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https://www.readbyqxmd.com/read/29933506/pharmacodynamic-analysis-of-eribulin-safety-in-breast-cancer-patients-using-real-world-post-marketing-surveillance-data
#1
Takahisa Kawamura, Hidefumi Kasai, Valentina Fermanelli, Toshiaki Takahashi, Yukinori Sakata, Toshiyuki Matsuoka, Mika Ishii, Yusuke Tanigawara
Post-marketing surveillance is useful to collect safety data in real-world clinical settings. In this study, we firstly applied the post-marketing real-world data on a mechanistic model analysis for neutropenic profiles of eribulin in patients with recurrent or metastatic breast cancer (RBC/MBC). Demographic and safety data were collected using an active surveillance method from eribulin-treated RBC/MBC patients. Changes in neutrophil counts over time were analyzed using a mechanistic pharmacodynamic model...
June 22, 2018: Cancer Science
https://www.readbyqxmd.com/read/29930905/detection-of-blastocystis-in-clinical-stool-specimens-using-three-different-methods-and-morphological-examination-in-jones-medium
#2
Shashiraja Padukone, Jharna Mandal, Nonika Rajkumari, Ballambattu Vishnu Bhat, Rathinam Palamalai Swaminathan, Subhash Chandra Parija
Background: Blastocystis was identified almost a century ago, yet its biology and pathogenicity status in humans is obscure. Studies on Blastocystis in India are scanty and are mostly microscopy based. This study compared three detection modalities to determine their efficiency in the identification of Blastocystis in human feces. Materials and Methods: A total of 279 stool samples were screened using microscopy, culture (Jones' medium), and polymerase chain reaction (PCR)-based methods...
January 2018: Tropical Parasitology
https://www.readbyqxmd.com/read/29930525/growing-apart-a-longitudinal-assessment-of-the-relation-between-post-traumatic-growth-and-loneliness-among-combat-veterans
#3
Jacob Y Stein, Yafit Levin, Rahel Bachem, Zahava Solomon
The aftermath of war-related trauma may entail psychological devastation and is typically accompanied by various deleterious phenomena. These include, but are not limited to, high rates of loneliness. However, trauma may also result in positive outcomes such as personal, spiritual, and relational prosperity, which are typically considered under the conceptual framework of post-traumatic growth (PTG). PTG may theoretically contribute to either loneliness amelioration (e.g., via increasing one's appreciation of close relationships) or exacerbation (e...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29929567/how-does-barley-supplementation-in-lambs-grazing-alfalfa-affect-meat-sensory-quality-and-authentication
#4
T Devincenzi, A Prunier, K Meteau, S Prache
Excessive flavour in lamb meat is undesirable for consumers and can prompt purchase resistance. Volatile indoles responsible for off-flavours accumulate more in the fat of lambs on pasture than on grain and are enhanced when lambs graze alfalfa. Here, we investigated whether barley supplementation of lambs grazing alfalfa influences meat sensory quality. Using three groups of 12 male Romane lambs, we compared three feeding regimes: alfalfa grazing (AG), alfalfa grazing + daily supplementation with barley (29 g/kg live weight0...
June 22, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29927351/tor-complex-2-regulated-protein-kinase-ypk1-controls-sterol-distribution-by-inhibiting-starkin-domain-containing-proteins-located-at-plasma-membrane-endoplasmic-reticulum-contact-sites
#5
Françoise M Roelants, Neha Chauhan, Alexander Muir, Jameson C Davis, Anant K Menon, Timothy P Levine, Jeremy Thorner
In our proteome-wide screen (Muir et al. 2014 Elife), Ysp2 (also known as Lam2/Ltc4) was identified as a likely physiologically relevant target of TORC2-dependent protein kinase Ypk1 in the yeast Saccharomyces cerevisiae. Ysp2 was subsequently shown to be one of a new family of sterol-binding proteins located at plasma membrane (PM)-endoplasmic reticulum (ER) contact sites (Gatta et al. 2015 Elife). Here we document that Ysp2 and its paralog Lam4/Ltc3 are authentic Ypk1 substrates in vivo and show using genetic and biochemical criteria that Ypk1-mediated phosphorylation inhibits the ability of these proteins to promote retrograde transport of sterols from the PM to the ER...
