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https://www.readbyqxmd.com/read/29771285/increased-dolutegravir-peak-concentrations-in-people-living-with-hiv-aged-60-and-over-and-analysis-of-sleep-quality-and-cognition
#1
Emilie R Elliot, Xinzhu Wang, Suveer Singh, Bryony Simmons, Jaime H Vera, Robert F Miller, Colin Fitzpatrick, Graeme Moyle, Myra McClure, Marta Boffito
Background: Demographic data show an increasingly aging HIV population worldwide. Recent concerns over dolutegravir-related neuropsychiatric toxicity have emerged, particularly amongst older HIV patients. We describe the pharmacokinetics (PK) of dolutegravir (DTG) 50mg once daily in people living with HIV (PLWH) aged 60 and older. Additionally, to address the call for prospective neuropsychiatric toxicodynamic data, we evaluate changes in sleep quality and cognitive function after switching to abacavir (ABC)/lamivudine (3TC)/DTG, over 6 months in this population...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29754989/the-brain-health-registry-an-internet-based-platform-for-recruitment-assessment-and-longitudinal-monitoring-of-participants-for-neuroscience-studies
#2
Michael W Weiner, Rachel Nosheny, Monica Camacho, Diana Truran-Sacrey, R Scott Mackin, Derek Flenniken, Aaron Ulbricht, Philip Insel, Shannon Finley, Juliet Fockler, Dallas Veitch
INTRODUCTION: Recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies and clinical trials limit the development of new treatments. Widespread Internet use allows data capture from participants in an unsupervised setting. The Brain Health Registry, a website and online registry, collects data from participants and their study partners. METHODS: The Brain Health Registry obtains self and study partner report questionnaires and neuropsychological data, including the Cogstate Brief Battery, Lumos Labs Neurocognitive Performance Test, and MemTrax Memory Test...
May 8, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29752016/perioperative-research-into-memory-prime-cognitive-impairment-following-a-severe-burn-injury-and-critical-care-admission-part-1
#3
Edward J R Watson, Klará Nenadlová, Olivia H Clancy, Mena Farag, Naz A Nordin, Agnes Nilsen, Ashley R T Mehmet, Ahmed Al-Hindawi, Sundhiya Mandalia, Lisa M Williams, Trudi L Edginton, Marcela P Vizcaychipi
INTRODUCTION: An investigation into long-term cognitive impairment and Quality of Life (QoL) after severe burns. METHODS: A proof of principle, cohort design, prospective, observational clinical study. Patients with severe burns (>15% TBSA) admitted to Burns ICU for invasive ventilation were recruited for psychocognitive assessment with a convenience sample of age and sex-matched controls. Participants completed psychological and QoL questionnaires, the Cogstate® electronic battery, Hopkins Verbal Learning, Verbal Fluency and Trail making tasks...
May 8, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29729687/exercise-effects-on-cognitive-functioning-in-young-adults-with-first-episode-psychosis-fitforlife
#4
Mats Hallgren, Maria Skott, Örjan Ekblom, Joseph Firth, Adrian Schembri, Yvonne Forsell
BACKGROUND: Exercise has mood-enhancing effects and can improve cognitive functioning, but the effects in first-episode psychosis (FEP) remain understudied. We examined the feasibility and cognitive effects of exercise in FEP. METHOD: Multi-center, open-label intervention study. Ninety-one outpatients with FEP (mean age = 30 years, 65% male) received usual care plus a 12-week supervised circuit-training program, consisting of high-volume resistance exercises, aerobic training, and stretching...
