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https://www.readbyqxmd.com/read/27921034/crowdsourcing-precision-cerebrovascular-health-imaging-and-cloud-seeding-a-million-brains-initiative%C3%A2
#1
David S Liebeskind
Crowdsourcing, an unorthodox approach in medicine, creates an unusual paradigm to study precision cerebrovascular health, eliminating the relative isolation and non-standardized nature of current imaging data infrastructure, while shifting emphasis to the astounding capacity of big data in the cloud. This perspective envisions the use of imaging data of the brain and vessels to orient and seed A Million Brains Initiative™ that may leapfrog incremental advances in stroke and rapidly provide useful data to the sizable population around the globe prone to the devastating effects of stroke and vascular substrates of dementia...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27918944/groundwater-nitrate-pollution-and-human-health-risk-assessment-by-using-hhra-model-in-an-agricultural-area-ne-china
#2
Yuanzheng Zhai, Xiaobing Zhao, Yanguo Teng, Xiao Li, Junjun Zhang, Jin Wu, Rui Zuo
In order to learn the pollution circumstance of groundwater nitrate detailedly in Songnen Plain of Northeast China and estimate its potential risk to human health of local residents, a total of 389 groundwater samples were collected in 2014 and studied from residential areas and public water supply wells in 11 cities and counties in southeastern of Songnen Plain. The analysis results showed that the spatial distributions of main chemical components in groundwater had great variations with statistical concentrations in the order of TDS> HCO3> Ca> NO3> Cl> Na> SO4> Mg> K> NH4> NO2...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27916807/task-and-participant-scheduling-of-trading-platforms-in-vehicular-participatory-sensing-networks
#3
Heyuan Shi, Xiaoyu Song, Ming Gu, Jiaguang Sun
The vehicular participatory sensing network (VPSN) is now becoming more and more prevalent, and additionally has shown its great potential in various applications. A general VPSN consists of many tasks from task, publishers, trading platforms and a crowd of participants. Some literature treats publishers and the trading platform as a whole, which is impractical since they are two independent economic entities with respective purposes. For a trading platform in markets, its purpose is to maximize the profit by selecting tasks and recruiting participants who satisfy the requirements of accepted tasks, rather than to improve the quality of each task...
November 28, 2016: Sensors
https://www.readbyqxmd.com/read/27913245/contextual-computing-a-bluetooth-based-approach-for-tracking-healthcare-providers-in-the-emergency-room
#4
Joshua Frisby, Vernon Smith, Stephen Traub, Vimla L Patel
Hospital Emergency Departments (EDs) frequently experience crowding. One of the factors that contributes to this crowding is the "door to doctor time", which is the time from a patient's registration to when the patient is first seen by a physician. This is also one of the Meaningful Use (MU) performance measures that emergency departments report to the Center for Medicare and Medicaid Services (CMS). Current documentation methods for this measure are inaccurate due to the imprecision in manual data collection...
November 29, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27913095/soft-hard-tissues-and-pharyngeal-airway-volume-changes-following-maxillomandibular-transverse-osteodistraction-computed-tomography-and-three-dimensional-laser-scanner-evaluation
#5
Francesca Antonella Bianchi, Giovanni Gerbino, Marina Corsico, Eleonora Schellino, Niccolò Barla, Laura Verzè, Guglielmo Ramieri
INTRODUCTION: Maxillomandibular transverse osteodistraction (MMTOD) is an alternative approach to the traditional treatment for transverse maxillary and mandibular deficiencies and crowding. The aim was to report soft and hard-tissues changes and airway volume variation. METHODS: In this study, skeletally mature, non-syndromic patients with transverse maxillary and mandibular hypoplasia, who underwent a MMTOD between 2010 and 2012, were included. Surgical changes were analysed using clinical evaluation, three-dimensional facial surface data and computed tomography analysis before (T0) and after the completion of post-op orthodontic treatment (T1)...
October 18, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27908016/bistable-gaits-and-wobbling-induced-by-pedestrian-bridge-interactions
#6
Igor V Belykh, Russell Jeter, Vladimir N Belykh
Several modern footbridges around the world have experienced large lateral vibrations during crowd loading events. The onset of large-amplitude bridge wobbling has generally been attributed to crowd synchrony; although, its role in the initiation of wobbling has been challenged. To study the contribution of a single pedestrian into overall, possibly unsynchronized, crowd dynamics, we use a bio-mechanically inspired inverted pendulum model of human balance and analyze its bi-directional interaction with a lively bridge...
November 2016: Chaos
https://www.readbyqxmd.com/read/27907884/factors-determining-human-to-human-transmissibility-of-zoonotic-pathogens-via-contact
#7
REVIEW
Mathilde Richard, Sascha Knauf, Philip Lawrence, Alison E Mather, Vincent J Munster, Marcel A Müller, Derek Smith, Thijs Kuiken
The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high viral load, low infectious dose, crowding, promiscuity, and co-infections; other factors were specific for a pathogen or mode of contact transmission...
