Sabin, A Winston
OBJECTIVES: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. METHODS: We tested cognitive function using a computerized battery (CogState(™) ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 years participating in the Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study...
May 2017: HIV Medicine
https://www.readbyqxmd.com/read/27777038/acute-effects-on-cognitive-performance-following-bouts-of-standing-and-light-intensity-physical-activity-in-a-simulated-workplace-environment
#18
Sarah L Mullane, Matthew P Buman, Zachary S Zeigler, Noe C Crespo, Glenn A Gaesser
OBJECTIVES: To compare acute cognitive effects following bouts of standing (STAND), cycling (CYCLE) and walking (WALK) to a sit-only (SIT) condition. DESIGN: Randomized cross-over full-factorial study. METHODS: Nine overweight (BMI=29±3kg/m(2)) adults (30±15years; 7 females, 2 males) completed four conditions (SIT, STAND, WALK and CYCLE) across a 6h period with a 7days washout period between conditions. SIT consisted of uninterrupted sitting...
May 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27726029/feasibility-of-baseline-neurocognitive-assessment-using-cogstate-during-the-first-month-of-therapy-for-childhood-leukemia
#19
Stephen A Sands, Brian T Harel, Mirko Savone, Kara Kelly, Veena Vijayanathan, Jennifer Greene Welch, Lynda Vrooman, Lewis B Silverman, Peter D Cole
PURPOSE: Neurocognitive impairment is frequently observed among acute lymphoblastic leukemia (ALL) survivors within the domains of intelligence, attention, processing speed, working memory, learning, and memory. However, few have investigated treatment-induced changes in neurocognitive function during the first months of treatment. Additionally, dysfunction during treatment may be preceded by changes in biomarkers measured within cerebrospinal fluid (CSF). Identification of acute declines in neurocognitive function, as well as predictive genotypes or biomarkers, could guide therapeutic trials of protective interventions...
February 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27692987/neurocognitive-function-in-children-with-primary-hypertension
#20
Marc B Lande, Donald L Batisky, Juan C Kupferman, Joshua Samuels, Stephen R Hooper, Bonita Falkner, Shari R Waldstein, Peter G Szilagyi, Hongyue Wang, Jennifer Staskiewicz, Heather R Adams
OBJECTIVE: To compare neurocognitive test performance of children with primary hypertension with that of normotensive controls. STUDY DESIGN: Seventy-five children (10-18 years of age) with newly diagnosed, untreated hypertension and 75 frequency-matched normotensive controls had baseline neurocognitive testing as part of a prospective multicenter study of cognition in primary hypertension. Subjects completed tests of general intelligence, attention, memory, executive function, and processing speed...
January 2017: Journal of Pediatrics
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