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https://www.readbyqxmd.com/read/29220865/silver-nano-particles-ameliorate-learning-and-spatial-memory-of-male-wistar-rats-by-prevention-of-amyloid-fibril-induced-neurotoxicity
#1
H Ramshini, A-S Moghaddasi, L-S Aldaghi, N Mollania, A Ebrahim-Habibi
Alzheimer's disease (AD) is a chronic degenerative disease characterized by the presence of amyloid plaques and neurofibrillary tangles (NFTs), which results into memory and learning impairments. In the present study, we showed that the aggregates formed by a protein that has no link with Alzheimer's disease, namely the hen egg white lysozyme (HEWL), were cytotoxic and decreased spatial learning and memory in rats. The effect of Ag-nano particles (Ag-NPs) was investigated on disruption of amyloid aggregation and preservation of cognitive behavior of rats...
December 8, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29220828/prediction-of-radiation-esophagitis-in-non-small-cell-lung-cancer-using-clinical-factors-dosimetric-parameters-and-pretreatment-cytokine-levels
#2
Peter G Hawkins, Philip S Boonstra, Stephen T Hobson, James A Hayman, Randall K Ten Haken, Martha M Matuszak, Paul Stanton, Gregory P Kalemkerian, Theodore S Lawrence, Matthew J Schipper, Feng-Ming Spring Kong, Shruti Jolly
Radiation esophagitis (RE) is a common adverse event associated with radiotherapy for non-small cell lung cancer (NSCLC). While plasma cytokine levels have been correlated with other forms of radiation-induced toxicity, their association with RE has been less well studied. We analyzed data from 126 patients treated on 4 prospective clinical trials. Logistic regression models based on combinations of dosimetric factors [maximum dose to 2 cubic cm (D2cc) and generalized equivalent uniform dose (gEUD)], clinical variables, and pretreatment plasma levels of 30 cytokines were developed...
December 5, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29220821/predictive-capabilities-of-various-constitutive-models-for-arterial-tissue
#3
Florian Schroeder, Stanislav Polzer, Martin Slažanský, Vojtěch Man, Pavel Skácel
INTRODUCTION: Aim of this study is to validate some constitutive models by assessing their capabilities in describing and predicting uniaxial and biaxial behavior of porcine aortic tissue. METHODS: 14 samples from porcine aortas were used to perform 2 uniaxial and 5 biaxial tensile tests. Transversal strains were furthermore stored for uniaxial data. The experimental data were fitted by four constitutive models: Holzapfel-Gasser-Ogden model (HGO), model based on generalized structure tensor (GST), Four-Fiber-Family model (FFF) and Microfiber model...
November 22, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29220777/scenario-modelling-of-land-use-land-cover-changes-in-munessa-shashemene-landscape-of-the-ethiopian-highlands
#4
Mengistie Kindu, Thomas Schneider, Martin Döllerer, Demel Teketay, Thomas Knoke
Models under a set of scenarios are used to simulate and improve our understanding of land use/land cover (LULC) changes, which is central for sustainable management of a given natural resource. In this study, we simulated and examined the possible future LULC patterns and changes in Munessa-Shashemene landscape of the Ethiopian highlands covering four decades (2012-2050) using a spatially explicit GIS-based model. Both primary and secondary sources were utilized to identify relevant explanatory variables (drivers) and LULC datasets for the model...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220761/climate-change-potential-effects-on-the-hydrological-regime-of-freshwater-springs-in-the-italian-northern-apennines
#5
Federico Cervi, Francesca Petronici, Attilio Castellarin, Marco Marcaccio, Andrea Bertolini, Lisa Borgatti
In large areas of the Italian Northern Apennines, hundreds of low-yield springs provide water for drinking and industrial purposes, with short groundwater flow paths being formed within fractured sedimentary rock units. This hydrogeological setting results in spring water discharges that closely follow meteoric water recharge patterns, leading to low-flow periods concentrated in the summer/early autumn. Therefore, the springs' outflow can be very sensitive to a shortage in water recharge, as it was the case in 2003 and 2017, when a prolonged period of drought caused severe water management issues...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220743/the-cigarette-dependence-scale-and-heaviness-of-smoking-index-as-predictors-of-smoking-cessation-after-10weeks-of-nicotine-replacement-therapy-and-at-6-month-follow-up
#6
Laurie Zawertailo, Sabrina Voci, Peter Selby
INTRODUCTION: The reliability and validity of the Cigarette Dependence Scale (CDS) has been tested in online studies and compared with other tobacco dependence measures. Findings regarding its ability to predict smoking cessation have been mixed. We examined whether the CDS predicted cessation among a sample that received nicotine replacement therapy (NRT) at a community workshop and assessed the incremental predictive validity of the CDS-5 and CDS-12 over the 2-item Heaviness of Smoking Index (HSI)...
