keyword
https://read.qxmd.com/read/38497403/analysing-the-genetic-diversity-of-three-sheep-breeds-in-turkey-and-nearby-countries-using-50-k-snps-data
#21
JOURNAL ARTICLE
Mervan Bayraktar
This study analysed the genetic diversity and population structure of eight sheep breeds in Turkey and nearby countries. Moderate genetic diversity was observed, with the Sakiz (SKZ) exhibiting the highest diversity based on heterozygosity and allelic richness (AR) values. Genetic distances revealed differentiation between the populations, with the most significant divergence between the Cyprus Fat Tail (CFT) and SKZ breeds. PCA demonstrated SKZ and Chios (CHI) clustering together, indicating genetic similarity...
March 18, 2024: Animal Biotechnology
https://read.qxmd.com/read/38496461/effects-of-electroconvulsive-shock-on-the-function-circuitry-and-transcriptome-of-dentate-gyrus-granule-neurons
#22
Adrienne N Santiago, Julia Castello-Saval, Phi Nguyen, Hannah M Chung, Victor M Luna, Rene Hen, Wei-Li Chang
Therapeutic use of electroconvulsive shock (ECS) is 75% effective for the remission of treatment-resistant depression. Like other more common forms of antidepressant treatment such as fluoxetine, ECS has been shown to increase neurogenesis in the hippocampal dentate gyrus of rodent models. Yet the question of how ECS-induced neurogenesis supports improvement of depressive symptoms remains unknown. Here, we show that ECS-induced neurogenesis is necessary to improve depressive-like behavior of mice exposed to chronic corticosterone (Cort)...
March 5, 2024: bioRxiv
https://read.qxmd.com/read/38495618/effects-of-a-humanized-cd47-antibody-and-recombinant-sirp%C3%AE-proteins-on-triple-negative-breast-carcinoma-stem-cells
#23
JOURNAL ARTICLE
Sukhbir Kaur, Bianca Reginauld, Sam Razjooyan, Trung Phi, Satya P Singh, Thomas J Meyer, Margaret C Cam, David D Roberts
Signal regulatory protein-α (SIRPα, SHPS-1, CD172a) expressed on myeloid cells transmits inhibitory signals when it engages its counter-receptor CD47 on an adjacent cell. Elevated CD47 expression on some cancer cells thereby serves as an innate immune checkpoint that limits phagocytic clearance of tumor cells by macrophages and antigen presentation to T cells. Antibodies and recombinant SIRPα constructs that block the CD47-SIRPα interaction on macrophages exhibit anti-tumor activities in mouse models and are in ongoing clinical trials for treating several human cancers...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38494429/development-of-a-search-filter-to-retrieve-reports-of-interrupted-time-series-studies-from-medline-and-pubmed
#24
JOURNAL ARTICLE
Phi-Yen Nguyen, Joanne E McKenzie, Simon L Turner, Matthew J Page, Steve McDonald
BACKGROUND: Interrupted time series (ITS) studies contribute importantly to systematic reviews of population-level interventions. We aimed to develop and validate search filters to retrieve ITS studies in MEDLINE and PubMed. METHODS: A total of 1017 known ITS studies (published 2013-2017) were analysed using text mining to generate candidate terms. A control set of 1398 time-series studies were used to select differentiating terms. Various combinations of candidate terms were iteratively tested to generate three search filters...
March 17, 2024: Research Synthesis Methods
https://read.qxmd.com/read/38492137/assessment-of-microplastic-contamination-in-some-commercial-fishes-of-the-southern-caspian-sea-and-its-potential-risks
#25
JOURNAL ARTICLE
Mohammad Gholizadeh, Tahereh Bagheri, Mohammad Harsij, Durali Danabas, Mohammad Zakeri, Mohammad Abdul Momin Siddique
This study examined the occurrence of microplastics (MPs) in the gastrointestinal tract (GIT) of 384 fishes classified into four species from 11 sites in 2022 from the southern part of the Caspian Sea. GITs of fishes were collected and digested in H2 O2 and KOH at 45 °C for 72 h. After filtration, extracted MPs were observed under a stereomicroscope, and selected MP particles were identified using FTIR. Presence of MPs was 68.98% in the GIT of the investigated fish. The mean abundance of MPs was 5...
