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modified citrus pectine

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https://www.readbyqxmd.com/read/28900464/synergistic-antioxidant-and-anti-inflammatory-effects-between-modified-citrus-pectin-and-honokiol
#1
Cheppail Ramachandran, Barry Wilk, Steven J Melnick, Isaac Eliaz
Inflammation is a normal physiological process; however, dysregulation of this process may contribute to inflammatory-based chronic disorders and diseases in animals and humans. Therefore, the antioxidant and anti-inflammatory properties of natural products, often recognized in traditional medicine systems, represent therapeutic modalities to reduce or prevent uncontrolled inflammatory processes which in turn potentially ameliorate or prevent sequelae of inflammatory-based symptoms of chronic diseases. We have investigated the antioxidant and anti-inflammatory effects of honokiol (HNK) and modified citrus pectin (MCP) in vitro and examined whether the MCP : HNK combination has synergistic effects on antioxidant and anti-inflammatory properties...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28858976/galectin-3-pharmacological-inhibition-attenuates-early-renal-damage-in-spontaneously-hypertensive-rats
#2
Ernesto Martínez-Martínez, Jaime Ibarrola, Amaya Fernández-Celis, Laurent Calvier, Celine Leroy, Victoria Cachofeiro, Patrick Rossignol, Natalia López-Andrés
BACKGROUND: The pharmacological blockade of galectin-3 (Gal-3), a β-galactoside-binding lectin, reduces renal impairment in acute kidney injury, hyperaldosteronism or nephropathy. We herein investigated the effects of pharmacological Gal-3 inhibition by modified citrus pectin (MCP) in renal damage in spontaneously hypertensive rats (SHRs). METHODS AND RESULTS: Gal-3 inhibition did not modify blood pressure levels in 30-week-old SHR. Kidney weight was higher in SHR, with no effect of MCP treatment (100 mg/kg/day in the drinking water)...
August 30, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28843267/screening-for-circulating-tumour-cells-allows-early-detection-of-cancer-and-monitoring-of-treatment-effectiveness-an-observational-study
#3
Karin Ried, Peter Eng, Avni Sali
Background: Circulating-Tumour-Cells (CTC) provide a blood biomarker for early carcinogenesis, cancer progression and treatment effectiveness. An increase in CTCs is associated with cancer progression, a CTC decrease with cancer containment or remission. Several technologies have been developed to identify CTC, including the validated Isolation-by-Size-of-Epithelial-Tumour (ISET, Rarecells) technology, combining blood filtration and microscopy using standard histo-pathological criteria. Methods: This observational study compared CTC count to cancer status and cancer risk, by monitoring treatment effectiveness in cancer patients and by screening for CTC in asymptomatic patients with risk factors, including family history of cancer...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28818729/characterization-of-citrus-pectin-films-integrated-with-clove-bud-essential-oil-physical-thermal-barrier-antioxidant-and-antibacterial-properties
#4
Tanzeela Nisar, Zi-Chao Wang, Xi Yang, You Tian, Muneeb Iqbal, Yurong Guo
The increasing demand for bio-based materials to be used in food packaging has stimulated the development of novel, environmentally-friendly edible films. Antimicrobial films were developed by incorporating different levels of clove bud essential oil (0.5%, 1.0%, and 1.5%) into the citrus pectin in order to modify the functional properties of the films. Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry analysis (DSC) and X-ray diffraction (XRD) were performed, together with the determination of physical, optical, mechanical, antioxidant and antimicrobial properties of pectin emulsified films...
August 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28758988/beneficial-effects-of-galectin-3-blockade-in-vascular-and-aortic-valve-alterations-in-an-experimental-pressure-overload-model
#5
Jaime Ibarrola, Ernesto Martínez-Martínez, J Rafael Sádaba, Vanessa Arrieta, Amaia García-Peña, Virginia Álvarez, Amaya Fernández-Celis, Alicia Gainza, Patrick Rossignol, Victoria Cachofeiro Ramos, Natalia López-Andrés
Galectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification. We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) could reduce aortic and AV remodeling in normotensive rats with pressure overload (PO). Six weeks after aortic constriction, vascular Gal-3 expression was up-regulated in male Wistar rats. Gal-3 overexpression was accompanied by an increase in the aortic media layer thickness, enhanced total collagen, and augmented expression of fibrotic mediators...
