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https://www.readbyqxmd.com/read/29018527/british-thoracic-society-quality-standards-for-home-oxygen-use-in-adults
#1
Jay Suntharalingam, Tom Wilkinson, Joseph Annandale, Claire Davey, Rhea Fielding, Daryl Freeman, Michael Gibbons, Maxine Hardinge, Sabrine Hippolyte, Vikki Knowles, Cassandra Lee, William MacNee, Jacqueline Pollington, Vandana Vora, Trefor Watts, Meme Wijesinghe
INTRODUCTION: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for home oxygen provision in the UK, together with measurable markers of good practice. Quality statements are based on the British Thoracic Society (BTS) Guideline for Home Oxygen Use in Adults. METHODS: Development of BTS Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28970488/single-cell-analysis-reveals-sexually-dimorphic-repertoires-of-interferon-%C3%AE-and-il-17a-producing-t-cells-in-salivary-glands-of-sj%C3%A3-gren-s-syndrome-mice
#2
Arun Wanchoo, Alexandria Voigt, Sukesh Sukumaran, Carol M Stewart, Indraneel Bhattacharya, Cuong Q Nguyen
The development of Sjögren's syndrome (SjS) is a dynamic and temporal process with a female predilection. Following the initial influx of immune cells, T cell clusters develop, accelerating the pathology in the salivary glands. Proinflammatory cytokines, IFN-γ and IL-17A, produced by T cells contribute synergistically to the disease. In this study, we examined the sexual dimorphism in cellular infiltrates of the salivary glands by using functional single-cell microengraving analysis. Using high-throughput sequencing, we investigated the clonal diversity of the T cell receptors (TCRs) of infiltrating IFN-γ and IL-17A-producing T cells in male and female SjS-susceptible (SjS(s)) C57BL/6...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851488/membrane-enclosed-multienzyme-meme-synthesis-of-2-7-anhydro-sialic-acid-derivatives
#3
Marie Monestier, Dimitrios Latousakis, Andrew Bell, Sandra Tribolo, Louise E Tailford, Ian J Colquhoun, Gwenaelle Le Gall, Hai Yu, Xi Chen, Martin Rejzek, Simone Dedola, Robert A Field, Nathalie Juge
Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases). A facile one-pot two-enzyme approach has been established for the synthesis of 2,7-anhydro-sialic acid derivatives including those containing different sialic acid forms such as Neu5Ac and N-glycolylneuraminic acid (Neu5Gc). The approach is based on the use of Ruminoccocus gnavus IT-sialidase for the release of 2,7-anhydro-sialic acid from glycoproteins, and the conversion of free sialic acid by a sialic acid aldolase...
August 19, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28827875/addiction-and-technology-plus-%C3%A3-a-change-plus-c-est-la-m%C3%A3%C2%AAme-the-more-things-change-the-more-they-remain-the-same
#4
Alok Sarin, Pratima Murthy, Sanjeev Jain
Excessive use of the internet for gambling, gaming and behavioural addiction, are a focus of contemporary interest. The authors delve into the archives to explore the connections between the growth of various forms of technology, commerce, addictive behaviours and responses of the State, in colonial India. The interplay between the growth of the telegraph network in 19th century India, and its influence on various forms of gambling, including speculation on opium prices, and the rain, as a theme of wager make interesting stories, as do the governmental responses to these...
