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Keisuke Yoshihara, Minh Nhat Le, Koo Nagasawa, Hiroyuki Tsukagoshi, Hien Anh Nguyen, Michiko Toizumi, Hiroyuki Moriuchi, Masahiro Hashizume, Koya Ariyoshi, Duc Anh Dang, Hirokazu Kimura, Lay-Myint Yoshida
We performed molecular evolutionary analyses of the G gene C-terminal 3rd hypervariable region of RSV-A genotypes NA1 and ON1 strains from the paediatric acute respiratory infection patients in central Vietnam during the 2010-2012 study period. Time-scaled phylogenetic analyses were performed using Bayesian Markov Chain Monte Carlo (MCMC) method, and pairwise distances (p-distances) were calculated. Bayesian Skyline Plot (BSP) was constructed to analyze the time-trend relative genetic diversity of central Vietnam RSV-A strains...
October 13, 2016: Infection, Genetics and Evolution
Long-Wa Zhang, Ke Kang, Shi-Chang Jiang, Ya-Nan Zhang, Tian-Tian Wang, Jing Zhang, Long Sun, Yun-Qiu Yang, Chang-Chun Huang, Li-Ya Jiang, De-Gui Ding
Hyphantria cunea (Drury) (Lepidoptera: Arctiidae) is an invasive insect pest which, in China, causes unprecedented damage and economic losses due to its extreme fecundity and wide host range, including forest and shade trees, and even crops. Compared to the better known lepidopteran species which use Type-I pheromones, little is known at the molecular level about the olfactory mechanisms of host location and mate choice in H. cunea, a species using Type-II lepidopteran pheromones. In the present study, the H...
2016: PloS One
Ganna Kostygina, Hy Tran, Yaru Shi, Yoonsang Kim, Sherry Emery
OBJECTIVE: Despite recent increases in little cigar and cigarillo (LCC) use-particularly among urban youth, African-Americans and Latinos-research on targeted strategies for marketing these products is sparse. Little is known about the amount or content of LCC messages users see or share on social media, a popular communication medium among youth and communities of colour. METHODS: Keyword rules were used to collect tweets related to LCCs from the Twitter Firehose posted in October 2014 and March-April 2015...
October 2016: Tobacco Control
Kar-Hai Chu, Jon-Patrick Allem, Tess Boley Cruz, Jennifer B Unger
INTRODUCTION: This study documented images posted on Instagram of electronic cigarettes (e-cigarette) and vaping (activity associated with e-cigarette use). Although e-cigarettes have been studied on Twitter, few studies have focused on Instagram, despite having 500 million users. Instagram's emphasis on images warranted investigation of e-cigarettes, as past tobacco industry strategies demonstrated that images could be used to mislead in advertisements, or normalise tobacco-related behaviours...
September 22, 2016: Tobacco Control
Xiang Xiaohua, Wu Xinru, Chao Jiangtao, Yang Minglei, Yang Fan, Chen Guo, Liu Guanshan, Wang Yuanying
The coding products of WRKY gene family plays important roles in plant growth and development as well as in various stress responses. They have been identified in various plants, but only few in common tobacco (Nicotiana tabacum L.). In this study, 164 putative WRKY proteins in the common tobacco genome were identified by using the conserved WRKY sequence (PF03106) from the Pfam database. Phylogenetic trees, functional domain analysis, chromosomal localization, subcellular localization and tissue expression patterns were analyzed with the bioinformatics softwares, including DNAMAN 5...
September 20, 2016: Yi Chuan, Hereditas
Bachir Tazkarji, Robert Lam, Shawn Lee, Soumia Meiyappan
OBJECTIF: Guider les médecins de famille dans l'élaboration de plans de dépistage et de traitements préventifs à l'intention de leurs patients âgés. SOURCES DE L'INFORMATION: Une recension a été effectuée dans la base de données MEDLINE pour trouver des lignes directrices canadiennes sur les soins de santé primaires et les personnes âgées; des lignes directrices, des méta-analyses, des guides de pratique clinique ou des révisions systématiques portant sur le dépistage de masse chez les 80 ans et plus et les aînés fragiles, se limitant à ceux publiés entre 2006 et juillet 2016; et des articles sur les services de santé préventifs à l'intention des aînés et présentant un intérêt pour la pratique familiale ou les médecins de famille, limités à ceux publiés en anglais entre 2012 et juillet 2016...
