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https://www.readbyqxmd.com/read/29232802/-sarcomatoid-urothelial-carcinoma-of-the-bladder-including-an-osteosarcoma-element
#1
Kouzaburou Tanuma, Koji Kawai, Haruki Tsuchiya, Yoshitaka Matsumoto, Shuya Kandori, Takahiro Kojima, Tomokazu Kimura, Akira Joraku, Jun Miyazaki, Hiroyuki Nishiyama, Akiko Sakata
A 68-year-old Japanese man was referred to Tsukuba University Hospital for bladder cancer treatment. He had undergone a transurethral resection of a bladder tumor (TURBT) at a local hospital, but the pathological specimen did not contain muscle layer. Abdominal computed tomography (CT) and magnetic resonance imaging revealed a 3 cm non-papillary bladder tumor with muscle invasion, but there was no apparent calcification. The patient underwent re-TURBT at our hospital for diagnosis and staging. A non-papillary pedunculated tumor was identified in the bladder dome, and it contained a small papillary part...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29232800/-a-case-of-fulminant-hepatitis-after-administration-of-abiraterone-acetate
#2
Satoru Yumiba, Kazuhiko Komori, Toshichika Iwanishi, Youhei Koida, Masao Kobayashi, Yutaka Ono
A 77-year-old man with castration-resistant prostate cancer (CRPC) received abiraterone acetate in October 2014. He visited our outpatient clinic because of general malaise and anorexia 27 days after starting abiraterone acetate. The lab test showed hepatic dysfunction (aspartate transaminase, AST 440 U/l, alanine transaminase, ALT 420 U/l) and the elevation of liver enzymes continued on the next day even after stopping abiraterone acetate. Three days later, he was hospitalized due to severe elevation of liver enzymes (AST 1,171 U/l, ALT 1,487 U/l) , and the decreased prothrombin activity (60...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29232796/-four-cases-of-bacteremia-caused-by-helicobacter-cinaedi-in-the-urological-ward-at-about-the-same-time
#3
Yoshiki Hiyama, Satoshi Takahashi, Naotaka Nishiyama, Mami Nakae, Satoshi Fujii, Masaaki Shinagawa, Naoya Masumori
Here we report the outbreak of bacteremia caused by Helicobacter cinaedi (H. cinaedi) in the urology ward. Case 1 was a man in his seventies with prostate cancer. Bacteremia caused by H. cinaedi developed 6 days after robot-assisted radical prostatectomy. Case 2 was a man in his sixties with small cell carcinoma of the prostate. Bacteremia developed at 5 days of docetaxel therapy. Case 3 was a man in his fifties with left renal pelvis carcinoma. Bacteremia developed 3 days after laparoscopic left nephroureterectomy...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29232725/value-of-contrast-enhanced-ultrasound-quantification-criteria-for-identifying-patients-not-responding-to-bevacizumab-based-therapy-for-colorectal-liver-metastases
#4
François Tranquart, Paul-Armand Dujardin, Olivier Bouché, Claude Marcus, Christophe Borg, Philippe Manzoni, Jean-Yves Douillard, Catherine Labbe-Devilliers, Eric Terrebonne, Denis Smith, Herve Trillaud, Olivier Capitain, Cristophe Aubé, Jean-Philippe Spano, Olivier Lucidarme, Aurélie Ferru, Jean-Pierre Tasu, Sylvain Manfredi, Aurore Bleuzen, Julie Léger, Thierry Lecomte
Purpose To evaluate changes in tumor vascularization parameters based on contrast-enhanced ultrasound (CEUS) quantification criteria of at least one visible liver metastasis as an early predictor of non-response to chemotherapy, including bevacizumab for colorectal cancer (CRC) liver metastases. Materials and Methods This multicenter prospective study included patients who received first-line bevacizumab-based chemotherapy. Tumor enhancement measured using CEUS within one liver metastasis and in relation to the surrounding healthy liver was quantified within 8 days before the first infusion of bevacizumab (E0), 24 hours after the end of the first infusion of bevacizumab (E1), in the 24 hours before the 2nd and 3 rd infusion of bevacizumab on day 15 (E2) and day 30 (E3), respectively, and after 2 months of treatment (E4)...
December 12, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29232656/targeting-oral-cancer-epigenome-via-lsd1
#5
Manish V Bais
No abstract text is available yet for this article.
