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https://www.readbyqxmd.com/read/28081152/increased-serum-sodium-and-serum-osmolarity-are-independent-risk-factors-for-developing-chronic-kidney-disease-5-year-cohort-study
#1
Masanari Kuwabara, Ichiro Hisatome, Carlos A Roncal-Jimenez, Koichiro Niwa, Ana Andres-Hernando, Thomas Jensen, Petter Bjornstad, Tamara Milagres, Christina Cicerchi, Zhilin Song, Gabriela Garcia, Laura G Sánchez-Lozada, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson
BACKGROUND: Epidemics of chronic kidney disease (CKD) not due to diabetes mellitus (DM) or hypertension have been observed among individuals working in hot environments in several areas of the world. Experimental models have documented that recurrent heat stress and water restriction can lead to CKD, and the mechanism may be mediated by hyperosmolarity that activates pathways (vasopressin, aldose reductase-fructokinase) that induce renal injury. Here we tested the hypothesis that elevated serum sodium, which reflects serum osmolality, may be an independent risk factor for the development of CKD...
2017: PloS One
https://www.readbyqxmd.com/read/28079228/attenuated-recovery-of-contractile-function-in-aging-hearts-following-global-ischemia-reperfusion-role-of-extracellular-hsp27-and-tlr4
#2
Lihua Ao, Yufeng Zhai, Chunhua Jin, Joseph C Cleveland, David A Fullerton, Xianzhong Meng
BACKGROUND: While cardiac functional recovery is attenuated in the elderly following cardiac surgery with obligatory global myocardial ischemia/reperfusion (I/R), the underlying mechanism remains incompletely understood. We observed previously that human and mouse myocardium releases heat shock protein (HSP) 27 during global I/R. Extracellular HSP27 induces myocardial inflammatory response and plays a role in post-ischemic cardiac dysfunction in adult mouse hearts. OBJECTIVE: This study was to determine the role of extracellular HSP27 and Toll-like receptor 4 (TLR4) in the attenuated functional recovery in aging mouse hearts following global I/R...
December 19, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/28075022/the-mechanistic-basis-for-photobiomodulation-therapy-of-neuropathic-pain-by-near-infrared-laser-light
#3
Vanessa Milanesi Holanda, Maria Cristina Chavantes, Xingjia Wu, Juanita J Anders
BACKGROUND AND OBJECTIVE: Various irradiances have been reported to be beneficial for the treatment of neuropathic pain with near infrared light. However, the mechanistic basis for the beneficial outcomes may vary based on the level of irradiance or fluence rate used. Using in vivo and in vitro experimental models, this study determined the mechanistic basis of photobiomodulation therapy (PBMT) for the treatment of neuropathic pain using a high irradiance. STUDY DESIGN/MATERIALS AND METHODS: In vitro experiments: Cultured, rat DRG were randomly assigned to control or laser treatment (LT) groups with different irradiation times (2, 5, 30, 60, or 120 seconds)...
January 11, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28071899/near-ir-absorbing-gold-nanoframes-with-enhanced-physiological-stability-and-improved-biocompatibility-for-in-vivo-biomedical-applications
#4
Liying Wang, Yunching Chen, Hsin Yao Lin, Yung-Te Hou, Ling-Chu Yang, Aileen Y Sun, Jia-Yu Liu, Chien-Wen Chang, Dehui Wan
This paper describes the synthesis of near-infrared (NIR)-absorbing gold nanoframes (GNFs) and a systematic study comparing their physiological stability and biocompatibility with those of hollow Au-Ag nanoshells (GNSs), which have been used widely as photothermal agents in biomedical applications because of their localized surface plasmon resonance (LSPR) in the NIR region. The GNFs were synthesized in three steps: galvanic replacement, Au deposition, and Ag dealloying, using silver nanospheres (SNP) as the starting material...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28070684/a-pilot-cadaveric-study-of-temperature-and-adjacent-tissue-changes-after-exposure-of-magnetic-controlled-growing-rods-to-mri
#5
Selina Poon, Ryan Nixon, Stephen Wendolowski, Rachel Gecelter, Yen Hsun Chen, Jon-Paul DiMauro, Terry Amaral, Adam Graver, Daniel A Grande
PURPOSE: To test for possible thermal injury and tissue damage caused by magnetic-controlled growing rods (MCGRs) during MRI scans. METHODS: Three fresh frozen cadavers were utilized. Four MRI scans were performed: baseline, after spinal hardware implantation, and twice after MCGR implantation. Cross connectors were placed at the proximal end and at the distal end of the construct, making a complete circuit hinged at those two points. Three points were identified as potential sites for significant heating: adjacent to the proximal and distal cross connectors and adjacent to the actuators...