May 6, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29707036/effect-of-chlorogenic-acid-intake-on-cognitive-function-in-the-elderly-a-pilot-study
#5
Morimasa Kato, Ryuji Ochiai, Kazuya Kozuma, Hirotaka Sato, Yoshihisa Katsuragi
Objective: To evaluate the effect of chlorogenic acids (CGAs) intake on cognitive function. Methods: In this pilot study, the Cogstate and CNS Vital Signs test batteries were used to evaluate cognitive function in 8 healthy elderly men and women complaining of subjective memory loss after a 6-month intake of a test beverage containing 330 mg of CGAs just before bedtime. Results: After a 6-month CGA intake period, significant improvement was observed in the One Back Test of the Cogstate, the Shifting Attention Test, and Finger Tapping Test as well as in the composite memory, verbal memory, complex attention, cognitive flexibility, executive function, and motor speed domains of the CNS Vital Signs test battery...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29684091/impaired-visual-working-and-verbal-memory-in-first-episode-drug-naive-patients-with-major-depressive-disorder-in-a-chinese-population
#6
Ce Chen, Wen-Hui Jiang, Wei Wang, Xian-Cang Ma, Ye Li, Jin Wu, Kenji Hashimoto, Cheng-Ge Gao
Cognitive impairment has been observed in patients with major depressive disorder (MDD). However, it remains unclear whether the deficits in specific cognitive domains are present in first-episode, drug-naïve patients or medicated patients. In the present study, using the CogState battery (CSB) Chinese language version, we evaluated the visual, working, and verbal memory in first-episode drug-naive patients and medicated patients with MDD in a Chinese population. We measured the cognitive function in first-episode drug-naïve patients (n = 36), medicated MDD patients (n = 71), and age- and sex-matched healthy control subjects (n = 59) in a Chinese population...
2018: PloS One
https://www.readbyqxmd.com/read/29643802/the-beneficial-effects-of-cognitive-training-with-simple-calculation-and-reading-aloud-scra-in-the-elderly-postoperative-population-a-pilot-randomized-controlled-trial
#7
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
Background: There has been little research conducted regarding cognitive treatments for the elderly postsurgical population. Patients aged ≥60 years have an increased risk of postoperative cognitive decline, a condition in which cognitive functions are negatively affected. This cognitive decline can lead to a decline in quality of life. In order to maintain a high quality of life, the elderly postsurgical population may benefit from treatment to maintain and/or improve their cognitive functions. This pilot study investigates the effect of simple calculation and reading aloud (SCRA) cognitive training in elderly Japanese postsurgical patients...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29589170/computerized-tests-to-evaluate-recovery-of-cognitive-function-after-deep-sedation-with-propofol-and-remifentanil-for-colonoscopy
#8
Xavier Borrat, Marta Ubre, Raquel Risco, Pedro L Gambús, Angela Pedroso, Aina Iglesias, Gloria Fernandez-Esparrach, Àngels Ginés, Jaume Balust, Graciela Martínez-Palli
The use of sedation for diagnostic procedures including gastrointestinal endoscopy is rapidly growing. Recovery of cognitive function after sedation is important because it would be important for most patients to resume safe, normal life soon after the procedure. Computerized tests have shown being accurate descriptors of cognitive function. The purpose of the present study was to evaluate the time course of cognitive function recovery after sedation with propofol and remifentanil. A prospective observational double blind clinical study conducted in 34 young healthy adults undergoing elective outpatient colonoscopy under sedation with the combination of propofol and remifentanil using a target controlled infusion system...
March 27, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29572188/long-term-cognitive-outcomes-in-male-and-female-athletes-following-sport-related-concussions
#9
Veronik Sicard, Robert Davis Moore, Dave Ellemberg
Despite concussion being a serious public health concern and the increasing participation of female athletes in sport, the comparative long-term outcomes of male and female athletes are poorly understood, potentially limiting the scientific understanding and clinical management of these injuries. We examined whether sex influences the long-term cognitive outcomes in athletes with a history of concussion (HOC; 6+ months from injury). Accordingly, 196 asymptomatic student-athletes participated in the study (98 with a HOC; 98 matched controls)...
