Read by QxMD icon Read


Fernando Pereira Pérez, Pablo Calvo Espino, Alejandro Sánchez Arteaga, Joaquín Manuel Muñoz Rodriguez, Lionel W Nges, Mireille Kemmoe, Mercedes Vidal Fernández, Francisco Javier Blázquez, Teresa Vives Espejo-Saavedra, Marina Picón Maroñas, Andrés Varela de Ugarte
INTRODUCTION: The aim of this study is to demonstrate our experience at a volunteer surgical program in Cameroon, which is of special interest given to the inability to adopt international treatment guidelines for thyroid surgery in areas of limited resources due to the lack of preoperative testing and to the difficulty to obtain sustitutive hormonal treatment. METHODS: This is a prospective observational study that includes 16 cases of thyroid surgery in Dschang (Cameroon) during June 2015...
August 2016: Cirugía Española
Miles D Thompson, Geoffrey N Hendy, Maire E Percy, Daniel G Bichet, David E C Cole
Genetic variations in G protein-coupled receptor genes (GPCRs) disrupt GPCR function in a wide variety of human genetic diseases. In vitro strategies and animal models have been used to identify the molecular pathologies underlying naturally occurring GPCR mutations. Inactive, overactive, or constitutively active receptors have been identified that result in pathology. These receptor variants may alter ligand binding, G protein coupling, receptor desensitization and receptor recycling. Receptor systems discussed include rhodopsin, thyrotropin, parathyroid hormone, melanocortin, follicle-stimulating hormone (FSH), luteinizing hormone, gonadotropin-releasing hormone (GNRHR), adrenocorticotropic hormone, vasopressin, endothelin-β, purinergic, and the G protein associated with asthma (GPRA or neuropeptide S receptor 1 (NPSR1))...
2014: Methods in Molecular Biology
Ziqiang Yuan, Evan E Opas, Chakravarthy Vrikshajanani, Steven K Libutti, Michael A Levine
Glial cells missing homolog 2 (GCM2) is a transcription factor that is expressed predominately in the pharyngeal pouches and, at later stages, in the developing and mature parathyroid glands. In humans, loss of GCM2 function, either through recessive apomorphic mutations or dominant inhibitor mutations in the human GCM2 gene, leads to isolated hypoparathyroidism. In mice, homozygous disruption of Gcm2 by conventional gene targeting results in parathyroid aplasia and hypoparathyroidism. In this study, we report the generation and functional characterization of mice encoding a conditional null allele of Gcm2...
August 2014: Transgenic Research
Larissa Almenara Silva dos Santos, Vilma Blondet de Azeredo, Diane Eloy Chaves Barbosa, Solange Augusta de Sá
UNLABELLED: The aim of the study was to evaluate the seric ions level and its relationship with Premenstrual Syndrome (PMS) symptoms in young women. METHOD: Ninety-three volunteers were monitored for three months. The nutritional status evaluation was based on BMI. Three "maps of daily symptoms" were used to investigate the frequency of the SPM symptoms. The biochemical evaluation was done in the first month in the luteal phase. The levels of sodium, potassium, calcium, magnesium were determined by colorimetric methods...
November 2013: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Xianmei Meng, David J Baylink, Matilda Sheng, Hongjie Wang, Daila S Gridley, K-H William Lau, Xiao-Bing Zhang
Fibroblast growth factor-2 (FGF2) has been demonstrated to be a promising osteogenic factor for treating osteoporosis. Our earlier study shows that transplantation of mouse Sca-1(+) hematopoietic stem/progenitor cells that are engineered to express a modified FGF2 leads to considerable endosteal/trabecular bone formation, but it also induces adverse effects like hypocalemia and osteomalacia. Here we report that the use of an erythroid specific promoter, β-globin, leads to a 5-fold decrease in the ratio of serum FGF2 to the FGF2 expression in the marrow cavity when compared to the use of a ubiquitous promoter spleen focus-forming virus (SFFV)...
2012: PloS One
Kerry A Daly, Matthew Wolf, Scott A Johnson, Stephen F Badylak
Peripheral compartment syndrome (PCS) has a complex etiology, with limited treatment options and high patient morbidity. Animal models of PCS have been hampered by differences in cross-species anatomy, physiology, and the relative rarity of the naturally occurring syndrome in animals. In the present study, the combination of saline infusion with intermittent crushing of skeletal muscle consistently caused increased intracompartmental pressure, hypocalemia, and hypercreatinine-phophokinasemia, signs diagnostic of PCS...