March 16, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38490196/type-i-interferon-responsive-microglia-shape-cortical-development-and-behavior
#26
JOURNAL ARTICLE
Caroline C Escoubas, Leah C Dorman, Phi T Nguyen, Christian Lagares-Linares, Haruna Nakajo, Sarah R Anderson, Jerika J Barron, Sarah D Wade, Beatriz Cuevas, Ilia D Vainchtein, Nicholas J Silva, Ricardo Guajardo, Yinghong Xiao, Peter V Lidsky, Ellen Y Wang, Brianna M Rivera, Sunrae E Taloma, Dong Kyu Kim, Elizaveta Kaminskaya, Hiromi Nakao-Inoue, Bjoern Schwer, Thomas D Arnold, Ari B Molofsky, Carlo Condello, Raul Andino, Tomasz J Nowakowski, Anna V Molofsky
Microglia are brain-resident macrophages that shape neural circuit development and are implicated in neurodevelopmental diseases. Multiple microglial transcriptional states have been defined, but their functional significance is unclear. Here, we identify a type I interferon (IFN-I)-responsive microglial state in the developing somatosensory cortex (postnatal day 5) that is actively engulfing whole neurons. This population expands during cortical remodeling induced by partial whisker deprivation. Global or microglial-specific loss of the IFN-I receptor resulted in microglia with phagolysosomal dysfunction and an accumulation of neurons with nuclear DNA damage...
March 8, 2024: Cell
https://read.qxmd.com/read/38489820/neurocognitive-outcomes-and-associated-clinical-factors-5-years-after-surgery-in-children-with-craniosynostosis
#27
JOURNAL ARTICLE
Joo Whan Kim, Kyung Hyun Kim, Ji Hoon Phi, Ji Yeoun Lee, Eun Jung Koh, Byung Jun Kim, Jee Hyeok Chung, Min-Sup Shin, Seung-Ki Kim
OBJECTIVE: Craniosynostosis involves early closure of one or more sutures, which is known to limit normal cranium growth and interfere with normal brain development. Various surgical methods are used, ranging from minimally invasive strip craniectomy to more extensive whole-vault cranioplasty. This study aimed to evaluate neurocognitive outcomes 5 years after surgical treatment in children with craniosynostosis and to evaluate relevant clinical factors. METHODS: After exclusion of genetically confirmed syndromic craniosynostosis patients, a retrospective review was conducted on 112 nonsyndromic craniosynostosis patients who underwent surgical treatment and follow-up neurocognitive assessment...
March 15, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38489577/feasibility-and-efficacy-of-indocyanine-green-in-monitoring-systemic-drug-leakage-during-isolated-limb-perfusion-for-recurrent-melanoma-of-extremity
#28
JOURNAL ARTICLE
Sri Siddharth Nekkanti, Syed Nusrath, Rajesh Jarang, Basanth Kumar Rayani, Yerramshetty Vamshi Krishna, Kalidindi Venkata Vijaya Narsimha Raju
Melanoma is known for its high metastatic potential and aggressive growth. Recurrence is common post-surgery, sometimes leading to unresectable disease. Locally recurrent unresectable melanoma of extremity has been treated with high-dose anticancer chemotherapy via isolated limb perfusion (ILP) to improve local efficacy of drug and salvage limbs. Standard ILP monitoring uses radiolabeled dyes, requiring specialized personnel and involving radiation exposure. In this case, we used indocyanine green (ICG) to track systemic drug leakage during ILP...
March 15, 2024: Melanoma Research
https://read.qxmd.com/read/38488914/residue-behavior-and-consumer-risk-assessment-of-spirotetramat-and-chlorpyrifos-on-cabbage-heads-and-cropped-soil
#29
JOURNAL ARTICLE
Pankaj Sharma Istatu, Jatiender Kumar Dubey, Sapna Katna, Ajay Sharma, Sakshi Sharma, Deepika Shandil, Nisha Devi, Arvind Kumar, Shubhra Singh, Nimisha Thakur
A field experiment following good agricultural practices was laid out to study the dissipation of spirotetramat (90 g a.i. ha-1 and 180 g a.i. ha-1 ) and chlorpyrifos (400 g a.i. ha-1 and 800 g a.i. ha-1 ) on cabbage heads and soil. Samples were processed using quick, easy, cheap, effective, rugged, and safe (QuEChERS) method for residue estimation of spirotetramat and chlorpyrifos, which were further detected using HPLC-PDA and GC-FPD respectively. The residues of spirotetramat on cabbage heads reached below detection limit (BDL) (< 0...
March 15, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38480574/-descriptive-review-of-patents-in-healthcare-and-nursing-based-on-network-analysis
#30
REVIEW
Misun Jeon, Nayung Youn, Sanghee Kim
PURPOSE: The significance of the healthcare industry has grown exponentially in recent years due to the impact of the fourth industrial revolution and the ongoing pandemic. Accordingly, this study aimed to examine domestic healthcare-related patents comprehensively. Big data analysis was used to present the trend and status of patents filed in nursing. METHODS: The descriptive review was conducted based on Grant and Booth's descriptive review framework. Patents related to nursing was searched in the Korea Intellectual Property Rights Information Service between January 2016 to December 2020...