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28816612/protecting-pregnant-workers-while-fighting-sexism-work-pregnancy-balance-and-pregnant-nurses-resistance-in-qu%C3%A3-bec-hospitalsprot%C3%A3-ger-les-travailleuses-enceintes-en-luttant-contre-le-sexisme-%C3%A3-quilibre-travail-grossesse-et-r%C3%A3-sistance-d-infirmi%C3%A3-res-enceintes
#5
Anne Renée Gravel, Jessica Riel, Karen Messing
Women's workplaces should guarantee healthy pregnancies while supporting pregnant women as workers. In Québec (Canada), a pregnant worker exposed to a "danger" for herself or her fetus may ask her employer to be reassigned to other work appropriate to her skills. This approach differs from other regulatory contexts in North America in that protection of fetal and maternal health is embedded in the health and safety legislation. The advantage is that the pregnant worker is guaranteed access to her full salary, but some may question whether specific provisions for pregnant women single out such women and produce risks for their careers or, conversely, pregnancy should receive even more special consideration...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28815224/a-picture-is-worth-a-thousand-words-electronic-cigarette-content-on-instagram-and-pinterest
#6
Alexander S Lee, Joy L Hart, Clara G Sears, Kandi L Walker, Allison Siu, Courteney Smith
INTRODUCTION: This study examined electronic cigarette (e-cig) content in visual materials posted on the social-media platforms Instagram and Pinterest. Both platforms allow users to upload pictures to the internet and share them globally. Users can search for pictures tagged with specific keywords and phrases. METHODS: Using content analysis, this study identified themes in image postings of e-cigs on social media. During five weeks of data collection, keywords were used to identify pictures related to e-cigs...
July 2017: Tobacco Prevention & Cessation
https://www.readbyqxmd.com/read/28796461/ce-que-peut-la-sociologie
#7
Bernard Lahire
When it is relational, processual, and it articulates the incorporated dispositions of the actors and the contexts of their actions, sociology "desevidentialize," denaturalize, desubstantialize, and historicize the social world by contributing to do away with spontaneous representations that distort the reality of things. Besides, when sociology studies the social at the level of the individuals and individual actions, it destroys the fictions (juridical and philosophical) of the isolated individuals, enclosed on himself, free and fully conscious of everything...
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28761016/the-evolution-of-religious-belief-in-humans-a-brief-review-with-a-focus-on-cognition
#8
Dhairyya Singh, Garga Chatterjee
Religion has been a widely present feature of human beings. This review explores developments in the evolutionary cognitive psychology of religion and provides critical evaluation of the different theoretical positions. Generally scholars have either believed religion is adaptive, a by-product of adaptive psychological features or maladaptive and varying amounts of empirical evidence supports each position. The adaptive position has generated the costly signalling theory of religious ritual and the group selection theory...
July 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28733902/clustering-and-candidate-motif-detection-in-exosomal-mirnas-by-application-of-machine-learning-algorithms
#9
Pallavi Gaur, Anoop Chaturvedi
BACKGROUND: The clustering pattern and motifs give immense information about any biological data. An application of machine learning algorithms for clustering and candidate motif detection in miRNAs derived from exosomes is depicted in this paper. Recent progress in the field of exosome research and more particularly regarding exosomal miRNAs has led much bioinformatic-based research to come into existence. The information on clustering pattern and candidate motifs in miRNAs of exosomal origin would help in analyzing existing, as well as newly discovered miRNAs within exosomes...
July 22, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28724993/prediction-of-presynaptic-and-postsynaptic-neurotoxins-by-combining-various-chou-s-pseudo-components
#10
Haiyan Huo, Tao Li, Shiyuan Wang, Yingli Lv, Yongchun Zuo, Lei Yang
Presynaptic and postsynaptic neurotoxins are two groups of neurotoxins. Identification of presynaptic and postsynaptic neurotoxins is an important work for numerous newly found toxins. It is both costly and time consuming to determine these two neurotoxins by experimental methods. As a complement, using computational methods for predicting presynaptic and postsynaptic neurotoxins could provide some useful information in a timely manner. In this study, we described four algorithms for predicting presynaptic and postsynaptic neurotoxins from sequence driven features by using Increment of Diversity (ID), Multinomial Naive Bayes Classifier (MNBC), Random Forest (RF), and K-nearest Neighbours Classifier (IBK)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710057/images-of-little-cigars-and-cigarillos-on-instagram-identified-by-the-hashtag-swisher-thematic-analysis
#11
Jon-Patrick Allem, Patricia Escobedo, Kar-Hai Chu, Tess Boley Cruz, Jennifer B Unger
BACKGROUND: Little cigar and cigarillo use is becoming more prevalent in the United States and elsewhere, with implications for public health. As little cigar and cigarillo use grows in popularity, big social media data (eg, Instagram, Google Web Search, Twitter) can be used to capture and document the context in which individuals use, and are marketed, these tobacco products. Big social media data may allow people to organically demonstrate how and why they use little cigars and cigarillos, unprimed by a researcher, without instrument bias and at low costs...
