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Ismail Kocyigit, Eray Eroglu, Ahmet Safa Kaynar, Derya Kocer, Seval Kargi, Gokmen Zararsiz, Ruslan Bayramov, Hakan Imamoglu, Murat Hayri Sipahioglu, Bulent Tokgoz, Munis Dundar, Oktay Oymak
BACKGROUND: The prominent features of autosomal dominant polycystic kidney disease (ADPKD) are early development of hypertension, chronic kidney disease and cardiovascular problems. Thus, we aimed to investigate the role of endothelin, a vascular biomarker, in the clinical course of ADPKD, including renal and cardiovascular survival. METHODS: In 138 patients with ADPKD and 28 healthy controls, we measured serum endothelin-1 (ET-1) levels by enzyme-linked immunosorbent assay (ELISA)...
July 18, 2018: Journal of Nephrology
Medi Kori, Kazim Yalcin Arga
The malignant neoplasm of the cervix, cervical cancer, has effects on the reproductive tract. Although infection with oncogenic human papillomavirus is essential for cervical cancer development, it alone is insufficient to explain the development of cervical cancer. Therefore, other risk factors such as host genetic factors should be identified, and their importance in cervical cancer induction should be determined. Although gene expression profiling studies in the last decade have made significant molecular findings about cervical cancer, adequate screening and effective treatment strategies have yet to be achieved...
2018: PloS One
Carolina Vidal, Carina Ruano, Vera Bernardino, Pedro Lavado Carreira, Ana Lladó, Maria Céu Santos, Heidi Gruner, António Panarra, Nuno Riso, Maria Francisca Moraes-Fontes
INTRODUCTION: Systemic sclerosis is a complex disorder that requires systematic screening. Our objective is to report the European Scleroderma Trials and Research group centre affiliation and its impact in our clinical practice. MATERIAL AND METHODS: The European Scleroderma Trials and Research group affiliation process, database update and current patient evaluation, with respect to demographic and clinical features. Cumulative mortality was analysed. RESULTS: We identified 19 female patients (which met all the American College of Rheumatology/ European League Against Rheumatism 2013 criteria for systemic sclerosis) under current follow-up, divided according to the LeRoy classification into diffuse cutaneous (n = 5), limited cutaneous (n = 11) and limited (n = 3) types, followed for a median period of 5, 12 and 6 years, respectively...
June 29, 2018: Acta Médica Portuguesa
Matías Hernández, Susana Wicz, Miguel H Santamaría, Ricardo S Corral
BACKGROUND: The anti-inflammatory and cardioprotective properties of curcumin (Cur), a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa, are increasingly considered to have beneficial effects on the progression of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi. OBJECTIVE: To evaluate the effects of oral therapy with Cur on T. cruzi-mediated cardiovasculopathy in acutely infected mice and analyse the in vitro response of parasite-infected human microvascular endothelial cells treated with this phytochemical...
July 16, 2018: Memórias do Instituto Oswaldo Cruz
Rachael Morris, Shauna-Kay Spencer, Allison Barnes, Teylor Bowles, Patrick B Kyle, Kedra Wallace
HELLP (hemolysis elevated liver enzyme low platelet) syndrome is associated with hypertension, inflammation, oxidative stress and endothelial activation. The objective of this study was to determine if oxygen scavenging or endothelin A receptor antagonism improved hypertension and oxidative stress. sFlt-1 and sEndoglin were infused via mini-osmotic pump into normal pregnant rats (NP) on gestational day 12 to create HELLP syndrome. On gestational day 18 arterial catheters were inserted and on gestational day 19 mean arterial pressure was analyzed in rats; serum, urine and tissues were collected for molecular analysis...
July 13, 2018: European Journal of Pharmacology
Matthew Jankowich, Beth Elston, Qing Liu, Siddique Abbasi, Wen-Chih Wu, Chad Blackshear, Mark Godfrey, Gaurav Choudhary
RATIONALE: Although COPD has been related to heart failure, the relationship between the restrictive spirometry pattern (FVC<80% predicted with preserved FEV1/FVC ratio) and heart failure is poorly understood. OBJECTIVE: To determine whether having a restrictive spirometry pattern is associated with incident heart failure hospitalization. METHODS: Community-dwelling African-Americans from the Jackson Heart Study (total n=5,306; analyzed n=4,210 with spirometry and heart failure outcome data) were grouped by restrictive (FEV1/FVC≥0...
July 16, 2018: Annals of the American Thoracic Society
Yan Sun, Tiezhu Ma, Chong Chen, Sai Zhang
OBJECTIVE: To observe the therapeutic effect of combined acupuncture combined with omeprazole on patients with craniocerebral trauma complicated with stress gastric mucosal injury. METHODS: Patients with stress gastric mucosal injury after cerebral trauma admitted to neurology of Brain Hospital, Affiliated Hospital of Logistics University from June 2016 to July 2017 were enrolled, with the inclusion criteria within 24 hours after injury at admission, and Glasgow coma scale (GCS) less than 12...
