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https://www.readbyqxmd.com/read/28646250/assessing-competence-at-a-higher-level-among-older-adults-development-of-the-japan-science-and-technology-agency-index-of-competence-jst-ic
#1
Hajime Iwasa, Yukie Masui, Hiroki Inagaki, Yuko Yoshida, Hiroyuki Shimada, Rika Otsuka, Kazunori Kikuchi, Kumiko Nonaka, Hiroto Yoshida, Hideyo Yoshida, Takao Suzuki
BACKGROUND AND AIMS: Older adults' ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agency Index of Competence (JST-IC) via item analysis and assessed its psychometric properties. METHODS: Participants were 1306 community-dwelling older adults (623 men and 683 women, 74.0 ± 2.8 years old) who completed the 54-item draft JST-IC to determine their level of independence...
June 23, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28644679/success-of-university-student-volunteers-in-obtaining-consent-for-reviewing-private-health-information-for-emergency-research
#2
Adam I Kramer, Elizabeth Stephenson, Adam Betel, Johanna Crudden, Kathy Boutis
OBJECTIVES: This study aimed to determine the success of university student volunteers in obtaining consent from parents to allow review of their child's personal health information (PHI) for emergency research screening. This study also aimed to examine the variables associated with successful consent. METHODS: This was a prospective cross-sectional study conducted at a pediatric emergency department (ED). University students, who functioned as delegates of the health information custodian, approached parents for consent...
June 23, 2017: Accountability in Research
https://www.readbyqxmd.com/read/28644571/difference-between-respiratory-epithelial-adenomatoid-hamartomas-and-small-malignant-tumors-of-the-olfactory-cleft-on-ct-scans-in-forty-six-patients
#3
Théophile De Saint Hilaire, Cécile Rumeau, Patrice Gallet, Phi-Linh Nguyen-Thi, Roger Jankowski, Duc Trung Nguyen
Misdiagnosis of respiratory epithelial adenomatoid hamartomas for malignant tumors can lead to an aggressive surgical procedure, which is not necessary in the case of a respiratory epithelial adenomatoid hamartoma. Detailed analysis of sinonasal CT scans without contrast can help to distinguish respiratory epithelial adenomatoid hamartomas of the olfactory cleft from small malignant tumors (T1 and T2) of the olfactory clefts. Criteria in favor of diagnosis of small malignant tumors of the olfactory clefts on CT scans without contrast were unilaterality of masses in the olfactory clefts, large olfactory clefts /small olfactory clefts ratio ≥ 2 (sensibility at 91% and specificity at 100%), and presence of bone erosion...
June 23, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28642158/genetic-diversity-of-environmental-vibrio-cholerae-o1-strains-isolated-in-northern-vietnam
#4
Taichiro Takemura, Kazunori Murase, Fumito Maruyama, Tran Thi Luong, Atsushi Ota, Ichiro Nakagawa, Nguyen Dong Tu, Ngo Tu Cuong, Nguyen Thi Hang, Asako Tokizawa, Masatomo Morita, Makoto Ohnishi, Nguyen Binh Minh, Tetsu Yamashiro
Cholera epidemics have been recorded periodically in Vietnam during the seventh cholera pandemic. Since cholera is a water-borne disease, systematic monitoring of environmental waters for Vibrio cholerae presence is important for predicting and preventing cholera epidemics. We conducted monitoring, isolation, and genetic characterization of V. cholerae strains in Nam Dinh province of Northern Vietnam from Jul 2013 to Feb 2015. In this study, four V. cholerae O1 strains were detected and isolated from 110 analyzed water samples (3...
June 19, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28641267/a-cpu-mic-collaborated-parallel-framework-for-gromacs-on-tianhe-2-supercomputer
#5
Shaoliang Peng, Shunyun Yang, Wenhe Su, Xiaoyu Zhang, Tenglilang Zhang, Weiguo Liu, Xingming Zhao
Molecular Dynamics (MD) is the simulation of the dynamic behavior of atoms and molecules. As the most popular software for molecular dynamics, GROMACS cannot work on large-scale data because of limit computing resources. In this paper, we propose a CPU and Intel® Xeon Phi Many Integrated Core (MIC) collaborated parallel framework to accelerate GROMACS using the offload mode on a MIC coprocessor, with which the performance of GROMACS is improved significantly, especially with the utility of Tianhe-2 supercomputer...