February 2024: Journal of Korean Academy of Nursing
https://read.qxmd.com/read/38480077/different-diagnostic-strategies-combining-prostate-health-index-and-magnetic-resonance-imaging-for-predicting-prostate-cancer-a-multicentre-study
#31
JOURNAL ARTICLE
Meikai Zhu, Qiang Fu, Yunjiang Zang, Zhiqiang Shao, Yongheng Zhou, Zhiwen Jiang, Wenfu Wang, Benkang Shi, Shouzhen Chen, Yaofeng Zhu
OBJECTIVE: To explore how prostate health index (PHI) and multiparametric magnetic resonance imaging (mpMRI) should be used in concert to improve diagnostic capacity for clinically significant prostate cancers (CsCaP) in patients with prostate-specific antigen (PSA) between 4 and 20 ng/ml. METHODS: About 426 patients fulfilling the inclusion criteria were included in this study. Univariable and multivariable logistic analyses were performed to analyze the association between the clinical indicators and CaP/CsCaP...
March 12, 2024: Urologic Oncology
https://read.qxmd.com/read/38479416/-clinical-courses-and-costs-for-hospitalizations-of-potentially-immunocompromised-covid-19-patients-in-germany
#32
JOURNAL ARTICLE
Dennis Häckl, Marc Pignot, Phi Long Dang, Victoria Lauenroth, Fungwe Jah, Clemens-Martin Wendtner
BACKGROUND:  Patients at increased risk of inadequate immune response to COVID-19 vaccinations due to their underlying disease or therapy are potentially vulnerable to severe COVID-19 courses. The aim is to assess the population size, clinical courses and hospitalization costs of these patients in Germany. METHODS:  This retrospective cohort study is based on extrapolations of a representative sample of statutory health insurance (SHI) claims data from 2020...
March 2024: Deutsche Medizinische Wochenschrift
https://read.qxmd.com/read/38478041/incorporating-phi-in-decision-making-external-validation-of-the-rotterdam-risk-calculators-for-detection-of-prostate-cancer
#33
MULTICENTER STUDY
Leire Rius Bilbao, Urko Aguirre Larracoechea, Carmen Valladares Gomez, Sebastiaan Remmers, Carmen Mar Medina
PURPOSE: External validation of existing risk calculators (RC) to assess the individualized risk of detecting prostate cancer (PCa) in prostate biopsies is needed to determine their clinical usefulness. The objective was to externally validate the Rotterdam Prostate Cancer RCs 3 and 4 (RPCRC-3/4) and that incorporating PHI (RPCRC-PHI) in a contemporary Spanish cohort. METHODS: Multicenter prospective study that included patients suspicious of harboring PCa. Men who attended the urology consultation were tested for PHI before prostate biopsy...
March 13, 2024: World Journal of Urology
https://read.qxmd.com/read/38473077/genomic-and-proteomic-analyses-of-extracellular-products-reveal-major-virulence-factors-likely-accounting-for-differences-in-pathogenicity-to-bivalves-between-vibrio-mediterranei-strains
#34
JOURNAL ARTICLE
Congling Fan, Wenfang Dai, Haiyan Zhang, Sheng Liu, Zhihua Lin, Qinggang Xue
Vibrio mediterranei , a bacterial pathogen of bivalves, has exhibited strain-dependent virulence. The mechanisms behind the variations in bivalve pathogenicity between V. mediterranei strains have remained unclear. However, a preliminary analysis of the extracellular product (ECP) proteomes has revealed differences in protein compositions between low- and high-virulence strains; in addition to 1265 shared proteins, 127 proteins have been identified to be specific to one low-virulence strain and 95 proteins to be specific to two high-virulence strains...
February 22, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38469577/the-retrospective-analysis-of-trigen-intertan-nail-in-the-treatment-of-unstable-intertrochanteric-femoral-fractures-at-hospital-for-traumatology-and-orthopaedics
#35
JOURNAL ARTICLE
Tuan Anh Nguyen, Anh Quoc Hoang, Tam Ngoc Phan, Truong Xuan Nguyen, Nam Ngoc Nguyen, Phi Duong Nguyễn
BACKGROUND: Intertrochanteric fractures are highly prevalent among the elderly population, with approximately 90% occurring in individuals aged over 65. These geriatric fractures are associated with elevated mortality rates and significant functional impairment. Common treatment modalities for unstable intertrochanteric fractures include proximal femoral nail antirotation (PFNA) and the InterTan nail (IT). PFNA and IT are frequently employed due to their lower failure rates and favorable biomechanical properties, resulting in positive clinical outcomes for the management of unstable intertrochanteric fractures...