June 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Jinjin Cui, Fengyun Zhang, Wei Cao, Yongshun Wang, Jingjin Liu, Xinxin Liu, Tao Chen, Ling Li, Jinwei Tian, Bo Yu
BACKGROUND: Erythropoietin (EPO), which is clinically used for renal anaemia, reportedly exerts beneficial pleiotropic effects in atherosclerosis. This aim of this study was to investigate the effects of EPO on macrophage inflammation and polarization under hyperglycaemic conditions and to identify the effects of EPO-treated macrophage supernatants (SNs) on endothelial cell (EC) function. METHODS: Peritoneal macrophages (pMΦs) were isolated from normal, diabetic or EPO-injected mice...
July 11, 2018: Molecular Immunology
Elisabetta Zanatta, Pamela Polito, Mariangela Favaro, Maddalena Larosa, Piero Marson, Franco Cozzi, Andrea Doria
Scleroderma renal crisis (SRC) is an uncommon but still life-threatening manifestation of systemic sclerosis (SSc). The incidence of SRC has decreased in the last few decades, probably due to a widespread use of vasodilators in SSc patients. It is well-recognized that exposure to different drugs can trigger SRC (corticosteroids, cyclosporine) or prevent its occurrence (iloprost, calcium channel blockers). The prognosis of this life-threatening manifestation has not substantially improved since 1980s, when ACE-inhibitors were introduced in its treatment...
July 10, 2018: Autoimmunity Reviews
Joaquim Blanch, Marcel Egger
Augmented inositol 1,4,5-trisphosphate (IP3 ) receptor (IP3 R2) function has been linked to a variety of cardiac pathologies including cardiac arrhythmias. The functional role of IP3 -induced Ca2+ release (IP3 ICR) within ventricular excitation-contraction coupling (ECC) remains elusive. As part of pathophysiological cellular remodelling, IP3 R2s are overexpressed and have been repeatedly linked to enhanced Ca2+ -dependent arrhythmogenicity. In this study we test the hypothesis that an opposite scenario might be plausible in which IP3 ICR is part of an ECC protecting mechanism, resulting in a Ca2+ -dependent anti-arrhythmogenic response on the cellular scale...
July 13, 2018: Journal of Physiology
Kelly N Sebzda, Andrew V Kuczmarski, Ryan T Pohlig, Shannon L Lennon, David G Edwards, Megan M Wenner
OBJECTIVE: We recently demonstrated endothelin-B receptors (ETBR ) mediate vasodilation in young but not postmenopausal women; it is unclear if this is related to age or a decline in ovarian hormones. The purpose of this study was to test the hypothesis that ETBR responses are modulated by ovarian hormones. METHODS: We measured cutaneous vasodilatory responses in 12 young women (22±1 years, 23±1 kg/m2 ) during the mid-luteal (ML; days 20-25) and early follicular (EF; days 2-5) phases of the menstrual cycle...
July 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Stavroula C Koukoula, Andreas Katsanos, Ioannis K Tentes, Georgios Labiris, Vassilios P Kozobolis
Background: Endothelin-1 (ET-1) is the most potent vasoconstrictor in the body. There are reports in the literature correlating plasma levels of ET-1 and its impact on retrobulbar hemodynamics. This study evaluates aqueous humor levels of ET-1 and retrobulbar hemodynamics in patients with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG). Patients and methods: Patients scheduled for cataract surgery were included. Patients were allocated to non-exfoliation non-glaucoma group (controls), XFG and XFS groups...
2018: Clinical Ophthalmology
Juan Zhang, Wen-Shu Zhao, Xin Wang, Lin Xu, Xin-Chun Yang
OBJECTIVE: We investigated the regulation of endothelin-1 (ET-1) expression in in vivo high-fat diet (HFD)-fed mice and in vitro cultured human aortic endothelial cells (HAECs). METHODS: Male C57BL/6 mice were fed on standard chow, serum was prepared, and ET-1 levels were analyzed using an ELISA kit. Quantitative PCR was performed using iQ SYBR Green Supermix. Statistical significance was assessed using SPSS, with p < 0.05 considered significant. RESULTS: The serum ET-1 content and endothelial expression of ET-1 mRNA were increased in the HFD-fed mice compared to the chow-fed control mice...
July 11, 2018: Cardiology
Lukas Andreas Heger, Mark Kerber, Marcus Hortmann, Samuel Robinson, Maximilian Mauler, Daniela Stallmann, Daniel Duerschmied, Christoph Bode, Christoph Hehrlein, Ingo Ahrens
Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer transcription factor consisting of 2 subunits, HIF-1α and HIF-1β. Hypoxia-dependent activation of HIF-1α regulates cellular O2 homeostasis. Raynaud syndrome (RS), as a comorbidity of the autoimmune disease systemic sclerosis (SS), is characterized by vasospasms that limit blood flow to the limbs, resulting in hypoxia. A single-center randomized study was conducted to compare prostaglandin E1 (PgE1) therapy with a treatment combining PgE1 and an endothelin-1 blocker, bosentan...
