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https://www.readbyqxmd.com/read/29054125/external-validation-of-a-cancer-risk-prediction-model-for-suspected-head-and-neck-cancer-referrals
#1
T Tikka, V Paleri, K MacKenzie
Head and neck cancer (HNC) affects more than 9000 new patients every year in England and Wales with an additional 1200 in Scotland. (1,2) Patients are urgently referred to head and neck clinics for further assessment when a suspicion of cancer is raised in the primary care setting. In England, the referral criteria are based on the NICE recommendations for symptoms associated with HNC. (2) A different combination of symptoms is described in the Scottish cancer referral guidelines. (3) There is currently no unified referral proforma across the different UK cancer networks...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054099/examining-factors-associated-with-elevated-lie-scale-responding-on-the-child-abuse-potential-inventory
#2
Amanda H Costello, Natalie J Shook, Nancy M Wallace, Cheryl B McNeil
Child maltreatment remains a serious public health issue in the United States. Therefore, it is important to engage in quality control of the assessment, prevention, and treatment services for families affected by maltreatment. Parenting capacity assessments (PCAs) are typically an integral part of service delivery for families affected by maltreatment and can carry serious consequences for the referred parent. The Child Abuse Potential Inventory (CAPI) is a measure that is widely used in PCAs; however, socially desirable responding on the CAPI can serve to invalidate the important information derived from this assessment, as well as lead to negative impressions of the parent...
October 17, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29054077/relationship-between-empathic-processing-and-drinking-behavior-in-project-match
#3
Charles S H Robinson, Kathryn Fokas, Katie Witkiewitz
INTRODUCTION: Family relationships, social connectedness and a greater network of supportive others each predict better drinking outcomes among individuals with alcohol use disorder (AUD). The association between social factors and drinking may be related to the ability of individuals to take the perspectives of others' mental and emotional states, defined as empathic processing (EP). As such, it may be the case that EP is associated with social support (SS) and drinking behavior among individuals with AUD, yet few prior studies have attempted to define EP in an AUD sample...
October 3, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29054076/genetic-polymorphisms-in-angiogenesis-related-genes-are-associated-with-worse-progression-free-survival-of-patients-with-advanced-gastrointestinal-stromal-tumours-treated-with-imatinib
#4
Michiel C Verboom, Jacqueline S L Kloth, Jesse J Swen, Tahar van der Straaten, Judith V M G Bovée, Stefan Sleijfer, Anna K L Reyners, Ron H J Mathijssen, Henk-Jan Guchelaar, Neeltje Steeghs, Hans Gelderblom
BACKGROUND: Imatinib 400 mg per day is first-line therapy for patients with gastrointestinal stromal tumours (GISTs). Although clinical benefit is high, progression-free survival (PFS) is variable. This study explores the relationship of single nucleotide polymorphisms (SNPs) in genes related to imatinib pharmacokinetics and pharmacodynamics and PFS in imatinib-treated patients with advanced GIST. METHODS: In 227 patients a pharmacogenetic pathway analysis was performed...
October 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29054068/quantitative-determination-of-additive-chlorantraniliprole-in-abamectin-preparation-investigation-of-bootstrapping-soft-shrinkage-approach-by-mid-infrared-spectroscopy
#5
Hong Yan, Xiangzhong Song, Kuangda Tian, Yilin Chen, Yanmei Xiong, Shungeng Min
A novel method, mid-infrared (MIR) spectroscopy, which enables the determination of Chlorantraniliprole in Abamectin within minutes, is proposed. We further evaluate the prediction ability of four wavelength selection methods, including bootstrapping soft shrinkage approach (BOSS), Monte Carlo uninformative variable elimination (MCUVE), genetic algorithm partial least squares (GA-PLS) and competitive adaptive reweighted sampling (CARS) respectively. The results showed that BOSS method obtained the lowest root mean squared error of cross validation (RMSECV) (0...
