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Endoscopy Inflammatory bowel

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https://www.readbyqxmd.com/read/29449505/detection-of-crohn-disease-in-patients-with-spondyloarthropathy-the-space-capsule-study
#1
Uri Kopylov, Michael Starr, Craig Watts, Serge Dionne, Marc Girardin, Ernest G Seidman
OBJECTIVE: Inflammatory bowel disease (IBD) is generally reported to be associated with spondylarthropathies (SpA) in 5%-15% of cases. Systematic colonoscopic assessment by protocol demonstrated mucosal inflammation characteristic of Crohn disease (CD) in up to one-third of patients with SpA. Video capsule endoscopy (CE) is a superior diagnostic tool to detect small bowel mucosal disease. Our study compared the accuracy of CE to standard colonoscopy for detection of inflammatory bowel lesions in patients with SpA, and to describe predictors of small bowel inflammation (SBI) in this cohort...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29447487/perianal-crohn-s-disease-association-with-significant-inflammatory-activity-in-proximal-small-bowel-segments
#2
Sofia Xavier, Tiago Cúrdia Gonçalves, Francisca Dias de Castro, Joana Magalhães, Bruno Rosa, Maria João Moreira, José Cotter
OBJECTIVES: Perianal Crohn's disease (CD) prevalence varies according to the disease location, being particularly frequent in patients with colonic involvement. We aimed to evaluate small bowel involvement and compare small bowel capsule endoscopy findings and inflammatory activity between patients with and without perianal disease. MATERIALS AND METHODS: Retrospective single-center study including 71 patients - all patients with perianal CD (17 patients) who performed a small bowel capsule endoscopy were included, and non-perianal CD patients were randomly selected (54 patients)...
February 15, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29437914/gastrointestinal-ultrasound-in-inflammatory-bowel-disease-an-underused-resource-with-potential-paradigm-changing-application
#3
REVIEW
Robert Venning Bryant, Antony Friedman, Emily Kate Wright, Kirstin Taylor, Jakob Begun, Giovanni Maconi, Christian Maaser, Kerri L Novak, Torsten Kucharzik, Nathan S S Atkinson, Anil Asthana, Peter R Gibson
Evolution of treatment targets in IBD has increased the need for objective monitoring of disease activity to guide therapeutic strategy. Although mucosal healing is the current target of therapy in IBD, endoscopy is invasive, expensive and unappealing to patients. GI ultrasound (GIUS) represents a non-invasive modality to assess disease activity in IBD. It is accurate, cost-effective and reproducible. GIUS can be performed at the point of care without specific patient preparation so as to facilitate clinical decision-making...
February 3, 2018: Gut
https://www.readbyqxmd.com/read/29430322/monitoring-inflammatory-bowel-disease-during-pregnancy-current-literature-and-future-challenges
#4
REVIEW
Tenzin Choden, Rohan Mandaliya, Aline Charabaty, Mark C Mattar
Inflammatory bowel disease has a high prevalence in women of childbearing age and can have a significant impact on pregnancy, from conceiving to carrying the pregnancy. Active disease during pregnancy is known to have negative effects on pregnancy outcomes; therefore, careful monitoring during this period is an important but challenging aspect of care and is crucial as it affects important management decisions. Recent data seems to suggest that endoscopy is a relatively safe procedure during all trimesters of pregnancy...
February 6, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29411220/novel-therapies-and-treatment-strategies-for-patients-with-inflammatory-bowel-disease
#5
REVIEW
Marjolijn Duijvestein, Robert Battat, Niels Vande Casteele, Geert R D'Haens, William J Sandborn, Reena Khanna, Vipul Jairath, Brian G Feagan
PURPOSE OF REVIEW: This article reviews current treatment options and strategies and provides an update on the status of drug development programs of new therapeutic agents for inflammatory bowel diseases (IBD). RECENT FINDINGS: In the past two decades, tumor necrosis factor antagonist therapy has given clinicians better treatment options. However, not all patients respond to induction therapy with these agents, and of those initially responding, up to 40% ultimately lose response due to suboptimal drug exposure (e...
