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oral mucositis chemotherapy children

Nallan Csk Chaitanya, Arvind Muthukrishnan, Dara Balaji Gandhi Babu, Chinta Sanjeeva Kumari, Madishetty Adi Lakshmi, Gayathri Palat, Khwaja Shoeb Alam
INTRODUCTION: Oral mucositis is known to hamper the quality of life in patients treated for oral cancer. Many pharmacological agents have been tried and tested in its management, especially vitamin supplements including A, E and their combinations. AIM: A Meta-analysis was carried out to evaluate the efficacy of vitamins individually used for prevention or treatment of oral mucositis separately for chemotherapy, concurrent chemo radiotherapy, radiotherapy and Haematopoietic Stem Cell Transplantation (HSCT) individuals...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
E Bardellini, F Amadori, R F Schumacher, I Foresti, A Majorana
BACKGROUND: Oral mucositis is a common complication in pediatric cancer patients, affecting up to 80% of children. Due to neutropenia and disruption of the mucosal barrier, chemotherapy-induced oral mucositis is often complicated by super-infections. CASE REPORT: A 16-years old male with stage 3 Burkitt's lymphoma developed chemotherapy induced oral mucositis grade 3 (according to WHO scale). Ulcers were quickly growing (reaching a maximum diameter of 3 cm) and became greyish in colour, resulting in dysphagia and pain...
March 27, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Karis K F Cheng
PURPOSE OF REVIEW: Gastrointestinal side-effects, particularly with regard to alimentary tract mucositis and chemotherapy-induced nausea and vomiting (CINV), continue to be frequent and debilitating symptomatic conditions among children and adolescents receiving cytotoxic cancer therapy. Further avenues of progress for mucositis and CINV prevention in paediatric oncology setting are warranted. RECENT FINDINGS: The current article reviews the major guidelines and literature published in 2016 pertaining to the prevention of mucositis and CINV...
June 2017: Current Opinion in Supportive and Palliative Care
Deise Berger Velten, Eliana Zandonade, Maria Helena Monteiro de Barros Miotto
BACKGROUND: Oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG). METHODS: The study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy...
January 20, 2017: BMC Oral Health
Narges Gholizadeh, Masoumeh Mehdipoor, Hasan Sajadi, Mahdieh-Sadat Moosavi
STATEMENT OF THE PROBLEM: Over the past three decades, significant improvements have been achieved in the survival of children with cancer. However, the considerable morbidity which occurs as a result of chemotherapy often restricts the treatment intensity. One of the important dose-limiting and costly adverse effects of cancer therapy is mucositis. Children with hematological malignancies are greatly at risk of developing mucositis. PURPOSE: This study aimed to assess the effectiveness of palifermin in preventing mucositis in children with acute lymphocytic leukemia (ALL) who undergo chemotherapy...
December 2016: Journal of Dentistry
Michelle Bennett
The number of children and young people diagnosed with cancer is increasing every year. Pain is a significant side effect of disease, surgery and treatments including chemotherapy. After a course of intensive chemotherapy, some children develop oral mucositis, a debilitating condition causing bleeding, pain and inflammation. Moderate and severe mucositis pain is treated with continued good oral hygiene and parenteral analgesia. The aim of this article is to identify challenges in managing chemotherapy-induced oral mucositis pain in children, and to highlight the benefits of adding ketamine as an adjuvant analgesic...
December 8, 2016: Nursing Children and Young People
Hacer Kobya Bulut, Fatma Güdücü Tüfekci
BACKGROUND: There are numerous pharmacological and non-pharmacological treatment options available in the treatment of oral mucositis. However, in spite of so many methods and products, medical professionals have not come to a consensus as to which of these offer the best results. OBJECTIVES: This study was conducted to assess the effect of oral care with honey on children undergoing chemotherapy for the prevention and healing of oral mucositis. METHODS: This quasi-experimental study was conducted on children undergoing chemotherapy...
December 2016: Complementary Therapies in Medicine
Deise Berger Velten, Eliana Zandonade, Maria Helena Monteiro de Barros Miotto
BACKGROUND: Oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG). METHODS: The study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy...
