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https://www.readbyqxmd.com/read/28427956/curcumin-poly-2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline-formulation-an-improved-penetration-and-biological-effect-of-curcumin-in-f508del-cftr-cell-lines
#1
Cristine Gonçalves, Jean-Pierre Gomez, William Même, Bazoly Rasolonjatovo, David Gosset, Steven Nedellec, Philippe Hulin, Cécile Huin, Tony Le Gall, Tristan Montier, Pierre Lehn, Chantal Pichon, Philippe Guégan, Hervé Cheradame, Patrick Midoux
Neutral amphiphilic triblock ABA copolymers are of great interest to solubilize hydrophobic drugs. We reported that a triblock ABA copolymer consisting of methyl-2-oxazoline (MeOx) and tetrahydrofuran (THF) (MeOx6-THF19-MeOx6) (TBCP2) can solubilize curcumin (Cur) a very hydrophobic molecule exhibiting multiple therapeutic effects but whose insolubility and low stability in water is a major drawback for clinical applications. Here, we provide evidences by flow cytometry and confocal microscopy that Cur penetration in normal and ΔF508-CFTR human airway epithelial cell lines is facilitated by TBCP2...
April 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28378191/testing-for-the-occurrence-of-selective-episodes-during-the-divergence-of-otophysan-fishes-insights-from-mitogenomics
#2
Alejandro D'Anatro, Facundo Giorello, Matías Feijoo, Enrique P Lessa
How natural selection shapes biodiversity constitutes a topic of renewed interest during the last few decades. The division Otophysi comprises approximately two-thirds of freshwater fish diversity and probably underwent an extensive adaptive radiation derived from a single invasion of the supercontinent Pangaea, giving place to the evolution of the main five Otophysan lineages during a short period of time. Little is known about the factors involved in the processes that lead to lineage diversification among this group of fishes and identifying directional selection acting over protein-coding genes could offer clues about the processes acting on species diversification...
April 4, 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/28337895/use-of-supercharged-cover-screw-as-static-magnetic-field-generator-for-bone-healing-1st-part-in-vitro-enhancement-of-osteoblast-like-cell-differentiation
#3
F Bambini, A Santarelli, A Putignano, M Procaccini, G Orsini, L Memè, D Sartini, M Emanuelli, L Lo Muzio
Since 1979, Pulsed electromagnetic fields (PEMFs) have been approved by the Food and Drug Administration as an effective method in the treatment of non-unions. As well as PEMFs, also static magnetic fields (SMFs) have been widely investigated in orthopaedic studies. Even if the exact mechanism of action is not well understood, a large number of studies showed specific effects both at cellular and tissue levels. As bone fracture healing and osseointegration share the same biological events, the application of magnetic field stimulation in order to facilitate the osseointegration process has been suggested...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28331573/evolution-of-the-spatula-alcatraz-gene-lineage-and-expression-analyses-in-the-basal-eudicot-bocconia-frutescens-l-papaveraceae
#4
Cecilia Zumajo-Cardona, Barbara Ann Ambrose, Natalia Pabón-Mora
BACKGROUND: SPATULA (SPT) and ALCATRAZ (ALC) are recent paralogs that belong to the large bHLH transcription factor family. Orthologs of these genes have been found in all core eudicots, whereas pre-duplication genes, named paleoSPATULA/ALCATRAZ, have been found in basal eudicots, monocots, basal angiosperms and gymnosperms. Nevertheless, functional studies have only been performed in Arabidopsis thaliana, where SPT and ALC are partially redundant in carpel and valve margin development and ALC has a unique role in the dehiscence zone...
