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https://www.readbyqxmd.com/read/29909603/urinary-outcomes-in-patients-with-down-s-syndrome-and-hirschsprung-s-disease
#1
Alexander Johannes Martinus Dingemans, Carlos Albert Reck-Burneo, Molly Fuchs, Alejandra Vilanova Sanchez, Victoria Alison Lane, Erin Hoover, Tassiana Maloof, Laura Weaver, Marc A Levitt, Richard J Wood
INTRODUCTION:  Previous research in children with Hirschsprung's disease (HD) and Down's syndrome (DS) has focused on colorectal outcomes. We set out to review urinary outcomes in this patient group. METHODS:  The medical records of all patients aged five years and older with HD were reviewed, and patients and caregivers filled out the Vancouver Symptom Score at intake, which is designed and validated to diagnose dysfunctional elimination syndrome. RESULTS:  A total of 104 patients with HD were included in this study...
June 17, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29909584/comparison-of-clinical-results-between-novel-percutaneous-pedicle-screw-and-traditional-open-pedicle-screw-fixation-for-thoracolumbar-fractures-without-neurological-deficit
#2
Ming Yang, Qinpeng Zhao, Dingjun Hao, Zhen Chang, Shichang Liu, Xinhua Yin
OBJECTIVES: To compare the efficacy and safety of novel percutaneous minimally invasive pedicle screw fixation and traditional open surgery for thoracolumbar fractures without neurological deficit. METHODS: Sixty adult patients with single thoracolumbar fracture between June 2014 and June 2016 were recruited in this study, randomly divided into open fixation group (group A) or minimally invasive percutaneous fixation group (group B). Clinical and surgical evaluation including surgery time, blood losses, radiation times, hospital stay, and complication were performed...
June 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29909527/comparative-genome-wide-mapping-versus-extreme-pool-genotyping-and-development-of-diagnostic-snp-markers-linked-to-qtl-for-adult-plant-resistance-to-stripe-rust-in-common-wheat
#3
Jianhui Wu, Shuo Huang, Qingdong Zeng, Shengjie Liu, Qilin Wang, Jingmei Mu, Shizhou Yu, Dejun Han, Zhensheng Kang
A major stripe rust resistance QTL on chromosome 4BL was localized to a 4.5-Mb interval using comparative QTL mapping methods and validated in 276 wheat genotypes by haplotype analysis. CYMMIT-derived wheat line P10103 was previously identified to have adult plant resistance (APR) to stripe rust in the greenhouse and field. The conventional approach for QTL mapping in common wheat is laborious. Here, we performed QTL detection of APR using a combination of genome-wide scanning and extreme pool-genotyping. SNP-based genetic maps were constructed using the Wheat55 K SNP array to genotype a recombinant inbred line (RIL) population derived from the cross Mingxian 169 × P10103...
June 16, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29909492/modelling-glioma-invasion-using-3d-bioprinting-and-scaffold-free-3d-culture
#4
Derek M van Pel, Kaori Harada, Dandan Song, Christian C Naus, Wun Chey Sin
Glioma is a highly aggressive form of brain cancer, with some subtypes having 5-year survival rates of less than 5%. Tumour cell invasion into the surrounding parenchyma seems to be the primary driver of these poor outcomes, as most gliomas recur within 2 cm of the original surgically-resected tumour. Many current approaches to the development of anticancer therapy attempt to target genetic weaknesses in a particular cancer, but may not take into account the microenvironment experienced by a tumour and the patient-specific genetic differences in susceptibility to treatment...
June 16, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29909478/correction-to-reproducibility-and-validity-of-a-questionnaire-measuring-treatment-burden-on-patients-with-type-2-diabetes-diabetic-treatment-burden-questionnaire-dtbq
#5
Hitoshi Ishii, Koki Shin, Takahiro Tosaki, Tatsuya Haga, Yoshiki Nakajima, Toshihiko Shiraiwa, Nobuaki Watanabe, Miyuki Koizumi, Hiroki Nakajima, Sadanori Okada, Tsuyoshi Mashitani, Takako Mohri, Yasuhiro Akai
In the original publication, second author's name was incorrectly published as Hiroki Shin. The correct name should read as 'Koki Shin'.
