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https://www.readbyqxmd.com/read/29035348/air-coupled-ultrasonic-receivers-with-high-electromechanical-coupling-pmn-32-pt-strip-like-piezoelectric-elements
#1
Rymantas J Kazys, Reimondas Sliteris, Justina Sestoke
For improvement of the efficiency of air-coupled ultrasonic transducers PMN-32%PT piezoelectric crystals which possess very high piezoelectric properties may be used. The electromechanical coupling factor of such crystals for all main vibration modes such as the thickness extension and transverse extension modes is more than 0.9. Operation of ultrasonic transducers with such piezoelectric elements in transmitting and receiving modes is rather different. Therefore, for transmission and reception of ultrasonic signals, separate piezoelectric elements with different dimensions must be used...
October 16, 2017: Sensors
https://www.readbyqxmd.com/read/29030133/use-of-a-national-database-as-a-tool-to-identify-primary-medication-non-adherence-the-estonian-eprescription-system
#2
Ott Laius, Heti Pisarev, Daisy Volmer, Sulev Kõks, Aare Märtson, Katre Maasalu
BACKGROUND: Medication adherence can be divided into primary and secondary adherence. Primary medication non-adherence (PMN) occurs when a patient does not obtain medicine with their initial prescription. Secondary non-adherence measures prescription refills among patients who previously filled their first prescription. While secondary non-adherence has been studied thoroughly, PMN has been assessed less extensively, due to lack of available data. Estonian ePrescription system might prove a valuable tool for this...
October 5, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29021368/spontaneous-pmn-apoptosis-in-type-2-diabetes-and-the-impact-of-periodontitis
#3
Aggasit Manosudprasit, Alpdogan Kantarci, Hatice Hasturk, Danielle Stephens, Thomas E Van Dyke
The purpose of this study was to test the hypothesis that peripheral blood neutrophils (PMN) exhibit delayed spontaneous apoptosis in individuals with diabetes mellitus type 2 (T2DM) and that the delay is exacerbated further among people who coexpress chronic periodontitis (CP). Seventy-three individuals were enrolled, including those with T2DM (n = 16), CP (n = 15), T2DM + CP (n = 21), and healthy volunteers (n = 21). PMN apoptosis was determined by flow cytometry using TUNEL and Annexin V assays. The activity of caspase-3, -8, and -9 was measured by colorimetric assay...
October 11, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28962192/clinical-significance-of-mechanical-ventilation-on-ischemic-reperfusion-injury-caused-by-lung-chest-trauma-and-vegf-expression-levels-in-peripheral-blood
#4
Zhong-Yi Sun, Hong-Gang Xia, De-Qing Zhu, Li-Min Deng, Peng-Zhi Zhu, Dong-Bin Wang
We investigated the clinical significance of mechanical ventilation on ischemic-reperfusion injury caused by lung chest trauma as well as vascular endothelial growth factor (VEGF) expression levels in peripheral blood. Sixty-eight patients with severe chest trauma complicated with acute respiratory distress syndrome that were treated at our Tianjin Hospital from September 2013 to July 2016 were recruited. These patients were randomly and evenly divided into two groups, the research group and the control group...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28961278/nlrc4-regulates-caspase-1-and-il-1beta-production-in-a-cd11blowly6glow-population-of-cells-required-for-resistance-to-pseudomonas-aeruginosa-keratitis
#5
Sharon A McClellan, Andrew Jerome, Susmit Suvas, Linda D Hazlett
Psbetaeudomonas (P.) aeruginosa infection of the cornea in BALB/c mice does not result in perforation and the mice have been classified as resistant. However, regulation of this response via inflammasome activation remained untested. Therefore, BALB/c mice were infected with P. aeruginosa ATCC strain 19660 and NLRP3 and NLRC4 protein tested by ELISA. Since NLRC4 vs NLRP3 protein levels were significantly higher in the corneas of BALB/c at 1 and 5 days postinfection we used silencing to knockdown NLRC4. Silencing NLRC4 vs scrambled siRNA treatment exacerbated disease in BALB/c mice, reduced myeloperoxidase levels and elevated bacterial plate counts at 5 days postinfection...
