Roman Thaler, Farzaneh Khani, Ines Sturmlechner, Sharareh S Dehghani, Janet M Denbeigh, Xianhu Zhou, Oksana Pichurin, Amel Dudakovic, Sofia S Jerez, Jian Zhong, Jeong-Heon Lee, Ramesh Natarajan, Ivo Kalajzic, Yong-Hui Jiang, David R Deyle, Eleftherios P Paschalis, Barbara M Misof, Tamas Ordog, Andre J van Wijnen
Vitamin C deficiency disrupts the integrity of connective tissues including bone. For decades this function has been primarily attributed to Vitamin C as a cofactor for collagen maturation. Here, we demonstrate that Vitamin C epigenetically orchestrates osteogenic differentiation and function by modulating chromatin accessibility and priming transcriptional activity. Vitamin C regulates histone demethylation (H3K9me3 and H3K27me3) and promotes TET-mediated 5hmC DNA hydroxymethylation at promoters, enhancers and super-enhancers near bone-specific genes...
October 6, 2022: Nature Communications