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https://www.readbyqxmd.com/read/29245085/excretion-of-metabolites-of-the-synthetic-cannabinoid-jwh-018-in-urine-after-controlled-inhalation
#1
Stefan W Toennes, Anna Geraths, Werner Pogoda, Alexander Paulke, Cora Wunder, Eef L Theunissen, Johannes G Ramaekers
Each year, synthetic cannabinoids are occurring in high numbers on the illicit drug market but data obtained after controlled application are rare. The present study on pharmacokinetics in urine is part of a pilot study on adverse effects of JWH-018, which is one of the oldest and best known synthetic cannabinoids. Six subjects inhaled smoke from 2 and 3mg JWH-018. The drug and ten potential metabolites were analyzed in urine samples collected during 12h after inhalation by liquid chromatography-mass spectrometry (LC-MS/MS) without and with conjugate cleavage...
December 9, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29244776/internet-of-things-iot-based-design-of-a-secure-and-lightweight-body-area-network-ban-healthcare-system
#2
Yong-Yuan Deng, Chin-Ling Chen, Woei-Jiunn Tsaur, Yung-Wen Tang, Jung-Hsuan Chen
As sensor networks and cloud computation technologies have rapidly developed over recent years, many services and applications integrating these technologies into daily life have come together as an Internet of Things (IoT). At the same time, aging populations have increased the need for expanded and more efficient elderly care services. Fortunately, elderly people can now wear sensing devices which relay data to a personal wireless device, forming a body area network (BAN). These personal wireless devices collect and integrate patients' personal physiological data, and then transmit the data to the backend of the network for related diagnostics...
December 15, 2017: Sensors
https://www.readbyqxmd.com/read/29244188/-the-lights-of-the-electric-octopus-have-been-switched-off-visual-and-political-culture-in-edwardian-london
#3
James Thompson
This article reconstructs the visual culture of politics in Edwardian London through a study of the 1907 London County Council election. It moves beyond the memorable account given in Graham Wallas's Human Nature in Politics to examine the actors, especially associations and newspapers, that participated in the election. Drawing upon newspapers, election addresses, cartoon, leaflets, and posters, the article argues that Edwardian London was a prime site in the application of new media for political communication...
December 13, 2017: 20 Century British History
https://www.readbyqxmd.com/read/29244082/quantitation-of-cocaine-and-metabolites-phencyclidine-butalbital-and-phenobarbital-in-meconium-by-liquid-chromatography-tandem-mass-spectrometry
#4
Triniti L Scroggin, Gwendolyn A McMillin
In this study, a quantitative polarity switching liquid chromatography coupled with a tandem mass spectrometer (LC-MS/MS) method was developed to detect and quantify cocaine and metabolites (cocaethylene, benzoylecgonine and meta-hydroxybenzoylecgonine), phencyclidine (PCP) and barbiturates (phenobarbital and butalbital) in meconium. Accuracy and precision samples at 0.0125% and 75% of the upper limit of quantitation (ULOQ) were analyzed in triplicate over 5 days with accuracy above 84% and average %CV values below 11%...
December 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29244000/identification-of-recent-cases-of-hepatitis-c-virus-infection-using-physical-chemical-properties-of-hypervariable-region-1-and-a-radial-basis-function-neural-network-classifier
#5
James Lara, Mahder Teka, Yury Khudyakov
BACKGROUND: Identification of acute or recent hepatitis C virus (HCV) infections is important for detecting outbreaks and devising timely public health interventions for interruption of transmission. Epidemiological investigations and chemistry-based laboratory tests are 2 main approaches that are available for identification of acute HCV infection. However, owing to complexity, both approaches are not efficient. Here, we describe a new sequence alignment-free method to discriminate between recent (R) and chronic (C) HCV infection using next-generation sequencing (NGS) data derived from the HCV hypervariable region 1 (HVR1)...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29243821/improved-recovery-of-ancient-dna-from-subfossil-wood-application-to-the-world-s-oldest-late-glacial-pine-forest
#6
Bertalan Lendvay, Martin Hartmann, Sabine Brodbeck, Daniel Nievergelt, Frederick Reinig, Stefan Zoller, Laura Parducci, Felix Gugerli, Ulf Büntgen, Christoph Sperisen
Ancient DNA from historical and subfossil wood has a great potential to provide new insights into the history of tree populations. However, its extraction and analysis have not become routine, mainly because contamination of the wood with modern plant material can complicate the verification of genetic information. Here, we used sapwood tissue from 22 subfossil pines that were growing c. 13 000 yr bp in Zurich, Switzerland. We developed and evaluated protocols to eliminate surface contamination, and we tested ancient DNA authenticity based on plastid DNA metabarcoding and the assessment of post-mortem DNA damage...