2017: PloS One
https://www.readbyqxmd.com/read/28951834/bottlenose-dolphins-tursiops-truncatus-do-also-cast-neutrophil-extracellular-traps-against-the-apicomplexan-parasite-neospora-caninum
#6
R Villagra-Blanco, L M R Silva, A Aguilella-Segura, I Arcenillas-Hernández, C Martínez-Carrasco, A Seipp, U Gärtner, R Ruiz de Ybañez, A Taubert, C Hermosilla
Neutrophil extracellular traps (NETs) are web-like structures composed of nuclear DNA decorated with histones and cytoplasmic peptides which antiparasitic properties have not previously been investigated in cetaceans. Polymorphonuclear neutrophils (PMN) were isolated from healthy bottlenose dolphins (Tursiops truncatus), and stimulated with Neospora caninum tachyzoites and the NETs-agonist zymosan. In vitro interactions of PMN with the tachyzoites resulted in rapid extrusion of NETs. For the demonstration and quantification of cetacean NETs, extracellular DNA was stained by using either Sytox Orange(®) or Pico Green(®)...
December 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28951418/lamina-propria-group-2-innate-lymphoid-cells-impair-the-antibacterial-defense-of-burned-mice-to-enterococcal-translocation
#7
Ichiaki Ito, Kamlesh K Bhopale, Makiko Kobayashi, Celeste C Finnerty, David N Herndon, Fujio Suzuki
Gut microbiota that invades to the defective mucosal barrier is one of the major sources of infectious complications in severely burned hosts. In this study, a role of group 2 innate lymphoid cells (ILC2) and effects of N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-2-thiophenesulfonamide (SR3335) on the host antibacterial resistance against infectious complications caused by Enterococcus faecalis oral infection were investigated in burned mice. Retinoic acid receptor-related orphan receptor α (RORα) is a transcription factor required for the development of ILC2, and SR3335 is an RORα-selective inverse agonist...
September 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28948771/electric-field-manipulated-multilevel-magnetic-states-storage-in-fept-011-pmn-pt-heterostructure
#8
Xiaoyu Zhao, Jiahong Wen, Bo Yang, Huachen Zhu, Qingqi Cao, Dunhui Wang, Zhenghong Qian, Youwei Du
In the current information society, the realization of a magnetic storage technique with energy-efficient design and high storage density is greatly desirable. Here, we demonstrate that, without bias magnetic field, different values of remanent magnetization (Mr) can be obtained in a FePt/0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (PMN-PT) heterostructure by applying a unipolar electric field across the substrate. These multilevel magnetic signals can serve as writing data bits in a storage device, which remarkably increases the storage density...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28940295/comparing-leukapheresis-protocols-for-an-aml-patient-with-symptomatic-leukostasis
#9
Abigail Cline, Ryan Jajosky, James Shikle, Roni Bollag
BACKGROUND: Acute myeloid leukemia (AML) is a malignancy characterized by rapid clonal proliferation of myeloid precursors, which can result in hyperleukocytosis. Leukapheresis can be used to rapidly reduce the white blood cell count (WBC). However, the only FDA cleared device for WBC depletion, the COBE Spectra, will no longer be supported by the manufacturer in 2017, and there are few studies comparing different methods of leukapheresis. CASE REPORT: A 68-year-old African American female was admitted to the hospital for relapse of her AML...
September 22, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28939663/hepatoma-intrinsic-ccrk-inhibition-diminishes-myeloid-derived-suppressor-cell-immunosuppression-and-enhances-immune-checkpoint-blockade-efficacy
#10
Jingying Zhou, Man Liu, Hanyong Sun, Yu Feng, Liangliang Xu, Anthony W H Chan, Joanna H Tong, John Wong, Charing Ching Ning Chong, Paul B S Lai, Hector Kwong-Sang Wang, Shun-Wa Tsang, Tyler Goodwin, Rihe Liu, Leaf Huang, Zhiwei Chen, Joseph Jy Sung, King Lau Chow, Ka Fai To, Alfred Sze-Lok Cheng
OBJECTIVE: Myeloid-derived suppressor cells (MDSCs) contribute to tumour immunosuppressive microenvironment and immune-checkpoint blockade resistance. Emerging evidence highlights the pivotal functions of cyclin-dependent kinases (CDKs) in tumour immunity. Here we elucidated the role of tumour-intrinsic CDK20, or cell cycle-related kinase (CCRK) on immunosuppression in hepatocellular carcinoma (HCC). DESIGN: Immunosuppression of MDSCs derived from patients with HCC and relationship with CCRK were determined by flow cytometry, expression analyses and co-culture systems...
