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https://www.readbyqxmd.com/read/29925110/cervical-cancer-registered-in-two-developed-regions-from-brazil-upper-limit-of-reachable-results-from-opportunistic-screening
#1
Julio Cesar Teixeira, Carlos Afonso Maestri, Helymar da Costa Machado, Luiz Carlos Zeferino, Newton Sérgio de Carvalho
OBJECTIVE:  The aim of this study was to assess the time trends and pattern of cervical cancer diagnosed in the period from 2001 to 2012 by means of an opportunistic screening program from two developed regions in Brazil. METHODS:  An observational study analyzing 3,364 cancer records ( n  = 1,646 from Campinas and n  = 1,718 from Curitiba region) available in hospital-based cancer registries was done. An additional 1,836 records of CIN3/AIS from the region of Campinas was analyzed...
June 20, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29925109/external-quality-monitoring-of-the-cervical-cytopathological-exams-in-the-rio-de-janeiro-city
#2
Vânia Stiepanowez de Oliveira Rocha, Solange da Silva Malfacini, Alex Moreira Gomes, Cláudia Ramos Marques da Rocha
OBJECTIVE:  To discuss the implementation and contributions of the External Quality Monitoring in the city of Rio de Janeiro and to analyze the performance of the main providers of cervical cytopathology in this city from September 2013 to March 2017, here referred to as "Alpha laboratory" and "Beta laboratory." METHODS:  Observational, cross-sectional, retrospective study using information from the Cervical Cancer Control Information System (SISCOLO, in the Portuguese acronym), municipal coordination module, External Quality Monitoring report...
June 20, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29925100/six-new-neo-clerodane-diterpenoids-from-aerial-parts-of-scutellaria-barbata-and-their-cytotoxic-activities
#3
Guo-Chun Yang, Jia-Hui Hu, Bing-Long Li, Huan Liu, Jia-Yue Wang, Li-Xin Sun
Six new neo-clerodane diterpenoids (1: -6: ), scutebatas X - Z, A1 -C1 , along with twelve known ones (7: -18: ) were obtained via the phytochemical investigation of the aerial parts of Scutellaria barbata . Their structures were established by detailed spectroscopic analysis. The absolute configurations of 1: and 2: , as the representative members of this type, were identified based on a circular dichroic exciton chirality method. Moreover, in vitro cytotoxicity of compounds 1: -6: were evaluated against three human cancer cell lines (SGC-7901, MCF-7, and A-549) using the MTT method...
June 20, 2018: Planta Medica
https://www.readbyqxmd.com/read/29925063/targeting-shp-1-2-and-ship-pathways-a-novel-strategy-for-cancer-treatment
#4
REVIEW
Wolfram C M Dempke, Peter Uciechowski, Klaus Fenchel, Timothy Chevassut
Well-balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), are critical for a wide range of cellular processes including growth, differentiation, metabolism, migration, and survival. Aberrant tyrosine phosphorylation, as a result of a perturbed balance between the activities of PTKs and PTPs, is linked to the pathogenesis of numerous human diseases, including cancer, suggesting that PTPs may be innovative molecular targets for cancer treatment...
June 20, 2018: Oncology
https://www.readbyqxmd.com/read/29925044/a-systematic-review-of-patient-reported-outcomes-in-phase-ii-or-iii-clinical-trials-of-myelodysplastic-syndromes-and-acute-myeloid-leukemia
#5
REVIEW
Ashley Leak Bryant, Sarah W Drier, Sejin Lee, Antonia V Bennett
The purpose of this systematic literature review was to identify clinical trials of MDS and AML that included patient-reported outcome (PRO) instruments, and to summarize the symptom and other health related quality of life (HRQOL) concepts most frequently assessed and the PRO instruments that were used. Sixteen manuscripts describing 14 distinct trials met all criteria (i.e., phase 2 or 3 clinical trial for MDS or AML which included PRO assessment) and were published between 1996-2017. In trials evaluating anemia, PRO scores showed significant improvement in relevant domains (e...
