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Endoscopy Inflammatory bowel

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https://www.readbyqxmd.com/read/28172839/p276-a-snap-shot-review-of-small-bowel-capsule-endoscopy-in-the-setting-of-inflammatory-bowel-disease
#1
R Stack, L Ridgeway, N Moran, N Breslin, B Ryan, D Mc Namara
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172746/dop065-use-of-chromoendoscopy-versus-white-light-endoscopy-for-colorectal-cancer-surveillance-in%C3%A2-inflammatory-bowel-disease-patients-with-primary-sclerosing-cholangitis-a-six-year-experience
#2
K Hartery, K Williamson, R Chapman, N Atkinson, J East
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28150131/inflammatory-bowel-disease-unclassified-in-children-diagnosis-and-pharmacological-management
#3
Giulia D'Arcangelo, Marina Aloi
Inflammatory bowel diseases are chronic disorders of the gastrointestinal tract that include Crohn's disease (CD), ulcerative colitis (UC) and inflammatory bowel disease-unclassified (IBDU). The latter defines a subgroup of patients with clinical and endoscopic evidence of chronic colitis, without specific features of either CD or UC. These patients will possibly be re-classified as having UC or CD during the follow-up, although a significant percentage of them will keep the diagnosis of IBDU. IBDU is the rarest subtype of IBD, both in children and in adults, although it is twice as common among the pediatric population, especially in the younger ages...
February 1, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28138859/utility-of-biomarkers-in-the-management-of-inflammatory-bowel-disease
#4
REVIEW
Gursimran Kochhar, Bret Lashner
Inflammatory bowel disease (IBD) is comprised of complex clinical and pathological conditions. It runs a chronic course, and proper management requires constant monitoring of disease activity. Recent evidence suggests that subjective patient scores have a poor correlation with disease activity. Endoscopy remains the gold standard for diagnosing and monitoring disease activity. As healthcare is moving towards less costly and less invasive treatments, the need for biomarkers in the management of IBD is evident...
January 30, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28126349/full-spectrum-endoscopy-improves-surveillance-for-dysplasia-in-patients-with-inflammatory-bowel-diseases
#5
Rupert W Leong, Marie Ooi, Crispin Corte, Yunki Yau, Melissa Kermeen, Peter H Katelaris, Charles McDonald, Meng Ngu
BACKGROUND & AIMS: Inflammatory bowel diseases (IBD) increase the risk of colorectal cancer. Surveillance colonoscopy with chromoendoscopy is recommended, but conventional forward-viewing colonoscopy (FVC) detects dysplasia with low levels of sensitivity. Full-spectrum endoscopy (FUSE) incorporates 2 additional lateral cameras to the forward camera of the colonoscope, allowing endoscopists to view behind folds and in blind spots, which might increase dysplasia detection. We compared FUSE vs FVC in the detection of dysplasia in patients with IBD...
January 23, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28125562/o-014-bacterial-sensor-nod2-deletion-causes-th2-inflammatory-bowel-disease-improvement-without-inducing-acute-metatranscriptomic-dysbiosis-in-mice
#6
Alexander Rodriguez-Palacios, Daniele Corridoni, Gabriella Di Stefano, Luca Di Martino, D A Antonopoulos, Eugene Chang, T T Pizarro, Fabio Cominelli
BACKGROUND: Although single nucleotide polymorphisms in the NOD2 (nucleotide-binding oligomerization domain-containing 2) gene have been associated with the pathogenesis of Crohn's disease (CD), little is known about the role of nonpolymorphic wild-type (WT) NOD2 genes in the gut. To date, most animal studies addressing the role of WT NOD2 have been conducted using healthy (ileitis/colitis-free) mouse strains, and have attributed a modulating effect to the gut microbiome, partly based on 16S rRNA sequencing...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28104987/estimation-of-quality-of-life-in-cypriot-patients-with-inflammatory-bowel-disease
#7
Maria Tsoukka, Eleni Jelastopulu, Giagkos Lavranos, George Charalambous
AIM: To investigate the health-related quality of life (HRQoL) of patients suffering with idiopathic inflammatory bowel disease (IBD). METHODS: The Greek validated version of the Short Inflammatory Bowel Disease Questionnaire was used for evaluating the quality of life of IBD patients. The questionnaire was distributed to 100 consecutive patients suffering from IBD and presenting for a clinic appointment at the endoscopy unit of Larnaca General Hospital during the period from October to November 2012...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28103205/is-the-use-of-agile-patency-capsule-prior-to-videocapsule-endoscopy-useful-in-all-patients-with-spondyloarthritis
#8
Andrada Gheorghe, Denise Carmen Mihaela Zahiu, Theodor Alexandru Voiosu, Bogdan Radu Mateescu, Mihail Radu Voiosu, Mihai Rimbaş
BACKGROUND AND AIMS: As already known, spondyloarthritis patients present a striking resemblance in intestinal inflammation with early Crohn's disease. Moreover, the frequent use of nonsteroidal anti-inflammatory drugs is an important part of their treatment. Both conditions could lead to intestinal stenoses. Therefore we proposed to investigate the usefulness of the patency capsule test in patients with spondyloarthritis. MATERIAL AND METHODS: 64 consecutive patients (33 males; mean age 38 ± 11 years) that fulfilled the AMOR criteria for seronegative spondyloarthropathy (59...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28103201/different-effects-of-anti-tnf-alpha-biologic-drugs-on-the-small-bowel-macroscopic-inflammation-in-patients-with-ankylosing-spondylitis
