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Endoscopy Inflammatory bowel

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https://www.readbyqxmd.com/read/29211800/diagnostic-test-strategies-in-children-at-increased-risk-of-inflammatory-bowel-disease-in-primary-care
#1
Gea A Holtman, Yvonne Lisman-van Leeuwen, Boudewijn J Kollen, Obbe F Norbruis, Johanna C Escher, Laurence C Walhout, Angelika Kindermann, Yolanda B de Rijke, Patrick F van Rheenen, Marjolein Y Berger
BACKGROUND: In children with symptoms suggestive of inflammatory bowel disease (IBD) who present in primary care, the optimal test strategy for identifying those who require specialist care is unclear. We evaluated the following three test strategies to determine which was optimal for referring children with suspected IBD to specialist care: 1) alarm symptoms alone, 2) alarm symptoms plus c-reactive protein, and 3) alarm symptoms plus fecal calprotectin. METHODS: A prospective cohort study was conducted, including children with chronic gastrointestinal symptoms referred to pediatric gastroenterology...
2017: PloS One
https://www.readbyqxmd.com/read/29152990/gastroduodenal-lesions-detected-during-small-bowel-capsule-endoscopy-incidence-diagnostic-and-therapeutic-impact
#2
José Francisco Juanmartiñena Fernández, Ignacio Fernández-Urien Sainz, Beatriz Zabalza Ollo, Cristina Saldaña Dueñas, Marta Montañés Guimera, Alfonso Elosua González, Juan José Vila Costas
BACKGROUND: Capsule endoscopy was primarily designed for the investigation of the small bowel. However, it may also identify lesions in other segments of the gastrointestinal tract. The aim of the current study was to evaluate the incidence of gastroduodenal abnormalities during small bowel capsule endoscopy and its impact on patient diagnosis and management. PATIENTS AND METHODS: This study is a retrospective analysis of data from 2,217 consecutive capsule endoscopy procedures performed at a single tertiary-care center between January 2008 and February 2016...
November 20, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29151692/fecal-calprotectin-measurement-is-a-marker-of-short-term-clinical-outcome-and-presence-of-mucosal-healing-in-patients-with-inflammatory-bowel-disease
#3
Athanasios Kostas, Spyros I Siakavellas, Charalambos Kosmidis, Anna Takou, Joanna Nikou, Georgios Maropoulos, John Vlachogiannakos, George V Papatheodoridis, Ioannis Papaconstantinou, Giorgos Bamias
AIM: To evaluate the utility of fecal calprotectin (FC) in predicting relapse and endoscopic activity during follow-up in an inflammatory bowel disease (IBD) cohort. METHODS: All FC measurements that were obtained during a 3-year period from patients with inflammatory bowel disease in clinical remission were identified. Data regarding the short-term (6 mo) course of the disease were extracted from the medical files. Exclusion criteria were defined as: (1) An established flare of the disease at the time of FC measurement, (2) Loss to follow up within 6 mo from baseline FC measurement, and, (3) Insufficient data on file...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29142512/non-steroidal-anti-inflammatory-drug-induced-enteropathy
#4
REVIEW
Sung Jae Shin, Choong-Kyun Noh, Sun Gyo Lim, Kee Myung Lee, Kwang Jae Lee
Non-steroidal anti-inflammatory drugs (NSAIDs) are well known to be associated with serious upper gastrointestinal complications, such as peptic ulcer, bleeding, perforation, and obstruction. Recently, attention has been mainly focused on the small bowel injuries caused by NSAIDs, and new endoscopic techniques such as capsule endoscopy and double balloon endoscopy can help in detecting such injuries. This article reviewed the epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of small bowel injuries caused by NSAIDs...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29118554/risk-factors-for-postoperative-recurrence-of-crohn-s-disease-with-emphasis-on-surgical-predictors
#5
REVIEW
Antonios Gklavas, Dionysios Dellaportas, Ioannis Papaconstantinou