November 27, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29220740/validity-of-health-insurance-data-to-identify-people-with-epilepsy
#7
Merel Wassenaar, Johannes A Carpay, Josemir W Sander, Roland D Thijs
BACKGROUND: Large administrative databases may prove useful to assess epilepsy-related comorbidity and mortality. Despite their increased use, their validity as data source in epilepsy is yet under-ascertained. METHODS: Achmea is a large Dutch health insurance company covering about 25% of the population. We performed a retrospective cohort study using data from the Achmea Health Insurance Database (AHID) over the period 2006-2009. To assess the validity of epilepsy codes in the AHID, we randomly invited 1000 individuals (age 18-75 years insured by Achmea), attending an epilepsy centre or a district hospital during 2006-2009, to participate...
December 5, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29220738/increasing-value-and-reducing-waste-by-optimizing-the-development-of-complex-interventions-enriching-the-development-phase-of-the-medical-research-council-mrc-framework
#8
Nienke Bleijenberg, Janneke M de Man-van Ginkel, Jaap C A Trappenburg, Roelof G A Ettema, Carolien G Sino, Noor Heim, Thóra B Hafsteindóttir, David A Richards, Marieke J Schuurmans
BACKGROUND: In recent years there has been much emphasis on 'research waste' caused by poor question selection, insufficient attention to previous research results, and avoidable weakness in research design, conduct and analysis. Little attention has been paid to the effect of inadequate development of interventions before proceeding to a full clinical trial. OBJECTIVE: We therefore propose to enrich the development phase of the MRC Framework by adding crucial elements to improve the likelihood of success and enhance the fit with clinical practice METHODS: Based on existing intervention development guidance and synthesis, a comprehensive iterative intervention development approach is proposed...
December 5, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29220733/a-fast-method-for-ghb-gluc-quantitation-in-whole-blood-by-gc-ms-ms-tqd-for-forensic-purposes
#9
Ana S Dias, André L Castro, Paula Melo, Sónia Tarelho, Pedro Domingues, João Miguel Franco
γ-Hydroxybutyric acid (GHB) is an endogenous compound with a historical use, both in licit and illicit terms. Importantly, the post-mortem behavior of GHB has been studied due to the possibility of using this compound as a biomarker for estimating the post-mortem interval (PMI). However, the post-mortem behavior of the recently discovered glucuronated GHB metabolite (GHB-GLUC) has not been studied. Nevertheless, GHB-GLUC may also have potential both to assist in PMI determination and also to increase the window of detection of GHB consumption...
December 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29220728/assessment-of-long-term-exposure-to-airborne-dioxin-and-cadmium-concentrations-in-the-lyon-metropolitan-area-france
#10
T Coudon, H Hourani, C Nguyen, E Faure, F R Mancini, B Fervers, P Salizzoni
Identifying the long-term effects of airborne pollutants requires the computation of the spatial and temporal variability of their concentration in air to estimate the exposure of the population. To estimate exposure levels of individuals in a breast cancer case control study nested in a national prospective cohort, we determine here the differential impact of a variety of cadmium and dioxin sources on urban air over a large urban area and over a period of almost 20years. To that end, we couple an emission model, to estimate dioxin and cadmium atmospheric annual releases, with an urban dispersion model in order to compute pollutant concentration fields at a fine temporal (1h) and spatial (25m) resolution...