2017: EvoDevo
https://www.readbyqxmd.com/read/28330144/upcot-an-integrated-pipeline-tool-for-clustering-upstream-dna-sequences-of-orthologous-genes-in-prokaryotic-genomes
#5
P V Parvati Sai Arun, Jogadhenu S S Prakash
UpCoT is a pipeline tool developed by automating the series of steps involved in prediction of cis-regulatory elements. UpCoT generates orthologs for each gene in target genome using bi-directional best blast hit against the reference genomes, then identifies potential orthologous transcriptional units using intergenic distance. Finally it generates the FASTA files containing upstream sequences of orthologous transcriptional units of each gene in target genome. The inputs of UpCoT are protein sequence files (*...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28300049/type-i-monteggia-with-ipsilateral-fracture-of-distal-radius-epiphyseal-injury-a-rare-case-report
#6
Gaurav Mundada, Sohael Mohammed Khan, Shraddha K Singhania, Varun Gupta, Pradeep K Singh, Saherish Khan
Simultaneous Monteggia injuries of the elbow and ipsilateral fracture distal radius with epiphyseal injury both bone are a unique case. A unique case of a Type I Monteggia fracture equivalent with ipsilateral fracture distal radius with epiphyseal injury (Salter-Harris Type II) in a child is reported. We describe the management of this unique fracture and discuss the possible mechanism of injury. We have highlighted a rare combination of injuries. Early recognition and prompt surgical intervention can lead to a satisfactory outcome even in these complex injuries...
January 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28276452/de-novo-computational-identification-of-stress-related-sequence-motifs-and-microrna-target-sites-in-untranslated-regions-of-a-plant-translatome
#7
Prabhakaran Munusamy, Yevgen Zolotarov, Louis-Valentin Meteignier, Peter Moffett, Martina V Strömvik
Gene regulation at the transcriptional and translational level leads to diversity in phenotypes and function in organisms. Regulatory DNA or RNA sequence motifs adjacent to the gene coding sequence act as binding sites for proteins that in turn enable or disable expression of the gene. Whereas the known DNA and RNA binding proteins range in the thousands, only a few motifs have been examined. In this study, we have predicted putative regulatory motifs in groups of untranslated regions from genes regulated at the translational level in Arabidopsis thaliana under normal and stressed conditions...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220677/toward-a-sociology-of-oceans
#8
John Hannigan
Despite covering around 70 percent of the earth's surface, the ocean has long been ignored by sociology or treated as merely an extension of land-based systems. Increasingly, however, oceans are assuming a higher profile, emerging both as a new resource frontier, a medium for geopolitical rivalry and conflict, and a unique and threatened ecological hot spot. In this article, I propose a new sociological specialty area, the "sociology of oceans" to be situated at the interface between environmental sociology and traditional maritime studies...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28166541/identification-and-expression-profile-analysis-of-odorant-binding-protein-and-chemosensory-protein-genes-in-bemisia-tabaci-med-by-head-transcriptome
#9
Ran Wang, Fengqi Li, Wei Zhang, Xiaoman Zhang, Cheng Qu, Guillaume Tetreau, Lujuan Sun, Chen Luo, Jingjiang Zhou
Odorant binding proteins (OBPs) and chemosensory proteins (CSPs) of arthropods are thought to be involved in chemical recognition which regulates pivotal behaviors including host choice, copulation and reproduction. In insects, OBPs and CSPs located mainly in the antenna but they have not been systematically characterized yet in Bemisia tabaci which is a cryptic species complex and could damage more than 600 plant species. In this study, among the 106,893 transcripts in the head assembly, 8 OBPs and 13 CSPs were identified in B...
