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L-ornithine L-aspartate

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https://www.readbyqxmd.com/read/27696676/severity-of-experimental-traumatic-brain-injury-modulates-changes-in-concentrations-of-cerebral-free-amino-acids
#1
Angela Maria Amorini, Giacomo Lazzarino, Valentina Di Pietro, Stefano Signoretti, Giuseppe Lazzarino, Antonio Belli, Barbara Tavazzi
In this study, concentrations of free amino acids (FAA) and amino group containing compounds (AGCC) following graded diffuse traumatic brain injury (mild TBI, mTBI; severe TBI, sTBI) were evaluated. After 6, 12, 24, 48 and 120 hr aspartate (Asp), glutamate (Glu), asparagine (Asn), serine (Ser), glutamine (Gln), histidine (His), glycine (Gly), threonine (Thr), citrulline (Cit), arginine (Arg), alanine (Ala), taurine (Tau), γ-aminobutyrate (GABA), tyrosine (Tyr), S-adenosylhomocysteine (SAH), l-cystathionine (l-Cystat), valine (Val), methionine (Met), tryptophane (Trp), phenylalanine (Phe), isoleucine (Ile), leucine (Leu), ornithine (Orn), lysine (Lys), plus N-acetylaspartate (NAA) were determined in whole brain extracts (n = 6 rats at each time for both TBI levels)...
October 3, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27508354/rhizobial-strains-exert-a-major-effect-on-the-amino-acid-composition-of-alfalfa-nodules-under-nacl-stress
#2
Annick Bertrand, Marie Bipfubusa, Catherine Dhont, François-P Chalifour, Pascal Drouin, Chantal J Beauchamp
Specific amino acids have protective functions in plants under stress conditions. This study assessed the effects of rhizobial strains on the amino acid composition in alfalfa under salt stress. Two alfalfa cultivars (Medicago sativa L. cv Apica and salt-tolerant cv Halo) in association with two Sinorhizobium meliloti strains with contrasting growth under salt stress (strain A2 and salt-tolerant strain Rm1521) were exposed to different levels of NaCl (0, 20, 40, 80 or 160 mM NaCl) under controlled conditions...
August 3, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27488112/a-longitudinal-study-of-patients-with-cirrhosis-treated-with-l-ornithine-l-aspartate-examined-with-magnetization-transfer-diffusion-weighted-imaging-and-magnetic-resonance-spectroscopy
#3
Vijay P B Grover, Mark J W McPhail, Marzena Wylezinska-Arridge, Mary M E Crossey, Julie A Fitzpatrick, Louise Southern, Brian K Saxby, Nicola A Cook, I Jane Cox, Adam D Waldman, Novraj S Dhanjal, Aluel Bak-Bol, Roger Williams, Marsha Y Morgan, Simon D Taylor-Robinson
The presence of overt hepatic encephalopathy (HE) is associated with structural, metabolic and functional changes in the brain discernible by use of a variety of magnetic resonance (MR) techniques. The changes in patients with minimal HE are less well documented. Twenty-two patients with well-compensated cirrhosis, seven of whom had minimal HE, were examined with cerebral 3 Tesla MR techniques, including T1- and T2-weighted, magnetization transfer and diffusion-weighted imaging and proton magnetic resonance spectroscopy sequences...
August 3, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27330882/tissue-specific-regulation-of-potassium-homeostasis-by-high-doses-of-cationic-amino-acids
#4
Asunción Cremades, Jesús Del Rio-Garcia, Ana Lambertos, Carlos López-Garcia, Rafael Peñafiel
The administration of l-arginine hydrochloride has been used for testing pituitary secretion in humans, and as an experimental model for induction of acute pancreatitis in rats and mice. Whereas in the first case, the administration of the amino acid is associated with hiperkalemia, in the model of acute pancreatitis no data are available on possible changes in potassium homeostasis. The present study shows that the acute administration to mice of l-arginine hydrochloride or other cationic amino acids almost duplicate plasma potassium levels...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27300701/low-protein-formula-consequences-of-quantitative-effects-of-pre-analytical-factors-on-amino-acid-concentrations-in-plasma-of-healthy-infants
#5
Claude Bachmann, Alexander Kainz, Elisabeth Haschke-Becher
OBJECTIVE: Quantifying pre-analytical effects of postprandial sampling delay and daily protein intake on plasma amino acid concentrations in healthy infants fed formula with low protein content (1.8-1.9 g/100 kcal). Intake of formula with higher protein content bears a risk for later obesity (Kirchberg, J Clin Endocrinol Metab 100(1):149-158, 2015). Formulas containing less than 1.8 g protein might be adequate but not safe (Fomon, J Pediatr Gastroenterol Nutr 28:495-501, 1999). With on-demand feeding reproducible controls of indispensible amino acid concentration cannot be made at trough level...