July 10, 2018: Acta Pharmacologica Sinica
Hesham Y A Darwish, Yuanyuan Zhang, Kai Cui, Zu Yang, Deping Han, Xianggui Dong, Huaming Mao, Weidong Deng, Xuemei Deng
Background: Black bone sheep was first discovered in Yunnan province of China in 1970, with unique black pigmentation on the body and internal organs. Endothelin 3 ( EDN3 ) has been known as a key gene causing hyperpigmentation in black bone chicken, the Silky fowl. Methods: In this study, EDN3 was employed as a candidate gene for regulating black color pigmentation. First, EDN3 was cloned from sheep to obtain the full-length cDNA by using the rapid amplification of cDNA ends (RACE)...
2018: Journal of Animal Science and Biotechnology
M G Ahlström, A Knudsen, H Ullum, J Gerstoft, A Kjaer, A-M Lebech, P Hasbak, N Obel
OBJECTIVES: Smoking is a major contributor to mortality and morbidity in HIV-positive individuals. Our primary objective was to evaluate the association between smoking status determined by plasma cotinine (P-cotinine) concentration and inflammatory and endothelial biomarkers in HIV-positive versus HIV-negative individuals. METHODS: We studied eight inflammatory/endothelial biomarkers [high-sensitivity C-reactive protein (hsCRP), E-selectin, soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble intercellular adhesion molecule 1 (sICAM-1), matrix metallopeptidase 9 (MMP-9), myeloperoxidase (MPO), tissue type plasminogen activator inhibitor 1 (tPAI) and endothelin] in 105 HIV-positive individuals and 105 HIV-negative individuals matched on age, sex and self-reported smoking status...
July 9, 2018: HIV Medicine
Alain Meyrier, Patrick Niaudet
Minimal change disease accounts for 70% to 90% of cases of nephrotic syndrome in children. It also causes nephrotic syndrome in adults, including patients older than age 60. Renal function is altered moderately in approximately 20% to 30% of patients because foot-process fusion impairs filtration of water and solutes. The glomerular filtration rate is reduced by approximately 20% to 30% and returns to baseline with remission of proteinuria. Over the past 50 years, a number of publications have reported cases of acute kidney injury occurring in approximately one-fifth to one-third of adult cases in the absence of prior or concomitant renal disease...
July 3, 2018: Kidney International
Simon Lambden, Ben C Creagh-Brown, Julie Hunt, Charlotte Summers, Lui G Forni
Vasoplegia is the syndrome of pathological low systemic vascular resistance, the dominant clinical feature of which is reduced blood pressure in the presence of a normal or raised cardiac output. The vasoplegic syndrome is encountered in many clinical scenarios, including septic shock, post-cardiac bypass and after surgery, burns and trauma, but despite this, uniform clinical definitions are lacking, which renders translational research in this area challenging. We discuss the role of vasoplegia in these contexts and the criteria that are used to describe it are discussed...
July 6, 2018: Critical Care: the Official Journal of the Critical Care Forum
Enny-Sonia Xu, Muh-Hwa Yang, Shih-Che Huang, Chih-Yi Liu, Ting-Ting Yang, Teh-Ying Chou, Tzer-Zen Hwang, Chao-Tien Hsu
BACKGROUND: Endothelin-converting enzyme-1 (ECE-1) primarily converts Big Endothelins (ETs) into active Endothelin-1 (ET-1). However, the expression pattern and prognostication status of ECE-1 in head and neck cancer (HNC) are enigmatic. In this study, we investigated ECE-1 expression and assessed the roles of ECE-1 as a predictor for HNC differentiation and prognosis. MATERIAL AND METHODS: ECE-1 expressions were evaluated by immunohistochemical analysis using a tissue microarray (TMA) composed of 100 cases of head and neck squamous cell carcinoma...
July 6, 2018: Oral Diseases
Zhi-Jian Liu, Gao-Pin Hu, Mei-Ying Fei, Zao Yin, Quan-Xing Shi, Fei Sun
Objects The aim of this trial was to evaluate the effect of short-term high-dose atorvastatin therapy on levels of high-sensitivity C-reactive protein (hs-CRP), malonaldehyde (MDA), endothelin-1(ET-1), matrix metalloproteinases (MMPs), and left ventricular (LV) remodeling in patients with first time attack of acute anterior myocardial infarction (AAMI) .Methods A hundred and three patients with first time attack of AAMI who underwent successful primary percutaneous coronary intervention were randomized to receive atorvastatin 40 mg once daily for 1 week followed by 20 mg once daily (intensive treatment group, IT group, n=49), or atorvastatin 20 mg once daily (standard treatment group, ST group, n=54)...
June 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
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