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https://www.readbyqxmd.com/read/29789277/applicability-of-a-web-based-individualized-exercise-intervention-in-patients-with-liver-disease-cystic-fibrosis-esophageal-cancer-and-psychiatric-disorders-process-evaluation-of-4-ongoing-clinical-trials
#1
Daniel Pfirrmann, Nils Haller, Yvonne Huber, Patrick Jung, Klaus Lieb, Ines Gockel, Krystyna Poplawska, Jörn Markus Schattenberg, Perikles Simon
BACKGROUND: In the primary and secondary prevention of civilization diseases, regular physical activity is recommended in international guidelines to improve disease-related symptoms, delay the progression of the disease, or to enhance postoperative outcomes. In the preoperative context, there has been a paradigm shift in favor of using preconditioning concepts before surgery. Web-based interventions seem an innovative and effective tool for delivering general information, individualized exercise recommendations, and peer support...
May 22, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29777749/burden-of-liver-disease-in-europe-epidemiology-and-analysis-of-risk-factors-to-identify-prevention-policies
#2
REVIEW
Laura Pimpin, Helena Cortez-Pinto, Francesco Negro, Emily Corbould, Jeffrey V Lazarus, Laura Webber, Nick Sheron
BACKGROUND & AIMS: The burden of liver disease in Europe continues to grow. We aimed to describe the epidemiology of liver diseases and their risk factors in European countries, and identify public health interventions that could impact on these risk factors to reduce the burden of liver disease. METHODS: As part of the HEPAHEALTH project, commissioned by EASL, we extracted information on historical and current prevalence and mortality from national and international literature and databases on liver disease in 35 countries in the WHO European region, as well as historical and recent prevalence data on their main determinants; alcohol consumption, obesity and hepatitis B and C virus infections...
May 16, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29769113/thinking-beyond-opisthorchis-viverrini-for-risk-of-cholangiocarcinoma-in-the-lower-mekong-region-a-systematic-review-and-meta-analysis
#3
REVIEW
Jennifer A Steele, Carsten H Richter, Pierre Echaubard, Parichat Saenna, Virginia Stout, Paiboon Sithithaworn, Bruce A Wilcox
BACKGROUND: Cholangiocarcinoma (CCA) is a fatal bile duct cancer associated with infection by the liver fluke, Opisthorchis viverrini, in the lower Mekong region. Numerous public health interventions have focused on reducing exposure to O. viverrini, but incidence of CCA in the region remains high. While this may indicate the inefficacy of public health interventions due to complex social and cultural factors, it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of CCA...
May 17, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29767833/post-operative-care-of-interventional-therapy-for-40-liver-cancer-patients-with-obstructive-jaundice
#4
De-Ping Tong, Li-Qin Wu, Xiao-Ping Chen, Yi Li
The care of 40 patients with primary liver cancer with obstructive jaundice treated with liver puncture bile drainage or biliary stent implantation was reported. Treated with the interventional therapy, patients were observed closely to identify symptoms of hepatic encephalopathy and pain; diet care was well performed. Bile drainage tube and skin acre were performed carefully. Liver function, bilirubin and other biochemical indicators were monitored; occurrence of bleeding, acute pancreatitis, biliary tract infection, leakage of ascites around drainage tube and other complication were observed with good discharge instruction...
May 16, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29743015/mortality-trends-among-people-with-hepatitis-b-and-c-a-population-based-linkage-study-1993-2012
#5
Maryam Alavi, Jason Grebely, Behzad Hajarizadeh, Janaki Amin, Sarah Larney, Matthew G Law, Jacob George, Louisa Degenhardt, Gregory J Dore
BACKGROUND: This study evaluated cause-specific mortality trends including liver-related mortality among people with a hepatitis B virus (HBV) and hepatitis C virus (HCV) notification in New South Wales, Australia. METHODS: Notifications 1993-2012 were linked to cause-specific mortality records 1993-2013. RESULTS: Among 57,929 and 92,474 people with a HBV and HCV notification, 4.8% and 10.0% died since 1997. In early 2010s, 28% and 33% of HBV and HCV deaths were liver-related, 28% and 17% were cancer-related (excluding liver cancer), and 5% and 15% were drug-related, respectively...
