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https://www.readbyqxmd.com/read/28516248/environmental-toxicants-incidence-of-degenerative-diseases-and-therapies-from-the-epigenetic-point-of-view
#1
REVIEW
Mahshid Hodjat, Soheila Rahmani, Fazlullah Khan, Kamal Niaz, Mona Navaei-Nigjeh, Solmaz Mohammadi Nejad, Mohammad Abdollahi
Epigenotoxicology is an emerging field of study that investigates the non-genotoxic epigenetic effects of environmental toxicants resulting in alteration of normal gene expression and disruption of cell function. Recent findings on the role of toxicant-induced epigenetic modifications in the development of degenerative diseases have opened up a promising research direction to explore epigenetic therapy approaches and related prognostic biomarkers. In this review, we presented comprehensive data on epigenetic alterations identified in various diseases, including cancer, autoimmune disorders, pulmonary conditions as well as cardiovascular, gastrointestinal and bone disease...
May 17, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28501516/is-dual-inhibition-of-metalloenzymes-hdac-8-and-mmp-2-a-potential-pharmacological-target-to-combat-hematological-malignancies
#2
REVIEW
Sk Abdul Amin, Nilanjan Adhikari, Tarun Jha
For the last three decades, metalloenzymes such as histone deacetylases (HDACs) and matrix metalloproteinases (MMPs) have been identified in promoting solid as well as hematological carcinogenesis. Histone deacetylase 8 (HDAC-8), a class I HDAC enzyme, may serve as 'epigenetic player' that affects in the regulation of transcription factors and alters the structure of chromosome associated with tumorigenesis. It is established that the influence of MMP-2 in invasion, metastasis and angiogenenic events of hematological malignancies may be suppressed by HDAC inhibitors through reversion-inducing-cysteine-rich protein with kazal motifs (RECK) protein...
May 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28492018/impact-of-leishmaniasis-in-women-a-practical-review-with-an-update-on-my-isd-supported-initiative-to-combat-leishmaniasis-in-yemen-elyp
#3
REVIEW
Mohamed A Al-Kamel
Stigma is synonymous with leishmaniasis, an endemic deadly flesh-eating disease in Yemen that affects predominantly poor rural women and children. Women with leishmaniasis often present late and experience not only physical deformities and the risk of death, but also the painful stigma of the disease and its consequences, a similar situation to that of leprosy decades ago. The International Society of Dermatology-sponsored community dermatology project Eradication of Leishmaniasis from Yemen Project has made a difference in the leishmaniasis situation in Yemen and addressed its magnitude...
September 2016: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28490333/micronutrient-powders-to-combat-anemia-in-young-children-does-it-work
#4
Frank T Wieringa
In developing countries, anemia and iron deficiency in early childhood are two highly prevalent public health problems. Providing caregivers with a powder containing multiple vitamins and minerals (also known as micronutrient powder or MNP) as a food supplement is a widely used strategy to combat these problems. However, concerns exist around MNP programs with regards to effectiveness and potential negative impact on diarrheal disease prevalence and gut flora. Teshome et al. (BMC Medicine 15:89, 2017) recently tested a MNP with a new iron formulation, iron-EDTA, which has a potentially higher bioavailability and thus requires a lower iron content...
May 11, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28489578/inhibiting-translesion-dna-synthesis-as-an-approach-to-combat-drug-resistance-to-dna-damaging-agents
#5
Jung-Suk Choi, Seol Kim, Edward Motea, Anthony Berdis
Anti-cancer agents exert therapeutic effects by damaging DNA. Unfortunately, DNA polymerases can effectively replicate the formed DNA lesions to cause drug resistance and create more aggressive cancers. To understand this process at the cellular level, we developed an artificial nucleoside that visualizes the replication of damaged DNA to identify cells that acquire drug resistance through this mechanism. Visualization is achieved using "click" chemistry to covalently attach azide-containing fluorophores to the ethynyl group present on the nucleoside analog after its incorporation opposite damaged DNA...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28486327/tourniquets-in-trauma-care-a-review-of-application
#6
Brian Cornelius, Ryan Campbell, Pat McGauly
Traumatic hemorrhage has been identified as the leading cause of battlefield death in recent conflicts. Although injury patterns are not directly reproducible to the civilian world, treatment advancements can be used to provide care to patients worldwide. Long-standing dogma regarding the use of tourniquets has been disproved, and there is now recognition of the critical role that tourniquets play in trauma care. The history and evolution of tourniquets, including the identification of previous faults in application, will lead to an examination of the current devices in use along with evidence-based recommendations for use...
May 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28484059/funding-instability-reduces-the-impact-of-the-federal-teaching-health-center-graduate-medical-education-program
#7
Troy Kurz, Winston Liaw, Peter Wingrove, Stephen Petterson, Andrew Bazemore
The Teaching Health Center Graduate Medical Education (THCGME) program is a decentralized residency training component of the Affordable Care Act, created to combat critical shortages and maldistribution of primary care physicians. The Accreditation Council of Graduate Medical Education and federal data reveal that the THCGME program accounted for 33% of the net increase in family medicine residency positions between 2011 and 2015. However, amid concerns about the program's stability, the contribution of the THCGME program to the net increase fell to 7% after 2015...