Intestinal resection for Crohn's disease is not curative and postoperative recurrence rates remain high. Early detection of indices associated with recurrence and risk stratification are fundamental for the postoperative management of patients. Early endoscopy at 6-12 months is the "gold standard" procedure, whereas other modalities such as fecal calprotectin and imaging techniques can contribute to the diagnosis of recurrence. The purpose of this review is to summarize current data regarding risk factors correlated with postoperative relapse...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29112087/fecal-amino-acid-analysis-can-discriminate-de-novo-treatment-na%C3%A3-ve-pediatric-inflammatory-bowel-disease-from-controls
#6
Sofie Bosch, Eduard A Struys, Nora van Gaal, Abdellatif Bakkali, Erwin W Jansen, Kay Diederen, Marc A Benninga, Chris J Mulder, Nanne K H de Boer, Tim G J de Meij
OBJECTIVES: Endoscopy remains mandatory in the diagnostic work-up of inflammatory bowel disease (IBD), but is a costly and invasive procedure. Identification of novel, non-invasive, diagnostic biomarkers remains a priority. The aim of this study was to explore the potential of fecal amino acid composition as diagnostic biomarker for pediatric IBD. METHODS: In this case-control study, treatment-naïve, de novo pediatric IBD patients from two tertiary centers were included...
November 3, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29110316/asymptotic-distributions-of-kappa-statistics-and-their-differences-with-many-raters-many-rating-categories-and-two-conditions
#7
Luca Grassano, Guido Pagana, Marco Daperno, Enrico Bibbona, Mauro Gasparini
In clinical research and in more general classification problems, a frequent concern is the reliability of a rating system. In the absence of a gold standard, agreement may be considered as an indication of reliability. When dealing with categorical data, the well-known kappa statistic is often used to measure agreement. The aim of this paper is to obtain a theoretical result about the asymptotic distribution of the kappa statistic with multiple items, multiple raters, multiple conditions, and multiple rating categories (more than two), based on recent work...
November 7, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29107471/quality-of-care-indicators-in-inflammatory-bowel-disease-in-a-tertiary-referral-center-with-open-access-and-objective-assessment-policies
#8
Lorant Gonczi, Zsuzsanna Kurti, Petra Anna Golovics, Barbara Dorottya Lovasz, Orsolya Menyhart, Anna Seres, Liza Dalma Sumegi, Alexander Gal, Akos Ilias, Papp Janos, Krisztina Barbara Gecse, Talat Bessisow, Waqqas Afif, Alain Bitton, Zsuzsanna Vegh, Peter Laszlo Lakatos
BACKGROUND: In the management of inflammatory bowel diseases, there is considerable variation in quality of care. AIMS: The aim of this study was to evaluate structural, access/process components and outcome quality indicators in our tertiary referral IBD center. METHODS: In the first phase, structural/process components were assessed, followed by the second phase of formal evaluation of access and management on a set of consecutive IBD patients with and without active disease (248CD/125UC patients, median age 35/39 years)...
October 9, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29097649/characteristics-of-nonsteroidal-anti-inflammatory-drugs-nsaids-induced-small-bowel-injury-identified-by-single-balloon-endoscopy-or-capsule-endoscopy
#9
Ning Xu, Zhenhai Yu, Xiaoling Cao, Zhihua Wang, Ming Yan
BACKGROUND The special features of nonsteroidal anti-inflammatory drugs (NSAIDs) enteropathy were partially clarified by single-balloon endoscopy(SBE). We aimed to investigate the characteristics of NSAIDs injuries that were differ from other ulcer diseases and efficacy of SBE compared with capsule endoscopy(CE). MATERIAL AND METHODS 1,644 symptomatic patients (221 patients taking NSAIDs) hospitalized between January 2006 and March 2016 were recruited and underwent SBE and/or CE. RESULTS NSAIDs damages were identified in 110 patients (49...
