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https://www.readbyqxmd.com/read/29779925/the-application-of-p2psa-and-prostate-health-index-in-prostate-cancer-detection-a-prospective-cohort-in-a-tertiary-medical-center
#1
Yung-Ting Cheng, Chih-Hung Chiang, Yeong-Shiau Pu, Shih Ping Liu, Yu-Chuang Lu, Yi-Kai Chang, Hong-Chiang Chang, Kuo-How Huang, Yuan-Ju Lee, Po-Ming Chow, Shih-Chun Hung, Chao-Yuan Huang
BACKGROUND/PURPOSE: Prostate specific antigen (PSA) with low specificity that causes unnecessary prostate biopsies increases clinical morbidities, psychological stress, and medical expenses. We aimed to test the accuracy and cutoff value of Prostate Health Index (PHI) in men for prostate cancer detection. METHODS: We prospectively enrolled 213 men who underwent prostate biopsy with PSA≦10 ng/ml or abnormal findings on digital rectal examination. Total PSA (tPSA), free PSA (fPSA) and p2PSA levels were measured by serum samples before prostate biopsy...
May 17, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29779716/clinical-3d-printing-a-protected-health-information-phi-and-compliance-perspective
#2
Henry Feldman, Parisa Kamali, Samuel J Lin, John D Halamka
Advanced manufacturing techniques such as 3-dimensional (3D) printing, while mature in other industries, are starting to become more commonplace in clinical care. Clinicians are producing physical objects based on patient clinical data for use in planning care and educating patients, all of which should be managed like any other healthcare system data, except it exists in the "real" world. There are currently no provisions in the Health Insurance Portability and Accountability Act (HIPAA) either in its original 1996 form or in more recent updates that address the nature of physical representations of clinical data...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29777353/intestinal-histopathological-changes-in-a-porcine-model-of-pneumoperitoneum-induced-intra-abdominal-hypertension
#3
Ester Párraga Ros, Laura Correa-Martín, Francisco M Sánchez-Margallo, Irma Eugenia Candanosa-Aranda, Manu L N G Malbrain, Robert Wise, Rafael Latorre, Octavio López Albors, Gregorio Castellanos
BACKGROUND: Low splanchnic perfusion is an immediate effect of pneumoperitoneum-induced intra-abdominal hypertension (IAH). Anatomical structure results in the intestinal mucosa being the area most sensitive to hypoperfusion. The relationship between intestinal injury and clinical parameters of tissue perfusion [abdominal perfusion pressure (APP), gastric intramucosal pH (pHi ) and lactic acid (Lc)] has not been previously studied. This study aimed to monitorize intestinal pathogenesis through sequential ileal biopsies and to measure APP, pHi , and Lc levels at different pneumoperitoneum-induced intra-abdominal pressures (20, 30, and 40 mmHg) to evaluate the potential relationships between them...
May 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29775047/probing-cancer-cells-through-intracellular-aggregation-induced-emission-kinetic-rate-of-copper-nanoclusters
#4
Anushree Dutta, Upashi Goswami, Arun Chattopadhyay
pH responsive luminescent copper nanoclusters (Cu NCs) with aggregation induced emission (AIE) characteristics have been synthesized. Upon internalization into living cells, the NCs displayed cellular pH environment dependent luminescence change with orange-red emission at pHi 4.5 while bright green emission was observed over time at pHi 7.4, through their AIE attributes. Further, the intracellular AIE kinetics of the NC probe was measured in MCF-7 cells and compared with HEK-293 cells. Intriguingly, intracellular rate constant value derived for AIE kinetics in MCF-7 cells was found 3-fold higher than that in HEK-293 cell lines, whereas the value was 2-fold higher than that observed in the aqueous medium...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29770321/developing-workforce-capacity-in-public-health-informatics-core-competencies-and-curriculum-design
#5
Douglas R Wholey, Martin LaVenture, Sripriya Rajamani, Rob Kreiger, Craig Hedberg, Cynthia Kenyon