#9
A Chitul, A M Voiosu, Mădălina Marinescu, Simona Caraiola, Adriana Nicolau, Georgeta Camelia Badea, Magda Ileana Pârvu, R A Ionescu, B R Mateescu, M R Voiosu, C R Băicuș, M Rimbaș
: Background&Aims: Considering the ability of anti-TNF alpha drugs to lower the burden intestinal inflammation in patients with inflammatory bowel disease (IBD), and the similarity between IBD and ankylosing spondylitis (AS) regarding inflammatory intestinal involvement, we aimed to investigate the impact of anti-TNF alpha biologic therapy on subclinical intestinal inflammation in AS patients. METHODS: Between January 2008 and December 2013, 38 AS patients and 23 controls were enrolled in the study and investigated with small bowel videocapsule endoscopy examination and ileocolonoscopy...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28101306/essential-role-of-small-bowel-capsule-endoscopy-in-reclassification-of-colonic-inflammatory-bowel-disease-type-unclassified
#10
Sara Monteiro, Francisca Dias de Castro, Pedro Boal Carvalho, Bruno Rosa, Maria João Moreira, Rolando Pinho, Miguel Mascarenhas Saraiva, José Cotter
AIM: To evaluate the role of small bowel capsule endoscopy (SBCE) on the reclassification of colonic inflammatory bowel disease type unclassified (IBDU). METHODS: We performed a multicenter, retrospective study including patients with IBDU undergoing SBCE, between 2002 and 2014. SBCE studies were reviewed and the inflammatory activity was evaluated by determining the Lewis score (LS). Inflammatory activity was considered significant and consistent with Crohn's disease (CD) when the LS ≥ 135...
January 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28069475/retention-associated-with-video-capsule-endoscopy-systematic-review-and-meta-analysis
#11
REVIEW
Mona Rezapour, Chidi Amadi, Lauren Gerson
BACKGROUND: Video capsule endoscopy (VCE) has become a major diagnostic tool for small-bowel evaluation. However, retention of the video capsule endoscope remains a major concern. METHODS: We performed a systematic review of VCE retention rates using Pubmed and SCOPUS (1995-2015). We included studies that enrolled at least 10 subjects, included VCE retention rates, and separated retention rates by indication. We used Comprehensive Meta-Analysis (Version 3.0) to calculate pooled prevalence rates with 95% confidence intervals and assessed heterogeneity using Cochran's Q statistic...
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28066855/spectrum-of-small-bowel-mucosal-abnormalities-identified-by-capsule-endoscopy-in-patients-with-portal-hypertension-of-varied-etiology
#12
T S Chandrasekar, Gokul Bollu Janakan, Viveksandeep Thoguluva Chandrasekar, Raja Yogesh Kalamegam, Sathiamoorthy Suriyanarayanan, Prasad Menta Sanjeevaraya
BACKGROUND: Bleeding from small intestinal ectopic varices and persistent anemia caused by portal hypertensive enteropathy (PHE) can be very challenging. Capsule endoscopy (CE) is one of the best noninvasive modalities in identifying such lesions. AIM: The aims of this study are to study the prevalence of small-bowel changes related to portal hypertension (PHT) and to correlate them with the observations related to the effects of portal hypertension in the esophagus, stomach, and colon...
January 9, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28045777/capillary-flow-rates-in-the-duodenum-of-pediatric-ulcerative-colitis-patients-are-increased-and-unrelated-to-inflammation
#13
Deenaz Zaidi, Lucas Churchill, Hien Q Huynh, Matthew W Carroll, Rabin Persad, Eytan Wine
BACKGROUND: Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are chronic pediatric disorders. Changes in vasculature are described in IBD but these could be secondary to inflammation and the role in pathogenesis is poorly understood. Assessing circulatory changes in typically unaffected sites in IBD (e.g., duodenum), when inflammation is absent, can identify vascular changes associated with pathogenesis. AIM: To measure capillary flow rates in duodenal mucosa using probe-based confocal laser endomicroscopy (pCLE) during endoscopy in children with IBD...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28042391/identification-of-factors-associated-with-sedation-tolerance-in-5000-patients-undergoing-outpatient-colonoscopy-canadian-tertiary-center-experience
#14
Alexandra Shingina, George Ou, Oliver Takach, Sigrid Svarta, Ricky Kwok, Jessica Tong, Kieran Donaldson, Eric Lam, Robert Enns
AIM: To develop a prediction model aimed at identifying patients that may require higher than usual sedation doses during colonoscopy. METHODS: A retrospective chart review on 5000 patients who underwent an outpatient colonoscopy at St. Paul's Hospital from 2009 to 2010 was conducted in order to develop a model for identifying patients who will require increased doses of sedatives. Potential predictor variables including age, gender, endoscopy indication, high sedation requirements during previous endoscopies, difficulty of the procedure, bowel preparation quality, interventions, findings as well as current use of benzodiazepines, opioids and alcohol were analyzed...