March 20, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29522863/neuropsychological-benefits-of-computerized-cognitive-rehabilitation-training-in-ugandan-children-surviving-severe-malaria-a-randomized-controlled-trial
#10
Michael J Boivin, Noeline Nakasujja, Alla Sikorskii, Horacio Ruiseñor-Escudero, Itziar Familiar-Lopez, Kimberley Walhof, Esther M van der Lugt, Robert O Opoka, Bruno Giordani
BACKGROUND: Computerized cognitive rehabilitation training (CCRT) may be beneficial for alleviating persisting neurocognitive deficits in Ugandan severe malaria survivors. We completed a randomized controlled trial of CCRT for both severe malaria and non-malaria cohorts of children. METHODS: 150 school-age severe malaria and 150 non-malaria children were randomized to three treatment arms: 24 sessions of Captain's Log CCRT for attention, working memory and nonverbal reasoning, in which training on each of 9 tasks difficulty increased with proficiency; a limited CCRT arm that did not titrate to proficiency but randomly cycled across the simplest to moderate level of training; and a passive control arm...
March 6, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29510925/similar-psychotic-and-cognitive-profile-between-ketamine-dependence-with-persistent-psychosis-and-schizophrenia
#11
Wan-Ju Cheng, Chun-Hsin Chen, Chih-Ken Chen, Ming-Chyi Huang, Robert H Pietrzak, John H Krystal, Ke Xu
BACKGROUND: Ketamine has been used to probe the biology of psychosis and cognitive dysfunction in humans. High levels of ketamine abuse are associated with persisting psychosis (KPP) in a minority of users. However, relatively little is known about cognitive function among KPP patients and whether the cognitive impairments associated with KPP resemble those of schizophrenia (SZ). METHODS: We recruited 149 treatment-seeking patients, including nonpsychotic ketamine users (KNP, n=51), KPP (n=23), and SZ (n=75) patients...
March 3, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29461270/the-role-of-personality-in-a-regular-cognitive-monitoring-program
#12
Nasreen A Sadeq, Elise G Valdes, Aryn L Harrison Bush, Ross Andel
OBJECTIVES: This study examines the role of personality in cognitive performance, adherence, and satisfaction with regular cognitive self-monitoring. MATERIALS AND METHODS: One hundred fifty-seven cognitively healthy older adults, age 55+, completed the 44-item Big-Five Inventory and were subsequently engaged in online monthly cognitive monitoring using the Cogstate Brief Battery for up to 35 months (M=14 mo, SD=7 mo). The test measures speed and accuracy in reaction time, visual learning, and working memory tasks...
February 20, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29392371/effect-of-intranasal-esketamine-on-cognitive-functioning-in-healthy-participants-a-randomized-double-blind-placebo-controlled-study
#13
Randall L Morrison, Maggie Fedgchin, Jaskaran Singh, Joop Van Gerven, Rob Zuiker, Kyoung Soo Lim, Peter van der Ark, Ewa Wajs, Liwen Xi, Peter Zannikos, Wayne C Drevets
BACKGROUND: The effect of intranasal esketamine on cognitive functioning in healthy participants is assessed in this study. METHODS: Twenty-four participants (19-49 years) were randomized to one of two treatment sequences in which either esketamine 84 mg or placebo was intranasally administered in a double-blind, two-period crossover design. Primary measures included five tests of Cogstate® computerized test battery assessed at 1 h predose and 40 min, 2, 4, and 6 h postdose...
April 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29280108/csf-inflammatory-markers-and-neurocognitive-function-after-addition-of-maraviroc-to-monotherapy-darunavir-ritonavir-in-stable-hiv-patients-the-cinammon-study
#14
T J Barber, A Imaz, M Boffito, J Niubó, A Pozniak, R Fortuny, J Alonso, N Davies, S Mandalia, D Podzamczer, B Gazzard
CINAMMON is a phase IV, open-label, single-arm, pilot study assessing maraviroc (MVC) in the central nervous system (CNS) when added to darunavir/ritonavir monotherapy (DRV/r) in virologically suppressed HIV-infected subjects. CCR5 tropic participants on DRV/r were recruited. Participants remained on DRV/r for 12 week (w) (control phase). MVC 150 mg qd was added w12-w36 (intervention phase). Lumbar puncture (LP) and neurocognitive function (Cogstate) examinations scheduled at baseline, w12 and w36; MRI before w12, again at w36...