September 2016: Canadian Family Physician Médecin de Famille Canadien
D Brent Weatherly, Duo Peng, Rick L Tarleton
BACKGROUND: The protozoan parasite Trypanosoma cruzi, causative agent of Chagas disease, depends upon a cell surface-expressed trans-sialidase (ts) to avoid activation of complement-mediated lysis and to enhance intracellular invasion. However these functions alone fail to account for the size of this gene family in T. cruzi, especially considering that most of these genes encode proteins lacking ts enzyme activity. Previous whole genome sequencing of the CL Brener clone of T. cruzi identified ~1400 ts variants, but left many partially assembled sequences unannotated...
2016: BMC Genomics
Mandana Behbahani, Hassan Mohabatkar, Mokhtar Nosrati
Lignin peroxidases (LiPs) are important enzymes in the degradation process of lignin which are presented in different species of fungi and bacteria. In the present study, sequence and structure-based properties of LPs in fungi and bacteria are compared. These properties include pseudo amino acid composition (PseAAC), physicochemical properties and the secondary structure. Autodock 4 has been used for docking between LiPs and lignan. The motifs of LiP were predicted by MEME tool. Statistical analysis and Multinomial Naïve Bayes (MNB) algorithm were used for the classification of two LiP protein groups...
September 8, 2016: Journal of Theoretical Biology
Meltem Okan, Esma Sari, Memed Duman
The main objective of this study is to develop molecularly imprinted polymer (MIP) based micromechanical cantilever sensor system that has high specificity, fast response time and is easily applicable by user for the detection of ciprofloxacin (CPX) molecule in water resources. Highly specific CPX imprinted nanoparticles were synthesized by miniemulsion polymerization technique. The average size of the synthesized nanoparticles was measured about 160nm with high monodispersivity. Covalent and monolayer binding of the MIP nanoparticles on cantilevers was provided by EDC/NHS activation...
August 16, 2016: Biosensors & Bioelectronics
Paul J Gruenewald, Meme Wang-Schweig, Christina Mair
OBJECTIVE: Many different measures of alcohol use are applied in survey-based epidemiological studies of alcohol-related risks. Differences in the selection of drinking measures and alternative specifications of quantitative relationships of these measures to problem outcomes limit researchers' abilities to compare and assess alcohol effects across studies. We used a quantitative definition of drinking patterns to identify relationships among drinking measures and uncover sources of bias in assessments of drinking risks...
September 2016: Journal of Studies on Alcohol and Drugs
Jui-Hung Hung, Zhiping Weng
This protocol describes a suite of tools for motif finding, using cis-regulatory motifs as an example. The first part of this protocol demonstrates the use of MEME (ab initio motif discovery), JASPAR (a motif database), Clover (searching for enriched known motifs), and MAST (scanning a sequence for motif sites) on a set of computationally predicted CREB-binding sequences downloaded from the UCSC Table Browser. The second part of the protocol shows how to use MEME-ChIP, an integrated suite of tools for analyzing ChIP-seq data, to discover motifs in STAT1 ChIP-seq peaks and compare them with known motifs in the JASPAR database...
August 29, 2016: Cold Spring Harbor Protocols
Andrew Whiten, David Erdal
UNLABELLED: We raise and discuss two issues for clarification. First, over what timescale is cultural group selection proposed to have been active? Unprecedented cooperation is inferred to have arisen in hunter-gather life well before the recent period on which Richerson et al. FOCUS: Second, what is the unit of selection? Groups (of human individuals)? Or cultural entities along the lines of "meme-complexes"?
January 2016: Behavioral and Brain Sciences
Carol Ellis-Barton
This article seeks to commence and encourage discussion around the upcoming ethical challenges of virality in network structures. When the call for participation in a research project on lupus in Ireland went from an advertisement in a newsletter to a meme (unit of transmissible information) on a closed Facebook page, the ethical considerations of virality were raised. The article analyzes the Association of Internet Researchers guidelines, Facebook policies, and the context of privacy in relation to virality...
July 2016: Journal of Empirical Research on Human Research Ethics: JERHRE
Zhijun Liao, Ying Ju, Quan Zou
G protein-coupled receptors (GPCRs) are the largest receptor superfamily. In this paper, we try to employ physical-chemical properties, which come from SVM-Prot, to represent GPCR. Random Forest was utilized as classifier for distinguishing them from other protein sequences. MEME suite was used to detect the most significant 10 conserved motifs of human GPCRs. In the testing datasets, the average accuracy was 91.61%, and the average AUC was 0.9282. MEME discovery analysis showed that many motifs aggregated in the seven hydrophobic helices transmembrane regions adapt to the characteristic of GPCRs...