September 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29054011/one-pot-fabrication-of-n-doped-graphene-supported-dandelion-like-ptru-nanocrystals-as-efficient-and-robust-electrocatalysts-towards-formic-acid-oxidation
#6
Hui Xu, Bo Yan, Shumin Li, Jin Wang, Caiqin Wang, Jun Guo, Yukou Du
Engineering the architectures of metal nanocatalysts offers a valid approach for the development of electrocatalysts with greatly enhanced performances. Herein, we report the one-pot method to successfully fabricate the N-doped graphene (NG) supported dandelion-like PtRu nanocrystals. Such dandelion-like nanocrystals with different compositions can be readily tuned via the addition of different amounts of RuCl3. By virtue of the large accessible surface active areas, synergistic and electronic effect, as well as the successful introduction of NG, the as-obtained PtRu/NG with optimized compositions display outstandingly high electrocatalytic activity towards formic acid electrooxidation with the mass and specific activities of 1857...
October 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29053992/biomarker-guided-stratification-of-autoimmune-patients-for-biologic-therapy
#7
REVIEW
Sabine Ivison, Christine des Rosiers, Sylvie Lesage, John D Rioux, Megan K Levings
Autoimmunity results from an intersection of genetic and environmental factors that cause patient-specific perturbations in immune homeostasis. Defining autoimmunity-associated genetic factors has led to mechanistic insight into underlying etiologies, and the development of many biologic therapies that target the immune system. However, biomarker-informed pairing of patients with optimal biologic therapy is lacking. Here, we discuss platforms commonly used to find biomarkers that predict response to biologic therapy in autoimmunity and highlight recent biomarker discoveries...
October 17, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29053989/psychometric-properties-of-the-child-anxiety-life-interference-scale-preschool-version
#8
Tamsyn J Gilbertson, Amy J Morgan, Ronald M Rapee, Heidi J Lyneham, Jordana K Bayer
Despite growing recognition of childhood anxiety as a common and often debilitating clinical concern, we have limited knowledge of the particular ways in which anxiety interferes with daily life for young children who have not yet entered formal schooling. The present study evaluated the psychometric properties of the Child Anxiety Life Interference Scale - Preschool Version (CALIS-PV). The CALIS-PV is a brief (18 item) parent-report measure of the impacts of a young child's anxiety on their own life and that of her or his parent...
October 13, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29053987/the-role-of-executive-functions-and-psychiatric-symptom-severity-in-the-allen-cognitive-levels
#9
Sarah Schubmehl, Samuel H Barkin, Doug Cort
This study examined the relationship between Allen Cognitive Level (ACL) and psychiatric symptom severity, level of nursing support required to complete activities of daily living (ADLs), and post-hospitalization discharge disposition in a sample of 193 acute psychiatric inpatients. A subsample of 31 participants with acute psychotic disorders were administered three measures of executive functioning in order to examine the convergent validity between ACL and basic sequencing and shifting, phonemic fluency, and visuospatial construction...
October 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29053986/metacognitions-in-smoking-evidence-from-a-cross-cultural-validation-of-the-metacognitions-about-smoking-questionnaire-in-a-turkish-sample
#10
Leyla Alma, Marcantonio M Spada, Bruce A Fernie, Adviye Esin Yilmaz-Samanci, Gabriele Caselli, Ana V Nikčević
Metacognitions about the positive and negative effects of smoking have been associated with cigarette use and nicotine dependence. The aim of the present study was to validate the Turkish version of the Metacognitions about Smoking Questionnaire (MSQ; Nikčević et al., 2015). The sample consisted of 859 self-declared smokers (452 female) aged between 18 and 68 years (mean = 28.3; SD = 7.9). Once the English to Turkish translation of the MDQ was completed, confirmatory factor analyses were conducted based on the four-factor structure of the original measure...
