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https://www.readbyqxmd.com/read/27923711/characterization-of-na-transport-to-gain-insight-into-the-mechanism-of-acid-base-and-ion-regulation-in-white-sturgeon-acipenser-transmontanus
#1
Ryan B Shartau, Kevin V Brix, Colin J Brauner
Freshwater fish actively take up ions via specific transporters to counter diffusive losses to their hypotonic environment. While much is known about the specific mechanisms employed by teleosts, almost nothing is known about the basal fishes, such as white sturgeon (Acipenser transmontanus) which may offer insight into the evolution of osmo- and ionoregulation in fishes. We investigated Na(+) uptake in juvenile white sturgeon in the presence and absence of transporter inhibitors. We found that sturgeon acclimated to 100μmol 1(-1) Na(+) have Na(+) uptake kinetics typical of teleosts and that a Na(+)/H(+) exchanger (NHE) is the predominant transporter for Na(+) uptake...
December 3, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27922627/blood-based-and-urinary-prostate-cancer-biomarkers-a-review-and-comparison-of-novel-biomarkers-for-detection-and-treatment-decisions
#2
REVIEW
R J Hendriks, I M van Oort, J A Schalken
BACKGROUND: The diagnosis of prostate cancer (PCa) is currently based on serum PSA testing and/or abnormal digital rectal examination and histopathologic evaluation of prostate biopsies. The main drawback of PSA testing is the lack of specificity for PCa. To improve early detection of PCa more specific biomarkers are needed. In the past few years, many new promising biomarkers have been identified; however, to date, only a few have reached clinical practice. METHODS: In this review, we discuss new blood-based and urinary biomarker models that are promising for usage in PCa detection, follow-up and treatment decision-making...
December 6, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27919903/high-throughput-screening-and-prediction-models-building-for-novel-hemozoin-inhibitors-using-physicochemical-properties
#3
Nguyen Tien Huy, Pham Lan Chi, Jun Nagai, Tran Ngoc Dang, Evaristus Chibunna Mbanefo, Ali Mahmoud Ahmed, Nguyen Phuoc Long, Le Thi Bich Thoa, Le Phi Hung, Titouna Afaf, Kaeko Kamei, Hiroshi Ueda, Kenji Hirayama
It is essential to continue the search for novel antimalarial drugs due to current spread of resistance against artemisinin by Plasmodium falciparum parasites. In this study, we developed in silico models to predict hemozoin inhibitors as a potential first-step screening for novel antimalarials. The in vitro colorimetric high throughput screening assay of hemozoin formation was used to identify hemozoin inhibitors from 9600 structurally diverse compounds. Physicochemical properties of positive hits and randomly selected compounds were extracted from ChemSpider database; they were used for developing prediction models to predict hemozoin inhibitors using two different approaches, i...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27916788/effects-of-dietary-oregano-essential-oil-and-vitamin-e-supplementation-on-meat-quality-stress-response-and-intestinal-morphology-in-pigs-following-transport-stress
#4
Yi Zou, Xiao Ming Hu, Ting Zhang, Hong Kui Wei, Yuan Fei Zhou, Zhong Xin Zhou, Jian Peng
This study investigates the effects of dietary oregano essential oil (OEO) and vitamin E (Vit E) supplementation on meat quality, stress response and intestinal morphology in pigs following transport stress. A total of 288 finishing pigs were randomly assigned to three groups: a basal diet or a basal diet supplemented either with 200 mg/kg Vit E or 25 mg/kg OEO. After a 28-day feeding trial, total of 132 finishing pigs according diet and transport stress were assigned to one of four treatment groups: 1) control treatment without transport stress (Control group), 2) control treatment with 5-hr transport stress (Negative group), 3) Vit E treatment with 5-hr transport stress and 4) OEO treatment with 5-hr transport stress...
December 2, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27915230/phi-base-a-new-interface-and-further-additions-for-the-multi-species-pathogen-host-interactions-database
#5
Martin Urban, Alayne Cuzick, Kim Rutherford, Alistair Irvine, Helder Pedro, Rashmi Pant, Vidyendra Sadanadan, Lokanath Khamari, Santoshkumar Billal, Sagar Mohanty, Kim E Hammond-Kosack
The pathogen-host interactions database (PHI-base) is available at www.phi-base.org PHI-base contains expertly curated molecular and biological information on genes proven to affect the outcome of pathogen-host interactions reported in peer reviewed research articles. In addition, literature that indicates specific gene alterations that did not affect the disease interaction phenotype are curated to provide complete datasets for comparative purposes. Viruses are not included. Here we describe a revised PHI-base Version 4 data platform with improved search, filtering and extended data display functions...