December 5, 2017: Environment International
https://www.readbyqxmd.com/read/29220716/self-accelerating-sulfur-reduction-via-polysulfide-to-realize-a-high-rate-sulfidogenic-reactor-for-wastewater-treatment
#11
Liang Zhang, Zefeng Zhang, Rongrong Sun, Shuang Liang, Guang-Hao Chen, Feng Jiang
Sulfur reduction is a promising alternative to sulfate reduction as it can generate sulfide at a low cost for the precipitation of heavy metals or autotrophic denitrification in wastewater treatment. However, the extremely low water solubility of elemental sulfur limits its bioavailability and results in a low sulfur-reduction rate. Polysulfide, which is naturally generated through reactions between sulfur and sulfide, can enhance the bioavailability of sulfur and thus contribute to high-rate sulfur reduction...
November 28, 2017: Water Research
https://www.readbyqxmd.com/read/29220710/life-satisfaction-and-its-associated-factors-among-money-boys-in-china
#12
A Zhang, J Yan, G Yang, X Tan, X Wang, S Tan
OBJECTIVES: Money Boy (MB) is a unique term used in China referring to a specialized population of men who sell sex to other men. Life satisfaction can influence one's health-related behaviors. The aim of our study was to find out the situation of MBs' life satisfaction and its associated factors. STUDY DESIGN: A cross-sectional study among MBs was conducted between July and December 2013 in Hunan province, China. METHODS: Respondent-driven sampling method was used for recruitment, with the initial seven 'seeds' found from a gay dating website, and 234 participants were enrolled into the study...
December 5, 2017: Public Health
https://www.readbyqxmd.com/read/29220618/psychological-comfort-of-paramedics-with-field-death-pronouncement-a-national-asian-study-to-prepare-paramedics-for-field-termination-of-resuscitation
#13
Desmond R H Mao, Marcus E H Ong, Chungli Bang, Mohamed D T Salim, Yih Yng Ng, Desiree A Lie
OBJECTIVES: Paramedics' decision to terminate field resuscitation without a physician present may depend on personal and external factors. This study investigates factors associated with paramedic psychological comfort with termination of resuscitation (TOR) to inform future training. METHODS: We administered an anonymous survey to all practicing paramedics in a large urban Asian Emergency Medical Services system where formal TOR training had not yet been conducted and field TOR was not routinely applied...
December 8, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29220573/the-mayonnaise-effect
#14
Klaas Wynne
Structuring caused by the mixing of liquids or the addition of solutes to a solvent causes the viscosity to increase. The classical example is mayonnaise: a mixture of two low viscosity liquids, water and oil, is structured through the addition of a surfactant creating a dispersed phase, causing the viscosity to increase a thousandfold. The dramatic increase in viscosity in highly concentrated solutions is a long-standing unsolved problem in physical chemistry. Here we will show that this viscosity increase can be understood in terms of the solute-induced structuring of the first solvation shell leading to a jamming transition at a critical concentration...
December 8, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29220554/assessment-of-dietary-sodium-intake-using-a-food-frequency-questionnaire-and-24-hour-urinary-sodium-excretion-a-systematic-literature-review
#15
Rachael M McLean, Victoria L Farmer, Alice Nettleton, Claire M Cameron, Nancy R Cook, Norman R C Campbell
Food frequency questionnaires (FFQs) are often used to assess dietary sodium intake, although 24-hour urinary excretion is the most accurate measure of intake. The authors conducted a systematic review to investigate whether FFQs are a reliable and valid way of measuring usual dietary sodium intake. Results from 18 studies are described in this review, including 16 validation studies. The methods of study design and analysis varied widely with respect to FFQ instrument, number of 24-hour urine collections collected per participant, methods used to assess completeness of urine collections, and statistical analysis...