We describe a master's level public health informatics (PHI) curriculum to support workforce development. Public health decision-making requires intensive information management to organize responses to health threats and develop effective health education and promotion. PHI competencies prepare the public health workforce to design and implement these information systems. The objective for a Master's and Certificate in PHI is to prepare public health informaticians with the competencies to work collaboratively with colleagues in public health and other health professions to design and develop information systems that support population health improvement...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29768119/exploratory-analysis-of-brigatinib-activity-in-patients-with-anaplastic-lymphoma-kinase-positive-non-small-cell-lung-cancer-and-brain-metastases-in-two-clinical-trials
#6
D Ross Camidge, Dong-Wan Kim, Marcello Tiseo, Corey J Langer, Myung-Ju Ahn, Alice T Shaw, Rudolf M Huber, Maximilian J Hochmair, Dae Ho Lee, Lyudmila A Bazhenova, Kathryn A Gold, Sai-Hong Ignatius Ou, Howard L West, William Reichmann, Jeff Haney, Tim Clackson, David Kerstein, Scott N Gettinger
Purpose In patients with crizotinib-treated, anaplastic lymphoma kinase gene ( ALK)-rearranged non-small-cell lung cancer (ALK-positive NSCLC), initial disease progression often occurs in the CNS. We evaluated brigatinib, a next-generation ALK inhibitor, in patients with ALK-positive NSCLC with brain metastases. Patients and Methods Patients with ALK-positive NSCLC received brigatinib (90 to 240 mg total daily) in a phase I/II trial (phI/II; ClinicalTrials.gov identifier: NCT01449461) and in the subsequent randomized phase II trial ALTA (ALK in Lung Cancer Trial of AP26113; ClinicalTrials...
May 16, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29764946/comparative-genomics-reveals-the-core-gene-toolbox-for-the-fungus-insect-symbiosis
#7
Yan Wang, Matt Stata, Wei Wang, Jason E Stajich, Merlin M White, Jean-Marc Moncalvo
Modern genomics has shed light on many entomopathogenic fungi and expanded our knowledge widely; however, little is known about the genomic features of the insect-commensal fungi. Harpellales are obligate commensals living in the digestive tracts of disease-bearing insects (black flies, midges, and mosquitoes). In this study, we produced and annotated whole-genome sequences of nine Harpellales taxa and conducted the first comparative analyses to infer the genomic diversity within the members of the Harpellales...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29760693/treatment-intensification-in-hiv-infected-patients-is-associated-with-reduced-frequencies-of-regulatory-t-cells
#8
Eva M Grützner, Tanja Hoffmann, Eva Wolf, Elke Gersbacher, Ashley Neizert, Renate Stirner, Ramona Pauli, Albrecht Ulmer, Jürgen Brust, Johannes R Bogner, Hans Jaeger, Rika Draenert
In untreated HIV infection, the efficacy of T cell responses decreases over the disease course, resulting in disease progression. The reasons for this development are not completely understood. However, immunosuppressive cells are supposedly crucially involved. Treatment strategies to avoid the induction of these cells preserve immune functions and are therefore the object of intense research efforts. In this study, we assessed the effect of treatment intensification [=5-drug antiretroviral therapy (ART)] on the development of suppressive cell subsets...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29757069/accuracy-of-a-single-measurement-site-for-self-monitoring-of-patients-with-breast-cancer-at-risk-for-lymphedema
#9
Janine T Hidding, Carien H G Beurskens, Marijke T De Vries, Maria W G Nijhuis-van der Sanden, Hanneke W M van Laarhoven, Philip J van der Wees
PURPOSE: Early detection of breast cancer-related lymphedema through simple self-monitoring techniques may lead to early treatment and improved outcomes. METHODS: Prospective study of circumference measurements at four time points before, during, and after adjuvant chemotherapy with docetaxel, doxorubicin, and cyclophosphamide. Volume was calculated using the 10-cm interval circumference measurement method (reference test) and percentage difference between arms, for volume and circumference, was determined...
