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Transperineal biopsy

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https://www.readbyqxmd.com/read/27919653/transperineal-biopsies-of-mri-detected-aggressive-index-lesions-in-low-%C3%A2-and-intermediate-risk-prostate-cancer-patients-implications-for-treatment-decision
#1
A Gomez-Iturriaga, F Casquero, J I Lopez, A Urresola, A Ezquerro, D Buscher, P Bilbao, J Crook
PURPOSE: Multiparametric MRI (mpMRI) has a potential role for the identification of aggressive cancer that can be targeted for biopsy. We report the incidence and severity of discordant information between the pathology found on the transrectal ultrasound (TRUS)-guided biopsy and the mpMRI findings in patients with favorable or intermediate-risk prostate cancer referred for brachytherapy. METHODS AND MATERIALS: From March 2014 to September 2015, 10/44 consecutive patients with low- or intermediate-risk prostate cancer referred for brachytherapy presented an aggressive lesion on mpMRI and underwent an MRI-TRUS fusion-guided transperineal biopsy of the index lesion...
December 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27906722/location-and-grade-of-prostate-cancer-diagnosed-by-transperineal-template-guided-mapping-biopsy-after-negative-transrectal-ultrasound-guided-biopsy
#2
Nathan Bittner, Gregory Merrick, Al Taira, Abbey Bennett, Amy Schattel, Wayne Butler, Robert Galbreath, Edward Adamovich
OBJECTIVES: To determine the location and grade of prostate cancer diagnosed by transperineal template-guided mapping (TTMB) after negative transrectal ultrasound-guided (TRUS) biopsy. MATERIALS AND METHODS: This analysis consisted of 1118 consecutive patients who underwent TTMB from January 2005 to August 2015. Eight hundred thirty-five underwent TTMB after at least 1 negative TRUS biopsy and 283 underwent TTMB as the first biopsy procedure. The study population was divided into cohorts based on the number of prior TRUS biopsy sessions (0, 1, 2, and ≥3)...
November 30, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27900453/incidence-grade-and-distribution-of-prostate-cancer-following-transperineal-template-guided-mapping-biopsy-in-patients-with-atypical-small-acinar-proliferation
#3
Gregory S Merrick, Robert W Galbreath, Abbey Bennett, Wayne M Butler, Edward Amamovich
PURPOSE: To evaluate the role of transperineal template-guided mapping biopsy (TTMB) in patients with atypical small acinar proliferation (ASAP) diagnosed via transrectal ultrasound-guided needle biopsy (TRUS). METHODS: In total, 132 consecutive patients with TRUS-diagnosed ASAP underwent TTMB by means of an anatomic-based technique with sampling of 24 biopsy regions. For each of the 24 regions, 1-3 biopsy cores were obtained (depending on prostate size). No patient underwent pre-biopsy MRI imaging...
November 29, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27862869/multicentre-evaluation-of-target-and-systematic-biopsies-using-magnetic-resonance-and-ultrasound-image-fusion-guided-transperineal-prostate-biopsy-in-patients-with-a-previous-negative-biopsy
#4
N L Hansen, C Kesch, T Barrett, B Koo, J P Radtke, D Bonekamp, H P Schlemmer, A Y Warren, K Wieczorek, M Hohenfellner, C Kastner, B Hadaschik
OBJECTIVES: To evaluate the detection rates of targeted and systematic biopsies in magnetic resonance (MRI) and transrectal ultrasound (US) image-fusion transperineal prostate biopsy for patients with previous benign transrectal US guided biopsies in two high-volume centres. PATIENTS AND METHODS: Two centre, prospective outcome study of 487 patients with previous benign biopsies that underwent transperineal MRI/US fusion-guided target and systematic saturation biopsy from 2012 to 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27859637/assessing-clinically-significant-prostate-cancer-diagnostic-properties-of-multiparametric-magnetic-resonance-imaging-compared-to-three-dimensional-transperineal-template-mapping-histopathology
#5
Matvey Tsivian, Rajan T Gupta, Efrat Tsivian, Peter Qi, Melissa H Mendez, Michael R Abern, Kae Jack Tay, Thomas J Polascik
OBJECTIVE: To evaluate the diagnostic properties of multiparametric magnetic resonance imaging in the detection, localization and characterization of prostate cancer using three-dimensional transperineal template mapping biopsy histopathology as the comparator. METHODS: A retrospective analysis of patients undergoing prostate multiparametric magnetic resonance imaging followed by three-dimensional transperineal template mapping biopsy was carried out. For imaging and pathology data, the prostate was divided in octants with the urethra being the midline...