September 22, 2017: Gut
https://www.readbyqxmd.com/read/28935207/effects-of-energy-supply-and-nicotinic-acid-supplementation-on-phagocytosis-and-ros-production-of-blood-immune-cells-of-periparturient-primi-and-pluriparous-dairy-cows
#11
S Bühler, J Frahm, W Liermann, R Tienken, S Kersten, U Meyer, K Huber, S Dänicke
Effects of energy supply and nicotinic acid (NA) supplementation on the phagocytic activity of polymorphonuclear leukocytes (PMN) and peripheral blood mononuclear cells (PBMC), and on ROS production in PMN of periparturient cows differing in parity were examined. 29 pluriparous and 18 primiparous cows were allocated to four different feeding groups from 42days prepartum until 100days postpartum. They were fed either a ration with a low concentrate proportion of 30% (LC) or a high concentrate proportion of 60% (HC)...
September 11, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28931657/neutrophil-transfer-of-mir-223-to-lung-epithelial-cells-dampens-acute-lung-injury-in-mice
#12
Viola Neudecker, Kelley S Brodsky, Eric T Clambey, Eric P Schmidt, Thomas A Packard, Bennett Davenport, Theodore J Standiford, Tingting Weng, Ashley A Fletcher, Lea Barthel, Joanne C Masterson, Glenn T Furuta, Chunyan Cai, Michael R Blackburn, Adit A Ginde, Michael W Graner, William J Janssen, Rachel L Zemans, Christopher M Evans, Ellen L Burnham, Dirk Homann, Marc Moss, Simone Kreth, Kai Zacharowski, Peter M Henson, Holger K Eltzschig
Intercellular transfer of microRNAs can mediate communication between critical effector cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial cells could alter mucosal gene expression during acute lung injury. Pulmonary-epithelial microRNA profiling during coculture of alveolar epithelial cells with polymorphonuclear neutrophils (PMNs) revealed a selective increase in lung epithelial cell expression of microRNA-223 (miR-223). Analysis of PMN-derived supernatants showed activation-dependent release of miR-223 and subsequent transfer to alveolar epithelial cells during coculture in vitro or after ventilator-induced acute lung injury in mice...
September 20, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28927450/unit-cost-of-healthcare-services-at-200-bed-public-hospitals-in-myanmar-what-plays-an-important-role-of-hospital-budgeting
#13
Thet Mon Than, Yu Mon Saw, Moe Khaing, Ei Mon Win, Su Myat Cho, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima
BACKGROUND: Cost information is important for efficient allocation of healthcare expenditure, estimating future budget allocation, and setting user fees to start new financing systems. Myanmar is in political transition, and trying to achieve universal health coverage by 2030. This study assessed the unit cost of healthcare services at two public hospitals in the country from the provider perspective. The study also analyzed the cost structure of the hospitals to allocate and manage the budgets appropriately...
September 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28890882/neutrophils-to-the-roscue-mechanisms-of-nadph-oxidase-activation-and-bacterial-resistance
#14
REVIEW
Giang T Nguyen, Erin R Green, Joan Mecsas
Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent and severe bacterial infections, while their unregulated release leads to pathology from excessive inflammation. The release of high concentrations of ROS aids in clearance of invading bacteria. Localization of ROS release to phagosomes containing pathogens limits tissue damage. Host immune cells, like neutrophils, also known as PMNs, will release large amounts of ROS at the site of infection following the activation of surface receptors...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28888778/mincle-inhibits-neutrophils-and-macrophages-apoptosis-in-a-fumigatus-keratitis
#15
Jing Lin, Kun He, Guiqiu Zhao, Cui Li, Liting Hu, Guoqiang Zhu, Yawen Niu, Guipei Hao
PURPOSE: To determine whether macrophage inducible C-type lectin (Mincle) regulates neutrophils and macrophages apoptosis in A. fumigatus keratitis. MATERIALS AND METHODS: A murine model (C57BL/6) of fungal keratitis (AF) was established by gently scraping corneal central epithelium, smearing A. fumigatus on the epithelium surface and covering the eye with contact lenses. AF cell model was established by extracting neutrophils (PMN) and macrophages, and then infecting cells with A...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28884136/neutrophils-as-components-of-mucosal-homeostasis
#16
REVIEW
Caroline H T Hall, Eric L Campbell, Sean P Colgan
Inflammatory responses in the intestinal mucosa inevitably result in the recruitment of neutrophils (polymorphonuclear leukocytes [PMNs]). Epithelial cells that line the mucosa play an integral role in the recruitment, maintenance, and clearance of PMNs at sites of inflammation. The consequences of such PMN-epithelial interactions often determine tissue responses and, ultimately, organ function. For this reason, there is significant interest in understanding how PMNs function in the mucosa during inflammation...
