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Keywords Hepatocellular intervention th...

Hepatocellular intervention therapy

https://read.qxmd.com/read/38417061/the-perioperative-experience-and-needs-of-hepatocellular-carcinoma-patients-in-interventional-therapy-a-phenomenological-qualitative-study
#21
JOURNAL ARTICLE
Ling Li, Hua-Zhen Zhang, Yan Ge, Ya-Li Rao, Ting Liu, Miao-Miao Guo, Shu-Ping Xiao
OBJECTIVE: This study aims to investigate the perioperative experience and needs of patients with liver cancer for interventional therapy, in order to provide the basis for further improving a patient's medical experience and satisfaction. METHODS: A semi-structured in-depth interview was conducted for 16 patients with liver cancer in interventional therapy using the phenomenological research method of qualitative research. The themes were analyzed, summarized, refined and extracted using the Colaizzi analytical procedure...
April 1, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38397869/pan-cancer-analysis-reveals-disulfidoptosis-associated-genes-as-promising-immunotherapeutic-targets-insights-gained-from-bulk-omics-and-single-cell-sequencing-validation
#22
JOURNAL ARTICLE
Borui Xu, Minghao Li, Nuoqing Weng, Chuzhou Zhou, Yinghui Chen, Jinhuan Wei, Liangmin Fu
Disulfidoptosis, a novel form of cell death, is distinct from other well-known cell death mechanisms. Consequently, a profound investigation into disulfidoptosis elucidates the fundamental mechanisms underlying tumorigenesis, presenting promising avenues for therapeutic intervention. Comprehensive analysis of disulfidoptosis-associated gene (DRG) expression in pan cancer utilized TCGA, GEO, and ICGC datasets, including survival and Cox-regression analyses for prognostic evaluation. We analyzed the association between DRG expression and both immune cell infiltration and immune-related gene expression using the ESTIMATE and TISDIB datasets...
January 24, 2024: Biomedicines
https://read.qxmd.com/read/38384805/a-novel-nomogram-to-predict-the-overall-survival-of-early-stage-hepatocellular-carcinoma-patients-following-ablation-therapy
#23
JOURNAL ARTICLE
Honghai Zhang, Shugui Sheng, Wenying Qiao, Ming Han, Ronghua Jin
INTRODUCTION: This study aimed to assess factors affecting the prognosis of early-stage hepatocellular carcinoma (HCC) patients undergoing ablation therapy and create a nomogram for predicting their 3-, 5-, and 8-year overall survival (OS). METHODS: The research included 881 early-stage HCC patients treated at Beijing You'an Hospital, affiliated with Capital Medical University, from 2014 to 2022. A nomogram was developed using independent prognostic factors identified by Lasso and multivariate Cox regression analyses...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38382930/neoadjuvant-therapies-in-resectable-hepatocellular-carcinoma-exploring-strategies-to-improve-prognosis
#24
JOURNAL ARTICLE
Ya-Nan Ma, Xuemei Jiang, Peipei Song, Wei Tang
Hepatocellular carcinoma (HCC), a challenging malignancy, often necessitates surgical intervention, notably liver resection. However, the high recurrence rate, reaching 70% within 5 years post-resection, significantly impacts patient outcomes. Neoadjuvant therapies aim to preoperatively address this challenge, reducing lesion size, improving surgical resection rates, deactivating potential micro-metastases, and ultimately lowering postoperative recurrence rates. This review concentrates on advances in research on and clinical use of neoadjuvant therapies for HCC, with particular attention to the use of immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)...
February 20, 2024: Bioscience Trends
https://read.qxmd.com/read/38372059/prehabilitation-programs-in-liver-resection-a-narrative-review
#25
JOURNAL ARTICLE
En Qi Toh, Hoi Pong Nicholas Wong, Jia Dong James Wang, Matthias Yi Quan Liau, Yi Fang Tan, Vishalkumar Girishchandra Shelat
BACKGROUND AND OBJECTIVE: Liver resection (LR) is a commonly performed surgical procedure for the management of hepatocellular carcinoma and other liver conditions. Despite its benefits in providing patients a potential cure, it is also associated with significant postoperative complications and prolonged recovery periods. In recent years, pre-operative rehabilitation (prehabilitation) has emerged as an up-and-coming strategy to optimize patients' physical, psychological and functional status before LR, leading to improved surgical and patient postoperative outcomes...
