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https://www.readbyqxmd.com/read/28437509/thermal-perception-as-a-key-factor-for-assessing-effects-of-trigeminal-nerve-injury
#1
Hye-Kyoung Kim, Ki-Suk Kim, Mee-Eun Kim
AIMS: To conduct a functional examination using multimodal exploration of a sample of patients with iatrogenic trigeminal nerve injury to understand the underlying mechanisms of neuropathic pain following trigeminal nerve injury. METHODS: Subjective and objective symptoms and responses to thermal and electrical quantitative sensory testing (QST) were evaluated in 85 patients with unilateral trigeminal nerve injury. Objective symptoms were measured by seven clinical sensory tests...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28433042/-alarmins-and-surgical-injury
#2
J Máca, M Peteja
Surgical intervention is an inseparable part of the management of serious surgical disease. However, surgery also presents a potential risk related to the so-called surgical injury causing immune response. When dysregulated the immune activation is able to cause local complications (i.e. wound dehiscence, impaired healing). Systemic decompartmentization of the immunologic disturbance can negatively influence long-term outcomes (i.e. hospital length of stay, mortality). Due to aseptic conditions in the operating room, such an immune activation is almost always of sterile nature...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28428016/the-role-of-low-level-laser-therapy-on-neuropathic-pain-relief-and-interleukin-6-expression-following-spinal-cord-injury-an-experimental-study
#3
Negin Mojarad, Atousa Janzadeh, Mahmoud Yousefifard, Farinaz Nasirinezhad
INTRODUCTION: The effect of Low Level Laser Therapy (LLLT) as a non-invasive treatment of spinal cord injury (SCI) is still under investigation. Therefore, the present study aimed to evaluate the effectiveness of LLLT on neuropathic pain and interleukin-6 (IL-6) expression following SCI in male rats. METHODS: 46 adult male rats were divided into 5 groups of control, SCI, treatment with methylprednisolone sodium succinate (MPSS), 1-week LLLT and 2-week LLLT. Animals underwent behavioral evaluations for motor behavior, level of allodynia and hyperalgesia every week...
April 17, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28426518/pathophysiologic-insight-into-mesoamerican-nephropathy
#4
Magdalena Madero, Fernando E García-Arroyo, Laura-Gabriela Sánchez-Lozada
PURPOSE OF REVIEW: Mesoamerican nephropathy (MeN) is an emerging pathophysiological entity of Chronic kidney desease (CKD) not related to traditional risk factors (diabetes and hypertension) that have caused thousands of deaths in Central America, mainly in sugarcane workers. The focus of this review is to discuss the risk factors and probable mechanisms involved in the initiation and progression of this devastating disease. RECENT FINDINGS: Frequent episodes of subclinical Acute kidney injury caused by repetitive heat stress, dehydration, and strenuous work have been regarded as the main risk factors for MeN...
April 19, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28425051/upregulation-and-phosphorylation-of-hspb1-hsp25-and-hspb5-%C3%AE-b-crystallin-after-transient-middle-cerebral-artery-occlusion-in-rats
#5
Britta Bartelt-Kirbach, Alexander Slowik, Cordian Beyer, Nikola Golenhofen
Ischemic stroke leads to cellular dysfunction, cell death, and devastating clinical outcomes. The cells of the brain react to such a cellular stress by a stress response with an upregulation of heat shock proteins resulting in activation of endogenous neuroprotective capacities. Several members of the family of small heat shock proteins (HspBs) have been shown to be neuroprotective. However, yet no systematic study examined all HspBs during cerebral ischemia. Here, we performed a comprehensive comparative study comprising all HspBs in an animal model of stroke, i...
