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https://www.readbyqxmd.com/read/29167460/early-vaccination-protects-against-childhood-leukemia-a-systematic-review-and-meta-analysis
#1
Mostafa Ebraheem Morra, Nguyen Dang Kien, Ahmed Elmaraezy, Omar Ayman M Abdelaziz, Ahmed Lotfy Elsayed, Oday Halhouli, Ahmed Mosaad Montasr, Tran Le-Huy Vu, Chau Ho, Amr Sayed Foly, Anh Phan Phi, Wessam Magdy Abdullah, Marina Mikhail, Elizabeth Milne, Kenji Hirayama, Nguyen Tien Huy
Leukemia is the most commonly diagnosed childhood cancer, although its etiology is still largely unknown. Growing evidence supports a role for infection in the etiology of acute lymphocytic leukemia (ALL), and the involvement of the immune system suggests that vaccination may also play a role. However, the findings presented in the published literature are inconsistent. Therefore, we conducted a PRISMA systematic review and meta-analysis. 14 studies were identified and meta-analyzed. Vaccinations studied comprised Bacillus Calmette-Guérin (BCG) vaccine, Triple vaccine, Hepatitis B vaccine (HBV), Polio, Measles, Rubella, Mumps, trivalent MMR vaccine and Haemophilus influenza type B (HiB) vaccine...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167417/loss-of-activity-mutation-in-the-cardiac-chloride-bicarbonate-exchanger-ae3-causes-short-qt-syndrome
#2
Kasper Thorsen, Vibeke S Dam, Kasper Kjaer-Sorensen, Lisbeth N Pedersen, V Arvydas Skeberdis, Jonas Jurevičius, Rimantas Treinys, Ida M B S Petersen, Morten S Nielsen, Claus Oxvig, J Preben Morth, Vladimir V Matchkov, Christian Aalkjær, Henning Bundgaard, Henrik K Jensen
Patients with short QT syndrome (SQTS) may present with syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding cation channels, explain <25% of SQTS cases. Here we identify a missense mutation in the anion exchanger (AE3)-encoding SLC4A3 gene in two unrelated families with SQTS. The mutation causes reduced surface expression of AE3 and reduced membrane bicarbonate transport. Slc4a3 knockdown in zebrafish causes increased cardiac pHi, short QTc, and reduced systolic duration, which is rescued by wildtype but not mutated SLC4A3...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29165718/a-phi-class-glutathione-s-transferase-gene-for-verticillium-wilt-resistance-in-gossypium-arboreum-identified-in-a-genome-wide-association-study
#3
Qian Gong, Zhaoen Yang, Eryong Chen, Gaofei Sun, Shoupu He, Hamama Islam Butt, Chaojun Zhang, Xueyan Zhang, Zuoren Yang, Xiongming Du, Fuguang Li
Verticillium wilt disease is one of the most destructive biotic stresses faced by cotton plants. Here, we performed a genome-wide association study (GWAS) in 215 Chinese Gossypium arboreum accessions inoculated as seedlings with Verticillium dahliae to identify candidate loci involved in wilt resistance. We identified 309 loci that had a significant association with Verticillium wilt resistance and Log (P) values greater than 5.0; the highest signal appeared on Ca3 in a 74 Kb haplotype block. Five genes were also located within this haplotype block...
November 20, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29164279/elemental-concentrations-in-roadside-dust-along-two-national-highways-in-northern-vietnam-and-the-health-risk-implication
#4
Thai Ha Phi, Pham Minh Chinh, Doan Danh Cuong, Luong Thi Mai Ly, Nguyen Van Thinh, Phong K Thai
There is a need to assess the risk of exposure to metals via roadside dust in Vietnam where many people live along the road/highways and are constantly exposed to roadside dust. In this study, we collected dust samples at 55 locations along two major Highways in north-east Vietnam, which passed through different land use areas. Samples were sieved into three different particle sizes and analyzed for concentrations of eight metals using a X-ray fluorescence instrument. The concentrations and environmental indices (EF, I geo) of metals were used to evaluate the degree of pollution in the samples...