July 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28648174/functionalization-of-pectin-with-laccase-mediated-oxidation-products-of-ferulic-acid
#6
N Karaki, A Aljawish, L Muniglia, S Bouguet-Bonnet, S Leclerc, C Paris, J Jasniewski, C Humeau-Virot
Pectin is a natural biopolymer extracted mostly from citrus peel, sugar beet and apple pomace. In order to improve its functional properties and then to enlarge the field of its potential applications, functionalization reaction of citrus pectin with ferulic acid (FA)-oxidation products was performed in aqueous medium, at 30°C and pH7.5, in the presence of Myceliophthora thermophila laccase as biocatalyst. The conjugation between FA-oxidation products and pectin was confirmed using FTIR, UV-Vis and LC-MS analyses...
September 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28560429/modified-citrus-pectin-inhibits-galectin-3-function-to-reduce-atherosclerotic-lesions-in-apoe-deficient-mice
#7
Yonggang Lu, Mingming Zhang, Pei Zhao, Min Jia, Bing Liu, Qian Jia, Jun Guo, Lin Dou, Jian Li
Galectin-3 is a carbohydrate-binding lectin, which has been implicated in the modulation of atherosclerotic pathophysiology, and is highly expressed in monocytes, macrophages and endothelial cells within atherosclerotic plaques. Modified citrus pectin (MCP) is produced from citrus pectin via pH and temperature modifications, which break it into shorter, non‑branched, galactose‑rich carbohydrate chains. MCP is able to tightly bind with galectin‑3, via recognition of its carbohydrate recognition domain, and facilitates the modulation of galectin‑3‑induced bioactivity...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28274429/pectic-oligosaccharide-structure-function-relationships-prebiotics-inhibitors-of-escherichia-coli-o157-h7-adhesion-and-reduction-of-shiga-toxin-cytotoxicity-in-ht29-cells
#8
Rong Di, Malathi S Vakkalanka, Chatchaya Onumpai, Hoa K Chau, Andre White, Robert A Rastall, Kit Yam, Arland T Hotchkiss
Shiga toxin (Stx)-producing, food-contaminating Escherichia coli (STEC) is a major health concern. Plant-derived pectin and pectic-oligosaccharides (POS) have been considered as prebiotics and for the protection of humans from Stx. Of five structurally different citrus pectic samples, POS1, POS2 and modified citrus pectin 1 (MCP1) were bifidogenic with similar fermentabilities in human faecal cultures and arabinose-rich POS2 had the greatest prebiotic potential. Pectic oligosaccharides also enhanced lactobacilli growth during mixed batch faecal fermentation...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28266280/additive-effect-of-mcp-in-combination-with-cefotaxime-against-staphylococcus-aureus
#9
Roula M Abdel-Massih, Elias Baydoun, Salah El-Khatib, Elias Dahdouh
BACKGROUND: Pectin is a heterogeneous polysaccharide present in plants and citrus fruits. It exhibits different beneficial biological activities. Conflicting reports exist about the antimicrobial effect of pectin and its derivatives. OBJECTIVE: In this study, we investigate the antimicrobial effect of Modified Citrus Pectin (MCP) against Staphylococcus aureus, a pathogen showing increasing rates of antimicrobial resistance worldwide. METHODS: Forty-three clinical isolates of S...
March 6, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/27993542/modification-of-citrus-and-apple-pectin-by-power-ultrasound-effects-of-acid-and-enzymatic-treatment
#10
Nerea Muñoz-Almagro, Antonia Montilla, F Javier Moreno, Mar Villamiel
Pectin-derived oligosaccharides are emerging as a new generation of functional ingredients with new or improved technological and/or bioactive properties as compared to pectin. This work addresses the impact of power ultrasound (US) on the structure of citrus and apple pectin under different experimental conditions of power, amplitude and pectin concentration in aqueous and acid media, as well as in the presence of a pectinase. Results indicated that depolymerisation of both pectin increased with time and intensity of US in aqueous media and their polydispersity decreased...