July 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28685556/use-of-supercharged-cover-screw-as-static-magnetic-field-generator-for-bone-healing-2nd-part-in-vivo-enhancement-of-bone-regeneration-in-rabbits
#12
F Bambini, A Santarelli, A Putignano, M Procaccini, G Orsini, D Di Iorio, L Memè, D Sartini, M Emanuelli, L Lo Muzio
In 1979, Pulsed electromagnetic fields (PEMFs) were approved by the Food and Drug Administration as an effective method in the treatment of non-unions. As well as PEMFs, also static magnetic fields (SMFs) have been widely investigated in orthopaedic studies. Even if the exact mechanism of action is not well understood, a large number of studies showed specific effects both at cellular and tissue levels. As bone fracture healing and osseointegration share the same biological events, the application of magnetic field stimulation in order to facilitate the osseointegration process has been suggested...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28671251/identification-and-characterization-of-the-bzip-transcription-factor-involved-in-zinc-homeostasis-in-cereals
#13
A R Henriques, D da R Farias, A Costa de Oliveira
Members of the basic leucine zipper family, as bZIP19, are considered to be essential regulators of the adaptation to zinc deficiency. Knowing that this gene as well as its targets are conserved in the plant kingdom, we followed an in silico approach to identify and characterize the bzip19 gene in cereals. Through BLASTp in Phytozome database, 33 bzip19 genes were identified on the genomes of Oryza sativa, Sorghum bicolor, Zea mays, Glycine max, Triticum aestivum, and Brachypodium distachyon. The analysis of conserved motifs and bZIP domains was performed using MEME and PFAM databases...
June 29, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28664971/luminescent-tb-iii-and-sm-iii-complexes-with-a-1-4-7-triazacyclononane-based-tris-aryloxide-ligand-for-high-performance-oxygen-sensors
#14
Hidetaka Nakai, Masafumi Kuyama, Juncheol Seo, Takahiro Goto, Takahiro Matsumoto, Seiji Ogo
Taking advantage of the outstanding oxygen-sensitive luminescence properties of the previously synthesised Tb(iii) complex [{((MeMe)ArO)3tacn}Ln(III)(THF)] (1(Tb), Ln = Tb), herein, we have prepared an oxygen sensor based on 1(Tb) embedded in polystyrene film (1(Tb)/PS) and found that 1(Tb)/PS shows the highest sensitivity (I0/I100 = 14.9) and the fastest response (response/recovery time = 1.9 s/2.9 s), among the lanthanide(iii)-based oxygen sensors with f-f emission. Moreover, we have prepared the lanthanide(iii)-based colorimetric luminescent oxygen sensor (1(TbSm)/PS) with green-yellow-red responses, by using 1(Tb) and a newly synthesised oxygen-insensitive Sm(iii) complex (1(Sm), Ln = Sm; Φ = 0...
July 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28660848/effects-of-rapeseed-meal-fiber-content-on-phosphorus-and-calcium-digestibility-in-growing-pigs-fed-diets-without-or-with-microbial-phytase
#15
M Bournazel, M Lessire, M J Duclos, M Magnin, N Même, C Peyronnet, E Recoules, A Quinsac, E Labussière, A Narcy
The optimization of dietary phosphorus (P) and calcium (Ca) supply requires a better understanding of the effect of dietary fiber content of co-products on the digestive utilization of minerals. This study was designed to evaluate the effects of dietary fiber content from 00-rapeseed meal (RSM) on P and Ca digestibility throughout the gastrointestinal tract in growing pigs fed diets without or with microbial phytase. In total, 48 castrated male pigs (initial BW=36.1±0.4 kg) were housed in metabolic crates for 29 days...