February 6, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29391089/abdominal-visceral-fat-area-and-chronic-pouchitis-after-ileal-pouch-anal-anastomosis
#6
Vivek Pandrangi, Daniel Mandel, Norman Gellada, Dionisio Mieses, Cindy Kallman, Karen Zaghiyan, Phillip Fleshner
Chronic pouchitis (CP) after ileal pouch-anal anastomosis is a significant clinical problem. Adipose tissues produce antiinflammatory cytokines and chemokines. We evaluated the association between abdominal visceral fat area (VFA) and CP. Patients with a preoperative CT evaluation were included. The diagnosis of CP was confirmed in all cases by endoscopy with afferent ileal limb intubation. Patients were allocated into groups of high VFA and low VFA. The study cohort of 52 patients had a median body mass index of 22 (range, 14-32)...
October 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29387321/fecal-calprotectin-level-in-patients-with-ibd-and-noninflammatory-disease-of-colon-a-study-in-babol-northern-iran
#7
Majid Sharbatdaran, Amin Holaku, Mehrdad Kashifard, Ali Bijani, Alireza Firozjahi, Akram Hosseini, Sepideh Siadati
Background: Inflammatory bowel disease (IBD) is a chronic disease with a relapsing course of inflammation in the digestive system. Endoscopy and histopathology are the golden standard methods for detection and assessment of IBD. A distinct increase of fecal calprotectin level can be a useful marker for the diagnosis of IBD. The aim of this study was to evaluate the fecal calprotectin level in patients with IBD and without inflammatory diseases of the colon. Methods: Calprotectin levels of patients referred to the Ayatollah Rouhani Hospital of Babol, northern Iran with clinical symptoms of colon disease were evaluated...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29385427/diagnostic-yield-of-dysplasia-in-polyp-adjacent-biopsies-for-patients-with-inflammatory-bowel-disease-a-cross-sectional-study
#8
Conor Lahiff, Lai Mun Wang, Simon P L Travis, James E East
Introduction: Patients with inflammatory bowel disease (IBD) undergoing polypectomy are recommended by current guidelines to have biopsies taken from adjacent mucosa to determine whether there is dysplasia present. With improvements in endoscopic imaging it is now possible to characterise colonic lesions with higher levels of confidence than previously. We reviewed the diagnostic yield of polyp-adjacent biopsies in IBD. Materials and Methods: A systematic search of our histopathology database revealed cases where polyps had been endoscopically resected or biopsied in patients with IBD...
January 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29384209/early-vedolizumab-trough-levels-predict-mucosal-healing-in-inflammatory-bowel-disease-a-multicentre-prospective-observational-study
#9
W Yacoub, N Williet, L Pouillon, T Di-Bernado, M De Carvalho Bittencourt, S Nancey, A Lopez, S Paul, C Zallot, X Roblin, L Peyrin-Biroulet
BACKGROUND: The correlation between vedolizumab trough levels during induction therapy and mucosal healing remains unknown. AIM: To compare early vedolizumab trough levels in patients with and without mucosal healing within the first year after treatment initiation. METHODS: We prospectively collected vedolizumab trough levels in all inflammatory bowel disease patients at weeks 2, 6 and 14 of vedolizumab treatment in three French referral centres between 1 June 2014 and 31 March 2017...
January 31, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29361106/disagreement-among-gastroenterologists-using-the-mayo-and-rutgeerts-endoscopic-scores
#10
Samuel Raimundo Fernandes, João Sebastião Lopes Dias Pinto, Pedro Marques da Costa, Luís Correia
Background: Endoscopy is routinely performed in patients with inflammatory bowel disease to evaluate disease severity and guide important clinical decisions. However, variability in the interpretation of endoscopic findings can significantly impact patient management. Methods: Fifty-eight gastroenterologists were invited to participate in an online survey including pictures and video recordings of colonoscopies performed in patients with ulcerative colitis (UC) and Crohn's disease (CD)...