February 2, 2024: Chinese Clinical Oncology
https://read.qxmd.com/read/38368771/anti-pd-1-therapy-reverses-tigit-cd226-nk-depletion-in-immunotherapy-resistance-of-hepatocellular-carcinoma-through-pvr-tigit-pathway
#26
JOURNAL ARTICLE
Jing Wang, Lin Yang, Han-Xuan Wang, Song-Ping Cui, Ya Gao, Bin Hu, Lin Zhou, Ren Lang
Immunotherapy resistance conducts the main reason for failure of PD-1-based immune checkpoint inhibitors (ICIs) in patients with hepatocellular carcinoma (HCC). This study aims to clarify the mechanism of nature kill cells (NK) depletion in immunotherapy resistance of HCC. Cancerous /paracancerous tissues and peripheral blood (PB) of 55 HCC patients were collected and grouped according to differentiation degree, FCM, IHC and lymphocyte culture drug intervention experiments were used to determine NK cell depletion degree...
February 17, 2024: International Immunopharmacology
https://read.qxmd.com/read/38351900/effect-of-comprehensive-nursing-care-for-the-liver-cancer-patients-undergoing-interventional-therapy-in-china-a-systematic-review-and-meta-analysis
#27
JOURNAL ARTICLE
Shimei Zhang, Na Li, Xuying Mao, Dongxia Yang
AIMS: This review aims to assess the effect of comprehensive nursing care on liver cancer patients undergoing interventional therapy in China. METHODS: In accordance with PRISMA guidelines, we reviewed randomized controlled trials and observational studies assessing the effect of comprehensive nursing care against standard care on liver cancer patients undergoing specific interventional therapies in China, including PubMed, Embase, CENTRAL and CINAHL till June 2023...
February 14, 2024: International Journal of Nursing Practice
https://read.qxmd.com/read/38342221/radioembolization-plus-immune-checkpoint-inhibitor-therapy-compared-to-radioembolization-plus-tyrosine-kinase-inhibitor-therapy-for-the-treatment-of-hepatocellular-carcinoma
#28
JOURNAL ARTICLE
Kirema Garcia-Reyes, Ricki A Gottlieb, Kartikeya M Menon, Vivian Bishay, Rahul Patel, Rajesh Patel, Scott Nowakowski, Max W Sung, Thomas U Marron, William H Gansa, Jack Zhang, Sahitya C Raja, Daniel Shilo, Aaron Fischman, Robert Lookstein, Edward Kim
PURPOSE: To investigate if combination therapy with immune checkpoint inhibitor (ICI) and Y90 radioembolization results in superior outcomes than tyrosine kinase inhibitor (TKI) therapy and Y90 for the treatment of intermediate-to-advanced stage hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A retrospective review of patients presented at an institutional multidisciplinary liver tumor board between 1/1/2012-8/1/2023 was conducted. Forty-four patients with HCC who underwent Y90 4-weeks within initiation of ICI or TKI therapy were included...
February 9, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38339417/management-of-hepatocellular-carcinoma-in-2024-the-multidisciplinary-paradigm-in-an-evolving-treatment-landscape
#29
REVIEW
Emily Kinsey, Hannah M Lee
Liver cancer is the third most common cause of cancer-related deaths worldwide, and hepatocellular carcinoma (HCC) makes up the majority of liver cancer cases. Despite the stabilization of incidence rates in recent years due to effective viral hepatitis treatments, as well as improved outcomes from early detection and treatment advances, the burden of HCC is anticipated to rise again due to increasing rates of metabolic dysfunction-associated steatotic liver disease and alcohol-related liver disease. The treatment landscape is evolving and requires a multidisciplinary approach, often involving multi-modal treatments that include surgical resection, transplantation, local regional therapies, and systemic treatments...
February 4, 2024: Cancers
https://read.qxmd.com/read/38334817/surveillance-of-the-liver-in-type-2-diabetes-important-but-unfeasible
#30
REVIEW
Sami Qadri, Hannele Yki-Järvinen
Fatty liver plays a pivotal role in the pathogenesis of the metabolic syndrome and type 2 diabetes. According to an updated classification, any individual with liver steatosis and one or more features of the metabolic syndrome, without excess alcohol consumption or other known causes of steatosis, has metabolic dysfunction-associated steatotic liver disease (MASLD). Up to 60-70% of all individuals with type 2 diabetes have MASLD. However, the prevalence of advanced liver fibrosis in type 2 diabetes remains uncertain, with reported estimates of 10-20% relying on imaging tests and likely overestimating the true prevalence...