October 3, 2016: BMC Oral Health
Ashley E J Rogers, Kristen M Eisenman, Susan A Dolan, Kristin M Belderson, Jocelyn R Zauche, Suhong Tong, Jane Gralla, Joanne M Hilden, Michael Wang, Kelly W Maloney, Samuel R Dominguez
BACKGROUND: Central line-associated blood stream infections (CLABSIs) are a source of high morbidity and mortality in children with acute myelogenous leukemia (AML). PROCEDURE: To understand the epidemiology and risk factors associated with the development of CLABSI in children with AML. METHODS: We retrospectively reviewed all patients with AML over a 5-year period between 2007 and 2011 at the Children's Hospital Colorado. Cases and controls were classified on the basis of the presence of a CLABSI as defined by the National Healthcare Safety Network...
March 2017: Pediatric Blood & Cancer
Elena Bardellini, Francesca Amadori, Richard Fabian Schumacher, Carmelita D'Ippolito, Fulvio Porta, Alessandra Majorana
The aim of this study was to assess the efficacy of a solution composed by verbascoside, polyvinylpyrrolidone, and sodium hyaluronate (Mucosyte) in the treatment of chemotherapy-induced oral mucositi (OM). Patients between 5 and 18 years receiving chemotherapy for acute lymphoblastic leukemia and with OM grade 1 or 2 were randomized in group A (treated with Mucosyte, 3 mouthwashes/d per 8 d) and group B (treated with placebo, ie, an inert water-based solution, 3 mouthwashes/d per 8 d). The OM scoring was performed at day 1 (diagnosis of OM-T0), after 3 days of treatment (T1), and at day 8 (T2)...
October 2016: Journal of Pediatric Hematology/oncology
Francesca Amadori, Elena Bardellini, Giulio Conti, Nicola Pedrini, Richard Fabian Schumacher, Alessandra Majorana
The aim of this study was to verify if low-level laser therapy could be useful to reduce chemotherapy-related oral mucositis grading and pain in childhood undergoing chemotherapy. A randomized double-blind clinical trial was carried out. Patients from 3 to 18 years of age undergoing cancer therapy and presenting OM grade 2 or more were eligible for this study. Patients were randomly divided in two groups: group A received laser therapy from the day of OM diagnosis and other 3 consecutive days (830 nm wavelength, power 150 mW, spot size 1 cm(2), 30 s per cm(2), energy density 4...
August 2016: Lasers in Medical Science
A Eghbali, B Taherkhanchi, B Bagheri, B Sadeghi Sedeh
BACKGROUND: Oral mucositis is an adverse effect of chemotherapy. Type of chemotherapy regimen is the most important factor causing mucositis. Oral mucositis is usually associated with transient decrease in saliva production. The goal was to study effects of gum consumption on oral mucositis in children undergoing chemotherapy. MATERIALS AND METHOD: This randomized controlled trial was done in Amir Kabir Hospital, Arak, Iran. 130 children 5 to 15 years of age were studied...
2016: Iranian Journal of Pediatric Hematology and Oncology
E Bardellini, F Amadori, A Majorana
AIM: The aim of this study was to assess the impact of the use of a fluoride toothpaste (Bioxtra(®) , Biopharm, Milan, Italy) with salivary enzymes, essential oils, proteins and colostrum extract versus a fluoride toothpaste without menthol on the oral hygiene grade and on the quality of life (QoL) of children with oral mucositis (OM) grade 1 or 2 receiving chemotherapy for Acute Lymphoblastic Leukaemia (ALL). METHODS: Patients between 6 and 14 years with OM were randomly assigned to two groups, group A (Bioxtra(®) toothpaste) and group B (fluoride toothpaste without menthol)...
November 2016: International Journal of Dental Hygiene
Ewa Krasuska-Sławińska, Agnieszka Brożyna, Bożenna Dembowska-Bagińska, Dorota Olczak-Kowalczyk
AIM OF THE STUDY: To determine reasons for the increase in caries among children/adolescents treated for neoplasms. MATERIAL AND METHODS: Health promoting behaviour, oral hygiene (PLI), gingiva (GI), dentition (DMFt/DMFs), number of teeth with white spot lesions (WSL), and enamel defects (ED) were assessed in three groups of 60 patients each. The three groups were as follows: under chemotherapy (CH), after chemotherapy (PCH), and generally healthy (CG). Medical files supplied information on neoplasm type, chemotherapeutic type and dose, age at treatment start, chemotherapy duration, and complications...
