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Acetaminophen in fever children

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https://www.readbyqxmd.com/read/27872357/antipyretic-efficacy-and-safety-of-ibuprofen-versus-acetaminophen-suspension-in-febrile-children-results-of-2-randomized-double-blind-single-dose-studies
#1
Shyamalie Jayawardena, David Kellstein
Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7.5 mg/kg or acetaminophen (APAP) suspension 10 to 15 mg/kg. The primary efficacy parameter was time-weighted sum of temperature differences (TWSTD) from baseline through 8 hours for each study. Secondary end points included TWSTD from baseline through 6 hours, time to onset and duration of temperature control, and proportion with temperature control. Studies were pooled for post hoc analyses of efficacy and adverse event end points...
November 20, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27798399/parental-approach-to-the-prevention-and-management-of-fever-and-pain-following-childhood-immunizations-a-survey-study
#2
Ezzeldin Saleh, Geeta K Swamy, M Anthony Moody, Emmanuel B Walter
Antipyretic analgesics are commonly used to prevent and treat adverse events following immunizations. Current practice discourages routine use due to possible blunting of vaccine immune responses. We surveyed 150 parents/caregivers of recently vaccinated 6- and 15-month-old children to determine the prevalence of and beliefs regarding antipyretic analgesics use around vaccinations. 11% used them prophylactically, before vaccination. Use in the first 48 hours after vaccination was 64%, primarily to prevent and/or treat fever and pain...
October 23, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27794128/association-of-acetaminophen-and-ibuprofen-use-with-wheezing-in-children-with-acute-febrile-illness
#3
Ilan Matok, Arnon Elizur, Amichai Perlman, Shani Ganor, Hagai Levine, Eran Kozer
BACKGROUND: Many infants and children receive acetaminophen and/or ibuprofen during febrile illness. Previously, some studies have linked acetaminophen and ibuprofen use to wheezing and exacerbation of asthma symptoms in infants and children. OBJECTIVE: To assess whether acetaminophen or ibuprofen use are associated with wheezing in children presenting to the emergency department (ED) with febrile illness. METHODS: This was a cross-sectional study of children who presented with fever to the pediatric ED between 2009 and 2013...
October 27, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27695658/acetaminophen-use-for-fever-in-children-associated-with-autism-spectrum-disorder
#4
Stephen T Schultz, Georgianna G Gould
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12-18 months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08-33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs...
April 2016: Autism-open Access
https://www.readbyqxmd.com/read/27532828/acetaminophen-versus-ibuprofen-in-young-children-with-mild-persistent-asthma
#5
RANDOMIZED CONTROLLED TRIAL
William J Sheehan, David T Mauger, Ian M Paul, James N Moy, Susan J Boehmer, Stanley J Szefler, Anne M Fitzpatrick, Daniel J Jackson, Leonard B Bacharier, Michael D Cabana, Ronina Covar, Fernando Holguin, Robert F Lemanske, Fernando D Martinez, Jacqueline A Pongracic, Avraham Beigelman, Sachin N Baxi, Mindy Benson, Kathryn Blake, James F Chmiel, Cori L Daines, Michael O Daines, Jonathan M Gaffin, Deborah A Gentile, W Adam Gower, Elliot Israel, Harsha V Kumar, Jason E Lang, Stephen C Lazarus, John J Lima, Ngoc Ly, Jyothi Marbin, Wayne J Morgan, Ross E Myers, J Tod Olin, Stephen P Peters, Hengameh H Raissy, Rachel G Robison, Kristie Ross, Christine A Sorkness, Shannon M Thyne, Michael E Wechsler, Wanda Phipatanakul
BACKGROUND: Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking. METHODS: In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks...
August 18, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27479646/prenatal-use-of-acetaminophen-and-child-iq-a-danish-cohort-study
#6
Zeyan Liew, Beate Ritz, Jasveer Virk, Onyebuchi A Arah, Jørn Olsen
BACKGROUND: Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy, and recently has been linked to hyperactivity and behavioral problems in children. We examine whether prenatal use of acetaminophen affects children's intelligence quotient (IQ). METHODS: We studied 1,491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Acetaminophen use in pregnancy was prospectively recorded in three telephone interviews...
November 2016: Epidemiology
https://www.readbyqxmd.com/read/27401931/risk-factors-for-local-complications-in-children-with-community-acquired-pneumonia
#7
Katarzyna Krenke, Marta Krawiec, Grażyna Kraj, Joanna Peradzynska, Agnieszka Krauze, Marek Kulus
AIM: The aim of this study was to evaluate the factors that could predict the development of local complications (parapneumonic effusion/pleural empyema, necrotizing pneumonia, and lung abscess) in children with community-acquired pneumonia (CAP). METHODS: Demographic, clinical, and laboratory data were prospectively collected and compared in children with noncomplicated and complicated CAP. RESULTS: Two-hundred and three patients aged from 2 months to 17 years were enrolled...