June 15, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27215558/improving-long-term-outcomes-in-urea-cycle-disorders-report-from-the-urea-cycle-disorders-consortium
#6
Susan E Waisbren, Andrea L Gropman, Mark L Batshaw
The Urea Cycle Disorders Consortium (UCDC) has conducted, beginning in 2006, a longitudinal study (LS) of eight enzyme deficiencies/transporter defects associated with the urea cycle. These include N-acetylglutamate synthase deficiency (NAGSD); Carbamyl phosphate synthetase 1 deficiency (CPS1D); Ornithine transcarbamylase deficiency (OTCD); Argininosuccinate synthetase deficiency (ASSD) (Citrullinemia); Argininosuccinate lyase deficiency (ASLD) (Argininosuccinic aciduria); Arginase deficiency (ARGD, Argininemia); Hyperornithinemia, hyperammonemia, homocitrullinuria (HHH) syndrome (or mitochondrial ornithine transporter 1 deficiency [ORNT1D]); and Citrullinemia type II (mitochondrial aspartate/glutamate carrier deficiency [CITRIN])...
July 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27193025/vigilance-and-wake-eeg-architecture-in-simulated-hyperammonaemia-a-pilot-study-on-the-effects-of-l-ornithine-l-aspartate-lola-and-caffeine
#7
Maria Garrido, Jelena Skorucak, Daniela Raduazzo, Matteo Turco, Giuseppe Spinelli, Paolo Angeli, Piero Amodio, Peter Achermann, Sara Montagnese
UNLABELLED: Hyperammonaemia/mild hepatic encephalopathy (HE) can be simulated by the oral administration of a so-called amino acid challenge (AAC). This study sought to assess the effects of the AAC alone and in combination with either ammonia-lowering [L-ornithine-L-aspartate (LOLA)] or vigilance-enhancing medication (caffeine). Six patients with cirrhosis (5 males; 61.3 ± 9.2 years; 5 Child A, 1 Child B) and six healthy volunteers (5 males; 49.8 ± 10.6 years) were studied between 08:00 and 19:00 on Monday of three consecutive weeks...
August 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27126795/effects-of-down-regulating-ornithine-decarboxylase-upon-putrescine-associated-metabolism-and-growth-in-nicotiana-tabacum-l
#8
Heidi L Dalton, Cecilia K Blomstedt, Alan D Neale, Ros Gleadow, Kathleen D DeBoer, John D Hamill
Transgenic plants of Nicotiana tabacum L. homozygous for an RNAi construct designed to silence ornithine decarboxylase (ODC) had significantly lower concentrations of nicotine and nornicotine, but significantly higher concentrations of anatabine, compared with vector-only controls. Silencing of ODC also led to significantly reduced concentrations of polyamines (putrescine, spermidine and spermine), tyramine and phenolamides (caffeoylputrescine and dicaffeoylspermidine) with concomitant increases in concentrations of amino acids ornithine, arginine, aspartate, glutamate and glutamine...
May 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/26726023/hyperammonemic-hepatic-encephalopathy-management-through-l-ornithin-l-aspartate-administration-in-dogs
#9
Jin-Ok Ahn, Qiang Li, Young-Heun Lee, Sei-Myoung Han, Cheol-Yong Hwang, Hwa-Young Youn, Jin-Young Chung
Seventeen dogs were treated with L-ornithin-L-aspartate (LOLA; experimental group). Three dogs were treated with lactulose recognized therapy (control group). Following LOLA administration, 15 dogs experienced a significant decrease in ammonia level (p < 0.05) and showed clinical signs of improvement. However, there were no clinical signs of improvement in two dogs, even though the ammonia level decreased. Conversely, the clinical signs of the control group also improved and the ammonia level decreased, although these changes were not significant (p > 0...