December 3, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27894244/umbelliferone-decreases-intracellular-ph-and-sensitizes-melanoma-cell-line-a375-to-dacarbazin-comparison-with-acetazolamide
#6
Clémentine Puech, Morgane Chatard, Delphine Felder-Flesch, Nathalie Prevot, Nathalie Perek
The high degree of malignancy of tumour cells is linked to alterations of many physiological parameters like the intracellular pH (pHi). The pHi in cancer cell line is regulated by the anhydrase carbonique IX (CA IX). The main enzymatic function of the CA IX protein is to catalyze the hydration of carbon dioxide into bicarbonate ions and protons. Inhibiton of transmembrane tumor associated isozyme carbonic anhydrase IX (CA IX) with specific inhibitors is a promising and expanding field as CA IX is involved in tumor progression...
November 28, 2016: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/27889890/protective-role-of-quercetin-against-hematotoxic-and-immunotoxic-effects-of-furan-in-rats
#7
Rasha T Alam, Ehsan H Abu Zeid, Tamer S Imam
Furan (Fu) is a liver carcinogen produced during heating process of food and concerns a public health problem. The current study was undertaken to evaluate the protective role of quercetin (Que) on Fu-induced hematological, immunological, and histopathological alterations in rats. Fifty male Sprague Dawley rats were divided into five equal groups. Group I (Cont) received distilled water, group II (CO) received corn oil, group III (Que) received Que at 50 mg/kg BW, group IV (Fu) received Fu at 16 mg/kg BW, and group V received Que + Fu simultaneously; all groups gavaged daily for 30 days...
November 26, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27888006/physicochemical-characteristics-and-in-vitro-digestibility-of-potato-and-cassava-starches-under-organic-acid-and-heat-moisture-treatments
#8
Pham Van Hung, Nguyen Thi Mai Huong, Nguyen Thi Lan Phi, Nguyen Ngoc Thanh Tien
A combination of acid (citric acid or lactic acid) and heat-moisture treatment was used to modify cassava and potato starches in this study. Changes in physicochemical properties and in vitro digestibility of the treated starches were investigated. The cassava starch contained 17.0% amylose and possessed A-type crystallinity, whereas the potato starch had 27.4% amylose and possessed B-type crystallinity. After acid and heat-moisture treatment, the crystalline structure of the cassava starch remained unchanged (A type), while the crystalline structure of the potato starch changed from B type to the C (B+A) type...
November 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27887844/anthraquinones-from-morinda-longissima-and-their-insulin-mimetic-activities-via-amp-activated-protein-kinase-ampk-activation
#9
Phi-Hung Nguyen, Hong Seok Choi, Thi Kim Quy Ha, Ji Yeon Seo, Jun-Li Yang, Da-Woon Jung, Darren R Williams, Won-Keun Oh
AMP-activated protein kinase (AMPK) activators are known to increase energy metabolism and to reduce body weight, as well as to improve glucose uptake. During for searching AMPK activators, a new anthraquinone, modasima A (10), along with eighteen known analogues (1-9 and 11-19) were isolated from an ethanol extract of the roots of Morinda longissima Y. Z. Ruan (Rubiaceae). Using the fluorescent tagged glucose analogues, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxy-D-glucose (2-NBDG), insulin mimetics were screened with compounds 1-19 in 3T3-L1 adipocytes...
November 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27881156/klotho-sensitive-regulation-of-dendritic-cell-functions-by-vitamin-e
#10
Nguyen Thi Xuan, Phi Thi Thu Trang, Nguyen Van Phong, Nguyen Linh Toan, Do Minh Trung, Nguyen Duy Bac, Viet Linh Nguyen, Nguyen Huy Hoang, Nong Van Hai
BACKGROUND: Dendritic cells (DCs) are the most potent professional antigen-presenting cells for naive T cells to link innate and acquired immunity. Klotho, an anti-aging protein, participates in the regulation of Ca(2+) dependent migration in DCs. Vitamin E (VitE) is an essential antioxidant to protect cells from damage and elicits its inhibitory effects on NF-κB-mediated inflammatory response. However, the roles of VitE on mouse DC functions and the contribution of klotho to those effects both are unknown...