2017: PloS One
https://www.readbyqxmd.com/read/28134358/emergence-of-consensus-as-a-modular-to-nested-transition-in-communication-dynamics
#10
Javier Borge-Holthoefer, Raquel A Baños, Carlos Gracia-Lázaro, Yamir Moreno
Online social networks have transformed the way in which humans communicate and interact, leading to a new information ecosystem where people send and receive information through multiple channels, including traditional communication media. Despite many attempts to characterize the structure and dynamics of these techno-social systems, little is known about fundamental aspects such as how collective attention arises and what determines the information life-cycle. Current approaches to these problems either focus on human temporal dynamics or on semiotic dynamics...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28116966/functional-structural-and-phylogenetic-analysis-of-mitochondrial-cytochrome-b-cytb-in-insects
#11
Samin Seddigh, Maryam Darabi
Cytochrome b (Cytb, EC 1.10. 2.2) is the only cytochrome coded by mitochondrial DNA and involved in electron transport in the mitochondrial respiratory chain. In this study, characterization of cytb protein was identified on fifty-four insect protein sequences, from different orders. According to the conserved motifs obtained with MEME and MAST tools, eight motifs were common to all insects. The structural and functional analyses of 16 selected insects from different orders were performed with ProtParam, Compute PI, SOPMA, SignalP 4...
January 24, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28097693/distinguishing-between-biochemical-and-cellular-function-are-there-peptide-signatures-for-cellular-function-of-proteins
#12
Shruti Jain, Kausik Bhattacharyya, Rachit Bakshi, Ankita Narang, Vani Brahmachari
The genome annotation and identification of gene function depends on conserved biochemical activity. However, in the cell, proteins with the same biochemical function can participate in different cellular pathways and cannot complement one another. Similarly, two proteins of very different biochemical functions are put in the same class of cellular function; for example, the classification of a gene as an oncogene or a tumour suppressor gene is not related to its biochemical function, but is related to its cellular function...
January 18, 2017: Proteins
https://www.readbyqxmd.com/read/28096861/5-8s-rrna-sequence-and-secondary-structure-in-parabronema-skrjabini-and-related-habronematidae-species
#13
Seyed Sajjad Hasheminasab
BACKGROUND: Genomic DNA was isolated from Parabronema skrjabini. rRNA region was amplified and sequenced. METHODS: The RNA secondary structure was predicted using mfold software ( http://mfold.rit.albany.edu ). The secondary structure with bulge, hairpins, helices, interior, external and multi loops was predicted for 5.8srDNA of our sequence of P. skrjabini and a sequence of P. skrjabini and two species of Habronema (H. microstoma and H. muscae) in GenBank. RNA motifs were predicted by MEME program version 4...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28067970/fourier-transform-infrared-imaging-analysis-of-dental-pulp-inflammatory-diseases
#14
E Giorgini, S Sabbatini, C Conti, C Rubini, R Rocchetti, M Fioroni, L Memè, G Orilisi
OBJECTIVES: Fourier Transform Infrared microspectroscopy let characterize the macromolecular composition and distribution of tissues and cells, by studying the interaction between infrared radiation and matter. Therefore, we hypothesize to exploit this analytical tool in the analysis of inflamed pulps, to detect the different biochemical features related to various degrees of inflammation. MATERIALS AND METHODS: IR maps of 13 irreversible and 12 hyperplastic pulpitis, together with 10 normal pulps, were acquired, compared with histological findings and submitted to multivariate (HCA, PCA, SIMCA) and statistical (one-way ANOVA) analysis...
