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https://www.readbyqxmd.com/read/29466990/targeting-her2-breast-tumors-with-scfv-decorated-bimodal-nanoprobes
#1
Christophe Alric, Katel Hervé-Aubert, Nicolas Aubrey, Souad Melouk, Laurie Lajoie, William Même, Sandra Même, Yann Courbebaisse, Anastasia A Ignatova, Alexey V Feofanov, Igor Chourpa, Emilie Allard-Vannier
BACKGROUND: Recent advances in nanomedicine have shown the great interest of active targeting associated to nanoparticles. Single chain variable fragments (scFv) of disease-specific antibodies are very promising targeting entities because they are small, not immunogenic and able to bind their specific antigens. The present paper is devoted to biological properties in vitro and in vivo of fluorescent and pegylated iron oxide nanoparticles (SPIONs-Cy-PEG-scFv) functionalized with scFv targeting Human Epithelial growth Receptor 2 (HER2)...
February 21, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29464462/gestational-and-lactational-exposure-to-dichlorinated-bisphenol-a-induces-early-alterations-of-hepatic-lipid-composition-in-mice
#2
Dounia El Hamrani, Amandine Chepied, William Même, Marc Mesnil, Norah Defamie, Sandra Même
OBJECTIVE: Using non-invasive magnetic resonance (MR) techniques and a histological approach, we assessed the outcomes of perinatal exposure at a low dose of 3,3'-DCBPA (2-chloro-4-[1-(3-chloro-4-hydroxyphenyl)-1-methylethyl]phenol) and/or 3,5-DCBPA (2,6-dichloro-4-[1-(4-hydroxyphenyl)-1-methylethyl]phenol) on mice livers. MATERIALS AND METHODS: Fertilized female Swiss mice were injected intraperitoneally during gestation and lactation with either vehicle control, 20 μg/kg/day of BPA, 3,5-DCBPA, 3,3'-DCBPA or a mixture (mix-DCBPA)...
February 20, 2018: Magma
https://www.readbyqxmd.com/read/29447453/in-silico-genome-wide-identification-and-characterization-of-glutathione-s-transferase-gene-family-in-vigna-radiata-l-wilczek
#3
Swati Vaish, Praveen Awasthi, Siddharth Tiwari, Shailesh Kumar Tiwari, Divya Gupta, Mahesh Kumar Basantani
Plant glutathione S-transferases are integral to normal plant metabolism, and biotic and abiotic stress tolerance. GST gene family has been characterized in diverse plant species using molecular biology and bioinformatics approaches. In the current study, in silico analysis identified 44 GSTs in Vigna radiata. Of the total 44 GSTs identified, chromosomal locations of 31 GSTs were confirmed. The pI value of GST proteins ranged from 5.10 to 9.40. The predicted molecular weights ranged from 13.12 to 50 kDa. Subcellular localization analysis revealed that all GSTs were predominantly localized in the cytoplasm...
February 15, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29446559/the-handaxe-reconsidered
#4
Thomas Wynn, John Gowlett
The Acheulean handaxe is one of the longest-known and longest-surviving artifacts of the Palaeolithic and, despite its experimentally tested functionality, is often regarded as puzzling. It is unnecessary to invoke a unique-for-mammals genetic mechanism to explain the handaxe phenomenon. Instead, we propose that two nongenetic processes are sufficient. The first is a set of ergonomic design principles linked to the production of sturdy, hand-held cutting tools in the context of a knapped-stone technology that lacked hafting...
January 2018: Evolutionary Anthropology
https://www.readbyqxmd.com/read/29411313/myod-and-hand-transcription-factors-have-conserved-recognition-sites-in-mtor-promoter-insights-from-in-silico-analysis
#5
Ankita Awasthi, Vikrant Nain, Rekha Puria
mTOR regulates multiple cellular processes that are critical for proper maintenance of cell growth and development. However, mechanisms and factors responsible for transcriptional regulation of mTOR are partially known. To identify different transcription factor binding sites in promoter region of mTOR, we performed in silico phylogenetic foot printing analysis of diverse set of human orthologs. Phylogenetic tree for the orthologs was generated to establish the evolutionary relationships among them. Conserved binding sites among the species were predicted by tool MEME...
February 6, 2018: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29390641/synergistic-effects-in-threshold-models-on-networks
#6
Jonas S Juul, Mason A Porter
Network structure can have a significant impact on the propagation of diseases, memes, and information on social networks. Different types of spreading processes (and other dynamical processes) are affected by network architecture in different ways, and it is important to develop tractable models of spreading processes on networks to explore such issues. In this paper, we incorporate the idea of synergy into a two-state ("active" or "passive") threshold model of social influence on networks. Our model's update rule is deterministic, and the influence of each meme-carrying (i...
