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https://www.readbyqxmd.com/read/29786588/-infectious-complications-of-prostate-biopsy
#1
Marcin Łykowski, Bartosz Dybowski, Sławomir Poletajew, Tomasz Piecha, Piotr Radziszewski
Prostate cancer is the second most common malignancy in men in Poland. Prostate biopsy remains the gold standard for diagnosis. Every year, the number of procedures is increasing, so knowledge of possible complications is becoming crucial. Over time, a continuous increase in infectious complications of prostate biopsy is observed, so it is important to identify risk factors and preventive methods. Antibiotic prophylaxis is mandatory for prostate biopsy. Simultaneously, complications after prostate biopsy affect as many as 90% of patients, including up to 17% of infective complications...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29784633/confocal-laser-endomicroscopy-and-optical-coherence-tomography-for-the-diagnosis-of-prostate-cancer-a-needle-based-in-vivo-feasibility-study-protocol-ideal-phase-2a
#2
Abel Swaan, Christophe K Mannaerts, Matthijs Jv Scheltema, Jakko A Nieuwenhuijzen, C Dilara Savci-Heijink, Jean Jmch de la Rosette, R Jeroen A van Moorselaar, Ton G van Leeuwen, Theo M de Reijke, Daniel Martijn de Bruin
BACKGROUND: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information...
May 21, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29732206/patient-experience-after-transperineal-template-prostate-biopsy-compared-to-prior-transrectal-ultrasound-guided-prostate-biopsy
#3
Nikita R Bhatt, Kieran Breen, Usman M Haroon, Muhammad Akram, Hugh D Flood, Subhasis K Giri
Introduction: Transperineal template prostate biopsy (TTPB) is reported to have higher cancer detection and lower complication rate compared to transrectal ultrasound guided prostate biopsy (TRUSPB).However, there is no report of the same patient's experience with both types of biopsy.To compare the patient reported experience in the same cohort of patients who underwent both TRUSPB and TTPB, using validated questionnaires. Material and methods: We retrospectively utilised the Patient Reported Outcome Methods (PROM) tool validated for TRUSPB and the International Index of Erectile Function (IIEF-5) questionnaire to collect longitudinal data at follow-up in the same cohort of patients who underwent both TTPB and TRUSPB between January 2015 and February 2016...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29700974/interpolation-to-define-clinical-tumor-stage-in-prostate-cancer-using-clinical-description-of-digital-rectal-examination
#4
Sue M Evans, Declan G Murphy, Ian D Davis, Shomik Sengupta, Ehsan Zare Borzeshi, Fanny Sampurno, Jeremy L Millar
AIM: This study aims to assess characteristics of patients with prostate cancer for whom clinical T stage category (cT) was not documented in the medical record and assess whether specialists had concordant conclusions regarding cT based on digital rectal examination (DRE) notes. METHODS: Data from the Prostate Cancer Outcome Registry - Victoria (PCOR-Vic) were interrogated. Four specialists independently assigned cT to DRE notes. Words, or part thereof, associated with agreement between clinicians were identified...
April 27, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29697470/update-on-techniques-to-prevent-infections-associated-with-prostate-needle-biopsy
#5
Matteo Fontana, Luca Boeri, Emanuele Montanari
PURPOSE OF REVIEW: Postbiopsy infections (PBIs) are among the most common complications associated with transrectal ultrasound-guided prostate biopsy (TRUSPB). This article discusses the pathogenesis of TRUSPB-associated infectious complications and reviews the most recent findings on techniques to prevent PBIs. RECENT FINDINGS: Risk stratification is a powerful tool for identifying TRUSPB candidates whom warrant additional preventive measures. Bowel preparation with povidone-iodine-based enemas and needle disinfection with formalin solution are simple and attractive strategies, but their effectiveness needs to be thoroughly assessed...
April 24, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29685852/assessment-of-antimicrobiral-prophylaxis-in-transperineal-prostate-biopsy-a-single-center-retrospective-study-of-485-cases
#6
Kyoko Baba, Yoshitaka Sekine, Yoshiyuki Miyazawa, Takahiro Syuto, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
To verify the validity of our antimicrobial prophylaxis regimen for transperineal prostate biopsies, we investigated the rate of infectious complications in this procedure. We retrospectively investigated the infectious complications in 485 patients who underwent a transperineal prostate biopsy between 2014 and 2016 at our hospital. In the clinic, we use cefazolin (CEZ) for antimicrobial prophylaxis. Infectious complications were assessed up to postoperative day (POD) 30. Patients with infectious complications were further investigated to determine the site of infection, outbreak day, and type of pathogenic bacteria...
