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Transperineal biopsy

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https://www.readbyqxmd.com/read/28073197/detection-rate-for-significant-cancer-at-confirmatory-biopsy-in-men-enrolled-in-active-surveillance-protocol-20-cores-vs-30-cores-vs-mri-trus-fusion-prostate-biopsy
#1
Pietro Pepe, Sebastiano Cimino, Antonio Garufi, Giandomenico Priolo, Giorgio Ivan Russo, Raimondo Giardina, Giulio Reale, Michele Barbera, Paolo Panella, Michele Pennisi, Giuseppe Morgia
INTRODUCTION: The detection rate for significant prostate cancer of extended vs saturation vs mMRI/TRUS fusion biopsy was prospectively evaluated in men enrolled in active surveillance (AS) protocol. Mterials and methods: From May 2013 to September 2016 75 men aged 66 years (median) with very low risk PCa were enrolled in an AS protocol and elegible criteria were: life expectancy greater than 10 years, cT1C, PSA below 10 ng/ml, PSA density < 0.20, 2 < unilateral positive biopsy cores, Gleason score (GS) equal to 6, greatest percentage of cancer (GPC) in a core < 50%...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28009149/robotic-assisted-laparoscopic-radical-prostatectomy-following-transrectal-compared-to-transperineal-prostate-biopsy-surgical-oncological-and-functional-outcomes
#2
Karan Wadhwa, Giulio Patruno, Andrew Patterson, Tristan Barrett, Chandni Dalia, Brendan C Koo, Ferdia A Gallagher, Eva Serrao, Anne Warren, Vincent Gnanapragasam, Nimish Shah, Andrew Doble, Christof Kastner
BACKGROUND: To assess if transperineal prostate (TP) biopsy affects th e outcome of robotic-assisted laparoscopic prostatectomy (RALP), with particular reference to perioperative complications, oncological results and functional outcomes in the early postoperative setting. METHODS: We identified 61 men who had undergone RALP after TP biopsies, from June 2012 to June 2014 and a control group of 120 men who had undergone RALP after conventional TRUS biopsy in the same period...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28007492/prostate-biopsy-related-infection-a-systematic-review-of-risk-factors-prevention-strategies-and-management-approaches
#3
REVIEW
Matthew J Roberts, Harrison Y Bennett, Patrick N Harris, Michael Holmes, Jeremy Grummet, Kurt Naber, Florian M E Wagenlehner
A systematic review to identify risk factors for prostate biopsy-related infection, preventative strategies and optimal management of infectious complications was conducted. Significant risk factors for post biopsy infection include urogenital infection, antibiotic use, international travel, hospital exposure, bacteriuria, previous transrectal biopsy and resistance of faecal flora to antibiotic prophylaxis (especially fluoroquinolones). Patients at risk may benefit from an adjusted biopsy protocol comprising transrectal biopsy under targeted prophylaxis, and/or the use of rectal disinfection techniques or using a transperineal approach...
December 19, 2016: Urology
https://www.readbyqxmd.com/read/28005230/comparison-of-free-hand-transperineal-mpmri-trus-fusion-guided-biopsy-with-transperineal-12-core-systematic-biopsy-for-the-diagnosis-of-prostate-cancer-a-single-center-prospective-study-in-china
#4
Qing Zhang, Wei Wang, Bing Zhang, Jong Shi, Yao Fu, Danyan Li, Suhan Guo, Shengjie Zhang, Haifeng Huang, Xuping Jiang, Weimin Zhou, Hongqian Guo
OBJECTIVES: To prospectively compare biopsy outcomes between free-hand transperineal mpMRI/TRUS fusion targeted biopsy (TB) and transperineal systematic biopsy (SB) in patients with first prostate biopsy. PATIENTS AND METHODS: In all, 224 consecutive patients with the suspicion of PCa were investigated. All patients were evaluated by 3.0-T mpMRI applying the ESUR criteria. All patients underwent free-hand transperineal mpMRI/TRUS fusion TB and additionally a transperineal SB...
December 22, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27995114/gleason-group-concordance-between-biopsy-and-radical-prostatectomy-specimens-a-cohort-study-from-prostate-cancer-outcome-registry-victoria
#5
Sue M Evans, Varuni Patabendi Bandarage, Caroline Kronborg, Arul Earnest, Jeremy Millar, David Clouston
BACKGROUND: A new prostate cancer (PCa) prognostic grading system [Gleason groups (GGs)] has been proposed based on the contemporary Gleason scores (GSs), which has five simplified prognostic categories. The objective of this study was to evaluate the agreement between the GGs of prostate biopsy and radical prostatectomy specimens and to identify predictive factors for upgrading GGs. METHODS: A total of 5339 cases of RP notified to the Prostate Cancer Outcomes Registry, Victoria, Australia over 6 years (2009-2014) from 46 hospitals, were included...