April 20, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28422872/effect-of-hsp27-and-cofilin-in-the-injury-of-hypoxia-reoxygenation-on-hepatocyte-membrane-f-actin-microfilaments
#6
Yafei Zhang, Jiazhong Wang, Hong Ji, Hongwei Lu, Le Lu, Jinlong Wang, Yiming Li
Hypoxia-reoxygenation (H/R) injury hepatocyte models were established to simulate the ischemia/reperfusion injury of transplanted organ. Through the study of the molecular mechanism of H/R on the F-actin damage of the liver cytomembrane, the mechanism of F-actin damage induced by ischemia and reperfusion was studied from the level of cell and molecule.The hypoxic environment of cells in vitro was simulated by chemical hypoxia agent CoCl2. Liver cells were detected by MTT, H/R group was subdivided into 3 subgroups: H/R 2, 4, and 6 h...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422768/mechanisms-involved-in-secondary-cardiac-dysfunction-in-animal-models-of-trauma-and-haemorrhagic-shock
#7
Nick M Wilson, Johanna Wall, Veena Naganathar, Karim Brohi, Henry D De'Ath
Clinical evidence reveals the existence of a trauma induced secondary cardiac injury (TISCI) which is associated with poor patient outcomes. The mechanisms leading to TISCI in injured patients are uncertain. Conversely, animal models of trauma haemorrhage have repeatedly demonstrated significant cardiac dysfunction following injury, and highlighted mechanisms through which this might occur. The aim of this review was to provide an overview of the animal studies describing TISCI and its pathophysiology.Basic science models of trauma show evidence of innate immune system activation via Toll-Iike receptors (TLRs), the exact protagonists of which remain unclear...
April 18, 2017: Shock
https://www.readbyqxmd.com/read/28422612/assessing-non-suicidal-self-injury-in-the-laboratory
#8
Brooke Ammerman, Mitchell E Berman, Michael S McCloskey
OBJECTIVES: The majority of non-suicidal self-injury (NSSI) research has used self- or clinician-rated measures of behavior which (a) are subject to reporting biases, or (b) have limited use in experimental designs which could illuminate causal relationships. Laboratory-based behavioral tasks have therefore been developed to assess NSSI-related behaviors more directly. METHODS: We reviewed the behavioral methods that have been developed to assess NSSI tendencies or behaviors over the past thirty-years...
April 19, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/28416582/relationship-between-oxygen-concentration-and-temperature-in-an-exothermic-warming-device
#9
Ben Brooks, Charles D Deakin
INTRODUCTION: Actively warming hypothermic patients or preventing hypothermia is critical in optimising outcomes in patients with traumatic injuries. Our aim was to investigate the effect of ambient oxygen concentration on the rate and change in temperature of the TechTrade Ready-Heat II exothermic (oxygen-activated) warming blanket, to evaluate safety and ascertain the risk of thermal injury. METHODS: A mannequin covered with an exothermic blanket was placed in a sealed oxygen tent...
April 17, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28415917/exercise-rehabilitation-immediately-following-ischemic-stroke-exacerbates-inflammatory-injury
#10
Fengwu Li, John T Pendy, Jessie N Ding, Changya Peng, Xiaorong Li, Jiamei Shen, Sainan Wang, Xiaokun Geng
OBJECTIVES: The rehabilitative benefits of physical exercise after stroke appear to be contingent upon exercise initiation timing. The present study assessed the hypothesis that very early post-stroke exercise would amplify cellular stress and increases expression of pro-inflammatory mediators, while exercise initiated later would limit the inflammation associated with cerebral ischemia/reperfusion injury. METHODS: Adult rats were subjected to middle cerebral artery occlusion and subsequently assigned to one of seven groups: one sham injury control group, three stroke groups subjected to exercise initiated after 6, 24 hours, or 3 days of reperfusion, and three stroke groups not subjected to exercise...
