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https://www.readbyqxmd.com/read/29684943/the-diagnostic-implications-of-two-cases-of-known-rheumatoid-arthritis-from-the-cal-milano-cemetery-skeletal-collection
#1
Lucie Biehler-Gomez, Cristina Cattaneo
Rheumatoid arthritis (RA) is the most common erosive arthropathy and is of particular interest to forensic sciences. However, its diagnosis on bones remains challenging. We examined two skeletons from the CAL Milano Cemetery Skeletal Collection diagnosed with the pathology during life, to test the validity of the diagnostic criteria on bones. The first showed typical lesions of RA described in the literature. The second exhibited secondary osteoarthrosis, suggesting long-standing RA. A differential diagnosis including all four seronegative spondyloarthropathies, erosive osteoarthritis, gout and neuropathic arthropathy was also considered...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684937/the-swedish-school-attack-in-trollh%C3%A3-ttan
#2
Åsa Erlandsson, J Reid Meloy
This is a case report of the offender and offense characteristics of a targeted attack on a Swedish school using a sword, with a particular focus upon the offender's history, the relationship between mental disorder and ideology, and whether or not it was an act of terrorism. Findings indicate that the offender had no drug or psychiatric treatment history, but postoffense analysis suggests autism spectrum disorder, depression, and both suicidal ideation and intent. The offender planned and prepared for his attack, and the triggering event appeared to be the loss of a temporary job...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684918/correction-examining-the-construct-and-known-group-validity-of-a-composite-endpoint-for-the-older-persons-and-informal-caregivers-survey-minimum-data-set-topics-mds-a-large-scale-data-sharing-initiative
#3
Cynthia S Hofman, Jennifer E Lutomski, Han Boter, Bianca M Buurman, Anton J M de Craen, Rogier Donders, Marcel G M Olde Rikkert, Peter Makai, René J F Melis
[This corrects the article DOI: 10.1371/journal.pone.0173081.].
2018: PloS One
https://www.readbyqxmd.com/read/29684910/forensic-applications-of-supercritical-fluid-chromatography-mass-spectrometry
#4
REVIEW
Volodymyr Pauk, Karel Lemr
Achievements of supercritical fluid chromatography with mass spectrometric detection made in the field of forensic science during the last decade are reviewed. The main topics include analysis of traditional drugs of abuse (e.g. cannabis, methamphetamine) as well as new psychoactive substances (synthetic cannabinoids, cathinones and phenethylamines), doping agents (anabolic steroids, stimulants, diuretics, analgesics etc.) and chemical warfare agents. Control of food authenticity, detection of adulteration and identification of toxic substances in food are also pointed out...
April 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29684906/the-determination-of-pharmaceutically-active-thiols-using-hydrophilic-interaction-chromatography-followed-postcolumn-derivatization-with-o-phthaldialdehyde-and-fluorescence-detection
#5
Michal Douša
A rapid, precise and specific hydrophilic interaction chromatography (HILIC) combined with postcolumn derivatization using o-phthaldialdehyde and fluorescence detection was developed and validated for the determination of selected pharmaceutically active thiols. The analysis was carried out on a Diol HILIC column using a mobile phase consisting of acetonitrile and solution of 10 mmol/L citric acid adjusted with 1-propylamine to pH 5.5 in ratio 75:25 (v/v) for separation of cysteine and homocysteine and in ratio 85:15 (v/v) for separation of N-acetyl-l-cysteine and captopril...
