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https://www.readbyqxmd.com/read/28749599/heat-induced-inflammation-and-its-role-in-esophageal-cancer
#1
REVIEW
Mohaddese Maghsudlu, Ehsan Farashahi Yazd
Esophageal cancer as the sixth common cause of cancer death in the world consists of different histological types with various incidence patterns. Among them, esophageal adenocarcinoma and esophageal squamous cell carcinoma are the most prevalent types which also have different causality, cell of origin and risk factors. Since epidemiological studies have announced consumption of hot substances as one of the major risk factors for squamous cell carcinoma, evaluating the effect of this external stress on esophagus cells seems desirable...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28748118/serum-uric-acid-and-acute-kidney-injury-a-mini-review
#2
REVIEW
Kai Hahn, Mehmet Kanbay, Miguel A Lanaspa, Richard J Johnson, A Ahsan Ejaz
Acute kidney injury causes great morbidity and mortality in both the community and hospital settings. Understanding the etiological factors and the pathophysiological principles resulting in acute kidney injury is essential in prompting appropriate therapies. Recently hyperuricemia has been recognized as a potentially modifiable risk factor for acute kidney injury, including that associated with cardiovascular surgery, radiocontrast administration, rhabdomyolysis, and associated with heat stress. This review discussed the evidence that repeated episodes of acute kidney injury from heat stress and dehydration may also underlie the pathogenesis of the chronic kidney disease epidemic that is occurring in Central America (Mesoamerican nephropathy)...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28747872/l-3-n-butylphthalide-protects-hspb8-k141n-mutation-induced-oxidative-stress-by-modulating-the-mitochondrial-apoptotic-and-nrf2-pathways
#3
Xiao-Dong Yang, Zhi-Dong Cen, Hai-Peng Cheng, Kai Shi, Jie Bai, Fei Xie, Hong-Wei Wu, Bei-Bei Li, Wei Luo
Charcot-Marie-Tooth disease (CMT), also known as hereditary motor and sensory neuropathy, is the most common inherited peripheral nerve disorder. Missense mutations, such as K141N, in the small heat shock protein HSPB8 are known to cause distal hereditary motor neuropathy 2A (dHMN2A) or Charcot-Marie-Tooth neuropathy type 2L (CMT2L). However, of critical clinical significance, very few specific therapies for this disease exist. In the present study, we investigated the impact of mutant K141N HSPB8 on mitochondrial distribution and function in a cellular model of CMT2L...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28747868/protective-effect-of-momordica-charantia-water-extract-against-liver-injury-in-restraint-stressed-mice-and-the-underlying-mechanism
#4
Yuanyuan Deng, Qin Tang, Yan Zhang, Ruifen Zhang, Zhencheng Wei, Xiaojun Tang, Mingwei Zhang
Background: Momordica charantia is used in China for its jianghuo (heat-clearing and detoxifying) effects. The concept of shanghuo (the antonym of jianghuo, excessive internal heat) in traditional Chinese medicine is considered a type of stress response of the body. The stress process involves internal organs, especially the liver. Objective: We hypothesized that Momordica charantia water extract (MWE) has a hepatoprotective effect and can protect the body from stress. The aim of this study was to investigate the possible effects of MWE against liver injury in restraint-stressed mice...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28740997/guidelines-for-bystander-first-aid-2016
#5
Jen Heng Pek
Cardiac life support is a form of first aid for cardiac emergencies. However, research and evidence in this field is lacking compared with other forms of first aid. Having identified the common emergencies that are encountered in the hospital, based on the available evidence, we have put together what could be an evidence-based approach to the first aid management of some of these common emergencies, viz. breathlessness, chest pain, allergies, stroke, heat injury, poisoning, unconsciousness, seizures, and trauma situations such as bleeding, wounds, contusions, head injury, burns and fractures...