January 2018: Chaos
https://www.readbyqxmd.com/read/29357247/physico-chemical-characterization-of-fine-and-ultrafine-particles-emitted-during-dpf-active-regeneration-of-euro5-diesel-vehicles
#7
Badr R'mili, Antoinette Boreave, Aurelie Meme, Philippe Vernoux, Mickael Leblanc, Ludovic Noel, Stephane Raux, Barbara D'Anna
Diesel Particulate Filters (DPFs) are commonly employed in modern passenger cars to comply with current particulate matter (PM) emission standards. DPFs requires periodic regeneration to remove the accumulated matter. During the process high concentration particles both in nucleation and accumulation mode are emitted. Here we report new information on particle morphology and chemical composition of fine (FPs) and ultrafine particles (UFPs) measured downstream of the Diesel Particulate Filters (DPF) during active regeneration of two Euro 5 passenger cars...
January 22, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29330771/inhibition-of-human%C3%A2-immunodeficiency-type-1-virus-hiv-1-life-cycle-by-different-egg-white-lysozymes
#8
Mandana Behbahani, Mokhtar Nosrati, Hassan Mohabatkar
Lysozyme is a relatively small enzyme with different biological activities, which is found in tears, saliva, egg white, and human milk. In the study, the anti-HIV-1 activity of lysozymes purified from quail, Meleagris, and hen egg white has been determined. For this end, a time-of-drug-addition assay was performed to identify the target of anti-HIV-1 agents and for determination of probable anti HIV-1 mechanism of the studied lysozyme, the binding affinity of the lysozymes to the human CD4 receptor was studied by molecular docking method...
January 13, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29312534/the-pax8-cistrome-in-epithelial-ovarian-cancer
#9
Emily K Adler, Rosario I Corona, Janet M Lee, Norma Rodriguez-Malave, Paulette Mhawech-Fauceglia, Heidi Sowter, Dennis J Hazelett, Kate Lawrenson, Simon A Gayther
PAX8 is a lineage-restricted transcription factor that is expressed in epithelial ovarian cancer (EOC) precursor tissues, and in the major EOC histotypes. Frequent overexpression of PAX8 in primary EOCs suggests this factor functions as an oncogene during tumorigenesis, however, the biological role of PAX8 in EOC development is poorly understood. We found that stable knockdown of PAX8 in EOC models significantly reduced cell proliferation and anchorage dependent growth in vitro, and attenuated tumorigenicity in vivo...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310678/computational-analysis-of-envelope-glycoproteins-from-diverse-geographical-isolates-of-bovine-leukemia-virus-identifies-highly-conserved-peptide-motifs
#10
Aneta Pluta, Lorraine M Albritton, Marzena Rola-Łuszczak, Jacek Kuźmak
BACKGROUND: Bovine leukemia virus (BLV) is a deltaretrovirus infecting bovine B cells and causing enzootic bovine leucosis. The SU or surface subunit, gp51, of its envelope glycoprotein is involved in receptor recognition and virion attachment. It contains the major neutralizing and CD4+ and CD8+ T cell epitopes found in naturally infected animals. In this study, we aimed to determine global variation and conservation within gp51 in the context of developing an effective global BLV vaccine...
January 8, 2018: Retrovirology
https://www.readbyqxmd.com/read/29298679/sequence-motif-finder-using-memetic-algorithm
#11
Jader M Caldonazzo Garbelini, André Y Kashiwabara, Danilo S Sanches
BACKGROUND: De novo prediction of Transcription Factor Binding Sites (TFBS) using computational methods is a difficult task and it is an important problem in Bioinformatics. The correct recognition of TFBS plays an important role in understanding the mechanisms of gene regulation and helps to develop new drugs. RESULTS: We here present Memetic Framework for Motif Discovery (MFMD), an algorithm that uses semi-greedy constructive heuristics as a local optimizer. In addition, we used a hybridization of the classic genetic algorithm as a global optimizer to refine the solutions initially found...
January 3, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29258562/leishmania-infantum-5-methylthioadenosine-phosphorylase-presents-relevant-structural-divergence-to-constitute-a-potential-drug-target
#12
Hela Abid, Emna Harigua-Souiai, Thouraya Mejri, Mourad Barhoumi, Ikram Guizani
BACKGROUND: The 5'-methylthioadenosine phosphorylase (MTAP), an enzyme involved in purine and polyamine metabolism and in the methionine salvage pathway, is considered as a potential drug target against cancer and trypanosomiasis. In fact, Trypanosoma and Leishmania parasites lack de novo purine pathways and rely on purine salvage pathways to meet their requirements. Herein, we propose the first comprehensive bioinformatic and structural characterization of the putative Leishmania infantum MTAP (LiMTAP), using a comparative computational approach...
December 19, 2017: BMC Structural Biology
https://www.readbyqxmd.com/read/29236254/integration-of-encode-rnaseq-and-eclip-data-sets
#13
Jorge Boucas
During the last decade, the study of mRNA decay has largely benefited from an increasing number of high-throughput assays that emerged from developments in next generation sequencing (NGS) technologies as well as mass spectrometry. While assay-specific data analysis is often reported and software made available many researchers struggle with the overwhelming challenge of integrating data from diverse assays, different sources, and of different formats.We here use Python, R, and bash to analyze and integrate RNAseq and eCLIP data publicly available from ENCODE...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29235827/nursing-memes-at-odds-with-our-values
#14
David Kenneth Wright
No abstract text is available yet for this article.