December 1, 2016: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27842844/rheological-and-chemical-properties-of-pectin-enriched-fractions-from-different-sources-extracted-with-citric-acid
#11
Joanna Mierczyńska, Justyna Cybulska, Artur Zdunek
Yield, properties and functionality of pectins depend on the source material and method of extraction. The objective of this work was to compare pectinolytic enzyme activity in fresh pulp as well as the physicochemical and rheological properties of polysaccharides extracted with citric acid from six new potential sources: fruit materials - peach, blackcurrant, raspberry, strawberry, plum and a vegetable Source: carrot. The uronic acid content of polysaccharides extracted in citric acid depended on pectinolytic enzymes activity in fresh plant tissues and ranged between 16...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27829066/galectin-3-blockade-reduces-renal-fibrosis-in-two-normotensive-experimental-models-of-renal-damage
#12
Ernesto Martinez-Martinez, Jaime Ibarrola, Laurent Calvier, Amaya Fernandez-Celis, Celine Leroy, Victoria Cachofeiro, Patrick Rossignol, Natalia Lopez-Andres
BACKGROUND: Galectin-3 (Gal-3), a β-galactoside-binding lectin, is increased in kidney injury and its pharmacological blockade reduces renal damage in acute kidney injury, hyperaldosteronism or hypertensive nephropathy. We herein investigated the effects of pharmacological Gal-3 inhibition by modified citrus pectin (MCP) in early renal damage associated with obesity and aortic stenosis (AS). RESULTS: Gal-3 was upregulated in kidneys from high fat diet (HFD) rats and in animals with partial occlusion of ascending aorta (AS)...
2016: PloS One
https://www.readbyqxmd.com/read/27815266/role-for-galectin-3-in-calcific-aortic-valve-stenosis
#13
J Rafael Sádaba, Ernesto Martínez-Martínez, Vanessa Arrieta, Virginia Álvarez, Amaya Fernández-Celis, Jaime Ibarrola, Amaia Melero, Patrick Rossignol, Victoria Cachofeiro, Natalia López-Andrés
BACKGROUND: Aortic stenosis (AS) is a chronic inflammatory disease, and calcification plays an important role in the progression of the disease. Galectin-3 (Gal-3) is a proinflammatory molecule involved in vascular osteogenesis in atherosclerosis. Therefore, we hypothesized that Gal-3 could mediate valve calcification in AS. METHODS AND RESULTS: Blood samples and aortic valves (AVs) from 77 patients undergoing AV replacement were analyzed. As controls, noncalcified human AVs were obtained at autopsy (n=11)...
November 4, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27129206/low-or-no-inhibitory-potency-of-the-canonical-galectin-carbohydrate-binding-site-by-pectins-and-galactomannans
#14
John Stegmayr, Adriana Lepur, Barbro Kahl-Knutson, Matilde Aguilar-Moncayo, Anatole A Klyosov, Robert A Field, Stina Oredsson, Ulf J Nilsson, Hakon Leffler
Some complex plant-derived polysaccharides, such as modified citrus pectins and galactomannans, have been shown to have promising anti-inflammatory and anti-cancer effects. Most reports propose or claim that these effects are due to interaction of the polysaccharides with galectins because the polysaccharides contain galactose-containing side chains that might bind this class of lectin. However, their direct binding to and/or inhibition of the evolutionarily conserved galactoside-binding site of galectins has not been demonstrated...
June 17, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27010252/modified-citrus-pectin-stops-progression-of-liver-fibrosis-by-inhibiting-galectin-3-and-inducing-apoptosis-of-stellate-cells
#15
COMPARATIVE STUDY
Nashwa M Abu-Elsaad, Wagdi Fawzi Elkashef
Modified citrus pectin (MCP) is a pH modified form of the dietary soluble citrus peel fiber known as pectin. The current study aims at testing its effect on liver fibrosis progression. Rats were injected with CCl4 (1 mL/kg, 40% v/v, i.p., twice a week for 8 weeks). Concurrently, MCP (400 or 1200 mg/kg) was administered daily in drinking water from the first week in groups I and II (prophylactic model) and in the beginning of week 5 in groups III and IV (therapeutic model). Liver function biomarkers (ATL, AST, and ALP), fibrosis markers (laminin and hyaluronic acid), and antioxidant biomarkers (reduced glutathione (GSH) and superoxide dismutase (SOD)) were measured...