May 9, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29740687/radioembolisation-in-europe-a-survey-amongst-cirse-members
#6
Margot T M Reinders, Etienne Mees, Maciej J Powerski, Rutger C G Bruijnen, Maurice A A J van den Bosch, Marnix G E H Lam, Maarten L J Smits
INTRODUCTION: Radioembolisation of liver tumours demands many choices from the physician regarding planning of treatment and subsequent follow-up. METHODS: An online questionnaire was distributed amongst all members of the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) to investigate the current state of radioembolisation practice. RESULTS: The survey was completed by 60 centres. The increasing number of radioembolisation procedures may reflect that radioembolisation is increasingly recognised as a valuable treatment option in European cancer guidelines...
May 8, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29740540/signaling-pathways-regulating-redox-balance-in-cancer-metabolism
#7
REVIEW
Maria Chiara De Santis, Paolo Ettore Porporato, Miriam Martini, Andrea Morandi
The interplay between rewiring tumor metabolism and oncogenic driver mutations is only beginning to be appreciated. Metabolic deregulation has been described for decades as a bystander effect of genomic aberrations. However, for the biology of malignant cells, metabolic reprogramming is essential to tackle a harsh environment, including nutrient deprivation, reactive oxygen species production, and oxygen withdrawal. Besides the well-investigated glycolytic metabolism, it is emerging that several other metabolic fluxes are relevant for tumorigenesis in supporting redox balance, most notably pentose phosphate pathway, folate, and mitochondrial metabolism...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29739453/spontaneous-renal-hemorrhage-secondary-to-choriocarcinoma-in-a-man-with-congenital-hypospadias-and-cryptorchidism-a-case-report-and-literature-review
#8
Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-Yu Xiong, Zi-Yi Yang, Yun-Xiao Zhu, Nathan Jeffreys
BACKGROUND: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. We present what we believe to be the first case of a male patient with genital malformation (hypospadias and cryptorchidism) and SRH at presentation of choriocarcinoma. CASE PRESENTATION: A 25-year-old man presented to the department with intense pain in the right flank region and lower back...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29737954/-90-y-radioembolization-for-hepatic-malignancy-in-patients-with-previous-biliary-intervention-multicenter-analysis-of-hepatobiliary-infections
#9
Kavi K Devulapalli, Nicholas Fidelman, Michael C Soulen, Matthew Miller, Matthew S Johnson, Eric Addo, Ghassan El-Haddad, Charles Nutting, James Morrison, Khashayar Farsad, R Peter Lokken, Ron C Gaba, Jacob Fleming, Daniel B Brown, Sharon W Kwan, Steven C Rose, Kevin A Pennycooke, David M Liu, Sarah B White, Ripal Gandhi, Ann A Lazar, Robert K Kerlan
Purpose To determine the frequency of hepatobiliary infections after transarterial radioembolization (TARE) with yttrium 90 (90 Y) in patients with liver malignancy and a history of biliary intervention. Materials and Methods For this retrospective study, records of all consecutive patients with liver malignancy and history of biliary intervention treated with TARE at 14 centers between 2005 and 2015 were reviewed. Data regarding liver function, 90 Y dosimetry, antibiotic prophylaxis, and bowel preparation prophylaxis were collected...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29733012/robotic-approach-in-benign-and-malignant-esophageal-tumors-a-preliminary-seven-case-series
#10
Victor Tomulescu, Codrut Stanescu, Cristian Blajut, Loredana Barbulescu, Gabriela Droc, Vlad Herlea, Irinel Popescu
Esophageal surgery has been recognized as very challenging for surgeons and risky for patients. Thoracoscopic approach have proved its benefit in esophageal surgery but has some drawbacks as tremor and limited degrees of freedom, contra-intuitive movements and fulcrum effect of the surgical tools. Robotic technology has been developed with the intent to overcome these limitations of the standard laparoscopy or thoracoscopy. These benefits of robotic procedure are most advantageous when operating in remote areas difficult to reach as in esophageal surgery...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29720474/functional-and-genomic-characterization-of-a-xenograft-model-system-for-the-study-of-metastasis-in-triple-negative-breast-cancer
#11
Cameron N Johnstone, Andrew D Pattison, Kylie L Gorringe, Paul F Harrison, David R Powell, Peter Lock, David Baloyan, M Ernst, Alastair G Stewart, Traude H Beilharz, Robin L Anderson
Triple-negative breast cancer represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes. Hence, new molecular targets for therapeutic intervention are necessary. Analyses of panels of human or mouse cancer lines derived from the same individual that differ in their cellular phenotypes but not in genetic background have been instrumental in defining the molecular players that drive the various hallmarks of cancer.To determine the molecular regulators of metastasis in triple-negative breast cancer, we completed a rigorous in vitro and in vivo characterization of four populations of the MDA-MB-231 human breast cancer line ranging in aggressiveness from non-metastatic to spontaneously metastatic to lung, liver, spleen and lymph node...