November 28, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27907112/role-of-heterogeneous-macromolecular-crowding-and-geometrical-irregularity-at-central-excitatory-synapses-in-shaping-synaptic-transmission
#8
Rahul Gupta, Melissa Reneaux, Karmeshu
Besides the geometrical tortousity due to the extrasynaptic structures, macromolecular crowding and geometrical irregularities constituting the cleft composition at central excitatory synapses has a major and direct role in retarding the glutamate diffusion within the cleft space. However, the cleft composition may not only coarsely reduce the overall diffusivity of the glutamate but may also lead to substantial spatial variation in the diffusivity across the cleft space. Decrease in the overall diffusivity of the glutamate may have straightforward consequences to the glutamate transients in the cleft...
2016: PloS One
https://www.readbyqxmd.com/read/27906410/ion-specificities-of-artificial-macromolecules
#9
REVIEW
Lvdan Liu, Ran Kou, Guangming Liu
Artificial macromolecules are well-defined synthetic polymers, with a relatively simple structure as compared to naturally occurring macromolecules. This review focuses on the ion specificities of artifical macromolecules. Ion specificities are influenced by solvent-mediated indirect ion-macromolecule interactions and also by direct ion-macromolecule interactions. In aqueous solutions, the role of water-mediated indirect ion-macromolecule interactions will be discussed. The addition of organic solvents to aqueous solutions significantly changes the ion specificities due to the formation of water-organic solvent complexes...
September 2, 2016: Soft Matter
https://www.readbyqxmd.com/read/27903808/setting-up-crowd-science-projects
#10
Kaja Scheliga, Sascha Friesike, Cornelius Puschmann, Benedikt Fecher
Crowd science is scientific research that is conducted with the participation of volunteers who are not professional scientists. Thanks to the Internet and online platforms, project initiators can draw on a potentially large number of volunteers. This crowd can be involved to support data-rich or labour-intensive projects that would otherwise be unfeasible. So far, research on crowd science has mainly focused on analysing individual crowd science projects. In our research, we focus on the perspective of project initiators and explore how crowd science projects are set up...
November 29, 2016: Public Understanding of Science
https://www.readbyqxmd.com/read/27903250/effectiveness-of-bovine-derived-xenograft-versus-bioactive-glass-with-periodontally-accelerated-osteogenic-orthodontics-in-adults-a-randomized-controlled-clinical-trial
#11
Maha A Bahammam
BACKGROUND: Periodontally accelerated osteogenic orthodontics (PAOO) combines periodontal therapy with orthodontic therapy, which minimises treatment time. This study compared the effectiveness of a bovine-derived xenograft with that of bioactive glass when combined with PAOO for the treatment of adult patients with moderate crowding of the teeth. METHODS: In this prospective, single-masked clinical trial, 33 orthodontic patients (20 women, 13 men; mean age 21.2 ± 1...
November 30, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27899713/when-do-individuals-with-autism-spectrum-disorder-show-superiority-in-visual-search
#12
Aya Shirama, Nobumasa Kato, Makio Kashino
Although superior visual search skills have been repeatedly reported for individuals with autism spectrum disorder, the underlying mechanisms remain controversial. To specify the locus where individuals with autism spectrum disorder excel in visual search, we compared the performance of autism spectrum disorder adults and healthy controls in briefly presented search tasks, where the search display was replaced by a noise mask at a stimulus-mask asynchrony of 160 ms to interfere with a serial search process while bottom-up visual processing remains intact...
November 29, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27897988/reciprocally-benefited-secure-transmission-for-spectrum-sensing-based-cognitive-radio-sensor-networks
#13
Dawei Wang, Pinyi Ren, Qinghe Du, Li Sun, Yichen Wang
The rapid proliferation of independently-designed and -deployed wireless sensor networks extremely crowds the wireless spectrum and promotes the emergence of cognitive radio sensor networks (CRSN). In CRSN, the sensor node (SN) can make full use of the unutilized licensed spectrum, and the spectrum efficiency is greatly improved. However, inevitable spectrum sensing errors will adversely interfere with the primary transmission, which may result in primary transmission outage. To compensate the adverse effect of spectrum sensing errors, we propose a reciprocally-benefited secure transmission strategy, in which SN's interference to the eavesdropper is employed to protect the primary confidential messages while the CRSN is also rewarded with a loose spectrum sensing error probability constraint...