December 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28042386/endoscopic-evaluation-in-diagnosis-and-management-of-inflammatory-bowel-disease
#15
REVIEW
Carthage P Moran, Barra Neary, Glen A Doherty
Endoscopy is a keystone in the management of patients with inflammatory bowel disease (IBD). It is the fundamental diagnostic tool for IBD, and can help discern between ulcerative colitis and Crohn's disease. Endoscopic assessment provides an objective end point in clinical trials, and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy. Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy, and chromoendoscopy...
December 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28028368/nodular-lymphoid-hyperplasia-a-marker-of-low-grade-inflammation-in-irritable-bowel-syndrome
#16
Anna Chiara Piscaglia, Lucrezia Laterza, Valentina Cesario, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Giovanni Calò, Giovanna Fabbretti, Massimo Brisigotti, Maria Loredana Stefanelli, Antonio Gasbarrini
AIM: To evaluate the prevalence of nodular lymphoid hyperplasia (NLH) in adult patients undergoing colonoscopy and its association with known diseases. METHODS: We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome (IBS)-type symptoms or suspected inflammatory bowel disease (IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening. Data collection included medical history and final diagnosis...
December 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28007576/rifaximin-reduces-number-and-severity-of-intestinal-lesions-associated-with-use-of-non-steroidal-anti-inflammatory-drugs-in-humans
#17
Carmelo Scarpignato, Werner Dolak, Angel Lanas, Peter Matzneller, Cecilia Renzulli, Maria Grimaldi, Markus Zeitlinger, Ingvar Bjarnason
The intestinal microbiota might contribute to enteropathy associated with use of non-steroidal anti-inflammatory drugs (NSAIDs), but there have been few human studies of this association. We performed a placebo-controlled study to determine whether a delayed release antibiotic formulation (rifaximin-EIR) prevented development of intestinal lesions in persons taking daily NSAIDs. Sixty healthy volunteers (median age 26 years, 42% female) were given the NSAID diclofenac (75 mg twice daily) plus omeprazole (20 mg once daily), and either rifaximin-EIR (400 mg) or placebo, twice daily for 14 days...
December 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/28000302/pd-1-inhibitor-gastroenterocolitis-case-series-and-appraisal-of-immunomodulatory-gastroenterocolitis
#18
Raul S Gonzalez, Safia N Salaria, Caitlin D Bohannon, Aaron R Huber, Michael M Feely, Chanjuan Shi
AIMS: PD-1 inhibitors facilitate immune response against certain tumour types, including melanoma. These drugs have led to prolonged survival but can also result in autoimmune-type side effects, including gastrointestinal inflammation. The histopathological effects of this medication class have not been well studied. METHODS AND RESULTS: We identified 37 gastrointestinal tract biopsies from 20 patients taking a PD-1 or PD-L1 inhibitor and evaluated clinicopathological findings...
March 2017: Histopathology
https://www.readbyqxmd.com/read/27989951/published-diagnostic-models-safely-excluded-colorectal-cancer-in-an-independent-primary-care-validation-study
#19
Sjoerd G Elias, Liselotte Kok, Ben J M Witteman, Jelle G Goedhard, Mariëlle J L Romberg-Camps, Jean W M Muris, Niek J de Wit, Karel G M Moons
OBJECTIVE: To validate published diagnostic models for their ability to safely reduce unnecessary endoscopy referrals in primary care patients suspected of significant colorectal disease. STUDY DESIGN AND SETTING: Following a systematic literature search, we independently validated the identified diagnostic models in a cross-sectional study of 810 Dutch primary care patients with persistent lower abdominal complaints referred for endoscopy. We estimated diagnostic accuracy measures for colorectal cancer (N=37) and significant colorectal disease (N=141; including colorectal cancer, inflammatory bowel disease, diverticulitis, or >1cm adenomas)...
October 28, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27957517/crohn-s-disease-activity-abdominal-computed-tomography-histopathology-correlation
#20
N Paquet, J N Glickman, S M Erturk, P R Ros, J T Heverhagen, M A Patak
PURPOSE: Crohn's disease is a type of inflammatory bowel disease affecting estimated 4 million people worldwide. Therapy stratification of Crohn's disease (CD) is mainly based on the inflammatory activity being assessed by endoscopic biopsy and clinical criteria. Cross-sectional imaging allows for the assessment of structural characteristics of the entire gastrointestinal tract including small bowel loops and may provide potential non-invasive image-based biomarkers for the inflammatory activity of CD...
2016: European Journal of Radiology Open
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