Ginevra Farnetani, Maria Grazia Fino, Francesca Cioppi, Antoni Riera-Escamilla, Lara Tamburrino, Matteo Vannucci, Viktoria Rosta, Serena Vinci, Elena Casamonti, Leila Turki, Selene Degl'Innocenti, Matilde Spinelli, Sara Marchiani, Francesco Lotti, Monica Muratori, Csilla Krausz
INTRODUCTION: Testicular germ cell tumor (TGCT) is the most frequent neoplasia in men of reproductive age, with a 5-year survival rate of 95%. Antineoplastic treatments induce sperm DNA fragmentation (SDF), especially within the first year post-therapy. Data in the literature are heterogeneous concerning longer follow-up periods and the large majority is limited to 2 years. OBJECTIVE: To define the timing for the recovery of sperm DNA damage and the proportion of patients with severe DNA damage (SDD) at 2 and 3 years from the end of therapy...
March 17, 2023: Andrology