April 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29685613/cognitive-versus-software-assisted-registration-development-of-a-new-nomogram-predicting-prostate-cancer-at-mri-targeted-biopsies
#7
Sascha Kaufmann, Giorgio I Russo, Wolfgang Thaiss, Mike Notohamiprodjo, Fabian Bamberg, Jens Bedke, Giuseppe Morgia, Konstantin Nikolaou, Arnulf Stenzl, Stephan Kruck
INTRODUCTION: Multiparametric magnetic resonance imaging (mpMRI) is gaining acceptance to guide targeted biopsy (TB) in prostate cancer (PC) diagnosis. We aimed to compare the detection rate of software-assisted fusion TB (SA-TB) versus cognitive fusion TB (COG-TB) for PC and to evaluate potential clinical features in detecting PC and clinically significant PC (csPC) at TB. PATIENTS AND METHODS: This was a retrospective cohort study of patients with rising and/or persistently elevated prostate-specific antigen (PSA) undergoing mpMRI followed by either transperineal SA-TB or transrectal COG-TB...
April 3, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29679618/is-it-time-to-perform-only-mri-targeted-cores-our-experience-in-1032-men-submitted-to-prostate-biopsy
#8
Pietro Pepe, Antonio Garufi, Gian Domenico Priolo, Antonio Galia, Filippo Fraggetta, Michele Pennisi
PURPOSE: Diagnostic accuracy of mpMRI (multiparametric magnetic resonance imaging) in the diagnosis of clinically significant prostate cancer (csPCa) has been evaluated and compared with transperineal saturation prostate biopsy (SPBx). MATERIALS AND METHODS: From January 2011 to Febraury 2018 1032 men (median age 63 years) with median PSA of 8.6 ng/ml underwent repeat SPBx (reference test) for the suspicion of cancer. All the patients underwent 3.0 Tesla pelvic mpMRI before SPBx and the lesions with PI-RADS (Prostate Imaging-Reporting and Data System) score ≥ 3 were submitted to additional targeted fusion prostate biopsy (TPBx)...
April 18, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29679601/adoption-of-pre-biopsy-magnetic-resonance-imaging-for-men-undergoing-prostate-biopsy-in-the-united-states
#9
Wen Liu, Dattatraya Patil, David H Howard, Renee Moore, Heqiong Wang, Martin G Sanda, Christopher P Filson
OBJECTIVES: To assess adoption of pre-biopsy prostate MRI in the United States and evaluate factors associated with MRI-Bx use. Prior reports have shown improved cancer detection with magnetic resonance image-guided prostate biopsies (MRI-Bx) vs. transrectal ultrasound-guided methods (TRUS-Bx). Population-based trends of their use and outcomes have not been previously characterized. METHODS: Using private insurance claims (2009-2015), we identified men who underwent prostate biopsy...
April 18, 2018: Urology
https://www.readbyqxmd.com/read/29664243/new-technologies-and-techniques-for-prostate-cancer-focal-therapy-a-review-of-the-current-literature
#10
Estefanía Linares-Espinós, Arie Carneiro, Juan I Martínez-Salamanca, Fernando Bianco, Adalberto Castro-Alfaro, Xavier Cathelineau, Massimo Valerio, Rafael Sanchez-Salas
BACKGROUND: The aim of this study was to review the oncological and functional outcomes of new and established primary focal treatments (FT) for localized prostate cancer (PCa). METHODS: We performed a systematic search of published studies on FT for localized PCa using electronic databases (Medline and Embase). These studies included reports on hemiablation, focal ablation and target-ablation. We excluded salvage focal therapy studies and limited the search to those with a minimum of 12 months of follow-up...
April 16, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29661508/variability-in-the-multicentre-national-registry-in-active-surveillance-a-questionnaire-for-urologists
#11
J Rubio-Briones, A Borque-Fernando, L M Esteban-Escaño, S Martínez-Breijo, R Medina-López, V Hernández
BACKGROUND: Our main objective was to report the current use of active surveillance in Spain and to identify areas for potential improvement. METHODS: A questionnaire generated by the Platform for Multicentre Studies of the Spanish Urology Association (AEU/PIEM/2014/0001, NCT02865330) was sent to all associate researchers from January to March 2016. The questionnaire included 7 domains covering various aspects of active surveillance. RESULTS: Thirty-three of the 41 associate researchers responded to the questionnaire...