2016: Contemporary Oncology Współczesna Onkologia
A El Bousaadani, L Eljahd, R Abada, S Rouadi, M Roubal, M Mahtar
Oral mucositis is an inflammation of the mucosa of the oral cavity of various etiologies. This is a common and debilitating complication in children treated with chemoradiotherapy for cancer. Its management remains a major concern both for the doctor than the patient. It affects the quality of life of patients and families. It may initiate the functional and vital prognosis because of the judgment of cancer treatment. Several treatment options are available, but there is no clear consensus therapeutic especially for the pediatric population...
May 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Caroline Pixberg, Raphael Koch, Hans Theodor Eich, Ulla Martinsson, Ingrid Kristensen, Christiane Matuschek, Rolf-Dieter Kortmann, Fabian Pohl, Khaled Elsayad, Hans Christiansen, Normann Willich, Jack Lindh, Diana Steinmann
PURPOSE: In the context of oncologic therapy for children, radiation therapy is frequently indicated. This study identified the frequency of and reasons for the development of high-grade acute toxicity and possible sequelae. MATERIALS AND METHODS: Irradiated children have been prospectively documented since 2001 in the Registry for the Evaluation of Side Effects After Radiation in Childhood and Adolescence (RiSK) database in Germany and since 2008 in the registry for radiation therapy toxicity (RADTOX) in Sweden...
March 15, 2016: International Journal of Radiation Oncology, Biology, Physics
Marcos Soto, Rajesh V Lalla, Roseane Vasconcelos Gouveia, Victor Gattardello Zecchin, Adriana Seber, Nilza Nelly Fontana Lopes
OBJECTIVE AND BACKGROUND DATA: Studies suggest that intraoral low-level laser therapy (LLLT) can ameliorate oral mucositis in adult patients receiving high-dose chemotherapy. The objective of this study was to evaluate the use of a combined protocol of intraoral and extraoral LLLT in children undergoing hematopoietic stem cell transplantation (HSCT). METHODS: Twelve children undergoing HSCT were treated four times a week with a combined protocol of intraoral and extraoral LLLT, for a mean duration of 22 days...
November 2015: Photomedicine and Laser Surgery
A Hashemi, Z Bahrololoumi, Y Khaksar, N Saffarzadeh, H Neamatzade, E Foroughi
BACKGROUND: The purpose of this review was to evaluate studies in basic oral care interventions to update evidence based practice guidelines for preventing oral mucositis (OM) in cancer patients undergoing chemotherapy. MATERIAL & METHODS: Pub Med database and Google Scholar were searched for all papers published between 2000 and December 2014 in English that were conducted using the search terms including ''mocusitis, chemotherapy, mouth-rinses, oral care, oral care protocol, dental care,dental cleaning, oral decontamination, oral hygiene", and the combined phrases in order to obtain all relevant studies...
2015: Iranian Journal of Pediatric Hematology and Oncology
Regina Maria Holanda de Mendonça, Marcela de Araújo, Carlos Emilio Levy, Joseane Morari, Rosângela A Silva, José Andres Yunes, Silvia Regina Brandalise
OBJECTIVE: to investigate the associations of oral microbiota, leucocytes count, neutrophil count, platelet counts and hemoglobin level, and the severity of oral mucositis in pediatric patients with acute lymphoblastic leukemia (ALL) receiving chemotherapy. MATERIALS AND METHODS: 71 prospective patients were included. Analyses of oral microbiota and blood sample were conducted on days 14 (D14) and 56 (D56) of the Brazilian GBTLI-99 treatment protocol. Herpes simplex virus (HSV) identification was performed by PCR followed by DNA sequencing analysis...
2015: Pediatric Hematology and Oncology
Elham Olad, Iraj Sedighi, Azim Mehrvar, Maryam Tashvighi, Vahid Fallahazad, Amirabbas Hedayatiasl, Hossein Esfahani
OBJECTIVE: Timely detection of serious bacterial infections or prediction of sepsis and death is of paramount importance in neutropenic patients especially in oncology settings. The aim of this study was to determine a rapid and secure predictor of sepsis in severe neutropenic cancer children. METHODS: In addition to blood culture, we have evaluated serum soluble CD14 on this role and measured it in 39 neutropenic episodes in Mahak pediatric oncology center from September 2012 to January 2013...
December 2014: Iranian Journal of Pediatrics
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