2024: Orthopedic Reviews
https://read.qxmd.com/read/38469576/microsurgical-reimplantation-outcomes-for-complete-and-incomplete-amputations-of-distal-phalanges-of-fingers
#36
JOURNAL ARTICLE
Tuong Trong Mai, Thach Ngoc Nguyen, Thang Dzu Le Phan, Khanh Hoa Vo, Phi Duong Nguyen
INTRODUCTION: The intricate endeavor of replanting the distal phalanx of the finger remains a persistent challenge. In the pursuit of addressing this concern, microsurgical replantation procedures have been systematically examined for distal phalanx injuries encircling the distal interphalangeal (DIP) joint, conducted at the Orthopaedic Hospital situated in Ho Chi Minh City. MATERIALS AND METHODS: This investigation encompassed a cohort of 31 patients, comprising individuals with 17 instances of complete and 21 instances of incomplete amputations of the distal phalanges...
2024: Orthopedic Reviews
https://read.qxmd.com/read/38467085/microplastics-in-retail-shellfish-from-a-seafood-market-in-eastern-thailand-occurrence-and-risks-to-human-food-safety
#37
JOURNAL ARTICLE
Parnuch Hongsawat, Waleerat Thinjong, Bopit Chouychai, Patiparn Punyapalakul, Panida Prarat
This study aimed to investigate the presence of microplastics in three economically essential shellfish species: green mussels, cockles and spotted babylon. The average abundance of microplastics ranged from 2.41 to 2.84 particles/g wet weight. The predominant shape was fiber, with colors ranging from black-grey to transparent. The size of the microplastics discovered was <1.0 mm. Polystyrene and polyethylene were the most detected types in mussels and cockles, while linen was the predominant type in spotted babylon...
March 10, 2024: Marine Pollution Bulletin
https://read.qxmd.com/read/38465716/cryostripping-versus-conventional-safenectomy-in-chronic-venous-disease-treatment-a-single-center-retrospective-cohort-study
#38
JOURNAL ARTICLE
Sergiu-Ciprian Matei, Daniela Radu-Teodorescu, Marius Sorin Murariu, Cristina Ștefania Dumitru, Sorin Olariu
This study presents a comparative analysis of cryostripping to conventional saphenectomy. Materials and Methods: The study included 2191 patients admitted in the Phlebology Department, 1st Surgical Department, Emergency County Hospital Timisoara, between September 2013 and April 2023, between September 2013 and April 2023, who underwent saphenectomy by cryostripping (1327 patients) or conventionally (864 patients). We compared the duration and costs of the procedure, hospitalization period, post-operative results, method feasibility, as well as the technical advantages of cryostripping compared to conventional surgery...
February 2024: Chirurgia
https://read.qxmd.com/read/38464711/evaluation-of-the-existence-of-post-covid-19-tachycardia-in-a-community-healthcare-system
#39
JOURNAL ARTICLE
Jifeng Wang, Dhaval Patel, Shane Robinson, Ania Rynarzewska, Oluseyi Abidoye
BACKGROUND: Post-coronavirus disease 2019 (COVID-19) syndrome derives from lingering symptoms after an acute COVID-19 infection. Palpitation was one of the most common symptoms of post-COVID-19 syndrome that correlated with objective data such as persisting sinus tachycardia; but to our best knowledge, there is a scarcity of research regarding the association of COVID-19 and sinus tachycardia in the post-acute setting. Therefore, the purpose was to identify if there is an association between COVID-19 infection and sinus tachycardia in the post-acute phase, namely post-COVID-19 tachycardia (PCT) other than inappropriate sinus tachycardia (IST) and postural orthostatic tachycardia syndrome (POTS)...
February 2024: Cardiology Research
https://read.qxmd.com/read/38461753/role-of-glutathione-s-transferases-in-the-mode-of-action-of-herbicides-that-inhibit-amino-acid-synthesis-in-amaranthus-palmeri
#40
JOURNAL ARTICLE
Mikel V Eceiza, Clara Jimenez-Martinez, Miriam Gil-Monreal, María Barco-Antoñanzas, Maria Font-Farre, Michiel Huybrechts, RenierA L van der Hoorn, Ann Cuypers, Mercedes Royuela, Ana Zabalza
Acetolactate synthase inhibitors (ALS inhibitors) and glyphosate are two classes of herbicides that act by inhibiting an enzyme in the biosynthetic pathway of branched-chain or aromatic amino acids, respectively. Besides amino acid synthesis inhibition, both herbicides trigger similar physiological effects in plants. The main aim of this study was to evaluate the role of glutathione metabolism, with special emphasis on glutathione S-transferases (GSTs), in the mode of action of glyphosate and ALS inhibitors in Amaranthus palmeri...
March 5, 2024: Plant Physiology and Biochemistry: PPB
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