April 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28413526/neuroendoscopy-is-it-safe
#11
Manas Panigrahi, Bharat Gupta, Rajesh Reddy
BACKGROUND: The effect of heat in endoscopic instruments used for laparoscopy and hysteroscopy has been well-studied. Reports of thermal injury from nasal endoscopes have also been reported. However, there are no experimental studies, which have objectively documented and provided recommendations for safe use of endoscopes in neurosurgery. OBJECTIVES: To study the heat generated at the tip of the endoscope and the subsequent thermal damage caused to a cotton drape placed in proximity, by varying the intensity of light delivered through different optical cables, ambient (operating room) temperatures and working distances...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413481/oxymatrine-on-hsp90a-expression-and-apoptosis-in-a-model-of-lung-ischemia-reperfusion-injury
#12
Bing Zhu, Jianru Yang, Sifeng Chen, Pei Zhang, Lin Shen, Xiaolong Li, Jing Li
The protective effects of oxymatrine (OMT) on apoptosis and heat shock protein 90a (Hsp90a) expression in a rabbit model of lung ischemia-reperfusion injury (LIRI) were investigated. The model of LIRI was established in rabbits and they were randomly divided into two groups: The control group (group C, n=10), and experimental group (further divided into groups E1, n=10; and group E2, n=10), to measure the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) activity in lung tissue homogenates at several time points (T0, 0 min; T1, 60 min; T2, 120 min; T3, 180 min; and T4, 240 min), and to measures changes in lung tissue wet/dry weight ratio (W/D), apoptosis index (AI), and Hsp90a expression and organization at T2, T3 and T4...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412133/the-southwest-uk-burns-network-swuk-experience-of-electronic-cigarette-explosions-and-review-of-literature
#13
A Arnaout, H Khashaba, T Dobbs, F Dewi, S Pope-Jones, A Sack, C Estela, D Nguyen
INTRODUCTION: Since the introduction of e-cigarettes to the UK market in 2007 their popularity amongst young adults has significantly increased. These lithium-ion powered devices remain unregulated by the Standards Agency and as a result burns centres across the world have seen an increasing number of patients presenting with significant burns, resulting from poor quality batteries that appear to be liable to explode when over-heated, over-charged or incorrectly stored. METHODS: Retrospective and perspective review of all e-cigarette related burns presenting to the Southwest Burns Network; South Wales Burns Centre (Morriston Hospital) or to Bristol burns centre (Southmead Hospital) between Oct 15-July 16, followed by a review of available literature performed and eligible papers identified using PRISMA 2009 Checklist...
April 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28411725/effects-of-heat-stress-on-risk-perceptions-and-risk-taking
#14
Chu-Hsiang Chang, Thomas E Bernard, Jennifer Logan
Exposure to extreme heat at work is a serious occupational hazard, as exposure can result in heat-related illnesses, and it has been linked to increased risk of accidents and injuries. The current study aimed to examine whether heat exposure is related to changes in individuals' psychological process of risk evaluation, and whether acclimatization can mitigate the effect of heat exposure. A study with quasi-experiment research design was used to compare participants' risk perceptions and risk-taking behaviors at baseline, initial exposure to heat, and exposure after acclimatization across male participants who were exposed to heat (N = 6), and males (N = 5) and females (N = 6) who were in the control group who were exposed to ambient temperature...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28409327/heat-shock-proteins-and-kidney-disease-perspectives-of-hsp-therapy
#15
REVIEW
Natalia Chebotareva, Irina Bobkova, Evgeniy Shilov
Heat shock proteins (HSPs) mediate a diverse range of cellular functions, prominently including folding and regulatory processes of cellular repair. A major property of these remarkable proteins, dependent on intracellular or extracellular location, is their capacity for immunoregulation that optimizes immune activity while avoiding hyperactivated inflammation. In this review, recent investigations are described, which examine roles of HSPs in protection of kidney tissue from various traumatic influences and demonstrate their potential for clinical management of nephritic disease...