2016: Scientifica
Susan R Harris
OBJECTIF: Décrire le test HINT (Harris Infant Neuromotor Test), un test d'évaluation du développement neuromoteur chez les nourrissons publié en 2010, qui s'appuie sur les normes canadiennes et peut être utilisé pour dépister les retards du développement moteur durant la première année de la vie. QUALITÉ DES DONNÉES: D'abondantes recherches ont été publiées sur la fiabilité intra-évaluateur, inter-évaluateur et test-retest ainsi que sur la validité convergente, prédictive, du contenu et des groupes connus du test HINT, de même que sur la sensibilité, la spécificité et les valeurs prédictives négatives et positives des inquiétudes des parents, telles qu'évaluées par le test HINT...
August 2016: Canadian Family Physician Médecin de Famille Canadien
Raazesh Sainudiin, David Welch
We derive a combinatorial stochastic process for the evolution of the transmission tree over the infected vertices of a host contact network in a susceptible-infected (SI) model of an epidemic. Models of transmission trees are crucial to understanding the evolution of pathogen populations. We provide an explicit description of the transmission process on the product state space of (rooted planar ranked labelled) binary transmission trees and labelled host contact networks with SI-tags as a discrete-state continuous-time Markov chain...
August 9, 2016: Journal of Theoretical Biology
Fred Y Peng, Zhiqiu Hu, Rong-Cai Yang
BACKGROUND: Many genes involved in responses to photoperiod and vernalization have been characterized or predicted in Arabidopsis (Arabidopsis thaliana), Brachypodium (Brachypodium distachyon), wheat (Triticum aestivum) and barley (Hordeum vulgare). However, little is known about the transcription regulation of these genes, especially in the large, complex genomes of wheat and barley. RESULTS: We identified 68, 60, 195 and 61 genes that are known or postulated to control pathways of photoperiod (PH), vernalization (VE) and pathway integration (PI) in Arabidopsis, Brachypodium, wheat and barley for predicting transcription factor binding sites (TFBSs) in the promoters of these genes using the FIMO motif search tool of the MEME Suite...
2016: BMC Genomics
Soheil Malekghasemi, Enver Kahveci, Memed Duman
A major application of microfluidic paper-based analytical devices (µPADs) includes the field of point-of-care (POC) diagnostics. It is important for POC diagnostics to possess properties such as ease-of-use and low cost. However, µPADs need multiple instruments and fabrication steps. In this study, two different chemicals (Hexamethyldisilazane and Tetra-ethylorthosilicate) were used, and three different methods (heating, plasma treatment, and microwave irradiation) were compared to develop µPADs. Additionally, an inkjet-printing technique was used for generating a hydrophilic channel and printing certain chemical agents on different regions of a modified filter paper...
October 1, 2016: Talanta
Marie-Claire Lévesque, Natalie Le Sage, Simon Berthelot, Valérie Boucher, Éric Mercier, Marcel Émond
UNLABELLED: Objectif Notre objectif primaire est de mesurer l'incidence d'HPI selon quatre définitions différentes retrouvées dans la littérature. Notre principal objectif secondaire est d'évaluer l'impact de la présence d'instabilité hémodynamique avant l'intubation sur l'incidence d'HPI. Le deuxième objectif secondaire consiste à déterminer l'incidence de l'HPI en fonction de l'intervalle de temps durant lequel la première hypotension survient. Méthode Une cohorte prospective a été constituée par les patients intubés en salle de réanimation à l'hôpital de l'Enfant-Jésus entre le 28/06/2011 et le 12/07/2012...
September 2016: CJEM
Nana Chikhladze, Elene Janberidze, Mariam Velijanashvili, Nikoloz Chkhartishvili, Memed Jintcharadze, Julia Verne, Dimitri Kordzaia
BACKGROUND: Physicians working in critical and intensive care settings encounter death of chronic incurable patients on a daily basis; however they have scant skills on how to communicate with the patients and their family members. The aim of the present survey is to examine communication of critical and intensive care physicians with patients' family members receiving treatment due to chronic incurable diseases/conditions and to compare the views of families with physicians working in critical and intensive care settings...
2016: BMC Palliative Care
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