May 14, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29756391/rho-kinase-and-na-h-exchanger-mediate-endothelin-1-induced-pulmonary-arterial-smooth-muscle-cell-proliferation-and-migration
#10
John C Huetsch, Jasmine Walker, Clark Undem, Julie Lade, Xin Yun, Syeda Baksh, Haiyang Jiang, Ning Lai, Larissa A Shimoda
Excessive production of endothelin-1 (ET-1) has been observed in almost all forms of pulmonary hypertension. ET-1, a highly potent vasoconstrictor, can also potentiate pulmonary arterial smooth muscle cell (PASMC) growth and migration, both of which contribute to the vascular remodeling that occurs during the development of pulmonary hypertension. Increasing evidence indicates that alkalinization of intracellular pH (pHi ), typically due to activation of Na+ /H+ exchange (NHE), is associated with enhanced PASMC proliferation and migration...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29755339/therapeutic-potential-of-a-prolyl-hydroxylase-inhibitor-fg-4592-for-parkinson-s-diseases-in-vitro-and-in-vivo-regulation-of-redox-biology-and-mitochondrial-function
#11
Xuan Li, Xin-Xin Cui, Ya-Jing Chen, Ting-Ting Wu, Huaxi Xu, Huiyong Yin, Yun-Cheng Wu
As the main transcription factor that regulates the cellular responses to hypoxia, Hypoxia-inducible factor-1α (HIF-1α) plays an important role in the pathogenesis of Parkinson's disease (PD). HIF-1α is normally degraded through ubiquitination after hydroxylation by prolyl hydroxylases (PHD). Emerging evidence has suggested that HIF PHD inhibitors (HIF-PHI) may have neuroprotective effects on PD through increasing HIF-1α levels. However, the therapeutic benefit of HIF-PHI for PD remains poorly explored due to the lack of proper clinical compounds and understanding of the underlying molecular mechanisms...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29754812/a-randomized-controlled-trial-to-evaluate-the-safety-and-efficacy-of-cardiac-contractility-modulation
#12
William T Abraham, Karl-Heinz Kuck, Rochelle L Goldsmith, JoAnn Lindenfeld, Vivek Y Reddy, Peter E Carson, Douglas L Mann, Benjamin Saville, Helen Parise, Rodrigo Chan, Phi Wiegn, Jeffrey L Hastings, Andrew J Kaplan, Frank Edelmann, Lars Luthje, Rami Kahwash, Gery F Tomassoni, David D Gutterman, Angela Stagg, Daniel Burkhoff, Gerd Hasenfuß
OBJECTIVES: The authors sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy of the OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) study showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) and quality of life in patients with ejection fractions between 25% and 45%. BACKGROUND: CCM therapy for New York Heart Association (NYHA) functional class III and IV heart failure (HF) patients consists of nonexcitatory electrical signals delivered to the heart during the absolute refractory period...
May 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29754457/cardioprotective-role-of-igf-1-in-the-hypertrophied-myocardium-of-the-spontaneously-hypertensive-rats-a-key-effect-on-nhe-1-activity
#13
Alejandra M Yeves, Juan I Burgos, Andrés J Medina, M Celeste Villa-Abrille, Irene L Ennis
AIM: Myocardial Na+ /H+ exchanger-1 (NHE-1) hyperactivity and oxidative stress are interrelated phenomena playing pivotal roles in the development of pathological cardiac hypertrophy and heart failure. Exercise training is effective to convert pathological into physiological hypertrophy in the spontaneously hypertensive rats (SHR) and IGF-1 -key humoral mediator of exercise training- inhibits myocardial NHE-1, at least in normotensive rats. Therefore, we hypothesize that IGF-1 by hampering NHE-1 hyperactivity and oxidative stress should exert a cardioprotective effect in the SHR...
May 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29749579/in-vivo-detection-of-acute-intracellular-acidification-in-glioblastoma-multiforme-following-a-single-dose-of-cariporide
#14
Mohammed Albatany, Alex Li, Susan Meakin, Robert Bartha
Glioblastoma is an aggressive brain cancer that is very difficult to treat. Clinically, it is important to be able to distinguish aggressive from non-aggressive brain tumors. Previous studies have shown that some drugs can induce a rapid change in intracellular pH that could help to identify aggressive cancer. The sodium proton exchanger (NHE1) plays a significant role in maintaining pH balance in the tumor microenvironment. Cariporide is a sodium proton exchange inhibitor that is well tolerated by humans in cardiac applications...