November 21, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29158732/what-do-anesthesiologists-know-about-p-values-confidence-intervals-and-correlations-a-pilot-survey
#5
Patrick Schober, Sebastiaan M Bossers, Phi-Vu Dong, Christa Boer, Lothar A Schwarte
Background: Statistical methods form the basis for clinical decision-making in evidence-based anesthesia. Data on the knowledge of anesthesiologists about statistics are lacking. This pilot study aims to provide a first impression of the anesthesiologists' understanding of commonly used concepts in statistics. Methods: A cross-sectional pilot survey was performed at a major international anesthesia conference. The questionnaire consisted of three basic multiple-choice questions on the topics "p value," "confidence interval," and "correlation...
2017: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/29158509/clinical-utility-of-the-prostate-health-index-phi-for-biopsy-decision-management-in-a-large-group-urology-practice-setting
#6
Jay White, B Vittal Shenoy, Ronald F Tutrone, Lawrence I Karsh, Daniel R Saltzstein, William J Harmon, Dennis L Broyles, Tamra E Roddy, Lori R Lofaro, Carly J Paoli, Dwight Denham, Mark A Reynolds
BACKGROUND: Deciding when to biopsy a man with non-suspicious DRE findings and tPSA in the 4-10 ng/ml range can be challenging, because two-thirds of such biopsies are typically found to be benign. The Prostate Health Index (phi) exhibits significantly improved diagnostic accuracy for prostate cancer detection when compared to tPSA and %fPSA, however only one published study to date has investigated its impact on biopsy decisions in clinical practice. METHODS: An IRB approved observational study was conducted at four large urology group practices using a physician reported two-part questionnaire...
November 20, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29158350/cell-fate-decisions-emerging-roles-for-metabolic-signals-and-cell-morphology
#7
REVIEW
Sumitra Tatapudy, Francesca Aloisio, Diane Barber, Todd Nystul
Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. However, recent studies have found that other aspects of cell biology also make important contributions to regulating cell fate decisions. These cues can have a permissive or instructive role and are integrated into the larger network of signaling, functioning both upstream and downstream of developmental signaling pathways...
November 20, 2017: EMBO Reports
https://www.readbyqxmd.com/read/29157201/phylogenetic-and-recombination-analysis-of-the-herpesvirus-genus-varicellovirus
#8
Aaron W Kolb, Andrew C Lewin, Ralph Moeller Trane, Gillian J McLellan, Curtis R Brandt
BACKGROUND: The varicelloviruses comprise a genus within the alphaherpesvirus subfamily, and infect both humans and other mammals. Recently, next-generation sequencing has been used to generate genomic sequences of several members of the Varicellovirus genus. Here, currently available varicellovirus genomic sequences were used for phylogenetic, recombination, and genetic distance analysis. RESULTS: A phylogenetic network including genomic sequences of individual species, was generated and suggested a potential restriction between the ungulate and non-ungulate viruses...
November 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29143921/dichloroacetate-induced-intracellular-acidification-in-glioblastoma-in-vivo-detection-using-aacid-cest-mri-at-9-4%C3%A2-tesla
#9
Mohammed Albatany, Alex Li, Susan Meakin, Robert Bartha
Intracellular pH (pHi) plays an important role in the maintenance of normal cell function, and is maintained within a narrow range by the activity of transporters located at the plasma membrane. Modulation of tumor pHi may influence proliferation, apoptosis, chemotherapy resistance, and thermosensitivity. Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is dependent on cellular pH. Amine and amide concentration-independent detection (AACID) is a recently developed CEST contrast method that is intracellular pH (pHi) weighted...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143542/structure-longitudinal-invariance-and-stability-of-the-child-behavior-checklist-1%C3%A2-5-s-diagnostic-and-statistical-manual-of-mental-disorders-autism-spectrum-disorder-scale-findings-from-generation-r-rotterdam
#10
Leslie A Rescorla, Akhgar Ghassabian, Masha Y Ivanova, Vincent Wv Jaddoe, Frank C Verhulst, Henning Tiemeier
Although the Child Behavior Checklist 1½-5's 12-item Diagnostic and Statistical Manual of Mental Disorders-Autism Spectrum Problems Scale (formerly called Pervasive Developmental Problems scale) has been used in several studies as an autism spectrum disorder screener, the base rate and stability of its items and its measurement model have not been previously studied. We therefore examined the structure, longitudinal invariance, and stability of the Child Behavior Checklist 1½-5's Diagnostic and Statistical Manual of Mental Disorders-Autism Spectrum Problems Scale in the diverse Generation R (Rotterdam) sample based on mothers' ratings at 18 months ( n = 4695), 3 years ( n = 4571), and 5 years ( n = 5752)...
