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https://www.readbyqxmd.com/read/29332023/autonomic-response-testing-compared-with-immunoglobulin-e-allergy-panel-test-results-preliminary-report
#1
Autumn Frandsen, Mark McClure, Myung Kyu Chung, Patrick J LaRiccia
Context • Chronically ill patients who have failed standard medical assessment and therapies are often assessed by integrative medical providers for atypical manifestations of allergies as the possible source or contributing factor(s) to their condition. Skin testing and immunoglobulin E (IgE) allergy panels increase the cost of care in these patients. Objective • The objective of this study was to determine the accuracy of autonomic response testing (ART) as compared with IgE allergy panel blood tests...
January 15, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29324258/il-18-and-stem-cell-factor-affect-hematopoietic-progenitor-cells-in-hiv-infected-patients-treated-during-primary-hiv-infection
#2
Veronica Bordoni, Domenico Viola, Alessandra Sacchi, Carmela Pinnetti, Rita Casetti, Eleonora Cimini, Nicola Tumino, Andrea Antinori, Adriana Ammassari, Chiara Agrati
The impact of early antiretroviral therapy (ART) during Primary HIV Infection (PHI) on the hematopoietic progenitor cells (HPCs) homeostasis is not available. This study aimed to characterize HPCs and their relationship with cytokines regulating progenitors function in ART-treated patients with PHI. We enrolled HIV infected patients treated with ART during PHI. Circulating HPCs, Lymphoid-HPCs (L-HPCs) frequency and plasmatic concentrations of IL-7, IL-18 and Stem Cell Factor (SCF) were analysed at baseline and after 6 months of therapy...
January 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29318675/toward-an-aqueous-solar-battery-direct-electrochemical-storage-of-solar-energy-in-carbon-nitrides
#3
Filip Podjaski, Julia Kröger, Bettina V Lotsch
Graphitic carbon nitrides have emerged as an earth-abundant family of polymeric materials for solar energy conversion. Herein, a 2D cyanamide-functionalized polyheptazine imide (NCN-PHI) is reported, which for the first time enables the synergistic coupling of two key functions of energy conversion within one single material: light harvesting and electrical energy storage. Photo-electrochemical measurements in aqueous electrolytes reveal the underlying mechanism of this "solar battery" material: the charge storage in NCN-PHI is based on the photoreduction of the carbon nitride backbone and charge compensation is realized by adsorption of alkali metal ions within the NCN-PHI layers and at the solution interface...
January 10, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29318380/dissipation-kinetics-and-risk-assessment-of-chlorfenapyr-on-tomato-and-cabbage
#4
Sandip Patra, Pritam Ganguly, Suhrid Ranjan Barik, Arunava Samanta
A field experiment was conducted over two seasons to evaluate the dissipation kinetics and assess the risks of chlorfenapyr in tomato and cabbage following foliar application of chlorfenapyr 10% SC at 100 and 200 g a.i. ha-1. Samples of tomato, cabbage, and soil were analyzed and quantified by gas chromatography-electron capture detector (GC-ECD). The limit of detection (LOD) and limit of quantification (LOQ) of chlorfenapyr were found to be 0.01 and 0.03 mg kg-1, respectively, in tomato, cabbage, and soil...
January 9, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29317314/phi-in-physiology-psychology-and-biomechanics-the-golden-ratio-between-myth-and-science
#5
REVIEW
Marco Iosa, Giovanni Morone, Stefano Paolucci
In recent years, there has been a renewed interest in the use of the so-called golden ratio (Phi, ϕ), an irrational number with fractal properties, used in artworks since V century BC. and now for modelling complex biological structures and functions. This number, in fact, recursively pops-up in human history, from Ancient Greeks to Renaissance, and to contemporary scientific studies. Nevertheless, recent scientific results often fall between two extremes: those of a priori sceptic researchers accusing the artificial emergence of ϕ in many studies, and those of researchers that find a mystic meaning in the presence of ϕ in human physiology...