December 2016: Prostate International
https://www.readbyqxmd.com/read/27990424/diagnostic-accuracy-of-robot-guided-software-based-transperineal-mri-trus-fusion-biopsy-of-the-prostate-in-a-high-risk-population-of-previously-biopsy-negative-men
#6
Malte Kroenig, Kathrin Schaal, Matthias Benndorf, Martin Soschynski, Philipp Lenz, Tobias Krauss, Vanessa Drendel, Gian Kayser, Philipp Kurz, Martin Werner, Ulrich Wetterauer, Wolfgang Schultze-Seemann, Mathias Langer, Cordula A Jilg
Objective. In this study, we compared prostate cancer detection rates between MRI-TRUS fusion targeted and systematic biopsies using a robot-guided, software based transperineal approach. Methods and Patients. 52 patients received a MRIT/TRUS fusion followed by a systematic volume adapted biopsy using the same robot-guided transperineal approach. The primary outcome was the detection rate of clinically significant disease (Gleason grade ≥ 4). Secondary outcomes were detection rate of all cancers, sampling efficiency and utility, and serious adverse event rate...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27987032/zero-hospital-admissions-for-infection-after-577-transperineal-prostate-biopsies-using-single-dose-cephazolin-prophylaxis
#7
Lana Pepdjonovic, Guan Hee Tan, Sean Huang, Sarah Mann, Mark Frydenberg, Daniel Moon, Uri Hanegbi, Adam Landau, Ross Snow, Jeremy Grummet
PURPOSE: To determine the rate of hospital admissions for infection after transperineal biopsy of prostate (TPB) with single-dose cephazolin prophylaxis using a prospective database. METHOD: Between April 2013 and February 2016, 577 patients undergoing TPB had 2 g of cephazolin given intravenously at induction of anaesthesia. Data collected from these patients included age, PSA, prostate volume, number of cores taken and post-operative complications. RESULTS: No patients were readmitted to hospital with infection post-TPB...
December 16, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27955940/magnetic-resonance-imaging-transrectal-ultrasound-fusion-focal-cryotherapy-of-the-prostate-a-prospective-development-study
#8
Massimo Valerio, Taimur Tariq Shah, Paras Shah, Neil Mccartan, Mark Emberton, Manit Arya, Hashim Uddin Ahmed
OBJECTIVES: The use of software-based magnetic resonance-transrectal ultrasound fusion to deliver focal therapy may increase the precision of treatment. This is a prospective development study assessing the feasibility of Magnetic resonance imaging-transrectal ultrasound (MRI-TRUS) fusion focal cryotherapy. METHODS AND MATERIALS: Consecutive patients undergoing focal cryotherapy were included in an academic registry (December 2013-June 2014). MRI-TRUS fusion focal cryotherapy was offered to men with visible clinically significant prostate cancer (Galil SeedNet system)...
December 7, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27919653/transperineal-biopsies-of-mri-detected-aggressive-index-lesions-in-low-%C3%A2-and-intermediate-risk-prostate-cancer-patients-implications-for-treatment-decision
#9
A Gomez-Iturriaga, F Casquero, J I Lopez, A Urresola, A Ezquerro, D Buscher, P Bilbao, J Crook
PURPOSE: Multiparametric MRI (mpMRI) has a potential role for the identification of aggressive cancer that can be targeted for biopsy. We report the incidence and severity of discordant information between the pathology found on the transrectal ultrasound (TRUS)-guided biopsy and the mpMRI findings in patients with favorable or intermediate-risk prostate cancer referred for brachytherapy. METHODS AND MATERIALS: From March 2014 to September 2015, 10/44 consecutive patients with low- or intermediate-risk prostate cancer referred for brachytherapy presented an aggressive lesion on mpMRI and underwent an MRI-TRUS fusion-guided transperineal biopsy of the index lesion...
December 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27906722/location-and-grade-of-prostate-cancer-diagnosed-by-transperineal-template-guided-mapping-biopsy-after-negative-transrectal-ultrasound-guided-biopsy
#10
Nathan Bittner, Gregory Merrick, Al Taira, Abbey Bennett, Amy Schattel, Wayne Butler, Robert Galbreath, Edward Adamovich
OBJECTIVES: To determine the location and grade of prostate cancer diagnosed by transperineal template-guided mapping (TTMB) after negative transrectal ultrasound-guided (TRUS) biopsy. MATERIALS AND METHODS: This analysis consisted of 1118 consecutive patients who underwent TTMB from January 2005 to August 2015. Eight hundred thirty-five underwent TTMB after at least 1 negative TRUS biopsy and 283 underwent TTMB as the first biopsy procedure. The study population was divided into cohorts based on the number of prior TRUS biopsy sessions (0, 1, 2, and ≥3)...