July 12, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27386721/common-questions-about-streptococcal-pharyngitis
#8
Monica G Kalra, Kim E Higgins, Evan D Perez
Group A beta-hemolytic streptococcal (GABHS) infection causes 15% to 30% of sore throats in children and 5% to 15% in adults, and is more common in the late winter and early spring. The strongest independent predictors of GABHS pharyngitis are patient age of five to 15 years, absence of cough, tender anterior cervical adenopathy, tonsillar exudates, and fever. To diagnose GABHS pharyngitis, a rapid antigen detection test should be ordered in patients with a modified Centor or FeverPAIN score of 2 or 3. First-line treatment for GABHS pharyngitis includes a 10-day course of penicillin or amoxicillin...
July 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27275268/fulminate-hepatic-failure-in-a-5-year-old-female-after-inappropriate-acetaminophen-treatment
#9
Irena Kasmi, Sashenka Sallabanda, Gentian Kasmi
BACKGROUND: Acetaminophen is a drug widely used in children because of its safety and efficacy. Although the risk of its toxicity is lower in children such reactions occur in pediatric patients from intentional overdoses and less frequently attributable to unintended inappropriate dosing. The aim of reporting this case is to attract the attention to the risk of the acetaminophen toxicity when administered in high doses. CASE PRESENTATION: We report here a 5 year old girl who developed fulminate liver failure with renal impairment and acute pancreatitis, as a result of acetaminophen toxicity caused from unintentional repeated supratherapeutic ingestion, with a total administered dose of 4800 mg in three consecutive days, 1600 mg/day, approximately 90 mg/kg/day...
September 15, 2015: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27193104/enduring-large-use-of-acetaminophen-suppositories-for-fever-management-in-children-a-national-survey-of-french-parents-and-healthcare-professionals-practices
#10
Nathalie Bertille, Elisabeth Fournier-Charrière, Gérard Pons, Babak Khoshnood, Martin Chalumeau
UNLABELLED: The pharmacological specificities of the rectal formulation of acetaminophen led to a debate on its appropriateness for managing fever in children, but few data are available on the formulation's current use and determinants of use. In a national cross-sectional study between 2007 and 2008, healthcare professionals were asked to include five consecutive patients with acute fever. Among the 6255 children (mean age 4.0 years ± 2.8 SD) who received acetaminophen given by parents or prescribed/recommended by healthcare professionals, determinants of suppository use were studied by multilevel models...
July 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27118212/pharmacokinetic-properties-of-intramuscular-versus-oral-syrup-paracetamol-in-plasmodium-falciparum-malaria
#11
Thanaporn Wattanakul, Pramote Teerapong, Katherine Plewes, Paul N Newton, Wirongrong Chierakul, Kamolrat Silamut, Kesinee Chotivanich, Ronnatrai Ruengweerayut, Nicholas J White, Arjen M Dondorp, Joel Tarning
BACKGROUND: Fever is an inherent symptom of malaria in both adults and children. Paracetamol (acetaminophen) is the recommended antipyretic as it is inexpensive, widely available and has a good safety profile, but patients may not be able to take the oral drug reliably. A comparison between the pharmacokinetics of oral syrup and intramuscular paracetamol given to patients with acute falciparum malaria and high body temperature was performed. METHODS: A randomized, open-label, two-treatment, crossover, pharmacokinetic study of paracetamol dosed orally and intramuscularly was conducted...
2016: Malaria Journal
https://www.readbyqxmd.com/read/26920747/acetaminophen-administration-in-pediatric-age-an-observational-prospective-cross-sectional-study
#12
Riccardo Lubrano, Sara Paoli, Marco Bonci, Luigi Di Ruzza, Corrado Cecchetti, Raffaele Falsaperla, Piero Pavone, Nassim Matin, Giovanna Vitaliti, Isotta Gentile
BACKGROUND: Parents often do not consider fever as an important physiological response and mechanism of defense against infections that leads to inappropriate use of antipyretics and potentially dangerous side effects. This study is designed to evaluate the appropriateness of antipyretics dosages generally administered to children with fever, and to identify factors that may influence dosage accuracy. RESULTS: In this cross-sectional study we analyzed the clinical records of 1397 children aged >1 month and < 16 years, requiring a primary care (ambulatory) outpatient visit due to fever...
February 26, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/26688372/maternal-use-of-acetaminophen-during-pregnancy-and-risk-of-autism-spectrum-disorders-in-childhood-a-danish-national-birth-cohort-study
#13
Zeyan Liew, Beate Ritz, Jasveer Virk, Jørn Olsen
Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996-2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring...
