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https://www.readbyqxmd.com/read/28444939/continuous-ambulatory-peritoneal-dialysis-ascitic-and-pleural-body-fluids-evaluation-with-the-mindray-bc-6800-hematology-analyzer
#1
Oscar Fuster, Belinda Andino, Amparo Pardo, Begoña Laiz
BACKGROUND: Accurate evaluation of hematology analyzers is recommended before these devices can be broadly introduced for the routine testing of continuous ambulatory peritoneal dialysis (CAPD), ascitic, and pleural fluids. METHODS: We evaluated the performance of Mindray BC-6800 for white blood cell (WBC) and differential cell count in 50 CAPD, 60 ascitic and 40 pleural compared with manual microscopy. Within-run precision, limit of blank (LoB), limit of detection (LoD), limit of quantitation (LoQ), and carryover were assessed...
April 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28440336/ultrahigh-energy-density-harvested-from-domain-engineered-relaxor-ferroelectric-single-crystals-under-high-strain-rate-loading
#2
Sergey I Shkuratov, Jason Baird, Vladimir G Antipov, Evgueni F Talantsev, Jay B Chase, Wesley Hackenberger, Jun Luo, Hwan R Jo, Christopher S Lynch
Relaxor ferroelectric single crystals have triggered revolution in electromechanical systems due to their superior piezoelectric properties. Here the results are reported on experimental studies of energy harvested from (1-y-x)Pb(In1/2Nb1/2)O3-(y)Pb(Mg1/3Nb2/3)O3-(x)PbTiO3 (PIN-PMN-PT) crystals under high strain rate loading. Precise control of ferroelectric properties through composition, size and crystallographic orientation of domains made it possible to identify single crystals that release up to three times more electric charge density than that produced by PbZr0...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28434729/effects-of-intrauterine-infusion-of-escherichia-coli-lipopolysaccharide-on-uterine-mrna-gene-expression-and-peripheral-polymorphonuclear-leukocytes-in-jersey-cows-diagnosed-with-purulent-vaginal-discharge
#3
João G N Moraes, Luís G D Mendonça, Paula R B Silva, Alexandre A Scanavez, Klibs N Galvão, Michael A Ballou, Milli Worku, Ricardo C Chebel
The objectives of the current experiment were to investigate the effects of intrauterine treatment of cows with purulent vaginal discharge (PVD) using lipopolysaccharide (LPS) from Escherichia coli on uterine mRNA expression of genes related to inflammatory responses, peripheral polymorphonuclear leukocyte (PMN) function, hematological parameters, and blood concentrations of cortisol, haptoglobin, and progesterone (P4). Jersey cows (n = 3,084) were examined for PVD at 35 ± 6 d postpartum using the Metricheck device (Simcro, Hamilton, New Zealand)...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28433347/phonological-and-semantic-processing-during-comprehension-in-wernicke-s-aphasia-an-n400-and-phonological-mapping-negativity-study
#4
Holly Robson, Emma Pilkington, Louise Evans, Vincent Deluca, James L Keidel
Comprehension impairments in Wernicke's aphasia are thought to result from a combination of impaired phonological and semantic processes. However, the relationship between these cognitive processes and language comprehension has only been inferred through offline neuropsychological tasks. This study used ERPs to investigate phonological and semantic processing during online single word comprehension. EEG was recorded in a group of Wernicke's aphasia n=8 and control participants n=10 while performing a word-picture verification task...
April 19, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28431414/intratracheal-instillation-of-neutrophils-rescues-bacterial-overgrowth-initiated-by-trauma-damage-associated-molecular-patterns
#5
Kiyoshi Itagaki, Ingred Riça, Jing Zhang, Dave Gallo, Melissa DePrato, Leo E Otterbein, Carl J Hauser
BACKGROUND: Nosocomial pneumonias are common in trauma patients and so interventions to prevent and treat nosocomial pneumonia may improve outcomes. Our prior work strongly suggests that tissue injury predisposes to infections like nosocomial pneumonia because mitochondrial debris originating from injured cells contains damage-associated molecular patterns that can reduce neutrophil (PMN) migration into the airway and diminish PMN function in response to bacterial inoculation of the airway...
