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Acetaminophen in fever children

Stephen T Schultz, Georgianna G Gould
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12-18 months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08-33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs...
April 2016: Autism-open Access
William J Sheehan, David T Mauger, Ian M Paul, James N Moy, Susan J Boehmer, Stanley J Szefler, Anne M Fitzpatrick, Daniel J Jackson, Leonard B Bacharier, Michael D Cabana, Ronina Covar, Fernando Holguin, Robert F Lemanske, Fernando D Martinez, Jacqueline A Pongracic, Avraham Beigelman, Sachin N Baxi, Mindy Benson, Kathryn Blake, James F Chmiel, Cori L Daines, Michael O Daines, Jonathan M Gaffin, Deborah A Gentile, W Adam Gower, Elliot Israel, Harsha V Kumar, Jason E Lang, Stephen C Lazarus, John J Lima, Ngoc Ly, Jyothi Marbin, Wayne J Morgan, Ross E Myers, J Tod Olin, Stephen P Peters, Hengameh H Raissy, Rachel G Robison, Kristie Ross, Christine A Sorkness, Shannon M Thyne, Michael E Wechsler, Wanda Phipatanakul
BACKGROUND: Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking. METHODS: In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks...
August 18, 2016: New England Journal of Medicine
Zeyan Liew, Beate Ritz, Jasveer Virk, Onyebuchi A Arah, Jørn Olsen
BACKGROUND: Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy, and recently has been linked to hyperactivity and behavioral problems in children. We examine whether prenatal use of acetaminophen affects children's intelligence quotient (IQ). METHODS: We studied 1,491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Acetaminophen use in pregnancy was prospectively recorded in three telephone interviews...
November 2016: Epidemiology
Katarzyna Krenke, Marta Krawiec, Grażyna Kraj, Joanna Peradzynska, Agnieszka Krauze, Marek Kulus
AIM: The aim of this study was to evaluate the factors that could predict the development of local complications (parapneumonic effusion/pleural empyema, necrotizing pneumonia, and lung abscess) in children with community-acquired pneumonia (CAP). METHODS: Demographic, clinical, and laboratory data were prospectively collected and compared in children with noncomplicated and complicated CAP. RESULTS: Two-hundred and three patients aged from 2 months to 17 years were enrolled...
July 12, 2016: Clinical Respiratory Journal
Monica G Kalra, Kim E Higgins, Evan D Perez
Group A beta-hemolytic streptococcal (GABHS) infection causes 15% to 30% of sore throats in children and 5% to 15% in adults, and is more common in the late winter and early spring. The strongest independent predictors of GABHS pharyngitis are patient age of five to 15 years, absence of cough, tender anterior cervical adenopathy, tonsillar exudates, and fever. To diagnose GABHS pharyngitis, a rapid antigen detection test should be ordered in patients with a modified Centor or FeverPAIN score of 2 or 3. First-line treatment for GABHS pharyngitis includes a 10-day course of penicillin or amoxicillin...
July 1, 2016: American Family Physician
Irena Kasmi, Sashenka Sallabanda, Gentian Kasmi
BACKGROUND: Acetaminophen is a drug widely used in children because of its safety and efficacy. Although the risk of its toxicity is lower in children such reactions occur in pediatric patients from intentional overdoses and less frequently attributable to unintended inappropriate dosing. The aim of reporting this case is to attract the attention to the risk of the acetaminophen toxicity when administered in high doses. CASE PRESENTATION: We report here a 5 year old girl who developed fulminate liver failure with renal impairment and acute pancreatitis, as a result of acetaminophen toxicity caused from unintentional repeated supratherapeutic ingestion, with a total administered dose of 4800 mg in three consecutive days, 1600 mg/day, approximately 90 mg/kg/day...