September 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/26254283/prenatal-acetaminophen-affects-maternal-immune-and-endocrine-adaptation-to-pregnancy-induces-placental-damage-and-impairs-fetal-development-in-mice
#14
Kristin Thiele, M Emilia Solano, Samuel Huber, Richard A Flavell, Timo Kessler, Roja Barikbin, Roman Jung, Khalil Karimi, Gisa Tiegs, Petra C Arck
Acetaminophen (APAP; ie, Paracetamol or Tylenol) is generally self-medicated to treat fever or pain and recommended to pregnant women by their physicians. Recent epidemiological studies reveal an association between prenatal APAP use and an increased risk for asthma. Our aim was to identify the effects of APAP in pregnancy using a mouse model. Allogeneically mated C57Bl/6J females were injected i.p. with 50 or 250 mg/kg APAP or phosphate-buffered saline on gestation day 12.5; nonpregnant females served as controls...
October 2015: American Journal of Pathology
https://www.readbyqxmd.com/read/25897106/intentional-and-accidental-paracetamol-poisoning-in-childhood-a-retrospective-analysis
#15
Katarzyna Kominek, Agnieszka Pawłowska-Kamieniak, Agnieszka Mroczkowska-Juchkiewicz, Paulina Krawiec, Elżbieta Pac-Kożuchowska
INTRODUCTION: Paracetamol is one of the most commonly used analgesics and antipyretics available without limits as preparations of the OTC group (over the counter drugs). Overdose and poisoning with this drug always brings about the risk of acute hepatic failure. The objective of the study was a retrospective evaluation of patients hospitalized in the Paediatric Clinic during the period 2004-2012 due to poisoning with paracetamol. MATERIAL AND METHODS: The analysis covered 44 patients hospitalized in the Paediatric Clinic during 2004-2012 due to poisoning with paracetamol...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/25868963/severe-intrinsic-acute-kidney-injury-associated-with-therapeutic-doses-of-acetaminophen
#16
Tatsuya Ito, Shojiro Watanabe, Kazushi Tsuruga, Tomomi Aizawa, Koji Hirono, Etsuro Ito, Kensuke Joh, Hiroshi Tanaka
Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages. Recently, we encountered the case of a 3-year-old Japanese girl who suffered from severe intrinsic acute kidney injury (AKI) after therapeutic doses of acetaminophen for a fever due to viral infection. Renal biopsy indicated severe acute tubular necrosis with a significant striped interstitial fibrosis and mild interstitial inflammation...
April 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/25851072/use-of-paracetamol-during-pregnancy-and-child-neurological-development
#17
REVIEW
Laurence de Fays, Karen Van Malderen, Karen De Smet, Javier Sawchik, Veerle Verlinden, Jamila Hamdani, Jean-Michel Dogné, Bernard Dan
Paracetamol (acetaminophen) remains the first line for the treatment of pain and fever in pregnancy. Recently published epidemiological studies suggested a possible association between paracetamol exposure in utero and attention-deficit-hyperactivity disorder/hyperkinetic disorder (ADHD/HKD) or adverse development issues in children. However, the effects observed are in the weak to moderate range, and limitations in the studies' design prevent inference on a causal association with ADHD/HKD or child neurological development...
August 2015: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/25759881/-also-ibuprofen-not-just-paracetamol-can-cause-serious-liver-damage-in-children-nsaids-should-be-used-with-caution-in-children-as-shown-in-case-with-fatal-outcome
#18
Henrietta Norman, Marta Elfineh, Eva Beijer, Thomas Casswall, Antal Németh
No abstract text is available yet for this article.
October 1, 2014: Läkartidningen
https://www.readbyqxmd.com/read/25693262/acetaminophen-children-why-have-pediatric-dosage-guidelines-changed-and-what-does-it-mean-in-practice
#19
Carolyn Knox, Eva Selker
No abstract text is available yet for this article.
December 2011: Advance for NPs & PAs
https://www.readbyqxmd.com/read/25533249/-management-of-fever-in-children
#20
REVIEW
Anna Pirker, Matthias Pirker
Fever is one of the most common reasons for encounter in pediatrics. This article gives information on how to judge the condition of a feverish child or infant correctly: Special emphasis should be put on the general condition of the patient and the clinical course of symptoms over time. With a few skills and tools severe pitfalls can be avoided. General practitioners administer antibiotics in febrile children more often than pediatricians do. The decision of giving antibiotics in an ambulatory setting should not exclusively be based on elevated inflammatory markers in the blood without a sufficient clinical proof of bacterial infection...
January 2015: Therapeutische Umschau. Revue Thérapeutique
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