keyword
https://read.qxmd.com/read/38532759/closure-of-tb-pulmonary-cavern-using-endobronchial-valve-placement
#1
Teona Mskhaladze, David Tchkonia, Kakha Vacharadze, Nana Kiria, Mikolay Chkonia
INTRODUCTION: Enhancing the efficacy of treatment for Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) Tuberculosis has prompted exploration into adjunctive therapies, such as Endobronchial Valve Placement (EVP) in addition to pharmacological interventions. MATERIALS AND METHODS: EVP was performed utilizing a combination of rigid and flexible bronchoscopes to address airway hemorrhage and facilitate closure of TB cavities. The procedure involved the deployment of large valves (12 mm and 17 mm), necessitating the utilization of a rigid bronchoscope...
March 2024: Oxford Medical Case Reports
https://read.qxmd.com/read/38531172/identifying-local-foci-of-tuberculosis-transmission-in-moldova-using-a-spatial-multinomial-logistic-regression-model
#2
JOURNAL ARTICLE
Yu Lan, Valeriu Crudu, Nelly Ciobanu, Alexandru Codreanu, Melanie H Chitwood, Benjamin Sobkowiak, Joshua L Warren, Ted Cohen
BACKGROUND: Multidrug resistant tuberculosis (MDR-TB) represents a major public health concern in the Republic of Moldova, with an estimated 31% of new and 56% of previously treated TB cases having MDR disease in 2022. A recent genomic epidemiology study of incident TB occurring in 2018 and 2019 found that 92% of MDR-TB was the result of transmission. The MDR phenotype was concentrated among two M. tuberculosis (Mtb) lineages: L2.2.1 (Beijing) and L4.2.1 (Ural). METHODS: We developed and applied a hierarchical Bayesian multinominal logistic regression model to Mtb genomic, spatial, and epidemiological data collected from all individuals with diagnosed TB in Moldova in 2018 and 2019 to identify locations in which specific Mtb strains are being transmitted...
March 25, 2024: EBioMedicine
https://read.qxmd.com/read/38523706/rifampicin-resistant-mycobacterium-tuberculosis-in-vietnam-2020-2022
#3
JOURNAL ARTICLE
Hung Van Nguyen, Hoa Binh Nguyen, Doan Thu Ha, Dinh Thi Huong, Vu Ngoc Trung, Khieu Thi Thuy Ngoc, Tran Huyen Trang, Ha Vu Thi Ngoc, Tram Trinh Thi Bich, Trieu Le Pham Tien, Hanh Nguyen Hong, Phu Phan Trieu, Luong Kim Lan, Kim Lan, Ngo Ngoc Hue, Nguyen Thi Le Huong, Tran Le Thi Ngoc Thao, Nguyen Le Quang, Thu Do Dang Anh, Nguyễn Hữu Lân, Truong Van Vinh, Dang Thi Minh Ha, Phan Thuong Dat, Nguyen Phuc Hai, Derrick W Crook, Nguyen Thuy Thuong Thuong, Nhung Viet Nguyen, Guy E Thwaites, Timothy M Walker
OBJECTIVE: We conducted a descriptive analysis of multi-drug resistant tuberculosis (MDR-TB) in Vietnam's two largest cities, Hanoi and Ho Chi Minh city. METHODS: All patients with rifampicin resistant tuberculosis were recruited from Hanoi and surrounding provinces between 2020 and 2022. Additional patients were recruited from Ho Chi Minh city over the same time period. Demographic data were recorded from all patients, and samples collected, cultured, whole genome sequenced and analysed for drug resistance mutations...
May 2024: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://read.qxmd.com/read/38523140/multidrug-resistant-tuberculosis
#4
REVIEW
Keertan Dheda, Fuad Mirzayev, Daniela Maria Cirillo, Zarir Udwadia, Kelly E Dooley, Kwok-Chiu Chang, Shaheed Vally Omar, Anja Reuter, Tahlia Perumal, C Robert Horsburgh, Megan Murray, Christoph Lange
Tuberculosis (TB) remains the foremost cause of death by an infectious disease globally. Multidrug-resistant or rifampicin-resistant TB (MDR/RR-TB; resistance to rifampicin and isoniazid, or rifampicin alone) is a burgeoning public health challenge in several parts of the world, and especially Eastern Europe, Russia, Asia and sub-Saharan Africa. Pre-extensively drug-resistant TB (pre-XDR-TB) refers to MDR/RR-TB that is also resistant to a fluoroquinolone, and extensively drug-resistant TB (XDR-TB) isolates are additionally resistant to other key drugs such as bedaquiline and/or linezolid...