November 3, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29075256/imaging-of-mucosal-inflammation-current-technological-developments-clinical-implications-and-future-perspectives
#10
REVIEW
Maximilian J Waldner, Timo Rath, Sebastian Schürmann, Christian Bojarski, Raja Atreya
In recent years, various technological developments markedly improved imaging of mucosal inflammation in patients with inflammatory bowel diseases. Although technological developments such as high-definition-, chromo-, and autofluorescence-endoscopy led to a more precise and detailed assessment of mucosal inflammation during wide-field endoscopy, probe-based and stationary confocal laser microscopy enabled in vivo real-time microscopic imaging of mucosal surfaces within the gastrointestinal tract. Through the use of fluorochromes with specificity against a defined molecular target combined with endoscopic techniques that allow ultrastructural resolution, molecular imaging enables in vivo visualization of single molecules or receptors during endoscopy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29074448/patient-reported-outcome-measures-for-use-in-clinical-trials-and-clinical-practice-in-inflammatory-bowel-diseases-a-systematic-review
#11
REVIEW
M J de Jong, R Huibregtse, A A M Masclee, D M A E Jonkers, M J Pierik
BACKGROUND & AIMS: Mucosal inflammation must be carefully monitored to improve the long-term outcomes of patients with inflammatory bowel diseases (IBD). Patient-reported outcome measures (PROMs) are used increasingly to monitor disease activity in clinical practice and as endpoints in clinical trials. We performed a systematic review to provide an overview of the available PROMs on IBD activity and to evaluate their diagnostic value. METHODS: A systematic search of the PubMed, Medline, Cochrane library, and Embase databases using defined keywords, identified 973 articles...
October 23, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29067041/paediatric-inflammatory-bowel-disease-clinical-presentation-and-disease-location
#12
Danish Abdul Aziz, Maryum Moin, Atif Majeed, Kamran Sadiq, Abdul Gaffar Biloo
OBJECTIVE: To determine different clinical presentationsand disease location demarcatedby upper and lower gastrointestinal endoscopyand relevant histopathologyin children diagnosed with inflammatory bowel disease (IBD). METHODS: This is 5 years (2010 to 2015) retrospective studyconducted at the Aga Khan University Hospitalenrolling65admitted children between 6 months to 15years from either gender, diagnosed with IBD on clinical presentation, endoscopy and biopsy...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29043862/the-potential-role-of-fdg-pet-ct-in-the-characterization-of-the-activity-of-crohn-s-disease-staging-follow-up-and-prognosis-estimation-a-pilot-study
#13
Károly Palatka, Sándor Kacska, Szilvia Lovas, Ildikó Garai, József Varga, László Galuska
OBJECTIVES: FDG PET-CT is a global, noninvasive, sensitive method to determine the location and activity of inflammatory lesions. Segmental FDG uptake is proportional with immune cell infiltration of bowel. Our aim was to evaluate prospectively the role of PET in patients with active Crohn's disease (CD) before and after one year's biological therapy, and to compare simple endoscopic score for CD (SES-CD), CD activity index (CDAI) and global PET scores. We also analyzed the prognostic value of initial PET scores...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29019424/endoscopy-for-patients-affected-by-inflammatory-bowel-disease-bowel-preparation-and-sedation
#14
Cristina Bezzio, Paolo Andreozzi, Valentina Casini, Gianpiero Manes, Simone Saibeni
Endoscopy has a key role in the management of inflammatory bowel disease (IBD). It is helpful in the diagnosis, in case of relapse, refractoriness, before therapeutic changes, after surgery as well as in the assessment of mucosal healing and in the surveillance of colo-rectal cancer. IBD patients are intended to undergo several times the examination during their lifespan. Bowel preparation and sedation highly contribute to high-quality colonoscopy. Areas covered: Few studies addressed preparation and sedation in the field of IBD...