June 21, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29927084/reagent-validation-to-facilitate-experimental-reproducibility
#6
Michael Williams
Many results reported in the biomedical research literature cannot be independently reproduced, undermining the basic foundations of science. This overview is intended for researchers who are committed to improving the quality and integrity of biomedical science by raising awareness of both the sources of irreproducibility, and activities specifically targeted to address the issue. The irreproducibility of biomedical research is due to a variety of factors, known and unknown, that markedly influence experimental outcomes...
May 16, 2018: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/29925045/authenticity-identification-and-classification-of-rhodiola-species-in-traditional-tibetan-medicine-based-on-fourier-transform-near-infrared-spectroscopy-and-chemometrics-analysis
#7
Tao Li, Chen Su
Rhodiola is an increasingly widely used traditional Tibetan medicine and traditional Chinese medicine in China. The composition profiles of bioactive compounds are somewhat jagged according to different species, which makes it crucial to identify authentic Rhodiola species accurately so as to ensure clinical application of Rhodiola. In this paper, a nondestructive, rapid, and efficient method in classification of Rhodiola was developed by Fourier transform near-infrared (FT-NIR) spectroscopy combined with chemometrics analysis...
June 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29925006/notch-signaling-facilitates-in-vitro-generation-of-cross-presenting-classical-dendritic-cells
#8
Margaret E Kirkling, Urszula Cytlak, Colleen M Lau, Kanako L Lewis, Anastasia Resteu, Alireza Khodadadi-Jamayran, Christian W Siebel, Hélène Salmon, Miriam Merad, Aristotelis Tsirigos, Matthew Collin, Venetia Bigley, Boris Reizis
The IRF8-dependent subset of classical dendritic cells (cDCs), termed cDC1, is important for cross-priming cytotoxic T cell responses against pathogens and tumors. Culture of hematopoietic progenitors with DC growth factor FLT3 ligand (FLT3L) yields very few cDC1s (in humans) or only immature "cDC1-like" cells (in the mouse). We report that OP9 stromal cells expressing the Notch ligand Delta-like 1 (OP9-DL1) optimize FLT3L-driven development of cDC1s from murine immortalized progenitors and primary bone marrow cells...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924810/residual-based-approach-for-authenticating-pattern-of-multi-style-diacritical-arabic-texts
#9
Saqib Hakak, Amirrudin Kamsin, Shivakumara Palaiahnakote, Omar Tayan, Mohd Yamani Idna Idris, Khir Zuhaili Abukhir
Arabic script is highly sensitive to changes in meaning with respect to the accurate arrangement of diacritics and other related symbols. The most sensitive Arabic text available online is the Digital Qur'an, the sacred book of Revelation in Islam that all Muslims including non-Arabs recite as part of their worship. Due to the different characteristics of the Arabic letters like diacritics (punctuation symbols), kashida (extended letters) and other symbols, it is written and available in different styles like Kufi, Naskh, Thuluth, Uthmani, etc...
2018: PloS One
https://www.readbyqxmd.com/read/29923277/cross-contamination-of-the-human-salivary-gland-hsg-cell-line-with-hela-cells-a-str-analysis-study
#10
Li-Chieh Lin, Osama Elkashty, Murali Ramamoorthi, Nathalie Trinh, Younan Liu, Gulshan Sunavala-Dossabhoy, Thomas Pranzatelli, Drew G Michael, Clara Chivasso, Jason Perret, John A Chiorini, Christine Delporte, Simon D Tran
The Human Salivary Gland cell line (HSG), labelled as a submandibular ductal cell line, is commonly used as in vitro models to study radiation therapy, Sjögren's syndrome, pleomorphic adenoma, mucocele, epithelial-to-mesenchymal transition, and epigenetics. However, the American Type Culture Collection (ATCC) has recently released a list of cross-contaminated cell lines that included HSG. Despite this notice, some research labs still use HSG as a salivary cell model. Accordingly, this study examined the authenticity of HSG sampled from three different laboratories METHODS: DNA was extracted from HSG and additional salivary cell lines (NS-SV-AC, NS-SV-DC, A253, HSY), and submitted for cell line authentication with short tandem repeat (STR) analysis RESULTS: All HSG samples had STR profiles indicating > 80% match with HeLa in both the ATCC and Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ) databases...