December 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/29243441/-efficacy-and-safety-of-kuhuang-injection-in-treating-viral-hepatitis%C3%AF-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Jun Zhao, Xing Liao, Hui Zhao, Jing Yang, Wen Zou, Le Wang, Ying-Jie Zhi
To systematically evaluate the effectiveness and safety of Kuhuang injection in treating viral hepatitis. Eight electronic databases and clinic trials were searched to collect randomized controlled trials for the effect of Kuhuang injection in the treatment of viral hepatitis. According to the Cochrane Handbook 5.1, two independent reviewers screened out the literatures, extracted data and assessed the quality of thestudies included. RevMan5.3 software was used for the data analysis. A total of 32 articles were included, involving 3 188 patients, including male 1 951 cases (61...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29242780/an-expanded-phylogeny-for-the-genus-phytophthora
#8
Xiao Yang, Brett M Tyler, Chuanxue Hong
A comprehensive phylogeny representing 142 described and 43 provisionally named Phytophthora species is reported here for this rapidly expanding genus. This phylogeny features signature sequences of 114 ex-types and numerous authentic isolates that were designated as representative isolates by the originators of the respective species. Multiple new subclades were assigned in clades 2, 6, 7, and 9. A single species P. lilii was placed basal to clades 1 to 5, and 7. Phytophthora stricta was placed basal to other clade 8 species, P...
December 2017: IMA Fungus
https://www.readbyqxmd.com/read/29242490/an-authentic-record-of-i-eutropis-i-i-bibronii-i-gray-1838-reptilia-scincidae-from-sri-lanka
#9
Anslem DE Silva, W M J Sandaruwan, H K Sameera DE Zoysa, Kanishka D B Ukuwela
Among the eight species of Eutropis Fitzinger currently known from Sri Lanka, Eutropis bibronii (Gray, 1838) is among the least known. Hence, the occurrence of this species in Sri Lanka has been doubted by some authors since there were no confirmed records from live specimens for the past 70 years. The species has been previously reported mostly from northern regions of Sri Lanka. Here, we report the collection of a live Eutropis bibronii from the Chundikulam National Park in the Northern Province of Sri Lanka confirming its occurrence in the country...
October 3, 2017: Zootaxa
https://www.readbyqxmd.com/read/29241093/quantitative-analysis-of-drugs-in-hair-by-uhplc-high-resolution-mass-spectrometry
#10
Robert Kronstrand, Malin Forsman, Markus Roman
Liquid chromatographic methods coupled to high resolution mass spectrometry are increasingly used to identify compounds in various matrices including hair but there are few recommendations regarding the parameters and their criteria to identify a compound. In this study we present a method for the identification and quantification of a range of drugs and discuss the parameters used to identify a compound with high resolution mass spectrometry. Drugs were extracted from hair by incubation in a buffer:solvent mixture at 37°C during 18h...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29239271/how-can-we-keep-immigrant-travelers-healthy-health-challenges-experienced-by-canadian-south-asian-travelers-visiting-friends-and-relatives
#11
Rachel D Savage, Laura C Rosella, Natasha S Crowcroft, Jasleen Arneja, Eileen de Villa, Maureen Horn, Kamran Khan, Monali Varia
Immigrant travelers who visit friends and relatives (VFR travelers) experience substantially higher rates of travel-related infections than other travelers, in part due to low uptake of pretravel health advice. While barriers to accessing advice have been identified, better characterization is needed to inform targeted interventions. We sought to understand how South Asian VFR travelers perceived and responded to travel-related health risks by conducting group interviews with 32 adult travelers from an ethnoculturally diverse Canadian region...
December 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29238477/prevalence-of-metabolic-syndrome-in-iran-a-meta-analysis
#12
Rahim Ostovar, Faezeh Kiani, Fatemeh Sayehmiri, Masood Yasemi, Yazdan Mohsenzadeh, Yousof Mohsenzadeh
Background: Metabolic syndrome) MetS( is a complex risk factor which increases the risk of cardiovascular diseases and type 2 diabetes. There are many studies with various populations and results about the prevalence of MetS in Iran; in order to authenticate these studies and have an overall estimation of its prevalence in Iran, performing a meta-analysis seems to be necessary. Objective: This study aimed to investigate the prevalence of MetS and its components in Iran via meta-analysis method...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238448/a-systematic-review-of-research-studies-examining-telehealth-privacy-and-security-practices-used-by-healthcare-providers
#13
REVIEW
Valerie J M Watzlaf, Leming Zhou, Dilhari R Dealmeida, Linda M Hartman
The objective of this systematic review was to systematically review papers in the United States that examine current practices in privacy and security when telehealth technologies are used by healthcare providers. A literature search was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). PubMed, CINAHL and INSPEC from 2003 - 2016 were searched and returned 25,404 papers (after duplications were removed). Inclusion and exclusion criteria were strictly followed to examine title, abstract, and full text for 21 published papers which reported on privacy and security practices used by healthcare providers using telehealth...
2017: International Journal of Telerehabilitation
https://www.readbyqxmd.com/read/29238444/user-authentication-in-smartphones-for-telehealth
#14
Katherine A Smith, Leming Zhou, Valerie J M Watzlaf
Many functions previously conducted on desktop computers are now performed on smartphones. Smartphones provide convenience, portability, and connectivity. When smartphones are used in the conduct of telehealth, sensitive data is invariably accessed, rendering the devices in need of user authentication to ensure data protection. User authentication of smartphones can help mitigate potential Health Insurance Portability and Accountability Act (HIPAA) breaches and keep sensitive patient information protected, while also facilitating the convenience of smartphones within everyday life and healthcare...