October 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29053984/ecological-content-validation-of-the-information-assessment-method-for-parents-iam-parent-a-mixed-methods-study
#11
M Bujold, R El Sherif, P L Bush, J Johnson-Lafleur, G Doray, P Pluye
This mixed methods study content validated the Information Assessment Method for parents (IAM-parent) that allows users to systematically rate and comment on online parenting information. Quantitative data and results: 22,407 IAM ratings were collected; of the initial 32 items, descriptive statistics showed that 10 had low relevance. Qualitative data and results: IAM-based comments were collected, and 20 IAM users were interviewed (maximum variation sample); the qualitative data analysis assessed the representativeness of IAM items, and identified items with problematic wording...
October 4, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29053978/patterns-of-change-in-anxiety-and-depression-during-pregnancy-predict-preterm-birth
#12
Chelsea Doktorchik, Shahirose Premji, Donna Slater, Tyler Williamson, Suzanne Tough, Scott Patten
BACKGROUND: To determine whether changes in anxiety and depression during pregnancy influence the risk of having a preterm birth (PTB), and whether chronic stress modifies this relationship. METHODS: The data source for the current study is the All Our Babies prospective cohort (AOB). Anxiety and depression were measured at 17-24 weeks and again at 32-36 weeks' gestation using the Spielberg State Anxiety Scale and the Edinburgh Postnatal Depression Scale, respectively...
October 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053973/duration-of-moderate-to-vigorous-daily-activity-is-negatively-associated-with-slow-walking-speed-independently-from-step-counts-in-elderly-women-aged-75-years-or-over-a-cross-sectional-study
#13
Takuji Adachi, Yuji Kono, Kotaro Iwatsu, Yuko Shimizu, Sumio Yamada
OBJECTIVES: This study aimed 1) to examine whether objectively measured duration of moderate to vigorous physical activity (MVPA) was associated with slow walking speed, independent from step counts, in elderly women aged 75 or over (old-old) and 2) to determine a possible cut-off value for duration of MVPA related to slow walking speed. METHODS: Participants were 350 community-dwelling old-old women. Slow walking speed was defined as usual walking speed <1.0m/s...
October 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29053970/mtorc1-activator-slc38a9-is-required-to-efflux-essential-amino-acids-from-lysosomes-and-use-protein-as-a-nutrient
#14
Gregory A Wyant, Monther Abu-Remaileh, Rachel L Wolfson, Walter W Chen, Elizaveta Freinkman, Laura V Danai, Matthew G Vander Heiden, David M Sabatini
The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins...
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053962/identification-of-up-regulated-genes-from-the-metal-hyperaccumulator-aquatic-fern-salvinia-minima-baker-in-response-to-lead-exposure
#15
Daniel A Leal-Alvarado, A Martínez-Hernández, C L Calderón-Vázquez, D Uh-Ramos, G Fuentes, J H Ramírez-Prado, L Sáenz-Carbonell, J M Santamaría
Lead (Pb) is one of the most serious environmental pollutants. The aquatic fern Salvinia minima Baker is capable to hyper-accumulate Pb in their tissues. However, the molecular mechanisms involved in its Pb accumulation and tolerance capacity are not fully understood. In order to investigate the molecular mechanisms that are activated by S. minima in response to Pb, we constructed a suppression subtractive hybridization library (SSH) in response to an exposure to 40μM of Pb(NO3)2 for 12h. 365 lead-related differentially expressed sequences tags (ESTs) were isolated and sequenced...
October 16, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29053912/community-based-screening-of-hepatitis-c-with-a-one-step-rna-detection-algorithm-from-dried-blood-spots-analysis-of-key-populations-in-barcelona-spain
#16
V Saludes, C Folch, A Morales-Carmona, L Ferrer, L Fernández, R Muñoz, M Jiménez, E Loureiro, P Fernández-Dávila, E Bascuñana, J Casabona, E Martró
Alternative strategies are required to enhance the diagnosis of silent hepatitis C virus (HCV) infections in hard-to-reach key populations at risk. Among them, HCV prevalence and bio-behavioural data is scarce for HIV-negative men who have sex with men (MSM) and men and trans-women sex workers. We sought to describe and assess the potential benefits of a community-based one-step HCV screening and confirmatory strategy for these populations in Barcelona. The screening strategy based on a real-time RT-PCR assay for HCV-RNA detection in dried-blood spots (DBS) was validated and implemented in addition to an antibody point-of-care test in a community centre...