June 2011: Tissue Engineering. Part C, Methods
Linda Youngwirth, Joy Benavidez, Rebecca Sippel, Herbert Chen
BACKGROUND: Parathyroid hormone (PTH) deficiency or hypoparathyroidism after total thyroidectomy is not an uncommon postoperative complication. Patients who have PTH deficiency will develop profound hypocalcemia if not properly treated with oral calcium supplementation and activated vitamin D (1,25-dihydroxycholecalciferol or calcitriol). However, there is little published on the long-term outcomes of these patients. The aim of this study was to determine the incidence of PTH deficiency and the time course to resolution after total thyroidectomy...
September 2010: Journal of Surgical Research
Akkas Camkurt Meltem, Coskun Figen, Metin Aksu Nalan, Kunt Mahir, Bozkurt Sebnem, Isildak Mehlika, Kilic Ahmet Kasim, Bayraktar Miyase
A 21-year-old male presented to the emergency department with the complaint of muscle weakness. The patient had used a powderized over-the-counter product named 'Tekumut' for 2 weeks to quit smoking. The granulated product was studied and determined to contain 'licorice' containing glycyrrhizic acid.Licorice (a plant which contain glycyrrhizic acid) -induced hypokalemia usually has a mild progression. However, it may cause a critical failure in physical action by means of weakness followed by paralysis and may cause rhabdomyolysis or ventricular fibrillation, leading to death, when left untreated...
2009: Cases Journal
Manpreet K Chadha, Lili Tian, Terry Mashtare, Valencia Payne, Carrie Silliman, Ellis Levine, Michael Wong, Candace Johnson, Donald L Trump
BACKGROUND: Preclinical data indicate that there is substantial antitumor activity and synergy between calcitriol and dexamethasone. On the basis of these data, the authors conducted a phase 2 trial of intravenous (iv) calcitriol at a dose of 74 microg weekly (based on a recent phase 1 trial) and dexamethasone in patients with castration-resistant prostate cancer (CRPC). METHODS: A 2-stage Kepner-Chang design was used. Oral dexamethasone at a dose of 4 mg was given weekly on Days 1 and 2, and iv calcitriol (74 microg over 1 hour) was administered weekly on Day 2 from 4 to 8 hours after the dexamethasone dose in patients with CRPC...
May 1, 2010: Cancer
Jaro Wex, Mark Connolly, Werner Rath
BACKGROUND: The use of tocolytics is central in delaying birth; however, therapeutic options vary in effectiveness and adverse events profiles, which in turn could have consequences for medical resource use and cost of treatment. Betamimetics are commonly used tocolytic agents, but their mechanism of action affects multiple organ systems leading to numerous adverse events. The availability of an oxytocin receptor antagonist, specific for prevention of preterm labour, offers a treatment option that merits further evaluation...
2009: BMC Pregnancy and Childbirth
Miles D Thompson, Maire E Percy, W McIntyre Burnham, David E C Cole
Genetic variation in G protein-coupled receptors (GPCRs) results in the disruption of GPCR function in a wide variety of human genetic diseases. In vitro strategies have been used to elucidate the molecular pathologies that underlie naturally occurring GPCR mutations. Various degrees of inactive, overactive, or constitutively active receptors have been identified. These mutations often alter ligand binding, G protein coupling, receptor desensitization, and receptor recycling. The role of inactivating and activating calcium-sensing receptor (CASR) mutations is discussed with respect to familial hypocalciuric hypercalemia (FHH) and autosomal dominant hypocalemia (ADH)...
2008: Methods in Molecular Biology
Sandra Amaral, Paulo J Oliveira, João Ramalho-Santos
Diabetes Mellitus (DM), a state of chronic hyperglycemia, is a major cause of serious micro and macrovascular diseases, affecting, therefore, nearly every system in the body. Growing evidence indicates that oxidative stress is increased in diabetes due to overproduction of reactive oxygen species (ROS) and decreased efficiency of antioxidant defences, a process that starts very early and worsens over the course of the disease. During the development of diabetes, oxidation of lipids, proteins and DNA increase with time...
February 2008: Current Diabetes Reviews
Steven K Burke
Hyperphosphatemia is one of the more prevalent metabolic disturbances in kidney failure. Phosphate can be considered a uremic toxin based on the accumulation of phosphate during chronic kidney disease, the effects of phosphate on biological systems, and the adverse effects of hyperphosphatemia. The renal clearance of phosphate is maintained until later stages of chronic kidney disease, when the remaining nephrons are no longer able to excrete sufficient phosphate to offset dietary phosphate absorption. Clearance of phosphate by conventional forms of dialysis is insufficient to prevent hyperphosphatemia in most endstage kidney-disease patients...