November 30, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27900453/incidence-grade-and-distribution-of-prostate-cancer-following-transperineal-template-guided-mapping-biopsy-in-patients-with-atypical-small-acinar-proliferation
#11
Gregory S Merrick, Robert W Galbreath, Abbey Bennett, Wayne M Butler, Edward Amamovich
PURPOSE: To evaluate the role of transperineal template-guided mapping biopsy (TTMB) in patients with atypical small acinar proliferation (ASAP) diagnosed via transrectal ultrasound-guided needle biopsy (TRUS). METHODS: In total, 132 consecutive patients with TRUS-diagnosed ASAP underwent TTMB by means of an anatomic-based technique with sampling of 24 biopsy regions. For each of the 24 regions, 1-3 biopsy cores were obtained (depending on prostate size). No patient underwent pre-biopsy MRI imaging...
November 29, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27862869/multicentre-evaluation-of-targeted-and-systematic-biopsies-using-magnetic-resonance-and-ultrasound-image-fusion-guided-transperineal-prostate-biopsy-in-patients-with-a-previous-negative-biopsy
#12
Nienke L Hansen, Claudia Kesch, Tristan Barrett, Brendan Koo, Jan P Radtke, David Bonekamp, Heinz-Peter Schlemmer, Anne Y Warren, Kathrin Wieczorek, Markus Hohenfellner, Christof Kastner, Boris Hadaschik
OBJECTIVES: To evaluate the detection rates of targeted and systematic biopsies in magnetic resonance imaging (MRI) and ultrasound (US) image-fusion transperineal prostate biopsy for patients with previous benign transrectal biopsies in two high-volume centres. PATIENTS AND METHODS: A two centre prospective outcome study of 487 patients with previous benign biopsies that underwent transperineal MRI/US fusion-guided targeted and systematic saturation biopsy from 2012 to 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27859637/assessing-clinically-significant-prostate-cancer-diagnostic-properties-of-multiparametric-magnetic-resonance-imaging-compared-to-three-dimensional-transperineal-template-mapping-histopathology
#13
Matvey Tsivian, Rajan T Gupta, Efrat Tsivian, Peter Qi, Melissa H Mendez, Michael R Abern, Kae Jack Tay, Thomas J Polascik
OBJECTIVE: To evaluate the diagnostic properties of multiparametric magnetic resonance imaging in the detection, localization and characterization of prostate cancer using three-dimensional transperineal template mapping biopsy histopathology as the comparator. METHODS: A retrospective analysis of patients undergoing prostate multiparametric magnetic resonance imaging followed by three-dimensional transperineal template mapping biopsy was carried out. For imaging and pathology data, the prostate was divided in octants with the urethra being the midline...
November 8, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27856226/indications-utilization-and-complications-following-prostate-biopsy-a-new-york-state-analysis
#14
Joshua A Halpern, Art Sedrakyan, Brian Dinerman, Wei-Chun Hsu, Jialin Mao, Jim C Hu
PURPOSE: Uptake of active surveillance and changes in prostate cancer care may affect utilization of and complications following prostate needle biopsy (PNBx). We characterized recent trends and risk factors for PNBx complications using a statewide, all-payer cohort. MATERIALS AND METHODS: We utilized the New York Statewide Planning and Research Cooperation System (SPARCS) to identify PNBx performed between 2011 and 2014 via transrectal (N=9472) and transperineal (N=421) approach...
November 14, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27855661/comparison-of-the-complications-of-traditional-12-cores-transrectal-prostate-biopsy-with-image-fusion-guided-transperineal-prostate-biopsy
#15
Haifeng Huang, Wei Wang, Tingsheng Lin, Qing Zhang, Xiaozhi Zhao, Huibo Lian, Hongqian Guo
BACKGROUND: To compare the complications of traditional transrectal (TR) prostate biopsy and image fusion guided transperineal (TP) prostate biopsy in our center. METHODS: Two hundred and fourty-two patients who underwent prostate biopsy from August 2014 to January 2015were reviewed. Among them, 144 patients underwent systematic 12-core transrectal ultrasonography (TRUS) guided prostate biopsy (TR approach) while 98 patients underwent free-hand transperineal targeted biopsy with TRUS and multi-parameter magnetic resonance imaging (mpMRI) fusion images (TP approach)...