May 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28422989/the-lack-of-btk-does-not-impair-monocytes-and-polymorphonuclear-cells-functions-in-x-linked-agammaglobulinemia-under-treatment-with-intravenous-immunoglobulin-replacement
#6
Filomena Monica Cavaliere, Alessandro Prezzo, Caterina Bilotta, Metello Iacobini, Isabella Quinti
The lack of BTK in X-linked agammaglobulinemia (XLA) patients does not affect monocytes and polymorphonuclear cells (PMN) phenotype and functions. In this study, we show that XLA patients had an increased frequency of the intermediate monocytes subset and that BTK-deficient monocytes and PMN had a normal expression of receptors involved in the activation and cellular responses. We demonstrate that BTK is not required for migration, phagocytosis and the production of reactive oxygen species (ROS) following engagement of FC gamma receptors (FcγR)...
2017: PloS One
https://www.readbyqxmd.com/read/28420469/-heparin-reduces-endothelial-cell-damage-induced-by-neutrophil-extracellular-traps
#7
Yanting Qiao, Jing Jiang, Zhidan Zhang, Xiaochun Ma
OBJECTIVE: Clarify the effect of neutrophil extracellular traps (NETs) on endothelial cell injury, and investigate whether the heparin can exert a protective effect on endothelial cells by reducing the endothelial cell injury induced by NETs. METHODS: Neutrophils (PMN) were obtained from healthy human peripheral blood by Percoll-Histopaque density gradient centrifugation, and was stimulated with phorbol ester (PMA) to induce NETs. The qualitative and quantitative analysis of NETs was detected by immunofluorescence staining combined with fluorescence detector...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28417112/lectin-type-oxidized-ldl-receptor-1-distinguishes-population-of-human-polymorphonuclear-myeloid-derived-suppressor-cells-in-cancer-patients
#8
Thomas Condamine, George A Dominguez, Je-In Youn, Andrew V Kossenkov, Sridevi Mony, Kevin Alicea-Torres, Evgenii Tcyganov, Ayumi Hashimoto, Yulia Nefedova, Cindy Lin, Simona Partlova, Alfred Garfall, Dan T Vogl, Xiaowei Xu, Stella C Knight, George Malietzis, Gui Han Lee, Evgeniy Eruslanov, Steven M Albelda, Xianwei Wang, Jawahar L Mehta, Meenakshi Bewtra, Anil Rustgi, Neil Hockstein, Robert Witt, Gregory Masters, Brian Nam, Denis Smirnov, Manuel A Sepulveda, Dmitry I Gabrilovich
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) are important regulators of immune responses in cancer and have been directly implicated in promotion of tumor progression. However, the heterogeneity of these cells and lack of distinct markers hampers the progress in understanding of the biology and clinical importance of these cells. Using partial enrichment of PMN-MDSC with gradient centrifugation we determined that low density PMN-MDSC and high density neutrophils from the same cancer patients had a distinct gene profile...
August 2016: Science Immunology
https://www.readbyqxmd.com/read/28413026/the-balance-between-metalloproteinases-and-timps-critical-regulator-of-microvascular-endothelial-cell-function-in-health-and-disease
#9
Marcello G Masciantonio, Christopher K S Lee, Valerie Arpino, Sanjay Mehta, Sean E Gill
Endothelial cells (EC), especially the microvascular EC (MVEC), have critical functions in health and disease. For example, healthy MVEC provide a barrier between the fluid and protein found within the blood, and the surrounding tissue. Following tissue injury or infection, the microvascular barrier is often disrupted due to activation and dysfunction of the MVEC. Multiple mechanisms promote MVEC activation and dysfunction, including stimulation by cytokines, mechanical interaction with activated leukocytes, and exposure to harmful leukocyte-derived molecules, which collectively result in a loss of MVEC barrier function...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28410545/lps-stimulation-of-cord-blood-reveals-a-newborn-specific-neutrophil-transcriptomic-response-and-cytokine-production
#10
Brittany Mathias, Juan C Mira, Jonathan P Rehfuss, Jaimar C Rincon, Ricardo Ungaro, Dina C Nacionales, M Cecilia Lopez, Henry V Baker, Lyle L Moldawer, Shawn D Larson
BACKGROUND: The neonatal innate immune system differs to microbial infection both quantitatively and qualitatively when compared with adults. Here, we provide the first genome-wide ex-vivo expression profile of umbilical cord blood (UCB) neutrophils from full-term infants prior to and in response to whole-blood lipopolysaccharide (LPS) stimulation. Additionally, we provide cytokine expression prior to and following LPS stimulation. The genomic expression and cytokine profile are compared with LPS-stimulated whole blood from healthy adult subjects (HC)...