November 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28880373/supernatants-and-lipids-from-stored-red-blood-cells-activate-pulmonary-microvascular-endothelium-through-the-blt2-receptor-and-protein-kinase-c-activation
#17
Christopher C Silliman, Marguerite R Kelher, Samina Y Khan, F Bernadette West, Nathan J D McLaughlin, David J Elzi, Kelly England, Jason Bjornsen, Susan A Kuldanek, Anirban Banerjee
BACKGROUND: Although transfusion is a lifesaving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored red blood cells (RBCs) induce proinflammatory activation of human pulmonary microvascular endothelial cells (HMVECs) resulting in neutrophil (PMN) adhesion and predisposition to acute lung injury (ALI). STUDY DESIGN AND METHODS: Ten units of RBCs were collected; 50% (by weight) were leukoreduced (LR-RBCs) and the remainder was unmodified and stored in additive solution-5 (AS-5)...
September 6, 2017: Transfusion
https://www.readbyqxmd.com/read/28879509/il26-modulates-cytokine-response-and-anti-tnf-consumption-in-crohn-s-disease-patients-with-bacterial-dna
#18
Paula Piñero, Oriol Juanola, Ana Gutiérrez, Pedro Zapater, Paula Giménez, Anna Steinert, Laura Sempere, José M González-Navajas, Jan H Niess, Rubén Francés
Interleukin IL26 supports killing of microbes and the innate sensing of bacterial-derived DNA (bactDNA). We evaluated the relationship between IL26 serum levels and bactDNA translocation in Crohn's disease (CD). We ran a prospective study on CD patients in remission. IL26 common polymorphisms, serum cytokines and complement protein, amplified-bactDNA, and anti-TNF-α were evaluated. In vitro PBMC analysis was performed. Three hundred and thirteen patients were included (mean CDAI: 83.6 ± 32.8; mean fecal calprotectin: 55...
September 6, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28873396/a-mouse-mastitis-model-to-study-the-effects-of-the-intramammary-infusion-of-a-food-grade-lactococcus-lactis-strain
#19
Cristina Camperio, Federica Armas, Elena Biasibetti, Paolo Frassanito, Carlo Giovannelli, Liliana Spuria, Claudia D'Agostino, Sabrina Tait, Maria Teresa Capucchio, Cinzia Marianelli
Lactococcus lactis is one of the most important microorganisms in the dairy industry and has "generally recognized as safe" (GRAS) status. L. lactis belongs to the group of lactic acid bacteria (LAB) and is encountered in a wide range of environments. Recently, the use of the intramammary infusion of a live culture of LAB has been investigated as a new antibiotic alternative for treating mastitis in dairy ruminants. Controversial results are described in literature regarding its efficacy and safety. In this study we conducted in-depth investigation of the mammary gland immune response induced by intramammary inoculum of a live culture of L...
2017: PloS One
https://www.readbyqxmd.com/read/28866874/two-site-evaluation-of-the-diagnostic-performance-of-the-sysmex-xn-body-fluid-bf-module-for-cell-count-and-differential-in-cerebrospinal-fluid
#20
S Buoro, B Peruzzi, A Fanelli, M Seghezzi, B Manenti, M Lorubbio, T Biagioli, S Nannini, C Ottomano, G Lippi
INTRODUCTION: Cellular analysis in cerebrospinal fluid (CSF) provides important diagnostic information in many pathological settings. The aim of this two-site study was to evaluate the Sysmex XN Body Fluid mode (XN-BF) for cell analysis of CSF compared to light microscopy (LM). METHODS: Two hundred and seven consecutive CSF samples were analyzed in parallel with XN-BF and LM. The study also included the estimation of the limit of blank (LoB), limit of detection (LoD), limit of quantitation (LoQ), carry-over and linearity of XN-BF module...
September 3, 2017: International Journal of Laboratory Hematology
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