November 8, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27856226/indications-utilization-and-complications-following-prostate-biopsy-a-new-york-state-analysis
#6
Joshua A Halpern, Art Sedrakyan, Brian Dinerman, Wei-Chun Hsu, Jialin Mao, Jim C Hu
PURPOSE: Uptake of active surveillance and changes in prostate cancer care may affect utilization of and complications following prostate needle biopsy (PNBx). We characterized recent trends and risk factors for PNBx complications using a statewide, all-payer cohort. MATERIALS AND METHODS: We utilized the New York Statewide Planning and Research Cooperation System (SPARCS) to identify PNBx performed between 2011 and 2014 via transrectal (N=9472) and transperineal (N=421) approach...
November 14, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27855661/comparison-of-the-complications-of-traditional-12-cores-transrectal-prostate-biopsy-with-image-fusion-guided-transperineal-prostate-biopsy
#7
Haifeng Huang, Wei Wang, Tingsheng Lin, Qing Zhang, Xiaozhi Zhao, Huibo Lian, Hongqian Guo
BACKGROUND: To compare the complications of traditional transrectal (TR) prostate biopsy and image fusion guided transperineal (TP) prostate biopsy in our center. METHODS: Two hundred and fourty-two patients who underwent prostate biopsy from August 2014 to January 2015were reviewed. Among them, 144 patients underwent systematic 12-core transrectal ultrasonography (TRUS) guided prostate biopsy (TR approach) while 98 patients underwent free-hand transperineal targeted biopsy with TRUS and multi-parameter magnetic resonance imaging (mpMRI) fusion images (TP approach)...
November 17, 2016: BMC Urology
https://www.readbyqxmd.com/read/27847972/first-report-of-robot-assisted-transperineal-fusion-versus-off-target-biopsy-in-patients-undergoing-repeat-prostate-biopsy
#8
S Kaufmann, J Mischinger, B Amend, S Rausch, M Adam, M Scharpf, F Fend, U Kramer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
PURPOSE: To clarify the value of targeted versus off-target biopsies in men with a suspicion of prostate cancer (PC) and a visible lesion in multi-parametric magnetic resonance imaging (mpMRI) using transperineal robot-assisted biopsy. METHODS: Fifty-five consecutive men with one non-palpable suspicious lesion in mpMRI after negative 12-core transrectal ultrasound-guided biopsy were enrolled in 2014-2015. Lesions were scored using the Prostate Imaging Reporting and Data System...
November 15, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27830373/precision-of-mri-ultrasound-fusion-biopsy-in-prostate-cancer-diagnosis-an-ex-vivo-comparison-of-alternative-biopsy-techniques-on-prostate-phantoms
#9
N Westhoff, F P Siegel, D Hausmann, M Polednik, J von Hardenberg, M S Michel, M Ritter
PURPOSE: Comparing the accuracy of MRI/ultrasound-guided target-biopsy by transrectal biopsy (TRB) with elastic versus rigid image fusion versus transperineal biopsy (TPB) with rigid image fusion in a standardized setting. METHODS: Target-biopsy of six differently sized and located lesions was performed on customized CIRS 070L prostate phantoms. Lesions were only MRI-visible. After prior MRI for lesion location, one targeted biopsy per lesion was obtained by TRB with elastic image fusion with Artemis™ (Eigen, USA), TRB with rigid image fusion with real-time virtual sonography (Hitachi, Japan) and TPB with rigid image fusion with a brachytherapy approach (Elekta, Sweden), each on a phantom of 50, 100 and 150 ml prostate volume...