April 13, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29595039/an-update-on-prostate-biopsy-in-the-era-of-magnetic-resonance-imaging
#12
Antonio Cicione, Cosimo DE Nunzio, Stefano Manno, Rocco Damiano, Alessandro Posti, Estevao Lima, Andrea Tubaro, Filippo Balloni
INTRODUCTION: Prostate cancer (PCa) is a singular disease owing to absence of imaging technique able to detect suspicious glandular area at higher risk of disease. Nowadays, Magnetic Resonance Imaging (MRI) has been used as a way to detect PCa and simplify targeting prostate biopsy (PB). The aim of this study is to review the most recent data regarding prostate biopsy and MRI guided PB. EVIDENCE ACQUISITION: A comprehensive systematic MEDLINE search was performed in December 2017 for English language reports by using the following terms: prostate biopsy, multiparametric magnetic resonance imaging, prostate cancer, transrectal and transperineal ultrasound, target biopsy...
March 28, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29569311/initial-series-of-mri-fusion-targeted-prostate-biopsy-using-the-first-transperineal-targeted-platform-available-in-the-united-states
#13
Christopher D Kosarek, Ali M Mahmoud, Eduardo J Eyzaguirre, Yong Shan, Eric M Walser, Gary L Horn, Stephen B Williams
OBJECTIVES: To describe a step-by-step guide for using the first transperineal targeted prostate biopsy platform available in the United States. PATIENTS AND METHODS: A total of 32 men with elevated prostate specific antigen (PSA) diagnosed with a region of interest (ROI) on multiparametric magnetic resonance imaging (mpMRI) between February 2017 and January 2018. The procedure was accomplished transperineal accompanied by a stepper, combined with advanced mpMRI/TRUS fusion software to perform targeted prostate biopsy...
March 22, 2018: BJU International
https://www.readbyqxmd.com/read/29520850/exploring-the-oncoproteomic-response-of-human-prostate-cancer-to-therapeutic-radiation-using-data-independent-acquisition-dia-mass-spectrometry
#14
Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Ygal Haupt, Scott G Williams
INTRODUCTION: The development of radioresistance in prostate cancer (PCa) is an important clinical issue and is still largely uninformed by personalized molecular characteristics. The aim of this study was to establish a platform that describes the early oncoproteomic response of human prostate tissue to radiation therapy (RT) using a prospective human tissue cohort. METHODS: Fresh and fixed transperineal biopsies from eight men with clinically localized tumors were taken prior to and 14 days following a single fraction of high-dose-rate brachytherapy...
June 2018: Prostate
https://www.readbyqxmd.com/read/29510957/ideal-2a-phase-ii-study-of-ultrafocal-brachytherapy-for-low-and-intermediate-risk-prostate-cancer
#15
Pierre Graff, Daniel Portalez, Amélie Lusque, Thomas Brun, Richard Aziza, Jonathan Khalifa, Mathieu Roumiguié, Marie-Laure Quintyn Ranty, Thomas Filleron, Jean-Marc Bachaud, Bernard Malavaud
PURPOSE: Focal therapy of prostate cancer requires precise positioning of therapeutic agents within well-characterized index tumors (ITs). We assessed the feasibility of low-dose-rate ultrafocal brachytherapy. METHODS AND MATERIALS: The present study was an institutional review board-approved European Clinical Trials Database-registered phase II protocol. Patients referred (October 2013 to August 2016) for active surveillance (prostate-specific antigen <10 ng/mL, cT1c-cT2a, Gleason score on referring biopsy specimens ≤6 (3+3), ≤3 positive biopsy cores, ≤50% of cancer) were preselected...