July 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28740739/a-combined-water-extract-of-frankincense-and-myrrh-alleviates-neuropathic-pain-in-mice-via-modulation-of-trpv1
#6
Danyou Hu, Changming Wang, Fengxian Li, Shulan Su, Niuniu Yang, Yan Yang, Chan Zhu, Hao Shi, Lei Yu, Xiao Geng, Leying Gu, Xiaolin Yuan, Zhongli Wang, Guang Yu, Zongxiang Tang
Frankincense and myrrh are widely used in clinics as a pair of herbs to obtain a synergistic effect for relieving pain. To illuminate the analgesia mechanism of frankincense and myrrh, we assessed its effect in a neuropathic pain mouse model. Transient receptor potential vanilloid 1 (TRPV1) plays a crucial role in neuropathic pain and influences the plasticity of neuronal connectivity. We hypothesized that the water extraction of frankincense and myrrh (WFM) exerted its analgesia effect by modulating the neuronal function of TRPV1...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28738744/pain-profiles-in-a-community-dwelling-population-following-spinal-cord-injury-a-national-survey
#7
Dearbhla Burke, Brona M Fullen, Olive Lennon
CONTEXT: While as many as 60% of patients with spinal cord injury (SCI) develop chronic pain, limited data currently exists on the prevalence and profile of pain post-SCI in community dwelling populations. STUDY DESIGN: A cross-sectional population survey. SETTING: Primary care. PARTICIPANTS: Community dwelling adults with SCI. METHODS: Following ethical approval members registered to a national SCI database (n=1,574) were surveyed...
July 24, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28732925/analysis-of-staphylococcus-aureus-cell-viability-sublethal-injury-and-death-induced-by-synergistic-combination-of-ultrasound-and-mild-heat
#8
Jiao Li, Yuanjie Suo, Xinyu Liao, Juhee Ahn, Donghong Liu, Shiguo Chen, Xingqian Ye, Tian Ding
This study was designed to investigate the combined effects of ultrasound and mild heat on the viability of S. aureus in association with the cell membrane integrity and intracellular enzyme activity. Cells were treated by ultrasound under 55°C for 3, 5, 7, 10, and 15min. The dynamic changes of S. aureus cell viability, sublethal injury and death were evaluated using flow cytometric assay. Microscopies were applied to identify the morphological appearance, ultrastructure and topography of S. aureus. The results showed the membrane damage was synchronous with esterase inhibition during the exposure to sonication, leading to the immediate lethal effect...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732764/vasculitic-peripheral-neuropathy-induced-by-ischemia-reperfusion-in-the-rat-femoral-artery-involves-activation-of-proinflammatory-signaling-pathway-in-the-sciatic-nerve
#9
Chih-Yang Chung, Yi-Wei Chang, Chun-Jen Huang, Po-Kai Wang, Hung-Chieh Wan, Yi-Ying Lin, Ming-Chang Kao
Ischemia-reperfusion (IR) in the rat femoral artery has been proposed as an experimental model of vasculitic peripheral neuropathy (VPN) which presents neuropathic pain and peripheral nerve injury patterns observed clinically. This study investigates the involvement of the proinflammatory signaling pathway underlying the peripheral mechanisms of VPN. Male Sprague-Dawley rats were allocated to receive either a sham operation or IR. IR was induced by occluding the right femoral artery for 4h followed by reperfusion periods from 0 to 72h...