June 16, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28632271/copper-promoted-direct-c-h-alkoxylation-of-s-s-functionalized-internal-olefins-with-alcohols
#6
Zhuqing Liu, Fei Huang, Jiang Lou, Quannan Wang, Zhengkun Yu
Copper-promoted direct C-H alkoxylation of S,S-functionalized internal olefins, that is, α-oxo ketene dithioacetals, was efficiently achieved with alcohols as the alkoxylating agents, (diacetoxyiodo)benzene (PhI(OAc)2) as the oxidant, and benzoquinone (BQ) as the co-oxidant. The alkoxylated olefins were thus constructed and applied for the synthesis of alkoxylated N-heterocycles. The polarization of the olefinic carbon-carbon double bond by the electron-donating dialkylthio and electron-withdrawing α-oxo functionalities plays a crucial role in making such C-H alkoxylation reactions to occur under mild conditions...
June 20, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28629569/in-depth-analysis-of-interreader-agreement-and-accuracy-in-categorical-assessment-of-brown-adipose-tissue-in-18-fdg-pet-ct
#7
Anton S Becker, Caroline Zellweger, Khoschy Schawkat, Sanja Bogdanovic, Valerie Doan Phi van, Hannes W Nagel, Christian Wolfrum, Irene A Burger
PURPOSE: To evaluate the interreader agreement of a three-tier craniocaudal grading system for brown fat activation and investigate the accuracy of the distinction between the three grades. MATERIALS AND METHODS: After IRB approval, 340 cases were retrospectively selected from patients undergoing (18)FDG-PET/CT between 2007 and 2015 at our institution, with 85 cases in each grade and 85 controls with no active brown fat. Three readers evaluated all cases independently...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28624169/dynamic-change-in-optic-nerve-after-intracranial-pressure-reduction-in-children
#8
Won June Lee, Hae Jin Kim, Ki Ho Park, Yong Woo Kim, Michael J A Girard, Jean Martial Mari, Seung-Ki Kim, Ji Hoon Phi, Jin Wook Jeoung
No abstract text is available yet for this article.
June 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28622459/structural-plasticity-among-glutathione-transferase-phi-members-natural-combination-of-catalytic-residues-confers-dual-biochemical-activities
#9
Henri Pégeot, Sandrine Mathiot, Thomas Perrot, Frédéric Gense, Arnaud Hecker, Claude Didierjean, Nicolas Rouhier
The glutathione transferase (GST) gene family is divided into fourteen classes in photosynthetic organisms. Among them, the Phi class (GSTF) is composed of a large number of genes that are often induced in response to environmental constraints due to their ability to detoxify xenobiotics, to their peroxidase activity and to their involvement in the biosynthesis and/or transport of secondary metabolites. However, the exact functions of GSTFs from many plants including Populus trichocarpa are unknown. Here, following GSTF1 characterization, we have performed a comparative analysis of the seven other GSTFs found in poplar by systematically evaluating the biochemical and enzymatic properties of the corresponding recombinant proteins and of variants mutated for active site residues and by determining the three-dimensional structures of several representatives...
June 16, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28621927/hemocompatibility-of-degrading-polymeric-biomaterials-degradable-polar-hydrophobic-ionic-polyurethane-d-phi-vs-poly-lactic-co-glycolic-acid-plga
#10
Kathryne Saini Brockman, Benjamin F L Lai, Jayachandran N Kizhakkedathu, J Paul Santerre
The use of degradable polymers in vascular tissue regeneration has sparked the need to characterize polymer biocompatibility during degradation. While tissue compatibility has been frequently addressed, studies on polymer hemocompatibility during degradation are limited. The current study evaluated the differences in hemocompatibility (platelet response, complement activation, and coagulation cascade initiation) between as-made and hydrolyzed poly(lactic-co-glycolic) acid (PLGA) and degradable polar hydrophobic ionic polyurethane (D-PHI)...
