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https://www.readbyqxmd.com/read/27932310/loss-of-dopamine-d1-receptors-and-diminished-d1-5-receptor-mediated-erk-phosphorylation-in-the-periaqueductal-gray-after-spinal-cord-lesion
#1
Pamela J Voulalas, Yadong Ji, Li Jiang, Jamila Asgar, Jin Y Ro, Radi Masri
Neuropathic pain resulting from spinal cord injury is often accompanied by maladaptive plasticity of the central nervous system, including the opioid receptor-rich periaqueductal gray (PAG). Evidence suggests that sensory signaling via the PAG is robustly modulated by dopamine D1- and D2-like receptors, but the effect of damage to the spinal cord on D1 and D2 receptor protein expression and function in the PAG has not been examined. Here we show that 21 days after a T10 or C6 spinothalamic tract lesion, both mice and rats display a remarkable decline in the expression of D1 receptors in the PAG, revealed by western blot analysis...
December 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27932062/experiencing-neonatal-maternal-separation-increased-pain-sensitivity-in-adult-male-mice-involvement-of-oxytocinergic-system
#2
Hossein Amini-Khoei, Shayan Amiri, Ali Mohammadi-Asl, Sakineh Alijanpour, Simin Poursaman, Arya Haj-Mirzaian, Mojgan Rastegar, Azam Mesdaghinia, Hamid Reza Banafshe, Ehsanollah Sadeghi, Elika Samiei, Shahram Ejtemaie Mehr, Ahmad Reza Dehpour
Early-life stress adversely affects the development of the brain, and alters a variety of behaviors such as pain in later life. In present study, we investigated how early-life stress (maternal separation or MS) can affect the nociceptive response later in life. We particularly focused on the role of oxytocin (OT) in regulating nociception in previously exposed (MS during early postnatal development) mice that were subjected to acute stress (restraint stress or RS). Further, we evaluated whether such modulation of pain sensation in MS mice are regulated by shared mechanisms of the OTergic and opioidergic systems...
November 30, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27930451/postexercise-hypotension-is-volume-dependent-in-hypertensives-autonomic-and-forearm-blood-responses
#3
Aline de Freitas Brito, Maria do Socorro Brasileiro Santos, Caio Victor Coutinho de Oliveira, Amilton da Cruz Santos
The purpose of this study was to investigate the short-term effect of kettlebell swings (KBSs) on lumbopelvic pressure pain thresholds (PPTs) in healthy adults. Sixty participants (male=23, female=37, mean age=25.12 years ±2.86, height=170.73 cm ± 9.2, mass=70.49 kg ± 13.32) were randomized into one of two groups. The experimental group performed a warm-up followed by eight consecutive 20-second rounds of KBS with 10-second rest periods. The control group performed the warm-up alone. An evaluator blinded to group assignment, assessed PPTs immediately before and after the intervention using a handheld pressure algometer...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27930448/the-short-term-effect-of-kettlebell-swings-on-lumbopelvic-pressure-pain-thresholds-a-randomized-controlled-trial
#4
Brandon M Keilman, William J Hanney, Morey J Kolber, Patrick S Pabian, Paul A Salamh, Carey E Rothschild, Xinliang Liu
The purpose of this study was to investigate the short-term effect of kettlebell swings (KBSs) on lumbopelvic pressure pain thresholds (PPTs) in healthy adults. Sixty participants (male=23, female=37, mean age=25.12 years ±2.86, height=170.73 cm ± 9.2, mass=70.49 kg ± 13.32) were randomized into one of two groups. The experimental group performed a warm-up followed by eight consecutive 20-second rounds of KBS with 10-second rest periods. The control group performed the warm-up alone. An evaluator blinded to group assignment, assessed PPTs immediately before and after the intervention using a handheld pressure algometer...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27930392/pain-catastrophizing-is-not-associated-with-spinal-nociceptive-processing-in-people-with-chronic-widespread-pain
#5
David A Rice, Rosalind S Parker, Gwyn N Lewis, Michal T Kluger, Peter J McNair
OBJECTIVES: Pain catastrophizing has been associated with higher pain intensity, increased risk of developing chronic pain and poorer outcomes after pain treatments. Despite this, the mechanisms by which pain catastrophizing influences pain remain poorly understood. It has been hypothesised that pain catastrophizing may impair descending inhibition of spinal level nociception. The aims of this study were to compare spinal nociceptive processing in people with chronic widespread pain and pain free controls and examine potential relationships between measures of pain catastrophizing and spinal nociception...
