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oral mucositis chemotherapy children

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https://www.readbyqxmd.com/read/29442455/oral-mucositis-and-saliva-iga-igg-and-igm-concentration-during-anti-tumor-treatment-in-children-suffering-from-acute-lymphoblastic-leukemia
#1
Elżbieta J Pels
BACKGROUND: Oral mucositis is a problem occurring within the oral cavity, which is the most difficult to deal with during anti-tumor treatment. The first symptom reported by the patient is discomfort. Salivary immunoglobulins play an important role in pathological processes occurring in the oral cavity. OBJECTIVES: The study objective was to assess the occurrence of oral mucositis and to assess changes in the saliva IgA, IgG, and IgM concentration in children with acute lymphoblastic leukemia during antitumor treatment...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29207005/global-health-journal-club-is-honey-effective-as-a-treatment-for-chemotherapy-induced-mucositis-in-paediatric-oncology-patients
#2
Amanda Friend, Fidel Rubagumya, Peter Cartledge
Oral mucositis (OM) is an inflammatory response of mucosal epithelium to the cytotoxic effects of chemotherapy and radiotherapy causing severe oral pain and ulceration, which may complicate the management of cancer. The Mucositis Prevention Guideline Development Group has developed an international guideline for the prevention of mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. Evidence-based preventative strategies include cryotherapy, low-level light therapy and keratinocyte growth factor...
November 30, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29182564/oral-mucositis-in-pediatric-patients-in-treatment-for-acute-lymphoblastic-leukemia
#3
Isabella Lima Arrais Ribeiro, Rebecca Rhuanny Tolentino Limeira, Ricardo Dias de Castro, Paulo Rogério Ferreti Bonan, Ana Maria Gondim Valença
Oral mucositis in oncologic patients is the most undesirable event of the chemotherapeutic treatment. This study aimed to identify damage to the oral cavity resulting from chemotherapy in pediatric patients with acute lymphoblastic leukemia (ALL). This is a prospective study with a sample of 42 children and adolescents evaluated for 10 consecutive weeks after diagnosis. The modified Oral Assessment Guide (OAG) was used, and data were analyzed by Spearman's rank correlation coefficient (α = 5%). Changes to the normal lips and saliva were positively related to an increase in the OAG score during all 10 weeks of evaluation...
November 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29181845/interventions-for-preventing-oral-mucositis-in-patients-with-cancer-receiving-treatment-cytokines-and-growth-factors
#4
REVIEW
Philip Riley, Anne-Marie Glenny, Helen V Worthington, Anne Littlewood, Luisa M Fernandez Mauleffinch, Jan E Clarkson, Martin G McCabe
BACKGROUND: Oral mucositis is a side effect of chemotherapy, head and neck radiotherapy, and targeted therapy, affecting over 75% of high-risk patients. Ulceration can lead to severe pain and difficulty with eating and drinking, which may necessitate opioid analgesics, hospitalisation and supplemental nutrition. These complications may disrupt cancer therapy, which may reduce survival. There is also a risk of death from sepsis if pathogens enter the ulcers of immunocompromised patients...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29175466/photodynamic-therapy-for-treatment-of-oral-mucositis-pilot-study-with-pediatric-patients-undergoing-chemotherapy
#5
Vânia Cavalcanti Ribeiro da Silva, Fabiana Moura da Motta Silveira, Gabriela Souza Lima, Mônica Moreira Dias da Cruz, Arnaldo de França Caldas Júnior, Gustavo Pina Godoy
BACKGROUND: Oral mucositis has become a major factor dose-limiting toxicity of antineoplastic treatment. AIM: The aim of the present study was to evaluate the effect of photodynamic therapy (PDT) and low level laser therapy (LLLT) on the treatment of chemotherapy-induced mucositis in pediatric patients. METHODS: An open, controlled, and blind, randomized clinical trial was conducted with 29 patients, from 10 months to 18 years old, who were divided into two groups...
November 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29128883/a-systematic-review-and-meta-analysis-of-the-effect-of-low-level-laser-therapy-lllt-on-chemotherapy-induced-oral-mucositis-in-pediatric-and-young-patients
#6
REVIEW
Mengxue He, Binghua Zhang, Nanping Shen, Na Wu, Jiwen Sun
Oral mucositis is one of the most frequent complications after chemotherapy, occurring in approximately 52 to 80% of children receiving treatment for cancer. Recently, it has been suggested that the use of low-energy laser could reduce the grade of oral mucositis and alleviate the symptoms. In 2014, Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology has recommended low-level laser therapy in prevention of mucositis for hematopoietic stem cell transplantation patients because of its beneficial effects in majority of recent studies...