March 24, 2024: Nature Reviews. Disease Primers
https://read.qxmd.com/read/38521375/development-of-a-self-microemulsifying-drug-delivery-system-to-deliver-delamanid-via-a-pressurized-metered-dose-inhaler-for-treatment-of-multi-drug-resistant-pulmonary-tuberculosis
#5
JOURNAL ARTICLE
Himanshu Paliwal, Titpawan Nakpheng, Pijush Kumar Paul, K Prem Ananth, Teerapol Srichana
Tuberculosis (TB) is a serious health issue that contributes to millions of deaths throughout the world and increases the threat of serious pulmonary infections in patients with respiratory illness. Delamanid is a novel drug approved in 2014 to deal with multi-drug resistant TB (MDR-TB). Despite its high efficiency in TB treatment, delamanid poses delivery challenges due to poor water solubility leading to inadequate absorption upon oral administration. This study involves the development of novel formulation-based pressurized metered dose inhalers (pMDIs) containing self-microemulsifying mixtures of delamanid for efficient delivery to the lungs...
March 21, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38518003/multidrug-resistant-mycobacterium-tuberculosis-transmission-in-shandong-china
#6
JOURNAL ARTICLE
Yingying Li, Yifan Li, Tingting Wang, Yameng Li, Ningning Tao, Xianglong Kong, Yuzhen Zhang, Qilin Han, Yao Liu, Huaichen Li
Multidrug-resistant tuberculosis (MDR-TB) has imposed a significant economic and health burden worldwide, notably in China. Using whole genome sequence, we sought to understand the mutation and transmission of MDR-TB in Shandong. A retrospective study of patients diagnosed with pulmonary tuberculosis in Shandong from 2009 to 2018 was conducted. To explore transmission patterns, we performed whole genome sequencing on MDR-TB isolates, identified genomic clusters, and assessed the drug resistance of TB isolates...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38516788/characteristic-snps-defining-the-major-multidrug-resistant-mycobacterium-tuberculosis-clusters-identified-by-euseqmytb-to-support-routine-surveillance-eu-eea-2017-to-2019
#7
JOURNAL ARTICLE
Albert J de Neeling, Elisa Tagliani, Csaba Ködmön, Marieke J van der Werf, Dick van Soolingen, Daniela Maria Cirillo, Richard M Anthony
BackgroundThe EUSeqMyTB project, conducted in 2020, used whole genome sequencing (WGS) for surveillance of drug-resistant Mycobacterium tuberculosis in the European Union/European Economic Area (EU/EEA) and identified 56 internationally clustered multidrug-resistant (MDR) tuberculosis (TB) clones.AimWe aimed to define and establish a rapid and computationally simple screening method to identify probable members of the main cross-border MDR-TB clusters in WGS data to facilitate their identification and track their future spread...
March 2024: Euro Surveillance
https://read.qxmd.com/read/38515492/anxiety-and-depression-level-of-patients-with-multidrug-resistant-tuberculosis-mdr-tb-in-two-hospitals-in-banten-province-indonesia
#8
JOURNAL ARTICLE
Tirta Darmawan Susanto, Allen Widysanto, Darien Alfa Cipta, Arron Tanara, Ghivarell Rizkie Wirawan, Adeline Bercadina Kosim, Christabella Maria Djoni, Ervinna Tantri, Chandni Kumar, Chelsie Angelius
PURPOSE: Anxiety and depression can be found in patients diagnosed with multidrug-resistant Tuberculosis (MDR-TB). The purpose of this research is to measure the level of anxiety and depression in new patients with MDR-TB. METHODS: One hundred two new patients newly diagnosed with MDR TB in two hospitals in Banten province, Indonesia, are measured for depression and anxiety symptoms. The measurements used the Indonesian language version of the Zung Anxiety Self-Assessment Scale Questionnaire and the Indonesian version of Zung Self-Rating Depression Scale Questionnaire for Pulmonary Tuberculosis Patients that have been validated...