June 16, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29909434/ionomer-and-protein-size-analysis-by-analytical-ultracentrifugation-and-electrospray-scanning-mobility-particle-sizer
#6
Simon E Wawra, Martin Thoma, Johannes Walter, Christian Lübbert, Thaseem Thajudeen, Cornelia Damm, Wolfgang Peukert
By combining analytical ultracentrifugation (AUC) in liquid phase and scanning mobility particle sizer (SMPS) in the gas phase, additional information on the particle size and morphology has been obtained for rigid particles. In this paper, we transfer this concept to soft particles, allowing us to analyze the size and molar mass of the short side chain perfluorosulfonic acid ionomer Aquivion® in a dilute aqueous suspension. The determination of the primary size and exact molar mass of this class of polymers is challenging since they are optically transparent and due to the formation of different aggregate structures depending on the concentration and solvent properties...
June 16, 2018: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29909421/application-of-isobaric-tags-for-relative-and-absolute-quantification-itraq-coupled-with-two-dimensional-liquid-chromatography-tandem-mass-spectrometry-in-quantitative-proteomic-analysis-for-discovery-of-serum-biomarkers-for-idiopathic-pulmonary-fibrosis
#7
Ying Zhang, Qian Xin, Zhen Wu, Chaochao Wang, Yongbin Wang, Qian Wu, Rui Niu
BACKGROUND The present study was performed to explore the presence of informative protein biomarkers of human serum proteome in idiopathic pulmonary fibrosis (IPF). MATERIAL AND METHODS Serum samples were profiled using iTRAQ coupled with two-dimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS) technique, and ELISA was used to validate candidate biomarkers. RESULTS A total of 394 proteins were identified and 97 proteins were associated with IPF. Four biomarker candidates generated from iTRAQ experiments - CRP, fibrinogen-α chain, haptoglobin, and kininogen-1 - were successfully verified using ELISA...
June 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29909413/validity-and-reliability-of-the-dutch-adaptation-of-the-actinic-keratosis-quality-of-life-questionnaire-akqol
#8
Kelly Vis, Rick Waalboer-Spuij, Dyon G C T M Snels, Loes M Hollestein
BACKGROUND: The Actinic Keratosis Quality of Life Questionnaire (AKQoL) is a disease-specific instrument to measure the impact of actinic keratosis (AK) on patients' lives. OBJECTIVE: To validate and test the psychometric properties of the AKQoL translated into the Dutch language (AKQoL-NL). METHODS: All new patients ≥50 years of age with untreated AK in a university medical center and a general hospital between August 2014 and August 2015 were eligible...
June 15, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29909410/what-is-the-role-of-soluble-urokinase-type-plasminogen-activator-in-renal-disease
#9
Moin A Saleem
Soluble urokinase-type plasminogen activator -(suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational modifications. Recently, [Hayek, et al: Nat Med 2017; 23: 945-953] it has been found that there is a link between suPAR and renal disease in several guises, and a key question is whether it is a driver or a marker of renal disease, and if so of which types of kidney damage. Subject of Review: Circulating suPAR has been postulated to cause acute proteinuric kidney disease, specifically focal segmental glomerulosclerosis (FSGS), though both the animal models and clinical data in the original reports have been challenged...
June 15, 2018: Nephron
https://www.readbyqxmd.com/read/29909405/long-story-short-an-introduction-to-the-short-term-and-long-term-six-sigma-quality-and-its-importance-in-the-laboratory-medicine-for-the-management-of-extra-analytical-processes
#10
Cristiano Ialongo, Sergio Bernardini
There is a compelling need for quality tools that enable effective control of the extra-analytical phase. In this regard, Six Sigma seems to offer a valid methodological and conceptual opportunity, and in recent times, the International Federation of Clinical Chemistry and Laboratory Medicine has adopted it for indicating the performance requirements for non-analytical laboratory processes. However, the Six Sigma implies a distinction between short-term and long-term quality that is based on the dynamics of the processes...