June 7, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29925043/molecular-characterization-and-putative-pathogenic-pathways-of-tuberous-sclerosis-complex-associated-renal-cell-carcinoma
#6
Jeong Hwan Park, Cheol Lee, Mee Soo Chang, Kwangsoo Kim, Seongmin Choi, Hyunjung Lee, Hyun-Seob Lee, Kyung Chul Moon
Tuberous sclerosis complex-associated renal cell carcinoma (TSC-RCC) has distinct clinical and histopathologic features and is considered a specific subtype of RCC. The genetic alterations of TSC1 or TSC2 are responsible for the development of TSC. In this study, we assessed the mTOR pathway activation and aimed to evaluate molecular characteristics and pathogenic pathways of TSC-RCC. Two cases of TSC-RCC, one from a 31-year-old female and the other from an 8-year-old male, were assessed. The mTOR pathway activation was determined by immunohistochemistry...
June 17, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29925042/sirt2-promotes-the-migration-and-invasion-of-gastric-cancer-through-ras-erk-jnk-mmp-9-pathway-by-increasing-pepck1-related-metabolism
#7
Yang Li, Mingming Zhang, Robert G Dorfman, Yida Pan, Dehua Tang, Lei Xu, Zhenguo Zhao, Qian Zhou, Lixing Zhou, Yuming Wang, Yuyao Yin, Shanshan Shen, Bo Kong, Helmut Friess, Shimin Zhao, Lei Wang, Xiaoping Zou
Metastasis is the most important feature of gastric cancer (GC) and the most widely recognized reason for GC-related deaths. Unfortunately, the underlying mechanism behind this metastasis remains unknown. Mounting evidence suggests the dynamic regulatory role of sirtuin2 (SIRT2), a histone deacetylase (HDAC), in cell migration and invasion. The present study aims to evaluate the biological function of SIRT2 in GC and identify the target of SIRT2 as well as evaluate its therapeutic efficacy. We found that SIRT2 was upregulated in GC tissues compared to adjacent normal tissues, and this was correlated with reduced patient survival...
June 17, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29925032/transition-from-actin-driven-to-water-driven-cell-migration-depends-on-external-hydraulic-resistance
#8
Yizeng Li, Sean X Sun
Cells in vivo can reside in diverse physical and biochemical environments. For example, epithelial cells typically live in a two-dimensional (2D) environment, whereas metastatic cancer cells can move through dense three-dimensional matrices. These distinct environments impose different kinds of mechanical forces on cells and thus potentially can influence the mechanism of cell migration. For example, cell movement on 2D flat surfaces is mostly driven by forces from focal adhesion and actin polymerization, whereas in confined geometries, it can be driven by water permeation...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925031/influence-of-pulsed-electric-fields-and-mitochondria-cytoskeleton-interactions-on-cell-respiration
#9
Ishan Goswami, Justin B Perry, Mitchell E Allen, David A Brown, Michael R von Spakovsky, Scott S Verbridge
Pulsed electric fields with microsecond pulse width (μsPEFs) are used clinically; namely, irreversible electroporation/Nanoknife is used for soft tissue tumor ablation. The μsPEF pulse parameters used in irreversible electroporation (0.5-1 kV/cm, 80-100 pulses, ∼100 μs each, 1 Hz frequency) may cause an internal field to develop within the cell because of the disruption of the outer cell membrane and subsequent penetration of the electric field. An internal field may disrupt voltage-sensitive mitochondria, although the research literature has been relatively unclear regarding whether such disruptions occur with μsPEFs...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925010/the-cancer-genome-atlas-comprehensive-molecular-characterization-of-renal-cell-carcinoma
#10
Christopher J Ricketts, Aguirre A De Cubas, Huihui Fan, Christof C Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A Gibb, Rehan Akbani, Rameen Beroukhim, Donald P Bottaro, Toni K Choueiri, Richard A Gibbs, Andrew K Godwin, Scott Haake, A Ari Hakimi, Elizabeth P Henske, James J Hsieh, Thai H Ho, Rupa S Kanchi, Bhavani Krishnan, David J Kwiatkowski, Wembin Lui, Maria J Merino, Gordon B Mills, Jerome Myers, Michael L Nickerson, Victor E Reuter, Laura S Schmidt, C Simon Shelley, Hui Shen, Brian Shuch, Sabina Signoretti, Ramaprasad Srinivasan, Pheroze Tamboli, George Thomas, Benjamin G Vincent, Cathy D Vocke, David A Wheeler, Lixing Yang, William Y Kim, A Gordon Robertson, Paul T Spellman, W Kimryn Rathmell, W Marston Linehan
No abstract text is available yet for this article.