April 30, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29713629/helminths-and-cancers-from-the-evolutionary-perspective
#12
REVIEW
Larissa L S Scholte, Marcelo A Pascoal-Xavier, Laila A Nahum
Helminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes ( Schistosoma haematobium, Schistosoma japonicum , and Schistosoma mansoni ) and liver flukes ( Clonorchis sinensis and Opisthorchis viverrini ) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Our main goals are to summarize the current knowledge of human cancers caused by Platyhelminthes, point out some helminth and human biomarkers identified so far, and highlight the potential contributions of phylogenetics and molecular evolution to cancer research...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29705790/immunotherapy-of-hepatocellular-carcinoma
#13
Bernd Heinrich, Carolin Czauderna, Jens U Marquardt
Hepatocellular carcinoma (HCC) is one of the most deadly and rapidly evolving cancers worldwide. The current systemic treatment strategies in advanced tumor stages remain limited despite promising preclinical and early-phase clinical results for some compounds, highlighting an unmet clinical need. Since the majority of HCCs evolve in the background of a chronic inflammatory liver damage, HCCs can be considered a paradigm for inflammation-induced cancers, which renders immunotherapeutic strategies particularly promising for this tumor entity...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29704586/histologic-and-oncologic-outcomes-following-liver-mass-resection-with-retroperitoneal-lymph-node-dissection-in-patients-with-non-seminomatous-germ-cell-tumor
#14
Eugene J Pietzak, Melissa Assel, Maria F Becerra, Daniel Tennenbaum, Darren R Feldman, Dean F Bajorin, Robert J Motzer, George J Bosl, Brett S Carver, Daniel D Sjoberg, Joel Sheinfeld
OBJECTIVE: To evaluate the oncologic outcomes and histologic concordance of post-chemotherapy residual liver mass resection with post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND). METHODS: Retrospective review of our prospectively maintained germ cell tumor (GCT) surgical database identified patients with non-seminomatous GCT (NSGCT) who underwent both post-chemotherapy residual liver mass resection and PC-RPLND between 1990 and 2015. RESULTS: A total of 36 patients were identified, of whom 29 (81%) presented with a liver mass at initial diagnosis and 17 (47%) received second-line chemotherapy prior to liver resection...
April 25, 2018: Urology
https://www.readbyqxmd.com/read/29700559/-primary-sclerosing-cholangitis-current-diagnostics-and-treatment
#15
REVIEW
T Liwinski, C Schramm
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown etiology. Characteristic features are multifocal strictures and dilatations of the bile ducts. In 60-80 % of cases the PSC is strongly associated with chronic inflammatory bowel disease, mostly in the form of pancolitis. The diagnosis is established based on detection of typical cholangiographic lesions of the bile ducts and exclusion of secondary causes of sclerosing cholangitis. There is no approved medical treatment, but in Germany ursodeoxycholic acid is frequently used...