January 6, 2018: Bio Systems
https://www.readbyqxmd.com/read/29315949/transcriptome-based-analyses-of-phosphite-mediated-suppression-of-rust-pathogens-puccinia-emaculata-and-phakopsora-pachyrhizi-and-functional-characterization-of-selected-fungal-target-genes
#6
Upinder S Gill, Liang Sun, Sachin Rustgi, Yuhong Tang, Diter von Wettstein, Kirankumar S Mysore
Phosphite (Phi) is commercially used to manage diseases mainly caused by Oomycetes, primarily due to its low-cost compared to other fungicides, and persistent control of oomycetous pathogens. We explored the use of Phi in controlling fungal pathogens Puccinia emaculata and Phakopsora pachyrhizi the causal agents of the switchgrass rust and the Asian soybean rust, respectively. Phi primes host defenses and efficiently inhibits growth of P. emaculata, P. pachyrhizi, and several other fungal pathogens tested. To understand the Phi-mediated effects, a detailed molecular analysis was undertaken in both the host and the pathogen...
January 6, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29313044/a-mild-method-for-synthesizing-carboxylic-acids-by-oxidation-of-aldoximes-using-hypervalent-iodine-reagents
#7
Akira Nakamura, Hodaka Kanou, Junki Tanaka, Akira Imamiya, Tomohiro Maegawa, Yasuyoshi Miki
A mild oxidation method for the conversion of aldoximes to carboxylic acids was developed mediated by hypervalent iodine reagents. This method covers a wide range of functionalized aldoximes and proceeds under mild conditions, utilizing PhI(OH)OTs as an oxidant.
January 9, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29310716/critical-low-temperature-for-the-survival-of-aedes-aegypti-in-taiwan
#8
Pui-Jen Tsai, Tang-Huang Lin, Hwa-Jen Teng, Hsi-Chyi Yeh
BACKGROUND: Taiwan is geographically located in a region that spans both tropical and subtropical climates (22-25°N and 120-122°E). The Taiwan Centers for Disease Control have found that the ecological habitat of Aedes aegypti appears only south of 23.5°N. Low temperatures may contribute to this particular habitat distribution of Ae. aegypti under the influence of the East Asian winter monsoon. However, the threshold condition related to critically low temperatures remains unclear because of the lack of large-scale spatial studies...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29304547/soft-hard-acid-base-controlled-oxidative-n-selective-arylation-of-sulfonanilides-via-a-nitrenium-ion
#9
Saikat Maiti, Prasenjit Mal
In iodine (III)-catalyzed, dehydrogenative arylations of sulfonanilides, the functionalization of C-C bonds is preferred over the functionalization of C-N bonds. Herein, an unprecedented N-selective arylation of sulfonanilides using soft-hard acid-base (SHAB) control by a nitrenium ion over a carbenium ion is reported. Treatment of sulfonanilides with iodine (III) led to the formation of nitrenium ions (soft), which preferentially react with biphenyls (soft) over bimesityl (hard) to generate C-N bonds. The iodine (III) was generated in situ by using PhI and mCPBA at room temperature...
January 5, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29299923/hairpin-contained-i-motif-based-fluorescent-ratiometric-probe-for-high-resolution-and-sensitive-response-of-small-ph-variations
#10
Wenjie Ma, Lv'an Yan, Xiaoxiao He, Taiping Qing, Yanli Lei, Zhenzhen Qiao, Dinggeng He, Kaihang Huang, Kemin Wang
Intracellular pH (pHi) is an important parameter associated with cellular behaviors and pathological conditions. Sensing pHi and monitoring its changes are essential but challenging due to the lack of high-sensitive probes. Herein, a ratiometric fluorescent probe with ultra pH-sensitivity is developed based on hairpin-contained i-motif strand (I-strand, labeled with Rhodamine Green and BHQ2 at two termini) and complementary strand (C-strand, labeled with Rhodamine Red at its 5'-end). At neutral pH, both I-strand and C-strand hybridize into a rigid duplex (I-C), which holds the Rhodamine Red and the BHQ2 in close proximity...