April 16, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684884/multi-temporal-surveys-for-microplastic-particles-enabled-by-a-novel-and-fast-application-of-swir-imaging-spectroscopy-study-of-an-urban-watercourse-traversing-the-city-of-berlin-germany
#6
L Katharina Schmidt, Mathias Bochow, Hannes K Imhof, Sascha E Oswald
Following the widespread assumption that a majority of ubiquitous marine microplastic particles originate from land-based sources, recent studies identify rivers as important pathways for microplastic particles (MPP) to the oceans. Yet a detailed understanding of the underlying processes and dominant sources is difficult to obtain with the existing accurate but extremely time-consuming methods available for the identification of MPP. Thus in the presented study, a novel approach applying short-wave infrared imaging spectroscopy for the quick and semi-automated identification of MPP is applied in combination with a multitemporal survey concept...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684866/the-mediation-roles-of-discrepancy-stress-and-self-esteem-between-masculine-role-discrepancy-and-mental-health-problems
#7
Xue Yang, Joseph T F Lau, Zixin Wang, Yee-Ling Ma, Mason C M Lau
INTRODUCTION: Masculine role discrepancy and discrepancy stress occur when men perceive that they fail to live up to the ideal manhood derived from societal prescriptions. The present study examined the associations between masculine role discrepancy and two emotional and mental health problems (social anxiety and depressive symptoms), and potential mediation effects through discrepancy stress and self-esteem in a male general population. METHODS: Based on random population-based sampling, 2000 male residents in Hong Kong were interviewed...
April 16, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29684842/shear-force-analysis-by-core-location-in-longissimus-steaks-from-nellore-cattle-using-hyperspectral-images-a-feasibility-study
#8
Juliana Monteiro Balage, José Manuel Amigo, Daniel Silva Antonelo, Madeline Rezende Mazon, Saulo da Luz E Silva
Industry requires non-destructive real-time methods for quality control of meat in order to improve production efficiency and meet consumer expectations. Near Infrared Hyperspectral Images were used for tenderness evaluation of Nellore beef and the construction of tenderness distribution maps. To investigate whether the selection of the region of interest (ROI) in the image at the exact location where the shear force core was collected improves tenderness prediction and classification models, 50 samples from Longissimus muscle were imaged (1000-2500 nm) and shear force were measured (Warner-Bratzler)...
April 12, 2018: Meat Science
https://www.readbyqxmd.com/read/29684802/bayesian-estimates-of-the-incidence-of-rare-cancers-in-europe
#9
Laura Botta, Riccardo Capocaccia, Annalisa Trama, Christian Herrmann, Diego Salmerón, Roberta De Angelis, Sandra Mallone, Ettore Bidoli, Rafael Marcos-Gragera, Dorota Dudek-Godeau, Gemma Gatta, Ramon Cleries
BACKGROUND: The RARECAREnet project has updated the estimates of the burden of the 198 rare cancers in each European country. Suspecting that scant data could affect the reliability of statistical analysis, we employed a Bayesian approach to estimate the incidence of these cancers. METHODS: We analyzed about 2,000,000 rare cancers diagnosed in 2000-2007 provided by 83 population-based cancer registries from 27 European countries. We considered European incidence rates (IRs), calculated over all the data available in RARECAREnet, as a valid a priori to merge with country-specific observed data...
April 20, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29684795/screening-for-postpartum-anxiety-a-quality-improvement-project-to-promote-the-screening-of-women-suffering-in-silence
#10
Sarah Toler, Susan Stapleton, Kim Kertsburg, Tiffany J Callahan, Marie Hastings-Tolsma
BACKGROUND: Postpartum anxiety is a mental health problem that has largely been ignored by maternity care providers despite an estimated incidence as high as 28.9%. Though postpartum anxiety may or may not be accompanied by depression, and while screening for postpartum depression has become more common place, postpartum anxiety is often not assessed or addressed. PURPOSE: The purpose of this pilot quality improvement project was to implement a screening, treatment and referral program for postpartum anxiety in the birth centre environment...