November 17, 2016: BMC Urology
https://www.readbyqxmd.com/read/27847972/first-report-of-robot-assisted-transperineal-fusion-versus-off-target-biopsy-in-patients-undergoing-repeat-prostate-biopsy
#16
S Kaufmann, J Mischinger, B Amend, S Rausch, M Adam, M Scharpf, F Fend, U Kramer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
PURPOSE: To clarify the value of targeted versus off-target biopsies in men with a suspicion of prostate cancer (PC) and a visible lesion in multi-parametric magnetic resonance imaging (mpMRI) using transperineal robot-assisted biopsy. METHODS: Fifty-five consecutive men with one non-palpable suspicious lesion in mpMRI after negative 12-core transrectal ultrasound-guided biopsy were enrolled in 2014-2015. Lesions were scored using the Prostate Imaging Reporting and Data System...
November 15, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27830373/precision-of-mri-ultrasound-fusion-biopsy-in-prostate-cancer-diagnosis-an-ex-vivo-comparison-of-alternative-biopsy-techniques-on-prostate-phantoms
#17
N Westhoff, F P Siegel, D Hausmann, M Polednik, J von Hardenberg, M S Michel, M Ritter
PURPOSE: Comparing the accuracy of MRI/ultrasound-guided target-biopsy by transrectal biopsy (TRB) with elastic versus rigid image fusion versus transperineal biopsy (TPB) with rigid image fusion in a standardized setting. METHODS: Target-biopsy of six differently sized and located lesions was performed on customized CIRS 070L prostate phantoms. Lesions were only MRI-visible. After prior MRI for lesion location, one targeted biopsy per lesion was obtained by TRB with elastic image fusion with Artemis™ (Eigen, USA), TRB with rigid image fusion with real-time virtual sonography (Hitachi, Japan) and TPB with rigid image fusion with a brachytherapy approach (Elekta, Sweden), each on a phantom of 50, 100 and 150 ml prostate volume...
November 9, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27814981/hemi-gland-focal-low-dose-rate-prostate-brachytherapy-an-analysis-of-dosimetric-outcomes
#18
Robert Laing, Adrian Franklin, Jennifer Uribe, Alex Horton, Santiago Uribe-Lewis, Stephen Langley
BACKGROUND AND PURPOSE: Advances in magnetic resonance imaging (MRI) and prostate sampling enable early identification of men with low to intermediate risk prostate cancer who are candidates for focal therapies that minimise side effects. We report dosimetry data from a pilot study evaluating the effectiveness of hemi-gland low dose rate (HG-LDR) brachytherapy as a focal therapy approach to control unilateral localised disease. MATERIAL AND METHODS: Twenty-two men underwent HG-LDR brachytherapy...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27778089/comparison-of-initial-and-tertiary-centre-second-opinion-reads-of-multiparametric-magnetic-resonance-imaging-of-the-prostate-prior-to-repeat-biopsy
#19
Nienke L Hansen, Brendan C Koo, Ferdia A Gallagher, Anne Y Warren, Andrew Doble, Vincent Gnanapragasam, Ola Bratt, Christof Kastner, Tristan Barrett
OBJECTIVES: To investigate the value of second-opinion evaluation of multiparametric prostate magnetic resonance imaging (MRI) by subspecialised uroradiologists at a tertiary centre for the detection of significant cancer in transperineal fusion prostate biopsy. METHODS: Evaluation of prospectively acquired initial and second-opinion radiology reports of 158 patients who underwent MRI at regional hospitals prior to transperineal MR/untrasound fusion biopsy at a tertiary referral centre over a 3-year period...
October 24, 2016: European Radiology
https://www.readbyqxmd.com/read/27760001/geometric-systematic-prostate-biopsy
#20
Doyoung Chang, Xue Chong, Chunwoo Kim, Changhan Jun, Doru Petrisor, Misop Han, Dan Stoianovici
OBJECTIVE: The common sextant prostate biopsy schema lacks a three-dimensional (3D) geometric definition. The study objective was to determine the influence of the geometric distribution of the cores on the detection probability of prostate cancer (PCa). METHODS: The detection probability of significant (>0.5cm(3)) and insignificant (<0.2cm(3)) tumors was quantified based on a novel 3D capsule model of the biopsy sample. The geometric distribution of the cores was optimized to maximize the probability of detecting significant cancer for various prostate sizes (20 to 100cm(3)), number of biopsy cores (6 to 40 cores) and biopsy core lengths (14 to 40mm) for transrectal and transperineal biopsies...
October 19, 2016: Minimally Invasive Therapy & Allied Technologies: MITAT
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