May 2017: Shock
https://www.readbyqxmd.com/read/28407857/a-review-of-the-ongoing-discussion-about-definition-diagnosis-and-pathomechanism-of-subclinical-endometritis-in-dairy-cows
#11
REVIEW
Karen Wagener, Christoph Gabler, Marc Drillich
In the last decade, several new aspects of the inflammation of the bovine endometrium have been investigated and described, including a new definition of subclinical endometritis. This review summarizes the recent discussion about the definition, diagnosis and pathomechanism of subclinical endometritis. Subclinical endometritis also referred to as cytological endometritis is defined by findings of endometrial cytology, which is usually performed with the cytobrush-technique or by low-volume flushing of the uterus...
May 2017: Theriogenology
https://www.readbyqxmd.com/read/28407427/microenvironmental-characteristics-and-physiology-of-biofilms-in-chronic-infections-of-cf-patients-are-strongly-affected-by-the-host-immune-response
#12
REVIEW
Peter Ø Jensen, Mette Kolpen, Kasper N Kragh, Michael Kühl
In vitro studies of Pseudomonas aeruginosa and other pathogenic bacteria in biofilm aggregates have yielded detailed insight into their potential growth modes and metabolic flexibility under exposure to gradients of substrate and electron acceptor. However, the growth pattern of P. aeruginosa in chronic lung infections of cystic fibrosis (CF) patients is very different from what is observed in vitro, for example, in biofilms grown in flow chambers. Dense in vitro biofilms of P. aeruginosa exhibit rapid O2 depletion within <50-100 μm due to their own aerobic metabolism...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28385925/neutrophil-myeloperoxidase-diminishes-the-toxic-effects-and-mortality-induced-by-lipopolysaccharide
#13
Laurent L Reber, Caitlin M Gillis, Philipp Starkl, Friederike Jönsson, Riccardo Sibilano, Thomas Marichal, Nicolas Gaudenzio, Marion Bérard, Stephan Rogalla, Christopher H Contag, Pierre Bruhns, Stephen J Galli
Neutrophils have crucial antimicrobial functions but are also thought to contribute to tissue injury upon exposure to bacterial products, such as lipopolysaccharide (LPS). To study the role of neutrophils in LPS-induced endotoxemia, we developed a new mouse model, PMN(DTR) mice, in which injection of diphtheria toxin induces selective neutrophil ablation. Using this model, we found, surprisingly, that neutrophils serve to protect the host from LPS-induced lethal inflammation. This protective role was observed in conventional and germ-free animal facilities, indicating that it does not depend on a particular microbiological environment...
April 6, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28382721/the-two-component-system-vicrk-regulates-functions-associated-with-streptococcus-mutans-resistance-to-complement-immunity
#14
Lívia A Alves, Erika N Harth-Chu, Thaís H Palma, Rafael N Stipp, Flávia S Mariano, José F Höfling, Jacqueline Abranches, Renata O Mattos-Graner
Streptococcus mutans, a dental caries pathogen, can promote systemic infections upon reaching the bloodstream. The two-component system (TCS) VicRKSm of S. mutans regulates the synthesis of and interaction with sucrose-derived exopolysaccharides (EPS), processes associated with oral and systemic virulence. In this study, we investigated the mechanisms by which VicRKSm affects S. mutans susceptibility to blood-mediated immunity. Compared to parent strain UA159, the vicKSm isogenic mutant (UAvic) showed reduced susceptibility to deposition of C3b of complement, low binding to serum IgG, and low frequency of C3b/IgG-mediated opsonophagocytosis by PMN in a sucrose-independent way (p<0...
April 5, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28382433/apoptosis-induced-by-low-level-laser-in-polymorphonuclear-cells-of-acute-joint-inflammation-comparative-analysis-of-two-energy-densities
#15
Lúcia Mara Januário Dos Anjos, Adenilson de Souza da Fonseca, Jacy Gameiro, Flávia de Paoli
Anti-inflammatory property of low-level laser therapy (LLLT) has been widely described in literature, although action mechanisms are not always clarified. Thus, this study aimed to evaluate apoptosis mechanisms in the LLLT anti-inflammatory effects on the arthritis experimental model in vivo at two different energy densities (3 and 30 Jcm(-2)). Arthritis was induced in mice by zymosan solution, animals were distributed into five groups, and morphological analysis, immunocytochemistry and gene expressions for apoptotic proteins were performed...
