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https://www.readbyqxmd.com/read/28815725/p2y6-regulates-cytoskeleton-reorganization-and-cell-migration-of-c2c12-myoblasts-via-rock-pathway
#1
Wei Wang, Mengjie Chen, Yingna Gao, Xianmin Song, Hongliang Zheng, Kaiyong Zhang, Bimeng Zhang, Donghui Chen
Migration of skeletal muscle precursor cells is required for limb muscle development and skeletal muscle repair. This study aimed to examine the role of P2Y6 receptor in C2C12 myoblasts migration. C2C12 myoblasts were treated with P2Y6 agonist UDP, P2Y6 antagonist MRS2578, Ca(2+) channel blocker BTP2, or ROCK inhibitor GSK269962 or Y27632, and the migration ability of C2C12 cells was assessed by wound healing assay. The cellular Ca(2+) content was analyzed with fluo-4 probe and the activation of ROCK (phosphorlyation of LIMK and cofilin) was assayed by western blot...
August 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28807889/activity-trackers-implement-different-behavior-change-techniques-for-activity-sleep-and-sedentary-behaviors
#2
Mitch Duncan, Beatrice Murawski, Camille E Short, Amanda L Rebar, Stephanie Schoeppe, Stephanie Alley, Corneel Vandelanotte, Morwenna Kirwan
BACKGROUND: Several studies have examined how the implementation of behavior change techniques (BCTs) varies between different activity trackers. However, activity trackers frequently allow tracking of activity, sleep, and sedentary behaviors; yet, it is unknown how the implementation of BCTs differs between these behaviors. OBJECTIVE: The aim of this study was to assess the number and type of BCTs that are implemented by wearable activity trackers (self-monitoring systems) in relation to activity, sleep, and sedentary behaviors and to determine whether the number and type of BCTs differ between behaviors...
August 14, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28801304/how-accurate-is-your-activity-tracker-a-comparative-study-of-step-counts-in-low-intensity-physical-activities
#3
Parastoo Alinia, Chris Cain, Ramin Fallahzadeh, Armin Shahrokni, Diane Cook, Hassan Ghasemzadeh
BACKGROUND: As commercially available activity trackers are being utilized in clinical trials, the research community remains uncertain about reliability of the trackers, particularly in studies that involve walking aids and low-intensity activities. While these trackers have been tested for reliability during walking and running activities, there has been limited research on validating them during low-intensity activities and walking with assistive tools. OBJECTIVE: The aim of this study was to (1) determine the accuracy of 3 Fitbit devices (ie, Zip, One, and Flex) at different wearing positions (ie, pants pocket, chest, and wrist) during walking at 3 different speeds, 2...
August 11, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28800273/assessing-the-impact-of-a-remote-digital-coaching-engagement-program-on-patient-reported-outcomes-in-asthma
#4
Mazi Rasulnia, Billy Stephen Burton, Robert P Ginter, Tracy Y Wang, Roy Alton Pleasants, Cynthia L Green, Njira Lugogo
BACKGROUND: Low adherence and poor outcomes provide opportunity for digital coaching to engage patients with uncontrolled asthma in their care to improve outcomes. OBJECTIVES: To examine the impact of a remote digital coaching program on asthma control and patient experience. METHODS: We recruited 51 adults with uncontrolled asthma, denoted by albuterol use of > 2 times per week and/or exacerbations requiring corticosteroids, and applied a 12-week patient-centered remote digital coaching program using a combination of educational pamphlets, symptom trackers, best peak flow establishment, physical activity, and dietary counseling, as well as coaches who implemented emotional enforcement  to motivate disease self-management through telephone, text, and email...
August 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28790910/hybrid-brain-computer-interface-techniques-for-improved-classification-accuracy-and-increased-number-of-commands-a-review
#5
REVIEW
Keum-Shik Hong, Muhammad Jawad Khan
In this article, non-invasive hybrid brain-computer interface (hBCI) technologies for improving classification accuracy and increasing the number of commands are reviewed. Hybridization combining more than two modalities is a new trend in brain imaging and prosthesis control. Electroencephalography (EEG), due to its easy use and fast temporal resolution, is most widely utilized in combination with other brain/non-brain signal acquisition modalities, for instance, functional near infrared spectroscopy (fNIRS), electromyography (EMG), electrooculography (EOG), and eye tracker...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28789636/drug-persistence-and-need-for-dose-intensification-to-adalimumab-therapy-the-importance-of-therapeutic-drug-monitoring-in-inflammatory-bowel-diseases
#6
Lorant Gonczi, Zsuzsanna Kurti, Mariann Rutka, Zsuzsanna Vegh, Klaudia Farkas, Barbara D Lovasz, Petra A Golovics, Krisztina B Gecse, Balazs Szalay, Tamas Molnar, Peter L Lakatos
BACKGROUND: Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with inflammatory bowel disease (IBD) who lose response to anti-TNF therapy. Our aim was to evaluate the frequency and predictive factors of loss of response (LOR) to adalimumab using TDM in IBD patients. METHODS: One hundred twelve IBD patients (with 214 TDM measurements, CD/UC 84/28, male/female 50/62, mean age CD/UC: 36/35 years) were enrolled in this consecutive cohort from two referral centres in Hungary...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28755778/developing-a-fitbit-supported-lifestyle-physical-activity-intervention-for-depressed-alcohol-dependent-women
#7
Ana M Abrantes, Claire E Blevins, Cynthia L Battle, Jennifer P Read, Alan L Gordon, Michael D Stein
PURPOSE: Women in alcohol treatment are more likely to relapse when in unpleasant, negative emotional states. Given the demonstrated benefits of exercise for decreasing depression, negative affect, and urges to drink, helping women engage in a lifestyle physical activity (LPA) intervention in early recovery may provide them a tool they can utilize "in the moment" in order to cope with negative emotional states and alcohol craving when relapse risk is highest. New digital fitness technologies (e...