December 11, 2017: Aging
https://www.readbyqxmd.com/read/29232637/copper-ii-complexes-based-on-tripodal-pyrazolyl-amines-synthesis-structure-magnetic-properties-and-anticancer-activity
#6
Salah S Massoud, Febee R Louka, Gerard T Ducharme, Roland C Fischer, Franz A Mautner, Ján Vančo, Radovan Herchel, Zdeněk Dvořák, Zdeněk Trávníček
The Cu(II) complexes [Cu(bpdmpz)Cl]ClO4 (1), [Cu(bdmpzp)Cl]ClO4 (2-ClO4), [Cu(bdmpzp)Cl]PF6 (2-PF6) and [Cu(tdmpza)Cl]ClO4 (3), bpdmpzp=[bis[((2-pyridylmethyl)-di(3,5-dimethyl-1H-pyrazolyl)methyl)]amine, bdmpzp=[bis((di(3,5-dimethyl-1H-pyrazolyl)methyl)-(2-pyridylmethyl)]amine and tdmpza=tris[di(3,5-dimethyl-1H-pyrazolyl)-methyl)]amine were synthesized and characterized by elemental analysis, magnetic and conductivity measurements, electrospray-ionization mass spectrometry, infrared and electronic spectroscopy, and X-ray crystallography...
December 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29232633/carbazole-alkaloids-from-clausena-hainanensis-with-their-potential-antiproliferative-activities
#7
Yan-Lei Ma, Yan-Ping Liu, Chao Zhang, Wan-Hui Zhao, Shi Shi, Dan-Nv He, Pan Zhang, Xiao-Hong Liu, Ting-Ting Han, Yan-Hui Fu
Five new carbazole alkaloids, clausehainanines A-E (1-5), together with seven known analogues (6-12) were isolated from the stems and leaves of C. hainanensis. Their structures were elucidated by extensive spectroscopic methods. Among them, compounds 1-5 were an unusual type of carbazole alkaloids, possessing diverse isopentenyl derivatives as substituents at C-2. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29232628/epithelial-plasticity-in-the-mammary-gland
#8
REVIEW
Lindsey Seldin, Armelle Le Guelte, Ian G Macara
Many epithelial tissues rely on multipotent stem cells for the proper development and maintenance of their diverse cell lineages. Nevertheless, the identification of multipotent stem cell populations within the mammary gland has been a point of contention over the past decade. In this review, we provide a critical overview of the various lineage-tracing studies performed to address this issue and conclude that although multipotent stem cells exist in the embryonic mammary placode, the postnatal mammary gland instead contains distinct unipotent progenitor populations that contribute to stage-specific development and homeostasis...
December 9, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29232588/bioactive-products-from-singlet-oxygen-photooxygenation-of-cannabinoids
#9
Ahmed Galal Osman, Khaled M Elokely, Vivek K Yadav, Paulo Carvalho, Mohamed Radwan, Desmond Slade, Waseem Gul, Shabana Khan, Olivia R Dale, Afeef S Husni, Michael L Klein, Stephen J Cutler, Samir A Ross, Mahmoud A ElSohly
Photooxygenation of Δ8 tetrahydrocannabinol (Δ8-THC), Δ9 tetrahydrocannabinol (Δ9-THC), Δ9 tetrahydrocannabinolic acid (Δ9-THCA) and some derivatives (acetate, tosylate and methyl ether) yielded 24 oxygenated derivatives, 18 of which were new and 6 were previously reported, including allyl alcohols, ethers, quinones, hydroperoxides, and epoxides. Testing these compounds for their modulatory effect on cannabinoid receptors CB1 and CB2 led to the identification of 7 and 21 as CB1 partial agonists with Ki values of 0...
November 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232585/synthesis-of-new-triterpenic-monomers-and-dimers-as-potential-antiproliferative-agents-and-their-molecular-docking-studies
#10
Aasim Saeed, Hidayat Hussain, Umair Shamraiz, Najeeb Ur Rehman, Husain Yar Khan, Amin Badshah, Lucie Heller, René Csuk, Majid Ali, Ajmal Khan, Ahmed Al-Harrasi
In the current investigation, new monomers of myrrhanone B and lupeolic acid were prepared via reaction of triterpenic acids with linkers in the presence of K2CO3. In addition, new bis-myrrhanone B homodimers, myrrhanone B-myrrhanol B heterodimers, and bis-myrrhanone β-boswellic acids heterodimer were prepared. Evaluation of these compounds on the proliferation of four different human cancer cell lines, viz., FaDu (pharynx carcinoma), A2780 (ovarian carcinoma), HT29 (colon adenocarcinoma) and A375 (malignant melanoma) has been performed...