November 25, 2016: Sensors
https://www.readbyqxmd.com/read/27897388/unprecedented-reaction-pathway-of-sterically-crowded-calcium-complexes-sequential-c-n-bond-cleavages-induced-by-c-h-bond-activations
#14
Yang Yang, Haobing Wang, Haiyan Ma
Five bis(quinolylmethyl)-(1H-indolylmethyl)amine (BQIA) compounds-{(quinol-8-yl-CH2)2NCH2(3-Br-1H-Indol-2-yl)} (L1H) and {[(8-R3-quinol-2-yl)CH2]2NCH(R2)[3-R1-1H-Indol-2-yl]} (L2-5H) (L2H: R1 = Br, R2 = H, R3 = H; L3H: R1 = Br, R2 = H, R3 = iPr; L4H: R1 = H, R2 = CH3, R3 = iPr; L5H: R1 = H, R2 = nBu, R3 = iPr)-have been synthesized and used to prepare calcium complexes. The reactions of L1-5H with silylamido calcium precursors (Ca[N(SiMe2R)2]2(THF)2, R = Me or H) at room temperature gave heteroleptic products (L1-2)CaN(SiMe3)2 (1, 2), (L3-4)CaN(SiHMe2)2 (3a, 4a) and homoleptic complexes (L3,5)2Ca (D3, D5)...
November 29, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27897366/active-site-crowding-of-p450-3a4-as-a-strategy-to-alter-its-selectivity
#15
Paolo Schiavini, Kin J Cheong, Nicolas Moitessier, Karine Auclair
Substrate promiscuous enzymes are a promising starting point for the development of versatile biocatalysts. In this study, human cytochrome P450 3A4, known for its ability to metabolize hundreds of drugs, was engineered to alter its regio- and stereoselectivity. Rational mutagenesis was used to specifically introduce steric hindrance in the large active site of P450 3A4 and favour oxidation at a more sterically accessible position on the substrate. Hydroxylation of a synthetic precursor of (R)-lisofylline, a compound under investigation for its anti-inflammatory properties, was chosen as a first proof-of-principle application of our protein engineering strategy...
November 29, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27897200/lipid-ii-independent-antimicrobial-mechanism-of-nisin-depends-on-its-crowding-and-degree-of-oligomerization
#16
Ashutosh Prince, Padmani Sandhu, Pankaj Kumar, Eva Dash, Shingarika Sharma, Manoranjan Arakha, Suman Jha, Yusuf Akhter, Mohammed Saleem
Nisin inhibits bacterial growth by generating pores in cell membrane and interrupting cell-wall biosynthesis through specific lipid II interaction. However, the role of the hinge region and C-terminus residues of the peptide in antibacterial action of nisin is largely unknown. Here, using molecular dynamics simulations and experimental approach, we report that at high concentration regimes of nisin, interaction with phospholipids may equally deform the bacterial cell membranes even under significantly varying amounts of lipid-II...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893768/macromolecular-crowding-regulates-the-gene-expression-profile-by-limiting-diffusion
#17
Mahdi Golkaram, Stefan Hellander, Brian Drawert, Linda R Petzold
We seek to elucidate the role of macromolecular crowding in transcription and translation. It is well known that stochasticity in gene expression can lead to differential gene expression and heterogeneity in a cell population. Recent experimental observations by Tan et al. have improved our understanding of the functional role of macromolecular crowding. It can be inferred from their observations that macromolecular crowding can lead to robustness in gene expression, resulting in a more homogeneous cell population...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27893367/interactive-crowd-behavior-learning-for-surveillance-and-training
#18
Aniket Bera, Sujeong Kim, Dinesh Manocha
The proposed interactive crowd-behavior learning algorithms can be used to analyze crowd videos for surveillance and training applications. The authors' formulation combines online tracking algorithms from computer vision, nonlinear pedestrian motion models from computer graphics, and machine learning techniques to automatically compute trajectory-level pedestrian behaviors for each agent in the video. These learned behaviors are used to automatically detect anomalous behaviors, perform motion segmentation, and generate realistic behaviors for virtual reality training applications...
November 2016: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/27893077/a-general-account-of-peripheral-encoding-also-predicts-scene-perception-performance
#19
Krista A Ehinger, Ruth Rosenholtz
People are good at rapidly extracting the "gist" of a scene at a glance, meaning with a single fixation. It is generally presumed that this performance cannot be mediated by the same encoding that underlies tasks such as visual search, for which researchers have suggested that selective attention may be necessary to bind features from multiple preattentively computed feature maps. This has led to the suggestion that scenes might be special, perhaps utilizing an unlimited capacity channel, perhaps due to brain regions dedicated to this processing...
January 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27891478/customized-modified-haas-palatal-expansion-in-mixed-dentition-a-case-report
#20
Ziauddin Mohammad, Sampath Reddy Cheruku, Sarada Penmetcha, Srinivas Namineni, Phani Himaja Devi Vaaka
The dental arch perimeter and transpalatal width are the most significant arch dimensions in the developing individuals. Its management during the primary, mixed and early permanent dentition are greatly important for the normal development of the dental arches and significantly improve the occlusion in adulthood. Malocclusion is a constant source of threat to the facial appearance. Severe anterior crowding and narrow maxillary arches adversely affect the smile, facial profile and consequently patient becomes handicapped socially as well as psychologically...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
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