July 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28730074/protection-of-retinal-ganglion-cells-against-optic-nerve-injury-by-induction-of-ischemic-preconditioning
#10
Xia Liu, Jiu-Ping Liang, Ou Sha, Song-Juan Wang, Heng-Guo Li, Eric Y P Cho
AIM: To explore if ischemic preconditioning (IPC) can enhance the survival of retinal ganglion cells (RGCs) after optic nerve axotomy. METHODS: Twenty-four hours prior to retinal ischemia 60min or axotomy, IPC was applied for ten minutes in groups of (n=72) animals. The survival of RGCs, the cellular expression of heat shock protein 27 (HSP27) and heat shock protein 70 (HSP70) and the numbers of retinal microglia in the different groups were quantified at 7 and 14d post-injury...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729925/patterns-of-production-of-collagen-rich-deposits-in-peripheral-nerves-in-response-to-injury-a-pilot-study-in-a-rabbit-model
#11
Michael Rivlin, Andrew Miller, Jacob Tulipan, Pedro K Beredjiklian, Mark L Wang, Jolanta Fertala, Andrzej Steplewski, James Kostas, Andrzej Fertala
INTRODUCTION: Although collagen-rich deposits are the main component of neural scars, the patterns of their formation are ill defined. Essential to the biosynthesis of collagen fibrils are enzymes catalyzing posttranslational modifications and chaperones that control the formation of the collagen triple helix. Prolyl-4-hydroxylase (P4H) and heat shock protein-47 (HSP47) play a key role, and their production is upregulated during scar formation in human tissues. Alpha smooth muscle actin (αSMA) is also produced during fibrotic processes in myofibroblasts that participate in fibrotic response...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28727070/short-term-heat-stress-causes-altered-intracellular-signaling-in-oxidative-skeletal-muscle
#12
S Ganesan, C M Summers, S C Pearce, N K Gabler, R J Valentine, L H Baumgard, R P Rhoads, J T Selsby
Heat stress (HS) causes morbidities and mortalities, in part by inducing organ-specific injury and dysfunction. Further, HS markedly reduces farm animal productivity, and this is especially true for lean tissue accretion. The purpose of this investigation was to determine the extent to which short-term HS caused muscle dysfunction in skeletal muscle. We have previously found increased free radical injury in skeletal muscle following 24 h of HS. Thus, we hypothesized that HS would lead to apoptosis, autophagy, and decreased mitochondrial content in skeletal muscle...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28720296/urinary-heat-shock-protein-72-as-a-biomarker-of-acute-kidney-injury-in-dogs
#13
Yaron Bruchim, Yochai Avital, Michal Horowitz, Michal Mazaki-Tovi, Itamar Aroch, Gilad Segev
Early recognition of acute kidney injury (AKI) is important, as therapy is potentially more efficacious if instituted early in the course of disease. Urinary heat shock protein-72 to urinary creatinine ratio (uHSP72/uCr) was assessed as a diagnostic and prognostic marker in AKI in dogs. Fifty-three dogs were enrolled in five groups: healthy controls (n=11), urinary tract infection (n=10), chronic kidney disease (CKD; n=11), AKI (n=13), and acute decompensating CKD (n=8). Urinary heat shock protein-72 to urinary creatinine ratio was highest in the AKI group (P<0...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28715071/the-influence-of-ablation-power-reduction-associated-with-esophagus-location-on-pulmonary-veins-isolation-results-in-patients-with-paroxysmal-atrial-fibrillation-six-month-follow-up
#14
Piotr Buchta, Krzysztof Myrda, Michał Skrzypek, Adam Wojtaszczyk, Barbara Budzyn, Mariusz Gąsior
BACKGROUND: Catheter ablation of atrial fibrillation (AF) could be associated with a thermal esophageal (EO) injury. To avoid this complication intraluminal esophageal temperature monitoring and ablation power reduction at the areas with excessive heating could be used. However, the reduced energy could limit the ablation lesion depth, without creation of consist transmural scar and influence on long-term ablation results. AIM: The primary goal was to evaluate the homogeneity of forced ablation power reduction due to excessive EO heating in different parts of left atrium...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28709955/neonatal-injury-results-in-sex-dependent-nociceptive-hypersensitivity-and-social-behavioral-deficits-during-adolescence-without-altering-morphine-response
#15
Nikita N Burke, Tuan Trang
Neonatal injury is associated with persistent changes in sensory function and altered nociceptive thresholds that give rise to aberrant pain sensitivity in later life. While these changes are well documented in adult rodents, little is known about the consequences of neonatal injury during adolescence. Since adolescence is a critical developmental period during which persistent pain conditions can arise, we examined the impact of neonatal injury on nociception, social behavior and response to morphine in adolescent Sprague Dawley rats...