February 9, 2024: Diabetologia
https://read.qxmd.com/read/38334275/implementation-of-a-hepatocellular-carcinoma-surveillance-program-in-a-community-based-integrated-health-system-in-patients-with-hepatitis-c-cirrhosis
#31
JOURNAL ARTICLE
Hien Bui, Nikhilesh G Kumar, Amit G Singal, Jasdeep Boparai, Don Tran, Nizar A Mukhtar, Varun Saxena, Sripriya Balasubramanian
BACKGROUND: Underutilization of hepatocellular cancer (HCC) surveillance has been reported, although data evaluating interventions to improve surveillance are sparse. We assessed the effect of a population-based HCC surveillance program on HCC surveillance utilization and outcomes. METHODS: In this retrospective cohort study, we assessed pre- and post-inclusion HCC surveillance patterns among 597 patients with HCV cirrhosis enrolled in a program at an integrated health system between 2013-20...
February 9, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38328333/unraveling-the-efficacy-network-a-network-meta-analysis-of-adjuvant-external-beam-radiation-therapy-methods-after-hepatectomy
#32
REVIEW
Gao-Yuan Yang, Zhi-Wei He, Yong-Chang Tang, Feng Yuan, Ming-Bo Cao, Yu-Peng Ren, Yu-Xuan Li, Xiao-Rui Su, Zhi-Cheng Yao, Mei-Hai Deng
BACKGROUND: Primary liver cancer is a malignant tumor with a high recurrence rate that significantly affects patient prognosis. Postoperative adjuvant external radiation therapy (RT) has been shown to effectively prevent recurrence after liver cancer resection. However, there are multiple RT techniques available, and the differential effects of these techniques in preventing postoperative liver cancer recurrence require further investigation. AIM: To assess the advantages and disadvantages of various adjuvant external RT methods after liver resection based on overall survival (OS) and disease-free survival (DFS) and to determine the optimal strategy...
January 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38326045/-analysis-of-the-experience-and-procedural-complications-of-trans-radial-access-versus-trans-femoral-access-for-hepatic-arterial-perfusion-chemotherapy-in-patients-with-advanced-hepatic-malignancies-a-retrospective-study
#33
JOURNAL ARTICLE
T Y Lyu, M Li, J A He, Q F Sun, L Wang, H Qin, H P Yu
Objective: To analyze the differences between trans-radial access (TRA) and trans-femoral access (TFA) in hepatic arterial perfusion chemotherapy (HAIC) in terms of patient experience, postoperative complications, and patient preferences; explore whether TRA in HAIC is associated with better patient experience and compliance; and determine whether it is safer than TFA. Methods: The study was a retrospective cohort study of patients with advanced hepatocellular carcinoma and liver metastases from colorectal cancer treated with HAIC...
February 1, 2024: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/38320622/hepatocellular-carcinoma-epigenetic-patterns-correspond-to-differences-in-ethnoracial-status-and-treatment-response
#34
JOURNAL ARTICLE
Vishwaarth Vijayakumar, Ron C Gaba, Yu-Hui Huang, Isaiah Davis, Ricardo Roman, Grace Guzman, R Peter Lokken, Kyle M Schachtschneider
PURPOSE: To correlate epigenetic patterns to ethnoracial status and locoregional therapy (LRT) response in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Deoxyribo- (DNA) and ribonucleic acid (RNA) were extracted from 47 distinct formalin-fixed paraffin-embedded tumor samples from 42 HCC patients (n=14 Black, n=19 White, n=9 Hispanic). LRT response was determined using computed tomography or magnetic resonance imaging 3 months post-treatment of 35 tumors (n=22 complete response, n=13 retreatment candidates)...
February 4, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38320351/enhanced-nk-cell-activation-via-eef2k-mediated-potentiation-of-the-cgas-sting-pathway-in-hepatocellular-carcinoma
#35
JOURNAL ARTICLE
Yan Xu, Fang Sun, Yuying Tian, Guineng Zeng, Guanglin Lei, Zhifang Bai, Yonggang Wang, Xinlan Ge, Jing Wang, Chaohui Xiao, Zhaohai Wang, Minggen Hu, Jianxun Song, Penghui Yang, Rong Liu
BACKGROUND: Liver cancer, particularly hepatocellular carcinoma (HCC), is characterized by a high mortality rate, attributed primarily to the establishment of an immunosuppressive microenvironment. Within this context, we aimed to elucidate the pivotal role of eukaryotic elongation factor 2 kinase (eEF2K) in orchestrating the infiltration and activation of natural killer (NK) cells within the HCC tumor microenvironment. By shedding light on the immunomodulatory mechanisms at play, our findings should clarify HCC pathogenesis and help identify potential therapeutic intervention venues...