April 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28373994/neutrophil-extracellular-traps-and-microcrystals
#16
REVIEW
Balázs Rada
Neutrophil extracellular traps represent a fascinating mechanism by which PMNs entrap extracellular microbes. The primary purpose of this innate immune mechanism is thought to localize the infection at an early stage. Interestingly, the ability of different microcrystals to induce NET formation has been recently described. Microcrystals are insoluble crystals with a size of 1-100 micrometers that have different composition and shape. Microcrystals have it in common that they irritate phagocytes including PMNs and typically trigger an inflammatory response...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28369053/electric-field-control-of-deterministic-current-induced-magnetization-switching-in-a-hybrid-ferromagnetic-ferroelectric-structure
#17
Kaiming Cai, Meiyin Yang, Hailang Ju, Sumei Wang, Yang Ji, Baohe Li, Kevin William Edmonds, Yu Sheng, Bao Zhang, Nan Zhang, Shuai Liu, Houzhi Zheng, Kaiyou Wang
All-electrical and programmable manipulations of ferromagnetic bits are highly pursued for the aim of high integration and low energy consumption in modern information technology. Methods based on the spin-orbit torque switching in heavy metal/ferromagnet structures have been proposed with magnetic field, and are heading toward deterministic switching without external magnetic field. Here we demonstrate that an in-plane effective magnetic field can be induced by an electric field without breaking the symmetry of the structure of the thin film, and realize the deterministic magnetization switching in a hybrid ferromagnetic/ferroelectric structure with Pt/Co/Ni/Co/Pt layers on PMN-PT substrate...
April 3, 2017: Nature Materials
https://www.readbyqxmd.com/read/28365116/differential-somatic-cell-count-a-novel-method-for-routine-mastitis-screening-in-the-frame-of-dairy-herd-improvement-testing-programs
#18
Malin Damm, Claus Holm, Mette Blaabjerg, Morten Novak Bro, Daniel Schwarz
Somatic cell count (SCC) is used as key indicator in mastitis screening programs typically applied in the frame of Dairy Herd Improvement (DHI) testing programs. However, mastitis is still causing tremendous economic losses to the dairy industry. Hence, new biomarkers are needed that can be used for enhanced management of mastitis on dairy farms. Besides the determination of SCC, differentiation of cells has been described to be beneficial for a more definite description of the actual udder health status of dairy cows...
March 29, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28363573/effects-of-fucoidans-and-heparin-on-reactions-of-neutrophils-induced-by-il-8-and-c5a
#19
Inga Liewert, Karina Ehrig, Susanne Alban
Fucose-containing sulfated polysaccharides (fucoidans) from brown algae exhibit anti-inflammatory activity in vivo, however, there is only limited knowledge about their mode of action. Potential targets may be the chemokine interleukin 8 (IL-8) and the anaphylatoxin C5a, as they are closely linked to inflammatory processes. In this study, two fucoidans from Saccharina latissima and Fucus vesiculosus, and unfractionated heparin (UFH) were examined for their binding properties to IL-8 and C5a and their effects on IL-8- and C5a-induced reactions of polymorphonuclear neutrophils (PMN)...
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28356386/the-granulocyte-progenitor-stage-is-a-key-target-of-irf8-mediated-regulation-of-myeloid-derived-suppressor-cell-production
#20
Colleen S Netherby, Michelle N Messmer, Lauren Burkard-Mandel, Sean Colligan, Austin Miller, Eduardo Cortes Gomez, Jianmin Wang, Michael J Nemeth, Scott I Abrams
Alterations in myelopoiesis are common across various tumor types, resulting in immature populations termed myeloid-derived suppressor cells (MDSCs). MDSC burden correlates with poorer clinical outcomes, credited to their ability to suppress antitumor immunity. MDSCs consist of two major subsets, monocytic and polymorphonuclear (PMN). Intriguingly, the latter subset predominates in many patients and tumor models, although the mechanisms favoring PMN-MDSC responses remain poorly understood. Ordinarily, lineage-restricted transcription factors regulate myelopoiesis that collectively dictate cell fate...
March 29, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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