June 18, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29909401/prevalence-and-long-term-survival-after-coronary-artery-bypass-grafting-in-women-and-men-with-heart-failure-and-preserved-versus-reduced-ejection-fraction
#11
Louise Y Sun, Jack V Tu, Anan Bader Eddeen, Peter P Liu
BACKGROUND: Heart failure (HF) with reduced ejection fraction (rEF) is a widely regarded prognosticator after coronary artery bypass grafting. HF with preserved ejection fraction (pEF) accounts for up to half of all HF cases and is associated with considerable morbidity and mortality in hospitalized cohorts. However, HFpEF outcomes have not been elucidated in cardiac surgical patients. We investigated the prevalence and outcomes of HFpEF and HFrEF in women and men following coronary artery bypass grafting...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909374/the-command-trial-of-cognitive-therapy-for-harmful-compliance-with-command-hallucinations-ctch-a-qualitative-study-of-acceptability-and-tolerability-in-the-uk
#12
Max Birchwood, Laura Mohan, Alan Meaden, Nick Tarrier, Shon Lewis, Til Wykes, Linda M Davies, Graham Dunn, Emmanuelle Peters, Maria Michail
OBJECTIVES: To explore service user experiences of a 9-month cognitive behavioural therapy for command hallucinations in the context of a randomised controlled trial including their views on acceptability and tolerability of the intervention. DESIGN: Qualitative study using semistructured interviews. SETTING: The study took place across three sites: Birmingham, Manchester and London. Interviews were carried out at the sites where therapy took place which included service bases and participants' homes...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29909364/semiquantitative-analysis-using-standardized-uptake-value-in-123-i-fp-cit-spect-ct
#13
Akira Toriihara, Hiromitsu Daisaki, Akihiro Yamaguchi, Makoto Kobayashi, Shogo Furukawa, Katsuya Yoshida, Jun Isogai, Ukihide Tateishi
PURPOSE: To evaluate potential of a semiquantitative method using standardized uptake value (SUV) in 123 I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123 I-FP-CIT) single photon emission computed tomography/computed tomography (SPECT/CT) compared with specific binding ratio (SBR). MATERIALS AND METHODS: First, we performed a phantom study to validate the accuracy of measuring SUV. 52 patients (25 male, 27 female; mean age of 75.1-year-old; 40 and 12 patients with neurodegenerative diseases with or without presynaptic dopaminergic deficits, respectively) were enrolled in a retrospective study...
June 14, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29909354/screening-emergency-department-patients-for-opioid-drug-use-a-qualitative-systematic-review
#14
REVIEW
Preet Kaur Sahota, Siri Shastry, Dana B Mukamel, Linda Murphy, Narisu Yang, Shahram Lotfipour, Bharath Chakravarthy
INTRODUCTION: The opioid drug epidemic is a major public health concern and an economic burden in the United States. The purpose of this systematic review is to assess the reliability and validity of screening instruments used in emergency medicine settings to detect opioid use in patients and to assess psychometric data for each screening instrument. METHODS: PubMed/MEDLINE, PsycINFO, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, Cumulative Index to Nursing and Allied Health Literature and ClinicalTrials...
May 24, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29909335/selecting-sustainable-alternatives-for-cruise-ships-in-venice-using-multi-criteria-decision-analysis
#15
Marco Pesce, Stefano Terzi, Raid Issa Mahmoud Al-Jawasreh, Claudia Bommarito, Loris Calgaro, Stefano Fogarin, Elisabetta Russo, Antonio Marcomini, Igor Linkov
The rapid growth of cruise ship tourism increases the use of historic port cities as strategic hubs for cruise ship operators. Benefits derived from increased tourism for the municipality and cruise ships are often at odds with the environmental and social impacts associated with continued historical port use. This study illustrates the use of Multi-Criteria Decision Analysis (MCDA) for weighing of various criteria and metrics related to the environment, economy, and social sustainability for the selection of a sustainable cruise line route...