June 20, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29923201/gmrav1-regulates-regeneration-of-roots-and-adventitious-buds-by-the-cytokinin-signaling-pathway-in-arabidopsis-and-soybean
#11
Kexin Zhang, Lin Zhao, Xue Yang, Minmin Li, Jingzhe Sun, Kuo Wang, Yinghua Li, Yanhong Zheng, Yuheng Yao, Wenbin Li
The division and differentiation of cells are the basis of growth and development. Cytokinin plays an active role in cell growth division and differentiation. The Related to ABI3/VP1 (RAV) family comprises transcription factors in plants and all contain both AP2 and B3-like domains. In this study, GmRAV1 (Glycine max), which belongs to the AP2/ERF transcription factor family, was isolated and functionally characterized. Subcellular localization showed that GmRAV1 was localized to the nucleus and qRT-PCR analysis indicated that GmRAV1 was induced by cytokinin...
June 20, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29922486/identification-of-three-kinds-of-plumeria-flowers-by-dna-barcoding-and-hplc-specific-chromatogram
#12
Leilei Zhao, Xiaoxue Yu, Jie Shen, Xinjun Xu
DNA barcoding and HPLC specific chromatogram were used to identify three kinds of Plumeria flowers respectively. DNAs extracted from the three Plumeria species were amplified by PCR with universal primers, and the psb A- trn H region was selected. All the amplified products were sequenced and the results were analyzed by MEGA 5.0. Chemometric methods including principal components analysis and hierarchical clustering analysis were conducted on the SAS 9.0 software to demonstrate the variability among samples...
June 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29921294/trigger-factor-assisted-self-assembly-of-canine-parvovirus-vp2-protein-into-virus-like-particles-in-escherichia-coli-with-high-immunogenicity
#13
Liangliang Nan, Yunchao Liu, Pengchao Ji, Hua Feng, Chen Chen, Juan Wang, Dongmin Liu, Yinglei Cui, Yanwei Wang, Yafei Li, Enmin Zhou, Gaiping Zhang
Canine parvovirus (CPV) has been considered to be an important pathogen, which can cause acute infectious disease in canids. Although current vaccines are effective in preventing CPV infection, safety problems still remain unsolved. In this study, a subunit vaccine against CPV based on virus-like particles (VLPs) with good safety and immunogenicity is reported. Soluble CPV VP2 protein was produced by co-expression of chaperone trigger factor (Tf16) in Escherichia coli (E.coli), and assembled into CPV VLPs which could be affected by NaCl and pH...
June 19, 2018: Virology Journal
https://www.readbyqxmd.com/read/29920528/self-recovery-reversible-image-watermarking-algorithm
#14
Zhengwei Zhang, He Sun, Shangbing Gao, Shenghua Jin
The integrity of image content is essential, although most watermarking algorithms can achieve image authentication but not automatically repair damaged areas or restore the original image. In this paper, a self-recovery reversible image watermarking algorithm is proposed to recover the tampered areas effectively. First of all, the original image is divided into homogeneous blocks and non-homogeneous blocks through multi-scale decomposition, and the feature information of each block is calculated as the recovery watermark...
2018: PloS One
https://www.readbyqxmd.com/read/29920081/recent-developments-and-digital-perspectives-in-food-safety-and-authenticity
#15
Jan Fritsche
Food Safety is of fundamental importance for the food processing industry, food retailers and distributors, as well as for the competent authorities because of its potentially direct impact on consumers' health. Next to the prevention of microbiological, chemical, and physical hazards increasing efforts are currently made to combat risks associated with food fraud or food authenticity. Food Safety Management Systems nowadays comprise food safety, food defense, and food fraud prevention measures trying to cope with the increasing complexity and globalization of the food supply chains...