April 26, 2018: Der Internist
https://www.readbyqxmd.com/read/29699606/insulin-receptor-substrate-2-a-bridge-between-hippo-and-akt-pathways
#16
Sun-Hye Jeong, Dae-Sik Lim
NAFLD induces the development of advanced liver diseases such as NASH and liver cancer. Therefore, understanding the mechanism of NAFLD development is critical for its prevention and treatment. Ablation of PTEN or Hippo pathway components induces liver cancer in a murine model by hyperactive AKT or YAP/TAZ, respectively. Although the regulation of these two pathways occurs in the same hepatocyte, the details of crosstalk between Hippo-YAP/TAZ and PTEN-AKT pathways in liver homeostasis and tumorigenesis still remain unclear...
April 27, 2018: BMB Reports
https://www.readbyqxmd.com/read/29699534/high-prevalence-of-hepatitis-b-infections-in-burkina-faso-1996-2017-a-systematic-review-with-meta-analysis-of-epidemiological-studies
#17
Moussa Lingani, Tomoyuki Akita, Serge Ouoba, Armel Moumini Sanou, Aya Sugiyama, Zekiba Tarnagda, Masayuki Ohisa, Halidou Tinto, Shunji Mishiro, Junko Tanaka
BACKGROUND: Hepatitis B virus (HBV) infection was long considered an important public health concern in Burkina Faso and still represents a major cause of liver cancer and cirrhosis in the active population. To counter the problem, a national strategic plan was developed and adopted in July 2017 to coordinate viral hepatitis elimination's efforts. However evidence to support its implementation remains scanty and scattered. The main purpose of this study was to summarize available information from per-reviewed articles published over the last two decades to accurately estimate the prevalence of HBV infection in Burkina Faso...
April 25, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29696193/a-prospective-development-study-of-software-guided-radio-frequency-ablation-of-primary-and-secondary-liver-tumors-clinical-intervention-modelling-planning-and-proof-for-ablation-cancer-treatment-clinicimppact
#18
Martin Reinhardt, Philipp Brandmaier, Daniel Seider, Marina Kolesnik, Sjoerd Jenniskens, Roberto Blanco Sequeiros, Martin Eibisberger, Philip Voglreiter, Ronan Flanagan, Panchatcharam Mariappan, Harald Busse, Michael Moche
Introduction: Radio-frequency ablation (RFA) is a promising minimal-invasive treatment option for early liver cancer, however monitoring or predicting the size of the resulting tissue necrosis during the RFA-procedure is a challenging task, potentially resulting in a significant rate of under- or over treatments. Currently there is no reliable lesion size prediction method commercially available. Objectives: ClinicIMPPACT is designed as multicenter-, prospective-, non-randomized clinical trial to evaluate the accuracy and efficiency of innovative planning and simulation software...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29693248/risk-for-virus-and-non-virus-related-malignancies-following-immunosuppression-in-a-cohort-of-liver-transplant-recipients-italy-1985-2014
#19
Martina Taborelli, Pierluca Piselli, Giuseppe Maria Ettorre, Augusto Lauro, Laura Galatioto, Umberto Baccarani, Maria Rendina, Sarah Shalaby, Raffaella Petrara, Francesco Nudo, Luca Toti, Daniele Sforza, Giovanni Fantola, Claudia Cimaglia, Alessandro Agresta, Giovanni Vennarecci, Antonio Daniele Pinna, Salvatore Gruttadauria, Andrea Risaliti, Alfredo Di Leo, Patrizia Burra, Massimo Rossi, Giuseppe Tisone, Fausto Zamboni, Diego Serraino
This cohort study assessed, in Italy, the overall pattern of risk for de novo malignancies following liver transplantation (LT). The study group included 2832 individuals who underwent LT between 1985 and 2014 in nine centres throughout all of Italy. Person-years (PYs) at cancer risk were computed from 30 days after LT to the date of cancer diagnosis, to the date of death, or to the end of follow-up. Excess cancer risk, as compared to the general population, was estimated using standardized incidence ratios (SIRs) and 95% confidence intervals (CIs)...
April 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#20
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
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