April 13, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28407135/pro-heat-stress-as-a-potential-etiology-of-mesoamerican-and-sri-lankan-nephropathy-a-late-night-consult-with-sherlock-holmes
#16
Richard J Johnson
Epidemics of chronic kidney disease are now recognized in Central America, Mexico, India and Sri Lanka, and there is also some evidence that similar epidemics may be occurring in the USA, Thailand and elsewhere. A common denominator for each location is manually working outside in extremely hot environments. Here we review the evidence that the primary etiology may be heat stress related to repeated subclinical or clinical acute kidney injury that eventually manifests as chronic kidney disease. In some aspects, the disease may manifest as subclinical heat stroke, subclinical rhabdomyolysis or a subclinical tumor lysis syndrome...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28400505/no-effect-of-ascorbate-on-cutaneous-vasodilation-and-sweating-in-older-men-and-those-with-type-2-diabetes-exercising-in-the-heat
#17
Naoto Fujii, Robert D Meade, Pegah Akbari, Jeffrey C Louie, Lacy M Alexander, Pierre Boulay, Ronald J Sigal, Glen P Kenny
Aging and chronic disease such as type 2 diabetes (T2D) are associated with impairments in the body's ability to dissipate heat. To reduce the risk of heat-related injuries in these heat vulnerable individuals, it is necessary to identify interventions that can attenuate this impairment. We evaluated the hypothesis that intradermal administration of ascorbate improves cutaneous vasodilation and sweating in older adults via nitric oxide synthase (NOS)-dependent mechanisms during exercise in the heat and whether these improvements, if any, are greater in individuals with T2D...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28398927/triggering-receptor-expressed-on-myeloid-cells-2-a-novel-regulator-of-immunocyte-phenotypes-confers-neuroprotection-by-relieving-neuroinflammation
#18
Qian Zhai, Feng Li, Xiyao Chen, Ji Jia, Sisi Sun, Dandan Zhou, Lei Ma, Tao Jiang, Fuhai Bai, Lize Xiong, Qiang Wang
BACKGROUND: Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear. METHODS: Mice were subjected to middle cerebral artery occlusion for 60 min. At 3 days after reperfusion, the effects of activation and suppression of triggering receptor expressed on myeloid cells 2 on immunocyte phenotypes (n = 5), neurobehavioral scores (n = 7), infarct volumes (n = 8), and neuronal apoptosis (n = 7) were analyzed...
April 10, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28396046/minocycline-prevents-muscular-pain-hypersensitivity-and-cutaneous-allodynia-produced-by-repeated-intramuscular-injections-of-hypertonic-saline-in-healthy-human-participants
#19
Mohamad Samir Samour, Saad Saulat Nagi, Peter John Shortland, David Anthony Mahns
Minocycline, a glial suppressor, prevents behavioural hypersensitivities in animal models of peripheral nerve injury. However clinical trials of minocycline in human studies have produced mixed results. This study addressed two questions: can repeated injections of hypertonic saline (HS) in humans induce persistent hypersensitivity? Can pre-treatment with minocycline, a tetracycline antibiotic with microglial inhibitory effects, prevent the onset of hypersensitivity? Twenty seven healthy participants took part in this double-blind, placebo-controlled study, consisting of six test sessions across 2 weeks...
April 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28395317/indoor-air-quality-in-photocopy-centers-nanoparticle-exposures-at-photocopy-workstations-and-the-need-for-exposure-controls
#20
John Martin, Philip Demokritou, Susan Woskie, Dhimiter Bello
Background: Photocopiers emit large amounts of nanoparticles (NP) and are a significant source of indoor air pollution. These emissions induce airway inflammation, irritation, and systemic oxidative stress in humans, lung injury and inflammation in animals, and cytotoxicity and epigenetic modifications in vitro. However, little is known regarding NP exposures at the workstation in the photocopy work environment, or the extent and use of emission controls. Objective: To survey the photocopy work environment with regards to emissions controls and to evaluate IAQ with emphasis on NP exposure at the operator's workstation...
January 1, 2017: Annals of Work Exposures and Health
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