November 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29141559/new-histopathological-genetic-features-to-improve-active-surveillance-selection-for-low-risk-prostate-cancer
#11
Lih-Ming Wong, Kevin Chu, Niall Corcoran, Sam Norden
BACKGROUND: A recent surge in biomarkers to aid management of men with prostate cancer has occurred. Their applications are varied and not all tests are applicable to the active surveillance setting. OBJECTIVE: To review primary evidence on genetic and immunohistochemical biomarkers, and their role on patient selection and risk stratification for men on active surveillance for prostate cancer. EVIDENCE ACQUISITION: A PubMed electronic search using the terms (biomarker or genetic or histopathological) AND ("prostate cancer" AND "active surveillance") was performed from inception to April 2015...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29140404/evaluation-of-opportunities-to-improve-hematopathology-diagnosis-for-vietnam-pathologists
#12
Vanessa Dayton, Chi Kim Nguyen, Trinh Thu Van, Nguyen Van Thanh, Ta Van To, Nguyen Phi Hung, Nguyen Ngoc Dung, Danny A Milner
Objectives: We evaluate the need for, feasibility of, and impediments to improving hematopathology diagnoses for cancer hospitals in Vietnam. Methods: Two hematopathologists from the United States visited three major cancer treatment hospitals in Vietnam to workshop a sampling of difficult hematopathology cases. With Vietnamese pathologists, they toured histopathology, immunohistochemistry, and ancillary laboratory facilities. Results: Automated tissue processors and slide staining equipment were documented for each of the three hospitals...
November 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29139540/neurosphere-formation-potential-resides-not-in-the-caudal-cell-mass-but-in-the-secondary-neural-tube
#13
Ji Yeoun Lee, Eun Sun Lee, Saet Pyoul Kim, Myung-Sook Lee, Ji Hoon Phi, Seung-Ki Kim, Young-Il Hwang, Kyu-Chang Wang
The caudal cell mass (CCM) is known as the main player in secondary neurulation, forming the secondary neural tube (2NT). This suggests that the CCM may have the character of neural progenitor cells. The neural potential of the CCM and the 2NT (CCM + 2NT) was assessed by in vitro culture of neurospheres during Hamburger and Hamilton stages (HH) of secondary neurulation (HH16 to HH32). We also analyzed the neural potential of the developing central nervous system (CNS) by comparing the neurosphere culture from the brain, upper / lower spinal cord, and CCM + 2NT from various HH stages...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29136112/local-production-of-tenascin-c-acts-as-a-trigger-for-monocyte-macrophage-recruitment-that-provokes-cardiac-dysfunction
#14
Dounia Abbadi, Fanny Laroumanie, Mathilde Bizou, Joffrey Pozzo, Danièle Daviaud, Christine Delage, Denis Calise, Fréderique Gaits-Iacovoni, Marianne Dutaur, Florence Tortosa, Edith Renaud-Gabardos, Victorine Douin-Echinard, Anne-Catherine Prats, Jerome Roncalli, Angelo Parini, Nathalie Pizzinat
Aims: Tenascin-C (TNC) is an endogenous danger signal molecule strongly associated with inflammatory diseases and with poor outcome in patients with cardiomyopathies. Its function within pathological cardiac tissue during pressure overload remains poorly understood. Methods and results: We showed that TNC accumulates after 1 week of transverse aortic constriction (TAC) in the heart of 12-week-old male mice. By cross bone marrow transplantation experiments, we determined that TNC deposition relied on cardiac cells and not on haematopoietic cells...