September 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28740413/dose-ranging-pilot-randomized-trial-of-amino-acid-mixture-combined-with-physical-activity-promotion-for-reducing-abdominal-fat-in-overweight-adults
#8
Hiroyuki Sasai, Keisuke Ueda, Takehiko Tsujimoto, Hiroyuki Kobayashi, Chiaki Sanbongi, Shuji Ikegami, Yoshio Nakata
OBJECTIVE: The objective of this study was to determine the effective dose of an amino acid mixture comprising arginine, alanine, and phenylalanine combined with physical activity promotion in reducing abdominal fat among overweight adults. METHODS: A 12-week randomized, double-blind, placebo-controlled, dose-ranging, pilot trial was conducted in Mito, Japan, from January through April 2016, and the data were analyzed from May through November 2016. The study participants were 35 overweight adults, aged 20-64 years, with no regular exercise habit...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28729927/fatigue-and-cognition-pupillary-responses-to-problem-solving-in-early-multiple-sclerosis-patients
#9
Sigrid A de Rodez Benavent, Gro O Nygaard, Hanne F Harbo, Siren Tønnesen, Piotr Sowa, Nils I Landrø, Marte Wendel-Haga, Lars Etholm, Kristian B Nilsen, Liv Drolsum, Emilia Kerty, Elisabeth G Celius, Bruno Laeng
INTRODUCTION: In early multiple sclerosis (MS) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these symptoms in MS is unknown. In theory, an altered regulation of central neuropeptides can lead to changes in regulation of autonomic function, cognitive difficulties, and fatigue. Direct measurements of central neuropeptides are difficult to perform, but measurements of the eye pupil can be used as a reliable proxy of function...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28726975/use-of-an-activity-tracker-to-test-for-a-possible-correlation-of-resting-heart-rate-with-life-events-an-n-of-1-study-of-participant-provided-data
#10
Paul Cooper, Nilmini Wickramasinghe Deakin Edu Au
No abstract text is available yet for this article.
July 19, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28724509/youth-oriented-activity-trackers-comprehensive-laboratory-and-field-based-validation
#11
John R Sirard, Brittany Masteller, Patty S Freedson, Albert Mendoza, Amanda Hickey
BACKGROUND: Commercial activity trackers are growing in popularity among adults and some are beginning to be marketed to children. There is, however, a paucity of independent research examining the validity of these devices to detect physical activity of different intensity levels. OBJECTIVES: The purpose of this study was to determine the validity of the output from 3 commercial youth-oriented activity trackers in 3 phases: (1) orbital shaker, (2) structured indoor activities, and (3) 4 days of free-living activity...
July 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28714614/-wearable-activity-trackers-are-watching-you
#12
Mathias Tschopp
A growing number of people are using wearable activity trackers, collecting a wide array of parameters including vital signs. This data collection, and the occasional abnormal value, will inevitably raise questions in the doctor's office. In order to correctly answer and address potential concerns, physicians should get familiar with those devices' characteristics, prospects and limitations in a medical setting. This article is an introduction to this topic and offers some insights as to how best handle patients' expectations...
March 1, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28706104/use-of-a-mobile-social-networking-intervention-for-weight-management-a-mixed-methods-study-protocol
#13
Liliana Laranjo, Annie Y S Lau, Paige Martin, Huong Ly Tong, Enrico Coiera
INTRODUCTION: Obesity and physical inactivity are major societal challenges and significant contributors to the global burden of disease and healthcare costs. Information and communication technologies are increasingly being used in interventions to promote behaviour change in diet and physical activity. In particular, social networking platforms seem promising for the delivery of weight control interventions.We intend to pilot test an intervention involving the use of a social networking mobile application and tracking devices (Fitbit Flex 2 and Fitbit Aria scale) to promote the social comparison of weight and physical activity, in order to evaluate whether mechanisms of social influence lead to changes in those outcomes over the course of the study...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28684384/a-bit-of-fit-minimalist-intervention-in-adolescents-based-on-a-physical-activity-tracker
#14
Jeffrey Gaudet, François Gallant, Mathieu Bélanger
BACKGROUND: Only 5% of Canadian youth meet the recommended 60 minutes of moderate to vigorous physical activity (MVPA) per day, with leisure time being increasingly allocated to technology usage. Direct-to-consumer mHealth devices that promote physical activity, such as wrist-worn physical activity trackers, have features with potential appeal to youth. OBJECTIVE: The primary purpose of this study was to determine whether a minimalist physical activity tracker-based intervention would lead to an increase in physical activity in young adolescents...