October 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29053894/french-translation-and-cross-cultural-adaptation-of-the-myotonic-dystrophy-health-index-mdhi
#17
Cynthia Gagnon, Marjolaine Tremblay, Isabelle Côté, Chad Heatwole
INTRODUCTION: Validation studies of disease-specific instruments for myotonic dystrophy type-1 (DM1) are required prior to their global use in clinical trials involving different cultures and countries. Here we translate and culturally adapt the Myotonic Dystrophy Health Index (MDHI), a disease-specific patient reported outcome measure, for a French DM1 population. METHOD: Using the ISPOR Task Force method for translation and adaptation of patient-reported outcome questionnaires, we created a French translation of the MDHI...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053889/optimization-of-mass-spectrometry-acquisition-parameters-for-determination-of-polycarbonate-additives-degradation-products-and-colorants-migrating-from-food-contact-materials-to-chocolate
#18
Chiara Bignardi, Antonella Cavazza, Carmen Laganà, Paola Salvadeo, Claudio Corradini
The interest towards the so-called "substances of emerging concerns", in particular referred to objects intended to come into contact with food is recently growing. Such substances can be found in traces in simulants and in food products put in contact with plastic materials. In this context, it is important to set up analytical systems characterized by high sensitivity, and to improve detection parameters to enhance signals. This work was aimed at optimizing a method based on UHPLC coupled to High Resolution Mass Spectrometry to quantify the most common plastic additives, and able to detect the presence of polymers degradation products and coloring agents migrating from plastic re-usable containers...
October 20, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29053837/preliminary-study-of-neutron-field-in-top-implart-proton-therapy-beam
#19
Paolo Ferrari, Monia Vadrucci, Alessandro Ampollini, Lorenzo Campani, Luigi Picardi, Concetta Ronsivalle, Francesca Mariotti
The TOP-IMPLART, a new proton therapy facility, is under development in Frascati ENEA Laboratories, near Rome. The project is centered on a medium-energy proton accelerator designed as a sequence of modular linear accelerators (the final energy will be 230 MeV). Being not a commercial product, measurements and simulation are fundamental to characterize the system and the radiation field, even during its construction. In this work some preliminary evaluations of the neutron contamination have been tried. The simulations were validated through some measurements obtaining a satisfactory agreement...
October 19, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29053833/clinical-pathological-and-functional-characterization-of-riboflavin-responsive-neuropathy
#20
Andreea Manole, Zane Jaunmuktane, Iain Hargreaves, Marthe H R Ludtmann, Vincenzo Salpietro, Oscar D Bello, Simon Pope, Amelie Pandraud, Alejandro Horga, Renata S Scalco, Abi Li, Balasubramaniem Ashokkumar, Charles M Lourenço, Simon Heales, Rita Horvath, Patrick F Chinnery, Camilo Toro, Andrew B Singleton, Thomas S Jacques, Andrey Y Abramov, Francesco Muntoni, Michael G Hanna, Mary M Reilly, Tamas Revesz, Dimitri M Kullmann, James E C Jepson, Henry Houlden
Brown-Vialetto-Van Laere syndrome represents a phenotypic spectrum of motor, sensory, and cranial nerve neuropathy, often with ataxia, optic atrophy and respiratory problems leading to ventilator-dependence. Loss-of-function mutations in two riboflavin transporter genes, SLC52A2 and SLC52A3, have recently been linked to Brown-Vialetto-Van Laere syndrome. However, the genetic frequency, neuropathology and downstream consequences of riboflavin transporter mutations are unclear. By screening a large cohort of 132 patients with early-onset severe sensory, motor and cranial nerve neuropathy we confirmed the strong genetic link between riboflavin transporter mutations and Brown-Vialetto-Van Laere syndrome, identifying 22 pathogenic mutations in SLC52A2 and SLC52A3, 14 of which were novel...
September 26, 2017: Brain: a Journal of Neurology
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