November 24, 2016: Biological Research
https://www.readbyqxmd.com/read/27878835/first-line-therapy-for-chronic-lymphocytic-leukemia-in-patients-older-than-79%C3%A2-years-is-feasible-and-achieves-good-results-a-filo-retrospective-study
#11
Godelieve Meunier, Loic Ysebaert, Phi Linh Nguyen-Thi, Stéphane Lepretre, Anne Quinquenel, Jehan Dupuis, Richard Lemal, Thérèse Aurran, Cécile Tomowiak, Florence Cymbalista, Marie Sarah Dilhuydy, Annie Brion, Pierre Morel, Bruno Cazin, Véronique Leblond, Guillaume Cartron, Daniel Ré, Marie Christine Béné, Anne Sophie Michallet, Pierre Feugier
The mean age at diagnosis of chronic lymphocytic leukemia (CLL) is 72 years, with 22.8% of patients being older than 80 years. However, the elderly are underrepresented in clinical studies of CLL. We performed a retrospective study of CLL patients aged 80 years or older at the initiation of first-line therapy in hospitals affiliated with the French intergroup on CLL (French Innovative Leukemia Organization) between 2003 and 2013. Here, we describe the clinical and biological characteristics, treatment, and outcomes for 201 patients...
November 22, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27878126/validity-of-the-electronic-triage-system-in-predicting-patient-outcomes-in-tabriz-iran-a-cross-sectional-study
#12
Faramarz Pourasghar, Jafar Sadegh Tabrizi, Alireza Ala, Amin Daemi
OBJECTIVE: To validate the triage ratings performed by the Electronic Triage System (ETS) using hospitalization, length of stay, resource use, in-hospital mortality and patient bills as outcome measures. METHODS: In this retrospective cross-sectional study the medical records of 387 patients were reviewed in a one-week period. The data included triage category and the outcome measures were hospitalization, length of stay, in-hospital mortality, patient bill, and used resources...
October 2016: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/27872386/transformational-leadership-in-primary-care-clinicians-patterned-approaches-to-care-predict-patient-satisfaction-and-health-expectations
#13
Ho Phi Huynh, Kate Sweeny, Tricia Miller
Clinicians face the complex challenge of motivating their patients to achieve optimal health while also ensuring their satisfaction. Inspired by transformational leadership theory, we proposed that clinicians' motivational behaviors can be organized into three patient care styles (transformational, transactional, and passive-avoidant) and that these styles differentially predict patient health outcomes. In two studies using patient-reported data and observer ratings, we found that transformational patient care style positively predicted patients' satisfaction and health expectations above and beyond transactional and passive-avoidant patient care style...
November 21, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27865174/maraviroc-in-addition-to-cart-during-primary-hiv-infection-results-from-main-randomized-clinical-trial-and-96-weeks-follow-up
#14
Marco Ripa, Manuela Pogliaghi, Stefania Chiappetta, Silvia Nozza, Alessandro Soria, Giacomo Coppalini, Cristina Rovelli, Giuseppe Tambussi
BACKGROUND: Multi-targeted treatment strategies including maraviroc (MVC) during Primary HIV Infection (PHI) may benefit from the immune-modulatory properties of this CCR5-inhibitor. OBJECTIVES: We conducted a proof-of-concept clinical trial aimed at assessing whether maraviroc in addition of a combination antiretroviral therapy (cART) initiated during PHI would improve immunological and virological parameters. STUDY DESIGN: The MAIN (Maraviroc in HIV Acute INfection) study was a randomized open-label clinical trial (EUDRACT number: 2008-007004-29) which enrolled 29 patients with PHI...
October 31, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27861954/special-trends-in-cbf-and-dreb2-groups-in-eucalyptus-gunnii-vs-eucalyptus-grandis-suggest-that-cbf-are-master-players-in-the-trade-off-between-growth-and-stress-resistance
#15
Hong C Nguyen, Phi B Cao, Hélène San Clemente, Raphaël Ployet, Fabien Mounet, Natalie Ladouce, Luc Harvengt, Christiane Marque, Chantal Teulieres
Annotation of the Eucalyptus grandis genome showed a large amplification of the DREB1/CBF group without recent DREB2 gene duplication compared to other plant species. The present annotation of the CBF and DREB2 genes from a draft of the Eucalyptus gunnii genome sequence reveals at least an additional CBF copy in the E. gunnii genome compared to E. grandis, suggesting that this group is still evolving, unlike the DREB2 group. This study aims to investigate the redundancy/neo- or sub-functionalization of the duplicates and the relative involvement of the two groups in abiotic stress responses in both E...