June 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29909319/simultaneous-determination-of-plasma-methotrexate-and-7-hydroxy-methotrexate-by-uhplc-ms-ms-in-patients-receiving-high-dose-methotrexate-therapy
#16
Shenghui Mei, Xiaoxu Shi, Yaming Du, Yong Cui, Chun Zeng, Xiaohui Ren, Kefu Yu, Zhigang Zhao, Song Lin
The plasma concentrations of methotrexate (MTX) and its major metabolite 7-hydroxy methotrexate (7-OH-MTX) are highly correlated with the toxicities in patients with high-dose MTX therapy. Routine monitoring of MTX and 7-OH-MTX plasma levels is useful for dose adjustment of rescue drugs and toxicity prevention. A UHPLC-MS/MS method for simultaneous determination of plasma MTX and 7-OH-MTX was developed, validated, and applied in 181 plasma samples. The ion transition was m/z 455.2 → 308.2 for MTX and m/z 471...
June 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29909302/affective-styles-in-mood-and-anxiety-disorders-clinical-validation-of-the-affective-style-questionnaire-asq
#17
Christina Totzeck, Tobias Teismann, Stefan G Hofmann, Ruth von Brachel, Xiao Chi Zhang, Verena Pflug, Jürgen Margraf
BACKGROUND: Emotion regulation plays a critical role in the development and maintenance of psychological disorders. Less is known about the association of affective styles and psychopathology. The 20-item "Affective Style Questionnaire" (ASQ) has been validated in nonclinical samples. The American and German validation studies resulted in a three-factor structure (concealing, adjusting, and tolerating). The present study aimed to investigate three aspects: (1) the validation of the ASQ within a clinical sample, (2) the examination of possible differences in affective styles between patients suffering from affective versus anxiety disorders, and (3) the association of affective styles and anxiety, depression, and stress symptoms...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909275/genetic-regulation-of-plasma-lipid-species-and-their-association-with-metabolic-phenotypes
#18
Pooja Jha, Molly T McDevitt, Emina Halilbasic, Evan G Williams, Pedro M Quiros, Karim Gariani, Maroun B Sleiman, Rahul Gupta, Arne Ulbrich, Adam Jochem, Joshua J Coon, Michael Trauner, David J Pagliarini, Johan Auwerx
The genetic regulation and physiological impact of most lipid species are unexplored. Here, we profiled 129 plasma lipid species across 49 strains of the BXD mouse genetic reference population fed either chow or a high-fat diet. By integrating these data with genomics and phenomics datasets, we elucidated genes by environment (diet) interactions that regulate systemic metabolism. We found quantitative trait loci (QTLs) for ∼94% of the lipids measured. Several QTLs harbored genes associated with blood lipid levels and abnormal lipid metabolism in human genome-wide association studies...
May 31, 2018: Cell Systems
https://www.readbyqxmd.com/read/29909270/feasibility-of-using-urinary-tdga-as-a-biomarker-for-vcm-exposures
#19
Chao W Chen, Dennis Hsieh, Fung-Chang Sung, Shan P Tsai
Thiodiglycolic acid (TDGA) is a major metabolite of vinyl chloride monomer (VCM), and it has been suggested as an exposure biomarker for VCM. The validity of this biomarker when the level of VCM is less than 5 ppm, however, is questionable. The objective of this article is to evaluate the feasibility of using urinary TDGA as a biomarker of VCM exposure in a community health risk assessment setting where the concentration of VCM in air is typically very low (likely below 1 ppm). To achieve this objective, we examine the fraction of urinary TDGA associated with different levels of VCM exposures of three studies from different countries, using estimations of the TDGA metabolite predicted by a PBPK model...
June 14, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29909226/investigation-of-sedimentation-rates-and-sediment-dynamics-in-danube-delta-lake-system-romania-by-210-pb-dating-method
#20
R-Cs Begy, H Simon, Sz Kelemen, L Preoteasa
Being a dynamic environment associated with complex costal, fluvial and marine processes, only a few studies regarding the evolution of the Danube Delta and the human impacts on its ecosystem have been carried out. Being a sensible to all processes occurring in its catchment area, information is stored in the deposited sediments, which can be used as tracers for natural and anthropogenic processes. The aim of this study is to determine a detailed reconstruction of the sedimentation rates in the last century by applying the 210 Pb dating method validated by 137 Cs profiles...
June 14, 2018: Journal of Environmental Radioactivity
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