November 9, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27814981/hemi-gland-focal-low-dose-rate-prostate-brachytherapy-an-analysis-of-dosimetric-outcomes
#10
Robert Laing, Adrian Franklin, Jennifer Uribe, Alex Horton, Santiago Uribe-Lewis, Stephen Langley
BACKGROUND AND PURPOSE: Advances in magnetic resonance imaging (MRI) and prostate sampling enable early identification of men with low to intermediate risk prostate cancer who are candidates for focal therapies that minimise side effects. We report dosimetry data from a pilot study evaluating the effectiveness of hemi-gland low dose rate (HG-LDR) brachytherapy as a focal therapy approach to control unilateral localised disease. MATERIAL AND METHODS: Twenty-two men underwent HG-LDR brachytherapy...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27778089/comparison-of-initial-and-tertiary-centre-second-opinion-reads-of-multiparametric-magnetic-resonance-imaging-of-the-prostate-prior-to-repeat-biopsy
#11
Nienke L Hansen, Brendan C Koo, Ferdia A Gallagher, Anne Y Warren, Andrew Doble, Vincent Gnanapragasam, Ola Bratt, Christof Kastner, Tristan Barrett
OBJECTIVES: To investigate the value of second-opinion evaluation of multiparametric prostate magnetic resonance imaging (MRI) by subspecialised uroradiologists at a tertiary centre for the detection of significant cancer in transperineal fusion prostate biopsy. METHODS: Evaluation of prospectively acquired initial and second-opinion radiology reports of 158 patients who underwent MRI at regional hospitals prior to transperineal MR/untrasound fusion biopsy at a tertiary referral centre over a 3-year period...
October 24, 2016: European Radiology
https://www.readbyqxmd.com/read/27760001/geometric-systematic-prostate-biopsy
#12
Doyoung Chang, Xue Chong, Chunwoo Kim, Changhan Jun, Doru Petrisor, Misop Han, Dan Stoianovici
OBJECTIVE: The common sextant prostate biopsy schema lacks a three-dimensional (3D) geometric definition. The study objective was to determine the influence of the geometric distribution of the cores on the detection probability of prostate cancer (PCa). METHODS: The detection probability of significant (>0.5cm(3)) and insignificant (<0.2cm(3)) tumors was quantified based on a novel 3D capsule model of the biopsy sample. The geometric distribution of the cores was optimized to maximize the probability of detecting significant cancer for various prostate sizes (20 to 100cm(3)), number of biopsy cores (6 to 40 cores) and biopsy core lengths (14 to 40mm) for transrectal and transperineal biopsies...
October 19, 2016: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/27748407/the-prostate-health-index-adds-predictive-value-to-multi-parametric-mri-in-detecting-significant-prostate-cancers-in-a-repeat-biopsy-population
#13
V J Gnanapragasam, K Burling, A George, S Stearn, A Warren, T Barrett, B Koo, F A Gallagher, A Doble, C Kastner, R A Parker
Both multi-parametric MRI (mpMRI) and the Prostate Health Index (PHI) have shown promise in predicting a positive biopsy in men with suspected prostate cancer. Here we investigated the value of combining both tests in men requiring a repeat biopsy. PHI scores were measured in men undergoing re-biopsy with an mpMRI image-guided transperineal approach (n = 279, 94 with negative mpMRIs). The PHI was assessed for ability to add value to mpMRI in predicting all or only significant cancers (Gleason ≥7). In this study adding PHI to mpMRI improved overall and significant cancer prediction (AUC 0...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27734428/the-use-of-transperineal-sector-biopsy-as-a-first-line-biopsy-strategy-a-multi-institutional-analysis-of-clinical-outcomes-and-complications
#14
David Eldred-Evans, Veeru Kasivisvanathan, Fahd Khan, Mieke Van Hemelrijck, Alexander Polson, Peter Acher, Richard Popert
PURPOSE: Systematic transrectal ultrasound biopsies have been the first-line biopsy strategy in men with suspected prostate cancer for over 30 years. Transperineal biopsy is an alternative approach but has been predominately reserved as a repeat biopsy strategy and not widely used as a first-line approach. This study evaluates the diagnostic and clinical outcomes of transperineal sector biopsy (TPSB) as a first-line biopsy strategy in the diagnosis and management of prostate cancer. MATERIALS AND METHODS: A multi-institutional review of 402 consecutive patients who underwent primary transperineal sector biopsy...
October 10, 2016: Urology Journal
https://www.readbyqxmd.com/read/27697580/nanoknife-electroporation-ablation-trial-a-prospective-development-study-investigating-focal-irreversible-electroporation-for-localized-prostate-cancer
#15
Massimo Valerio, Louise Dickinson, Afia Ali, Navin Ramachadran, Ian Donaldson, Neil Mccartan, Alex Freeman, Hashim U Ahmed, Mark Emberton
PURPOSE: Irreversible electroporation has attractive attributes for focal ablation, namely nonthermal effect, precise demarcation of treatment and tissue selectivity. We report a prospective development study investigating focal irreversible electroporation. MATERIALS AND METHODS: A total of 20 men with certain characteristics were recruited for study, including a visible index lesion on anterior magnetic resonance imaging that was concordant with transperineal targeted and template prostate mapping biopsy, absent clinically significant disease noted elsewhere (University College London definition 2) and prostate specific antigen 15 ng/ml or less...