December 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232583/development-of-novel-bis-pyrazole-derivatives-as-antitumor-agents-with-potent-apoptosis-induction-effects-and-dna-damage
#11
Hong Dai, Shushan Ge, Jing Guo, Shi Chen, Meiling Huang, Jiaying Yang, Siyu Sun, Yong Ling, Yujun Shi
A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor effects in vitro and in vivo were investigated. Several compounds displayed good antiproliferative activity with IC50 values in low-micromolar range against three human cancer cell lines in vitro, superior to 5-FU. The most potent compound 10M selectively inhibited human hepatocellular carcinoma cells but not non-tumor liver cell proliferation in vitro, and significantly triggered SMMC-7721 cell apoptosis by cleavage of both PARP and caspase-3 in a concentration-dependent manner...
December 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232581/homo-and-heteroleptic-pt-ii-complexes-of-onn-donor-hydrazone-and-4-picoline-a-synthetic-structural-and-detailed-mechanistic-anticancer-investigation
#12
Faiz-Ur Rahman, Muhammad Zeeshan Bhatti, Amjad Ali, Hong-Quan Duong, Yao Zhang, Bo Yang, Satish Koppireddi, Yuejian Lin, Hui Wang, Zhan-Ting Li, Dan-Wei Zhang
Two series of homoleptic Pt(II)(hydrazone)Cl (C1a-C5a) and heteroleptic Pt(II)(hydrazone)(4-picoline). BF4 (C1b-C5b) complexes were prepared and characterized by 1H, 13C, 19F NMR and HR ESI-MS. Structure of C2b was confirmed by single crystal X-ray analysis. These complexes were studied for their in vitro anticancer activities in human multiple cancer cells including breast (MCF-7), liver (HepG2), lung (H460), colon (HCT116) and cervical (Hela) cancers. C1a-C5a and C1b-C5b showed considerable anticancer effect...
November 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232580/design-and-synthesis-of-novel-quinacrine-1-3-thiazinan-4-one-hybrids-for-their-anti-breast-cancer-activity
#13
V Raja Solomon, Sheetal Pundir, Hoang-Thanh Le, Hoyun Lee
In an attempt to develop effective and safe anticancer agents, we designed, synthesized and examined 23 novel quinacrine (QC) derivatives by combining the 9-aminoacridine scaffold and the [1,3]thiazinan-4-ones group. Most of these hybrids showed strong anticancer activities, among which 3-(3-(6-chloro-2-methoxyacridin-9-ylamino)propyl)-2-(thiophen-2-yl)-1,3-thiazinan-4-one (25; VR151) effectively killed many different cancer cell types, including eight breast cancer cell lines with different genetic background, two prostate cancer and two lung cancer cell lines...
December 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232579/structure-based-identification-of-a-nedd8-activating-enzyme-inhibitor-via-drug-repurposing
#14
Ke-Jia Wu, Hai-Jing Zhong, Guodong Li, Chenfu Liu, Hui-Min David Wang, Dik-Lung Ma, Chung-Hang Leung
NEDD8-activating enzyme (NAE) is an essential player of the NEDD8 conjugation pathway that regulates protein degradation. Meanwhile, drug repurposing is a cost-efficient strategy to identify new therapeutic uses for existing scaffolds. In this report, mitoxantrone (1) was repurposed as an inhibitor of NAE by virtual screening of an FDA-approved drug database. Compound 1 inhibited NAE activity in cell-free and cell-based systems with high selectivity and was competitive with ATP. Furthermore, compound 1 induced apoptosis of colorectal adenocarcinoma cancer cells through inhibiting the degradation of the neddylation substrate p53...
December 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232568/prior-systemic-treatment-increased-the-incidence-of-somatic-mutations-in-metastatic-breast-cancer
#15
Takeo Fujii, Naoko Matsuda, Miho Kono, Kenichi Harano, Huiqin Chen, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri, Aysegul A Sahin, Chetna Wathoo, Aron Y Joon, Debu Tripathy, Funda Meric-Bernstam, Naoto T Ueno
BACKGROUND: Understanding the biology of breast cancer is important for guiding treatment strategies and revealing resistance mechanisms. Our objectives were to investigate the relationship between previous systemic therapy exposure and mutational spectrum in metastatic breast cancer and to identify clinicopathological factors associated with identified frequent somatic mutations. METHODS: Archival tissues of patients with metastatic breast cancer were subjected to hotspot molecular testing by next-generation sequencing...