June 29, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28596122/trends-and-regional-variations-in-provision-of-contraception-methods-in-a-commercially-insured-population-in-the-united-states-based-on-nationally-proposed-measures
#16
A Law, J S Yu, W Wang, J Lin, R Lynen
OBJECTIVES: Three measures to assess the provision of effective contraception methods among reproductive-aged women have recently been endorsed for national public reporting. Based on these measures, this study examined real-world trends and regional variations of contraceptive provision in a commercially insured population in the United States. STUDY DESIGN: Women 15-44years old with continuous enrollment in each year from 2005 to 2014 were identified from a commercial claims database...
June 5, 2017: Contraception
https://www.readbyqxmd.com/read/28571483/an-efficient-method-for-significant-motifs-discovery-from-multiple-dna-sequences
#17
Abdulrakeeb M Al-Ssulami, Aqil M Azmi, Hassan Mathkour
Identification of transcription factor binding sites or biological motifs is an important step in deciphering the mechanisms of gene regulation. It is a classic problem that has eluded a satisfactory and efficient solution. In this paper, we devise a three-phase algorithm to mine for biologically significant motifs. In the first phase, we generate all the possible string motifs, this phase is followed by a filtering process where we discard all motifs that do not meet the constraints. And in the final phase, motifs are scored and ranked using a combination of stochastic techniques and [Formula: see text]-value...
May 11, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28475980/comprehensive-comparison-of-two-protein-family-of-p-atpases-13a1-and-13a3-in-insects
#18
Samin Seddigh
The P-type ATPases (P-ATPases) are present in all living cells where they mediate ion transport across membranes on the expense of ATP hydrolysis. Different ions which are transported by these pumps are protons like calcium, sodium, potassium, and heavy metals such as manganese, iron, copper, and zinc. Maintenance of the proper gradients for essential ions across cellular membranes makes P-ATPases crucial for cell survival. In this study, characterization of two families of P-ATPases including P-ATPase 13A1 and P-ATPase 13A3 protein was compared in two different insect species from different orders...
April 15, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28448579/il-33-receptor-st2-regulates-the-cognitive-impairments-associated-with-experimental-cerebral-malaria
#19
Flora Reverchon, Stéphane Mortaud, Maëliss Sivoyon, Isabelle Maillet, Anthony Laugeray, Jennifer Palomo, Céline Montécot, Améziane Herzine, Sandra Meme, William Meme, François Erard, Bernhard Ryffel, Arnaud Menuet, Valérie F J Quesniaux
Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA)-infection reproduces several of these features. We reported recently increased levels of IL-33 protein in brain undergoing ECM and the involvement of IL-33/ST2 pathway in ECM development. Here we show that PbA-infection induced early short term and spatial memory defects, prior to blood brain barrier (BBB) disruption, in wild-type mice, while ST2-deficient mice did not develop cognitive defects...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28427956/curcumin-poly-2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline-formulation-an-improved-penetration-and-biological-effect-of-curcumin-in-f508del-cftr-cell-lines
#20
Cristine Gonçalves, Jean-Pierre Gomez, William Même, Bazoly Rasolonjatovo, David Gosset, Steven Nedellec, Philippe Hulin, Cécile Huin, Tony Le Gall, Tristan Montier, Pierre Lehn, Chantal Pichon, Philippe Guégan, Hervé Cheradame, Patrick Midoux
Neutral amphiphilic triblock ABA copolymers are of great interest to solubilize hydrophobic drugs. We reported that a triblock ABA copolymer consisting of methyl-2-oxazoline (MeOx) and tetrahydrofuran (THF) (MeOx6-THF19-MeOx6) (TBCP2) can solubilize curcumin (Cur) a very hydrophobic molecule exhibiting multiple therapeutic effects but whose insolubility and low stability in water is a major drawback for clinical applications. Here, we provide evidences by flow cytometry and confocal microscopy that Cur penetration in normal and ΔF508-CFTR human airway epithelial cell lines is facilitated by TBCP2...
April 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
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