April 3, 2018: Midwifery
https://www.readbyqxmd.com/read/29684744/the-role-of-circulating-tumour-cells-and-nucleic-acids-in-blood-for-the-detection-of-bladder-cancer-a-systematic-review
#11
REVIEW
Pramit Khetrapal, Matthew Wei Liang Lee, Wei Shen Tan, Liqin Dong, Patricia de Winter, Andrew Feber, John D Kelly
BACKGROUND: Blood-based biomarkers are a neglected resource in bladder cancer, where the mainstay of focus has been on urinary biomarkers. However, blood-based biomarkers are gaining popularity in other solid cancers, particularly circulating tumour cells (CTCs) and circulating nucleic acids. In this systematic review, we identify and discuss the diagnostic value of CTC, cell-free DNA and RNA based biomarkers in bladder cancer. METHODS: A MEDLINE/Pubmed systematic search was performed using the following keywords: (bladder cancer) AND (blood OR plasma OR serum) AND biomarker AND (DNA OR RNA OR cfDNA OR cell-free DNA OR RNA OR CTC)...
April 17, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29684739/evaluating-meteorological-data-from-weather-stations-and-from-satellites-and-global-models-for-a-multi-site-epidemiological-study
#12
Josh M Colston, Tahmeed Ahmed, Cloupas Mahopo, Gagandeep Kang, Margaret Kosek, Francisco de Sousa Junior, Prakash Sunder Shrestha, Erling Svensen, Ali Turab, Benjamin Zaitchik
BACKGROUND: Longitudinal and time series analyses are needed to characterize the associations between hydrometeorological parameters and health outcomes. Earth Observation (EO) climate data products derived from satellites and global model-based reanalysis have the potential to be used as surrogates in situations and locations where weather-station based observations are inadequate or incomplete. However, these products often lack direct evaluation at specific sites of epidemiological interest...
April 20, 2018: Environmental Research
https://www.readbyqxmd.com/read/29684705/dual-tail-arylsulfone-based-benzenesulfonamides-differently-match-the-hydrophobic-and-hydrophilic-halves-of-human-carbonic-anhydrases-active-sites-selective-inhibitors-for-the-tumor-associated-hca-ix-isoform
#13
Hany S Ibrahim, Heba Abdelrasheed Allam, Walaa R Mahmoud, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Eslam S Ibrahim, Hatem A Abdel-Aziz, Claudiu T Supuran
The synthesis and characterization of two new sets of arylsulfonehydrazone benzenesulfonamides (4a-4i with phenyl tail and 4j-4q with tolyl tail) are reported. The compounds were designed according to a dual-tails approach to modulate the interactions of the ligands portions at the outer rim of both hydrophobic and hydrophilic active site halves of human isoforms of carbonic anhydrase (CA, EC 4.2.1.1). The synthesized sulfonamides were evaluated in vitro for their inhibitory activity against the following human (h) isoforms, hCA I, II, IV and IX...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29684682/identification-and-validation-nucleolin-as-a-target-of-curcumol-in-nasopharyngeal-carcinoma-cells
#14
Juan Wang, Jiacai Wu, Xumei Li, Haowei Liu, Jianli Qin, Zhun Bai, Bixia Chi, Chen Xu
Identification of the specific protein target(s) of a drug is a critical step in unraveling its mechanisms of action (MOA) in many natural products. Curcumol, isolated from well known Chinese medicinal plant Curcuma zedoary, has been shown to possess multiple biological activities. It can inhibit nasopharyngeal carcinoma (NPC) proliferation and induce apoptosis, but its target protein(s) in NPC cells remains unclear. In this study, we employed a mass spectrometry-based chemical proteomics approach reveal the possible protein targets of curcumol in NPC cells...
April 20, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29684666/systematic-review-of-preservation-solutions-for-allografts-for-liver-transplantation-based-on-a-network-meta-analysis
#15
REVIEW
Fengying Rao, Jian Yang, Cheng Gong, Rong Huang, Qi Wang, Jun Shen
AIMS: The aim of this work was to determine the best preservation solutions for allografts for liver transplantation by quantitative network meta-analysis. METHODS: Global electronic databases including PubMed, EMBASE, and Cochrane Library were searched for relevant randomized controlled trials. Seven pieces of parametric data were extracted from included studies for pooled estimation. A consistency model was used for direct and indirect comparisons. The cumulative probability P value was utilized to rank the solutions...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684663/predictive-features-for-early-cancer-detection-in-barrett-s-esophagus-using-volumetric-laser-endomicroscopy
#16
Fons van der Sommen, Sander R Klomp, Anne-Fré Swager, Svitlana Zinger, Wouter L Curvers, Jacques J G H M Bergman, Erik J Schoon, Peter H N de With
The incidence of Barrett cancer is increasing rapidly and current screening protocols often miss the disease at an early, treatable stage. Volumetric Laser Endomicroscopy (VLE) is a promising new tool for finding this type of cancer early, capturing a full circumferential scan of Barrett's Esophagus (BE), up to 3-mm depth. However, the interpretation of these VLE scans can be complicated, due to the large amount of cross-sectional images and the subtle grayscale variations. Therefore, algorithms for automated analysis of VLE data can offer a valuable contribution to its overall interpretation...