January 4, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29299874/in-vitro-production-of-cartilage-tissue-from-rabbit-bone-marrow-derived-mesenchymal-stem-cells-and-polycaprolactone-scaffold
#11
Thuy Thi-Thanh Dao, Ngoc Bich Vu, Liem Hieu Pham, Long Van Gia, Ha Thi-Ngan Le, Lan Thi Phi, Khanh Hong-Thien Bui, Phuong Thi-Bich Le, Phuc Van Pham
In vitro production of tissues or tissue engineering is a promising approach to produce artificial tissues for regenerative medicine. There are at least three important components of tissue engineering, including stem cells, scaffolds and growth factors. This study aimed to produce cartilage tissues in vitro from culture and chondrogenic differentiation of rabbit bone marrow-derived mesenchymal stem cells (BMMSCs), induced by chondrogenesis medium, on biodegradable polycaprolactone (PCL) scaffolds. BMMSCs were isolated from rabbit bone marrow according to the standard protocol...
January 4, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29288450/systems-biology-modeling-to-study-pathogen-host-interactions
#12
Müberra Fatma Cesur, Saliha Durmuş
Pathogen-host interactions (PHIs) underlie the process of infection. The systems biology view of the whole PHI system is superior to the investigation of the pathogen or host separately in understanding the infection mechanisms. Especially, the identification of host-oriented drug targets for the next-generation anti-infection therapeutics requires the properties of the host factors targeted by pathogens. Here, we provide an outline of computational analysis of PHI networks, focusing on the properties of the pathogen-targeted host proteins...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29282434/the-inspired-sinewave-technique-a-comparison-study-with-body-plethysmography-in-healthy-volunteers
#13
Phi Anh Phan, Cathy Zhang, Daniel Geer, Federico Formenti, Clive E W Hahn, Andrew D Farmery
The inspired sinewave technique is a noninvasive method to measure airway dead space, functional residual capacity, pulmonary blood flow, and lung inhomogeneity simultaneously. The purpose of this paper was to assess the repeatability and accuracy of the current device prototype in measuring functional residual capacity, and also participant comfort when using such a device. To assess within-session repeatability, six sinewave measurements were taken over two-hour period in 17 healthy volunteers. To assess day-to-day repeatability, measurements were taken over 16 days in 3 volunteers...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29261684/neural-mechanisms-underlying-sensitivity-to-reverse-phi-motion-in-the-fly
#14
Aljoscha Leonhardt, Matthias Meier, Etienne Serbe, Hubert Eichner, Alexander Borst
Optical illusions provide powerful tools for mapping the algorithms and circuits that underlie visual processing, revealing structure through atypical function. Of particular note in the study of motion detection has been the reverse-phi illusion. When contrast reversals accompany discrete movement, detected direction tends to invert. This occurs across a wide range of organisms, spanning humans and invertebrates. Here, we map an algorithmic account of the phenomenon onto neural circuitry in the fruit fly Drosophila melanogaster...
2017: PloS One
https://www.readbyqxmd.com/read/29250024/clinical-predictors-of-progressive-hemorrhagic-injury-in-children-with-mild-traumatic-brain-injury
#15
Guangfu Di, Hua Liu, Xiaochun Jiang, Yi Dai, Sansong Chen, Zhichun Wang, Hongyi Liu
Objective: Traumatic brain injury (TBI) occurs commonly in children. Repeat computed tomography (CT) follow up of TBI patients is often scheduled to identify progressive hemorrhagic injury (PHI). However, the utility of repeated CT scans, especially in children with mild TBI [Glasgow Coma Scale (GCS) scores of 13-15], has been debated. The purposes of the present study were to identify clinical predictors of PHI in children with mild TBI and to clarify relevant clinical factors via radiological examination...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29242214/expressed-gene-fusions-as-frequent-drivers-of-poor-outcomes-in-hormone-receptor-positive-breast-cancer
#16
Karina J Matissek, Maristela L Onozato, Sheng Sun, Zongli Zheng, Andrew Schultz, Jesse Lee, Kristofer Patel, Piiha-Lotta Jerevall, Srinivas V Saladi, Allison MacLeay, Mehrad Tavallai, Tanja Badovinac-Crnjevic, Carlos Barrios, Nuran Beşe, Arlene Chan, Yanin Chavarri-Guerra, Marcio Debiasi, Elif Demirdogen, Unal Egeli, Sehsuvar Gökgöz, Henry Gomez, Pedro Liedke, Ismet Tasdelen, Sahsine Tolunay, Gustavo Werutsky, Jessica St Louis, Nora Horick, Dianne M Finkelstein, Long Phi Le, Aditya Bardia, Paul E Goss, Dennis C Sgroi, A John Iafrate, Leif W Ellisen
We sought to uncover novel genetic drivers of hormone-receptor positive (HR+) breast cancer, employing a targeted next-generation sequencing approach for detecting expressed gene rearrangements without prior knowledge of the fusion partners. We identified intergenic fusions involving driver genes including PIK3CA, AKT3, RAF1 and ESR1 in 14% (24/173) of unselected patients with advanced HR+ breast cancer. Fluorescence in situ hybridization (FISH) confirmed the corresponding chromosomal rearrangements in both primary and metastatic tumors...