January 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28068166/risk-factors-for-injuries-during-military-static-line-airborne-operations-a-systematic-review-and-meta-analysis
#6
Joseph Knapik, Ryan Steelman
OBJECTIVE:  To identify and analyze articles in which the authors examined risk factors for soldiers during military static-line airborne operations. DATA SOURCES:  We searched for articles in PubMed, the Defense Technical Information Center, reference lists, and other sources using the key words airborne, parachuting, parachutes, paratrooper, injuries, wounds, trauma, and musculoskeletal. STUDY SELECTION:  The search identified 17 684 potential studies...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/28064415/alleviation-mechanisms-of-selenium-on-cadmium-spiked-neutrophil-injury-to-chicken
#7
Siran Tan, Qianru Chi, Tianqi Liu, Zhepeng Sun, Yahong Min, Ziwei Zhang, Shu Li
To determine the negative effects of cadmium (Cd) exposure and the protective role of selenium (Se) on Cd-spiked neutrophils of chicken, forty-eight 28-day-old Isa Brown male chickens were divided randomly into four groups. Group I (control group) was fed with the basic diet containing 0.2 mg/kg Se. Group II (Se-treated group) was fed with the basic diet supplemented with Na2SeO3, and the total Se content was 2 mg/kg. Group III (Se/Cd-treated group) was fed with the basic diet supplemented with Na2SeO3; the total Se content was 2 mg/kg and supplemented with 150 mg/kg CdCl2...
January 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28063242/effects-of-dietary-butyrate-supplementation-on-intestinal-integrity-of-heat-stressed-cockerels
#8
A M Abdelqader, M Abuajamieh, H M Hammad, A-R A Al-Fataftah
Butyrate modulates intestinal epithelial cell structure and function. Three hundred and sixty Lohmann LSL-Classic layer cockerels were used to investigate the effect of butyrate on heat stress-induced intestinal injury and intestinal integrity. The experiment was conducted from day 85 to 105 of age. The birds were divided randomly into three treatments: control, heat stress (HS), and heat stress provided with butyrate (HSB) at a level of 0.35 g/kg of diet. The control was reared at 21 ± 1 °C throughout the experiment...
January 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28058534/hyperbaric-oxygen-attenuates-neuropathic-pain-and-reverses-inflammatory-signaling-likely-via-the-kindlin-1-wnt-10a-signaling-pathway-in-the-chronic-pain-injury-model-in-rats
#9
Baisong Zhao, Yongying Pan, Haiping Xu, Xingrong Song
BACKGROUND: Hyperbaric oxygen (HBO) therapy is proven to attenuate neuropathic pain in rodents. The goal of the present study was to determine the potential involvement of the Kindlin-1/Wnt-10a signaling pathway during astrocyte activation and inflammation in a rodent model of neuropathic pain. METHODS: Rats were assigned into sham operation, chronic constriction injury (CCI), and CCI + HBO treatment groups. Neuropathic pain developed in rats following CCI of the sciatic nerve...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28052321/canonical-hedgehog-signaling-regulates-hepatic-stellate-cell-mediated-angiogenesis-in-liver-fibrosis
#10
Feng Zhang, Meng Hao, Huanhuan Jin, Zhen Yao, Naqi Lian, Li Wu, Jiangjuan Shao, Anping Chen, Shizhong Zheng
BACKGROUND AND PURPOSE: Hepatic stellate cells (HSCs) are liver-specific pericytes regulating angiogenesis during liver fibrosis. We aimed to elucidate the mechanisms by which hedgehog signaling regulated HSC angiogenic properties and to validate the therapeutic implications. EXPERIMENTAL APPROACH: Rats and mice were intoxicated with carbon tetrachloride for in vivo evaluation of hepatic angiogenesis and fibrotic injury. Diversified molecular approaches including real-time PCR, Western blot, luciferase reporter assay, chromatin immunoprecipitation, electrophoretic mobility shift assay, and co-immunoprecipitation were used to investigate the underlying mechanisms in vitro...