May 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28480874/emerging-applications-of-nanotechnology-for-diagnosis-and-therapy-of-disease-a-review
#8
Richard H Bayford, Tom Rademacher, Ivan Roitt, Scarlet Wang
Nanotechnology is of increasing interest in the fields of medicine and physiology over recent years. Its application could considerably improve disease detection and therapy, and although the potential is considerable, there are still many challenges, which need to be addressed before it is accepted in routine clinical use. This review focuses on emerging applications that nanotechnology could enhance or provide new approaches in diagnoses and therapy. The main focus of recent research centres on targeted therapies and enhancing imaging; however, the introduction of nanomaterial into the human body must be controlled, as there are many issues with possible toxicity and long-term effects...
May 8, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28476719/review-medicinal-plants-and-management-of-diabetes-mellitus-a-review
#9
Sodah Bint Mustafa, Zahid Mehmood, Naheed Akhter, Abida Kauser, Iqbal Hussain, Abid Rashid, Muhammad Akram, Imtiaz Mahmood Tahir, Naveed Munir, Muhammad Riaz, Samia Gul Niazi, Abid Ali, Muhammad Mudassar Ashraf, Umbreen Naz, Hammad Ahmed, S M Ali Shah, Khan Usmanghani
Diabetes is a metabolic disorder characterized by chronic hyperglycemia and associated with dysfunction and failure of various body organs. Alarming increase in prevalence rate has made this disorder a major health problem globally. The available treatment modalities are not sufficient to combat diabetes and associated complications. A number of medicinal plants have a significant antidiabetic potential against diabetes mellitus. We have listed the use of important medicinal herbs for the treatment and management of diabetes in this review...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28474553/metal-complex-peptide-conjugates-how-to-modulate-bioactivity-of-metal-containing-compounds-by-the-attachment-to-peptides
#10
Ines Neundorf
During the last years the interest in combining the features of metal-containing molecules with biomolecules, particularly peptides, has more and more increased. Large series of new innovative organometallic compounds, as well as potent coordination complexes have been designed and, especially in medicinal chemistry, the library of bioactive compounds was excessively expanded by the introduction of metal complexes. The research foci are divers and not limited to e.g. the development of therapeutics with anti-proliferative or antibacterial activity, or the design of novel biosensors useful for pharmaceutical applications...
May 4, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28472843/targeting-multiple-myeloma-cancer-stem-cells-with-natural-products-lessons-from-other-hematological-malignancies
#11
Mark E Issa, Sylvian Cretton, Muriel Cuendet
Multiple myeloma is characterized by the accumulation of malignant plasma cells in the bone marrow. Multiple myeloma is the second most frequently diagnosed hematological malignancy, predominantly affecting the elderly. Despite recent advances in the development of novel therapies, multiple myeloma remains an incurable malignancy where the majority of patients relapse, develop resistance, and eventually die from the disease. This has been attributed to the fact that conventional therapy currently in use targets mainly the bulk of tumor cells, but not the tumor-initiating cancer stem cells...
May 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/28471351/repurposing-niclosamide-as-a-versatile-antimicrobial-surface-coating-against-device-associated-hospital-acquired-bacterial-infections
#12
Tinotenda Gwisai, Nisha Hollingsworth, Sarah Cowles, Nagendran Tharmalingam, Eleftherios Mylonakis, Beth Fuchs, Anita Shukla
Device-associated and hospital-acquired infections remain amongst the greatest challenges in regenerative medicine. Furthermore, the rapid emergence of antibiotic resistance and lack of new classes of antibiotics has made the treatment of these bacterial infections increasingly difficult. The repurposing of Food and Drug Administration (FDA) approved drugs for antimicrobial therapies is a powerful means of reducing the time and cost associated with drug discovery and development. In this work, niclosamide, a commercially available anthelmintic drug with recently identified antimicrobial properties, was found to prevent and combat existing biofilms of several relevant gram-positive bacteria, namely strains of Staphylococcus aureus, including methicillin resistant S...
May 4, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28466741/-we-need-to-combat-negativity-nursing-is-a-wonderful-career
#13
Stephanie Jones-Berry
Nurse education is undergoing major change in 2017, with new nursing associate and nursing degree apprenticeship routes to registration, as well as proposed changes to education standards. On top of this, undergraduate nursing degrees in England will, as of September, rely on a model of tuition fees and student loans, bringing nursing in line with related subjects such as medicine.