June 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28615156/dr-google-is-here-to-stay-but-health-care-professionals-are-still-valued-an-analysis-of-health-care-consumers-internet-navigation-support-preferences
#11
Kenneth Lee, Kreshnik Hoti, Jeffery David Hughes, Lynne Emmerton
BACKGROUND: The Internet offers great opportunities for consumers to be informed about their health. However, concerns have been raised regarding its impact on the traditional health consumer-health professional relationship. Our recent survey of 400 Australian adults identified that over half of consumers required some form of navigational support in locating appropriate Web-based health information. We propose that support provided by health professionals would be preferred by consumers; this preference is regardless of whether consumers have a need for navigational support...
June 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28614144/early-fibrinolysis-associated-with-hemorrhagic-progression-following-traumatic-brain-injury
#12
Jay Karri, Jessica C Cardenas, Nena Matijevic, Yao-Wei Wang, Sangbum Choi, Liang Zhu, Bryan A Cotton, Ryan Kitagawa, John B Holcomb, Charles E Wade
BACKGROUND: Progressive hemorrhagic injury (PHI) is common in patients with severe traumatic brain injury (TBI) and is associated with worse outcomes. PHI pathophysiology remains poorly understood and difficult to predict. We performed an exploratory analysis aimed at identify markers in need of further investigation to establish their predictive value in PHI following TBI. METHODS: We performed a retrospective chart review of prospectively collected data from 424 highest-level activation trauma patients from January 2012 through December 2013...
June 13, 2017: Shock
https://www.readbyqxmd.com/read/28610190/-i-pseudoleptonema-i-i-tansoongnerni-i-new-species-hydropsychidae-trichoptera-with-species-list-of-trichoptera-from-li-phi-falls-mekong-river-southern-laos
#13
Pongsak Laudee, Hans Malicky
A new species named Pseudoleptonema tansoongnerni n. sp. is presented along with a list of Trichoptera from Li Phi falls, Mekong River, southern Laos. Pseudoleptonema tansoongnerni n. sp. is described and figured based on adult males and females. It is distinguished from the others by its forewing pattern and color, which is yellowish brown.
March 10, 2017: Zootaxa
https://www.readbyqxmd.com/read/28607597/psa-and-prostate-health-index-based-prostate-cancer-screening-in-a-hereditary-migration-complicated-population-implications-in-precision-diagnosis
#14
Mariyam Akizhanova, Elzira E Iskakova, Valdemir Kim, Xiao Wang, Roman Kogay, Aiym Turebayeva, Qinglei Sun, Ting Zheng, Shenghui Wu, Lixia Miao, Yingqiu Xie
Precision diagnosis requires specific markers for differential ethnic populations. Prostate-Specific Antigen (PSA) level (threshold of 4ng/ml) has been widely used to screen prostate cancer and as reference of pro-biopsy but false diagnosis frequently occurs. Prostate health Index (PHI) is a new diagnosis marker which combines PSA, free PSA and p2PSA4. Overall the PCa screening database is lacking in Kazakhstani patients. We analyzed the PSA levels and Gleason scores of 222 biopsies collected in 2015 in Almaty area, Kazakhstan approved by institutional ethics board...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28607236/sri-lanka-s-national-assessment-on-innovation-and-intellectual-property-for-access-to-medical-products
#15
Hemantha Beneragama, Manisha Shridhar, Thushara Ranasinghe, Vajira Hw Dissanayake
In 2008, the Global strategy and plan of action on public health, innovation and intellectual property (GSPA-PHI) was launched by the World Health Organization, to stimulate fresh thinking on innovation in, and access to, medicines and to build sustainable research on diseases disproportionately affecting low- and middle-income countries. As part of the activities of the GSPA-PHI, Sri Lanka has been the first country to date to assess the national environment for medical technology and innovation. This year-long, multistakeholder, participative analysis facilitated identification of clear and implementable policy recommendations, for the government to increase its effectiveness in promoting innovation in health products through institutional development, investment and coordination among all areas relevant to public health...