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29925009/human-organ-chip-models-recapitulate-orthotopic-lung-cancer-growth-therapeutic-responses-and-tumor-dormancy-in-vitro
#11
Bryan A Hassell, Girija Goyal, Esak Lee, Alexandra Sontheimer-Phelps, Oren Levy, Christopher S Chen, Donald E Ingber
No abstract text is available yet for this article.
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29925003/energy-metabolism-rewiring-precedes-uvb-induced-primary-skin-tumor-formation
#12
Mohsen Hosseini, Léa Dousset, Walid Mahfouf, Martin Serrano-Sanchez, Isabelle Redonnet-Vernhet, Samir Mesli, Zeinab Kasraian, Emilie Obre, Marc Bonneu, Stephane Claverol, Marija Vlaski, Zoran Ivanovic, Walid Rachidi, Thierry Douki, Alain Taieb, Anne-Karine Bouzier-Sore, Rodrigue Rossignol, Hamid Reza Rezvani
Although growing evidence indicates that bioenergetic metabolism plays an important role in the progression of tumorigenesis, little information is available on the contribution of reprogramming of energy metabolism in cancer initiation. By applying a quantitative proteomic approach and targeted metabolomics, we find that specific metabolic modifications precede primary skin tumor formation. Using a multistage model of ultraviolet B (UVB) radiation-induced skin cancer, we show that glycolysis, tricarboxylic acid (TCA) cycle, and fatty acid β-oxidation are decreased at a very early stage of photocarcinogenesis, while the distal part of the electron transport chain (ETC) is upregulated...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924973/immune-checkpoint-blockade-across-the-cancer-care-continuum
#13
Beth A Helmink, Pierre-Olivier Gaudreau, Jennifer A Wargo
Four studies recently reported in the New England Journal of Medicine highlight advances in treatment with immune checkpoint blockade across the cancer care continuum. These findings demonstrate efficacy of these agents in the treatment of early and late-stage disease, as monotherapy or in combination, and in addition to-or in place of-standard front-line therapy.
June 19, 2018: Immunity
https://www.readbyqxmd.com/read/29924962/prognostic-value-of-aldehyde-dehydrogenase-1-aldh1-in-invasive-breast-carcinomas
#14
Hale Demir, Ozgecan Dulgar, Bugra Taygun Gulle, Hande Turna, Sennur Ilvan
Aldehyde dehydrogenase 1 (ALDH1) has been identified as a marker of cancer stem cells in breast cancer (BC). Recent studies showed that ALDH1 expression is correlated with poor prognostic parameters and worse clinical outcome in BC. We evaluated ALDH1 expression by immunohistochemistry in a series of 217 invasive BCs and investigated the correlation between ALDH1 expression and clinicopathological parameters, molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] type, and triple-negative BC [TNBC]), and patient survival...
June 11, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924959/immunohistochemical-expression-of-nedd9-e-cadherin-and-%C3%AE-catenin-and-their-prognostic-significance-in-pancreatic-ductal-adenocarcinoma-pdac
#15
Petra Radulović, Božo Krušlin
Extensive research is being conducted to identify novel diagnostic, predictive and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC), as only a few markers have been routinely used so far with limited success. Our aim was to assess the expression of neural precursor cell expressed developmentally down-regulated protein 9 (NEDD9), E-cadherin, and γ-catenin in PDAC in relation to clinicopathological parameters and patient survival. We also investigated if there is a correlation of NEDD9 expression with E-cadherin or γ-catenin...
June 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924958/overexpression-of-mir-361-5p-in-triple-negative-breast-cancer-tnbc-inhibits-migration-and-invasion-by-targeting-rqcd1-and-inhibiting-the-egfr-pi3k-akt-pathway
#16
Jianjun Han, Jingjing Yu, Yuna Dai, Jumei Li, Meiyan Guo, Jingzhen Song, Xuefeng Zhou
Triple-negative breast cancer (TNBC) is the leading cause of cancer-related death in women. Previous studies indicated that miR-361-5p was downregulated in breast cancer, however, the exact effect of miR-361-5p on TNBC requires further investigation. In the present study, we investigated whether miR-361-5p can act as a tumor suppressor by targeting required for cell differentiation 1 homolog (RQCD1) and inhibiting epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway in TNBC...