May 10, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29747134/a-polyclonal-antibody-against-extracellular-loops-1-of-chnhe1-blocks-avian-leukosis-virus-subgroup-j-infection
#15
Wei Meng, Defang Zhou, Chengui Li, Guihua Wang, Libo Huang, Ziqiang Cheng
Avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, induces myelocytomas and other various tumors, leading to great economical losses in poultry industry. It is a great challenge to develop effective preventive methods for ALV-J control due to its antigenic variations in the variable regions of envelope. In present study, we generated a mouse polyclonal antibody targeting the first extracellular loop (ECL1) of chicken Na+ /H+ exchanger isoform 1 (chNHE1), the receptor of ALV-J, to block ALV-J infection in vitro and in vivo...
May 2, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29745226/one-pot-multi-component-mechanosynthesis-of-polysubstituted-trans-2-3-dihydropyrroles-and-pyrroles-from-amines-alkyne-esters-and-chalcones
#16
Hui Xu, Hong-Wei Liu, Kuan Chen, Guan-Wu Wang
An efficient and practical one-pot multi-component reaction of amines with alkyne esters and chalcones promoted by I2/PhI(OAc)2 has been developed under solvent-free ball-milling conditions to afford a variety of polysubstituted trans-2,3-dihydropyrroles in moderate to good yields. The present method features short reaction time, mild reaction conditions, broad substrate scope, and feasibility of large-scale synthesis. Intriguingly, this protocol can also furnish the corresponding synthetically more attractive pyrroles with the addition of an oxidant in a one-pot way...
May 10, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29743301/exotic-properties-of-a-voltage-gated-proton-channel-from-the-snail-helisoma-trivolvis
#17
Sarah Thomas, Vladimir V Cherny, Deri Morgan, Liana R Artinian, Vincent Rehder, Susan M E Smith, Thomas E DeCoursey
Voltage-gated proton channels, HV 1, were first reported in Helix aspersa snail neurons. These H+ channels open very rapidly, two to three orders of magnitude faster than mammalian HV 1. Here we identify an HV 1 gene in the snail Helisoma trivolvis and verify protein level expression by Western blotting of H. trivolvis brain lysate. Expressed in mammalian cells, HtHV 1 currents in most respects resemble those described in other snails, including rapid activation, 476 times faster than hHV 1 (human) at pHo 7, between 50 and 90 mV...
May 9, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29743300/histidine-168-is-crucial-for-%C3%AE-ph-dependent-gating-of-the-human-voltage-gated-proton-channel-hh-v-1
#18
Vladimir V Cherny, Deri Morgan, Sarah Thomas, Susan M E Smith, Thomas E DeCoursey
We recently identified a voltage-gated proton channel gene in the snail Helisoma trivolvis , HtHV 1, and determined its electrophysiological properties. Consistent with early studies of proton currents in snail neurons, HtHV 1 opens rapidly, but it unexpectedly exhibits uniquely defective sensitivity to intracellular pH (pHi ). The H+ conductance ( g H )- V relationship in the voltage-gated proton channel (HV 1) from other species shifts 40 mV when either pHi or pHo (extracellular pH) is changed by 1 unit. This property, called ΔpH-dependent gating, is crucial to the functions of HV 1 in many species and in numerous human tissues...
May 9, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29742889/intraoperative-neurophysiological-monitoring-a-review-of-techniques-used-for-brain-tumor-surgery-in-children
#19
REVIEW
Keewon Kim, Charles Cho, Moon-Suk Bang, Hyung-Ik Shin, Ji-Hoon Phi, Seung-Ki Kim
Intraoperative monitoring (IOM) utilizes electrophysiological techniques as a surrogate test and evaluation of nervous function while a patient is under general anesthesia. They are increasingly used for procedures, both surgical and endovascular, to avoid injury during an operation, examine neurological tissue to guide the surgery, or to test electrophysiological function to allow for more complete resection or corrections. The application of IOM during pediatric brain tumor resections encompasses a unique set of technical issues...
May 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29742886/intracranial-germ-cell-tumor-in-the-molecular-era
#20
REVIEW
Ji Hoon Phi, Kyu-Chang Wang, Seung-Ki Kim
Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection to one sex, and geographic difference in incidence all present enigmas and fascinating challenges. The treatment of iGCT has advanced for germinoma to date; thus, clinical attention has shifted from survival to long-term quality of life. However, for non-germinomatous GCT, current protocols provide only modest improvement and more innovative therapies are needed...
May 2018: Journal of Korean Neurosurgical Society
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