February 5, 2024: International Immunopharmacology
https://read.qxmd.com/read/38318160/hepatocellular-carcinoma-signaling-pathways-targeted-therapy-and-immunotherapy
#36
REVIEW
Xiaoting Luo, Xin He, Xingmei Zhang, Xiaohui Zhao, Yuzhe Zhang, Yusheng Shi, Shengni Hua
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a high mortality rate. It is regarded as a significant public health issue because of its complicated pathophysiology, high metastasis, and recurrence rates. There are no obvious symptoms in the early stage of HCC, which often leads to delays in diagnosis. Traditional treatment methods such as surgical resection, radiotherapy, chemotherapy, and interventional therapies have limited therapeutic effects for HCC patients with recurrence or metastasis...
February 2024: MedComm
https://read.qxmd.com/read/38312669/recent-advances-of-novel-targeted-drug-delivery-systems-based-on-natural-medicine-monomers-against-hepatocellular-carcinoma
#37
REVIEW
Guanjie Ji, Yue Li, Zhiyue Zhang, Hui Li, Ping Sun
Hepatocellular carcinoma (HCC), the most prevalent type of liver cancer, is often diagnosed at an advanced stage. Surgical interventions are often ineffective, leading HCC patients to rely on systemic chemotherapy. Unfortunately, commonly used chemotherapeutic drugs have limited efficacy and can adversely affect vital organs, causing significant physical and psychological distress for patients. Natural medicine monomers (NMMs) have shown promising efficacy and safety profiles in HCC treatment, garnering attention from researchers...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38312647/paeoniflorin-increases-the-anti-tumor-efficacy-of-sorafenib-in-tumor-bearing-mice-with-liver-cancer-via-suppressing-the-nf-%C3%AE%C2%BAb-pd-l1-axis
#38
JOURNAL ARTICLE
Junfei Li, Chenghui Zhu, Zengyu Zhang, Xiaorong Zheng, Chunlei Wang, Hongyan Zhang
BACKGROUND: Sorafenib (Sor) represents a first-line therapy for hepatocellular carcinoma (HCC); however, its efficacy is constrained by secondary failure, which limits its clinical use. Recent studies have indicated that the suppression of Programmed cell death-Ligand 1 (PD-L1) may potentiate Sor's anti-liver cancer effects; furthermore, PD-L1 expression is known to be regulated by NF-κB. Previous research has demonstrated that paeoniflorin (PF) downregulates the NF-κB axis, nevertheless, current research has not yet determined whether PF can synergistically enhance the efficacy of Sor against HCC by modulating the NF-κB/PD-L1 pathway...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38291698/budd-chiari-syndrome-in-children-radiological-intervention-and-role-of-shear-wave-elastography-in-monitoring-response
#39
JOURNAL ARTICLE
Arghya Samanta, Anshu Srivastava, Rajnikant Yadav, Aditya Kapoor, Anindya Ghosh, Prabhakar Mishra, Moinak Sen Sarma, Ujjal Poddar
OBJECTIVES: Radiological intervention (RI) is the preferred treatment in children with Budd-Chiari syndrome (BCS). We studied the comparative long-term outcome of BCS children, with and without RI and utility of liver and splenic stiffness measurement (LSM, SSM) by 2-dimensional shear wave elastography (2D-SWE) in assessing response. METHODS: Sixty children (40 boys, median age 10.5 [6.5-15.25] years) with BCS (29 newly diagnosed, 31 follow-up) were evaluated. LSM and SSM by 2D-SWE and vascular patency were monitored pre- and postprocedure (≥ 6 months postprocedure) in those undergoing RI...
January 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38291158/transarterial-chemoembolization-plus-tyrosinkinase-inhibitors-and-pd-1-inhibitors-for-spontaneously-ruptured-hepatocellular-carcinoma
#40
JOURNAL ARTICLE
Jie Ji, Chun Zhou, Le-le Yan, Yuan Ma, Chuan Xu, Fu-An Wang, Wei-Zhong Zhou, Peng-Hua Lv
PURPOSE: To compare the efficacy and safety of transcatheter arterial chemoembolization (TACE) in combination with tyrosinkinase inhibitors (TKI) and PD-1 inhibitors, versus TACE monotherapy for the treatment of ruptured hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This study included 104 patients with ruptured HCC receiving either combination therapy or TACE monotherapy at two centers between June 2015 and June 2022. Propensity score matching (PSM) analysis was used at a 1:2 ratio to reduce bias between the two groups...
January 30, 2024: Cardiovascular and Interventional Radiology
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