May 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/26872020/galectin-3-inhibition-is-associated-with-neuropathic-pain-attenuation-after-peripheral-nerve-injury
#16
Zhicong Ma, Qi Han, Xiaolei Wang, Zisheng Ai, Yongjun Zheng
Neuropathic pain remains a prevalent and persistent clinical problem because it is often poorly responsive to the currently used analgesics. It is very urgent to develop novel drugs to alleviate neuropathic pain. Galectin-3 (gal3) is a multifunctional protein belonging to the carbohydrate-ligand lectin family, which is expressed by different cells. Emerging studies showed that gal3 elicits a pro-inflammatory response by recruiting and activating lymphocytes, macrophages and microglia. In the study we investigated whether gal3 inhibition could suppress neuroinflammation and alleviate neuropathic pain following peripheral nerve injury...
2016: PloS One
https://www.readbyqxmd.com/read/26853916/galectin-3-inhibition-prevents-adipose-tissue-remodelling-in-obesity
#17
E Martínez-Martínez, L Calvier, P Rossignol, E Rousseau, A Fernández-Celis, R Jurado-López, M Laville, V Cachofeiro, N López-Andrés
Extracellular matrix remodelling of the adipose tissue has a pivotal role in the pathophysiology of obesity. Galectin-3 (Gal-3) is increased in obesity and mediates inflammation and fibrosis in the cardiovascular system. However, the effects of Gal-3 on adipose tissue remodelling associated with obesity remain unclear. Male Wistar rats were fed either a high-fat diet (33.5% fat) or a standard diet (3.5% fat) for 6 weeks. Half of the animals of each group were treated with the pharmacological inhibitor of Gal-3, modified citrus pectin (MCP; 100 mg kg(-1) per day) in the drinking water...
June 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26781273/inhibition-of-galectin-3-pathway-prevents-isoproterenol-induced-left-ventricular-dysfunction-and-fibrosis-in-mice
#18
Giuseppe Vergaro, Mathilde Prud'homme, Loubina Fazal, Regine Merval, Claudio Passino, Michele Emdin, Jane-Lise Samuel, Alain Cohen Solal, Claude Delcayre
Galectin-3 (Gal-3) is involved in inflammation, fibrogenesis, and cardiac remodeling. Previous evidence shows that Gal-3 interacts with aldosterone in promoting macrophage infiltration and vascular fibrosis and that Gal-3 genetic and pharmacological inhibition prevents remodeling in a pressure-overload animal model of heart failure. We aimed to explore the contribution of Gal-3 and aldosterone in mechanisms leading to heart failure in a murine model. Male mice with cardiac-specific hyperaldosteronism underwent isoproterenol subcutaneous injections, to be then randomized to receive placebo, a Gal-3 inhibitor (modified citrus pectin [MCP]), an aldosterone antagonist (potassium canrenoate), or MCP+canrenoate for 14 days...
March 2016: Hypertension
https://www.readbyqxmd.com/read/26686103/identification-of-a-cytotoxic-molecule-in-heat-modified-citrus-pectin
#19
Lionel Leclere, Maude Fransolet, Pierre Cambier, Sandy El Bkassiny, Abdellatif Tikad, Marc Dieu, Stéphane P Vincent, Pierre Van Cutsem, Carine Michiels
Modified forms of citrus pectin possess anticancer properties. However, their mechanism of action and the structural features involved remain unclear. Here, we showed that citrus pectin modified by heat treatment displayed cytotoxic effects in cancer cells. A fractionation approach was used aiming to identify active molecules. Dialysis and ethanol precipitation followed by HPLC analysis evidenced that most of the activity was related to molecules with molecular weight corresponding to low degree of polymerization oligogalacturonic acid...
February 10, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/26572430/modified-sugar-beet-pectin-induces-apoptosis-of-colon-cancer-cells-via-an-interaction-with-the-neutral-sugar-side-chains
#20
Ellen G Maxwell, Ian J Colquhoun, Hoa K Chau, Arland T Hotchkiss, Keith W Waldron, Victor J Morris, Nigel J Belshaw
Pectins extracted from a variety of sources and modified with heat and/or pH have previously been shown to exhibit activity towards several cancer cell lines. However, the structural basis for the anti-cancer activity of modified pectin requires clarification. Sugar beet and citrus pectin extracts have been compared. Pectin extracted from sugar beet pulp only weakly affected the viability of colon cancer cells. Alkali treatment increased the anti-cancer effect of sugar beet pectin via an induction of apoptosis...
January 20, 2016: Carbohydrate Polymers
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