September 15, 2015: Open Access Macedonian Journal of Medical Sciences
Nathalie Bertille, Elisabeth Fournier-Charrière, Gérard Pons, Babak Khoshnood, Martin Chalumeau
UNLABELLED: The pharmacological specificities of the rectal formulation of acetaminophen led to a debate on its appropriateness for managing fever in children, but few data are available on the formulation's current use and determinants of use. In a national cross-sectional study between 2007 and 2008, healthcare professionals were asked to include five consecutive patients with acute fever. Among the 6255 children (mean age 4.0 years ± 2.8 SD) who received acetaminophen given by parents or prescribed/recommended by healthcare professionals, determinants of suppository use were studied by multilevel models...
July 2016: European Journal of Pediatrics
Thanaporn Wattanakul, Pramote Teerapong, Katherine Plewes, Paul N Newton, Wirongrong Chierakul, Kamolrat Silamut, Kesinee Chotivanich, Ronnatrai Ruengweerayut, Nicholas J White, Arjen M Dondorp, Joel Tarning
BACKGROUND: Fever is an inherent symptom of malaria in both adults and children. Paracetamol (acetaminophen) is the recommended antipyretic as it is inexpensive, widely available and has a good safety profile, but patients may not be able to take the oral drug reliably. A comparison between the pharmacokinetics of oral syrup and intramuscular paracetamol given to patients with acute falciparum malaria and high body temperature was performed. METHODS: A randomized, open-label, two-treatment, crossover, pharmacokinetic study of paracetamol dosed orally and intramuscularly was conducted...
2016: Malaria Journal
Riccardo Lubrano, Sara Paoli, Marco Bonci, Luigi Di Ruzza, Corrado Cecchetti, Raffaele Falsaperla, Piero Pavone, Nassim Matin, Giovanna Vitaliti, Isotta Gentile
BACKGROUND: Parents often do not consider fever as an important physiological response and mechanism of defense against infections that leads to inappropriate use of antipyretics and potentially dangerous side effects. This study is designed to evaluate the appropriateness of antipyretics dosages generally administered to children with fever, and to identify factors that may influence dosage accuracy. RESULTS: In this cross-sectional study we analyzed the clinical records of 1397 children aged >1 month and < 16 years, requiring a primary care (ambulatory) outpatient visit due to fever...
2016: Italian Journal of Pediatrics
Zeyan Liew, Beate Ritz, Jasveer Virk, Jørn Olsen
Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996-2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring...
September 2016: Autism Research: Official Journal of the International Society for Autism Research
Kristin Thiele, M Emilia Solano, Samuel Huber, Richard A Flavell, Timo Kessler, Roja Barikbin, Roman Jung, Khalil Karimi, Gisa Tiegs, Petra C Arck
Acetaminophen (APAP; ie, Paracetamol or Tylenol) is generally self-medicated to treat fever or pain and recommended to pregnant women by their physicians. Recent epidemiological studies reveal an association between prenatal APAP use and an increased risk for asthma. Our aim was to identify the effects of APAP in pregnancy using a mouse model. Allogeneically mated C57Bl/6J females were injected i.p. with 50 or 250 mg/kg APAP or phosphate-buffered saline on gestation day 12.5; nonpregnant females served as controls...
October 2015: American Journal of Pathology
Katarzyna Kominek, Agnieszka Pawłowska-Kamieniak, Agnieszka Mroczkowska-Juchkiewicz, Paulina Krawiec, Elżbieta Pac-Kożuchowska
INTRODUCTION: Paracetamol is one of the most commonly used analgesics and antipyretics available without limits as preparations of the OTC group (over the counter drugs). Overdose and poisoning with this drug always brings about the risk of acute hepatic failure. The objective of the study was a retrospective evaluation of patients hospitalized in the Paediatric Clinic during the period 2004-2012 due to poisoning with paracetamol. MATERIAL AND METHODS: The analysis covered 44 patients hospitalized in the Paediatric Clinic during 2004-2012 due to poisoning with paracetamol...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
Tatsuya Ito, Shojiro Watanabe, Kazushi Tsuruga, Tomomi Aizawa, Koji Hirono, Etsuro Ito, Kensuke Joh, Hiroshi Tanaka
Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages. Recently, we encountered the case of a 3-year-old Japanese girl who suffered from severe intrinsic acute kidney injury (AKI) after therapeutic doses of acetaminophen for a fever due to viral infection. Renal biopsy indicated severe acute tubular necrosis with a significant striped interstitial fibrosis and mild interstitial inflammation...