March 2017: Canadian Nurse
https://www.readbyqxmd.com/read/29197337/genome-wide-motif-predictions-of-bcarr-box-in-the-amino-acid-repressed-genes-of-lactobacillus-helveticus-cm4
#15
Naoyuki Yamamoto, Taketo Wakai
BACKGROUND: A BCARR (branched-chain amino acid responsive repressor) identified in proteolytic gene expressions in Lactobacillus helveticus is considered to negatively control transcriptions by binding to operator sites at the promoter regions in the presence of BCAAs. However, the distributions and regulatory potential of the BCARR in all genes repressed by BCAAs in CM4 remains unclear. RESULTS: A genome-wide search for the BCARR-box was conducted to clarify the contribution of BCARR in the regulation of amino acid metabolism in L...
December 2, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29172702/using-panel-vendors-for-recruitment-into-a-web-based-family-prevention-program-methodological-considerations
#16
Meme Wang-Schweig, Brenda A Miller, David B Buller, Hilary F Byrnes, Beth Bourdeau, Veronica Rogers
Use of online panel vendors in research has grown over the past decade. Panel vendors are organizations that recruit participants into a panel to take part in web-based surveys and match panelists to a target audience for data collection. We used two panel vendors to recruit families ( N = 411) with a 16- to 17-year-old teen to participate in a randomized control trial (RCT) of an online family-based program to prevent underage drinking and risky sexual behaviors. Our article addresses the following research questions: (1) How well do panel vendors provide a sample of families who meet our inclusion criteria to participate in a RCT? (2) How well do panel vendors provide a sample of families who reflect the characteristics of the general population? and (3) Does the choice of vendor influence the characteristics of families that we engage in research? Despite the screening techniques used by the panel vendors to identify families who met our inclusion criteria, 23...
January 1, 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/29138946/semiotic-systems-with-duality-of-patterning-and-the-issue-of-cultural-replicators
#17
Gerhard Schaden, Cédric Patin
Two major works in recent evolutionary biology have in different ways touched upon the issue of cultural replicators in language, namely Dawkins' Selfish Gene and Maynard Smith and Szathmáry's Major Transitions in Evolution. In the latter, the emergence of language is referred to as the last major transition in evolution (for the time being), a claim we argue to be derived from a crucial property of language, called Duality of Patterning. Prima facie, this property makes natural language look like a structural equivalent to DNA, and its peer in terms of expressive power...
November 14, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29018527/british-thoracic-society-quality-standards-for-home-oxygen-use-in-adults
#18
Jay Suntharalingam, Tom Wilkinson, Joseph Annandale, Claire Davey, Rhea Fielding, Daryl Freeman, Michael Gibbons, Maxine Hardinge, Sabrine Hippolyte, Vikki Knowles, Cassandra Lee, William MacNee, Jacqueline Pollington, Vandana Vora, Trefor Watts, Meme Wijesinghe
INTRODUCTION: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for home oxygen provision in the UK, together with measurable markers of good practice. Quality statements are based on the British Thoracic Society (BTS) Guideline for Home Oxygen Use in Adults. METHODS: Development of BTS Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28970488/single-cell-analysis-reveals-sexually-dimorphic-repertoires-of-interferon-%C3%AE-and-il-17a-producing-t-cells-in-salivary-glands-of-sj%C3%A3-gren-s-syndrome-mice
#19
Arun Wanchoo, Alexandria Voigt, Sukesh Sukumaran, Carol M Stewart, Indraneel Bhattacharya, Cuong Q Nguyen
The development of Sjögren's syndrome (SjS) is a dynamic and temporal process with a female predilection. Following the initial influx of immune cells, T cell clusters develop, accelerating the pathology in the salivary glands. Proinflammatory cytokines, IFN-γ and IL-17A, produced by T cells contribute synergistically to the disease. In this study, we examined the sexual dimorphism in cellular infiltrates of the salivary glands by using functional single-cell microengraving analysis. Using high-throughput sequencing, we investigated the clonal diversity of the T cell receptors (TCRs) of infiltrating IFN-γ and IL-17A-producing T cells in male and female SjS-susceptible (SjS(s)) C57BL/6...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851488/membrane-enclosed-multienzyme-meme-synthesis-of-2-7-anhydro-sialic-acid-derivatives
#20
Marie Monestier, Dimitrios Latousakis, Andrew Bell, Sandra Tribolo, Louise E Tailford, Ian J Colquhoun, Gwenaelle Le Gall, Hai Yu, Xi Chen, Martin Rejzek, Simone Dedola, Robert A Field, Nathalie Juge
Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases). A facile one-pot two-enzyme approach has been established for the synthesis of 2,7-anhydro-sialic acid derivatives including those containing different sialic acid forms such as Neu5Ac and N-glycolylneuraminic acid (Neu5Gc). The approach is based on the use of Ruminoccocus gnavus IT-sialidase for the release of 2,7-anhydro-sialic acid from glycoproteins, and the conversion of free sialic acid by a sialic acid aldolase...
November 8, 2017: Carbohydrate Research
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