October 17, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29017297/endoscopic-balloon-dilation-for-crohn-s-disease-associated-strictures
#15
REVIEW
Thomas Klag, Jan Wehkamp, Martin Goetz
Management of intestinal strictures associated with Crohn's disease (CD) is clinically challenging despite advanced medical therapy directed toward mucosal healing to positively influence the natural course of CD-associated complications. Although medical therapy is available for inflammatory strictures, therapy of fibrostenotic strictures is the domain of surgery and endoscopy. Endoscopic balloon dilation (EBD) has been recognized as a well-established first-line procedure in terms of safety and efficacy. Although surgery is a valuable treatment modality for the management of CD-related strictures, EBD can help prevent multiple surgical interventions, which might in the long-term lead to a risk of short bowel syndrome...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29017295/balloon-assisted-enteroscopy-and-capsule-endoscopy-in-suspected-small-bowel-crohn-s-disease
#16
REVIEW
Hsu-Heng Yen, Chen-Wang Chang, Jen-Wei Chou, Shu-Chen Wei
Inflammatory bowel diseases are idiopathic inflammatory diseases of two main types, Crohn's disease and ulcerative colitis. Crohn's disease can affect the entire gastrointestinal tract, and the distal ileum is involved in up to 70% of patients. Moreover, Crohn's disease in one-quarter to one-third of patients involves isolation of the small bowel. Due to the nonspecific symptoms and anatomical location of the disease, small bowel Crohn's disease is a phenotype that is particularly difficult to manage. Since the introduction of capsule endoscopy in 2000 and balloon-assisted enteroscopy in the 21st century, it is now possible to directly inspect for small bowel Crohn's disease...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29017290/role-of-advanced-endoscopic-imaging-techniques-in-the-management-of-inflammatory-bowel-disease
#17
REVIEW
Eun Soo Kim
Endoscopy plays a crucial role in the management of inflammatory bowel disease (IBD) in terms of diagnosis, monitoring of mucosal status, and surveillance of colitis-associated neoplasia. Mucosal healing evaluated by endoscopy has been recognized as the target of treatment in the era of powerful biologics therapy. The optimal modality for identifying dysplasia in IBD has yet to be well defined. Increasing progress has recently been made in endoscopic technologies to more accurately assess mucosal inflammation and more effectively detect dysplasia...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28987547/endoscopy-in-inflammatory-bowel-disease-advances-in-dysplasia-detection-and-management
#18
REVIEW
Tonya Kaltenbach, William J Sandborn
No abstract text is available yet for this article.
December 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28984252/long-term-outcome-of-inflammatory-bowel-disease-unclassified-in-children
#19
Siba Prosad Paul, Bhupinder Kaur Sandhu
OBJECTIVE: To document the frequency at diagnosis and evolution over time of inflammatory bowel disease-unclassified in children. METHODS: Analysis of case records (2004-2011) of patients diagnosed with inflammatory bowel disease-unclassified following upper-gastrointestinal endoscopy, ileocolonoscopy and small bowel imaging. Any subsequent diagnostic reclassification by 2016 was recorded. RESULTS: 344 children diagnosed as inflammatory bowel disease: 58% Crohn's disease, 34...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28983504/perspectives-on-endoscopic-surveillance-of-dysplasia-in-inflammatory-bowel-disease-a-survey-of-academic-gastroenterologists
#20
Zane R Gallinger, Amir Rumman, Sanjay K Murthy, Geoffrey C Nguyen
BACKGROUND AND STUDY AIMS:  Dye-based chromoendoscopy (DBC) is the preferred method for endoscopic dysplasia surveillance in patients with inflammatory bowel disease (IBD). We sought to examine the uptake of, and perception toward DBC among academic gastroenterologists. METHODS:  We conducted an online survey of academic members of the Canadian Association of Gastroenterology to assess their current dysplasia surveillance practice, uptake of DBC, and perceived barriers to adoption of DBC...
October 2017: Endoscopy International Open
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