November 16, 2016: Physiologia Plantarum
https://www.readbyqxmd.com/read/27860526/medication-identification-in-pediatric-asthma-med-id-the-reliability-and-validity-of-a-novel-screening-tool
#16
Sean M Frey, I Diana Fernandez, Deborah J Ossip, Jill S Halterman
OBJECTIVES: To evaluate the reliability and validity of MED ID, a novel survey assessing caregiver-perceived ability to identify inhaled asthma medications. METHODS: We analyzed baseline data from the School-Based Asthma Care for Teens (SB-ACT) trial in Rochester, NY. Caregivers of adolescents with persistent asthma named the inhaled medications used by their child, and identified medications on a pictorial chart. Accurate identification was defined as completed matches between listed names and selected images...
November 18, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27855567/pradigastat-disposition-in-humans-in-vivo-and-in-vitro-investigations
#17
Alana Upthagrove, Jin Chen, Charles D Meyers, Kenneth Kulmatycki, Angela Bretz, Lai Wang, Lana Peng, Safet Palamar, Melissa Lin, Tapan Majumdar, Phi Tran, Heidi J Einolf
1. Pradigastat is a potent and specific diacylglycerol acyltransferase-1 (DGAT1) inhibitor effective in lowering postprandial triglycerides in healthy human subjects and fasting triglycerides in familial chylomicronemia syndrome (FCS) patients. 2. Here we present the results of human oral absorption, metabolism and excretion (AME), intravenous pharmacokinetic (PK), and in vitro studies which together provide an overall understanding of the disposition of pradigastat in humans. 3. In human in vitro systems, pradigastat is metabolized slowly to a stable acyl glucuronide (M18...
November 18, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27855318/a-method-for-measuring-the-three-dimensional-orientation-of-cortical-canals-with-implications-for-comparative-analysis-of-bone-microstructure-in-vertebrates
#18
Isaac Vorster Pratt, David Michael Lane Cooper
The orientation of vascular canals in cortical bone can reveal information about the growth rate and loading environment of a bone. For example, in birds it has been proposed that a high proportion of circumferential canals (a laminar cortex) is related to fast growth or torsional loading related to active flight. In this paper we present a method to measure the three dimensional (3D) orientation of vascular canals. Image data are obtained from micro-CT and two angles are measured: phi, determining how longitudinal a canal is; and theta, determining whether a canal is radial or circumferential...
November 2, 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27852071/interferon-induced-transmembrane-protein-1-ifitm1-is-required-for-the-progression-of-colorectal-cancer
#19
Ita Novita Sari, Ying-Gui Yang, Lan Thi Hanh Phi, Hyungjoo Kim, Moo Jun Baek, Dongjun Jeong, Hyog Young Kwon
Interferon-induced transmembrane protein 1 (IFITM1) has been shown to be implicated in multiple cancers, yet little is known about biological significance of IFITM1 in colorectal cancer. Here, we show that IFITM1 is highly expressed in metastatic colorectal cancer cell lines as well as colorectal patient-derived tumor samples, and its expression is associated with a poor prognosis of the disease. Also, IFITM1 depletion resulted in a significant reduction in the mobility of cancer cell lines, whereas ectopic expression of IFITM1 promoted the migration of cancer cells...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27852054/a-novel-histone-deacetylase-inhibitor-ckd5-has-potent-anti-cancer-effects-in-glioblastoma
#20
Seung Ah Choi, Pil Ae Kwak, Chul-Kee Park, Kyu-Chang Wang, Ji Hoon Phi, Ji Yeoun Lee, Chang Sik Lee, Ju-Hee Lee, Seung-Ki Kim
There have been extensive efforts to improve the outcome of glioblastoma, but the prognosis of this disease has not been significantly altered to date. Histone deacetylase inhibitors (HDACIs) have been evaluated as promising anti-cancer drugs and regulate cell growth, cell cycle arrest and apoptosis in glioblastoma. Here, we demonstrated the therapeutic efficacy of a novel pan-HDACI, 7-ureido-N-hydroxyheptanamide derivative (CKD5), compared with traditional pan-HDACIs, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), in vitro and in vivo...
November 10, 2016: Oncotarget
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