December 2023: Dialogues Health
https://read.qxmd.com/read/38510351/spatial-pattern-of-isoniazid-resistant-tuberculosis-and-its-associated-factors-among-a-population-with-migrants-in-china-a-retrospective-population-based-study
#9
JOURNAL ARTICLE
Hongyin Zhang, Ruoyao Sun, Zheyuan Wu, Yueting Liu, Meiru Chen, Jinrong Huang, Yixiao Lv, Fei Zhao, Yangyi Zhang, Minjuan Li, Hongbing Jiang, Yiqiang Zhan, Jimin Xu, Yanzi Xu, Jianhui Yuan, Yang Zhao, Xin Shen, Chongguang Yang
BACKGROUND: Isoniazid-resistant, rifampicin-susceptible tuberculosis (Hr-TB) globally exhibits a high prevalence and serves as a potential precursor to multidrug-resistant tuberculosis (MDR-TB). Recognizing the spatial distribution of Hr-TB and identifying associated factors can provide strategic entry points for interventions aimed at early detection of Hr-TB and prevention of its progression to MDR-TB. This study aims to analyze spatial patterns and identify socioeconomic, demographic, and healthcare factors associated with Hr-TB in Shanghai at the county level...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38509309/associations-of-residential-greenness-exposure-and-ambient-air-pollutants-with-newly-diagnosed-drug-resistant-tuberculosis-cases
#10
JOURNAL ARTICLE
Wan-Mei Song, Yi Liu, Dan Men, Shi-Jin Li, Ning-Ning Tao, Qian-Yun Zhang, Si-Qi Liu, Qi-Qi An, Xue-Han Zhu, Qi-Lin Han, Yu-Zhen Zhang, Ying-Ying Li, Chun-Xiao Li, Yao Liu, Chun-Bao Yu, Yi-Fan Li, Huai-Chen Li
Growing evidence has found the health protective effects of greenness exposure on tuberculosis (TB) and the impact of ambient air pollutants on TB drug-resistance. However, it remains unclear whether residential greenness is also beneficial to reduce TB drug-resistance, and whether air pollution modify the greenness-TB resistance relationship. We enrolled 5006 newly-diagnosed TB patients from Shandong, China, during 2014 to 2021. Normalized Difference Vegetation Index (NDVI) in 250 m and 500 m buffer around individuals' residential zone was used to assess greenness exposure...
March 20, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38500964/prison-as-a-driver-of-recent-transmissions-of-multidrug-resistant-tuberculosis-in-callao-peru-a-cross-sectional-study
#11
JOURNAL ARTICLE
Christian Utpatel, Milagros Zavaleta, Daniel Rojas-Bolivar, Andreas Mühlbach, Janet Picoy, Walter Portugal, Ana Esteve-Solé, Laia Alsina, Paolo Miotto, Daniella C Bartholomeu, Jorge Sanchez, Diego F Cuadros, Jorge O Alarcon, Stefan Niemann, Moises A Huaman
BACKGROUND: We sought to identify resistance patterns and key drivers of recent multidrug-resistant tuberculosis (MDR-TB) transmission in a TB-prevalent area in Peru. METHODS: Cross-sectional study including MDR Mycobacterium tuberculosis complex (Mtbc) strains identified in Callao-Peru between April 2017 and February 2019. Mtbc DNA was extracted for whole genome sequencing which was used for phylogenetic inference, clustering, and resistance mutation analyses. Clusters indicative of recent transmission were defined based on a strain-to-strain distance of ≤5 (D5) single nucleotide polymorphisms (SNPs)...