December 7, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27930390/a-novel-approach-for-the-control-of-inflammatory-pain-prostaglandin-e2-complexation-by-randomly-methylated-%C3%AE-cyclodextrins
#6
Reine-Solange Sauer, Heike Lydia Rittner, Norbert Roewer, Tamás Sohajda, Sergey Shityakov, Alexander Brack, Jens-Albert Broscheit
BACKGROUND: Inhibitors of cyclooxygenase, which block the formation of prostaglandin (PG) E2, are the standard treatment of inflammatory pain. These drugs, however, have serious gastrointestinal, renal, and cardiovascular side effects that limit their clinical use. Cyclodextrins are neutral glucose oligomers that form a hydrophilic outer and a hydrophobic interior cavity used to carry hydrophilic substances. Methyl-β-cyclodextrins are used currently in several drugs as enhancers and also to deliver PGs...
December 8, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27927495/the-substantial-clinical-benefit-threshold-for-srs-22r-domains-after-surgical-treatment-of-adult-spinal-deformity
#7
Charles H Crawford, Steven D Glassman, Keith H Bridwell, Leah Y Carreon
STUDY DESIGN: Longitudinal cohort. OBJECTIVES: To determine Substantial Clinical Benefit (SCB) thresholds for the SRS22R domains in patients undergoing adult spinal deformity surgery. SUMMARY OF BACKGROUND DATA: The Scoliosis Research Society 22R (SRS22R) has been shown to be reliable, valid, and responsive to change in adult spinal deformity patients. Although the minimal clinically important difference (MCID) is commonly used to quantify a threshold of improvement, it could be considered a floor value rather than a goal...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27926760/epidermal-nerve-fiber-quantification-in-patients-with-erythromelalgia
#8
William G Mantyh, P James B Dyck, Peter J Dyck, Janean K Engelstad, William J Litchy, Paola Sandroni, Mark D P Davis
Importance: Erythromelalgia is a clinical diagnosis based on intermittent warmth, erythema, and pain in the distal extremities. One problem facing physicians is how to objectively test for this disease. Given that other painful conditions of the distal extremities (ie, neuropathy related to human immunodeficiency virus, diabetes, or Fabry disease) can be evaluated with a skin biopsy to visualize pathologically decreased densities of the small nerve fibers that innervate the epidermis, one hypothesis is that erythromelalgia could similarly be associated with a loss of epidermal nerve fiber density (ENFD)...
December 7, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27924138/the-effects-of-a-multi-ingredient-supplement-on-markers-of-muscle-damage-and-inflammation-following-downhill-running-in-females
#9
Jessica L Köhne, Michael J Ormsbee, Andrew J McKune
BACKGROUND: The effects of a multi-ingredient performance supplement (MIPS) on markers of inflammation and muscle damage, perceived soreness and lower limb performance are unknown in endurance-trained female athletes. The purpose of this study was to determine the impact of MIPS (NO-Shotgun®) pre-loaded 4 weeks prior to a single-bout of downhill running (DHR) on hsC-Reactive Protein (hsCRP), interleukin (IL)-6, creatine kinase (CK), muscle soreness, lower limb circumferences and performance...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27923161/antinociceptive-tolerance-to-nsaids-in-the-rat-formalin-test-is-mediated-by-the-opioid-mechanism
#10
Nana Tsiklauri, Ivliane Nozadze, Gulnaz Gurtskaia, Merab G Tsagareli
BACKGROUND: In the past decade it has been shown that tolerance develops to the antinociceptive effect of repeated systemic administration of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) in acute pain models using rats. This is similar to the tolerance observed with opioid-induced analgesia. In the present study, we investigated the development of tolerance to the analgesic effects of NSAIDs diclofenac, ketorolac and xefocam in a chronic inflammatory pain model, the formalin test...