January 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29361092/safety-clinical-response-and-microbiome-findings-following-fecal-microbiota-transplant-in-children-with-inflammatory-bowel-disease
#11
Alka Goyal, Andrew Yeh, Brian R Bush, Brian A Firek, Leah M Siebold, Matthew Brian Rogers, Adam D Kufen, Michael J Morowitz
Background: The role of fecal microbiota transplant (FMT) in the treatment of pediatric inflammatory bowel disease (IBD) is unknown. The aims of this study were to assess safety, clinical response, and gut microbiome alterations in children with Crohn's disease (CD), ulcerative colitis (UC), or indeterminate colitis (IC). Methods: In this open-label, single-center prospective trial, patients with IBD refractory to medical therapy underwent a single FMT by upper and lower endoscopy...
January 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29360261/advanced-endoscopic-imaging-for-diagnosis-of-ibd-present-and-future-perspectives
#12
REVIEW
Visvakanth Sivanathan, Gian Eugenio Tontini, Markus Möhler, Peter R Galle, Helmut Neumann
Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) causing severe damage of the luminal gastrointestinal tract. Differential diagnosis between both disease entities is sometimes awkward requiring a multifactorial pathway, including clinical and laboratory data, radiological findings, histopathology and endoscopy. Apart from disease diagnosis, endoscopy in IBD plays a major role for prediction of disease severity and extent (i.e. mucosal healing) for tailored patient management and for screening of colitis associated cancer and its precursor lesions...
January 23, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29359823/detection-and-characterization-of-colitis-associated-cancer-dysplasia-based-on-reports-from-the-jddw2017-and-meta-analyses-of-prospective-studies-concerning-endoscopic-procedure
#13
EDITORIAL
Mikihiro Fujiya
Inflammatory bowel disease (IBD) is a major risk factor for colorectal cancer. Surveillance colonoscopy is presumably important for the early detection of colitis-associated cancer/dysplasia (CC/Ds). However, it is not easy to detect certain lesions in the inflamed mucosa using white-light endoscopy (WLE), even during the remission phase. Therefore, WLE with random biopsies has been the traditional approach for dysplasia detection. Recent advances in endoscopic technologies, including high-definition endoscopy and image-enhanced endoscopy, have improved the visibility of dysplastic lesions, suggesting that novel endoscopic procedures with a target biopsy are suitable for the surveillance of CC/Ds[1]...
January 23, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29342997/-x-linked-inhibitor-of-apoptosis-deficiency-manifested-as-crohn-s-disease-a-case-report-and-literature-review
#14
L J Xu, Y Y Luo, J D Yu, J G Lou, Y H Fang, J Chen
Objective: To analyze the clinical characteristics of X-linked inhibitor of apoptosis (XIAP) deficient patients with clinical manifestation of Crohn's disease. Methods: Clinical manifestations, laboratory investigations, genetic testing and therapeutic interventions of one case of XIAP deficiency who was admitted to Department of Gastroenterology in Children's Hospital, Zhejiang University School of Medicine in May 2016 were summarized. PubMed and Chinese database for articles published from January 2016 to June 2017 were searched using the key words of'Crohn's disease'and'XIAP', and the relevant literature was reviewed...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29334518/is-ileocecal-valve-intubation-essential-for-routine-colonoscopic-examination
#15
Murat Meral, Göksel Bengi, Hasan Kayahan, Mesut Akarsu, Müjde Soytürk, Ömer Topalak, Hale Akpinar, Özgül Sağol
BACKGROUND: In this study, we aimed to assess the diagnostic yield of terminal ileum intubation during routine colonoscopy. MATERIALS AND METHODS: We routinely performed terminal ileum intubation in all patients who underwent colonoscopy at Dokuz Eylul University Hospital between February 2014 and June 2015. Two gastroenterology fellows performed colonoscopies in the Central Endoscopy Unit. Demographic data of patients, indications of colonoscopies, cecum and ileum intubation rate/time, and endoscopic and histopathologic findings of the terminal ileum were all assessed...