May 3, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28453568/baicalin-inhibits-biofilm-formation-attenuates-the-quorum-sensing-controlled-virulence-and-enhances-pseudomonas-aeruginosa-clearance-in-a-mouse-peritoneal-implant-infection-model
#14
Jing Luo, Biying Dong, Ke Wang, Shuangqi Cai, Tangjuan Liu, Xiaojing Cheng, Danqing Lei, Yanling Chen, Yanan Li, Jinliang Kong, Yiqiang Chen
The quorum sensing (QS) circuit plays a role in the precise regulation of genes controlling virulence factors and biofilm formation in Pseudomonas aeruginosa. QS-controlled biofilm formation by Pseudomonas aeruginosa in clinical settings has remained controversial due to emerging drug resistance; therefore, screening diverse compounds for anti-biofilm or anti-QS activities is important. This study demonstrates the ability of sub-minimum inhibitory concentrations (sub-MICs) of baicalin, an active natural compound extracted from the traditional Chinese medicinal Scutellaria baicalensis, to inhibit the formation of Pseudomonas aeruginosa biofilms and enhance the bactericidal effects of various conventional antibiotics in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28453272/bacterial-iron-uptake-pathways-gates-for-the-import-of-bactericide-compounds
#15
Isabelle J Schalk, Gaƫtan L A Mislin
Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidrug resistant bacteria, especially Gram-negative bacteria for which the situation is particularly critical. Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a promising strategy able to considerably increase the efficacy of drugs. Such a Trojan horse strategy can also extend activity of specific Gram-positive antibiotics to Gram-negative bacteria...
April 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28427561/molecular-targets-of-ascochlorin-and-its-derivatives-for-cancer-therapy
#16
Jason Chua Min-Wen, Benjamin Chua Yan-Jiang, Srishti Mishra, Xiaoyun Dai, Junji Magae, Ng Shyh-Chang, Alan Prem Kumar, Gautam Sethi
Cancer is an extremely complex disease comprising of a multitude of characteristic hallmarks that continue to evolve with time. At the genomic level, random mutations leading to deregulation of diverse oncogenic signal transduction cascades and polymorphisms coupled with environmental as well as life style-related factors are major causative agent contributing to chemoresistance and the failure of conventional therapies as well as molecular targeted agents. Hence, there is an urgent need to identify novel alternative therapies based on alternative medicines to combat this dreaded disease...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28421376/using-the-stopbang-questionnaire-and-other-pre-test-probability-tools-to-predict-osa-in-younger-thinner-patients-referred-to-a-sleep-medicine-clinic
#17
Michael J McMahon, Karen L Sheikh, Teotimo F Andrada, Aaron B Holley
BACKGROUND: The STOPBANG questionnaire is used to predict the presence of obstructive sleep apnea (OSA). We sought to assess the performance of the STOPBANG questionnaire in younger, thinner patients referred to a sleep medicine clinic. METHODS: We applied the STOPBANG questionnaire to patients referred for level I polysomnography (PSG) at our sleep center. We calculated likelihood ratios and area under the receiver operator characteristic (AUROC) curve and performed sensitivity analyses...
April 19, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28411934/tactical-combat-casualty-care-and-wilderness-medicine-advancing-trauma-care-in-austere-environments
#18
REVIEW
Frank K Butler, Brad Bennett, Colonel Ian Wedmore
Tactical Combat Casualty Care (TCCC) is a set of evidence-based, best-practice prehospital trauma care guidelines customized for use on the battlefield. Military units that have trained all of their unit members in TCCC have now documented the lowest incidence of preventable deaths in the history of modern warfare and TCCC is now the standard for battlefield trauma care in the US Military. TCCC and wilderness medicine share the goal of optimizing care for patients with trauma in austere environments that impose significant challenges in both equipment and evacuation capability...
May 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28411893/genomic-approaches-to-hypertension
#19
REVIEW
Sheriff N Dodoo, Ivor J Benjamin
Genomic insights and analyses of Mendelian hypertension (HTN) syndromes and Genome-Wide Association study (GWAS) on essential hypertension have contributed to the depth of understanding of the genetics origins of hypertension. Mendelian syndromes are important for the field, since such knowledge leads to specific insights about disease pathogenesis and the potential for precision medicine. The clinical impact of findings of on essential hypertension is continuously evolving, and the insights accrued will refine efforts to combat the societal impact of hypertension...
May 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/28403029/secular-trends-in-the-physical-fitness-of-united-states-army-recruits-on-entry-to-service-1975-2013
#20
Joseph Knapik, Marilyn Sharp, Ryan A Steelman
A systematic literature search was conducted to identify and analyze articles that reported on physical fitness of new United States (US) Army recruits. The National Library of Medicine's PubMed and the Defense Technical Information Center, were searched using the keywords {military personnel OR trainee OR recruit OR soldier} AND {physical fitness OR strength OR endurance OR flexibility OR balance OR coordination OR muscle contraction OR running OR exercise OR physical conditioning}. Reference lists of obtained articles and contact with authors enhanced the search...
April 11, 2017: Journal of Strength and Conditioning Research
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