July 6, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28682659/physical-activity-of-nurse-clinical-practitioners-and-managers
#15
Areeya Jirathananuwat, Krit Pongpirul
BACKGROUND: This study was aimed (1) to compare the level of physical activity (PA) between working and non-working hours and (2) to compare the level of PA during working hours of nurse clinical practitioners (NCP) with that of nurse managers (NM). METHODS: This cross-sectional survey was conducted at a Thai university hospital from October 2015 to March 2016. All randomly selected participants wore an activity tracker on their hip for five days, except during bathing and sleeping periods to record step counts and time points...
July 6, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28666215/just-look-away-gaze-aversions-as-an-overt-attentional-disengagement-mechanism
#16
Dekel Abeles, Shlomit Yuval-Greenberg
During visual exploration of a scene, the eye-gaze tends to be directed toward more salient image-locations, containing more information. However, while performing non-visual tasks, such information-seeking behavior could be detrimental to performance, as the perception of irrelevant but salient visual input may unnecessarily increase the cognitive-load. It would be therefore beneficial if during non-visual tasks, eye-gaze would be governed by a drive to reduce saliency rather than maximize it. The current study examined the phenomenon of gaze-aversion during non-visual tasks, which is hypothesized to act as an active avoidance mechanism...
June 27, 2017: Cognition
https://www.readbyqxmd.com/read/28660095/development-of-the-fitsight-fitness-tracker-to-increase-time-outdoors-to-prevent-myopia
#17
Pavan K Verkicharla, Dharani Ramamurthy, Quang Duc Nguyen, Xinquan Zhang, Suan-Hui Pu, Rahul Malhotra, Truls Ostbye, Ecosse L Lamoureux, Seang-Mei Saw
PURPOSE: To develop a fitness tracker (FitSight) to encourage children to increase time spent outdoors. To evaluate the wear pattern for this tracker and outdoor time pattern by estimating light illumination levels among children. METHODS: The development of the FitSight fitness tracker involved the designing of two components: (1) the smartwatch with custom-made FitSight watch application (app) to log the instant light illuminance levels the wearer is exposed to, and (2) a companion smartphone app that synchronizes the time outdoors recorded by the smartwatch to smartphone via Bluetooth communication...
June 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28659281/diverse-roads-to-relapse-a-discriminative-cue-signaling-cocaine-availability-is-more-effective-in-renewing-cocaine-seeking-in-goal-trackers-than-sign-trackers-and-depends-on-basal-forebrain-cholinergic-activity
#18
Kyle K Pitchers, Kyra B Phillips, Jonte L Jones, Terry E Robinson, Martin Sarter
Stimuli associated with taking drugs are notorious instigators of relapse. There is, however, considerable variation in the motivational properties of such stimuli, both as a function of the individual and the nature of the stimulus. The behavior of some individuals (sign trackers, STs) is especially influenced by cues paired with reward delivery, perhaps because they are prone to process information via dopamine-dependent, cue-driven, incentive salience systems. Other individuals (goal trackers, GTs) are better able to incorporate higher-order contextual information, perhaps because of better executive/attentional control over behavior, which requires frontal cortical cholinergic activity...
July 26, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28659255/mobile-device-accuracy-for-step-counting-across-age-groups
#19
François Modave, Yi Guo, Jiang Bian, Matthew J Gurka, Alice Parish, Megan D Smith, Alexandra M Lee, Thomas W Buford
BACKGROUND: Only one in five American meets the physical activity recommendations of the Department of Health and Human Services. The proliferation of wearable devices and smartphones for physical activity tracking has led to an increasing number of interventions designed to facilitate regular physical activity, in particular to address the obesity epidemic, but also for cardiovascular disease patients, cancer survivors, and older adults. However, the inconsistent findings pertaining to the accuracy of wearable devices for step counting needs to be addressed, as well as factors known to affect gait (and thus potentially impact accuracy) such as age, body mass index (BMI), or leading arm...
June 28, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28652228/a-community-based-physical-activity-counselling-program-for-people-with-knee-osteoarthritis-feasibility-and-preliminary-efficacy-of-the-track-oa-study
#20
Linda C Li, Eric C Sayre, Hui Xie, Cam Clayton, Lynne M Feehan
BACKGROUND: Physical activity can improve health outcomes in people with knee osteoarthritis (OA); however, participation in physical activity is very low in this population. OBJECTIVE: The objective of our study was to assess the feasibility and preliminary efficacy of the use of wearables (Fitbit Flex) and telephone counselling by a physical therapist (PT) for improving physical activity in people with a physician-confirmed diagnosis of knee OA, or who have passed 2 validated criteria for early OA...
June 26, 2017: JMIR MHealth and UHealth
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