January 12, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29321104/neurectomy-for-anterior-cutaneous-nerve-entrapment-syndrome-in-children
#16
Lindsey B Armstrong, Pradeep Dinakar, David P Mooney
INTRODUCTION: Anterior cutaneous nerve entrapment syndrome (ACNES) is an underrecognized etiology of chronic abdominal pain that causes great morbidity to those affected. We sought to determine the outcome of neurectomy for ACNES in children. METHODS: Demographic and clinical data on children who underwent neurectomy for ACNES by a single surgeon from 10/2011 to 01/2017 were reviewed. RESULTS: Twenty-six patients underwent neurectomy for ACNES...
December 8, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29294595/should-asymptomatic-young-men-with-iron-deficiency-anemia-necessarily-undergo-endoscopy
#17
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Background/Aims: There has been no evidence for the necessity of endoscopy in asymptomatic young men with iron deficiency anemia (IDA). To determine whether endoscopy should be recommended in asymptomatic young men with IDA, we compared the prevalence of gastrointestinal (GI) lesions between young men (< 50 years) with IDA and those without IDA. Methods: We conducted a case-control study on asymptomatic young men aged < 50 years who underwent both esophagogastroduodenoscopy (EGD) and colonoscopy as part of a health checkup between 2010 and 2014...
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29278000/capsule-endoscopy-with-pillcamsb2-versus-pillcamsb3-has-the-improvement-in-technology-resulted-in-a-step-forward
#18
Sofia Xavier, Sara Monteiro, Joana Magalhães, Bruno Rosa, Maria João Moreira, José Cotter
AIM: To compare the findings and completion rate of PillCam® SB2 and SB3. METHODS: This was a retrospective single-center study that included 357 consecutive small bowel capsule endoscopies (SBCE), 173 SB2 and 184 SB3. The data collected included age, gender, capsule type (PillCam® SB2 or SB3), quality of bowel preparation, completion of the examination, gastric and small bowel transit time, small bowel findings, findings in segments other than the small bowel and the detection of specific anatomical markers, such as the Z line and papilla...
December 26, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29273328/elevation-of-serum-pyruvate-kinase-m2-pkm2-in-ibd-and-its-relationship-to-ibd-indices
#19
Ahmed A Almousa, Marc Morris, Sharyle Fowler, Jennifer Jones, Jane Alcorn
OBJECTIVES: Endoscopy remains the gold standard to diagnose and evaluate inflammatory bowel disease (IBD) activity. Current biomarkers or their combinations cannot adequately predict IBD risk, diagnosis, progression or relapse, and response to therapy. Pyruvate kinase M2 (PKM2) is emerging as a significant mediator of the inflammatory process. We aimed to assess levels of serum PKM2 in healthy and newly diagnosed IBD patients and its relationship with IBD indices and microbiota changes...
December 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29261528/clinical-presentation-and-outcomes-of-diagnostic-endoscopy-in-newly-presenting-children-with-gastrointestinal-symptoms
#20
Shuang Wang, Osman Younus, David Rawat, Sandhia Naik, Edward Giles, Nigel Meadows, Nicholas M Croft
OBJECTIVES: Paediatric endoscopy is an important diagnostic tool however there is little published data to guide clinicians in selecting patients for endoscopy. This study aimed to evaluate a single centre's experience of newly presenting children focusing on presenting symptoms, investigations and diagnostic yield. METHODS: Clinical factors and endoscopic plus histological findings over a six-month period were assessed. Only first diagnostic endoscopies were included...
December 19, 2017: Journal of Pediatric Gastroenterology and Nutrition
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