September 30, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27681661/robotic-assisted-laparoscopic-radical-prostatectomy-following-transrectal-compared-to-transperineal-prostate-biopsy-surgical-oncological-and-functional-outcomes
#16
Karan Wadhwa, Giulio Patruno, Andrew Patterson, Tristan Barrett, Chandni Dalia, Brendan C Koo, Ferdia A Gallagher, Eva Serrao, Anne Warren, Vincent Gnanapragasam, Nimish Shah, Andrew Doble, Christof Kastner
BACKGROUND: To assess if transperineal prostate (TP) biopsy affects the outcome of robotic-assisted laparoscopic prostatectomy (RALP), with particular reference to peri-operative complications, oncological results and functional outcomes in the early post operative setting. METHODS: We identified 61 men who had undergone RALP after TP biopsies, from June 2012 to June 2014 and a control group of 120 men who had undergone RALP after conventional TRUS biopsy in the same period...
September 29, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27672001/clarifying-the-psa-grey-zone-the-management-of-patients-with-a-borderline-psa
#17
REVIEW
Talisa Ross, Kamran Ahmed, Nicholas Raison, Ben Challacombe, Prokar Dasgupta
INTRODUCTION: Prostate specific antigen is a marker for prostate cancer and a key diagnostic tool, yet when to refer patients with a borderline PSA is currently unclear. This review describes how to assess a patient with borderline PSA and provides an algorithm for management. METHODS: Current literature on reference values, factors affecting PSA, indications for referral, non-invasive investigations and the role of MRI were reviewed. Medline and EMBASE were searched using MeSH terms...
November 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27649108/predictive-role-of-trimprob-associated-with-multiparametric-mri-in-the-diagnosis-of-prostate-cancer
#18
Gustavo Cardoso Guimaraes, Walter Henriques da Costa, Renato Almeida Rosa, Stênio Zequi, Ricardo Favaretto
OBJECTIVES: To evaluate the predictive value of TRIMprob test to detect prostate cancer (PCa) in patients referred to prostate biopsy (PB). MATERIAL AND METHODS: Patients with PSA <10ng/mL and rectal exam without findings suggestive of prostate cancer were selected for TRIMprob evaluation. Exam was performed by a single operator through transperineal approach. Patients admitted for the study were submitted to TRIMprob and multiparametric mag¬netic resonance (mpMRI) and posteriorly to PB...
September 20, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27630313/comparison-between-a-combined-transrectal-and-transperineal-approach-and-a-transrectal-approach-for-prostate-rebiopsy
#19
Yohei Shida, Tomoaki Hakariya, Kosuke Takehara, Toru Onita, Yasuyoshi Miyata, Hideki Sakai
AIM: To evaluate whether a combination method involving the transrectal (TR) and transperineal (TP) approach can increase the cancer detection rate relative to the TR approach regarding repeat prostate biopsy. PATIENTS AND METHODS: One thousand and nineteen patients underwent initial prostate biopsies and 298 repeat prostate biopsies. All initial biopsies were conducted transrectally. Of the repeat biopsies, 179 (60.1%) were performed using the combined transrectal and transperineal (TR+TP) approach; 113 (37...
September 2016: Anticancer Research
https://www.readbyqxmd.com/read/27611962/-18-f-fech-pet-ct-to-assess-clinically-significant-disease-in-prostate-cancer-correlation-with-maximum-and-total-cancer-core-length-obtained-via-mri-guided-template-mapping-biopsies
#20
Athar Haroon, Hashim U Ahmed, Paul Cathcart, Ahmad Almuhaideb, Irfan Kayani, John Dickson, Alex Kirkham, Alex Freeman, Mark Emberton, Jamshed Bomanji
OBJECTIVE: The objective of this study was to detect clinically significant and insignificant prostate cancer on (18)F-fluoroethylcholine (FECH) PET/CT and to correlate findings with transperineal template-guided prostate mapping (TPM) biopsy. SUBJECTS AND METHODS: Fifty-six lobes of the prostate were analyzed in 28 men who underwent FECH PET/CT and TPM. Whole-body images and pelvic images were acquired at 60 and 90 minutes after tracer administration. FECH PET/CT findings were correlated with TPM...
December 2016: AJR. American Journal of Roentgenology
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