December 9, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29232558/high-throughput-phenotyping-of-lung-cancer-somatic-mutations
#16
Alice H Berger, Angela N Brooks, Xiaoyun Wu, Yashaswi Shrestha, Candace Chouinard, Federica Piccioni, Mukta Bagul, Atanas Kamburov, Marcin Imielinski, Larson Hogstrom, Cong Zhu, Xiaoping Yang, Sasha Pantel, Ryo Sakai, Jacqueline Watson, Nathan Kaplan, Joshua D Campbell, Shantanu Singh, David E Root, Rajiv Narayan, Ted Natoli, David L Lahr, Itay Tirosh, Pablo Tamayo, Gad Getz, Bang Wong, John Doench, Aravind Subramanian, Todd R Golub, Matthew Meyerson, Jesse S Boehm
No abstract text is available yet for this article.
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232557/myeloid-cell-derived-reactive-oxygen-species-induce-epithelial-mutagenesis
#17
Özge Canli, Adele M Nicolas, Jalaj Gupta, Fabian Finkelmeier, Olga Goncharova, Marina Pesic, Tobias Neumann, David Horst, Martin Löwer, Ugur Sahin, Florian R Greten
Increased oxidative stress has been suggested to initiate and promote tumorigenesis by inducing DNA damage and to suppress tumor development by triggering apoptosis and senescence. The contribution of individual cell types in the tumor microenvironment to these contrasting effects remains poorly understood. We provide evidence that during intestinal tumorigenesis, myeloid cell-derived H2O2 triggers genome-wide DNA mutations in intestinal epithelial cells to stimulate invasive growth. Moreover, increased reactive oxygen species (ROS) production in myeloid cells initiates tumor growth in various organs also in the absence of a carcinogen challenge in a paracrine manner...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232555/mtorc2-promotes-tumorigenesis-via-lipid-synthesis
#18
Yakir Guri, Marco Colombi, Eva Dazert, Sravanth K Hindupur, Jason Roszik, Suzette Moes, Paul Jenoe, Markus H Heim, Isabelle Riezman, Howard Riezman, Michael N Hall
Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC). Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepatic mTORC2 promotes de novo fatty acid and lipid synthesis, leading to steatosis and tumor development. In particular, mTORC2 stimulated sphingolipid (glucosylceramide) and glycerophospholipid (cardiolipin) synthesis...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232554/genomic-aberrations-that-activate-d-type-cyclins-are-associated-with-enhanced-sensitivity-to-the-cdk4-and-cdk6-inhibitor-abemaciclib
#19
Xueqian Gong, Lacey M Litchfield, Yue Webster, Li-Chun Chio, Swee Seong Wong, Trent R Stewart, Michele Dowless, Jack Dempsey, Yi Zeng, Raquel Torres, Karsten Boehnke, Cecilia Mur, Carlos Marugán, Carmen Baquero, Chunping Yu, Steven M Bray, Isabella H Wulur, Chen Bi, Shaoyou Chu, Hui-Rong Qian, Philip W Iversen, Farhana F Merzoug, Xiang S Ye, Christoph Reinhard, Alfonso De Dios, Jian Du, Charles W Caldwell, María José Lallena, Richard P Beckmann, Sean G Buchanan
Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6 inhibitors have shown promising clinical activity in breast cancer and lymphomas, but it is not clear which additional Rb-positive cancers might benefit from these agents. No systematic survey to compare relative sensitivities across tumor types and define molecular determinants of response has been described. We report a subset of cancers highly sensitive to CDK4/6 inhibition and characterized by various genomic aberrations known to elevate D-cyclin levels and describe a recurrent CCND1 3'UTR mutation associated with increased expression in endometrial cancer...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232553/synthetic-lethality-of-combined-bcl-2-inhibition-and-p53-activation-in-aml-mechanisms-and-superior-antileukemic-efficacy
#20
Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D Leverson, Gwen Nichols, John C Reed, Marina Konopleva, Michael Andreeff
Evasion of apoptosis is a hallmark of cancer. Bcl-2 and p53 represent two important nodes in apoptosis signaling pathways. We find that concomitant p53 activation and Bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemia (AML). Mechanistically, p53 activation negatively regulates the Ras/Raf/MEK/ERK pathway and activates GSK3 to modulate Mcl-1 phosphorylation and promote its degradation, thus overcoming AML resistance to Bcl-2 inhibition...
December 11, 2017: Cancer Cell
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