October 6, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27922760/nervecheck-for-the-detection-of-sensory-loss-and-neuropathic-pain-in-diabetes
#11
Georgios Ponirakis, Maria N Odriozola, Samantha Odriozola, Ioannis N Petropoulos, Shazli Azmi, Maryam Ferdousi, Hassan Fadavi, Uazman Alam, Andrew Marshall, Maria Jeziorska, Anthony Miro, Ahmad Kheyami, Mitra Tavakoli, Ahmed Al-Ahmar, Maria B Odriozola, Ariel Odriozola, Rayaz A Malik
BACKGROUND: Accurate and economic detection of nerve damage in diabetes is key to more widespread diagnosis of patients with diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy. This study examined the diagnostic performance of NerveCheck, an inexpensive ($500) quantitative sensory testing (QST) device. METHODS: One hundred forty-four subjects (74 with and 70 without diabetes) underwent assessment with NerveCheck, neuropathy disability score (NDS), nerve conduction studies (NCS), intraepidermal and corneal nerve fiber density (IENFD and CNFD), and McGill questionnaire for neuropathic pain...
December 6, 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27922579/srs-22r-scores-in-non-operated-adolescent-idiopathic-scoliosis-patients-with-curves-greater-than-forty-degrees
#12
W Timothy Ward, Nicole A Friel, Tanya S Kenkre, Maria M Brooks, Joanne A Londino, James W Roach
STUDY DESIGN: Case control comparative series OBJECTIVE.: Describe surgical range adolescent idiopathic scoliosis (AIS) patients electing to forgo surgery and compare health related quality of life outcomes to a similar cohort of operated AIS patients by the same single surgeon. SUMMARY OF BACKGROUND DATA: No data have been published either documenting SRS-22r scores of non-operated patients with curves ≥ 40° or comparing these scores to a demographically similar operated cohort...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27919822/astrocyte-contributes-to-pain-development-via-mmp2-jnk1-2-signaling-in-a-mouse-model-of-complex-regional-pain-syndrome
#13
Guogang Tian, Xin Luo, Chaoliang Tang, Xiang Cheng, Sookja Kim Chung, Zhengyuan Xia, Chi Wai Cheung, Qulian Guo
BACKGROUND: The activation of spinal glial cells (astrocyte and microglia) is reported in patient with complex regional pain syndrome (CRPS). However, the roles of spinal glial activities in the pathophysiology of CRPS are unclear. Here, we explored the roles of spinal astrocyte and microglia and the molecular mechanisms underlying CRPS using a mouse model of chronic post-ischemia pain (CPIP). RESULTS: CPIP injury increased the level of glial fibrillary acidic protein (GFAP, reactive astrocyte biomarker), but had no significant impact on ionized calcium binding adaptor molecule 1 (IBA1, reactive microglia biomarker), in the ipsilateral dorsal horn on post-injury day (PID) 3 when the pain threshold started to reduce significantly...
December 2, 2016: Life Sciences
https://www.readbyqxmd.com/read/27919774/understanding-facial-expressions-of-pain-in-patients-with-depression
#14
Stefan Lautenbacher, Karl-Juergen Bär, Patricia Eisold, Miriam Kunz
: Although depression is associated with more clinical pain complaints, psychophysical data sometimes point to hypoalgesic alterations. Studying the more reflex-like facial expression of pain in patients with depression may offer a new perspective. Facial and psychophysical responses to non-painful and painful heat stimuli were studied in 23 patients with major depressive disorder (MDD) and 23 matched controls. As psychophysical data, pain thresholds, tolerance thresholds and self-report were assessed...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27919773/analgesic-effects-of-alcohol-a-systematic-review-and-meta-analysis-of-controlled-experimental-studies-in-healthy-participants
#15
REVIEW
Trevor Thompson, Charlotte Oram, Christoph U Correll, Stella Tsermentseli, Brendon Stubbs
: Despite the long-standing belief in the analgesic properties of alcohol, experimental studies have produced mixed results. This meta-analysis aimed to clarify whether alcohol produces a decrease in experimentally-induced pain and to determine the magnitude of any such effect. PubMed, PsycINFO and Embase databases were searched from inception until 21/4/2016 for controlled studies examining the effect of quantified dosages of alcohol on pain response to noxious stimulation. Eighteen studies involving 404 participants were identified providing alcohol vs...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27919024/trigger-points-are-associated-with-widespread-pressure-pain-sensitivity-in-people-with-tension-type-headache
#16
María Palacios-Ceña, Kelun Wang, Matteo Castaldo, Amparo Guillem-Mesado, Carlos Ordás-Bandera, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate the association between trigger points (TrPs) and widespread pressure pain sensitivity in people with tension-type headache (TTH) and to determine if this association is different between frequent episodic (FETTH) or chronic (CTTH) headache. DESIGN: A cross-sectional study. METHODS: One hundred and fifty-seven individuals (29% male) with TTH participated. Clinical features of headache, i.e., intensity, duration, and frequency, were recorded in a headache diary...