January 4, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28051192/global-warming-and-its-health-impact
#11
Antonella Rossati
Since the mid-19th century, human activities have increased greenhouse gases such as carbon dioxide, methane, and nitrous oxide in the Earth's atmosphere that resulted in increased average temperature. The effects of rising temperature include soil degradation, loss of productivity of agricultural land, desertification, loss of biodiversity, degradation of ecosystems, reduced fresh-water resources, acidification of the oceans, and the disruption and depletion of stratospheric ozone. All these have an impact on human health, causing non-communicable diseases such as injuries during natural disasters, malnutrition during famine, and increased mortality during heat waves due to complications in chronically ill patients...
January 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28043331/avermectin-induced-global-dna-hypomethylation-and-over-expression-of-heat-shock-proteins-in-cardiac-tissues-of-pigeon
#12
Ci Liu, Ye Cao, Shuo Zhou, Pervez Ahmed Khoso, Shu Li
Despite increasing evidences pointing to residues of avermectin (AVM) pose toxic effects on non-target organisms in environment, but the data in pigeon is insufficient. The alteration of global DNA methylation and response of heat shock proteins (Hsps) are important for assessing the AVM toxicity in cardiac tissues of pigeon (Columba livia). To investigate the effects of AVM exposure in cardiac tissues of pigeon, we detected the expression levels of DNA methyltransferases (Dnmts), methylated DNA-binding domain protein 2 (MBD2), and Hsp 60, 70 and 90...
January 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28040173/application-of-low-frequency-pulsed-ohmic-heating-for-inactivation-of-foodborne-pathogens-and-ms-2-phage-in-buffered-peptone-water-and-tomato-juice
#13
Sang-Soon Kim, Won Choi, Dong-Hyun Kang
The purpose of this study was to inactivate foodborne pathogens effectively by ohmic heating in buffered peptone water and tomato juice without causing electrode corrosion and quality degradation. Escherichia coli O157:H7, Salmonella Typhimurium, and Listeria monocytogenes were used as representative foodborne pathogens and MS-2 phage was used as a norovirus surrogate. Buffered peptone water and tomato juice inoculated with pathogens were treated with pulsed ohmic heating at different frequencies (0.06-1 kHz)...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28039200/work-related-musculoskeletal-disorders-among-construction-workers-in-the-united-states-from-1992-to-2014
#14
Xuanwen Wang, Xiuwen Sue Dong, Sang D Choi, John Dement
OBJECTIVES: Examine trends and patterns of work-related musculoskeletal disorders (WMSDs) among construction workers in the USA, with an emphasis on older workers. METHODS: WMSDs were identified from the 1992-2014 Survey of Occupational Injuries and Illnesses (SOII), and employment was estimated from the Current Population Survey (CPS). Risk of WMSDs was measured by number of WMSDs per 10 000 full-time equivalent workers and stratified by major demographic and employment subgroups...
December 30, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28032559/bradykinin-stimulates-protein-kinase-d-mediated-colonic-myofibroblast-migration-via-cyclooxygenase-2-and-heat-shock-protein-27
#15
Eric Chu, Shyla Saini, Tiegang Liu, James Yoo
BACKGROUND: Inflammatory bowel disease is characterized by episodic intestinal injury and repair. Myofibroblasts are gastrointestinal tract stromal cells that regulate the reparative process and are known targets of inflammatory mediators including bradykinin (BK). However, the mechanisms through which inflammation regulates myofibroblast-induced wound healing remain incompletely understood. Here, we demonstrate, for the first time, that BK stimulates myofibroblast migration through protein kinase D (PKD)-mediated activation of the cyclooxygenase-2 (COX-2) and heat shock protein 27 (Hsp27) pathways...