November 11, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29045267/the-prevalence-and-investigation-of-risk-factors-of-oral-mucositis-in-a-pediatric-oncology-inpatient-population-a-prospective-study
#7
Gabrielle Allen, Richard Logan, Tom Revesz, Dorothy Keefe, Sam Gue
BACKGROUND: Oral mucositis can be a frequent and severe complication of chemotherapy in children. It can result in pain, infection, depression, prolonged admission, treatment delays, increase in patient morbidity, and increased costs. AIM: To record the prevalence and severity of oral mucositis among inpatients and explore the relationship of risks factors and the development of oral mucositis. DESIGN: During an 18-month period 643 clinical inpatient assessments were completed on 73 children who were admitted and had received chemotherapy in the last 14 days...
October 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28984677/advances-in-the-understanding-and-management-of-mucositis-during-stem-cell-transplantation
#8
Joanne M Bowen, Hannah R Wardill
PURPOSE OF REVIEW: Mucositis is a severe and common side effect of anticancer treatments, with an incidence of between 40 and 80% depending on the cytotoxic regimen used. The most profound mucositis burden is experienced during conditioning regimens for hematopoietic stem cell transplant (HSCT), where the use of highly mucotoxic agents with or without total body irradiation leads to serious damage throughout the alimentary tract. Currently, the assessment and management of both oral and gastrointestinal mucositis lack authoritative guideline, with recommendations only achieved in narrow clinical scenarios...
December 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28966962/measuring-oral-mucositis-of-pediatric-patients-with-cancer-a-psychometric-evaluation-of-chinese-version-of-the-oral-mucositis-daily-questionnaire
#9
Karis Kin Fong Cheng, Wan Yim Ip, Vincent Lee, Chak Ho Li, Hui Leung Yuen, Joel B Epstein
OBJECTIVE: Oral mucositis is a frequent clinical condition that has been shown to affect pediatric cancer patients. Oral Mucositis Daily Questionnaire (OMDQ) is one of the few available patient-reported outcome measures to assess the extent and impact of oral mucositis. The objectives of the study were to translate the Mouth and Throat Soreness-Related Questions of the OMDQ into Chinese (OMDQ MTS-Ch) for children and adolescents aged 6-18 years receiving chemotherapy and to evaluate its psychometric properties...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28890617/prevalence-of-oral-complications-occurring-in-a-population-of-pediatric-cancer-patients-receiving-chemotherapy
#10
Kapil Gandhi, Geetika Datta, Shilpa Ahuja, Tanvi Saxena, Ankush G Datta
Multiagent chemotherapy, radiotherapy, or a combination of both are the contemporary methods of cancer treatment. With medical advancements, though cure rates have increased considerably, focus is now shifted to the potential early and late complications of the same. The aim of this study was to assess the early oral complications in pediatric patients receiving chemotherapy. Sixty-two children with cancer undergoing chemotherapy with the mean age of 7.42 ± 3.6 years were included in the study. The various types of malignancies and oral problems during chemotherapy were recorded in the subjects...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28658926/role-of-vitamin-e-and-vitamin-a-in-oral-mucositis-induced-by-cancer-chemo-radiotherapy-a-meta-analysis
#11
REVIEW
Nallan Csk Chaitanya, Arvind Muthukrishnan, Dara Balaji Gandhi Babu, Chinta Sanjeeva Kumari, Madishetty Adi Lakshmi, Gayathri Palat, Khwaja Shoeb Alam
INTRODUCTION: Oral mucositis is known to hamper the quality of life in patients treated for oral cancer. Many pharmacological agents have been tried and tested in its management, especially vitamin supplements including A, E and their combinations. AIM: A Meta-analysis was carried out to evaluate the efficacy of vitamins individually used for prevention or treatment of oral mucositis separately for chemotherapy, concurrent chemo radiotherapy, radiotherapy and Haematopoietic Stem Cell Transplantation (HSCT) individuals...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28349509/a-new-emerging-oral-infection-raoultella-planticola-in-a-boy-with-haematological-malignancy
#12
E Bardellini, F Amadori, R F Schumacher, I Foresti, A Majorana
BACKGROUND: Oral mucositis is a common complication in pediatric cancer patients, affecting up to 80% of children. Due to neutropenia and disruption of the mucosal barrier, chemotherapy-induced oral mucositis is often complicated by super-infections. CASE REPORT: A 16-years old male with stage 3 Burkitt's lymphoma developed chemotherapy induced oral mucositis grade 3 (according to WHO scale). Ulcers were quickly growing (reaching a maximum diameter of 3 cm) and became greyish in colour, resulting in dysphagia and pain...
June 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28333866/prevention-of-gastrointestinal-side-effects-in-paediatric-oncology-what-are-the-guidelines
#13
Karis K F Cheng
PURPOSE OF REVIEW: Gastrointestinal side-effects, particularly with regard to alimentary tract mucositis and chemotherapy-induced nausea and vomiting (CINV), continue to be frequent and debilitating symptomatic conditions among children and adolescents receiving cytotoxic cancer therapy. Further avenues of progress for mucositis and CINV prevention in paediatric oncology setting are warranted. RECENT FINDINGS: The current article reviews the major guidelines and literature published in 2016 pertaining to the prevention of mucositis and CINV...