November 14, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919023/does-pain-sensitivity-change-by-migraine-phase-a-blinded-longitudinal-study
#17
Martin Uglem, Petter Moe Omland, Kristian Bernhard Nilsen, Erling Tronvik, Lars Jacob Stovner, Knut Hagen, Mattias Linde, Trond Sand
OBJECTIVE: Studies suggest that pain thresholds may be altered before and during migraine headaches, but it is still debated if a central or peripheral dysfunction is responsible for the onset of pain in migraine. The present blinded longitudinal study explores alterations in thermal pain thresholds and suprathreshold heat pain scores before, during, and after headache. METHODS: We measured pain thresholds to cold and heat, and pain scores to 30 seconds of suprathreshold heat four times in 49 migraineurs and once in 31 controls...
November 15, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919018/trigeminal-nervous-system-sensitization-by-infraorbital-nerve-injury-enhances-responses-in-a-migraine-model
#18
Midori Toyama, Chiho Kudo, Chikako Mukai, Mika Inoue, Aiko Oyamaguchi, Hiroshi Hanamoto, Mitsutaka Sugimura, Hitoshi Niwa
BACKGROUND: Although the peripheral and central sensitizations of trigeminal nervous system may be one of the important factors of migraine, the precise mechanism is not fully understood. In this study, we examined the influence of the sensitization of the second division of the trigeminal nerve (V2) by chronic constriction injury (CCI) of the infraorbital nerve (ION) on migraine headache, using the capsaicin-induced migraine model. METHODS: Male Sprague-Dawley rats were assigned to four groups: (a) sham surgery and topical-dural vehicle application (Sham + Vehicle) group, (b) CCI-ION and topical-dural vehicle application (CCI-ION + Vehicle) group, (c) sham surgery and topical-dural capsaicin application (Sham + Capsaicin) group, (d) CCI-ION and topical-dural capsaicin application (CCI-ION + Capsaicin) group...
November 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27917764/diabetic-cachectic-neuropathy-an-uncommon-neurological-complication-of-diabetes
#19
A Iyagba, A Onwuchekwa
A 40-year-old female patient with diabetes of 12 years' duration, with poor drug compliance, presented with a 4-month history of rapid progressive weight loss, burning sensations in the feet, abdominal swelling, and constipation with occasional episodes of epigastric pain. On examination, she was chronically ill-looking with a body mass index of 17.1 kg/m2, grossly distended abdomen (initially mistaken for gravid abdomen). Blood pressure measurements in the supine and standing positions were 200/130 mmHg and 180/100 mmHg, respectively...
December 1, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27916555/adx71943-and-adx71441-novel-positive-allosteric-modulators-of-the-gabab-receptor-with-distinct-central-peripheral-profiles-show-efficacy-in-the-monosodium-iodoacetate-model-of-chronic-osteoarthritis-pain-in-the-rat
#20
Mikhail Kalinichev, Tansy Donovan-Rodriguez, Françoise Girard, Hasnaá Haddouk, Isabelle Royer-Urios, Manfred Schneider, Simon T Bate, Cheryl Marker, James D Pomonis, Sonia Poli
We tested novel positive allosteric modulators (PAMs) of the γ-aminobutyric acid receptor B (GABAB), ADX71943 and ADX71441in the monosodium iodoacetate model of chronic osteoarthritis pain in rats with the objective to delineate the role of peripheral versus central GABAB receptor populations in modulation of chronic pain. Anesthetized Sprague-Dawley rats received an injection of monosodium iodoacetate into the knee and were tested for hyperalgesia starting post-MIA day 14. Effects of compounds on ipsilateral joint compression threshold were evaluated on post-MIA day 14 (after acute treatment), as well as after repeated, daily treatment on days 21 and 28 (ADX71943 only) and were compared to those of celecoxib (30mg/kg, p...
December 1, 2016: European Journal of Pharmacology
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