April 13, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29684634/interactive-electronic-decision-trees-for-the-integrated-primary-care-management-of-febrile-children-in-low-resource-settings-review-of-existing-tools
#17
REVIEW
Kristina Keitel, Valérie D'Acremont
BACKGROUND: The lack of effective, integrated diagnostic tools pose a major challenge to the primary care management of febrile childhood illnesses. These limitations are especially evident in low-resource settings and are often inappropriately compensated by antimicrobial over-prescription. Interactive electronic decision trees (IEDTs) have the potential to close these gaps: guiding antibiotic use and better identifying serious disease. AIMS: This narrative review summarizes existing IEDTs, to provide an overview of their degree of validation, as well as to identify gaps in current knowledge and prospects for future innovation...
April 20, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29684623/decoration-of-rgd-mimetic-porous-scaffolds-with-engineered-and-devitalized-extracellular-matrix-for-adipose-tissue-regeneration
#18
Eleonora Rossi, Julien Guerrero, Paola Aprile, Alessandro Tocchio, Elisabeth A Kappos, Cristina Lenardi, Ivan Martin, Arnaud Scherberich
Fat grafting is emerging as a promising alternative to silicon implants in breast reconstruction surgery. Unfortunately, this approach does not provide a proper mechanical support and is affected by drawbacks such as tissue resorption and donor site morbidity. Synthetic scaffolds can offer a valuable alternative to address these challenges, but poorly recapitulate the biochemical stimuli needed for tissue regeneration. Here, we aim at combining the positive features of a structural, synthetic polymer to an engineered, devitalized extracellular matrix (ECM) to generate a hybrid construct that can provide a mix of structural and biological stimuli needed for adipose tissue regeneration...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684611/rna-seq-based-transcriptional-analysis-reveals-dynamic-genes-expression-profiles-and-immune-associated-regulation-under-heat-stress-in-apostichopus-japonicus
#19
Dongxue Xu, Shun Zhou, Lina Sun
In this study, we explored the gene expression profiles in Apostichopus japonicus under continuous heat stress (6 h, 48 h and 192 h) by applying RNA-seq technique. A total of 676, 1010 and 1083 differentially expressed genes were detected at three heat stress groups respectively, which suggested complex regulation of various biological processes. Then we focused on the changing of immune system under HS in sea cucumbers. Key immune-associated genes were involved in heat stress response, which were classified into six groups: heat shock proteins, transferrin superfamily members, effector genes, proteases, complement system, and pattern recognition receptors and signaling...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684593/renal-function-n-terminal-pro-b-type-natriuretic-peptide-propeptide-big-endothelin-and-patients-with-heart-failure-and-preserved-ejection-fraction
#20
Ingrid Gergei, Bernhard K Krämer, Hubert Scharnagl, Tatjana Stojakovic, Winfried März
Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure. In general practice, where echocardiography is not readily available, a biomarker for the diagnosis of a heart failure with preserved ejection fraction (HFpEF) would be useful. Since cardiac diseases frequently coincide with renal disease, there is a high need of valid risk stratification methods in patients affected with both. We therefore examined NT-proBNP and another biomarker, Big-Endothelin-1, as a marker of HFpEF in patients with CKD...
April 20, 2018: Peptides
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