September 30, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/26426168/effect-of-l-ornithine-l-aspartate-on-liver-injury-due-to-acute-ethyl-alcohol-intoxication-in-rats
#10
H M Durgun, A Ozhasenekler, R Dursun, M K Basarali, G Turkcu, M Orak, M Ustundag, C Guloglu
OBJECTIVE: Ethyl alcohol is a substance that is widely used worldwide and known to exert toxic effects on liver. In this study, we aimed to examine the effect of L-ornithine L-aspartate (LOLA) on the toxicity of a single dose of ethyl alcohol in rats. SUBJECTS AND METHOD: We used 32 randomly selected male Sprague-Dawley rats weighing 200-250 g. The rats were grouped into four groups with each group containing eight rats: Group 1: the control group, Group 2: the ethyl alcohol group, Group 3: the LOLA group and Group 4: the ethyl alcohol+LOLA group...
June 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/26364405/-options-in-the-treatment-of-hepatic-encephalopathy
#11
Karl-Uwe Petersen
Hepatic encephalopathy is a result of insufficient liver function, with grave consequences for the patients. It is primarily caused by disturbed hepatic elimination of the neurotoxin, ammonia (NH3). Aside from dietetic measures, treatment rests on drugs designed to reduce the NH3 burden. The primary options, lactulose and the practically unabsorbable antibiotic rifaximin are suitable to decrease the bacterial NH3 generation in the intestine. Other antibiotics like neomycin at best have a place in acute treatment...
May 2015: Medizinische Monatsschrift Für Pharmazeuten
https://www.readbyqxmd.com/read/26195203/should-we-treat-minimal-covert-hepatic-encephalopathy-and-with-what
#12
REVIEW
Phillip K Henderson, Jorge L Herrera
Hepatic encephalopathy exists along a continuum from abnormal neuropsychiatric testing in the absence of clinical findings to varying degrees of detectable clinical findings. The International Society for Hepatic Encephalopathy and Nitrogen Metabolism has endorsed the term "covert" to encompass minimal hepatic encephalopathy and grade I overt hepatic encephalopathy. Covert hepatic encephalopathy has been associated with poor quality of life, decreased employment, increased falls, and increased traffic accidents that significantly impact quality of life and health care expenditures...
August 2015: Clinics in Liver Disease
https://www.readbyqxmd.com/read/26164219/covert-and-overt-hepatic-encephalopathy-diagnosis-and-management
#13
REVIEW
Kavish R Patidar, Jasmohan S Bajaj
Hepatic encephalopathy (HE) is part of a spectrum of neurocognitive changes in cirrhosis. HE is divided into 2 broad categories based on severity: covert hepatic encephalopathy (CHE) and overt hepatic encephalopathy (OHE). CHE has a significant impact on a patient's quality of life, driving performance, and recently has been associated with increased hospitalizations and death. Likewise, OHE is associated with increased rates of hospitalizations and mortality, and poor quality of life. Given its significant burden on patients, care takers, and the health care system, early diagnosis and management are imperative...
November 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26041964/management-of-overt-hepatic-encephalopathy
#14
REVIEW
Praveen Sharma, Barjesh C Sharma
Hepatic encephalopathy (HE) is an important complication of cirrhosis with significant morbidity and mortality. Management of HE primarily involves avoidance of precipitating factors and administration of various ammonia-lowering therapies such as non-absorbable disaccharides, antimicrobial agents like rifaximin and l-ornithine l-aspartate. The non-absorbable disaccharides which include lactulose and lactitol are considered the first-line therapy for the treatment of HE and in primary and secondary prophylaxis of HE...
March 2015: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/26041963/management-of-covert-hepatic-encephalopathy
#15
REVIEW
Abhijeet Waghray, Nisheet Waghray, Kevin Mullen
Hepatic encephalopathy is a reversible progressive neuropsychiatric disorder that encompasses a wide clinical spectrum. Covert hepatic encephalopathy is defined as patients with minimal hepatic encephalopathy and Grade I encephalopathy by West-Haven Criteria. Terminology such as "sub-clinical", "latent", and "minimal" appear to trivialize the disease and have been replaced by the term covert. The lack of clinical signs means that covert hepatic encephalopathy is rarely recognized or treated outside of clinical trials with options for therapy based on patients with episodic hepatic encephalopathy...