February 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29277553/water-intake-reverses-dehydration-associated-impaired-executive-function-in-healthy-young-women
#15
Nina S Stachenfeld, Cheryl A Leone, Ellen S Mitchell, Eric Freese, Laura Harkness
INTRODUCTION: Healthy women do not always consume Recommended Daily Levels of fluid intake ad libitum. We hypothesized that 1) women lose≥1.0% BW during daily activities, 2) that mild body water loss impairs memory and executive function, 3) water intake to recommended daily levels will improve cognitive function. METHODS: We tested 12 women (26±5yr, 22.5±2.6kg/m2 BMI). Session 1 was a control (CON) session, during which subjects monitored their food and fluid intake (diary) and activity (Fitbit®)...
March 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29259553/indication-of-cognitive-change-and-associated-risk-factor-after-thoracic-surgery-in-the-elderly-a-pilot-study
#16
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery is aging. Methods: Cognitive function was measured for all subjects ( n = 12) before and after surgery using three different cognitive tests: Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), and a computerized Cogstate Brief Battery (CBB)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29188853/computerized-cognitive-testing-for-use-in-clinical-trials-a-comparison-of-the-nih-toolbox-and-cogstate-c3-batteries
#17
R F Buckley, K P Sparks, K V Papp, M Dekhtyar, C Martin, S Burnham, R A Sperling, D M Rentz
BACKGROUND: As prevention trials for Alzheimer's disease move into asymptomatic populations, identifying older individuals who manifest the earliest cognitive signs of Alzheimer's disease is critical. Computerized cognitive testing has the potential to replace current gold standard paper and pencil measures and may be a more efficient means of assessing cognition. However, more empirical evidence about the comparability of novel computerized batteries to paper and pencil measures is required...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29081720/effects-of-recent-alcohol-consumption-level-on-neurocognitive-performance-in-hiv-individuals
#18
Kara R Douglas-Newman, Rachel V Smith, Mary V Spiers, Timothy Pond, Henry R Kranzler
OBJECTIVES: Although HIV+ individuals may be at increased risk of alcohol-related cognitive impairment, the relations between drinking level and cognitive performance in these individuals are not well understood. We examined whether higher levels of recent drinking in HIV+ individuals were associated with poorer cognitive performance, particularly in executive functioning (EF) and memory. METHODS: We administered a comprehensive cognitive battery to 120 seropositive subjects (101 men) who reported alcohol consumption in the preceding 90 days...
September 2017: Addictive Disorders & Their Treatment
https://www.readbyqxmd.com/read/29069110/vortioxetine-for-major-depressive-disorder-vasomotor-and-cognitive-symptoms-associated-with-the-menopausal-transition
#19
Marlene P Freeman, Laura J Cheng, Danna Moustafa, Abigail Davies, Alexandra Z Sosinsky, Betty Wang, Laura F Petrillo, Charlotte Hogan, Lee S Cohen
BACKGROUND: In a preliminary trial, we assessed the efficacy of vortioxetine for major depressive disorder (MDD) during the menopausal transition. Secondary outcomes included hot flashes (HFs), anxiety, and cognitive complaints. METHODS: Perimenopausal and early postmenopausal women with MDD (N = 27) received 8 weeks of open-label, flexible-dose treatment with vortioxetine. The Montgomery-Åsberg Depression Rating Scale (MADRS) was the primary outcome measure. Secondary measures included: HF frequency, the Greene Climacteric Scale (GCS), Menopause-Specific Quality of Life Questionnaire (MEN-QOL), Beck Anxiety Inventory (BAI), Cognitive and Physical Functioning Questionnaire (CPFQ), Digit Symbol Substitution Test (DSST), and Cogstate testing...
November 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29023272/sensitivity-of-the-cogstate-test-battery-for-detecting-prolonged-cognitive-alterations-stemming-from-sport-related-concussions
#20
Veronik Sicard, Robert D Moore, Dave Ellemberg
OBJECTIVE: To determine if the Cogstate test battery contains the requisite sensitivity to detect prolonged cognitive alterations. METHODS: One hundred twenty collegiate athletes (71 with a history of concussion; 49 controls) completed the Cogstate test battery, to which we added a 2-back condition. In addition to the Cogstate clinical (transformed variables), we analyzed the raw data. RESULTS: The clinical variables failed to reveal any group differences...
October 5, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
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