January 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28063572/suppl%C3%A3-mentation-pr%C3%A3-conceptionnelle-en-acide-folique-multivitamines-pour-la-pr%C3%A3-vention-primaire-et-secondaire-des-anomalies-du-tube-neural-et-d-autres-anomalies-cong%C3%A3-nitales-sensibles-%C3%A3-l-acide-folique
#15
R Douglas Wilson
OBJECTIF: Offrir des renseignements à jour sur l'utilisation pré et postconceptionnelle d'acide folique par voie orale, avec ou sans supplément de multivitamines / micronutriments, aux fins de la prévention des anomalies du tube neural et d'autres anomalies congénitales. Ces renseignements aideront les médecins, les sages-femmes, les infirmières et les autres professionnels de la santé à contribuer aux efforts de sensibilisation des femmes quant à l'utilisation et aux posologies adéquates de la supplémentation en acide folique / multivitamines, avant et pendant la grossesse...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28019654/drinking-alcohol-use-disorder-and-treatment-access-and-utilization-among-u-s-racial-ethnic-groups
#16
Patrice A C Vaeth, Meme Wang-Schweig, Raul Caetano
Data from approximately 140 articles and reports published since 2000 on drinking, alcohol use disorder (AUD), correlates of drinking and AUD, and treatment needs, access, and utilization were critically examined and summarized. Epidemiological evidence demonstrates alcohol-related disparities across U.S. racial/ethnic groups. American Indians/Alaska Natives generally drink more and are disproportionately affected by alcohol problems, having some of the highest rates for AUD. In contrast, Asian Americans are less affected...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28018406/structural-evolutionary-and-functional-analysis-of-the-class-iii-peroxidase-gene-family-in-chinese-pear-pyrus-bretschneideri
#17
Yunpeng Cao, Yahui Han, Dandan Meng, Dahui Li, Qing Jin, Yi Lin, Yongping Cai
Peroxidases (PRXs) are widely existed in various organisms and could be divided into different types according to their structures and functions. Specifically, the Class III Peroxidase, a plant-specific multi-gene family, involves in many physiological processes, such as the metabolism of auxin, the extension and thickening of cell wall, as well as the formation of lignin. By searching the pear genome database, 94 non-redundant PRXs from Pyrus bretschneideri (PbPRXs) were identified. Subsequently, analysis of phylogenetic relationships, gene structures, conserved motifs, and microsynteny was performed...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28012942/a-host-protein-based-assay-to-differentiate-between-bacterial-and-viral-infections-in-preschool-children-opportunity-a-double-blind-multicentre-validation-study
#18
Chantal B van Houten, Joris A H de Groot, Adi Klein, Isaac Srugo, Irena Chistyakov, Wouter de Waal, Clemens B Meijssen, Wim Avis, Tom F W Wolfs, Yael Shachor-Meyouhas, Michal Stein, Elisabeth A M Sanders, Louis J Bont
BACKGROUND: A physician is frequently unable to distinguish bacterial from viral infections. ImmunoXpert is a novel assay combining three proteins: tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma induced protein-10 (IP-10), and C-reactive protein (CRP). We aimed to externally validate the diagnostic accuracy of this assay in differentiating between bacterial and viral infections and to compare this test with commonly used biomarkers. METHODS: In this prospective, double-blind, international, multicentre study, we recruited children aged 2-60 months with lower respiratory tract infection or clinical presentation of fever without source at four hospitals in the Netherlands and two hospitals in Israel...
April 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27978455/interfacial-kinetics-in-a-model-emulsion-polymerisation-system-using-microelectrochemical-measurements-at-expanding-droplets-memed-and-time-lapse-microscopy
#19
Elizabeth E Oseland, Anita Rea, Martine I de Heer, Jeffrey D Fowler, Patrick R Unwin
Physicochemical processes that take place at the oil-water interface of an epoxy-amine emulsion polymerisation system influence the properties and structural morphology of the polymeric microparticles formed. Investigating these processes, such as the transport of monomers across the liquid/liquid interface brings new understanding which can be used to tune polymeric morphology. Two different approaches are used to provide new insights on these processes. Microelectrochemical measurements at expanding droplets (MEMED) is used to measure the transfer of amine from an organic phase comprised of epoxide and amine into an aqueous receptor phase...
March 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27951454/kamikazes-and-cultural-evolution
#20
Sean Allen-Hermanson
Is cultural evolution needed to explain altruistic selfsacrifice? Some contend that cultural traits (e.g. beliefs, behaviors, and for some "memes") replicate according to selection processes that have "floated free" from biology. One test case is the example of suicide kamikaze attacks in wartime Japan. Standard biological mechanisms-such as reciprocal altruism and kin selection-might not seem to apply here: The suicide pilots did not act on the expectation that others would reciprocate, and they were supposedly sacrificing themselves for country and emperor, not close relatives...
February 2017: Studies in History and Philosophy of Biological and Biomedical Sciences
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