November 10, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29132552/intravenous-drug-abuse-is-a-risk-factor-in-the-failure-of-two-stage-treatment-for-infected-total-hip-arthroplasty
#15
Yu-Jie Su, Sung-Yen Lin, Hsuan-Ti Huang, Je-Ken Chang, Chung-Hwan Chen
Reinfection after two-stage revision hip arthroplasty (RHA) is still a complex issue. Only few studies revealed the factors affecting the success rate in the treatment of periprosthetic hip infection (PHI), especially risk factors. A retrospective study was conducted using records of 30 patients underwent two-stage RHA for infected total hip arthroplasty (THA). Treatment was defined as successful if a patient did not need any reoperation or invasive procedure such as image-guided drainage during the two years after reimplantation...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29132421/durability-monitoring-of-long-lasting-insecticidal-mosquito-nets-llins-in-madagascar-physical-integrity-and-insecticidal-activity
#16
Sanjiarizaha Randriamaherijaona, Jacky Raharinjatovo, Sébastien Boyer
BACKGROUND: Long-lasting insecticidal mosquito nets (LLINs) are highly effective for malaria prevention. However, it is also clear that durability monitoring is essential to predict when, post-distribution, a net population, no longer meets minimum WHO standards and needs to be replaced. Following a national distribution campaign in 2013, we tracked two durability indicators, physical integrity and bio-efficacy at six and 12 months post-distribution. While the loss of net integrity during this period was in line with expectations for a one-year net life, bio-efficacy results suggested that nets were losing insecticidal effect faster than expected...
November 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29127068/mono-vs-multilayer-fibronectin-coatings-on-polar-hydrophobic-ionic-polyurethanes-altering-surface-interactions-with-human-monocytes
#17
Audrey Gossart, Kyle G Battiston, Adeline Gand, Emmanuel Pauthe, J Paul Santerre
Monocyte interactions with materials that are biofunctionalized with fibronectin (Fn) are of interest because of the documented literature which associates this protein with white blood cell function at implant sites. A degradable-polar hydrophobic ionic polyurethane (D-PHI), has been reported to promote an anti-inflammatory response from human monocytes. The aim of the current work was to study the influence of intrinsic D-PHI material chemistry on Fn adsorption (mono and multi-layer structures), and to investigate the influence of such chemistry on the structural state of the Fn, as well as the latter's influence on the activity of human monocytes on the protein coated substrates...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29126118/decentralized-and-reproducible-geocoding-and-characterization-of-community-and-environmental-exposures-for-multisite-studies
#18
Cole Brokamp, Chris Wolfe, Todd Lingren, John Harley, Patrick Ryan
Objective: Geocoding and characterizing geographic, community, and environmental characteristics of study participants is frequently done in epidemiological studies. However, participant addresses are identifiable protected health information (PHI) and geocoding must be conducted in a Health Insurance Portability and Accountability Act-compliant manner. Our objective was to create a software application for this process that addresses limitations in current approaches. Materials and Methods: We used a containerization platform to create DeGAUSS (Decentralized Geomarker Assessment for Multi-Site Studies), a software application that facilitates reproducible geocoding and geomarker assessment while maintaining the confidentiality of PHI...
November 8, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29125332/abo-blood-group-related-venous-thrombosis-risk-in-patients-with-peripherally-inserted-central-catheters
#19
Chung Mo Koo, Ravi Vissapragada, Rebecca Sharp, Phi Nguyen, Thomas Ung, Chrismin Solanki, Adrian Esterman
OBJECTIVE: To investigate the association between ABO blood group and venous thrombosis (VT) risk in patients with peripherally inserted central catheters (PICC). METHODS: Single centre retrospective cohort study. A cohort of patients who underwent PICC insertion from September 2010 to August 2014 were followed up for symptomatic VT presentations diagnosed by ultrasound. Blood group status was identified from hospital information systems. RESULTS: 2270 participants had 3020 PICCs inserted...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29112516/intravoxel-incoherent-motion-analysis-of-abdominal-organs-application-of-simultaneous-multislice-acquisition
#20
Valerie Doan Phi Van, Anton S Becker, Alexander Ciritsis, Caecilia S Reiner, Andreas Boss
PURPOSE: The aim of this study was to systematically evaluate the accuracy of quantitative intravoxel incoherent motion (IVIM) analysis of the upper abdomen applying simultaneous multislice (SMS) diffusion-weighted imaging (DWI) to reduce acquisition time. MATERIALS AND METHODS: Diffusion-weighted imaging of parenchymal abdominal organs was performed in 8 healthy volunteers at 3 T using a standard DWI sequence (acceleration factor 1 [AF1]) and an SMS-accelerated echo planar imaging sequence with acceleration factors 2 and 3 (AF2/AF3)...
November 6, 2017: Investigative Radiology
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