July 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28709048/intentional-burn-injury-assessment-of-allegations-of-self-infliction
#16
Juliet Cohen, Jo Pettitt, Emily Wilbourn
This study investigates the question of whether there is evidence that suggests the possibility of self-infliction, or self-infliction by proxy, of burn injury among a group of asylum claimants in the UK who have attributed such injuries to torture, and how such evidence might be assessed. The question arose from the observations of doctors at the UK-based charity Freedom from Torture that increasing numbers of individuals from Sri Lanka who described a history of torture had suffered severe and disfiguring burn injuries from heated metal objects, and the suggestion from asylum decision-makers that in some cases such injuries could have been acquired deliberately by self-infliction or self-infliction by proxy rather than by torture as claimed...
July 5, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28701862/protective-effect-of-ginsenosides-rk3-and-rh4-on-cisplatin-induced-acute-kidney-injury-in%C3%A2-vitro-and-in%C3%A2-vivo
#17
Seung-Hoon Baek, Byong-Kyu Shin, Nam Jae Kim, Sun-Young Chang, Jeong Hill Park
BACKGROUND: Nephrotoxicity is the major side effect in cisplatin chemotherapy. Previously, we reported that the ginsenosides Rk3 and Rh4 reduced cisplatin toxicity on porcine renal proximal epithelial tubular cells (LLC-PK1). Here, we aimed to evaluate the protective effect of ginsenosides Rk3 and Rh4 on kidney function and elucidate their antioxidant effect using in vitro and in vivo models of cisplatin-induced acute renal failure. METHODS: An enriched mixture of ginsenosides Rk3 and Rh4 (KG-KH; 49...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28699085/laser-interstitial-thermal-therapy-for-epilepsy
#18
REVIEW
Eric Prince, Shahin Hakimian, Andrew L Ko, Jeffrey G Ojemann, Michelle S Kim, John W Miller
MRI-guided laser interstitial thermal therapy (MgLiTT) uses a narrow diameter cannula to stereotactically target and heat deeper cerebral structures. This technique produces a precise lesion in the brain with great reliability because the localized tissue temperature change is monitored in real time. Because MgLiTT minimizes injury to surrounding brain, it appears to have a lower risk of affecting normal neurological function, and because it is done through a burr hole, there is less operative risk, less discomfort, and shorter hospitalizations...
September 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28698121/the-transcriptional-response-of-the-pacific-oyster-crassostrea-gigas-against-acute-heat-stress
#19
Chuanyan Yang, Qiang Gao, Chang Liu, Lingling Wang, Zhi Zhou, Changhao Gong, Anguo Zhang, Huan Zhang, Limei Qiu, Linsheng Song
The Pacific oyster, Crassostrea gigas, has evolved sophisticated mechanisms to adapt the changing ambient conditions, and protect themselves from stress-induced injuries. In the present study, the expression profiles of mRNA transcripts in the haemocytes of oysters under heat stress were examined to reveal the possible mechanism of heat stress response. There were 23,315, 23,904, 23,123 and 23,672 transcripts identified in the haemocytes of oysters cultured at 25 °C for 0, 6, 12, and 24 h (designed as B, H6, H12, H24), respectively...
July 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28694818/insights-into-the-molecular-events-that-regulate-heat-induced-chilling-tolerance-in-citrus-fruits
#20
María T Lafuente, Beatriz Establés-Ortíz, Luis González-Candelas
Low non-freezing temperature may cause chilling injury (CI), which is responsible for external quality deterioration in many chilling-sensitive horticultural crops. Exposure of chilling-sensitive citrus cultivars to non-lethal high-temperature conditioning may increase their chilling tolerance. Very little information is available about the molecular events involved in such tolerance. In this work, the molecular events associated with the low temperature tolerance induced by heating Fortune mandarin, which is very sensitive to chilling, for 3 days at 37°C prior to cold storage is presented...
2017: Frontiers in Plant Science
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