December 14, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29232037/incorporating-prostate-health-index-density-mri-and-prior-negative-biopsy-status-to-improve-the-detection-of-clinically-significant-prostate-cancer
#17
Sasha C Druskin, Jeffrey J Tosoian, Allen Young, Sarah Collica, Arnav Srivastava, Kamyar Ghabili, Katarzyna J Macura, Ballentine H Carter, Alan W Partin, Lori J Sokoll, Ashley E Ross, Christian P Pavlovich
OBJECTIVES: To determine the performance of Prostate Health Index (PHI) density (PHID) combined with MRI and prior negative biopsy (PNB) status for the diagnosis of clinically-significant prostate cancer (PCa). PATIENTS & METHODS: Patients without a prior diagnosis of PCa, with elevated PSA and a normal digital rectal exam who had PHI testing prospectively prior to prostate biopsy were included. PHID was calculated retrospectively using prostate volume derived from transrectal ultrasound at biopsy...
December 12, 2017: BJU International
https://www.readbyqxmd.com/read/29219825/ending-the-epidemic-critical-role-of-primary-hiv-infection
#18
H A B Prins, A Verbon, C A B Boucher, C Rokx
Early identification and immediate treatment of individuals newly infected with HIV is important for two reasons: it benefits the long-term health of the infected patient, and it reduces onward HIV transmission. Primary HIV infection (PHI) reflects the period following HIV acquisition during which viraemia bursts until the establishment of a stable plasma HIV-RNA level approximately six months post infection. During this period, patients are particularly contagious and are often unaware of the infection. As a consequence, PHI disproportionally affects onward transmission...
October 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29219755/mitochondrial-abnormalities-related-to-the-dysfunction-of-circulating-endothelial-colony-forming-cells-in-moyamoya-disease
#19
Jung Won Choi, Sung Min Son, Inhee Mook-Jung, Youn Joo Moon, Ji Yeoun Lee, Kyu-Chang Wang, Hyun-Seung Kang, Ji Hoon Phi, Seung Ah Choi, Sangjoon Chong, Jayoung Byun, Seung-Ki Kim
OBJECTIVE Moyamoya disease (MMD) is a unique cerebrovascular disorder characterized by the progressive occlusion of the bilateral internal carotid arteries. Endothelial colony-forming cells (ECFCs), previously termed "endothelial progenitor cells," play an important role in the pathogenesis of MMD. In this study, the authors performed morphological and functional studies of the mitochondria of ECFCs from patients with MMD to present new insights into the pathogenesis of the disease. METHODS The morphology of ECFCs from 5 MMD patients and 5 healthy controls was examined under both a transmission electron microscope and a confocal laser scanning microscope...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29213105/preoperative-prostate-health-index-predicts-poor-pathologic-outcomes-of-radical-prostatectomy-in-patients-with-biopsy-detected-low-risk-patients-prostate-cancer-results-from-a-chinese-prospective-cohort
#20
Bo Tang, Cheng-Tao Han, Xiao-Lin Lu, Fang-Ning Wan, Cui-Zhu Zhang, Yao Zhu, Ding-Wei Ye
OBJECTIVE: To determine the performance of the prostate health index (PHI) in predicting pathologic outcomes of radical prostatectomy (RP) in Chinese patients with low-risk prostate cancer (PCa). METHODS: Of all consecutive patients who underwent RP in one tertiary center from September 2013 to January 2017, we prospectively examined the data of 140 patients with low-risk PCa based on the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria...
December 6, 2017: Prostate Cancer and Prostatic Diseases
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