March 2024: Lancet Reg Health Am
https://read.qxmd.com/read/38488133/multidrug-resistant-tuberculosis-latest-opinions-on-epidemiology-rapid-diagnosis-and-management
#12
JOURNAL ARTICLE
Peter S Nyasulu, Cheick Oumar Doumbia, Veranyuy Ngah, Antieme Combo Georges Togo, Bassirou Diarra, Gershom Chongwe
PURPOSE OF REVIEW: This review addresses the escalating global challenge of multidrug-resistant tuberculosis (MDR-TB) in Sub-Saharan Africa, with a focus on its complex comorbidity with HIV/AIDS. Emphasizing the urgency of the issue, the review aims to shed light on the unique healthcare landscape shaped by the convergence of high prevalence rates and intersecting complexities with HIV/AIDS in the region. RECENT FINDINGS: A notable increase in MDR-TB cases across Sub-Saharan Africa is attributed to challenges in timely diagnoses, treatment initiation, and patient treatment defaulting...
March 18, 2024: Current Opinion in Pulmonary Medicine
https://read.qxmd.com/read/38481653/trends-of-drug-resistant-tuberculosis-in-an-urban-and-a-rural-area-in-china-a-10-year-population-based-molecular-epidemiological-study
#13
JOURNAL ARTICLE
Peng Xu, Meng Li, Qi Jiang, Chongguang Yang, Xiangxiang Liu, Howard Takiff, Qian Gao
OBJECTIVE: Drug resistance is the critical determinant for appropriate tuberculosis (TB) treatment regimens and an important indicator of the local TB burden. We aimed to investigate and compare trends in TB drug resistance in the urban Songjiang District of Shanghai from 2011 to 2020, and the rural Wusheng County of Sichuan Province from 2009 to 2020, to assess the effectiveness of local TB control and treatment programs. METHODS: Whole-genome sequencing data of Mycobacterium tuberculosis were used to predict drug-resistance profiles and identify genomic clusters...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38470194/sub-mic-levels-of-bedaquiline-and-clofazimine-can-select-mycobacterium-tuberculosis-mutants-with-increased-mic
#14
JOURNAL ARTICLE
Cristina Villellas, Frederik Stevenaert, Bart Remmerie, Koen Andries
Multidrug-resistant tuberculosis (MDR-TB) patients not cured at the time of stopping treatment are exposed to Minimum Inhibitory Concentration (MIC) and sub-MIC levels for many months after discontinuing bedaquiline (BDQ) or clofazimine (CFZ) treatment. In vitro cultures treated with BDQ and CFZ sub-MIC concentrations clearly showed enrichment in the Rv0678 mutant population, demonstrating that pre-existing Rv0678 mutants can be selected by sub-MIC concentrations of BDQ and CFZ if not protected by an alternative MDR-TB treatment...
March 12, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38469378/south-african-adolescents-lived-experiences-of-acquired-hearing-loss-following-multidrug-resistant-tuberculosis-treatment
#15
JOURNAL ARTICLE
Tarryn Sparg, Lucretia Petersen, Pat Mayers, Christine Rogers
OBJECTIVE: The impact of acquiring hearing loss might be exacerbated during adolescence, as this normal transition from childhood to adulthood is characterised by identity construction and social intensity. This study aimed to describe the lived experiences of South African adolescents with acquired hearing loss following aminoglycoside treatment for multidrug resistant tuberculosis. DESIGN: The study adopted a descriptive phenomenological design and in-depth, semi-structured interviews were conducted in English, isiZulu and Afrikaans...
2024: Front Rehabil Sci
https://read.qxmd.com/read/38459759/pharmacokinetics-and-pharmacodynamics-of-high-dose-isoniazid-for-the-treatment-of-rifampicin-or-multidrug-resistant-tuberculosis-in-indonesia
#16
JOURNAL ARTICLE
Vycke Yunivita, Fajri Gafar, Prayudi Santoso, Lidya Chaidir, Arto Y Soeroto, Triana N Meirina, Lindsey Te Brake, Dick Menzies, Rob E Aarnoutse, Rovina Ruslami
BACKGROUND: Pharmacokinetic data on high-dose isoniazid for the treatment of rifampicin-/multidrug-resistant tuberculosis (RR/MDR-TB) are limited. We aimed to describe the pharmacokinetics of high-dose isoniazid, estimate exposure target attainment, identify predictors of exposures, and explore exposure-response relationships in RR/MDR-TB patients. METHODS: We performed an observational pharmacokinetic study, with exploratory pharmacokinetic/pharmacodynamic analyses, in Indonesian adults aged 18-65 years treated for pulmonary RR/MDR-TB with standardized regimens containing high-dose isoniazid (10-15 mg/kg/day) for 9-11 months...