October 20, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28026745/wearable-vector-electrical-bioimpedance-system-to-assess-knee-joint-health
#16
Sinan Hersek, Hakan Toreyin, Caitlin N Teague, Mindy L Millard-Stafford, Hyeon-Ki Jeong, Miheer M Bavare, Paul Wolkoff, Michael N Sawka, Omer T Inan
: We designed and validated a portable electrical bioimpedance (EBI) system to quantify knee joint health. METHODS: Five separate experiments were performed to demonstrate the: (1) ability of the EBI system to assess knee injury and recovery; (2) inter-day variability of knee EBI measurements; (3) sensitivity of the system to small changes in interstitial fluid volume; (4) reducing the error of EBI measurements using acceleration signals; (5) use of the system with dry electrodes integrated to a wearable knee wrap...
December 22, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28025005/macroscopic-and-histologic-analysis-of-vessel-wall-reaction-after-mechanochemical-endovenous-ablation-using-the-clarivein-oc-device-in-an-animal-model
#17
D Boersma, S T W van Haelst, R R J P van Eekeren, A Vink, M M J P Reijnen, J P P M de Vries, G J de Borst
OBJECTIVE/BACKGROUND: Mechanochemical endovenous ablation (MOCA) has been developed as a tumescentless technique to ablate saphenous veins and to avoid heat induced complications and post-procedural pain. The mechanism of action of MOCA is poorly understood. The present experiments were conducted to determine the effect of MOCA on vein wall injury and sclerosis in an animal model. METHODS: A total of 36 lateral saphenous veins (LSVs) were treated in 18 goats according to the human protocol...
December 23, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28018176/activated-microglia-induce-bone-marrow-mesenchymal-stem-cells-to-produce-glial-cell-derived-neurotrophic-factor-and-protect-neurons-against-oxygen-glucose-deprivation-injury
#18
Bingke Lv, Feng Li, Jie Fang, Limin Xu, Chengmei Sun, Jianbang Han, Tian Hua, Zhongfei Zhang, Zhiming Feng, Qinghua Wang, Xiaodan Jiang
In this study, we investigated interactions among microglia (MG), bone marrow mesenchymal stem cells (BMSCs) and neurons in cerebral ischemia and the potential mechanisms using an in vitro oxygen-glucose deprivation (OGD) model. Rat BMSCs were incubated with conditioned medium (CM) from in vitro cultures of OGD-activated rat MG and murine BV2 MG cells. Effects of glial cell-derived neurotrophic factor (GDNF) on rat neuron viability, apoptosis, lactate dehydrogenase (LDH) leakage and mitochondrial membrane potential (MMP) were analyzed in this model...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28011300/thermal-inactivation-and-sublethal-injury-kinetics-of-salmonella-enterica-and-listeria-monocytogenes-in-broth-versus-agar-surface
#19
Xiang Wang, Frank Devlieghere, Annemie Geeraerd, Mieke Uyttendaele
The objective of the present study was to compare the thermal inactivation and sublethal injury kinetics of Salmonella enterica and Listeria monocytogenes in broth (suspended cells) and on solid surface (agar-seeded cells). A 3-strain cocktail of S. enterica or L. monocytogenes inoculated in broth or on agar was subjected to heating in a water bath at various set temperatures (55.0, 57.5 and 60.0°C for S. enterica and 60.0, 62.5 and 65°C for L. monocytogenes). The occurrence of sublethally injured cells was determined by comparing enumerations on nonselective (TSAYE) and selective (XLD or ALOA) media...
December 14, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28005797/skin-burn-related-to-coblation-assisted-turbinoplasty
#20
Sung Jae Heo, Jung-Soo Kim
Coblation-assisted turbinoplasty is an effective and safe method to manage nasal obstruction. The common complications of the procedure are pain, bleeding, and crust formation. Since coblation does not generate high heat, direct burn injuries by coblation have been rarely reported. Nevertheless, the authors experienced a skin burn injury in a patient, which is the first patient related to coblation-assisted turbinoplasty. Therefore, surgeons need to be careful and prepared for an inadvertent heat injury at the site that touches the coblation device...
November 2016: Journal of Craniofacial Surgery
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