January 2008: Journal of Renal Nutrition
V Spustová, R Dzúrik
The main source of vitamin D in a man is its synthesis in human skin. 7-Dehydrocholesterol converts into cholecalciferol--vitamin D3--as a result of UV radiation. Cholecalciferol hydroxylates in liver into 25-hydroxyvitamin D3 [25(OH)D, calcidiol], which concentration in blood is a relevant indicator of the total of vitamin D in a human body. 25(OH)D hydroxylates in kidneys into 1,25-dihydroxyvitamin D3 [1,25(OH)2D, calcitriol], which is considered an active metabolite of vitamin D. Epidemiological studies showed high prevalence of low concentrations of 25(OH)D especially in older population and people with chronic diseases...
July 2004: Vnitr̆ní Lékar̆ství
P Vachvanichsanong, P Dissaneewate, W Mitarnun
We report three children with tubulointerstitial renal failure following leptospirosis. All had acute nonoliguric renal failure with mild hypocalemia and mild metabolic acidosis. Maximum blood urea nitrogen (BUN) and creatinine were 217 and 7.1 mg/dl, respectively, on the 6th day of disease, and no patient required dialysis. They presented with acute febrile illness and dehydration, and required intravenous fluid supplements. Myalgia, vomiting, and bleeding were found in two children. Abdominal pain, arthralgia, diarrhea, and conjunctival suffusion were found in one child...
October 1999: Pediatric Emergency Care
C Y Lo, K Y Lam
BACKGROUND: Permanent hypoparathyroidism is a recognized complication of thyroidectomy. Apart from preservation of parathyroid glands in situ by meticulous dissection, parathyroid autotransplantation (PTHAT) has been performed increasingly to avoid permanent hypoparathyroidism. METHODS: From January 1995 to October 1997, PTHAT was performed routinely for devascularized or inadvertently removed glands in 98 (36%) of 271 patients undergoing thyroidectomy. Potential risk factors and the impact of PTHAT on postoperative hypocalcemia were studied...
December 1998: Surgery
B M Meiser, W von Scheidt, M Weis, D Böhm, F Kur, J Koglin, H Reichenspurner, P Uberfuhr, B Reichart
In spite of pharmacological progress, end stage congestive heart failure is still associated with a decrease in quality and expectation of life. Heart transplantation remains the last therapeutic option for these patients. While the one year survival rate has increased over the last few years up to 84%, a major problem remains the significant lack of donors. Therefore, the criteria for the selection of candidates for cardiac transplantation have to be kept quite tight: Evidence of poor outcome without transplantation is associated with ejection fractions below 20 to 25%, cardiac indices less than 2...
October 1997: Herz
M T Zanella, M Baptista, C H Costa, N E Kohlmann, O Kohlmann Júnior, A B Ribeiro
PURPOSE: To compare the effects of chlortalidone (CL) and captopril (Cp) upon glucose tolerance and serum insulin levels in essential hypertensive patients. METHODS: Non obese essential hypertensive patients with normal glucose tolerance test (OGTT) and diastolic blood pressure (DBP) > 90 mmHg and < or = 115 mmHg in the seated position were treated, in a randomized fashion, with Cp or CL during 16 weeks, after 16 weeks of placebo. The OGTT was performed after placebo and after active therapy, with serum insulin levels determinations carried out before and 120 minutes after oral glucose load...
July 1996: Arquivos Brasileiros de Cardiologia
I Nakao, T Ito, N Kasai
In outlining the pathology of various electrolyte metabolism abnormalities in cancer patients we considered the main clinical points between pathologies and emergency treatment. In regard to sodium (Na+) metabolism, one pathologic state that requires our attention is hypernatremia. Hypernatremia is accompanied with dehydration and is due to water loss, vomiting, diarrhea and renal insufficiency. One of the major causes of this condition is lack of the antidiuretic hormone due to intracranial metastasis of the tumor...
February 1983: Gan to Kagaku Ryoho. Cancer & Chemotherapy
R Kujat, R Pichlmayr
Irrigants for whole gut irrigation nearly exclusively influence the fluid-, electrolyte- and acid-base-balance. Mannitol and sodium sulphate solutions have badly been tolerated and left a bowel full of gas and fluid. Mannitol showed only small changes in serum electrolytes. Sodium sulphate led to a marked hypocalemia. Mannitol plus electrolytes led to a gas-filled bowel. Ringer's lactate showed only small changes in serum electrolytes and a good compatibility. None of the investigated solutions were better than modified Hewitt's solution, so that we are doing our whole gut irrigations with this solution...
October 1983: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"