March 9, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38455633/efficacy-of-pretomanid-containing-regiments-for-drug-resistant-tuberculosis-a-systematic-review-and-meta-analysis-of-clinical-trials
#17
JOURNAL ARTICLE
Arya M Simanjuntak, Raehan Daenansya, Putri M Aflandhanti, Indra Yovi, Suyanto Suyanto, Dewi Anggraini, Dani Rosdiana
Concerns regarding the rise of drug-resistant tuberculosis (DR-TB) infections and the need for new drugs with shorter treatment time and fewer side effects have been voiced by the World Health Organization (WHO). The WHO revised its guideline to treat multidrug resistant tuberculosis (MDR-TB) with a 6-month course of BPaLM (bedaquiline, pretomanid, linezolid and moxifloxacin) in 2022. However, a thorough study and meta-analysis of available evidence is required due to the limited confidence of the evidence confirming the effectiveness of pretomanid-containing regiments...
December 2023: Narra J
https://read.qxmd.com/read/38453064/particulate-matter-deposition-and-its-impact-on-tuberculosis-severity-a-cross-sectional-study-in-taipei
#18
JOURNAL ARTICLE
Firdian Makrufardi, Hsiao-Chi Chuang, Chi-Won Suk, Yuan-Chien Lin, Desy Rusmawatiningtyas, Indah Kartika Murni, Eggi Arguni, Kian Fan Chung, Kuan-Jen Bai
The objective of this study was to examine the association between the lung lobe-deposited dose of inhaled fine particulate matter (PM2.5 ) and chest X-ray abnormalities in different lung lobes of pulmonary tuberculosis (TB), multidrug-resistant tuberculosis (MDR-TB), and non-tuberculosis mycobacteria infections (NTM). A cross-sectional study was conducted between 2014 and 2022, comprising 1073 patients who were recruited from chest department clinic in a tertial refer hospital in Taipei City, Taiwan. Ambient 1-, 7-, and 30-day PM2...
March 5, 2024: Science of the Total Environment
https://read.qxmd.com/read/38450334/factors-influencing-histoplasmosis-incidence-in-multidrug-resistant-pulmonary-tuberculosis-patients-a-cross-sectional-study-in-indonesia
#19
JOURNAL ARTICLE
Selfi Khairunnisa, Noni N Soeroso, Muntasir Abdullah, Lambok Siahaan, Putri C Eyanoer, Elvita R Daulay, Retno Wahyuningsih, David W Denning
Histoplasmosis is an infectious disease caused by the dimorphic fungus Histoplasma capsulatum , which in chronic conditions, is generally difficult to distinguish from pulmonary tuberculosis (TB) based on its clinical appearance; therefore, diagnostic errors could occur. Meanwhile, the prevalence of multidrug-resistant pulmonary TB (MDR-TB) in Indonesia remains high. Study determining the incidence of histoplasmosis in MDR-TB is unavailable worldwide. The aim of this study was to determine the risk factors of histoplasmosis incidence in MDR-TB patients in Indonesia...
December 2023: Narra J
https://read.qxmd.com/read/38450276/risk-factors-of-mdr-tb-and-impacts-of-covid-19-pandemic-on-escalating-of-mdr-tb-incidence-in-lower-middle-income-countries-a-scoping-review
#20
JOURNAL ARTICLE
Ichsan Ichsan, Lynda Redwood-Campbell, Nissa N Mahmud, Herlina Dimiati, Muhammad Yani, Mudatsir Mudatsir, Maimun Syukri
The coronavirus disease 2019 (COVID-19) pandemic is affecting tuberculosis (TB) treatment in many ways that might lead to increasing the prevalence of multi-drugs-resistance tuberculosis (MDR-TB), especially in lower-middle-income-countries (LMICs). This scoping review aimed to identify the risk factors of MDR-TB and to determine the impacts of the COVID-19 pandemic on MDR-TB prevalence in LMICs. This study was reported according to the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR) guideline...
August 2023: Narra J
keyword
keyword
84503
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.