June 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29916730/dna-barcoding-reveals-cites-listed-species-among-taiwanese-government-seized-chelonian-specimens
#16
Chia-Hao Chang, Wei-Yu Dai, Ting-Yu Chen, An-Hsin Lee, Hsuan-Yi Hou, Shih-Hui Liu, Nian-Hong Jang-Liaw
Compared to traditional morphological identification, DNA barcoding-molecular identification based on sequencing of a segment of mitochondrial cytochrome c oxidase subunit I (COI)-provides a shortcut to authenticating chelonian identifications. Here, we selected 63 government-seized chelonian specimens deposited at Taipei Zoo for DNA barcoding analysis. DNA barcoding and subsequent phylogenetic analysis successfully authenticated 36 chelonian species, including five that are listed in CITES Appendix I. Approximately 90% (57/63) of the specimens were successfully authenticated by our molecular approach, but lack or error of BOLD reference sequences, biological processes such as hybridization, and uncertain species delimitation all reduced the accuracy of DNA barcoding...
June 19, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29916220/se33-locus-as-a-reliable-genetic-marker-for-forensic-dna-analysis-systems
#17
Munir Ahmad Bhinder, Muhammad Yasir Zahoor, Haleema Sadia, Muhammad Qasim, Rukhsana Perveen, Ghulam Murtaza Anjum, Muhammad Iqbal, Najeeb Ullah, Wasim Shehzad, Muhammad Tariq, Ali Muhammad Waryah
Background/aim: Genetic variation, an authentic tool of individual discrimination, is being used for forensic investigations worldwide. A missing result for even one out of 13-17 markers leads to an inconclusive report. Additional reliable markers are required to compensate such deficiencies. The SE33 locus has high genetic variability in different populations and is being used in forensic investigation systems in some countries. The purpose of the study was to assess the viability of use of the SE33 locus as a supportive marker for forensic DNA profiling...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29915998/cdaka-a-provably-secure-heterogeneous-cross-domain-authenticated-key-agreement-protocol-with-symptoms-matching-in-tmis
#18
Xiaoxue Liu, Wenping Ma
Telecare Medical Information System (TMIS) provides the flexible and convenient e-health care. It helps the patients to gain health monitoring information and provides patients to share their experience wirelessly. Traditional authentication and key agreement (AKA) protocols in TMIS are mostly considered in same-domain environment. However, future generation network may integrate various of wireless mesh networks under various domain. What's more, patients heterogeneous cross-domain service has become an inevitable trend...
June 18, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29915148/stable-isotope-dynamic-labeling-of-secretomes-sidls-identifies-authentic-secretory-proteins-released-by-cancer-and-stromal-cells
#19
Dean E Hammond, J Dinesh Kumar, Lorna Raymond, Deborah M Simpson, Robert J Beynon, Graham J Dockray, Andrea Varro
Analysis of secretomes critically underpins the capacity to understand the mechanisms determining interactions between cells and between cells and their environment. In the context of cancer cell micro-environments, the relevant interactions are recognised to be an important determinant of tumor progression. Global proteomic analyses of secretomes are often performed at a single time point and frequently identify both classical secreted proteins (possessing an N-terminal signal sequence), as well as many intracellular proteins, the release of which is of uncertain biological significance...
June 18, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29914335/-she-is-not-a-genuine-client-exploring-health-practitioner-s-mistrust-of-rape-survivors-in-nairobi-kenya
#20
Leso Munala, Emily Welle, Emily Hohenshell, Nene Okunna
Sexual violence is one of the most common forms of violence against women in Kenya. Recognizing this, the Kenyan government introduced health care sector guidelines for survivors of sexual violence. This study explores the care of rape survivors from the perspective of health-care practitioners and identifies a number of recommendations for improving the quality of care. Qualitative interviews were conducted with 28 health practitioners from eight post-rape care facilities located in Nairobi, Kenya. Data were analyzed using the Colaizzi's 1978 analytical model...
July 2018: International Quarterly of Community Health Education
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