December 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29220532/exploring-the-predictive-validity-of-the-susceptibility-to-smoking-construct-for-tobacco-cigarettes-alternative-tobacco-products-and-e-cigarettes
#16
Adam G Cole, Ryan David Kennedy, Ashok Chaurasia, Scott T Leatherdale
Introduction: Within tobacco prevention programming, it is useful to identify youth that are at risk for experimenting with various tobacco products and e-cigarettes. The susceptibility to smoking construct is a simple method to identify never-smoking students that are less committed to remaining smoke-free. However, the predictive validity of this construct has not been tested within the Canadian context or for the use of other tobacco products and e-cigarettes. Methods: This study used a large, longitudinal sample of secondary school students that reported never using tobacco cigarettes and non-current use of alternative tobacco products or e-cigarettes at baseline in Ontario, Canada...
December 6, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29220522/meta-analysis-of-genome-wide-association-studies-identifies-8-novel-loci-involved-in-shape-variation-of-human-head-hair
#17
Fan Liu, Yan Chen, Gu Zhu, Pirro G Hysi, Sijie Wu, Kaustubh Adhikari, Krystal Breslin, Ewelina Pospiech, Merel A Hamer, Fuduan Peng, Charanya Muralidharan, Victor Acuna-Alonzo, Samuel Canizales-Quinteros, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Francisco Rothhammer, Maria Catira Bortolini, Rolando Gonzalez-Jose, Changqing Zeng, Shuhua Xu, Li Jin, André G Uitterlinden, M Arfan Ikram, Cornelia M van Duijn, Tamar Nijsten, Susan Walsh, Wojciech Branicki, Sijia Wang, Andrés Ruiz-Linares, Timothy D Spector, Nicholas G Martin, Sarah E Medland, Manfred Kayser
Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28,964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21...
December 6, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29220506/a-molecular-portrait-of-de-novo-genes-in-yeasts
#18
Nikolaos N Vakirlis, Alex S Hebert, Dana A Opulente, Guillaume Achaz, Chris Todd Hittinger, Gilles Fischer, Joshua J Coon, Ingrid Lafontaine
New genes, with novel protein functions, can evolve "from scratch" out of intergenic sequences. These de novo genes can integrate the cell's genetic network and drive important phenotypic innovations. Therefore, identifying de novo genes and understanding how the transition from noncoding to coding occurs are key problems in evolutionary biology. However, identifying de novo genes is a difficult task, hampered by the presence of remote homologs, fast evolving sequences and erroneously annotated protein coding genes...
December 6, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29220450/ctd2-dashboard-a-searchable-web-interface-to-connect-validated-results-from-the-cancer-target-discovery-and-development-network
#19
Bülent Arman Aksoy, Vlado Dancík, Kenneth Smith, Jessica N Mazerik, Zhou Ji, Benjamin Gross, Olga Nikolova, Nadia Jaber, Andrea Califano, Stuart L Schreiber, Daniela S Gerhard, Leandro C Hermida, Subhashini Jagu, Chris Sander, Aris Floratos, Paul A Clemons
https://ctd2-dashboard.nci.nih.gov/.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29220393/process-service-quality-evaluation-based-on-dempster-shafer-theory-and-support-vector-machine
#20
Feng-Que Pei, Dong-Bo Li, Yi-Fei Tong, Fei He
Human involvement influences traditional service quality evaluations, which triggers an evaluation's low accuracy, poor reliability and less impressive predictability. This paper proposes a method by employing a support vector machine (SVM) and Dempster-Shafer evidence theory to evaluate the service quality of a production process by handling a high number of input features with a low sampling data set, which is called SVMs-DS. Features that can affect production quality are extracted by a large number of sensors...
2017: PloS One
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