June 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924955/sodium-thiosulfate-for-protection-from-cisplatin-induced-hearing-loss
#17
Penelope R Brock, Rudolf Maibach, Margaret Childs, Kaukab Rajput, Derek Roebuck, Michael J Sullivan, Véronique Laithier, Milind Ronghe, Patrizia Dall'Igna, Eiso Hiyama, Bénédicte Brichard, Jane Skeen, M Elena Mateos, Michael Capra, Arun A Rangaswami, Marc Ansari, Catherine Rechnitzer, Gareth J Veal, Anna Covezzoli, Laurence Brugières, Giorgio Perilongo, Piotr Czauderna, Bruce Morland, Edward A Neuwelt
Background Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival. Methods We randomly assigned children older than 1 month and younger than 18 years of age who had standard-risk hepatoblastoma (≤3 involved liver sectors, no metastatic disease, and an alpha-fetoprotein level of >100 ng per milliliter) to receive cisplatin alone (at a dose of 80 mg per square meter of body-surface area, administered over a period of 6 hours) or cisplatin plus sodium thiosulfate (at a dose of 20 g per square meter, administered intravenously over a 15-minute period, 6 hours after the discontinuation of cisplatin) for four preoperative and two postoperative courses...
June 21, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29924943/peptidylarginine-deiminase-4-a-nuclear-button-triggering-neutrophil-extracellular-traps-in-inflammatory-diseases-and-aging
#18
Siu Ling Wong, Denisa D Wagner
Peptidylarginine deiminase 4 (PAD4) is a nuclear citrullinating enzyme that is critically involved in the release of decondensed chromatin from neutrophils as neutrophil extracellular traps (NETs). NETs, together with fibrin, are implicated in host defense against pathogens; however, the formation of NETs (NETosis) has injurious effects that may outweigh their protective role. For example, PAD4 activity produces citrullinated neoantigens that promote autoimmune diseases, such as rheumatoid arthritis, to which PAD4 is genetically linked and where NETosis is prominent...
June 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29924914/the-efficacy-of-ultrasound-in-the-follow-up-after-a-negative-sentinel-lymph-node-in-vulvar-cancer-patients-a-prospective-single-center-study
#19
Anne-Floor W Pouwer, Roel D M Mus, Joanna IntHout, Ate G J van der Zee, Johan Bulten, Leon F A G Massuger, Joanne A de Hullu
OBJECTIVE: To determine the efficacy of the addition of an ultrasound of the groins in routine follow-up of patients with vulvar squamous cell carcinoma (SCC) after a negative sentinel lymph node (SLN). DESIGN: Prospective single center study. SETTING: A tertiary expert oncology center for the treatment of vulvar cancer. POPULATION: All vulvar SCC patients with a negative SLN, treated between 2006 and 2014. METHODS: We prospectively collected data of 139 vulvar SCC patients treated with a SLN procedure...
June 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29924913/mir-27b-3p-is-involved-in-doxorubicin-resistance-of-human-anaplastic-thyroid-cancer-cells-via-targeting-ppar%C3%AE
#20
Yuan Xu, Yi-Fan Han, Bing Ye, Yin-Long Zhang, Jian-Da Dong, Shao-Jun Zhu, Jiong Chen
Chemotherapy is one of the most effective forms of cancer treatment. It has been widely used in the treatment of various malignant tumors. In order to investigate molecular mechanisms responsible for the chemoresistance of anaplastic thyroid cancer (ATC), we established the doxorubicin (Dox) resistance of human ATC SW1736 and 8305C cells and named them SW1736/Dox and 8305C/Dox, respectively. We evaluated the expression of various micro-RNAs (miRNAs) between control and Dox-resistant ATC cells and found that the expression of miR-27b-3p was significantly increased in Dox-resistant ATC cells...
June 20, 2018: Basic & Clinical Pharmacology & Toxicology
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