2017: International Journal of Telerehabilitation
https://www.readbyqxmd.com/read/29237734/authentic-crac-channel-activity-requires-stim1-and-the-conserved-portion-of-the-orai-n-terminus
#15
Isabella Derler, Carmen Butorac, Adela Krizova, Michael Stadlbauer, Martin Muik, Marc Fahrner, Irene Frischauf, Christoph Romanin
Calcium (Ca2+) is an essential second messenger required for diverse signaling processes in immune cells. Ca2+ release-activated Ca2+ (CRAC) channels represent one main Ca2+ entry pathway into the cell. They are fully reconstituted via two proteins, the stromal interaction molecule 1 (STIM1), a Ca2+ sensor in the endoplasmic reticulum and the Ca2+ ion channel Orai in the plasma membrane. After Ca2+ store depletion, STIM1 and Orai couple to each other allowing Ca2+ influx. CRAC-/STIM1-mediated Orai channel currents display characteristic hallmarks such as high Ca2+ selectivity, an increase in current density when switching from a Ca2+-containing solution to a divalent-free Na+ one and fast Ca2+ dependent inactivation...
December 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29235972/decoding-dna-labels-by-melting-curve-analysis-using-real-time-pcr
#16
József A Balog, Liliána Z Fehér, László G Puskás
Synthetic DNA has been used as an authentication code for a diverse number of applications. However, existing decoding approaches are based on either DNA sequencing or the determination of DNA length variations. Here, we present a simple alternative protocol for labeling different objects using a small number of short DNA sequences that differ in their melting points. Code amplification and decoding can be done in two steps using quantitative PCR (qPCR). To obtain a DNA barcode with high complexity, we defined 8 template groups, each having 4 different DNA templates, yielding 158 (>2...
December 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29235919/fake-news-a-technological-approach-to-proving-the-origins-of-content-using-blockchains
#17
Steve Huckle, Martin White
In this article, we introduce a prototype of an innovative technology for proving the origins of captured digital media. In an era of fake news, when someone shows us a video or picture of some event, how can we trust its authenticity? It seems that the public no longer believe that traditional media is a reliable reference of fact, perhaps due, in part, to the onset of many diverse sources of conflicting information, via social media. Indeed, the issue of "fake" reached a crescendo during the 2016 U.S. Presidential Election, when the winner, Donald Trump, claimed that The New York Times was trying to discredit him by pushing disinformation...
December 2017: Big Data
https://www.readbyqxmd.com/read/29235038/simple-approach-for-de-novo-structural-identification-of-mannose-trisaccharides
#18
Hsu Chen Hsu, Chia Yen Liew, Shih-Pei Huang, Shang-Ting Tsai, Chi-Kung Ni
Oligosaccharides have diverse functions in biological systems. However, the structural determination of oligosaccharides remains difficult and has created a bottleneck in carbohydrate research. In this study, a new approach for the de novo structural determination of underivatized oligosaccharides is demonstrated. A low-energy collision-induced dissociation (CID) of sodium ion adducts was used to facilitate the cleavage of desired chemical bonds during the dissociation. The selection of fragments for the subsequent CID was guided using a procedure that we built from the understanding of the saccharide dissociation mechanism...
December 12, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29234879/calcium-phosphate-in-plant-trichomes-the-overlooked-biomineral
#19
Maximilian Weigend, Adeel Mustafa, Hans-Jürgen Ensikat
Calcium phosphate was unknown as a plant biomineral until recently reported in Neotropical Loasaceae. Here, we demonstrate its widespread occurrence in the trichomes of several plant families, including Brassicaceae. Calcium phosphate is the primary biomineral in, e.g., the bones and teeth of higher animals; in plants, it was only recently discovered in the stinging hairs and scabrid-glochidiate trichomes of South American Loasaceae (Ensikat et al. in Sci Rep UK 6:26073, 2016), where it appears to be deposited highly specifically, often replacing the common plant biomineral silica...
December 12, 2017: Planta
https://www.readbyqxmd.com/read/29233320/the-description-and-evaluation-of-virtual-worlds-in-clinical-pharmacy-education-in-northern-sweden
#20
Maria Gustafsson, Claire Englund, Gisselle Gallego
BACKGROUND AND PURPOSE: The purpose of this article is to describe and evaluate the use of a three-dimensional virtual world (3DVW) in a clinical pharmacy course. EDUCATIONAL ACTIVITY AND SETTING: Students are provided with training opportunities in simulated ward rounds and patient meetings in a 3DVW. The 3DVW enables students to practice communication with patients and colleagues in a professional manner. To evaluate the course and use of the 3DVW, an online course evaluation was completed by students after they had finished the clinical pharmacy course...
September 2017: Currents in Pharmacy Teaching & Learning
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