February 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29501018/combined-laparoscopic-abdomino-endoscopic-perineal-total-mesorectal-excision-for-anorectal-malignant-melanoma-a-case-report
#16
Ryo Ohta, Takahiro Inoue, Manabu Goto, Yuji Tachimori, Koji Sekikawa
INTRODUCTION: This report presents a case of anorectal malignant melanoma treated with combined laparoscopic abdomino-endoscopic perineal total mesorectal excision. PRESENTATION OF CASE: An 82-year-old female presented with hematochezia. Colonoscopy revealed a 5-cm tumor in the anorectal junction, and biopsy specimen showed malignant melanoma. Modified ransanal total mesorectal excision was performed to get the sufficient surgical resection margins. After lymph node dissection in usual manner, mobilizing the rectum to the level of levator ani muscle...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29477717/a-single-centre-evaluation-of-the-diagnostic-accuracy-of-multiparametric-mri-against-transperineal-prostate-mapping-biopsy-an-analysis-of-men-with-bengin-histology-and-insignificant-cancer-following-trus-biopsy
#17
Raj P Pal, Ros Ahmad, Shaun Trecartan, James Voss, Shaista Ahmed, Alvaro Bazo, Jon Lloyd, Thomas J Walton
OBJECTIVES: This study evaluated the diagnostic performance of Transrectal-ultrasound guided biopsy (TRUSB) and Multiparametric MRI (mpMRI) in detecting prostate cancer (CaP) against Transperineal prostate mapping biopsy (TPM) as the reference test. METHODS: Between April 2012 and January 2016 426 patients underwent TRUS biopsy, mpMRI and TPM. Patients initially underwent systematic 12 core TRUSB, followed 3 months later by mpMRI (1.5T, high resolution T2 images, DWI, DCE)...
February 22, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29474846/diagnostic-accuracy-of-multiparametric-magnetic-resonance-imaging-and-fusion-guided-targeted-biopsy-evaluated-by-transperineal-template-saturation-prostate-biopsy-for-the-detection-and-characterization-of-prostate-cancer
#18
Ashkan Mortezavi, Olivia Märzendorfer, Olivio F Donati, Gianluca Rizzi, Niels J Rupp, Marian S Wettstein, Oliver Gross, Tullio Sulser, Thomas Hermanns, Daniel Eberli
PURPOSE: We evaluated the diagnostic accuracy of multiparametric magnetic resonance imaging and multiparametric magnetic resonance imaging/transrectal ultrasound fusion guided targeted biopsy against that of transperineal template saturation prostate biopsy to detect prostate cancer. MATERIALS AND METHODS: We retrospectively analyzed the records of 415 men who consecutively presented for prostate biopsy between November 2014 and September 2016 at our tertiary care center...
February 21, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29469937/radiomic-features-on-mri-enable-risk-categorization-of-prostate-cancer-patients-on-active-surveillance-preliminary-findings
#19
Ahmad Algohary, Satish Viswanath, Rakesh Shiradkar, Soumya Ghose, Shivani Pahwa, Daniel Moses, Ivan Jambor, Ronald Shnier, Maret Böhm, Anne-Maree Haynes, Phillip Brenner, Warick Delprado, James Thompson, Marley Pulbrock, Andrei S Purysko, Sadhna Verma, Lee Ponsky, Phillip Stricker, Anant Madabhushi
BACKGROUND: Radiomic analysis is defined as computationally extracting features from radiographic images for quantitatively characterizing disease patterns. There has been recent interest in examining the use of MRI for identifying prostate cancer (PCa) aggressiveness in patients on active surveillance (AS). PURPOSE: To evaluate the performance of MRI-based radiomic features in identifying the presence or absence of clinically significant PCa in AS patients. STUDY TYPE: Retrospective...
February 22, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29443386/technical-note-error-metrics-for-estimating-the-accuracy-of-needle-instrument-placement-during-transperineal-magnetic-resonance-ultrasound-guided-prostate-interventions
#20
Ester Bonmati, Yipeng Hu, Barbara Villarini, Rachael Rodell, Paul Martin, Lianghao Han, Ian Donaldson, Hashim U Ahmed, Caroline M Moore, Mark Emberton, Dean C Barratt
PURPOSE: Image-guided systems that fuse magnetic resonance imaging (MRI) with three-dimensional (3D) ultrasound (US) images for performing targeted prostate needle biopsy and minimally invasive treatments for prostate cancer are of increasing clinical interest. To date, a wide range of different accuracy estimation procedures and error metrics have been reported, which makes comparing the performance of different systems difficult. METHODS: A set of nine measures are presented to assess the accuracy of MRI-US image registration, needle positioning, needle guidance, and overall system error, with the aim of providing a methodology for estimating the accuracy of instrument placement using a MR/US-guided transperineal approach...
April 2018: Medical Physics
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