September 2016: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28603990/hypervalent-iodine-iii-mediated-decarboxylative-ritter-type-amination-leading-to-the-production-of-%C3%AE-tertiary-amine-derivatives
#16
Kensuke Kiyokawa, Tomoki Watanabe, Laura Fra, Takumi Kojima, Satoshi Minakata
α-Tertiary amines (ATAs) are attractive structural motifs that are frequently found in biologically active molecules. Therefore, the development of an efficient method for the synthesis of ATAs represents an important research topic in the field of medicinal chemistry as well as organic chemistry. Although the Ritter reaction is a reliable approach for preparing α-tertiary amine derivatives via intermolecular amination reactions, the typical methods suffer from disadvantages such as harsh reaction conditions and the use of strong acids...
June 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28602908/learning-to-identify-protected-health-information-by-integrating-knowledge-and-data-driven-algorithms-a-case-study-on-psychiatric-evaluation-notes
#17
Azad Dehghan, Aleksandar Kovacevic, George Karystianis, John A Keane, Goran Nenadic
De-identification of clinical narratives is one of the main obstacles to making healthcare free text available for research. In this paper we describe our experience in expanding and tailoring two existing tools as part of the 2016 CEGS N-GRID Shared Tasks Track 1, which evaluated de-identification methods on a set of psychiatric evaluation notes for up to 25 different types of Protected Health Information (PHI). The methods we used rely on machine learning on either a large or small feature space, with additional strategies, including two-pass tagging and multi-class models, which both proved to be beneficial...
June 7, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28602904/a-hybrid-approach-to-automatic-de-identification-of-psychiatric-notes
#18
Hee-Jin Lee, Yonghui Wu, Yaoyun Zhang, Jun Xu, Hua Xu, Kirk Roberts
De-identification, or identifying and removing protected health information (PHI) from clinical data, is a critical step in making clinical data available for clinical applications and research. This paper presents a natural language processing system for automatic de-identification of psychiatric notes, which was designed to participate in the 2016 CEGS N-GRID shared task Track 1. The system has a hybrid structure that combines machine leaning techniques and rule-based approaches. The rule-based components exploit the structure of the psychiatric notes as well as characteristic surface patterns of PHI mentions...
June 7, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28602352/cryo-em-reveals-how-human-cytoplasmic-dynein-is-auto-inhibited-and-activated
#19
Kai Zhang, Helen E Foster, Arnaud Rondelet, Samuel E Lacey, Nadia Bahi-Buisson, Alexander W Bird, Andrew P Carter
Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin. Here, we present a cryoelectron microscopy structure of the complete 1.4-megadalton human dynein-1 complex in an inhibited state known as the phi-particle. We reveal the 3D structure of the cargo binding dynein tail and show how self-dimerization of the motor domains locks them in a conformation with low microtubule affinity...
June 15, 2017: Cell
https://www.readbyqxmd.com/read/28599306/panobinostat-a-histone-deacetylase-inhibitor-suppresses-leptomeningeal-seeding-in-a-medulloblastoma-animal-model
#20
Ji Hoon Phi, Seung Ah Choi, Pil Ae Kwak, Ji Yeoun Lee, Kyu-Chang Wang, Do Won Hwang, Seung-Ki Kim
Leptomeningeal seeding is a strong negative prognostic factor for medulloblastoma (MB). The mechanism of leptomeningeal seeding is unclear but may involve epigenetic regulation. In this study, we evaluated the feasibility of a histone deacetylase (HDAC) inhibitor, panobinostat, in the suppression of MB leptomeningeal seeding.Panobinostat decreased the cell viability and proliferation, inducing cell cycle arrest and apoptosis in MB cell lines. The migration and adhesion capabilities were significantly decreased...
May 24, 2017: Oncotarget
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