April 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
Laurence de Fays, Karen Van Malderen, Karen De Smet, Javier Sawchik, Veerle Verlinden, Jamila Hamdani, Jean-Michel Dogné, Bernard Dan
Paracetamol (acetaminophen) remains the first line for the treatment of pain and fever in pregnancy. Recently published epidemiological studies suggested a possible association between paracetamol exposure in utero and attention-deficit-hyperactivity disorder/hyperkinetic disorder (ADHD/HKD) or adverse development issues in children. However, the effects observed are in the weak to moderate range, and limitations in the studies' design prevent inference on a causal association with ADHD/HKD or child neurological development...
August 2015: Developmental Medicine and Child Neurology
Henrietta Norman, Marta Elfineh, Eva Beijer, Thomas Casswall, Antal Németh
No abstract text is available yet for this article.
October 1, 2014: Läkartidningen
Carolyn Knox, Eva Selker
No abstract text is available yet for this article.
December 2011: Advance for NPs & PAs
Anna Pirker, Matthias Pirker
Fever is one of the most common reasons for encounter in pediatrics. This article gives information on how to judge the condition of a feverish child or infant correctly: Special emphasis should be put on the general condition of the patient and the clinical course of symptoms over time. With a few skills and tools severe pitfalls can be avoided. General practitioners administer antibiotics in febrile children more often than pediatricians do. The decision of giving antibiotics in an ambulatory setting should not exclusively be based on elevated inflammatory markers in the blood without a sufficient clinical proof of bacterial infection...
January 2015: Therapeutische Umschau. Revue Thérapeutique
Khalil Karimi, Timo Keßler, Kristin Thiele, Katherina Ramisch, Annette Erhardt, Peter Huebener, Roja Barikbin, Petra Arck, Gisa Tiegs
BACKGROUND & AIMS: During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat fever or pain. Recent insights from epidemiological studies suggest an association between prenatal acetaminophen medication and an increased risk for development of asthma in children later in life. The underlying pathogenesis of such association is still unknown. METHODS: We aimed to develop a mouse model to provide insights into the effect of prenatal acetaminophen on maternal, fetal and adult offspring's health...
May 2015: Journal of Hepatology
Tiffany Wong, Antonia S Stang, Heather Ganshorn, Lisa Hartling, Ian K Maconochie, Anna M Thomsen, David W Johnson
BACKGROUND: Health-care professionals frequently recommend fever treatment regimens for children who either combine paracetamol and ibuprofen or alternate them.However, there is uncertainty about whether these regimens are better than using single agents and about the adverse effect profile of combination regimens. OBJECTIVES: To assess the results and side effects of combining paracetamol and ibuprofen, or alternating them in consecutive treatments, compared with monotherapy for treating fever in children...
September 2014: Evidence-based Child Health: a Cochrane Review Journal
Tiffany Wong, Antonia S Stang, Heather Ganshorn, Lisa Hartling, Ian K Maconochie, Anna M Thomsen, David W Johnson
BACKGROUND: Health professionals frequently recommend fever treatment regimens for children that either combine paracetamol and ibuprofen or alternate them. However, there is uncertainty about whether these regimens are better than the use of single agents, and about the adverse effect profile of combination regimens. OBJECTIVES: To assess the effects and side effects of combining paracetamol and ibuprofen, or alternating them on consecutive treatments, compared with monotherapy for treating fever in children...
September 2014: Evidence-based Child Health: a Cochrane Review Journal
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