March 2015: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/25740002/poly-ornithine-co-arginine-co-glycine-co-aspartic-acid-preparation-via-nca-polymerization-and-its-potential-as-a-polymeric-tumor-penetrating-agent
#16
Haiyang Yu, Zhaohui Tang, Dawei Zhang, Wantong Song, Taicheng Duan, Jingkai Gu, Xuesi Chen
A novel random copolypeptide of ornithine, arginine, glycine, and aspartic acid [Poly(ornithine-co-arginine-co-glycine-co-aspartic acid), Poly(O,R,G,D)] has been prepared through ring-opening polymerization of N-δ-carbobenzoxy-l-ornithine N-carboxyanhydride [Orn(Cbz)-NCA)], l-glycine N-carboxyanhydride (Gly-NCA) and β-benzyl l-aspartate N-carboxyanhydride [Asp(Bn)-NCA], following by subsequent deprotection and guanidization. The structure of Poly(O,R,G,D) was confirmed by nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC)...
June 2015: Macromolecular Bioscience
https://www.readbyqxmd.com/read/25684317/systematic-review-with-network-meta-analysis-the-comparative-effectiveness-and-safety-of-interventions-in-patients-with-overt-hepatic-encephalopathy
#17
REVIEW
G-Q Zhu, K-Q Shi, S Huang, L-R Wang, Y-Q Lin, G-Q Huang, Y-P Chen, M Braddock, M-H Zheng
BACKGROUND: Interventional treatment for overt hepatic encephalopathy (OHE), includes non-absorbable disaccharides, neomycin, rifaximin, L-ornithine-L-aspartate and branched chain amino acids (BCAA). However, the optimum regimen remains inconclusive. AIM: To compare interventions in terms of patients' adverse events and major clinical outcomes. METHODS: Literature search of PubMed, Embase, Scopus, and Cochrane Library studies published up to July 31 2014...
April 2015: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25528831/-pathogenesis-diagnosis-and-treatment-of-hepatic-encephalopathies-in-patients-with-liver-cirrhosis
#18
V O Moĭseienko, E H Manzhaliĭ, O S Solonovych, T D Nykula
The data on the positive experience with hepatic encephalopathy in patients with cirrhosis liver L-ornithine-L-aspartate (drug larnamyn), the effectiveness of which is provided by its components (amino acids, ornithine and aspartate) which improve metabolism, ammonia detoxification mechanism, production of energy in the Krebs cycle, promote restoration of the cell membrane, and carried out anti-inflammatory and detoxicative effect.
November 2014: Likars'ka Sprava
https://www.readbyqxmd.com/read/25448937/density-functional-theory-dft-and-natural-bond-orbital-nbo-study-of-vibrational-spectra-and-intramolecular-hydrogen-bond-interaction-of-l-ornithine-l-aspartate
#19
Linwei Li, Chengjun Wu, Zhiqiang Wang, Lixia Zhao, Zhen Li, Changshan Sun, Tiemin Sun
In this study, exhaustive conformations of (S)-4-amino-4-carboxybutan-1-aminium (S)-3-amino-3-carboxypropanoate (LOLA) have been scanned. Experimental and theoretical studies on the structure and vibrations of the title compound are presented. The optimized molecular structure, vibrational wavenumbers, Mulliken atomic charges, natural bond orbital (NBO) and molecular electrostatic potential studies have been performed by density functional theory (DFT) using B3LYP method with the 6-311++G(d,p) basis set. Computed X-ray powder diffraction (XRPD) data has been carried out by DFT calculations and ab initio from measured XRPD finding...
February 5, 2015: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/25381904/hepatic-encephalopathy-cause-and-possible-management-with-botanicals
#20
Suyash Tripathi, Yamini B Tripathi
Hepatic encephalopathy is a brain functional disorder, characterized by neuropsychiatric abnormalities with liver failure. High blood ammonia, causing glutamate neurotoxicity is the basic cause, finally leading to low-grade cerebral edema. Its manifestation is more likely in patients of sepsis, oxidative stress, generalized inflammation, gut mal-functioning, amoebiaesis, viral hepatitis, nervous imbalance, etc. Thus, the therapeutic goals primarily include the maintenance of proper blood supply and prevention of hypoxic condition in liver, along with management of factors responsible for high blood ammonia, oxidative stress, inflammation, and high GI- serotonin...
2014: Recent Patents on Inflammation & Allergy Drug Discovery
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