June 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28109192/prevalence-of-oral-manifestations-in-children-and-adolescents-with-cancer-submitted-to-chemotherapy
#14
Deise Berger Velten, Eliana Zandonade, Maria Helena Monteiro de Barros Miotto
BACKGROUND: Oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG). METHODS: The study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy...
January 20, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/27942550/palifermin-and-chlorhexidine-mouthwashes-in-prevention-of-chemotherapy-induced-mucositis-in-children-with-acute-lymphocytic-leukemia-a-randomized-controlled-trial
#15
Narges Gholizadeh, Masoumeh Mehdipoor, Hasan Sajadi, Mahdieh-Sadat Moosavi
STATEMENT OF THE PROBLEM: Over the past three decades, significant improvements have been achieved in the survival of children with cancer. However, the considerable morbidity which occurs as a result of chemotherapy often restricts the treatment intensity. One of the important dose-limiting and costly adverse effects of cancer therapy is mucositis. Children with hematological malignancies are greatly at risk of developing mucositis. PURPOSE: This study aimed to assess the effectiveness of palifermin in preventing mucositis in children with acute lymphocytic leukemia (ALL) who undergo chemotherapy...
December 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27927117/pain-management-for-chemotherapy-induced-oral-mucositis
#16
Michelle Bennett
The number of children and young people diagnosed with cancer is increasing every year. Pain is a significant side effect of disease, surgery and treatments including chemotherapy. After a course of intensive chemotherapy, some children develop oral mucositis, a debilitating condition causing bleeding, pain and inflammation. Moderate and severe mucositis pain is treated with continued good oral hygiene and parenteral analgesia. The aim of this article is to identify challenges in managing chemotherapy-induced oral mucositis pain in children, and to highlight the benefits of adding ketamine as an adjuvant analgesic...
December 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27912937/honey-prevents-oral-mocositis-in-children-undergoing-chemotherapy-a-quasi-experimental-study-with-a-control-group
#17
Hacer Kobya Bulut, Fatma Güdücü Tüfekci
BACKGROUND: There are numerous pharmacological and non-pharmacological treatment options available in the treatment of oral mucositis. However, in spite of so many methods and products, medical professionals have not come to a consensus as to which of these offer the best results. OBJECTIVES: This study was conducted to assess the effect of oral care with honey on children undergoing chemotherapy for the prevention and healing of oral mucositis. METHODS: This quasi-experimental study was conducted on children undergoing chemotherapy...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27716167/prevalence-of-oral-manifestations-in-children-and-adolescents-with-cancer-submitted-to-chemotherapy
#18
Deise Berger Velten, Eliana Zandonade, Maria Helena Monteiro de Barros Miotto
BACKGROUND: Oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG). METHODS: The study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy...
October 3, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27616655/risk-factors-for-bacteremia-and-central-line-associated-blood-stream-infections-in-children-with-acute-myelogenous-leukemia-a-single-institution-report
#19
COMPARATIVE STUDY
Ashley E J Rogers, Kristen M Eisenman, Susan A Dolan, Kristin M Belderson, Jocelyn R Zauche, Suhong Tong, Jane Gralla, Joanne M Hilden, Michael Wang, Kelly W Maloney, Samuel R Dominguez
BACKGROUND: Central line-associated blood stream infections (CLABSIs) are a source of high morbidity and mortality in children with acute myelogenous leukemia (AML). PROCEDURE: To understand the epidemiology and risk factors associated with the development of CLABSI in children with AML. METHODS: We retrospectively reviewed all patients with AML over a 5-year period between 2007 and 2011 at the Children's Hospital Colorado. Cases and controls were classified on the basis of the presence of a CLABSI as defined by the National Healthcare Safety Network...
March 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27571124/efficacy-of-a-solution-composed-by-verbascoside-polyvinylpyrrolidone-pvp-and-sodium-hyaluronate-in-the-treatment-of-chemotherapy-induced-oral-mucositis-in-children-with-acute-lymphoblastic-leukemia
#20
RANDOMIZED CONTROLLED TRIAL
Elena Bardellini, Francesca Amadori, Richard Fabian Schumacher, Carmelita D'Ippolito, Fulvio Porta, Alessandra Majorana
The aim of this study was to assess the efficacy of a solution composed by verbascoside, polyvinylpyrrolidone, and sodium hyaluronate (Mucosyte) in the treatment of chemotherapy-induced oral mucositi (OM). Patients between 5 and 18 years receiving chemotherapy for acute lymphoblastic leukemia and with OM grade 1 or 2 were randomized in group A (treated with Mucosyte, 3 mouthwashes/d per 8 d) and group B (treated with placebo, ie, an inert water-based solution, 3 mouthwashes/d per 8 d). The OM scoring was performed at day 1 (diagnosis of OM-T0), after 3 days of treatment (T1), and at day 8 (T2)...
October 2016: Journal of Pediatric Hematology/oncology
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